| Wednesday, January 1 |
| Future Padre Roberto Rivera is born in Bayamon, P.R. |
| Wednesday, January 8 |
| Future Padre Brian Boehringer is born in St. Louis, MO. |
| Monday, January 27 |
| Future Padre Phil Plantier is born in Manchester, NH. |
| Saturday, February 15 |
| Future Padre Brian Williams is born in Lancaster, SC. |
| Tuesday, March 4 |
| Future Padre Ed Giovanola is born in Los Gatos, CA. |
| Tuesday, March 25 |
| Future Padre Paul Menhart is born in St. Louis, MO. Future Padre Scott Sanders is born in Hannibal, MO. |
| Friday, April 4 |
| Future Padre Carlos Reyes is born in Miami, FL. |
| Sunday, April 6 |
| Future Padre Bret Boone is born in ElCajon, CA. |
| Monday, April 7 |
| » Major-league debuts: Bob Didier (Braves) |
| Future Padre Ricky Bones is born in Salinas, P.R. |
| Tuesday, April 8 |
| » Defeated Astros (0-1), 2-1 | San Diego/Jack Murphy Stadium (1-0) | 1-0 | |
| » W: Dick Selma (1-0) L: Don Wilson (0-1) | Second | ½ out |
| Future Padre Pete Walker is born in Beverly, MA. |
| Wednesday, April 9 |
| » Defeated Astros (0-2), 2-0 | San Diego/Jack Murphy Stadium (2-0) | 2-0 | Won 2 |
| » W: Johnny Podres (1-0) L: Larry Dierker (0-1) S: Tommie Sisk (1) | Second | ½ out |
| Thursday, April 10 |
| » Defeated Astros (0-3), 2-0 | San Diego/Jack Murphy Stadium (3-0) | 3-0 | Won 3 |
| » W: Dick Kelley (1-0) L: Tom Griffin (0-1) S: Billy McCool (1) | First | -- |
| » Major-league debuts: Tom Griffin (Astros) |
| Friday, April 11 |
| » Lost to Giants (1-3), 8-0 | San Diego/Jack Murphy Stadium (3-1) | 3-1 | |
| » W: Ray Sadecki (1-0) L: Clay Kirby (0-1) | Second | 1 out |
| » Major-league debuts: Jerry Davanon and Clay Kirby (Padres) |
| Saturday, April 12 |
| » Lost to Giants (2-3), 5-1 | San Diego/Jack Murphy Stadium (3-2) | 3-2 | Lost 2 |
| » W: Juan Marichal (1-0) L: Al McBean (0-1) | Third | 1 out |
| Sunday, April 13 |
| » Lost to Giants (3-3), 5-1 | San Diego/Jack Murphy Stadium (3-3) | 3-3 | Lost 3 |
| » W: Gaylord Perry (1-1) L: Dick Selma (1-1) | Third | 2½ out |
| Monday, April 14 |
| Future Padre Brad Ausmus is born in New Haven, CT. |
| Tuesday, April 15 |
| » Lost to Dodgers (4-3), 14-0 | Dodger Stadium (0-1) | 3-4 | Lost 4 |
| » W: Claude Osteen (2-0) L: Johnny Podres (1-1) | Third | 2½ out |
| Wednesday, April 16 |
| » Lost to Dodgers (5-3), 9-1 | Dodger Stadium (0-2) | 3-5 | Lost 5 |
| » W: Bill Singer (2-0) L: Dick Kelley (1-1) | Fourth | 3½ out |
| Thursday, April 17 |
| » Lost to Giants (4-4), 5-4 | Candlestick Park (0-1) | 3-6 | Lost 6 |
| » W: Juan Marichal (2-0) L: Clay Kirby (0-2) S: Joe Gibbon (1) | Fifth | 4½ out |
| Friday, April 18 |
