| Monday, April 7 |
| » Major-league debuts: Bob Didier (Braves) |
| Tuesday, April 8 |
| » Defeated Angels (0-1), 4-3 | Anaheim Stadium (1-0) | 1-0 | |
| » W: Marty Pattin (1-0) L: Jim McGlothlin (0-1) S: Jack Aker (1) | First | -- |
| Wednesday, April 9 |
| » Lost to Angels (1-1), 7-3 | Anaheim Stadium (1-1) | 1-1 | |
| » W: Pedro Borbon (1-0) L: Gene Brabender (0-1) S: Hoyt Wilhelm (1) | Second | 1 out |
| » Major-league debuts: Pedro Borbon (Angels) |
| Friday, April 11 |
| » Defeated White Sox (1-2), 7-0 | Sick's Stadium (1-0) | 2-1 | |
| » W: Gary Bell (1-0) L: Joe Horlen (0-1) | First | -- |
| Saturday, April 12 |
| » Defeated White Sox (1-3), 5-1 | Sick's Stadium (2-0) | 3-1 | Won 2 |
| » W: Diego Segui (1-0) L: Sammy Ellis (0-1) S: Jack Aker (2) | First | -- |
| Sunday, April 13 |
| » Lost to White Sox (2-3), 12-7 | Sick's Stadium (2-1) | 3-2 | |
| » W: Wilbur Wood (1-0) L: Marty Pattin (1-1) | Second | ½ out |
| Monday, April 14 |
| » Lost to Royals (5-2), 2-1 | Sick's Stadium (2-2) | 3-3 | Lost 2 |
| » W: Roger Nelson (1-0) L: Mike Marshall (0-1) S: Dave Wickersham (2) | Second | 1½ out |
| Tuesday, April 15 |
| » Major-league debuts: Ray Jarvis and Syd O'Brien (Red Sox) |
| Wednesday, April 16 |
| » Lost to Twins (3-4), 6-4 | Sick's Stadium (2-3) | 3-4 | Lost 3 |
| » W: Ron Perranoski (2-0) L: Jack Aker (0-1) | Fourth | 1½ out |
| Saturday, April 19 |
| » Defeated White Sox (4-4), 5-1 | Comiskey Park I (1-0) | 4-4 | |
| » W: Marty Pattin (2-1) L: Gary Peters (0-2) S: Diego Segui (1) | Second | ½ out |
| Sunday, April 20 |
| » Lost to White Sox (5-4), 3-2 | Comiskey Park I (1-1) | 4-5 | |
| » W: Wilbur Wood (2-0) L: Diego Segui (1-1) | Third | 2 out |
| » Lost to White Sox (6-4), 13-3 | Comiskey Park I (1-2) | 4-6 | Lost 2 |
| » W: Joe Horlen (2-1) L: Steve Barber (0-1) S: Bob Locker (2) | Third | 2 out |
| Monday, April 21 |
| » Defeated Royals (6-6), 4-1 | Municipal Stadium (1-0) | 5-6 | |
| » W: Mike Marshall (1-1) L: Steve Jones (1-1) S: Jack Aker (3) | Fourth | 2 out |
| Tuesday, April 22 |
| » Lost to Royals (7-6), 2-1 | Municipal Stadium (1-1) | 5-7 | |
| » W: Mike Hedlund (1-0) L: Diego Segui (1-2) S: Moe Drabowsky (2) | Fourth | 2 out |
| Wednesday, April 23 |
| » Lost to Royals (8-6), 4-3 | Municipal Stadium (1-2) | 5-8 | Lost 2 |
| » W: Dave Morehead (1-2) L: Bill Edgerton (0-1) | Fifth | 3 out |
| Friday, April 25 |
| » Lost to Athletics (9-7), 14-2 | Sick's Stadium (2-4) | 5-9 | Lost 3 |
| » W: Jim Nash (3-1) L: Gary Bell (1-1) | Fifth | 3½ out |
| Saturday, April 26 |
| » Defeated Athletics (9-8), 6-3 | Sick's Stadium (3-4) | 6-9 | |
| » W: Steve Barber (1-1) L: Chuck Dobson (1-3) S: Diego Segui (2) | Fifth | 2½ out |
| Sunday, April 27 |
| » Lost to Athletics (10-8), 13-5 | Sick's Stadium (3-5) | 6-10 | |
| » W: Rollie Fingers (2-0) L: Mike Marshall (1-2) S: Lew Krausse (3) | Sixth | 3½ out |
| Tuesday, April 29 |
| » Defeated Angels (6-9), 1-0 | Sick's Stadium (4-5) | 7-10 | |
| » W: Marty Pattin (3-1) L: Jim McGlothlin (1-2) | Fifth | 4 out |
| Wednesday, April 30 |
| » Lost to Twins (13-7), 6-4 | Metropolitan Stadium (0-1) | 7-11 | |
| » W: Tom Hall (2-1) L: Gene Brabender (0-2) S: Ron Perranoski (3) | Fifth | 5 out |
| Thursday, May 1 |
| » Lost to Twins (14-7), 4-1 | Metropolitan Stadium (0-2) | 7-12 | Lost 2 |
