| Friday, January 24 |
| Former Senator Tom Zachary dies in Burlington, NC at the age of 73. |
| Monday, April 7 |
| » Lost to Yankees (1-0), 8-4 | Robert F. Kennedy Stadium (0-1) | 0-1 | |
| » W: Mel Stottlemyre (1-0) L: Camilo Pascual (0-1) | Third | 1 out |
| Wednesday, April 9 |
| » Defeated Yankees (1-1), 6-4 | Robert F. Kennedy Stadium (1-1) | 1-1 | |
| » W: Joe Coleman (1-0) L: Stan Bahnsen (0-1) | Second | ½ out |
| Thursday, April 10 |
| » Defeated Yankees (1-2), 9-6 | Robert F. Kennedy Stadium (2-1) | 2-1 | Won 2 |
| » W: Jim Hannan (1-0) L: Fritz Peterson (0-1) S: Dennis Higgins (1) | Second | ½ out |
| Friday, April 11 |
| » Defeated Orioles (1-2), 4-0 | Memorial Stadium (1-0) | 3-1 | Won 3 |
| » W: Barry Moore (1-0) L: Jim Hardin (0-1) S: Dennis Higgins (2) | First | -- |
| Saturday, April 12 |
| » Lost to Orioles (2-2), 9-0 | Memorial Stadium (1-1) | 3-2 | |
| » W: Dave McNally (1-0) L: Camilo Pascual (0-2) | Second | ½ out |
| Sunday, April 13 |
| » Lost to Orioles (3-2), 2-0 | Memorial Stadium (1-2) | 3-3 | Lost 2 |
| » W: Jim Palmer (1-0) L: Joe Coleman (1-1) | Fifth | 2 out |
| » Lost to Orioles (4-2), 9-0 | Memorial Stadium (1-3) | 3-4 | Lost 3 |
| » W: Tom Phoebus (1-0) L: Dick Bosman (0-1) | Fifth | 2 out |
| Tuesday, April 15 |
| » Lost to Yankees (4-3), 8-2 | Yankee Stadium (0-1) | 3-5 | Lost 4 |
| » W: Fritz Peterson (1-1) L: Frank Bertaina (0-1) | Fifth | 2½ out |
| Thursday, April 17 |
| » Lost to Yankees (5-3), 7-3 | Yankee Stadium (0-2) | 3-6 | Lost 5 |
| » W: Mel Stottlemyre (3-0) L: Dennis Higgins (0-1) | Fourth | 3 out |
| » Defeated Yankees (5-4), 5-2 | Yankee Stadium (1-2) | 4-6 | |
| » W: Barry Moore (2-0) L: Stan Bahnsen (0-3) S: Dennis Higgins (3) | Fourth | 3 out |
| Friday, April 18 |
| » Lost to Orioles (8-3), 6-0 | Robert F. Kennedy Stadium (2-2) | 4-7 | |
| » W: Tom Phoebus (2-0) L: Joe Coleman (1-2) | Fifth | 4 out |
| Saturday, April 19 |
| » Defeated Orioles (8-4), 7-5 | Robert F. Kennedy Stadium (3-2) | 5-7 | |
| » W: Dick Bosman (1-1) L: Mike Cuellar (0-2) S: Dennis Higgins (4) | Fifth | 3 out |
| Former Senator Harry Cassady dies in Fresno, CA at the age of 89. |
| Sunday, April 20 |
| » Lost to Orioles (9-4), 2-1 | Robert F. Kennedy Stadium (3-3) | 5-8 | |
| » W: Dave McNally (2-0) L: Jim Hannan (1-1) S: Eddie Watt (2) | Fifth | 3 out |
| » Defeated Orioles (9-5), 5-2 | Robert F. Kennedy Stadium (4-3) | 6-8 | |
| » W: Frank Bertaina (1-1) L: Jim Hardin (0-2) S: Bob Humphreys (1) | Fifth | 3 out |
| Monday, April 21 |
| » Lost to Tigers (7-4), 2-0 | Robert F. Kennedy Stadium (4-4) | 6-9 | |
| » W: Joe Sparma (2-0) L: Barry Moore (2-1) | Fourth | 4 out |
| Tuesday, April 22 |
| » Lost to Tigers (8-4), 4-2 | Robert F. Kennedy Stadium (4-5) | 6-10 | Lost 2 |
| » W: John Hiller (1-0) L: Camilo Pascual (0-3) S: Don McMahon (3) | Fifth | 5 out |
| » Major-league debuts: Ron Woods (Tigers) |
| Wednesday, April 23 |
| » Defeated Red Sox (8-6), 9-3 | Fenway Park (1-0) | 7-10 | |
| » W: Joe Coleman (2-2) L: Sonny Siebert (0-2) S: Dennis Higgins (5) | Fifth | 5 out |
| Friday, April 25 |
| » Defeated Indians (1-13), 10-3 | Cleveland Stadium (1-0) | 8-10 | Won 2 |
| » W: Dick Bosman (2-1) L: Dick Ellsworth (0-1) | Fourth | 4½ out |
| Saturday, April 26 |
| » Defeated Indians (1-14), 8-1 | Cleveland Stadium (2-0) | 9-10 | Won 3 |
| » W: Casey Cox (1-0) L: Sam McDowell (0-3) | Fourth | 3½ out |
| Sunday, April 27 |
| » Defeated Indians (1-15), 6-5 | Cleveland Stadium (3-0) | 10-10 | Won 4 |
