| Monday, January 27 |
| Future Red Sox Phil Plantier is born in Manchester, NH. |
| Tuesday, March 4 |
| Future Red Sox Lee Tinsley is born in Shelbyville, KY. |
| Friday, March 21 |
| Former Red Sox Pinky Higgins dies in Dallas, TX at the age of 60. |
| Friday, April 4 |
| Future Red Sox Carlos Reyes is born in Miami, FL. |
| Monday, April 7 |
| » Major-league debuts: Bob Didier (Braves) |
| Tuesday, April 8 |
| » Defeated Orioles (0-1), 5-4 | Memorial Stadium (1-0) | 1-0 | |
| » W: Bill Landis (1-0) L: Mike Adamson (0-1) S: Juan Pizarro (1) | First | -- |
| Thursday, April 10 |
| » Lost to Orioles (1-1), 2-1 | Memorial Stadium (1-1) | 1-1 | |
| » W: Dave Leonhard (1-0) L: Juan Pizarro (0-1) | Third | 1 out |
| Friday, April 11 |
| » Defeated Indians (0-3), 2-1 | Cleveland Stadium (1-0) | 2-1 | |
| » W: Bill Landis (2-0) L: Jack Hamilton (0-1) S: Juan Pizarro (2) | Second | ½ out |
| » Major-league debuts: Billy Conigliaro (Red Sox) |
| Saturday, April 12 |
| » Defeated Indians (0-4), 5-3 | Cleveland Stadium (2-0) | 3-1 | Won 2 |
| » W: Bill Landis (3-0) L: Stan Williams (0-1) | First | -- |
| Sunday, April 13 |
| » Defeated Indians (0-5), 3-1 | Cleveland Stadium (3-0) | 4-1 | Won 3 |
| » W: Lee Stange (1-0) L: Luis Tiant (0-2) | First | -- |
| Monday, April 14 |
| » Defeated Orioles (4-3), 5-3 | Fenway Park (1-0) | 5-1 | Won 4 |
| » W: Ray Culp (1-0) L: Mike Cuellar (0-1) S: Sparky Lyle (1) | First | -- |
| Future Red Sox Brad Pennington is born in Salem, IN. |
| Tuesday, April 15 |
| » Lost to Orioles (5-3), 10-5 | Fenway Park (1-1) | 5-2 | |
| » W: Pete Richert (1-0) L: Bill Landis (3-1) | First | -- |
| » Major-league debuts: Ray Jarvis and Syd O'Brien (Red Sox) |
| Wednesday, April 16 |
| » Lost to Orioles (6-3), 11-8 | Fenway Park (1-2) | 5-3 | Lost 2 |
| » W: Dave Leonhard (2-0) L: Ken Brett (0-1) S: Dick Hall (1) | Second | ½ out |
| Thursday, April 17 |
| » Lost to Orioles (7-3), 9-5 | Fenway Park (1-3) | 5-4 | Lost 3 |
| » W: Jim Palmer (2-0) L: Lee Stange (1-1) S: Eddie Watt (1) | Third | 1½ out |
| Friday, April 18 |
| » Defeated Indians (1-8), 10-7 | Fenway Park (2-3) | 6-4 | |
| » W: Ray Culp (2-0) L: Luis Tiant (0-3) S: Bill Landis (1) | Third | 1½ out |
| Sunday, April 20 |
| » Defeated Indians (1-9), 9-4 | Fenway Park (3-3) | 7-4 | Won 2 |
| » W: Ray Jarvis (1-0) L: Steve Hargan (0-1) | Second | 1½ out |
| Monday, April 21 |
| » Lost to Yankees (7-5), 6-4 | Fenway Park (3-4) | 7-5 | |
| » W: Mel Stottlemyre (4-0) L: Lee Stange (1-2) S: Lindy McDaniel (1) | Third | 1½ out |
| » Major-league debuts: Mike Nagy (Red Sox) |
| Tuesday, April 22 |
| » Defeated Yankees (7-6), 8-3 | Fenway Park (4-4) | 8-5 | |
| » W: Ray Culp (3-0) L: Stan Bahnsen (0-4) | Third | 1½ out |
| Wednesday, April 23 |
| » Lost to Senators (7-10), 9-3 | Fenway Park (4-5) | 8-6 | |
| » W: Joe Coleman (2-2) L: Sonny Siebert (0-2) S: Dennis Higgins (5) | Third | 2½ out |
| Friday, April 25 |
| » Defeated Tigers (8-7), 5-4 | Tiger Stadium (1-0) | 9-6 | |
| » W: Jim Lonborg (1-0) L: Mickey Lolich (2-1) S: Vicente Romo (1) | Second | 2 out |
| Saturday, April 26 |
| » Defeated Tigers (8-8), 7-4 | Tiger Stadium (2-0) | 10-6 | Won 2 |
| » W: Ray Culp (4-0) L: Joe Sparma (2-1) | Second | 2 out |
| » Major-league debuts: Fred Scherman (Tigers) |
