| Thursday, February 27 |
| Future Twin Willie Banks is born in Jersey City, NJ. |
| Tuesday, March 25 |
| Future Twin Erik Schullstrom is born in San Diego, CA. |
| Monday, April 7 |
| » Major-league debuts: Bob Didier (Braves) |
| Tuesday, April 8 |
| » Lost to Royals (1-0), 4-3 | Municipal Stadium (0-1) | 0-1 | |
| » W: Moe Drabowsky (1-0) L: Joe Grzenda (0-1) | Second | 1 out |
| » Major-league debuts: Charlie Manuel and Dick Woodson (Twins) |
| Wednesday, April 9 |
| » Lost to Royals (2-0), 4-3 | Municipal Stadium (0-2) | 0-2 | Lost 2 |
| » W: Tom Burgmeier (1-0) L: Bob Miller (0-1) | Third | 2 out |
| » Major-league debuts: Bill Butler (Royals) |
| Friday, April 11 |
| » Lost to Angels (2-1), 5-3 | Anaheim Stadium (0-1) | 0-3 | Lost 3 |
| » W: George Brunet (1-0) L: Jim Perry (0-1) S: Hoyt Wilhelm (2) | Third | 2 out |
| Saturday, April 12 |
| » Lost to Angels (3-1), 4-3 | Anaheim Stadium (0-2) | 0-4 | Lost 4 |
| » W: Rudy May (1-0) L: Dave Boswell (0-1) S: Hoyt Wilhelm (3) | Fourth | 3 out |
| Sunday, April 13 |
| » Defeated Angels (3-2), 5-4 | Anaheim Stadium (1-2) | 1-4 | |
| » W: Ron Perranoski (1-0) L: Pedro Borbon (1-1) S: Bob Miller (1) | Fifth | 2½ out |
| Tuesday, April 15 |
| » Defeated Athletics (3-4), 5-4 | Oakland-Alameda County Stadium (1-0) | 2-4 | Won 2 |
| » W: Jim Kaat (1-0) L: Catfish Hunter (1-1) S: Ron Perranoski (1) | Fourth | 2½ out |
| Wednesday, April 16 |
| » Defeated Pilots (3-4), 6-4 | Sick's Stadium (1-0) | 3-4 | Won 3 |
| » W: Ron Perranoski (2-0) L: Jack Aker (0-1) | Fourth | 1½ out |
| Friday, April 18 |
| » Defeated Angels (3-5), 6-0 | Metropolitan Stadium (1-0) | 4-4 | Won 4 |
| » W: Tom Hall (1-0) L: Rudy May (1-1) | Third | 1 out |
| Saturday, April 19 |
| » Defeated Angels (3-6), 6-5 | Metropolitan Stadium (2-0) | 5-4 | Won 5 |
| » W: Ron Perranoski (3-0) L: Eddie Fisher (0-1) | First | -- |
| Sunday, April 20 |
| » Defeated Angels (3-7), 12-1 | Metropolitan Stadium (3-0) | 6-4 | Won 6 |
| » W: Dave Boswell (1-1) L: Andy Messersmith (0-1) | First | -- |
| Monday, April 21 |
| » Defeated Athletics (6-6), 8-4 | Metropolitan Stadium (4-0) | 7-4 | Won 7 |
| » W: Dean Chance (1-0) L: Chuck Dobson (1-2) S: Bob Miller (2) | First | -- |
| Tuesday, April 22 |
| » Lost to Athletics (7-6), 7-0 | Metropolitan Stadium (4-1) | 7-5 | |
| » W: Rollie Fingers (1-0) L: Tom Hall (1-1) | First | -- |
| Wednesday, April 23 |
| » Defeated Athletics (7-7), 7-6 | Metropolitan Stadium (5-1) | 8-5 | |
| » W: Jim Perry (1-1) L: Catfish Hunter (1-2) S: Ron Perranoski (2) | First | -- |
| Thursday, April 24 |
| » Lost to Athletics (8-7), 6-4 | Metropolitan Stadium (5-2) | 8-6 | |
| » W: Blue Moon Odom (3-1) L: Dave Boswell (1-2) S: Lew Krausse (2) | Second | 1 out |
| Friday, April 25 |
| » Lost to White Sox (8-5), 6-5 | Comiskey Park I (0-1) | 8-7 | Lost 2 |
| » W: Bob Locker (1-0) L: Ron Perranoski (3-1) | Third | 1 out |
| Saturday, April 26 |
| » Defeated White Sox (8-6), 12-1 | Comiskey Park I (1-1) | 9-7 | |
| » W: Dean Chance (2-0) L: Joe Horlen (2-2) S: Joe Grzenda (1) | Second | 1 out |
| Sunday, April 27 |
| » Defeated White Sox (8-7), 4-3 | Comiskey Park I (2-1) | 10-7 | Won 2 |
| » W: Dave Boswell (2-2) L: Gary Peters (1-3) | First | -- |
| Monday, April 28 |
| » Defeated Royals (8-9), 4-0 | Metropolitan Stadium (6-2) | 11-7 | Won 3 |
| » W: Jim Perry (2-1) L: Mike Hedlund (1-1) | First | -- |