| » W: Dave Baldwin (1-0) L: Stan Williams (0-3) S: Dennis Higgins (6) | Fifth | 4 out |
| Monday, April 28 |
| » Defeated Tigers (9-9), 6-1 | Tiger Stadium (1-0) | 11-10 | Won 5 |
| » W: Camilo Pascual (1-3) L: Earl Wilson (1-3) S: Dick Bosman (1) | Fourth | 3½ out |
| Tuesday, April 29 |
| » Lost to Tigers (10-9), 5-4 | Tiger Stadium (1-1) | 11-11 | |
| » W: Dick Radatz (1-0) L: Frank Bertaina (1-2) | Fifth | 4 out |
| Wednesday, April 30 |
| » Defeated Red Sox (11-9), 1-0 | Robert F. Kennedy Stadium (5-5) | 12-11 | |
| » W: Jim Hannan (2-1) L: Lee Stange (1-3) S: Dennis Higgins (7) | Fourth | 4 out |
| Thursday, May 1 |
| » Defeated Red Sox (11-10), 7-6 | Robert F. Kennedy Stadium (6-5) | 13-11 | Won 2 |
| » W: Casey Cox (2-0) L: Ray Culp (4-1) S: Dave Baldwin (1) | Second | 3 out |
| Friday, May 2 |
| » Defeated Indians (3-16), 5-0 | Robert F. Kennedy Stadium (7-5) | 14-11 | Won 3 |
| » W: Dick Bosman (3-1) L: Luis Tiant (0-5) | Second | 3 out |
| » Major-league debuts: Jack Heidemann (Indians) |
| Saturday, May 3 |
| » Defeated Indians (3-17), 6-1 | Robert F. Kennedy Stadium (8-5) | 15-11 | Won 4 |
| » W: Camilo Pascual (2-3) L: Steve Hargan (0-2) S: Dave Baldwin (2) | Second | 3 out |
| Sunday, May 4 |
| » Defeated Indians (3-18), 4-3 | Robert F. Kennedy Stadium (9-5) | 16-11 | Won 5 |
| » W: Dennis Higgins (1-1) L: Jack Hamilton (0-2) | Second | 3½ out |
| Tuesday, May 6 |
| » Lost to Athletics (15-10), 4-1 | Oakland-Alameda County Stadium (0-1) | 16-12 | |
| » W: Catfish Hunter (2-2) L: Jim Hannan (2-2) | Third | 3½ out |
| Wednesday, May 7 |
| » Lost to Athletics (16-10), 5-4 | Oakland-Alameda County Stadium (0-2) | 16-13 | Lost 2 |
| » W: Rollie Fingers (3-1) L: Dennis Higgins (1-2) S: Paul Lindblad (2) | Third | 3½ out |
| Friday, May 9 |
| » Lost to Pilots (9-17), 2-0 | Sick's Stadium (0-1) | 16-14 | Lost 3 |
| » W: Mike Marshall (2-3) L: Joe Coleman (2-3) | Third | 3½ out |
| Saturday, May 10 |
| » Lost to Pilots (10-17), 16-13 | Sick's Stadium (0-2) | 16-15 | Lost 4 |
| » W: Diego Segui (2-2) L: Dennis Higgins (1-3) S: Gary Bell (1) | Third | 4½ out |
| Sunday, May 11 |
| » Lost to Pilots (11-17), 6-5 | Sick's Stadium (0-3) | 16-16 | Lost 5 |
| » W: Diego Segui (3-2) L: Dave Baldwin (1-1) | Third | 5½ out |
| Monday, May 12 |
| » Lost to Angels (10-17), 3-2 | Anaheim Stadium (0-1) | 16-17 | Lost 6 |
| » W: Tom Murphy (3-1) L: Dick Bosman (3-2) S: Hoyt Wilhelm (6) | Third | 6 out |
| Tuesday, May 13 |
| » Defeated Angels (10-18), 2-1 | Anaheim Stadium (1-1) | 17-17 | |
| » W: Dennis Higgins (2-3) L: Eddie Fisher (0-2) | Third | 5 out |
| Wednesday, May 14 |
| » Lost to Angels (11-18), 1-0 | Anaheim Stadium (1-2) | 17-18 | |
| » W: Jim McGlothlin (3-2) L: Jim Hannan (2-3) S: Hoyt Wilhelm (7) | Third | 6 out |
| Thursday, May 15 |
| Former Senator Shag Shaughnessy dies in Montreal, PQ at the age of 87. |
| Friday, May 16 |
| » Lost to White Sox (14-13), 7-6 | Comiskey Park I (0-1) | 17-19 | Lost 2 |
| » W: Dan Osinski (1-0) L: Casey Cox (2-1) | Fourth | 7½ out |
| Saturday, May 17 |
| » Lost to White Sox (15-13), 6-0 | Comiskey Park I (0-2) | 17-20 | Lost 3 |
| » W: Jerry Nyman (1-0) L: Camilo Pascual (2-4) | Fourth | 8½ out |
| Sunday, May 18 |
| » Defeated White Sox (15-14), 3-2 | Comiskey Park I (1-2) | 18-20 | |
| » W: Dave Baldwin (2-1) L: Joe Horlen (3-3) S: Dennis Higgins (8) | Fourth | 8 out |
| » Defeated White Sox (15-15), 3-2 | Comiskey Park I (2-2) | 19-20 | Won 2 |
| » W: Dick Bosman (4-2) L: Gary Peters (3-5) S: Dennis Higgins (9) | Fourth | 8 out |