| » Defeated Giants (4-5), 3-1 | Candlestick Park (1-1) | 4-6 | |
| » W: Al Santorini (1-0) L: Ray Sadecki (1-1) S: Frank Reberger (1) | Fifth | 4 out |
| Saturday, April 19 |
| » Lost to Giants (5-5), 5-3 | Candlestick Park (1-2) | 4-7 | |
| » W: Gaylord Perry (2-2) L: Dick Selma (1-2) | Fifth | 5 out |
| Sunday, April 20 |
| » Lost to Giants (6-5), 3-2 | Candlestick Park (1-3) | 4-8 | Lost 2 |
| » W: Bobby Bolin (1-1) L: Tommie Sisk (0-1) S: Frank Linzy (1) | Fifth | 5 out |
| Monday, April 21 |
| » Lost to Braves (10-3), 5-2 | San Diego/Jack Murphy Stadium (3-4) | 4-9 | Lost 3 |
| » W: Ron Reed (2-0) L: Johnny Podres (1-2) S: Cecil Upshaw (4) | Fifth | 6 out |
| Tuesday, April 22 |
| » Defeated Braves (10-4), 8-4 | San Diego/Jack Murphy Stadium (4-4) | 5-9 | |
| » W: Dick Selma (2-2) L: Claude Raymond (0-1) | Fifth | 5 out |
| Future Padre George Williams is born in LaCrosse, WI. |
| Wednesday, April 23 |
| » Lost to Astros (4-12), 4-0 | Astrodome (0-1) | 5-10 | |
| » W: Larry Dierker (2-2) L: Clay Kirby (0-3) | Fourth | 5½ out |
| Thursday, April 24 |
| » Defeated Astros (4-13), 4-1 | Astrodome (1-1) | 6-10 | |
| » W: Jack Baldschun (1-0) L: Jack Billingham (0-2) | Fourth | 4½ out |
| Friday, April 25 |
| » Lost to Reds (8-6), 4-1 | San Diego/Jack Murphy Stadium (4-5) | 6-11 | |
| » W: Jim Maloney (2-0) L: Tommie Sisk (0-2) | Fifth | 5½ out |
| Saturday, April 26 |
| » Defeated Reds (8-7), 5-2 | San Diego/Jack Murphy Stadium (5-5) | 7-11 | |
| » W: Jack Baldschun (2-0) L: Jim Merritt (1-1) | Fourth | 4½ out |
| Sunday, April 27 |
| » Defeated Reds (8-8), 5-2 | San Diego/Jack Murphy Stadium (6-5) | 8-11 | Won 2 |
| » W: Clay Kirby (1-3) L: George Culver (1-1) S: Frank Reberger (2) | Fourth | 4 out |
| » Defeated Reds (8-9), 10-9 | San Diego/Jack Murphy Stadium (7-5) | 9-11 | Won 3 |
| » W: Gary Ross (1-0) L: Wayne Granger (1-1) | Fourth | 4 out |
| Monday, April 28 |
| » Lost to Dodgers (13-6), 4-3 | San Diego/Jack Murphy Stadium (7-6) | 9-12 | |
| » W: Claude Osteen (4-1) L: Dick Kelley (1-2) S: Jim Brewer (2) | Fourth | 5 out |
| Tuesday, April 29 |
| » Lost to Dodgers (14-6), 2-1 | San Diego/Jack Murphy Stadium (7-7) | 9-13 | Lost 2 |
| » W: Joe Moeller (1-0) L: Al Santorini (1-1) S: Jim Brewer (3) | Fourth | 6 out |
| Wednesday, April 30 |
| » Lost to Braves (14-7), 6-3 | Atlanta-Fulton County Stadium (0-1) | 9-14 | Lost 3 |
| » W: Phil Niekro (4-1) L: Leon Everitt (0-1) | Fourth | 7 out |
| Thursday, May 1 |
| » Defeated Braves (14-8), 4-3 | Atlanta-Fulton County Stadium (1-1) | 10-14 | |
| » W: Jack Baldschun (3-0) L: Cecil Upshaw (0-1) | Fourth | 6 out |
| Friday, May 2 |