| Future Red Sox Ricky Trlicek is born in Houston, TX. |
| Sunday, April 27 |
| » Lost to Tigers (9-8), 7-3 | Tiger Stadium (2-1) | 10-7 | |
| » W: Denny McLain (3-3) L: Sonny Siebert (0-3) S: Pat Dobson (1) | Second | 2½ out |
| Monday, April 28 |
| » Lost to Yankees (11-8), 1-0 | Yankee Stadium (0-1) | 10-8 | Lost 2 |
| » W: Fritz Peterson (3-2) L: Ray Jarvis (1-1) | Third | 3 out |
| Tuesday, April 29 |
| » Defeated Yankees (11-9), 2-1 | Yankee Stadium (1-1) | 11-8 | |
| » W: Mike Nagy (1-0) L: Mel Stottlemyre (5-1) S: Sparky Lyle (2) | Second | 2½ out |
| Wednesday, April 30 |
| » Lost to Senators (12-11), 1-0 | Robert F. Kennedy Stadium (0-1) | 11-9 | |
| » W: Jim Hannan (2-1) L: Lee Stange (1-3) S: Dennis Higgins (7) | Second | 3½ out |
| Thursday, May 1 |
| » Lost to Senators (13-11), 7-6 | Robert F. Kennedy Stadium (0-2) | 11-10 | Lost 2 |
| » W: Casey Cox (2-0) L: Ray Culp (4-1) S: Dave Baldwin (1) | Third | 3½ out |
| Friday, May 2 |
| » Defeated Tigers (11-11), 3-2 | Fenway Park (5-5) | 12-10 | |
| » W: Sonny Siebert (1-3) L: Dick Radatz (1-1) S: Sparky Lyle (3) | Third | 3½ out |
| Saturday, May 3 |
| » Defeated Tigers (11-12), 7-5 | Fenway Park (6-5) | 13-10 | Won 2 |
| » W: Fred Wenz (1-0) L: Don McMahon (0-1) | Third | 3½ out |
| Sunday, May 4 |
| » Defeated Tigers (11-13), 4-2 | Fenway Park (7-5) | 14-10 | Won 3 |
| » W: Sparky Lyle (1-0) L: Don McMahon (0-2) | Third | 4 out |
| Monday, May 5 |
| Former Red Sox Eddie Cicotte dies in Detroit, MI at the age of 85. |
| Tuesday, May 6 |
| » Defeated Pilots (8-16), 12-2 | Sick's Stadium (1-0) | 15-10 | Won 4 |
| » W: Ray Culp (5-1) L: Gene Brabender (0-3) | Second | 3 out |
| Wednesday, May 7 |
| » Defeated Pilots (8-17), 5-4 | Sick's Stadium (2-0) | 16-10 | Won 5 |
| » W: Sonny Siebert (2-3) L: Gary Bell (1-3) S: Vicente Romo (2) | Second | 2 out |
| Friday, May 9 |
| » Defeated Angels (9-15), 7-2 | Anaheim Stadium (1-0) | 17-10 | Won 6 |
| » W: Sparky Lyle (2-0) L: Hoyt Wilhelm (2-2) S: Vicente Romo (3) | Second | 2 out |
| Saturday, May 10 |
| » Defeated Angels (9-16), 6-3 | Anaheim Stadium (2-0) | 18-10 | Won 7 |
| » W: Sparky Lyle (3-0) L: Clyde Wright (0-2) S: Vicente Romo (4) | Second | 2 out |
| Future Red Sox Pete Schourek is born in Austin, TX. |
| Sunday, May 11 |
| » Defeated Angels (9-17), 7-3 | Anaheim Stadium (3-0) | 19-10 | Won 8 |
| » W: Sonny Siebert (3-3) L: Rudy May (1-3) S: Vicente Romo (5) | Second | 2 out |
| Tuesday, May 13 |
| » Lost to Athletics (20-10), 5-4 | Oakland-Alameda County Stadium (0-1) | 19-11 | |
| » W: Paul Lindblad (2-0) L: Vicente Romo (1-2) S: Rollie Fingers (1) | Second | 2 out |
| Wednesday, May 14 |
| » Defeated Athletics (20-11), 2-1 | Oakland-Alameda County Stadium (1-1) | 20-11 | |
| » W: Ray Culp (6-1) L: Chuck Dobson (3-4) | Second | 2 out |
| Friday, May 16 |
| » Lost to Pilots (14-18), 10-9 | Fenway Park (7-6) | 20-12 | |
| » W: Jim Bouton (1-0) L: Vicente Romo (1-3) S: John O'Donoghue (2) | Second | 2½ out |
| Saturday, May 17 |
| » Defeated Pilots (14-19), 6-1 | Fenway Park (8-6) | 21-12 | |
| » W: Mike Nagy (2-0) L: Gary Bell (2-4) | Second | 2½ out |
| Sunday, May 18 |
| » Lost to Pilots (15-19), 9-6 | Fenway Park (8-7) | 21-13 | |