| Tuesday, April 29 |
| » Defeated Royals (8-10), 9-1 | Metropolitan Stadium (7-2) | 12-7 | Won 4 |
| » W: Dick Woodson (1-0) L: Roger Nelson (1-2) | First | -- |
| Wednesday, April 30 |
| » Defeated Pilots (7-11), 6-4 | Metropolitan Stadium (8-2) | 13-7 | Won 5 |
| » W: Tom Hall (2-1) L: Gene Brabender (0-2) S: Ron Perranoski (3) | First | -- |
| Thursday, May 1 |
| » Defeated Pilots (7-12), 4-1 | Metropolitan Stadium (9-2) | 14-7 | Won 6 |
| » W: Dave Boswell (3-2) L: Gary Bell (1-2) S: Joe Grzenda (2) | First | -- |
| Saturday, May 3 |
| » Defeated White Sox (8-10), 3-1 | Metropolitan Stadium (10-2) | 15-7 | Won 7 |
| » W: Jim Perry (3-1) L: Gary Peters (1-4) S: Ron Perranoski (4) | First | -- |
| Sunday, May 4 |
| » Defeated White Sox (8-11), 4-3 | Metropolitan Stadium (11-2) | 16-7 | Won 8 |
| » W: Joe Grzenda (1-1) L: Bob Locker (1-1) S: Ron Perranoski (5) | First | -- |
| Tuesday, May 6 |
| » Lost to Indians (4-18), 1-0 | Cleveland Stadium (0-1) | 16-8 | |
| » W: Sam McDowell (2-3) L: Dave Boswell (3-3) | First | -- |
| Wednesday, May 7 |
| » Defeated Indians (4-19), 10-3 | Cleveland Stadium (1-1) | 17-8 | |
| » W: Jim Kaat (2-0) L: Luis Tiant (0-6) | First | -- |
| Friday, May 9 |
| » Defeated Tigers (12-15), 6-2 | Tiger Stadium (1-0) | 18-8 | Won 2 |
| » W: Dean Chance (3-0) L: Earl Wilson (1-4) S: Ron Perranoski (6) | First | -- |
| Sunday, May 11 |
| » Lost to Tigers (13-15), 3-2 | Tiger Stadium (1-1) | 18-9 | |
| » W: Denny McLain (5-3) L: Jim Kaat (2-1) S: Pat Dobson (3) | First | -- |
| Tuesday, May 13 |
| » Defeated Orioles (22-12), 4-2 | Metropolitan Stadium (12-2) | 19-9 | |
| » W: Dave Boswell (4-3) L: Mike Cuellar (3-4) S: Ron Perranoski (7) | First | -- |
| Wednesday, May 14 |
| » Lost to Orioles (23-12), 9-8 | Metropolitan Stadium (12-3) | 19-10 | |
| » W: Tom Phoebus (4-0) L: Dick Woodson (1-1) S: Eddie Watt (3) | First | -- |
| Thursday, May 15 |
| » Lost to Orioles (24-12), 5-0 | Metropolitan Stadium (12-4) | 19-11 | Lost 2 |
| » W: Dave McNally (6-0) L: Jim Kaat (2-2) | Second | ½ out |
| Saturday, May 17 |
| » Lost to Tigers (16-16), 6-0 | Metropolitan Stadium (12-5) | 19-12 | Lost 3 |
| » W: Denny McLain (6-3) L: Dean Chance (3-1) | Second | 1 out |
| Sunday, May 18 |
| » Lost to Tigers (17-16), 8-2 | Metropolitan Stadium (12-6) | 19-13 | Lost 4 |
| » W: Mickey Lolich (5-1) L: Dave Boswell (4-4) | Second | 1½ out |
| Tuesday, May 20 |
| » Defeated Orioles (27-13), 3-2 | Memorial Stadium (1-0) | 20-13 | |
| » W: Jim Kaat (3-2) L: Marcelino Lopez (0-1) S: Ron Perranoski (8) | Second | ½ out |
| Wednesday, May 21 |
| » Lost to Orioles (28-13), 4-3 | Memorial Stadium (1-1) | 20-14 | |
| » W: Tom Phoebus (5-0) L: Dave Boswell (4-5) S: Pete Richert (4) | Second | ½ out |
| » Major-league debuts: Jerry Crider (Twins) |
| Thursday, May 22 |
| » Lost to Orioles (29-13), 6-2 | Memorial Stadium (1-2) | 20-15 | Lost 2 |
| » W: Dick Hall (3-1) L: Ron Perranoski (3-2) S: Eddie Watt (4) | Second | 1 out |
| Friday, May 23 |
| » Lost to Yankees (20-21), 3-1 | Yankee Stadium (0-1) | 20-16 | Lost 3 |
| » W: Mel Stottlemyre (7-3) L: Tom Hall (2-2) | Second | 1 out |
| Saturday, May 24 |
| » Defeated Yankees (20-22), 2-1 | Yankee Stadium (1-1) | 21-16 | |
| » W: Jim Kaat (4-2) L: Bill Burbach (2-4) | First | -- |
| Sunday, May 25 |
| » Defeated Yankees (20-23), 2-1 | Yankee Stadium (2-1) | 22-16 | Won 2 |