| » W: Dave Boswell (3-2) L: Gary Bell (1-2) S: Joe Grzenda (2) | Sixth | 6 out |
| Friday, May 2 |
| » Lost to Athletics (12-9), 8-7 | Oakland-Alameda County Stadium (0-1) | 7-13 | Lost 3 |
| » W: Paul Lindblad (1-0) L: Jack Aker (0-2) | Sixth | 6½ out |
| Saturday, May 3 |
| » Lost to Athletics (13-9), 3-2 | Oakland-Alameda County Stadium (0-2) | 7-14 | Lost 4 |
| » W: Chuck Dobson (2-3) L: Mike Marshall (1-3) | Sixth | 7½ out |
| Sunday, May 4 |
| » Defeated Athletics (13-10), 6-4 | Oakland-Alameda County Stadium (1-2) | 8-14 | |
| » W: Marty Pattin (4-1) L: Rollie Fingers (2-1) S: John O'Donoghue (1) | Sixth | 8 out |
| » Lost to Athletics (14-10), 11-7 | Oakland-Alameda County Stadium (1-3) | 8-15 | |
| » W: Blue Moon Odom (5-1) L: Bucky Brandon (0-1) S: Paul Lindblad (1) | Sixth | 8 out |
| Tuesday, May 6 |
| » Lost to Red Sox (15-10), 12-2 | Sick's Stadium (4-6) | 8-16 | Lost 2 |
| » W: Ray Culp (5-1) L: Gene Brabender (0-3) | Sixth | 8 out |
| Wednesday, May 7 |
| » Lost to Red Sox (16-10), 5-4 | Sick's Stadium (4-7) | 8-17 | Lost 3 |
| » W: Sonny Siebert (2-3) L: Gary Bell (1-3) S: Vicente Romo (2) | Sixth | 9 out |
| Friday, May 9 |
| » Defeated Senators (16-14), 2-0 | Sick's Stadium (5-7) | 9-17 | |
| » W: Mike Marshall (2-3) L: Joe Coleman (2-3) | Sixth | 9 out |
| Saturday, May 10 |
| » Defeated Senators (16-15), 16-13 | Sick's Stadium (6-7) | 10-17 | Won 2 |
| » W: Diego Segui (2-2) L: Dennis Higgins (1-3) S: Gary Bell (1) | Fifth | 8½ out |
| Sunday, May 11 |
| » Defeated Senators (16-16), 6-5 | Sick's Stadium (7-7) | 11-17 | Won 3 |
| » W: Diego Segui (3-2) L: Dave Baldwin (1-1) | Fifth | 7½ out |
| Monday, May 12 |
| » Defeated Yankees (12-20), 8-4 | Sick's Stadium (8-7) | 12-17 | Won 4 |
| » W: Marty Pattin (5-1) L: Al Downing (0-1) | Fifth | 7 out |
| Tuesday, May 13 |
| » Defeated Yankees (12-21), 5-3 | Sick's Stadium (9-7) | 13-17 | Won 5 |
| » W: Gary Bell (2-3) L: Mel Stottlemyre (5-3) S: Diego Segui (3) | Fifth | 7 out |
| Wednesday, May 14 |
| » Lost to Yankees (13-21), 5-4 | Sick's Stadium (9-8) | 13-18 | |
| » W: Bill Burbach (2-3) L: Mike Marshall (2-4) S: Stan Bahnsen (1) | Fifth | 7 out |
| Friday, May 16 |
| » Defeated Red Sox (20-12), 10-9 | Fenway Park (1-0) | 14-18 | |
| » W: Jim Bouton (1-0) L: Vicente Romo (1-3) S: John O'Donoghue (2) | Fifth | 7 out |
| Saturday, May 17 |
| » Lost to Red Sox (21-12), 6-1 | Fenway Park (1-1) | 14-19 | |
| » W: Mike Nagy (2-0) L: Gary Bell (2-4) | Fifth | 7 out |
| Sunday, May 18 |
| » Defeated Red Sox (21-13), 9-6 | Fenway Park (2-1) | 15-19 | |
| » W: Mike Marshall (3-4) L: Ray Culp (6-2) S: Diego Segui (4) | Fifth | 6½ out |
| Tuesday, May 20 |
| » Lost to Senators (20-20), 6-5 | Robert F. Kennedy Stadium (0-1) | 15-20 | |
| » W: Dennis Higgins (3-3) L: Marty Pattin (5-2) | Fifth | 6½ out |
| Wednesday, May 21 |
| » Defeated Senators (20-21), 6-2 | Robert F. Kennedy Stadium (1-1) | 16-20 | |
| » W: Gene Brabender (1-3) L: Joe Coleman (2-4) S: Diego Segui (5) | Fifth | 5½ out |
| Thursday, May 22 |
| » Defeated Senators (20-22), 7-6 | Robert F. Kennedy Stadium (2-1) | 17-20 | Won 2 |
| » W: Diego Segui (4-2) L: Dennis Higgins (3-4) | Fourth | 5 out |
| Friday, May 23 |
| » Lost to Indians (10-24), 7-1 | Cleveland Stadium (0-1) | 17-21 | |
| » W: Dick Ellsworth (2-1) L: Mike Marshall (3-5) | Fifth | 5 out |
| Saturday, May 24 |