| Tuesday, May 20 |
| » Defeated Pilots (15-20), 6-5 | Robert F. Kennedy Stadium (10-5) | 20-20 | Won 3 |
| » W: Dennis Higgins (3-3) L: Marty Pattin (5-2) | Fourth | 7 out |
| Wednesday, May 21 |
| » Lost to Pilots (16-20), 6-2 | Robert F. Kennedy Stadium (10-6) | 20-21 | |
| » W: Gene Brabender (1-3) L: Joe Coleman (2-4) S: Diego Segui (5) | Fourth | 8 out |
| Thursday, May 22 |
| » Lost to Pilots (17-20), 7-6 | Robert F. Kennedy Stadium (10-7) | 20-22 | Lost 2 |
| » W: Diego Segui (4-2) L: Dennis Higgins (3-4) | Fourth | 9 out |
| Friday, May 23 |
| » Lost to Royals (18-21), 4-3 | Robert F. Kennedy Stadium (10-8) | 20-23 | Lost 3 |
| » W: Moe Drabowsky (4-3) L: Dennis Higgins (3-5) S: Dave Wickersham (3) | Fifth | 10 out |
| Saturday, May 24 |
| » Lost to Royals (19-21), 5-4 | Robert F. Kennedy Stadium (10-9) | 20-24 | Lost 4 |
| » W: Tom Burgmeier (2-0) L: Dave Baldwin (2-2) S: Wally Bunker (1) | Fifth | 11 out |
| Sunday, May 25 |
| » Lost to Royals (20-21), 3-2 | Robert F. Kennedy Stadium (10-10) | 20-25 | Lost 5 |
| » W: Dave Wickersham (2-1) L: Bob Humphreys (0-1) | Fifth | 12 out |
| Monday, May 26 |
| » Lost to Twins (24-16), 7-1 | Robert F. Kennedy Stadium (10-11) | 20-26 | Lost 6 |
| » W: Jim Perry (4-1) L: Joe Coleman (2-5) | Fifth | 12½ out |
| Tuesday, May 27 |
| » Defeated Twins (24-17), 5-1 | Robert F. Kennedy Stadium (11-11) | 21-26 | |
| » W: Barry Moore (3-1) L: Tom Hall (2-3) | Fifth | 11½ out |
| Wednesday, May 28 |
| » Defeated Twins (24-18), 4-3 | Robert F. Kennedy Stadium (12-11) | 22-26 | Won 2 |
| » W: Dennis Higgins (4-5) L: Jim Kaat (4-3) | Fourth | 11½ out |
| Friday, May 30 |
| » Defeated White Sox (18-20), 5-4 | Robert F. Kennedy Stadium (13-11) | 23-26 | Won 3 |
| » W: Darold Knowles (1-0) L: Cisco Carlos (0-1) | Fifth | 12 out |
| » Lost to White Sox (19-20), 8-5 | Robert F. Kennedy Stadium (13-12) | 23-27 | |
| » W: Cisco Carlos (1-1) L: Jim Shellenback (0-1) | Fifth | 12 out |
| Saturday, May 31 |
| » Defeated White Sox (19-21), 7-5 | Robert F. Kennedy Stadium (14-12) | 24-27 | |
| » W: Darold Knowles (2-0) L: Tommy John (3-3) | Fifth | 11 out |
| Sunday, June 1 |
| » Defeated White Sox (19-22), 9-2 | Robert F. Kennedy Stadium (15-12) | 25-27 | Won 2 |
| » W: Barry Moore (4-1) L: Jerry Nyman (2-1) | Fifth | 11 out |
| Monday, June 2 |
| » Defeated Royals (21-27), 7-6 | Municipal Stadium (1-0) | 26-27 | Won 3 |
| » W: Casey Cox (3-1) L: Roger Nelson (3-4) S: Dennis Higgins (10) | Fourth | 10½ out |
| » Major-league debuts: Dennis Paepke (Royals) |
| Tuesday, June 3 |
| » Lost to Royals (22-27), 5-3 | Municipal Stadium (1-1) | 26-28 | |
| » W: Wally Bunker (2-2) L: Jim Hannan (2-4) | Fourth | 11½ out |
| Wednesday, June 4 |
| » Defeated Royals (22-28), 3-1 | Municipal Stadium (2-1) | 27-28 | |
| » W: Joe Coleman (3-5) L: Dick Drago (3-3) | Fourth | 11½ out |
| Friday, June 6 |
| » Defeated Twins (28-21), 1-0 | Metropolitan Stadium (1-0) | 28-28 | Won 2 |
| » W: Barry Moore (5-1) L: Jim Kaat (5-4) S: Darold Knowles (1) | Fourth | 11½ out |
| Saturday, June 7 |
| » Lost to Twins (29-21), 10-1 | Metropolitan Stadium (1-1) | 28-29 | |
| » W: Dave Boswell (7-6) L: Jim Hannan (2-5) S: Bob Miller (3) | Fourth | 12½ out |
| Sunday, June 8 |
| » Defeated Twins (29-22), 7-5 | Metropolitan Stadium (2-1) | 29-29 | |
| » W: Casey Cox (4-1) L: Tom Hall (3-4) | Fifth | 11½ out |
| Tuesday, June 10 |
| » Lost to Athletics (26-24), 6-4 | Robert F. Kennedy Stadium (15-13) | 29-30 | |