| » W: Dave Boswell (5-5) L: Fritz Peterson (6-5) | First | -- |
| » Defeated Yankees (20-24), 3-2 | Yankee Stadium (3-1) | 23-16 | Won 3 |
| » W: Dick Woodson (2-1) L: Stan Bahnsen (1-7) S: Ron Perranoski (9) | First | -- |
| Monday, May 26 |
| » Defeated Senators (20-26), 7-1 | Robert F. Kennedy Stadium (1-0) | 24-16 | Won 4 |
| » W: Jim Perry (4-1) L: Joe Coleman (2-5) | First | -- |
| Tuesday, May 27 |
| » Lost to Senators (21-26), 5-1 | Robert F. Kennedy Stadium (1-1) | 24-17 | |
| » W: Barry Moore (3-1) L: Tom Hall (2-3) | First | -- |
| Wednesday, May 28 |
| » Lost to Senators (22-26), 4-3 | Robert F. Kennedy Stadium (1-2) | 24-18 | Lost 2 |
| » W: Dennis Higgins (4-5) L: Jim Kaat (4-3) | First | -- |
| Friday, May 30 |
| » Lost to Red Sox (29-15), 3-2 | Fenway Park (0-1) | 24-19 | Lost 3 |
| » W: Jim Lonborg (4-0) L: Dave Boswell (5-6) S: Vicente Romo (9) | First | -- |
| Saturday, May 31 |
| » Defeated Red Sox (29-16), 10-4 | Fenway Park (1-1) | 25-19 | |
| » W: Dick Woodson (3-1) L: Sonny Siebert (4-5) S: Ron Perranoski (10) | First | -- |
| Sunday, June 1 |
| » Lost to Red Sox (30-16), 5-2 | Fenway Park (1-2) | 25-20 | |
| » W: Ray Culp (9-2) L: Jim Perry (4-2) S: Sparky Lyle (5) | First | -- |
| Monday, June 2 |
| » Defeated Yankees (24-26), 3-2 | Metropolitan Stadium (13-6) | 26-20 | |
| » W: Jim Kaat (5-3) L: Stan Bahnsen (1-8) | First | -- |
| Tuesday, June 3 |
| » Defeated Yankees (24-27), 4-0 | Metropolitan Stadium (14-6) | 27-20 | Won 2 |
| » W: Dave Boswell (6-6) L: Fritz Peterson (7-6) S: Ron Perranoski (11) | First | -- |
| Wednesday, June 4 |
| » Defeated Yankees (24-28), 4-2 | Metropolitan Stadium (15-6) | 28-20 | Won 3 |
| » W: Tom Hall (3-3) L: Mel Stottlemyre (8-4) S: Ron Perranoski (12) | First | -- |
| Friday, June 6 |
| » Lost to Senators (28-28), 1-0 | Metropolitan Stadium (15-7) | 28-21 | |
| » W: Barry Moore (5-1) L: Jim Kaat (5-4) S: Darold Knowles (1) | First | -- |
| Saturday, June 7 |
| » Defeated Senators (28-29), 10-1 | Metropolitan Stadium (16-7) | 29-21 | |
| » W: Dave Boswell (7-6) L: Jim Hannan (2-5) S: Bob Miller (3) | First | -- |
| Sunday, June 8 |
| » Lost to Senators (29-29), 7-5 | Metropolitan Stadium (16-8) | 29-22 | |
| » W: Casey Cox (4-1) L: Tom Hall (3-4) | First | -- |
| Monday, June 9 |
| » Lost to Red Sox (35-18), 5-3 | Metropolitan Stadium (16-9) | 29-23 | Lost 2 |
| » W: Ray Jarvis (3-1) L: Dick Woodson (3-2) S: Vicente Romo (10) | First | -- |
| Tuesday, June 10 |
| » Defeated Red Sox (35-19), 6-2 | Metropolitan Stadium (17-9) | 30-23 | |
| » W: Jim Kaat (6-4) L: Ray Culp (9-3) | First | -- |
| Wednesday, June 11 |
| » Lost to Red Sox (36-19), 13-5 | Metropolitan Stadium (17-10) | 30-24 | |
| » W: Sonny Siebert (5-6) L: Dave Boswell (7-7) | First | -- |
| Friday, June 13 |
| » Lost to Indians (19-34), 6-4 | Metropolitan Stadium (17-11) | 30-25 | Lost 2 |
| » W: Sam McDowell (7-6) L: Jim Perry (4-3) | First | -- |
| Saturday, June 14 |
| » Lost to Indians (20-34), 12-0 | Metropolitan Stadium (17-12) | 30-26 | Lost 3 |
| » W: Dick Ellsworth (3-2) L: Jim Kaat (6-5) | Second | 1 out |
| Sunday, June 15 |
| » Defeated Indians (20-35), 3-2 | Metropolitan Stadium (18-12) | 31-26 | |
| » W: Dave Boswell (8-7) L: Steve Hargan (1-3) | Second | 1 out |
| Monday, June 16 |
| » Defeated Angels (19-37), 8-2 | Metropolitan Stadium (19-12) | 32-26 | Won 2 |