| » W: Mike Marshall (3-4) L: Ray Culp (6-2) S: Diego Segui (4) | Second | 3½ out |
| Wednesday, May 21 |
| » Defeated Angels (11-23), 5-2 | Fenway Park (9-7) | 22-13 | |
| » W: Jim Lonborg (2-0) L: Jim McGlothlin (3-3) S: Sparky Lyle (4) | Second | 2½ out |
| » Defeated Angels (11-24), 8-3 | Fenway Park (10-7) | 23-13 | Won 2 |
| » W: Sonny Siebert (4-3) L: Rudy May (1-5) S: Vicente Romo (6) | Second | 2½ out |
| Thursday, May 22 |
| » Defeated Angels (11-25), 4-3 | Fenway Park (11-7) | 24-13 | Won 3 |
| » W: Ray Jarvis (2-1) L: Hoyt Wilhelm (2-4) | Second | 2½ out |
| Future Red Sox Vaughn Eshelman is born in Philadelphia, PA. |
| Friday, May 23 |
| » Defeated White Sox (16-17), 4-2 | Comiskey Park I (1-0) | 25-13 | Won 4 |
| » W: Ray Culp (7-2) L: Joe Horlen (3-4) S: Vicente Romo (7) | Second | 2½ out |
| Saturday, May 24 |
| » Lost to White Sox (17-17), 9-3 | Comiskey Park I (1-1) | 25-14 | |
| » W: Gary Peters (4-5) L: Lee Stange (1-4) | Second | 3½ out |
| Sunday, May 25 |
| » Defeated White Sox (17-18), 1-0 | Comiskey Park I (2-1) | 26-14 | |
| » W: Jim Lonborg (3-0) L: Tommy John (3-2) S: Vicente Romo (8) | Second | 3½ out |
| Tuesday, May 27 |
| » Lost to Royals (21-21), 5-4 | Municipal Stadium (0-1) | 26-15 | |
| » W: Dick Drago (3-2) L: Sonny Siebert (4-4) S: Dave Wickersham (4) | Second | 3½ out |
| Wednesday, May 28 |
| » Defeated Royals (21-22), 4-3 | Municipal Stadium (1-1) | 27-15 | |
| » W: Ray Culp (8-2) L: Mike Hedlund (2-3) | Second | 3½ out |
| Thursday, May 29 |
| » Defeated Royals (21-23), 8-6 | Municipal Stadium (2-1) | 28-15 | Won 2 |
| » W: Sparky Lyle (4-0) L: Moe Drabowsky (4-4) S: Ray Jarvis (1) | Second | 3 out |
| Future Red Sox Toby Borland is born in Ruston, LA. |
| Friday, May 30 |
| » Defeated Twins (24-19), 3-2 | Fenway Park (12-7) | 29-15 | Won 3 |
| » W: Jim Lonborg (4-0) L: Dave Boswell (5-6) S: Vicente Romo (9) | Second | 3 out |
| Saturday, May 31 |
| » Lost to Twins (25-19), 10-4 | Fenway Park (12-8) | 29-16 | |
| » W: Dick Woodson (3-1) L: Sonny Siebert (4-5) S: Ron Perranoski (10) | Second | 3 out |
| Future Red Sox Tim Van Egmond is born in Shreveport, LA. |
| Sunday, June 1 |
| » Defeated Twins (25-20), 5-2 | Fenway Park (13-8) | 30-16 | |
| » W: Ray Culp (9-2) L: Jim Perry (4-2) S: Sparky Lyle (5) | Second | 3 out |
| Monday, June 2 |
| » Lost to White Sox (20-22), 6-4 | Fenway Park (13-9) | 30-17 | |
| » W: Cisco Carlos (2-1) L: Vicente Romo (1-4) S: Wilbur Wood (2) | Second | 3½ out |
| Tuesday, June 3 |
| » Defeated White Sox (20-23), 8-2 | Fenway Park (14-9) | 31-17 | |
| » W: Jim Lonborg (5-0) L: Gary Peters (4-6) | Second | 3½ out |
| Wednesday, June 4 |
| » Lost to White Sox (21-23), 7-2 | Fenway Park (14-10) | 31-18 | |
| » W: Tommy John (4-3) L: Sonny Siebert (4-6) | Second | 4½ out |
| Friday, June 6 |
| » Defeated Royals (22-29), 4-2 | Fenway Park (15-10) | 32-18 | |
| » W: Sparky Lyle (5-0) L: Moe Drabowsky (4-5) | Second | 4½ out |
| Saturday, June 7 |
| » Defeated Royals (22-30), 4-0 | Fenway Park (16-10) | 33-18 | Won 2 |
| » W: Mike Nagy (3-0) L: Wally Bunker (2-3) | Second | 4½ out |
| Future Red Sox Jeff Pierce is born in Poughkeepsie, NY. |
| Sunday, June 8 |
| » Defeated Royals (22-31), 8-2 | Fenway Park (17-10) | 34-18 | Won 3 |
| » W: Jim Lonborg (6-0) L: Dick Drago (3-4) | Second | 3½ out |