| » Defeated Indians (10-25), 8-2 | Cleveland Stadium (1-1) | 18-21 | |
| » W: Fred Talbot (1-0) L: Sam McDowell (3-5) | Fourth | 4 out |
| Sunday, May 25 |
| » Defeated Indians (10-26), 3-2 | Cleveland Stadium (2-1) | 19-21 | Won 2 |
| » W: Diego Segui (5-2) L: Stan Williams (1-5) S: Gary Bell (2) | Fifth | 4½ out |
| Tuesday, May 27 |
| » Defeated Orioles (32-14), 8-1 | Sick's Stadium (10-8) | 20-21 | Won 3 |
| » W: Gene Brabender (2-3) L: Tom Phoebus (5-1) | Fourth | 4 out |
| Wednesday, May 28 |
| » Lost to Orioles (33-14), 9-5 | Sick's Stadium (10-9) | 20-22 | |
| » W: Dave McNally (7-0) L: Mike Marshall (3-6) S: Pete Richert (5) | Fifth | 4 out |
| Friday, May 30 |
| » Lost to Tigers (24-18), 8-5 | Sick's Stadium (10-10) | 20-23 | Lost 2 |
| » W: Dick Radatz (2-2) L: Marty Pattin (5-3) S: Pat Dobson (7) | Fourth | 4 out |
| Saturday, May 31 |
| » Lost to Tigers (25-18), 3-2 | Sick's Stadium (10-11) | 20-24 | Lost 3 |
| » W: Joe Sparma (3-1) L: Gary Bell (2-5) | Fifth | 5 out |
| Sunday, June 1 |
| » Defeated Tigers (25-19), 8-7 | Sick's Stadium (11-11) | 21-24 | |
| » W: Diego Segui (6-2) L: Pat Dobson (1-3) S: John O'Donoghue (3) | Third | 4 out |
| Monday, June 2 |
| » Defeated Indians (12-31), 8-2 | Sick's Stadium (12-11) | 22-24 | Won 2 |
| » W: Steve Barber (2-1) L: Horacio Pina (2-1) S: Jim Bouton (1) | Third | 4 out |
| Tuesday, June 3 |
| » Lost to Indians (13-31), 3-1 | Sick's Stadium (12-12) | 22-25 | |
| » W: Luis Tiant (2-7) L: Marty Pattin (5-4) S: Stan Williams (2) | Third | 5 out |
| Wednesday, June 4 |
| » Lost to Indians (14-31), 10-4 | Sick's Stadium (12-13) | 22-26 | Lost 2 |
| » W: Sam McDowell (5-6) L: Mike Marshall (3-7) S: Stan Williams (3) | Fourth | 6 out |
| Friday, June 6 |
| » Lost to Orioles (38-15), 5-1 | Memorial Stadium (0-1) | 22-27 | Lost 3 |
| » W: Dave McNally (8-0) L: Gary Bell (2-6) | Fourth | 6 out |
| Saturday, June 7 |
| » Lost to Orioles (39-15), 10-0 | Memorial Stadium (0-2) | 22-28 | Lost 4 |
| » W: Jim Palmer (7-2) L: Gene Brabender (2-4) | Fourth | 7 out |
| Sunday, June 8 |
| » Defeated Orioles (39-16), 7-5 | Memorial Stadium (1-2) | 23-28 | |
| » W: John O'Donoghue (1-0) L: Mike Cuellar (6-5) | Third | 6 out |
| Monday, June 9 |
| » Defeated Tigers (27-23), 3-2 | Tiger Stadium (1-0) | 24-28 | Won 2 |
| » W: Marty Pattin (6-4) L: Pat Dobson (1-4) S: John Gelnar (1) | Third | 5 out |
| Tuesday, June 10 |
| » Lost to Tigers (28-23), 5-0 | Tiger Stadium (1-1) | 24-29 | |
| » W: Earl Wilson (5-5) L: Fred Talbot (1-1) S: Don McMahon (5) | Third | 6 out |
| Wednesday, June 11 |
| » Lost to Tigers (29-23), 4-3 | Tiger Stadium (1-2) | 24-30 | Lost 2 |
| » W: Pat Dobson (2-4) L: John O'Donoghue (1-1) | Fourth | 6 out |
| Friday, June 13 |
| » Defeated Yankees (29-31), 2-1 | Yankee Stadium (1-0) | 25-30 | |
| » W: Gene Brabender (3-4) L: Mel Stottlemyre (9-5) | Third | 5 out |
| Saturday, June 14 |
| » Defeated Yankees (29-32), 5-4 | Yankee Stadium (2-0) | 26-30 | Won 2 |
| » W: John Gelnar (1-0) L: Lindy McDaniel (3-3) S: Diego Segui (6) | Third | 4 out |
| Sunday, June 15 |
| » Lost to Yankees (30-32), 4-0 | Yankee Stadium (2-1) | 26-31 | |
| » W: Stan Bahnsen (3-9) L: Fred Talbot (1-2) | Third | 5 out |
| Monday, June 16 |
| » Lost to White Sox (24-32), 8-3 | County Stadium (0-1) | 26-32 | Lost 2 |