| » W: Jim Perry (5-3) L: Tom Murphy (4-4) | First | -- |
| Tuesday, June 17 |
| » Lost to Angels (20-37), 13-1 | Metropolitan Stadium (19-13) | 32-27 | |
| » W: Andy Messersmith (2-5) L: Danny Morris (0-1) | Second | 1 out |
| Wednesday, June 18 |
| » Defeated Angels (20-38), 3-1 | Metropolitan Stadium (20-13) | 33-27 | |
| » W: Jim Kaat (7-5) L: Hoyt Wilhelm (2-6) | Second | ½ out |
| Thursday, June 19 |
| » Defeated Angels (20-39), 8-1 | Metropolitan Stadium (21-13) | 34-27 | Won 2 |
| » W: Dick Woodson (4-2) L: George Brunet (2-6) | Second | 1 out |
| Friday, June 20 |
| » Lost to Athletics (34-26), 3-2 | Oakland-Alameda County Stadium (1-1) | 34-28 | |
| » W: Marcel Lachemann (2-0) L: Bob Miller (0-2) | Second | 1 out |
| Saturday, June 21 |
| » Defeated Athletics (34-27), 14-4 | Oakland-Alameda County Stadium (2-1) | 35-28 | |
| » W: Joe Grzenda (2-1) L: Paul Lindblad (4-1) | Second | 1 out |
| Sunday, June 22 |
| » Lost to Athletics (35-27), 7-3 | Oakland-Alameda County Stadium (2-2) | 35-29 | |
| » W: Chuck Dobson (8-5) L: Jim Kaat (7-6) | Second | 1 out |
| » Defeated Athletics (35-28), 4-3 | Oakland-Alameda County Stadium (3-2) | 36-29 | |
| » W: Jim Perry (6-3) L: Rollie Fingers (3-4) S: Jim Kaat (1) | Second | 1 out |
| Monday, June 23 |
| » Lost to Angels (23-41), 5-2 | Anaheim Stadium (1-3) | 36-30 | |
| » W: George Brunet (3-6) L: Dick Woodson (4-3) S: Ken Tatum (2) | Second | 1½ out |
| Tuesday, June 24 |
| » Defeated Angels (23-42), 5-3 | Anaheim Stadium (2-3) | 37-30 | |
| » W: Dave Boswell (9-7) L: Tom Murphy (4-5) | First | -- |
| Wednesday, June 25 |
| » Defeated Angels (23-43), 3-2 | Anaheim Stadium (3-3) | 38-30 | Won 2 |
| » W: Ron Perranoski (4-2) L: Andy Messersmith (3-6) | First | -- |
| Thursday, June 26 |
| » Defeated Angels (23-44), 7-4 | Anaheim Stadium (4-3) | 39-30 | Won 3 |
| » W: Al Worthington (1-0) L: Jim McGlothlin (5-7) | First | -- |
| Friday, June 27 |
| » Lost to Royals (28-42), 9-8 | Municipal Stadium (0-3) | 39-31 | |
| » W: Moe Drabowsky (5-5) L: Ron Perranoski (4-3) | Second | 1½ out |
| Saturday, June 28 |
| » Lost to Royals (29-42), 7-4 | Municipal Stadium (0-4) | 39-32 | Lost 2 |
| » W: Galen Cisco (1-0) L: Dave Boswell (9-8) S: Moe Drabowsky (7) | Second | 1½ out |
| Sunday, June 29 |
| » Lost to Royals (30-42), 7-2 | Municipal Stadium (0-5) | 39-33 | Lost 3 |
| » W: Wally Bunker (4-4) L: Jim Perry (6-4) | Second | 1½ out |
| » Defeated Royals (30-43), 12-2 | Municipal Stadium (1-5) | 40-33 | |
| » W: Jim Kaat (8-6) L: Jim Rooker (0-5) | Second | 1½ out |
| Monday, June 30 |
| » Defeated White Sox (31-41), 7-3 | Comiskey Park I (3-1) | 41-33 | Won 2 |
| » W: Bob Miller (1-2) L: Joe Horlen (4-9) S: Ron Perranoski (13) | Second | 2 out |
| Tuesday, July 1 |
| » Defeated White Sox (31-42), 10-5 | Comiskey Park I (4-1) | 42-33 | Won 3 |
| » W: Dick Woodson (5-3) L: Wilbur Wood (5-4) | Second | 2 out |
| Wednesday, July 2 |
| » Defeated White Sox (31-43), 4-2 | County Stadium (1-0) | 43-33 | Won 4 |
| » W: Dave Boswell (10-8) L: Tommy John (5-6) S: Ron Perranoski (14) | Second | 2 out |
| Thursday, July 3 |
| » Lost to White Sox (32-43), 5-4 | Comiskey Park I (4-2) | 43-34 | |
| » W: Dan Osinski (3-2) L: Ron Perranoski (4-4) | Second | 2 out |
| Friday, July 4 |
| » Defeated Athletics (42-32), 10-4 | Metropolitan Stadium (22-13) | 44-34 | |