| » Defeated Reds (9-13), 8-5 | Crosley Field (1-0) | 11-14 | Won 2 |
| » W: Johnny Podres (2-2) L: George Culver (1-3) S: Frank Reberger (3) | Second | 5 out |
| Saturday, May 3 |
| » Defeated Reds (9-14), 13-5 | Crosley Field (2-0) | 12-14 | Won 3 |
| » W: Joe Niekro (1-1) L: Tony Cloninger (0-4) S: Tommie Sisk (2) | Third | 5 out |
| Sunday, May 4 |
| » Lost to Reds (10-14), 3-2 | Crosley Field (2-1) | 12-15 | |
| » W: Jack Fisher (1-0) L: Al Santorini (1-2) S: Clay Carroll (2) | Fourth | 6½ out |
| » Lost to Reds (11-14), 12-0 | Crosley Field (2-2) | 12-16 | Lost 2 |
| » W: Tony Cloninger (1-4) L: Gary Ross (1-1) | Fourth | 6½ out |
| Tuesday, May 6 |
| » Defeated Pirates (15-11), 4-2 | Forbes Field (1-0) | 13-16 | |
| » W: Dick Kelley (2-2) L: Steve Blass (2-2) S: Frank Reberger (4) | Third | 5½ out |
| Wednesday, May 7 |
| » Lost to Pirates (16-11), 2-0 | Forbes Field (1-1) | 13-17 | |
| » W: Bob Veale (3-3) L: Clay Kirby (1-4) S: Chuck Hartenstein (5) | Fourth | 6½ out |
| Friday, May 9 |
| » Lost to Cardinals (12-16), 7-6 | Busch Stadium II (0-1) | 13-18 | Lost 2 |
| » W: Mike Torrez (1-0) L: Frank Reberger (0-1) S: Joe Hoerner (4) | Fourth | 7 out |
| Saturday, May 10 |
| » Defeated Cardinals (12-17), 5-3 | Busch Stadium II (1-1) | 14-18 | |
| » W: Johnny Podres (3-2) L: Steve Carlton (2-4) S: Frank Reberger (5) | Fifth | 7 out |
| Sunday, May 11 |
| » Defeated Cardinals (12-18), 4-2 | Busch Stadium II (2-1) | 15-18 | Won 2 |
| » W: Jack Baldschun (4-0) L: Dave Giusti (2-4) S: Tommie Sisk (3) | Fourth | 7 out |
| Monday, May 12 |
| » Lost to Cubs (21-11), 2-0 | Wrigley Field (0-1) | 15-19 | |
| » W: Fergie Jenkins (5-2) L: Gary Ross (1-2) | Fifth | 7½ out |
| Tuesday, May 13 |
| » Lost to Cubs (22-11), 19-0 | Wrigley Field (0-2) | 15-20 | Lost 2 |
| » W: Dick Selma (3-3) L: Dick Kelley (2-3) | Fifth | 8½ out |
| Wednesday, May 14 |
| » Lost to Cubs (23-11), 3-2 | Wrigley Field (0-3) | 15-21 | Lost 3 |
| » W: Don Nottebart (1-0) L: Johnny Podres (3-3) | Fifth | 8½ out |
| Friday, May 16 |
| » Defeated Cardinals (14-19), 2-1 | San Diego/Jack Murphy Stadium (8-7) | 16-21 | |
| » W: Billy McCool (1-0) L: Ray Washburn (2-4) | Fifth | 9 out |
| Saturday, May 17 |
| » Lost to Cardinals (15-19), 5-1 | San Diego/Jack Murphy Stadium (8-8) | 16-22 | |
| » W: Steve Carlton (3-4) L: Clay Kirby (1-5) | Fifth | 9½ out |
| Sunday, May 18 |
| » Lost to Cardinals (16-19), 6-5 | San Diego/Jack Murphy Stadium (8-9) | 16-23 | Lost 2 |
| » W: Dave Giusti (3-4) L: Gary Ross (1-3) S: Gary Waslewski (1) | Fifth | 10½ out |
| Tuesday, May 20 |
| » Lost to Pirates (18-18), 6-3 | San Diego/Jack Murphy Stadium (8-10) | 16-24 | Lost 3 |