| Monday, June 9 |
| » Defeated Twins (29-23), 5-3 | Metropolitan Stadium (1-0) | 35-18 | Won 4 |
| » W: Ray Jarvis (3-1) L: Dick Woodson (3-2) S: Vicente Romo (10) | Second | 3 out |
| Tuesday, June 10 |
| » Lost to Twins (30-23), 6-2 | Metropolitan Stadium (1-1) | 35-19 | |
| » W: Jim Kaat (6-4) L: Ray Culp (9-3) | Second | 4 out |
| Wednesday, June 11 |
| » Defeated Twins (30-24), 13-5 | Metropolitan Stadium (2-1) | 36-19 | |
| » W: Sonny Siebert (5-6) L: Dave Boswell (7-7) | Second | 3 out |
| Friday, June 13 |
| » Lost to Athletics (28-25), 4-1 | Fenway Park (17-11) | 36-20 | |
| » W: Chuck Dobson (6-5) L: Jim Lonborg (6-1) S: Rollie Fingers (4) | Second | 4 out |
| Saturday, June 14 |
| » Lost to Athletics (29-25), 21-7 | Fenway Park (17-12) | 36-21 | Lost 2 |
| » W: Blue Moon Odom (8-3) L: Ray Jarvis (3-2) S: Paul Lindblad (3) | Second | 5 out |
| Sunday, June 15 |
| » Lost to Athletics (30-25), 13-5 | Fenway Park (17-13) | 36-22 | Lost 3 |
| » W: Jim Nash (4-3) L: Ray Culp (9-4) S: Lew Krausse (4) | Second | 6½ out |
| Monday, June 16 |
| » Defeated Indians (20-36), 8-5 | Cleveland Stadium (4-0) | 37-22 | |
| » W: Lee Stange (2-4) L: Juan Pizarro (1-2) | Second | 6 out |
| Tuesday, June 17 |
| » Lost to Indians (21-36), 4-2 | Cleveland Stadium (4-1) | 37-23 | |
| » W: Stan Williams (2-6) L: Jim Lonborg (6-2) | Second | 7 out |
| Wednesday, June 18 |
| » Lost to Indians (22-36), 2-1 | Cleveland Stadium (4-2) | 37-24 | Lost 2 |
| » W: Sam McDowell (8-6) L: Ray Jarvis (3-3) | Second | 8 out |
| Thursday, June 19 |
| » Defeated Indians (22-37), 3-0 | Cleveland Stadium (5-2) | 38-24 | |
| » W: Ray Culp (10-4) L: Dick Ellsworth (3-3) | Second | 8 out |
| Saturday, June 21 |
| » Defeated Yankees (32-36), 6-5 | Fenway Park (18-13) | 39-24 | Won 2 |
| » W: Vicente Romo (2-4) L: Ken Johnson (0-2) | Second | 8½ out |
| » Lost to Yankees (33-36), 6-3 | Fenway Park (18-14) | 39-25 | |
| » W: Jack Aker (2-2) L: Sparky Lyle (5-1) | Second | 8½ out |
| Sunday, June 22 |
| » Lost to Yankees (34-36), 5-3 | Fenway Park (18-15) | 39-26 | Lost 2 |
| » W: Jack Aker (3-2) L: Garry Roggenburk (0-1) S: Steve Hamilton (2) | Second | 9 out |
| Tuesday, June 24 |
| » Lost to Indians (25-40), 6-3 | Fenway Park (18-16) | 39-27 | Lost 3 |
| » W: Luis Tiant (5-8) L: Ray Culp (10-5) | Second | 10 out |
| » Defeated Indians (25-41), 6-1 | Fenway Park (19-16) | 40-27 | |
| » W: Lee Stange (3-4) L: Dick Ellsworth (3-4) | Second | 10 out |
| Wednesday, June 25 |
| » Defeated Indians (25-42), 3-1 | Fenway Park (20-16) | 41-27 | Won 2 |
| » W: Sonny Siebert (6-6) L: Steve Hargan (1-5) | Second | 9½ out |
| » Lost to Indians (26-42), 7-3 | Fenway Park (20-17) | 41-28 | |
| » W: Stan Williams (3-7) L: Mike Nagy (3-1) | Second | 9½ out |
| » Major-league debuts: Bill Lee (Red Sox) |
| Thursday, June 26 |
| » Defeated Indians (26-43), 4-3 | Fenway Park (21-17) | 42-28 | |
| » W: Vicente Romo (3-4) L: Larry Burchart (0-1) | Second | 9 out |
| Friday, June 27 |
| » Defeated Senators (35-39), 4-2 | Robert F. Kennedy Stadium (1-2) | 43-28 | Won 2 |
| » W: Bill Landis (4-1) L: Barry Moore (6-3) S: Sparky Lyle (6) | Second | 9 out |
| Saturday, June 28 |
| » Lost to Senators (36-39), 4-3 | Robert F. Kennedy Stadium (1-3) | 43-29 | |