| » W: Billy Wynne (1-0) L: Mike Marshall (3-8) | Third | 6 out |
| Wednesday, June 18 |
| » Lost to White Sox (25-32), 7-3 | Comiskey Park I (1-3) | 26-33 | Lost 3 |
| » W: Gary Peters (5-8) L: Gene Brabender (3-5) | Third | 6½ out |
| » Defeated White Sox (25-33), 6-5 | Comiskey Park I (2-3) | 27-33 | |
| » W: Bob Locker (3-3) L: Dan Osinski (2-1) | Third | 6½ out |
| Thursday, June 19 |
| » Lost to White Sox (26-33), 13-10 | Comiskey Park I (2-4) | 27-34 | |
| » W: Wilbur Wood (3-2) L: Mike Marshall (3-9) | Third | 7 out |
| Friday, June 20 |
| » Defeated Royals (25-38), 5-3 | Sick's Stadium (13-13) | 28-34 | |
| » W: Fred Talbot (2-2) L: Bill Butler (2-3) S: Bob Locker (5) | Third | 7½ out |
| » Lost to Royals (26-38), 6-2 | Sick's Stadium (13-14) | 28-35 | |
| » W: Wally Bunker (3-3) L: John Gelnar (1-1) | Third | 7½ out |
| Saturday, June 21 |
| » Defeated Royals (26-39), 1-0 | Sick's Stadium (14-14) | 29-35 | |
| » W: Gene Brabender (4-5) L: Roger Nelson (4-6) | Third | 6½ out |
| Sunday, June 22 |
| » Defeated Royals (26-40), 5-1 | Sick's Stadium (15-14) | 30-35 | Won 2 |
| » W: Marty Pattin (7-4) L: Dick Drago (3-7) S: Bob Locker (6) | Third | 6 out |
| Tuesday, June 24 |
| » Lost to White Sox (29-35), 6-4 | Sick's Stadium (15-15) | 30-36 | |
| » W: Wilbur Wood (4-2) L: Bob Locker (3-4) | Fourth | 7 out |
| » Lost to White Sox (30-35), 7-6 | Sick's Stadium (15-16) | 30-37 | Lost 2 |
| » W: Wilbur Wood (5-2) L: Diego Segui (6-3) | Fourth | 7 out |
| Wednesday, June 25 |
| » Defeated White Sox (30-36), 3-1 | Sick's Stadium (16-16) | 31-37 | |
| » W: John Gelnar (2-1) L: Paul Edmondson (1-1) S: Bob Locker (7) | Third | 7 out |
| Thursday, June 26 |
| » Defeated White Sox (30-37), 3-2 | Sick's Stadium (17-16) | 32-37 | Won 2 |
| » W: Gene Brabender (5-5) L: Joe Horlen (4-8) | Third | 7 out |
| » Major-league debuts: Steve Hovley (Pilots) |
| Friday, June 27 |
| » Lost to Angels (24-44), 5-3 | Anaheim Stadium (1-2) | 32-38 | |
| » W: Eddie Fisher (1-2) L: Marty Pattin (7-5) | Third | 7 out |
| » Defeated Angels (24-45), 5-2 | Anaheim Stadium (2-2) | 33-38 | |
| » W: Garry Roggenburk (1-1) L: Greg Washburn (0-2) S: Bob Locker (8) | Third | 7 out |
| Saturday, June 28 |
| » Defeated Angels (24-46), 3-0 | Anaheim Stadium (3-2) | 34-38 | Won 2 |
| » W: Fred Talbot (3-2) L: Tom Murphy (4-6) S: Diego Segui (7) | Third | 6 out |
| Sunday, June 29 |
| » Lost to Angels (25-46), 8-2 | Anaheim Stadium (3-3) | 34-39 | |
| » W: Andy Messersmith (4-6) L: John Gelnar (2-2) S: Ken Tatum (3) | Third | 7½ out |
| Tuesday, July 1 |
| » Defeated Athletics (40-31), 7-1 | Oakland-Alameda County Stadium (2-3) | 35-39 | |
| » W: Gene Brabender (6-5) L: Chuck Dobson (9-6) | Third | 6½ out |
| Wednesday, July 2 |
| » Lost to Athletics (41-31), 5-0 | Oakland-Alameda County Stadium (2-4) | 35-40 | |
| » W: Blue Moon Odom (11-3) L: Marty Pattin (7-6) | Third | 7½ out |
| Thursday, July 3 |
| » Lost to Athletics (42-31), 6-4 | Oakland-Alameda County Stadium (2-5) | 35-41 | Lost 2 |
| » W: Lew Krausse (2-3) L: Garry Roggenburk (1-2) S: Rollie Fingers (7) | Third | 8½ out |
| Friday, July 4 |
| » Lost to Royals (33-45), 13-2 | Municipal Stadium (1-3) | 35-42 | Lost 3 |
| » W: Roger Nelson (5-7) L: Fred Talbot (3-3) | Third | 9 out |
| » Lost to Royals (34-45), 3-2 | Municipal Stadium (1-4) | 35-43 | Lost 4 |