| » W: Jim Bunning (3-4) L: Joe Niekro (1-2) S: Chuck Hartenstein (6) | Fifth | 11 out |
| Wednesday, May 21 |
| » Lost to Pirates (19-18), 11-1 | San Diego/Jack Murphy Stadium (8-11) | 16-25 | Lost 4 |
| » W: Bob Moose (4-2) L: Tommie Sisk (0-3) | Sixth | 11 out |
| Thursday, May 22 |
| » Lost to Pirates (20-18), 7-1 | San Diego/Jack Murphy Stadium (8-12) | 16-26 | Lost 5 |
| » W: Steve Blass (3-2) L: Clay Kirby (1-6) | Sixth | 12 out |
| Friday, May 23 |
| » Lost to Cubs (27-14), 6-0 | San Diego/Jack Murphy Stadium (8-13) | 16-27 | Lost 6 |
| » W: Dick Selma (4-3) L: Gary Ross (1-4) | Sixth | 12 out |
| Saturday, May 24 |
| » Lost to Cubs (28-14), 7-5 | San Diego/Jack Murphy Stadium (8-14) | 16-28 | Lost 7 |
| » W: Ted Abernathy (3-0) L: Dick Kelley (2-4) S: Phil Regan (3) | Sixth | 12 out |
| » Major-league debuts: John Sipin (Padres) |
| Sunday, May 25 |
| » Defeated Cubs (28-15), 10-2 | San Diego/Jack Murphy Stadium (9-14) | 17-28 | |
| » W: Johnny Podres (4-3) L: Rich Nye (0-3) | Sixth | 12½ out |
| » Lost to Cubs (29-15), 1-0 | San Diego/Jack Murphy Stadium (9-15) | 17-29 | |
| » W: Ted Abernathy (4-0) L: Joe Niekro (1-3) | Sixth | 12½ out |
| » Major-league debuts: Sonny Ruberto (Padres) |
| Tuesday, May 27 |
| » Defeated Mets (18-23), 3-2 | Shea Stadium (1-0) | 18-29 | |
| » W: Al Santorini (2-2) L: Jim McAndrew (0-2) | Sixth | 13 out |
| Wednesday, May 28 |
| » Lost to Mets (19-23), 1-0 | Shea Stadium (1-1) | 18-30 | |
| » W: Tug McGraw (4-1) L: Billy McCool (1-1) | Sixth | 13 out |
| Friday, May 30 |
| » Defeated Expos (11-31), 3-2 | Parc Jarry (1-0) | 19-30 | |
| » W: Jack Baldschun (5-0) L: Dan McGinn (2-4) | Sixth | 12 out |
| Saturday, May 31 |
| » Defeated Expos (11-32), 6-2 | Parc Jarry (2-0) | 20-30 | Won 2 |
| » W: Joe Niekro (2-3) L: Larry Jaster (1-4) | Sixth | 11 out |
| Sunday, June 1 |
| » Defeated Expos (11-33), 5-2 | Parc Jarry (3-0) | 21-30 | Won 3 |
| » W: Johnny Podres (5-3) L: Jerry Robertson (0-2) S: Tommie Sisk (4) | Sixth | 10 out |
| Monday, June 2 |
| » Defeated Phillies (18-26), 6-4 | Shibe Park (1-0) | 22-30 | Won 4 |
| » W: Al Santorini (3-2) L: Jerry Johnson (2-6) S: Gary Ross (1) | Sixth | 10 out |
| Tuesday, June 3 |
| » Defeated Phillies (18-27), 6-5 | Shibe Park (2-0) | 23-30 | Won 5 |
| » W: Clay Kirby (2-6) L: Woodie Fryman (5-2) S: Billy McCool (2) | Sixth | 9 out |
| Wednesday, June 4 |
| » Defeated Phillies (18-28), 3-0 | Shibe Park (3-0) | 24-30 | Won 6 |
| » W: Dick Kelley (3-4) L: Bill Champion (0-1) S: Billy McCool (3) | Sixth | 8 out |
| » Major-league debuts: Billy Champion (Phillies) |
| Friday, June 6 |
| » Lost to Mets (26-23), 5-3 | San Diego/Jack Murphy Stadium (9-16) | 24-31 | |