| » W: Darold Knowles (4-1) L: Vicente Romo (3-5) | Second | 10 out |
| Sunday, June 29 |
| » Lost to Senators (37-39), 5-4 | Robert F. Kennedy Stadium (1-4) | 43-30 | Lost 2 |
| » W: Dennis Higgins (6-7) L: Bill Landis (4-2) | Second | 11 out |
| » Lost to Senators (38-39), 11-4 | Robert F. Kennedy Stadium (1-5) | 43-31 | Lost 3 |
| » W: Joe Coleman (4-6) L: Sonny Siebert (6-7) | Second | 11 out |
| Tuesday, July 1 |
| » Lost to Tigers (40-32), 12-4 | Tiger Stadium (2-2) | 43-32 | Lost 4 |
| » W: Pat Dobson (3-5) L: Ray Jarvis (3-4) | Second | 11 out |
| Wednesday, July 2 |
| » Lost to Tigers (41-32), 7-0 | Tiger Stadium (2-3) | 43-33 | Lost 5 |
| » W: Denny McLain (12-5) L: Bill Landis (4-3) | Second | 11 out |
| Thursday, July 3 |
| » Lost to Tigers (42-32), 4-3 | Tiger Stadium (2-4) | 43-34 | Lost 6 |
| » W: Joe Sparma (5-4) L: Ray Culp (10-6) S: Mike Kilkenny (2) | Third | 11½ out |
| Friday, July 4 |
| » Lost to Senators (42-40), 5-1 | Fenway Park (21-18) | 43-35 | Lost 7 |
| » W: Jim Hannan (3-5) L: Lee Stange (3-5) S: Dennis Higgins (12) | Third | 11 out |
| » Defeated Senators (42-41), 7-4 | Fenway Park (22-18) | 44-35 | |
| » W: Mike Nagy (4-1) L: Joe Coleman (4-7) S: Sparky Lyle (7) | Third | 11 out |
| Saturday, July 5 |
| » Lost to Senators (43-41), 6-2 | Fenway Park (22-19) | 44-36 | |
| » W: Barry Moore (7-3) L: Ray Jarvis (3-5) | Third | 11½ out |
| » Defeated Senators (43-42), 11-4 | Fenway Park (23-19) | 45-36 | |
| » W: Sonny Siebert (7-7) L: Jim Shellenback (1-4) | Third | 11½ out |
| Sunday, July 6 |
| » Lost to Senators (44-42), 5-0 | Fenway Park (23-20) | 45-37 | |
| » W: Dick Bosman (6-2) L: Bill Landis (4-4) | Third | 11½ out |
| Monday, July 7 |
| » Defeated Tigers (44-34), 7-2 | Fenway Park (24-20) | 46-37 | |
| » W: Ray Culp (11-6) L: Joe Sparma (5-5) | Third | 11 out |
| Tuesday, July 8 |
| » Defeated Tigers (44-35), 4-1 | Fenway Park (25-20) | 47-37 | Won 2 |
| » W: Mike Nagy (5-1) L: Mickey Lolich (11-2) | Second | 11½ out |
| Former Red Sox Bill Carrigan dies in Lewiston, ME at the age of 86. |
| Wednesday, July 9 |
| » Lost to Tigers (45-35), 6-5 | Fenway Park (25-21) | 47-38 | |
| » W: Pat Dobson (4-6) L: Lee Stange (3-6) S: Don McMahon (7) | Third | 12½ out |
| Thursday, July 10 |
| » Lost to Orioles (60-25), 5-4 | Memorial Stadium (1-2) | 47-39 | Lost 2 |
| » W: Jim Hardin (4-4) L: Vicente Romo (3-6) | Third | 13½ out |
| Friday, July 11 |
| » Defeated Orioles (60-26), 7-4 | Memorial Stadium (2-2) | 48-39 | |
| » W: Ray Culp (12-6) L: Al Severinsen (0-1) S: Sparky Lyle (8) | Second | 11½ out |
| » Defeated Orioles (60-27), 12-3 | Memorial Stadium (3-2) | 49-39 | Won 2 |
| » W: Ray Jarvis (4-5) L: Dave Leonhard (6-2) S: Jim Lonborg (1) | Second | 11½ out |
| Saturday, July 12 |
| » Lost to Orioles (61-27), 4-0 | Memorial Stadium (3-3) | 49-40 | |
| » W: Mike Cuellar (10-7) L: Mike Nagy (5-2) | Third | 12½ out |
| Sunday, July 13 |
| » Lost to Orioles (62-27), 6-3 | Memorial Stadium (3-4) | 49-41 | Lost 2 |
| » W: Dave McNally (13-0) L: Jim Lonborg (6-3) S: Eddie Watt (9) | Third | 13½ out |
| Tuesday, July 15 |
| » Defeated Yankees (42-50), 7-6 | Yankee Stadium (2-1) | 50-41 | |
| » W: Ray Culp (13-6) L: Mel Stottlemyre (13-7) S: Ron Kline (4) | Second | 14 out |