| » W: Dick Drago (4-7) L: John Gelnar (2-3) S: Don O'Riley (1) | Third | 9 out |
| Saturday, July 5 |
| » Lost to Royals (35-45), 6-4 | Municipal Stadium (1-5) | 35-44 | Lost 5 |
| » W: Tom Burgmeier (3-0) L: Mike Marshall (3-10) S: Moe Drabowsky (8) | Third | 10 out |
| Sunday, July 6 |
| » Defeated Royals (35-46), 9-3 | Municipal Stadium (2-5) | 36-44 | |
| » W: Gene Brabender (7-5) L: Bill Butler (4-4) S: Diego Segui (8) | Third | 10 out |
| Monday, July 7 |
| » Lost to Angels (30-50), 5-1 | Sick's Stadium (17-17) | 36-45 | |
| » W: Andy Messersmith (6-6) L: Marty Pattin (7-7) | Third | 11 out |
| Tuesday, July 8 |
| » Defeated Angels (30-51), 3-1 | Sick's Stadium (18-17) | 37-45 | |
| » W: Garry Roggenburk (2-2) L: Jim McGlothlin (5-8) | Third | 11 out |
| Wednesday, July 9 |
| » Defeated Angels (30-52), 8-0 | Sick's Stadium (19-17) | 38-45 | Won 2 |
| » W: Fred Talbot (4-3) L: Clyde Wright (0-4) | Third | 10½ out |
| » Lost to Angels (31-52), 5-0 | Sick's Stadium (19-18) | 38-46 | |
| » W: George Brunet (5-6) L: John Gelnar (2-4) | Third | 10½ out |
| Friday, July 11 |
| » Lost to Twins (50-35), 9-3 | Metropolitan Stadium (0-3) | 38-47 | Lost 2 |
| » W: Tom Hall (4-4) L: Gene Brabender (7-6) | Third | 12 out |
| » Major-league debuts: Dick Baney (Pilots) |
| Saturday, July 12 |
| » Lost to Twins (51-35), 11-1 | Metropolitan Stadium (0-4) | 38-48 | Lost 3 |
| » W: Jim Perry (8-4) L: Marty Pattin (7-8) | Third | 13 out |
| Sunday, July 13 |
| » Lost to Twins (52-35), 5-2 | Metropolitan Stadium (0-5) | 38-49 | Lost 4 |
| » W: Jim Kaat (9-6) L: Garry Roggenburk (2-3) | Fourth | 15 out |
| » Lost to Twins (53-35), 5-4 | Metropolitan Stadium (0-6) | 38-50 | Lost 5 |
| » W: Ron Perranoski (5-4) L: Diego Segui (6-4) | Fourth | 15 out |
| Tuesday, July 15 |
| » Lost to Athletics (48-38), 6-2 | Sick's Stadium (19-19) | 38-51 | Lost 6 |
| » W: Blue Moon Odom (13-3) L: John Gelnar (2-5) | Fourth | 16 out |
| Wednesday, July 16 |
| » Lost to Athletics (49-38), 6-1 | Sick's Stadium (19-20) | 38-52 | Lost 7 |
| » W: Lew Krausse (4-4) L: Gene Brabender (7-7) | Fourth | 17½ out |
| Thursday, July 17 |
| » Lost to Athletics (50-38), 8-2 | Sick's Stadium (19-21) | 38-53 | Lost 8 |
| » W: Catfish Hunter (8-7) L: Marty Pattin (7-9) | Fourth | 18½ out |
| Friday, July 18 |
| » Defeated Twins (57-36), 2-1 | Sick's Stadium (20-21) | 39-53 | |
| » W: Diego Segui (7-4) L: Ron Perranoski (5-5) | Third | 16½ out |
| » Defeated Twins (57-37), 3-2 | Sick's Stadium (21-21) | 40-53 | Won 2 |
| » W: Fred Talbot (5-3) L: Dave Boswell (11-9) S: John O'Donoghue (4) | Third | 16½ out |
| Saturday, July 19 |
| » Lost to Twins (58-37), 11-7 | Sick's Stadium (21-22) | 40-54 | |
| » W: Jim Perry (10-4) L: John Gelnar (2-6) | Third | 16½ out |
| Sunday, July 20 |
| » Lost to Twins (59-37), 4-0 | Sick's Stadium (21-23) | 40-55 | Lost 2 |
| » W: Jim Perry (11-4) L: John Gelnar (2-7) | Fourth | 18½ out |
| Thursday, July 24 |
| » Defeated Red Sox (54-43), 8-6 | Sick's Stadium (22-23) | 41-55 | |
| » W: Gene Brabender (8-7) L: Ray Jarvis (5-6) S: John O'Donoghue (5) | Third | 17½ out |
| Friday, July 25 |
| » Lost to Red Sox (55-43), 7-6 | Sick's Stadium (22-24) | 41-56 | |
| » W: Bill Landis (5-4) L: John Gelnar (2-8) S: Lee Stange (1) | Third | 18½ out |
| Saturday, July 26 |
| » Defeated Red Sox (55-44), 8-5 | Sick's Stadium (23-24) | 42-56 | |