| » W: Paul Lindblad (3-0) L: Dennis Higgins (4-6) S: Rollie Fingers (3) | Fourth | 12½ out |
| Wednesday, June 11 |
| » Lost to Athletics (27-24), 6-4 | Robert F. Kennedy Stadium (15-14) | 29-31 | Lost 2 |
| » W: Paul Lindblad (4-0) L: Frank Bertaina (1-3) S: Jim Roland (1) | Fifth | 12½ out |
| Thursday, June 12 |
| » Defeated Athletics (27-25), 4-1 | Robert F. Kennedy Stadium (16-14) | 30-31 | |
| » W: Jim Shellenback (1-1) L: George Lauzerique (2-1) | Fifth | 12 out |
| Former Senator Joe Engel dies in Chattanooga, TN at the age of 77. |
| Friday, June 13 |
| » Defeated Angels (18-36), 6-2 | Robert F. Kennedy Stadium (17-14) | 31-31 | Won 2 |
| » W: Bob Humphreys (1-1) L: Jim McGlothlin (5-5) S: Dennis Higgins (11) | Fourth | 12 out |
| Saturday, June 14 |
| » Lost to Angels (19-36), 3-2 | Robert F. Kennedy Stadium (17-15) | 31-32 | |
| » W: George Brunet (2-5) L: Joe Coleman (3-6) S: Hoyt Wilhelm (10) | Fourth | 13 out |
| Tuesday, June 17 |
| » Lost to Orioles (45-17), 5-1 | Robert F. Kennedy Stadium (17-16) | 31-33 | Lost 2 |
| » W: Mike Cuellar (7-5) L: Jim Shellenback (1-2) | Fourth | 15 out |
| Wednesday, June 18 |
| » Lost to Orioles (46-17), 3-1 | Robert F. Kennedy Stadium (17-17) | 31-34 | Lost 3 |
| » W: Jim Hardin (3-3) L: Barry Moore (5-2) S: Dick Hall (2) | Fourth | 16 out |
| Thursday, June 19 |
| » Lost to Orioles (47-17), 2-0 | Robert F. Kennedy Stadium (17-18) | 31-35 | Lost 4 |
| » W: Dave McNally (10-0) L: Dennis Higgins (4-7) | Fifth | 17 out |
| Friday, June 20 |
| » Defeated Tigers (34-26), 7-2 | Tiger Stadium (2-1) | 32-35 | |
| » W: Darold Knowles (3-0) L: Don McMahon (1-4) | Fourth | 16½ out |
| Saturday, June 21 |
| » Lost to Tigers (35-26), 9-5 | Tiger Stadium (2-2) | 32-36 | |
| » W: Mickey Lolich (8-1) L: Bob Humphreys (1-2) | Fifth | 17½ out |
| Sunday, June 22 |
| » Defeated Tigers (35-27), 9-4 | Tiger Stadium (3-2) | 33-36 | |
| » W: Dennis Higgins (5-7) L: Pat Dobson (2-5) | Fourth | 16½ out |
| » Defeated Tigers (35-28), 9-5 | Tiger Stadium (4-2) | 34-36 | Won 2 |
| » W: Barry Moore (6-2) L: Joe Sparma (4-3) | Fourth | 16½ out |
| Monday, June 23 |
| » Lost to Orioles (51-19), 5-3 | Memorial Stadium (1-4) | 34-37 | |
| » W: Jim Palmer (9-2) L: Darold Knowles (3-1) S: Pete Richert (6) | Fourth | 17½ out |
| Tuesday, June 24 |
| » Lost to Orioles (52-19), 6-3 | Memorial Stadium (1-5) | 34-38 | Lost 2 |
| » W: Dick Hall (4-2) L: Jim Shellenback (1-3) | Fourth | 18½ out |
| Wednesday, June 25 |
| » Defeated Orioles (52-20), 11-8 | Memorial Stadium (2-5) | 35-38 | |
| » W: Bob Humphreys (2-2) L: Jim Hardin (3-4) S: Darold Knowles (2) | Fourth | 17½ out |
| Friday, June 27 |
| » Lost to Red Sox (43-28), 4-2 | Robert F. Kennedy Stadium (17-19) | 35-39 | |
| » W: Bill Landis (4-1) L: Barry Moore (6-3) S: Sparky Lyle (6) | Fourth | 18½ out |
| Saturday, June 28 |
| » Defeated Red Sox (43-29), 4-3 | Robert F. Kennedy Stadium (18-19) | 36-39 | |
| » W: Darold Knowles (4-1) L: Vicente Romo (3-5) | Fourth | 18½ out |
| Sunday, June 29 |
| » Defeated Red Sox (43-30), 5-4 | Robert F. Kennedy Stadium (19-19) | 37-39 | Won 2 |
| » W: Dennis Higgins (6-7) L: Bill Landis (4-2) | Fourth | 17½ out |
| » Defeated Red Sox (43-31), 11-4 | Robert F. Kennedy Stadium (20-19) | 38-39 | Won 3 |
| » W: Joe Coleman (4-6) L: Sonny Siebert (6-7) | Fourth | 17½ out |
| Tuesday, July 1 |
| » Defeated Indians (29-45), 4-1 | Cleveland Stadium (4-0) | 39-39 | Won 4 |
| » W: Casey Cox (5-1) L: Steve Hargan (1-6) | Fourth | 16 out |