| » W: Bob Miller (2-2) L: Catfish Hunter (5-7) | Second | 2 out |
| Saturday, July 5 |
| » Defeated Athletics (42-33), 13-1 | Metropolitan Stadium (23-13) | 45-34 | Won 2 |
| » W: Jim Perry (7-4) L: Chuck Dobson (9-7) | First | -- |
| Sunday, July 6 |
| » Defeated Athletics (42-34), 7-6 | Metropolitan Stadium (24-13) | 46-34 | Won 3 |
| » W: Joe Grzenda (3-1) L: Rollie Fingers (3-5) S: Ron Perranoski (15) | First | -- |
| Monday, July 7 |
| » Defeated Royals (35-47), 6-5 | Metropolitan Stadium (25-13) | 47-34 | Won 4 |
| » W: Dick Woodson (6-3) L: Jim Rooker (0-6) | First | -- |
| Tuesday, July 8 |
| » Defeated Royals (35-48), 4-3 | Metropolitan Stadium (26-13) | 48-34 | Won 5 |
| » W: Al Worthington (2-0) L: Moe Drabowsky (6-6) S: Ron Perranoski (16) | First | -- |
| Wednesday, July 9 |
| » Lost to Royals (36-48), 4-3 | Metropolitan Stadium (26-14) | 48-35 | |
| » W: Roger Nelson (6-7) L: Dick Woodson (6-4) | First | -- |
| Thursday, July 10 |
| » Defeated Royals (36-49), 6-5 | Metropolitan Stadium (27-14) | 49-35 | |
| » W: Dave Boswell (11-8) L: Dick Drago (4-8) S: Ron Perranoski (17) | First | -- |
| Future Twin Marty Cordova is born in Las Vegas, NV. |
| Friday, July 11 |
| » Defeated Pilots (38-47), 9-3 | Metropolitan Stadium (28-14) | 50-35 | Won 2 |
| » W: Tom Hall (4-4) L: Gene Brabender (7-6) | First | -- |
| » Major-league debuts: Dick Baney (Pilots) |
| Saturday, July 12 |
| » Defeated Pilots (38-48), 11-1 | Metropolitan Stadium (29-14) | 51-35 | Won 3 |
| » W: Jim Perry (8-4) L: Marty Pattin (7-8) | First | -- |
| Sunday, July 13 |
| » Defeated Pilots (38-49), 5-2 | Metropolitan Stadium (30-14) | 52-35 | Won 4 |
| » W: Jim Kaat (9-6) L: Garry Roggenburk (2-3) | First | -- |
| » Defeated Pilots (38-50), 5-4 | Metropolitan Stadium (31-14) | 53-35 | Won 5 |
| » W: Ron Perranoski (5-4) L: Diego Segui (6-4) | First | -- |
| Monday, July 14 |
| » Defeated White Sox (38-51), 4-3 | Metropolitan Stadium (32-14) | 54-35 | Won 6 |
| » W: Al Worthington (3-0) L: Wilbur Wood (6-6) | First | -- |
| Wednesday, July 16 |
| » Defeated White Sox (38-52), 9-8 | Metropolitan Stadium (33-14) | 55-35 | Won 7 |
| » W: Al Worthington (4-0) L: Don Secrist (0-1) | First | -- |
| » Defeated White Sox (38-53), 6-3 | Metropolitan Stadium (34-14) | 56-35 | Won 8 |
| » W: Jim Perry (9-4) L: Gary Peters (6-10) S: Ron Perranoski (18) | First | -- |
| Thursday, July 17 |
| » Defeated White Sox (38-54), 8-5 | Metropolitan Stadium (35-14) | 57-35 | Won 9 |
| » W: Jim Kaat (10-6) L: Joe Horlen (6-11) S: Jerry Crider (1) | First | -- |
| Friday, July 18 |
| » Lost to Pilots (39-53), 2-1 | Sick's Stadium (1-1) | 57-36 | |
| » W: Diego Segui (7-4) L: Ron Perranoski (5-5) | First | -- |
| » Lost to Pilots (40-53), 3-2 | Sick's Stadium (1-2) | 57-37 | Lost 2 |
| » W: Fred Talbot (5-3) L: Dave Boswell (11-9) S: John O'Donoghue (4) | First | -- |
| Saturday, July 19 |
| » Defeated Pilots (40-54), 11-7 | Sick's Stadium (2-2) | 58-37 | |
| » W: Jim Perry (10-4) L: John Gelnar (2-6) | First | -- |
| Former Twin Al Williams dies in Groves, TX at the age of 56. |
| Sunday, July 20 |
| » Defeated Pilots (40-55), 4-0 | Sick's Stadium (3-2) | 59-37 | Won 2 |
| » W: Jim Perry (11-4) L: John Gelnar (2-7) | First | -- |
| Thursday, July 24 |
| » Lost to Indians (39-59), 6-5 | Cleveland Stadium (1-2) | 59-38 | |