| » W: Jim Bouton (2-0) L: Ron Kline (1-6) S: Bob Locker (9) | Third | 17½ out |
| Sunday, July 27 |
| » Lost to Red Sox (56-44), 5-3 | Sick's Stadium (23-25) | 42-57 | |
| » W: Jim Lonborg (7-3) L: Bob Locker (3-5) | Third | 18½ out |
| Tuesday, July 29 |
| » Lost to Senators (53-53), 4-2 | Sick's Stadium (23-26) | 42-58 | Lost 2 |
| » W: Joe Coleman (8-8) L: Gene Brabender (8-8) | Third | 20 out |
| Wednesday, July 30 |
| » Defeated Senators (53-54), 4-3 | Sick's Stadium (24-26) | 43-58 | |
| » W: Diego Segui (8-4) L: Casey Cox (7-4) S: John Gelnar (2) | Third | 19 out |
| Thursday, July 31 |
| » Lost to Senators (54-54), 7-6 | Sick's Stadium (24-27) | 43-59 | |
| » W: Jim Shellenback (4-5) L: Fred Talbot (5-4) S: Darold Knowles (6) | Third | 20 out |
| Friday, August 1 |
| » Lost to Yankees (50-56), 4-2 | Sick's Stadium (24-28) | 43-60 | Lost 2 |
| » W: Ken Johnson (1-3) L: Marty Pattin (7-10) | Third | 21 out |
| Saturday, August 2 |
| » Lost to Yankees (51-56), 5-4 | Sick's Stadium (24-29) | 43-61 | Lost 3 |
| » W: Al Downing (2-3) L: George Brunet (6-8) S: Jack Aker (9) | Third | 21 out |
| Sunday, August 3 |
| » Lost to Yankees (52-56), 5-3 | Sick's Stadium (24-30) | 43-62 | Lost 4 |
| » W: Stan Bahnsen (7-11) L: Steve Barber (2-2) S: Lindy McDaniel (2) | Fourth | 22 out |
| Tuesday, August 5 |
| » Defeated Red Sox (58-50), 9-2 | Fenway Park (3-1) | 44-62 | |
| » W: Gene Brabender (9-8) L: Ray Culp (15-7) | Third | 21½ out |
| Wednesday, August 6 |
| » Defeated Red Sox (58-51), 6-5 | Fenway Park (4-1) | 45-62 | Won 2 |
| » W: Bob Locker (4-5) L: Vicente Romo (3-8) | Third | 21½ out |
| Thursday, August 7 |
| » Lost to Red Sox (59-51), 5-4 | Fenway Park (4-2) | 45-63 | |
| » W: Lee Stange (4-6) L: Bob Locker (4-6) | Third | 21½ out |
| Friday, August 8 |
| » Lost to Senators (58-56), 10-3 | Robert F. Kennedy Stadium (2-2) | 45-64 | Lost 2 |
| » W: Joe Coleman (9-8) L: George Brunet (6-9) S: Dave Baldwin (4) | Third | 21½ out |
| Saturday, August 9 |
| » Defeated Senators (58-57), 8-6 | Robert F. Kennedy Stadium (3-2) | 46-64 | |
| » W: Bob Locker (5-6) L: Dave Baldwin (2-3) | Third | 20½ out |
| Sunday, August 10 |
| » Lost to Senators (59-57), 7-5 | Robert F. Kennedy Stadium (3-3) | 46-65 | |
| » W: Darold Knowles (5-2) L: John Gelnar (2-9) S: Joe Coleman (1) | Third | 20½ out |
| Monday, August 11 |
| » Defeated Indians (48-69), 8-2 | Cleveland Stadium (3-1) | 47-65 | |
| » W: Diego Segui (9-4) L: Luis Tiant (8-14) | Third | 20 out |
| Tuesday, August 12 |
| » Lost to Indians (49-69), 6-5 | Cleveland Stadium (3-2) | 47-66 | |
| » W: Mike Paul (5-8) L: Fred Talbot (5-5) S: Stan Williams (10) | Third | 20 out |
| Wednesday, August 13 |
| » Defeated Indians (49-70), 5-3 | Cleveland Stadium (4-2) | 48-66 | |
| » W: George Brunet (7-9) L: Steve Hargan (4-10) | Third | 20 out |
| Friday, August 15 |
| » Lost to Orioles (82-35), 2-1 | Sick's Stadium (24-31) | 48-67 | |
| » W: Mike Cuellar (16-9) L: Gene Brabender (9-9) | Third | 21 out |
| » Major-league debuts: Billy Williams (Pilots) |
| Saturday, August 16 |
| » Lost to Orioles (83-35), 15-3 | Sick's Stadium (24-32) | 48-68 | Lost 2 |
| » W: Dave McNally (17-2) L: Diego Segui (9-5) S: Jim Hardin (1) | Third | 21 out |
| Sunday, August 17 |
| » Lost to Orioles (84-35), 4-1 | Sick's Stadium (24-33) | 48-69 | Lost 3 |