| » Defeated Indians (29-46), 7-5 | Cleveland Stadium (5-0) | 40-39 | Won 5 |
| » W: Dennis Higgins (7-7) L: Mike Paul (1-7) S: Darold Knowles (3) | Fourth | 16 out |
| Wednesday, July 2 |
| » Defeated Indians (29-47), 5-1 | Cleveland Stadium (6-0) | 41-39 | Won 6 |
| » W: Dick Bosman (5-2) L: Sam McDowell (10-7) S: Darold Knowles (4) | Fourth | 15 out |
| Thursday, July 3 |
| » Lost to Indians (30-47), 7-2 | Cleveland Stadium (6-1) | 41-40 | |
| » W: Luis Tiant (7-8) L: Camilo Pascual (2-5) | Fourth | 15½ out |
| Friday, July 4 |
| » Defeated Red Sox (43-35), 5-1 | Fenway Park (2-0) | 42-40 | |
| » W: Jim Hannan (3-5) L: Lee Stange (3-5) S: Dennis Higgins (12) | Fourth | 15 out |
| » Lost to Red Sox (44-35), 7-4 | Fenway Park (2-1) | 42-41 | |
| » W: Mike Nagy (4-1) L: Joe Coleman (4-7) S: Sparky Lyle (7) | Fourth | 15 out |
| Former Senator Lew Drill dies in St.Paul, MN at the age of 93. |
| Saturday, July 5 |
| » Defeated Red Sox (44-36), 6-2 | Fenway Park (3-1) | 43-41 | |
| » W: Barry Moore (7-3) L: Ray Jarvis (3-5) | Fourth | 15½ out |
| » Lost to Red Sox (45-36), 11-4 | Fenway Park (3-2) | 43-42 | |
| » W: Sonny Siebert (7-7) L: Jim Shellenback (1-4) | Fourth | 15½ out |
| Sunday, July 6 |
| » Defeated Red Sox (45-37), 5-0 | Fenway Park (4-2) | 44-42 | |
| » W: Dick Bosman (6-2) L: Bill Landis (4-4) | Fourth | 14½ out |
| Monday, July 7 |
| » Defeated Indians (32-50), 7-2 | Robert F. Kennedy Stadium (21-19) | 45-42 | Won 2 |
| » W: Casey Cox (6-1) L: Luis Tiant (7-9) | Fourth | 14 out |
| Tuesday, July 8 |
| » Lost to Indians (33-50), 6-5 | Robert F. Kennedy Stadium (21-20) | 45-43 | |
| » W: Horacio Pina (3-2) L: Dennis Higgins (7-8) S: Stan Williams (5) | Fourth | 15½ out |
| Wednesday, July 9 |
| » Defeated Indians (33-51), 3-0 | Robert F. Kennedy Stadium (22-20) | 46-43 | |
| » W: Joe Coleman (5-7) L: Steve Hargan (2-7) | Fourth | 15½ out |
| Friday, July 11 |
| » Lost to Yankees (41-47), 4-3 | Robert F. Kennedy Stadium (22-21) | 46-44 | |
| » W: Mel Stottlemyre (13-6) L: Barry Moore (7-4) | Fourth | 15½ out |
| Saturday, July 12 |
| » Lost to Yankees (42-47), 3-1 | Robert F. Kennedy Stadium (22-22) | 46-45 | Lost 2 |
| » W: Bill Burbach (6-7) L: Dick Bosman (6-3) S: Jack Aker (7) | Fourth | 16½ out |
| Sunday, July 13 |
| » Defeated Yankees (42-48), 5-4 | Robert F. Kennedy Stadium (23-22) | 47-45 | |
| » W: Casey Cox (7-1) L: Fritz Peterson (9-11) | Fourth | 16 out |
| » Defeated Yankees (42-49), 10-1 | Robert F. Kennedy Stadium (24-22) | 48-45 | Won 2 |
| » W: Jim Shellenback (2-4) L: Al Downing (1-3) | Fourth | 16 out |
| Monday, July 14 |
| » Defeated Tigers (47-39), 3-0 | Robert F. Kennedy Stadium (25-22) | 49-45 | Won 3 |
| » W: Joe Coleman (6-7) L: Joe Sparma (5-7) | Fourth | 15½ out |
| Tuesday, July 15 |
| » Defeated Tigers (47-40), 7-3 | Robert F. Kennedy Stadium (26-22) | 50-45 | Won 4 |
| » W: Barry Moore (8-4) L: John Hiller (2-3) S: Dave Baldwin (3) | Fourth | 15½ out |
| Wednesday, July 16 |
| » Lost to Tigers (48-40), 3-0 | Robert F. Kennedy Stadium (26-23) | 50-46 | |
| » W: Mickey Lolich (13-2) L: Dick Bosman (6-4) | Fourth | 16 out |
| Thursday, July 17 |
| » Lost to Tigers (49-40), 4-3 | Robert F. Kennedy Stadium (26-24) | 50-47 | Lost 2 |
| » W: Earl Wilson (8-7) L: Casey Cox (7-2) S: Don McMahon (8) | Fourth | 17 out |
| Friday, July 18 |
| » Lost to Yankees (44-51), 5-0 | Yankee Stadium (1-3) | 50-48 | Lost 3 |
| » W: Fritz Peterson (10-11) L: Jim Shellenback (2-5) | Fourth | 17 out |
| Saturday, July 19 |