| » W: Ron Law (1-0) L: Bob Miller (2-3) | First | -- |
| Friday, July 25 |
| » Defeated Indians (39-60), 4-2 | Cleveland Stadium (2-2) | 60-38 | |
| » W: Ron Perranoski (6-5) L: Mike Paul (2-8) | First | -- |
| Saturday, July 26 |
| » Lost to Indians (40-60), 6-3 | Cleveland Stadium (2-3) | 60-39 | |
| » W: Dick Ellsworth (6-5) L: Bob Miller (2-4) S: Stan Williams (7) | First | -- |
| Future Twin Greg Colbrunn is born in Fontana, CA. |
| Sunday, July 27 |
| » Defeated Indians (40-61), 8-7 | Cleveland Stadium (3-3) | 61-39 | |
| » W: Jerry Crider (1-0) L: Ron Law (1-1) S: Ron Perranoski (19) | First | -- |
| » Major-league debuts: Frank Baker (Indians) |
| Tuesday, July 29 |
| » Defeated Tigers (55-43), 5-2 | Metropolitan Stadium (36-14) | 62-39 | Won 2 |
| » W: Jim Perry (12-4) L: Mickey Lolich (14-3) S: Al Worthington (1) | First | -- |
| » Defeated Tigers (55-44), 11-5 | Metropolitan Stadium (37-14) | 63-39 | Won 3 |
| » W: Bob Miller (3-4) L: Denny McLain (15-6) S: Ron Perranoski (20) | First | -- |
| Wednesday, July 30 |
| » Lost to Tigers (56-44), 3-1 | Metropolitan Stadium (37-15) | 63-40 | |
| » W: Earl Wilson (10-7) L: Jim Kaat (10-7) S: Don McMahon (10) | First | -- |
| Thursday, July 31 |
| » Defeated Tigers (56-45), 5-3 | Metropolitan Stadium (38-15) | 64-40 | |
| » W: Dave Boswell (12-9) L: Mike Kilkenny (1-1) | First | -- |
| Friday, August 1 |
| » Defeated Orioles (72-32), 4-3 | Metropolitan Stadium (39-15) | 65-40 | Won 2 |
| » W: Ron Perranoski (7-5) L: Dave Leonhard (6-4) | First | -- |
| Future Twin Kevin Jarvis is born in Lexington, KY. |
| Saturday, August 2 |
| » Lost to Orioles (73-32), 6-5 | Metropolitan Stadium (39-16) | 65-41 | |
| » W: Mike Cuellar (13-9) L: Al Worthington (4-1) S: Pete Richert (8) | First | -- |
| Sunday, August 3 |
| » Defeated Orioles (73-33), 5-2 | Metropolitan Stadium (40-16) | 66-41 | |
| » W: Jim Kaat (11-7) L: Dave McNally (15-1) S: Al Worthington (2) | First | -- |
| Monday, August 4 |
| » Defeated Tigers (58-47), 7-1 | Tiger Stadium (2-1) | 67-41 | Won 2 |
| » W: Bob Miller (4-4) L: Mike Kilkenny (1-2) S: Ron Perranoski (21) | First | -- |
| Tuesday, August 5 |
| » Lost to Tigers (59-47), 4-3 | Tiger Stadium (2-2) | 67-42 | |
| » W: John Hiller (3-3) L: Dick Woodson (6-5) | First | -- |
| Wednesday, August 6 |
| » Defeated Tigers (59-48), 3-1 | Tiger Stadium (3-2) | 68-42 | |
| » W: Jim Perry (13-4) L: Mickey Lolich (14-5) | First | -- |
| Thursday, August 7 |
| » Lost to Tigers (60-48), 6-4 | Tiger Stadium (3-3) | 68-43 | |
| » W: Tom Timmermann (1-1) L: Jim Kaat (11-8) S: Don McMahon (11) | First | -- |
| Friday, August 8 |
| » Lost to Orioles (77-34), 6-5 | Memorial Stadium (1-3) | 68-44 | Lost 2 |
| » W: Marcelino Lopez (4-2) L: Ron Perranoski (7-6) | First | -- |
| Saturday, August 9 |
| » Lost to Orioles (78-34), 5-1 | Memorial Stadium (1-4) | 68-45 | Lost 3 |
| » W: Jim Palmer (10-2) L: Dean Chance (3-2) S: Pete Richert (10) | First | -- |
| Sunday, August 10 |
| » Lost to Orioles (79-34), 2-0 | Memorial Stadium (1-5) | 68-46 | Lost 4 |
| » W: Mike Cuellar (15-9) L: Jim Perry (13-5) | First | -- |
| Tuesday, August 12 |
| » Lost to Yankees (58-57), 10-3 | Yankee Stadium (3-2) | 68-47 | Lost 5 |
| » W: Steve Hamilton (3-3) L: Jim Kaat (11-9) S: Lindy McDaniel (3) | First | -- |
| » Major-league debuts: Bill Zepp (Twins) |
| Wednesday, August 13 |