| » Lost to Yankees (43-50), 4-1 | Yankee Stadium (2-2) | 50-42 | |
| » W: Stan Bahnsen (5-10) L: Sonny Siebert (7-8) | Second | 14 out |
| Wednesday, July 16 |
| » Defeated Yankees (43-51), 6-2 | Yankee Stadium (3-2) | 51-42 | |
| » W: Mike Nagy (6-2) L: Bill Burbach (6-8) | Second | 13½ out |
| Friday, July 18 |
| » Defeated Orioles (65-29), 6-1 | Fenway Park (26-21) | 52-42 | Won 2 |
| » W: Ray Jarvis (5-5) L: Dave Leonhard (6-3) | Third | 13 out |
| Saturday, July 19 |
| » Defeated Orioles (65-30), 5-3 | Fenway Park (27-21) | 53-42 | Won 3 |
| » W: Sonny Siebert (8-8) L: Tom Phoebus (9-3) S: Sparky Lyle (9) | Third | 12 out |
| Sunday, July 20 |
| » Defeated Orioles (65-31), 6-5 | Fenway Park (28-21) | 54-42 | Won 4 |
| » W: Ray Culp (14-6) L: Mike Cuellar (10-9) S: Sparky Lyle (10) | Second | 11 out |
| Thursday, July 24 |
| » Lost to Pilots (41-55), 8-6 | Sick's Stadium (2-1) | 54-43 | |
| » W: Gene Brabender (8-7) L: Ray Jarvis (5-6) S: John O'Donoghue (5) | Third | 12 out |
| Friday, July 25 |
| » Defeated Pilots (41-56), 7-6 | Sick's Stadium (3-1) | 55-43 | |
| » W: Bill Landis (5-4) L: John Gelnar (2-8) S: Lee Stange (1) | Third | 12 out |
| Saturday, July 26 |
| » Lost to Pilots (42-56), 8-5 | Sick's Stadium (3-2) | 55-44 | |
| » W: Jim Bouton (2-0) L: Ron Kline (1-6) S: Bob Locker (9) | Third | 13 out |
| Sunday, July 27 |
| » Defeated Pilots (42-57), 5-3 | Sick's Stadium (4-2) | 56-44 | |
| » W: Jim Lonborg (7-3) L: Bob Locker (3-5) | Third | 13 out |
| Tuesday, July 29 |
| » Lost to Angels (39-60), 4-3 | Anaheim Stadium (3-1) | 56-45 | |
| » W: Clyde Wright (1-5) L: Vicente Romo (3-7) | Third | 14 out |
| Wednesday, July 30 |
| » Lost to Angels (40-60), 4-1 | Anaheim Stadium (3-2) | 56-46 | Lost 2 |
| » W: Andy Messersmith (10-7) L: Sonny Siebert (8-9) | Third | 15 out |
| Thursday, July 31 |
| » Defeated Angels (40-61), 9-1 | Anaheim Stadium (4-2) | 57-46 | |
| » W: Ray Culp (15-6) L: Jim McGlothlin (5-11) | Third | 15 out |
| Friday, August 1 |
| » Lost to Athletics (59-41), 4-3 | Oakland-Alameda County Stadium (1-2) | 57-47 | |
| » W: Rollie Fingers (5-5) L: Jim Lonborg (7-4) | Third | 15 out |
| Future Red Sox Brent Knackert is born in Los Angeles, CA. |
| Saturday, August 2 |
| » Lost to Athletics (60-41), 5-4 | Oakland-Alameda County Stadium (1-3) | 57-48 | Lost 2 |
| » W: Marcel Lachemann (3-0) L: Bill Lee (0-1) | Third | 16 out |
| Sunday, August 3 |
| » Lost to Athletics (61-41), 10-7 | Oakland-Alameda County Stadium (1-4) | 57-49 | Lost 3 |
| » W: Paul Lindblad (5-2) L: Bill Landis (5-5) | Third | 15½ out |
| » Defeated Athletics (61-42), 3-2 | Oakland-Alameda County Stadium (2-4) | 58-49 | |
| » W: Sonny Siebert (9-9) L: Catfish Hunter (9-9) S: Sparky Lyle (11) | Third | 15½ out |
| Monday, August 4 |
| Future Red Sox Troy O'Leary is born in Compton, CA. |
| Tuesday, August 5 |
| » Lost to Pilots (44-62), 9-2 | Fenway Park (28-22) | 58-50 | |
| » W: Gene Brabender (9-8) L: Ray Culp (15-7) | Third | 16 out |
| Wednesday, August 6 |
| » Lost to Pilots (45-62), 6-5 | Fenway Park (28-23) | 58-51 | Lost 2 |
| » W: Bob Locker (4-5) L: Vicente Romo (3-8) | Third | 17 out |
| Future Red Sox Keith Mitchell is born in San Diego, CA. |
| Thursday, August 7 |
| » Defeated Pilots (45-63), 5-4 | Fenway Park (29-23) | 59-51 | |