| » Lost to Yankees (45-51), 9-0 | Yankee Stadium (1-4) | 50-49 | Lost 4 |
| » W: Mel Stottlemyre (14-7) L: Barry Moore (8-5) | Fourth | 16½ out |
| » Defeated Yankees (45-52), 4-0 | Yankee Stadium (2-4) | 51-49 | |
| » W: Joe Coleman (7-7) L: Stan Bahnsen (5-11) | Fourth | 16½ out |
| Sunday, July 20 |
| » Lost to Yankees (46-52), 3-2 | Yankee Stadium (2-5) | 51-50 | |
| » W: Jack Aker (5-2) L: Casey Cox (7-3) | Fourth | 16½ out |
| Thursday, July 24 |
| » Lost to Athletics (54-39), 2-1 | Oakland-Alameda County Stadium (0-3) | 51-51 | Lost 2 |
| » W: Catfish Hunter (9-7) L: Joe Coleman (7-8) | Fourth | 17½ out |
| Friday, July 25 |
| » Lost to Athletics (55-39), 4-3 | Oakland-Alameda County Stadium (0-4) | 51-52 | Lost 3 |
| » W: Chuck Dobson (12-7) L: Darold Knowles (4-2) S: Rollie Fingers (10) | Fourth | 18½ out |
| Saturday, July 26 |
| » Defeated Athletics (55-40), 3-1 | Oakland-Alameda County Stadium (1-4) | 52-52 | |
| » W: Jim Shellenback (3-5) L: Blue Moon Odom (14-4) S: Darold Knowles (5) | Fourth | 18½ out |
| Sunday, July 27 |
| » Lost to Athletics (56-40), 7-2 | Oakland-Alameda County Stadium (1-5) | 52-53 | |
| » W: Lew Krausse (6-4) L: Dick Bosman (6-5) | Fourth | 19½ out |
| Tuesday, July 29 |
| » Defeated Pilots (42-58), 4-2 | Sick's Stadium (1-3) | 53-53 | |
| » W: Joe Coleman (8-8) L: Gene Brabender (8-8) | Fourth | 19½ out |
| Wednesday, July 30 |
| » Lost to Pilots (43-58), 4-3 | Sick's Stadium (1-4) | 53-54 | |
| » W: Diego Segui (8-4) L: Casey Cox (7-4) S: John Gelnar (2) | Fourth | 20½ out |
| Thursday, July 31 |
| » Defeated Pilots (43-59), 7-6 | Sick's Stadium (2-4) | 54-54 | |
| » W: Jim Shellenback (4-5) L: Fred Talbot (5-4) S: Darold Knowles (6) | Fourth | 20½ out |
| Friday, August 1 |
| » Defeated Angels (40-62), 5-3 | Anaheim Stadium (2-2) | 55-54 | Won 2 |
| » W: Dick Bosman (7-5) L: Ken Tatum (3-1) S: Darold Knowles (7) | Fourth | 19½ out |
| Saturday, August 2 |
| » Defeated Angels (40-63), 8-7 | Anaheim Stadium (3-2) | 56-54 | Won 3 |
| » W: Dennis Higgins (8-8) L: Pedro Borbon (2-2) S: Bob Humphreys (2) | Fourth | 19½ out |
| Sunday, August 3 |
| » Lost to Angels (41-63), 3-2 | Anaheim Stadium (3-3) | 56-55 | |
| » W: Ken Tatum (4-1) L: Casey Cox (7-5) | Fourth | 19½ out |
| Tuesday, August 5 |
| » Lost to White Sox (43-65), 11-4 | Comiskey Park I (2-3) | 56-56 | Lost 2 |
| » W: Billy Wynne (4-2) L: Jim Shellenback (4-6) S: Wilbur Wood (8) | Fourth | 20 out |
| Wednesday, August 6 |
| » Defeated White Sox (43-66), 4-3 | County Stadium (1-0) | 57-56 | |
| » W: Dennis Higgins (9-8) L: Wilbur Wood (7-8) | Fourth | 20 out |
| Friday, August 8 |
| » Defeated Pilots (45-64), 10-3 | Robert F. Kennedy Stadium (27-24) | 58-56 | Won 2 |
| » W: Joe Coleman (9-8) L: George Brunet (6-9) S: Dave Baldwin (4) | Fourth | 20½ out |
| Saturday, August 9 |
| » Lost to Pilots (46-64), 8-6 | Robert F. Kennedy Stadium (27-25) | 58-57 | |
| » W: Bob Locker (5-6) L: Dave Baldwin (2-3) | Fourth | 21½ out |
| Sunday, August 10 |
| » Defeated Pilots (46-65), 7-5 | Robert F. Kennedy Stadium (28-25) | 59-57 | |
| » W: Darold Knowles (5-2) L: John Gelnar (2-9) S: Joe Coleman (1) | Fourth | 21½ out |
| Monday, August 11 |
| » Defeated Royals (45-68), 2-1 | Robert F. Kennedy Stadium (29-25) | 60-57 | Won 2 |
| » W: Dick Bosman (8-5) L: Jim Rooker (2-10) | Fourth | 20½ out |
| Tuesday, August 12 |
| » Lost to Royals (46-68), 6-3 | Robert F. Kennedy Stadium (29-26) | 60-58 | |
| » W: Wally Bunker (7-9) L: Joe Coleman (9-9) S: Moe Drabowsky (11) | Fourth | 21½ out |