| » Defeated Yankees (58-58), 5-2 | Yankee Stadium (4-2) | 69-47 | |
| » W: Tom Hall (5-4) L: Mel Stottlemyre (16-9) | First | -- |
| Friday, August 15 |
| » Defeated Senators (60-60), 2-0 | Robert F. Kennedy Stadium (2-2) | 70-47 | Won 2 |
| » W: Jim Perry (14-5) L: Jim Shellenback (4-7) S: Ron Perranoski (22) | First | -- |
| Saturday, August 16 |
| » Lost to Senators (61-60), 6-5 | Robert F. Kennedy Stadium (2-3) | 70-48 | |
| » W: Darold Knowles (6-2) L: Jim Kaat (11-10) | First | -- |
| Sunday, August 17 |
| » Defeated Senators (61-61), 4-3 | Robert F. Kennedy Stadium (3-3) | 71-48 | |
| » W: Ron Perranoski (8-6) L: Dennis Higgins (9-9) | First | -- |
| Monday, August 18 |
| » Lost to Red Sox (64-56), 7-6 | Fenway Park (1-3) | 71-49 | |
| » W: Sparky Lyle (6-1) L: Ron Perranoski (8-7) | First | -- |
| Tuesday, August 19 |
| » Defeated Red Sox (64-57), 8-6 | Fenway Park (2-3) | 72-49 | |
| » W: Dean Chance (4-2) L: Sparky Lyle (6-2) | First | -- |
| Wednesday, August 20 |
| » Lost to Red Sox (65-57), 7-6 | Fenway Park (2-4) | 72-50 | |
| » W: Sparky Lyle (7-2) L: Ron Perranoski (8-8) | First | -- |
| Friday, August 22 |
| » Defeated Yankees (62-62), 6-0 | Metropolitan Stadium (41-16) | 73-50 | |
| » W: Dave Boswell (13-9) L: Stan Bahnsen (7-12) S: Ron Perranoski (23) | First | -- |
| Saturday, August 23 |
| » Defeated Yankees (62-63), 8-3 | Metropolitan Stadium (42-16) | 74-50 | Won 2 |
| » W: Jim Perry (15-5) L: Mel Stottlemyre (16-11) | First | -- |
| Sunday, August 24 |
| » Defeated Yankees (62-64), 1-0 | Metropolitan Stadium (43-16) | 75-50 | Won 3 |
| » W: Tom Hall (6-4) L: Al Downing (4-4) | First | -- |
| Monday, August 25 |
| » Lost to Senators (66-62), 7-3 | Metropolitan Stadium (43-17) | 75-51 | |
| » W: Dick Bosman (10-5) L: Jim Kaat (11-11) S: Darold Knowles (10) | First | -- |
| Tuesday, August 26 |
| » Defeated Senators (66-63), 6-4 | Metropolitan Stadium (44-17) | 76-51 | |
| » W: Dave Boswell (14-9) L: Barry Moore (8-6) S: Ron Perranoski (24) | First | -- |
| Wednesday, August 27 |
| » Defeated Senators (66-64), 4-2 | Metropolitan Stadium (45-17) | 77-51 | Won 2 |
| » W: Jim Perry (16-5) L: Joe Coleman (9-11) | First | -- |
| Friday, August 29 |
| » Defeated Red Sox (69-60), 10-4 | Metropolitan Stadium (46-17) | 78-51 | Won 3 |
| » W: Tom Hall (7-4) L: Jim Lonborg (7-8) | First | -- |
| Saturday, August 30 |
| » Lost to Red Sox (70-60), 7-5 | Metropolitan Stadium (46-18) | 78-52 | |
| » W: Mike Nagy (10-2) L: Dave Boswell (14-10) S: Sparky Lyle (13) | First | -- |
| Sunday, August 31 |
| » Defeated Red Sox (70-61), 6-2 | Metropolitan Stadium (47-18) | 79-52 | |
| » W: Jim Perry (17-5) L: Vicente Romo (5-10) S: Ron Perranoski (25) | First | -- |
| Monday, September 1 |
| » Defeated Indians (54-80), 7-5 | Metropolitan Stadium (48-18) | 80-52 | Won 2 |
| » W: Dean Chance (5-2) L: Sam McDowell (15-12) S: Ron Perranoski (26) | First | -- |
| Tuesday, September 2 |
| » Defeated Indians (54-81), 5-2 | Metropolitan Stadium (49-18) | 81-52 | Won 3 |
| » W: Tom Hall (8-4) L: Luis Tiant (8-18) S: Dick Woodson (1) | First | -- |
| » Major-league debuts: Phil Hennigan (Indians) |
| Wednesday, September 3 |
| » Defeated Indians (54-82), 7-1 | Metropolitan Stadium (50-18) | 82-52 | Won 4 |
| » W: Dave Boswell (15-10) L: Steve Hargan (5-12) | First | -- |
| Thursday, September 4 |