| » W: Lee Stange (4-6) L: Bob Locker (4-6) | Third | 17 out |
| Friday, August 8 |
| » Lost to Angels (42-65), 7-6 | Fenway Park (29-24) | 59-52 | |
| » W: Ken Tatum (5-1) L: Lee Stange (4-7) | Third | 18 out |
| Saturday, August 9 |
| » Defeated Angels (42-66), 9-4 | Fenway Park (30-24) | 60-52 | |
| » W: Ray Culp (16-7) L: Pedro Borbon (2-3) S: Vicente Romo (11) | Third | 18 out |
| Sunday, August 10 |
| » Lost to Angels (43-66), 9-1 | Fenway Park (30-25) | 60-53 | |
| » W: Tom Murphy (7-11) L: Jim Lonborg (7-5) S: Ken Tatum (8) | Third | 19 out |
| Monday, August 11 |
| » Defeated White Sox (43-71), 5-2 | Comiskey Park I (3-1) | 61-53 | |
| » W: Mike Nagy (7-2) L: Paul Edmondson (1-5) S: Sparky Lyle (12) | Third | 18 out |
| Tuesday, August 12 |
| » Lost to White Sox (44-71), 10-5 | Comiskey Park I (3-2) | 61-54 | |
| » W: Dan Osinski (4-5) L: Sonny Siebert (9-10) S: Wilbur Wood (9) | Third | 19 out |
| Wednesday, August 13 |
| » Lost to White Sox (45-71), 5-3 | County Stadium (0-1) | 61-55 | Lost 2 |
| » W: Joe Horlen (8-13) L: Ray Culp (16-8) S: Danny Murphy (1) | Third | 20 out |
| Friday, August 15 |
| » Major-league debuts: Billy Williams (Pilots) |
| Saturday, August 16 |
| » Defeated Royals (47-69), 10-1 | Municipal Stadium (3-1) | 62-55 | |
| » W: Mike Nagy (8-2) L: Bill Butler (6-7) | Third | 21 out |
| » Lost to Royals (48-69), 8-7 | Municipal Stadium (3-2) | 62-56 | |
| » W: Jim Rooker (3-10) L: Jim Lonborg (7-6) S: Galen Cisco (1) | Third | 21 out |
| Sunday, August 17 |
| » Defeated Royals (48-70), 1-0 | Municipal Stadium (4-2) | 63-56 | |
| » W: Vicente Romo (4-8) L: Roger Nelson (6-11) S: Sonny Siebert (1) | Third | 21 out |
| Monday, August 18 |
| » Defeated Twins (71-49), 7-6 | Fenway Park (31-25) | 64-56 | Won 2 |
| » W: Sparky Lyle (6-1) L: Ron Perranoski (8-7) | Third | 21 out |
| Tuesday, August 19 |
| » Lost to Twins (72-49), 8-6 | Fenway Park (31-26) | 64-57 | |
| » W: Dean Chance (4-2) L: Sparky Lyle (6-2) | Third | 22 out |
| Wednesday, August 20 |
| » Defeated Twins (72-50), 7-6 | Fenway Park (32-26) | 65-57 | |
| » W: Sparky Lyle (7-2) L: Ron Perranoski (8-8) | Third | 21 out |
| Friday, August 22 |
| » Lost to White Sox (47-76), 4-1 | Fenway Park (32-27) | 65-58 | |
| » W: Gary Peters (8-12) L: Vicente Romo (4-9) | Third | 21½ out |
| Future Red Sox Hipolito Pichardo is born in Jicome Esperanza, D.R. |
| Saturday, August 23 |
| » Defeated White Sox (47-77), 2-0 | Fenway Park (33-27) | 66-58 | |
| » W: Ray Culp (17-8) L: Billy Wynne (4-4) | Third | 20½ out |
| Sunday, August 24 |
| » Lost to White Sox (48-77), 3-1 | Fenway Park (33-28) | 66-59 | |
| » W: Joe Horlen (9-14) L: Jim Lonborg (7-7) S: Wilbur Wood (10) | Third | 20 out |
| Tuesday, August 26 |
| » Defeated Royals (51-74), 4-1 | Fenway Park (34-28) | 67-59 | |
| » W: Mike Nagy (9-2) L: Bill Butler (7-8) | Third | 19 out |
| Future Red Sox Ken Grundt is born in Melrose Park, IL. |
| Wednesday, August 27 |
| » Defeated Royals (51-75), 4-3 | Fenway Park (35-28) | 68-59 | Won 2 |
| » W: Vicente Romo (5-9) L: Jim Rooker (4-11) | Third | 19 out |
| Thursday, August 28 |
| » Defeated Royals (51-76), 9-8 | Fenway Park (36-28) | 69-59 | Won 3 |
| » W: Sparky Lyle (8-2) L: Moe Drabowsky (7-7) | Third | 19 out |