| » W: Gary Gentry (5-4) L: Gary Ross (1-5) S: Ron Taylor (3) | Sixth | 9 out |
| Saturday, June 7 |
| » Lost to Mets (27-23), 4-1 | San Diego/Jack Murphy Stadium (9-17) | 24-32 | Lost 2 |
| » W: Jerry Koosman (3-3) L: Johnny Podres (5-4) | Sixth | 9 out |
| Sunday, June 8 |
| » Lost to Mets (28-23), 3-2 | San Diego/Jack Murphy Stadium (9-18) | 24-33 | Lost 3 |
| » W: Tom Seaver (9-3) L: Al Santorini (3-3) S: Ron Taylor (4) | Sixth | 10½ out |
| Tuesday, June 10 |
| » Lost to Expos (13-37), 7-4 | San Diego/Jack Murphy Stadium (9-19) | 24-34 | Lost 4 |
| » W: Roy Face (3-1) L: Jack Baldschun (5-1) | Sixth | 10½ out |
| Wednesday, June 11 |
| » Defeated Expos (13-38), 6-5 | San Diego/Jack Murphy Stadium (10-19) | 25-34 | |
| » W: Billy McCool (2-1) L: Howie Reed (0-1) | Sixth | 10½ out |
| Thursday, June 12 |
| » Lost to Expos (14-38), 4-1 | San Diego/Jack Murphy Stadium (10-20) | 25-35 | |
| » W: Howie Reed (1-1) L: Tommie Sisk (0-4) | Sixth | 10½ out |
| Friday, June 13 |
| » Lost to Phillies (21-32), 6-1 | San Diego/Jack Murphy Stadium (10-21) | 25-36 | Lost 2 |
| » W: Rick Wise (6-5) L: Johnny Podres (5-5) | Sixth | 10½ out |
| Saturday, June 14 |
| » Lost to Phillies (22-32), 7-5 | San Diego/Jack Murphy Stadium (10-22) | 25-37 | Lost 3 |
| » W: Jerry Johnson (3-6) L: Al Santorini (3-4) S: Turk Farrell (2) | Sixth | 10½ out |
| Sunday, June 15 |
| » Lost to Phillies (23-32), 5-4 | San Diego/Jack Murphy Stadium (10-23) | 25-38 | Lost 4 |
| » W: Woodie Fryman (6-3) L: Clay Kirby (2-7) S: John Boozer (1) | Fifth | 11½ out |
| Monday, June 16 |
| » Defeated Dodgers (33-26), 3-2 | Dodger Stadium (1-2) | 26-38 | |
| » W: Jack Baldschun (6-1) L: Al McBean (1-2) S: Tommie Sisk (5) | Fifth | 12 out |
| Tuesday, June 17 |
| » Lost to Dodgers (34-26), 7-3 | Dodger Stadium (1-3) | 26-39 | |
| » W: Pete Mikkelsen (2-2) L: Gary Ross (1-6) S: Jim Brewer (8) | Sixth | 13½ out |
| » Lost to Dodgers (35-26), 11-0 | Dodger Stadium (1-4) | 26-40 | Lost 2 |
| » W: Alan Foster (2-4) L: Joe Niekro (2-4) | Sixth | 13½ out |
| » Major-league debuts: Steve Arlin (Padres) |
| Wednesday, June 18 |
| » Lost to Dodgers (36-26), 10-1 | Dodger Stadium (1-5) | 26-41 | Lost 3 |
| » W: Don Sutton (10-5) L: Johnny Podres (5-6) | Sixth | 13½ out |
| Thursday, June 19 |
| » Lost to Astros (31-36), 4-2 | Astrodome (1-2) | 26-42 | Lost 4 |
| » W: Don Wilson (6-6) L: Al Santorini (3-5) | Sixth | 14 out |
| Friday, June 20 |
| » Lost to Astros (32-36), 6-1 | Astrodome (1-3) | 26-43 | Lost 5 |
| » W: Larry Dierker (9-5) L: Clay Kirby (2-8) | Sixth | 15½ out |
| » Lost to Astros (33-36), 3-1 | Astrodome (1-4) | 26-44 | Lost 6 |