| » Defeated Athletics (75-59), 10-5 | Oakland-Alameda County Stadium (4-2) | 83-52 | Won 5 |
| » W: Ron Perranoski (9-8) L: Ed Sprague (0-1) | First | -- |
| Friday, September 5 |
| » Lost to Athletics (76-59), 5-4 | Oakland-Alameda County Stadium (4-3) | 83-53 | |
| » W: Paul Lindblad (9-4) L: Ron Perranoski (9-9) S: Marcel Lachemann (2) | First | -- |
| Saturday, September 6 |
| » Defeated Athletics (76-60), 8-6 | Oakland-Alameda County Stadium (5-3) | 84-53 | |
| » W: Jim Kaat (12-11) L: George Lauzerique (3-4) S: Ron Perranoski (27) | First | -- |
| Sunday, September 7 |
| » Defeated Athletics (76-61), 16-4 | Oakland-Alameda County Stadium (6-3) | 85-53 | Won 2 |
| » W: Dave Boswell (16-10) L: Fred Talbot (5-9) S: Joe Grzenda (3) | First | -- |
| Monday, September 8 |
| » Lost to Angels (60-77), 6-4 | Anaheim Stadium (4-4) | 85-54 | |
| » W: Rudy May (8-11) L: Jim Perry (17-6) S: Ken Tatum (18) | First | -- |
| Tuesday, September 9 |
| » Defeated Angels (60-78), 11-7 | Anaheim Stadium (5-4) | 86-54 | |
| » W: Jim Kaat (13-11) L: Tom Bradley (0-1) | First | -- |
| » Major-league debuts: Tom Bradley and Marty Perez (Angels) |
| Wednesday, September 10 |
| » Lost to White Sox (55-84), 3-2 | Comiskey Park I (4-3) | 86-55 | |
| » W: Tommy John (7-11) L: Tom Hall (8-5) S: Wilbur Wood (12) | First | -- |
| Thursday, September 11 |
| » Lost to White Sox (56-84), 4-0 | Comiskey Park I (4-4) | 86-56 | Lost 2 |
| » W: Joe Horlen (11-15) L: Dave Boswell (16-11) | First | -- |
| Friday, September 12 |
| » Defeated Royals (59-84), 3-0 | Metropolitan Stadium (51-18) | 87-56 | |
| » W: Jim Perry (18-6) L: Jim Rooker (4-13) | First | -- |
| Saturday, September 13 |
| » Lost to Royals (60-84), 1-0 | Metropolitan Stadium (51-19) | 87-57 | |
| » W: Moe Drabowsky (9-9) L: Dean Chance (5-3) | First | -- |
| Sunday, September 14 |
| » Lost to Royals (61-84), 4-3 | Metropolitan Stadium (51-20) | 87-58 | Lost 2 |
| » W: Dick Drago (10-11) L: Ron Perranoski (9-10) | First | -- |
| Future Twin Mike Durant is born in Columbus, OH. |
| Monday, September 15 |
| » Defeated Athletics (79-67), 6-3 | Metropolitan Stadium (52-20) | 88-58 | |
| » W: Dave Boswell (17-11) L: Rollie Fingers (6-6) | First | -- |
| Tuesday, September 16 |
| » Defeated Athletics (79-68), 11-3 | Metropolitan Stadium (53-20) | 89-58 | Won 2 |
| » W: Jim Perry (19-6) L: Jim Nash (8-8) | First | -- |
| Wednesday, September 17 |
| » Lost to Angels (65-83), 6-4 | Metropolitan Stadium (53-21) | 89-59 | |
| » W: Tom Murphy (10-14) L: Dean Chance (5-4) S: Ken Tatum (21) | First | -- |
| Thursday, September 18 |
| » Lost to Angels (66-83), 5-2 | Metropolitan Stadium (53-22) | 89-60 | Lost 2 |
| » W: Andy Messersmith (16-9) L: Tom Hall (8-6) S: Vern Geishert (1) | First | -- |
| Friday, September 19 |
| » Defeated Pilots (58-92), 2-1 | Metropolitan Stadium (54-22) | 90-60 | |
| » W: Dave Boswell (18-11) L: Steve Barber (3-6) | First | -- |
| Saturday, September 20 |
| » Defeated Pilots (58-93), 3-2 | Metropolitan Stadium (55-22) | 91-60 | Won 2 |
| » W: Jim Perry (20-6) L: Diego Segui (11-6) | First | -- |
| Sunday, September 21 |
| » Lost to Pilots (59-93), 4-3 | Metropolitan Stadium (55-23) | 91-61 | |
| » W: John O'Donoghue (2-2) L: Jim Kaat (13-12) | First | -- |
| Monday, September 22 |
| » Defeated Royals (64-89), 4-3 | Municipal Stadium (2-5) | 92-61 | |
| » W: Bob Miller (5-4) L: J |