| Friday, August 29 |
| » Lost to Twins (78-51), 10-4 | Metropolitan Stadium (2-2) | 69-60 | |
| » W: Tom Hall (7-4) L: Jim Lonborg (7-8) | Third | 18½ out |
| Saturday, August 30 |
| » Defeated Twins (78-52), 7-5 | Metropolitan Stadium (3-2) | 70-60 | |
| » W: Mike Nagy (10-2) L: Dave Boswell (14-10) S: Sparky Lyle (13) | Third | 18½ out |
| Sunday, August 31 |
| » Lost to Twins (79-52), 6-2 | Metropolitan Stadium (3-3) | 70-61 | |
| » W: Jim Perry (17-5) L: Vicente Romo (5-10) S: Ron Perranoski (25) | Third | 19½ out |
| Future Red Sox Nate Minchey is born in Austin, TX. |
| Monday, September 1 |
| » Defeated Athletics (74-57), 6-2 | Fenway Park (37-28) | 71-61 | |
| » W: Lee Stange (5-7) L: Chuck Dobson (14-11) S: Sonny Siebert (2) | Third | 19½ out |
| » Major-league debuts: Bobby Brooks (Athletics) |
| Wednesday, September 3 |
| » Lost to Athletics (75-57), 7-4 | Fenway Park (37-29) | 71-62 | |
| » W: Jim Roland (2-1) L: Sonny Siebert (9-11) S: Paul Lindblad (8) | Third | 19 out |
| » Defeated Athletics (75-58), 5-1 | Fenway Park (38-29) | 72-62 | |
| » W: Mike Nagy (11-2) L: George Lauzerique (3-3) | Third | 19 out |
| Thursday, September 4 |
| » Major-league debuts: Terry Crowley (Orioles) |
| Friday, September 5 |
| » Defeated Senators (71-67), 9-8 | Fenway Park (39-29) | 73-62 | Won 2 |
| » W: Sonny Siebert (10-11) L: Bob Humphreys (2-3) | Third | 19½ out |
| » Major-league debuts: Toby Harrah (Senators) |
| Saturday, September 6 |
| » Defeated Senators (71-68), 9-5 | Fenway Park (40-29) | 74-62 | Won 3 |
| » W: Lee Stange (6-7) L: Joe Coleman (10-12) S: Sonny Siebert (3) | Third | 18½ out |
| Sunday, September 7 |
| » Lost to Senators (72-68), 3-2 | Fenway Park (40-30) | 74-63 | |
| » W: Casey Cox (11-5) L: Jim Lonborg (7-9) S: Darold Knowles (11) | Third | 19½ out |
| Future Red Sox Darren Bragg is born in Waterbury, CT. |
| Monday, September 8 |
| » Defeated Indians (56-85), 5-4 | Cleveland Stadium (6-2) | 75-63 | |
| » W: Sonny Siebert (11-11) L: Phil Hennigan (0-1) | Third | 19 out |
| Tuesday, September 9 |
| » Defeated Indians (56-86), 3-1 | Cleveland Stadium (7-2) | 76-63 | Won 2 |
| » W: Vicente Romo (6-10) L: Sam McDowell (16-13) | Third | 19½ out |
| Wednesday, September 10 |
| » Lost to Orioles (98-45), 8-7 | Memorial Stadium (3-5) | 76-64 | |
| » W: Al Severinsen (1-1) L: Gary Wagner (0-4) S: Eddie Watt (15) | Third | 20½ out |
| Thursday, September 11 |
| » Lost to Orioles (99-45), 4-2 | Memorial Stadium (3-6) | 76-65 | Lost 2 |
| » W: Dave McNally (18-6) L: Lee Stange (6-8) | Third | 21½ out |
| Friday, September 12 |
| » Lost to Yankees (71-72), 5-3 | Yankee Stadium (3-3) | 76-66 | Lost 3 |
| » W: Al Downing (6-4) L: Jim Lonborg (7-10) | Third | 22 out |
| » Defeated Yankees (71-73), 4-3 | Yankee Stadium (4-3) | 77-66 | |
| » W: Ken Brett (1-1) L: Mike Kekich (2-5) S: Sonny Siebert (4) | Third | 22 out |
| Saturday, September 13 |
| » Defeated Yankees (71-74), 5-2 | Yankee Stadium (5-3) | 78-66 | Won 2 |
| » W: Gary Wagner (1-4) L: Fritz Peterson (15-15) S: Sparky Lyle (14) | Third | 22 out |
| Sunday, September 14 |
| » Lost to Yankees (72-74), 3-2 | Yankee Stadium (5-4) | 78-67 | |
| » W: Jack Aker (8-5) L: Sparky Lyle (8-3) | Third | 23 out |
| » Major-league debuts: |