| Wednesday, August 13 |
| » Lost to Royals (47-68), 7-3 | Robert F. Kennedy Stadium (29-27) | 60-59 | Lost 2 |
| » W: Dick Drago (6-10) L: Jim Miles (0-1) | Fourth | 22½ out |
| Friday, August 15 |
| » Lost to Twins (70-47), 2-0 | Robert F. Kennedy Stadium (29-28) | 60-60 | Lost 3 |
| » W: Jim Perry (14-5) L: Jim Shellenback (4-7) S: Ron Perranoski (22) | Fifth | 23½ out |
| Saturday, August 16 |
| » Defeated Twins (70-48), 6-5 | Robert F. Kennedy Stadium (30-28) | 61-60 | |
| » W: Darold Knowles (6-2) L: Jim Kaat (11-10) | Fourth | 23½ out |
| Sunday, August 17 |
| » Lost to Twins (71-48), 4-3 | Robert F. Kennedy Stadium (30-29) | 61-61 | |
| » W: Ron Perranoski (8-6) L: Dennis Higgins (9-9) | Fifth | 24½ out |
| Tuesday, August 19 |
| » Defeated White Sox (46-75), 3-1 | Robert F. Kennedy Stadium (31-29) | 62-61 | |
| » W: Casey Cox (8-5) L: Joe Horlen (8-14) S: Darold Knowles (8) | Fifth | 25 out |
| Former Senator Alex Carrasquel dies in Caracas, Venezuela at the age of 58. |
| Wednesday, August 20 |
| » Defeated White Sox (46-76), 4-1 | Robert F. Kennedy Stadium (32-29) | 63-61 | Won 2 |
| » W: Dick Bosman (9-5) L: Tommy John (6-10) S: Darold Knowles (9) | Fourth | 24 out |
| » Major-league debuts: Dick Smith (Senators) |
| Friday, August 22 |
| » Lost to Royals (51-71), 3-2 | Municipal Stadium (2-2) | 63-62 | |
| » W: Jim Rooker (4-10) L: Joe Coleman (9-10) | Fourth | 24½ out |
| Saturday, August 23 |
| » Defeated Royals (51-72), 4-2 | Municipal Stadium (3-2) | 64-62 | |
| » W: Jim Hannan (4-5) L: Wally Bunker (8-10) S: Dennis Higgins (13) | Fourth | 23½ out |
| Sunday, August 24 |
| » Defeated Royals (51-73), 10-3 | Municipal Stadium (4-2) | 65-62 | Won 2 |
| » W: Casey Cox (9-5) L: Roger Nelson (6-12) | Fourth | 22 out |
| Monday, August 25 |
| » Defeated Twins (75-51), 7-3 | Metropolitan Stadium (3-1) | 66-62 | Won 3 |
| » W: Dick Bosman (10-5) L: Jim Kaat (11-11) S: Darold Knowles (10) | Fourth | 21½ out |
| Tuesday, August 26 |
| » Lost to Twins (76-51), 6-4 | Metropolitan Stadium (3-2) | 66-63 | |
| » W: Dave Boswell (14-9) L: Barry Moore (8-6) S: Ron Perranoski (24) | Fourth | 21½ out |
| Wednesday, August 27 |
| » Lost to Twins (77-51), 4-2 | Metropolitan Stadium (3-3) | 66-64 | Lost 2 |
| » W: Jim Perry (16-5) L: Joe Coleman (9-11) | Fourth | 22½ out |
| Friday, August 29 |
| » Lost to Athletics (74-54), 5-0 | Robert F. Kennedy Stadium (32-30) | 66-65 | Lost 3 |
| » W: Jim Nash (7-7) L: Barry Moore (8-7) S: Paul Lindblad (7) | Fourth | 22½ out |
| Saturday, August 30 |
| » Defeated Athletics (74-55), 11-3 | Robert F. Kennedy Stadium (33-30) | 67-65 | |
| » W: Dick Bosman (11-5) L: Lew Krausse (7-7) S: Bob Humphreys (3) | Fourth | 22½ out |
| Sunday, August 31 |
| » Defeated Athletics (74-56), 8-3 | Robert F. Kennedy Stadium (34-30) | 68-65 | Won 2 |
| » W: Casey Cox (10-5) L: Catfish Hunter (9-13) S: Dennis Higgins (14) | Fourth | 22½ out |
| Monday, September 1 |
| » Defeated Angels (55-74), 4-0 | Robert F. Kennedy Stadium (35-30) | 69-65 | Won 3 |
| » W: Joe Coleman (10-11) L: Tom Murphy (8-13) | Fourth | 23 out |
| » Lost to Angels (56-74), 8-7 | Robert F. Kennedy Stadium (35-31) | 69-66 | |
| » W: Steve Kealey (2-0) L: Dave Baldwin (2-4) S: Ken Tatum (15) | Fourth | 23 out |
| » Major-league debuts: Lloyd Allen (Angels) |
| Tuesday, September 2 |
| » Defeated Angels (56-75), 2-0 | Robert F. Kennedy Stadium (36-31) | 70-66 | |
| » W: Jim Hannan (5-5) L: Andy Messersmith (13-9) | Fourth | 21½ out |