| » W: Tom Phoebus (12-4) L: Fred Talbot (5-6) S: Eddie Watt (12) | Third | 22 out |
| Monday, August 18 |
| » Lost to Orioles (85-35), 12-3 | Sick's Stadium (24-34) | 48-70 | Lost 4 |
| » W: Jim Palmer (12-2) L: George Brunet (7-10) | Fourth | 22 out |
| Tuesday, August 19 |
| » Lost to Tigers (68-51), 5-3 | Sick's Stadium (24-35) | 48-71 | Lost 5 |
| » W: Mike Kilkenny (3-3) L: Steve Barber (2-3) S: Pat Dobson (9) | Fourth | 23 out |
| Wednesday, August 20 |
| » Lost to Tigers (69-51), 4-3 | Sick's Stadium (24-36) | 48-72 | Lost 6 |
| » W: Mickey Lolich (16-6) L: Gene Brabender (9-10) | Fifth | 23 out |
| Thursday, August 21 |
| » Lost to Tigers (70-51), 7-6 | Sick's Stadium (24-37) | 48-73 | Lost 7 |
| » W: John Hiller (4-3) L: Jim Bouton (2-1) | Fifth | 23½ out |
| Friday, August 22 |
| » Lost to Indians (52-74), 9-8 | Sick's Stadium (24-38) | 48-74 | Lost 8 |
| » W: Steve Hargan (5-10) L: Fred Talbot (5-7) S: Stan Williams (11) | Fifth | 24½ out |
| Saturday, August 23 |
| » Lost to Indians (53-74), 7-3 | Sick's Stadium (24-39) | 48-75 | Lost 9 |
| » W: Sam McDowell (15-10) L: Marty Pattin (7-11) | Fifth | 25½ out |
| Sunday, August 24 |
| » Lost to Indians (54-74), 6-5 | Sick's Stadium (24-40) | 48-76 | Lost 10 |
| » W: Stan Williams (5-10) L: Fred Talbot (5-8) S: Ron Law (1) | Fifth | 26½ out |
| Tuesday, August 26 |
| » Defeated Orioles (87-41), 2-1 | Memorial Stadium (2-2) | 49-76 | |
| » W: Gene Brabender (10-10) L: Tom Phoebus (12-6) | Fifth | 26 out |
| Wednesday, August 27 |
| » Lost to Orioles (88-41), 7-2 | Memorial Stadium (2-3) | 49-77 | |
| » W: Mike Cuellar (18-10) L: George Brunet (7-11) | Fifth | 27 out |
| Thursday, August 28 |
| » Lost to Orioles (89-41), 4-3 | Memorial Stadium (2-4) | 49-78 | Lost 2 |
| » W: Eddie Watt (4-1) L: Dooley Womack (2-2) | Fifth | 27½ out |
| Friday, August 29 |
| » Lost to Tigers (75-54), 6-1 | Tiger Stadium (1-3) | 49-79 | Lost 3 |
| » W: Mickey Lolich (17-7) L: Steve Barber (2-4) | Sixth | 28½ out |
| Saturday, August 30 |
| » Lost to Tigers (76-54), 4-3 | Tiger Stadium (1-4) | 49-80 | Lost 4 |
| » W: Denny McLain (21-6) L: John O'Donoghue (1-2) | Sixth | 28½ out |
| Sunday, August 31 |
| » Lost to Tigers (77-54), 7-2 | Tiger Stadium (1-5) | 49-81 | Lost 5 |
| » W: Earl Wilson (12-8) L: Gene Brabender (10-11) | Fifth | 29½ out |
| Monday, September 1 |
| » Lost to Yankees (66-66), 6-1 | Yankee Stadium (2-2) | 49-82 | Lost 6 |
| » W: Mel Stottlemyre (18-11) L: George Brunet (7-12) | Sixth | 30 out |
| » Defeated Yankees (66-67), 5-1 | Yankee Stadium (3-2) | 50-82 | |
| » W: Dooley Womack (3-2) L: Steve Hamilton (3-4) | Sixth | 30 out |
| » Major-league debuts: Miguel Fuentes (Pilots) |
| Tuesday, September 2 |
| » Lost to Yankees (67-67), 5-4 | Yankee Stadium (3-3) | 50-83 | |
| » W: Stan Bahnsen (8-13) L: Gene Brabender (10-12) | Sixth | 31 out |
| Thursday, September 4 |
| » Lost to Royals (55-80), 5-3 | Sick's Stadium (24-41) | 50-84 | Lost 2 |
| » W: Dick Drago (8-11) L: John Gelnar (2-10) | Sixth | 32½ out |
| Friday, September 5 |
| » Defeated Royals (55-81), 5-4 | Sick's Stadium (25-41) | 51-84 | |
| » W: Gene Brabender (11-12) L: Moe Drabowsky (8-8) S: Bob Locker (10) | Sixth | 31½ out |
| Saturday, September 6 |
| » Lost to Royals (56-81), 6-2 | Sick's Stadium (25-42) | 51-85 | |