| » W: Jim Ray (3-2) L: Tommie Sisk (0-5) S: Fred Gladding (13) | Sixth | 15½ out |
| Saturday, June 21 |
| » Lost to Astros (34-36), 4-0 | Astrodome (1-5) | 26-45 | Lost 7 |
| » W: Tom Griffin (4-3) L: Dick Kelley (3-5) | Fifth | 15½ out |
| Sunday, June 22 |
| » Lost to Astros (35-36), 2-0 | Astrodome (1-6) | 26-46 | Lost 8 |
| » W: Denny Lemaster (7-7) L: Joe Niekro (2-5) | Sixth | 16½ out |
| Monday, June 23 |
| » Lost to Reds (33-29), 5-0 | Crosley Field (2-3) | 26-47 | Lost 9 |
| » W: Jim Merritt (7-3) L: Gary Ross (1-7) | Sixth | 17½ out |
| Tuesday, June 24 |
| » Lost to Reds (34-29), 4-3 | Crosley Field (2-4) | 26-48 | Lost 10 |
| » W: Clay Carroll (10-3) L: Billy McCool (2-2) | Sixth | 17½ out |
| Wednesday, June 25 |
| » Lost to Reds (35-29), 4-0 | Crosley Field (2-5) | 26-49 | Lost 11 |
| » W: George Culver (5-6) L: Clay Kirby (2-9) S: Wayne Granger (8) | Sixth | 18 out |
| Thursday, June 26 |
| Future Padre Rodney Myers is born in Rockford, IL. |
| Friday, June 27 |
| » Defeated Dodgers (41-29), 5-0 | San Diego/Jack Murphy Stadium (11-23) | 27-49 | |
| » W: Joe Niekro (3-5) L: Don Sutton (11-6) | Sixth | 17 out |
| Saturday, June 28 |
| » Lost to Dodgers (42-29), 19-0 | San Diego/Jack Murphy Stadium (11-24) | 27-50 | |
| » W: Don Drysdale (4-3) L: Steve Arlin (0-1) | Sixth | 18 out |
| Sunday, June 29 |
| » Lost to Dodgers (43-29), 3-1 | San Diego/Jack Murphy Stadium (11-25) | 27-51 | Lost 2 |
| » W: Alan Foster (3-4) L: Al Santorini (3-6) S: Jim Brewer (12) | Sixth | 19 out |
| Monday, June 30 |
| » Lost to Giants (39-36), 6-1 | San Diego/Jack Murphy Stadium (11-26) | 27-52 | Lost 3 |
| » W: Mike McCormick (5-4) L: Clay Kirby (2-10) | Sixth | 20 out |
| Tuesday, July 1 |
| » Lost to Giants (40-36), 5-4 | San Diego/Jack Murphy Stadium (11-27) | 27-53 | Lost 4 |
| » W: Bobby Bolin (5-4) L: Billy McCool (2-3) | Sixth | 21 out |
| Wednesday, July 2 |
| » Lost to Giants (41-36), 6-3 | San Diego/Jack Murphy Stadium (11-28) | 27-54 | Lost 5 |
| » W: Juan Marichal (10-3) L: Joe Niekro (3-6) | Sixth | 21½ out |
| Friday, July 4 |
| » Lost to Astros (41-40), 4-0 | San Diego/Jack Murphy Stadium (11-29) | 27-55 | Lost 6 |
| » W: Larry Dierker (11-5) L: Al Santorini (3-7) | Sixth | 21½ out |
| Saturday, July 5 |
| » Defeated Astros (41-41), 9-8 | San Diego/Jack Murphy Stadium (12-29) | 28-55 | |
| » W: Frank Reberger (1-1) L: Skip Guinn (0-2) | Sixth | 21½ out |
| Sunday, July 6 |
| » Lost to Astros (42-41), 3-2 | San Diego/Jack Murphy Stadium (12-30) | 28-56 | |
| » W: Jim Ray (4-2) L: Dave Roberts (0-1) S: Denny Lemaster (1) | Sixth | 20½ out |