| » Defeated Angels (56-76), 3-2 | Robert F. Kennedy Stadium (37-31) | 71-66 | Won 2 |
| » W: Cisco Carlos (5-3) L: Jim McGlothlin (7-13) S: Bob Humphreys (4) | Fourth | 21½ out |
| Friday, September 5 |
| » Lost to Red Sox (73-62), 9-8 | Fenway Park (4-3) | 71-67 | |
| » W: Sonny Siebert (10-11) L: Bob Humphreys (2-3) | Fourth | 23 out |
| » Major-league debuts: Toby Harrah (Senators) |
| Saturday, September 6 |
| » Lost to Red Sox (74-62), 9-5 | Fenway Park (4-4) | 71-68 | Lost 2 |
| » W: Lee Stange (6-7) L: Joe Coleman (10-12) S: Sonny Siebert (3) | Fourth | 23 out |
| Sunday, September 7 |
| » Defeated Red Sox (74-63), 3-2 | Fenway Park (5-4) | 72-68 | |
| » W: Casey Cox (11-5) L: Jim Lonborg (7-9) S: Darold Knowles (11) | Fourth | 23 out |
| Tuesday, September 9 |
| » Lost to Orioles (96-45), 6-1 | Memorial Stadium (2-6) | 72-69 | |
| » W: Mike Cuellar (21-10) L: Cisco Carlos (5-4) | Fourth | 25 out |
| » Lost to Orioles (97-45), 3-2 | Memorial Stadium (2-7) | 72-70 | Lost 2 |
| » W: Tom Phoebus (13-6) L: Joe Coleman (10-13) S: Eddie Watt (14) | Fourth | 25 out |
| Wednesday, September 10 |
| » Defeated Yankees (70-71), 6-1 | Robert F. Kennedy Stadium (38-31) | 73-70 | |
| » W: Dick Bosman (12-5) L: Mel Stottlemyre (18-13) | Fourth | 25 out |
| » Major-league debuts: Ron Blomberg (Yankees) |
| Thursday, September 11 |
| » Defeated Yankees (70-72), 7-3 | Robert F. Kennedy Stadium (39-31) | 74-70 | Won 2 |
| » W: Jim Hannan (6-5) L: Stan Bahnsen (9-14) S: Darold Knowles (12) | Fourth | 25 out |
| Friday, September 12 |
| » Defeated Tigers (82-62), 4-3 | Robert F. Kennedy Stadium (40-31) | 75-70 | Won 3 |
| » W: Casey Cox (12-5) L: Earl Wilson (12-10) | Fourth | 25 out |
| Saturday, September 13 |
| » Defeated Tigers (82-63), 11-6 | Robert F. Kennedy Stadium (41-31) | 76-70 | Won 4 |
| » W: Darold Knowles (7-2) L: Tom Timmermann (3-3) | Fourth | 25 out |
| Sunday, September 14 |
| » Lost to Tigers (83-63), 7-4 | Robert F. Kennedy Stadium (41-32) | 76-71 | |
| » W: Pat Dobson (5-10) L: Jan Dukes (0-1) S: John Hiller (4) | Fourth | 26 out |
| Monday, September 15 |
| » Defeated Orioles (102-46), 3-2 | Robert F. Kennedy Stadium (42-32) | 77-71 | |
| » W: Bob Humphreys (3-3) L: Jim Palmer (14-3) | Fourth | 25 out |
| Tuesday, September 16 |
| » Lost to Orioles (103-46), 1-0 | Robert F. Kennedy Stadium (42-33) | 77-72 | |
| » W: Dave McNally (19-6) L: Jim Hannan (6-6) S: Eddie Watt (16) | Fourth | 26 out |
| Wednesday, September 17 |
| » Lost to Yankees (74-75), 2-1 | Yankee Stadium (2-6) | 77-73 | Lost 2 |
| » W: Fritz Peterson (16-15) L: Casey Cox (12-6) | Fourth | 26½ out |
| Thursday, September 18 |
| » Lost to Yankees (75-75), 4-3 | Yankee Stadium (2-7) | 77-74 | Lost 3 |
| » W: Mel Stottlemyre (19-13) L: Barry Moore (8-8) | Fourth | 27 out |
| Former Senator Joe Grace dies in Murphysboro, IL at the age of 56. |
| Saturday, September 20 |
| » Defeated Indians (60-92), 5-3 | Cleveland Stadium (7-1) | 78-74 | |
| » W: Darold Knowles (8-2) L: Steve Hargan (5-14) S: Dennis Higgins (15) | Fourth | 27½ out |
| Sunday, September 21 |
| » Lost to Indians (61-92), 4-3 | Cleveland Stadium (7-2) | 78-75 | |
| » W: Phil Hennigan (2-1) L: Jan Dukes (0-2) | Fourth | 28 out |
| Tuesday, September 23 |
| » Major-league debuts: Bob Stinson (Dodgers) |
| Wednesday, September 24 |
| » Defeated Tigers (86-68), 8-4 | Tiger Stadium (5-2) | 79-75 | |
| » W: Jim Hannan (7-6) L: Denny McLain (23-9) S: Jim Shellenback (1) | Fourth | 27 out |
| » Defeated Tigers (86-69), 7-4 | Tiger Stadium (6-2) | |