| » W: Wally Bunker (9-10) L: Bob Meyer (0-1) | Sixth | 32½ out |
| Sunday, September 7 |
| » Defeated Royals (56-82), 7-6 | Sick's Stadium (26-42) | 52-85 | |
| » W: Diego Segui (10-5) L: Moe Drabowsky (8-9) | Sixth | 32½ out |
| Monday, September 8 |
| » Defeated White Sox (54-83), 2-1 | Sick's Stadium (27-42) | 53-85 | Won 2 |
| » W: Steve Barber (3-4) L: Bart Johnson (0-1) S: John Gelnar (3) | Sixth | 31 out |
| » Defeated White Sox (54-84), 5-1 | Sick's Stadium (28-42) | 54-85 | Won 3 |
| » W: Miguel Fuentes (1-0) L: Gary Peters (9-14) | Sixth | 31 out |
| » Major-league debuts: Bart Johnson and Denny O'Toole (White Sox) |
| Tuesday, September 9 |
| » Major-league debuts: Tom Bradley and Marty Perez (Angels) |
| Wednesday, September 10 |
| » Defeated Athletics (76-64), 9-4 | Oakland-Alameda County Stadium (3-5) | 55-85 | Won 4 |
| » W: Gene Brabender (12-12) L: Chuck Dobson (14-12) S: Diego Segui (9) | Sixth | 30½ out |
| Thursday, September 11 |
| » Lost to Athletics (77-64), 6-3 | Oakland-Alameda County Stadium (3-6) | 55-86 | |
| » W: Jim Nash (8-7) L: Bob Meyer (0-2) S: Fred Talbot (1) | Sixth | 30½ out |
| Friday, September 12 |
| » Defeated Angels (61-80), 4-1 | Sick's Stadium (29-42) | 56-86 | |
| » W: George Brunet (8-12) L: Rudy May (8-12) | Sixth | 30½ out |
| » Tied Angels, 1-1 | Sick's Stadium (29-42) | 56-86 | |
| » Starters: Rickey Clark vs Skip Lockwood | Sixth | 30½ out |
| Saturday, September 13 |
| » Defeated Angels (61-81), 6-4 | Sick's Stadium (30-42) | 57-86 | Won 2 |
| » W: Diego Segui (11-5) L: Tom Murphy (9-14) | Fifth | 30 out |
| » Lost to Angels (62-81), 4-2 | Sick's Stadium (30-43) | 57-87 | |
| » W: Eddie Fisher (2-2) L: Miguel Fuentes (1-1) S: Ken Tatum (19) | Fifth | 30 out |
| Sunday, September 14 |
| » Lost to Angels (63-81), 4-2 | Sick's Stadium (30-44) | 57-88 | Lost 2 |
| » W: Andy Messersmith (15-9) L: Steve Barber (3-5) | Sixth | 30 out |
| Monday, September 15 |
| » Defeated Royals (61-85), 3-2 | Municipal Stadium (3-5) | 58-88 | |
| » W: Gene Brabender (13-12) L: Jerry Cram (0-1) S: Diego Segui (10) | Sixth | 30 out |
| Tuesday, September 16 |
| » Lost to Royals (62-85), 2-1 | Municipal Stadium (3-6) | 58-89 | |
| » W: Wally Bunker (11-10) L: Bob Meyer (0-3) | Sixth | 31 out |
| Wednesday, September 17 |
| » Lost to White Sox (61-87), 6-4 | Comiskey Park I (2-5) | 58-90 | Lost 2 |
| » W: Jerry Nyman (3-4) L: Marty Pattin (7-12) S: Wilbur Wood (14) | Sixth | 31½ out |
| » Lost to White Sox (62-87), 2-1 | Comiskey Park I (2-6) | 58-91 | Lost 3 |
| » W: Billy Wynne (6-6) L: Skip Lockwood (0-1) | Sixth | 31½ out |
| Friday, September 19 |
| » Lost to Twins (90-60), 2-1 | Metropolitan Stadium (0-7) | 58-92 | Lost 4 |
| » W: Dave Boswell (18-11) L: Steve Barber (3-6) | Fifth | 32 out |
| Saturday, September 20 |
| » Lost to Twins (91-60), 3-2 | Metropolitan Stadium (0-8) | 58-93 | Lost 5 |
| » W: Jim Perry (20-6) L: Diego Segui (11-6) | Sixth | 33 out |
| Sunday, September 21 |
| » Defeated Twins (91-61), 4-3 | Metropolitan Stadium (1-8) | 59-93 | |
| » W: John O'Donoghue (2-2) L: Jim Kaat (13-12) | Fifth | 32 out |
| Monday, September 22 |
| » Defeated Angels (68-85), 5-4 | Anaheim Stadium (4-3) | 60-93 | Won 2 |
| » W: Dooley Womack (4-2) L: Andy Messersmith (16-10) S: Diego Segui (11) | Sixth | 32 out |
| Tuesday, September 23 |
| » Lost to Angels |