| » Defeated Astros (42-42), 1-0 | San Diego/Jack Murphy Stadium (13-30) | 29-56 | |
| » W: Dick Kelley (4-5) L: Jack Billingham (4-4) | Sixth | 20½ out |
| » Major-league debuts: Dave Roberts (Padres) |
| Monday, July 7 |
| » Lost to Reds (42-35), 5-3 | San Diego/Jack Murphy Stadium (13-31) | 29-57 | |
| » W: Pedro Ramos (2-2) L: Tommie Sisk (0-6) S: Wayne Granger (11) | Sixth | 21½ out |
| Tuesday, July 8 |
| » Lost to Reds (43-35), 8-2 | San Diego/Jack Murphy Stadium (13-32) | 29-58 | Lost 2 |
| » W: Tony Cloninger (6-11) L: Al Santorini (3-8) | Sixth | 21½ out |
| Wednesday, July 9 |
| » Lost to Reds (44-35), 4-3 | San Diego/Jack Murphy Stadium (13-33) | 29-59 | Lost 3 |
| » W: Jim Merritt (9-3) L: Clay Kirby (2-11) S: Wayne Granger (12) | Sixth | 22½ out |
| Thursday, July 10 |
| » Lost to Braves (50-37), 3-1 | San Diego/Jack Murphy Stadium (13-34) | 29-60 | Lost 4 |
| » W: Jim Britton (3-1) L: Dave Roberts (0-2) S: Cecil Upshaw (17) | Sixth | 22½ out |
| Friday, July 11 |
| » Lost to Braves (51-37), 6-3 | San Diego/Jack Murphy Stadium (13-35) | 29-61 | Lost 5 |
| » W: Pat Jarvis (7-6) L: Jack Baldschun (6-2) S: Paul Doyle (1) | Sixth | 23 out |
| Saturday, July 12 |
| » Defeated Braves (51-38), 7-5 | San Diego/Jack Murphy Stadium (14-35) | 30-61 | |
| » W: Al Santorini (4-8) L: George Stone (9-3) S: Billy McCool (4) | Sixth | 22½ out |
| Sunday, July 13 |
| » Defeated Braves (51-39), 1-0 | San Diego/Jack Murphy Stadium (15-35) | 31-61 | Won 2 |
| » W: Joe Niekro (4-6) L: Phil Niekro (14-7) | Sixth | 21½ out |
| Tuesday, July 15 |
| » Defeated Giants (50-41), 10-3 | Candlestick Park (2-3) | 32-61 | Won 3 |
| » W: Clay Kirby (3-11) L: Juan Marichal (12-4) S: Gary Ross (2) | Sixth | 21 out |
| Wednesday, July 16 |
| » Lost to Giants (51-41), 4-3 | Candlestick Park (2-4) | 32-62 | |
| » W: Gaylord Perry (11-7) L: Dave Roberts (0-3) | Sixth | 22 out |
| Friday, July 18 |
| » Lost to Braves (54-41), 6-2 | Atlanta-Fulton County Stadium (1-2) | 32-63 | Lost 2 |
| » W: Ron Reed (8-7) L: Al Santorini (4-9) | Sixth | 23 out |
| » Lost to Braves (55-41), 6-3 | Atlanta-Fulton County Stadium (1-3) | 32-64 | Lost 3 |
| » W: Jim Britton (4-1) L: Gary Ross (1-8) S: Cecil Upshaw (18) | Sixth | 23 out |
| Saturday, July 19 |
| » Defeated Braves (55-42), 6-1 | Atlanta-Fulton County Stadium (2-3) | 33-64 | |
| » W: Joe Niekro (5-6) L: George Stone (9-4) | Sixth | 22 out |
| Sunday, July 20 |
| » Lost to Braves (56-42), 10-0 | Atlanta-Fulton County Stadium (2-4) | 33-65 | |
| » W: Pat Jarvis (8-7) L: Clay Kirby (3-12) | Sixth | 23 out |
| Thursday, July 24 |
| » Lost to Pirates (48-48), 4-3 | Forbes Field (1-2) | 33-66 | Lost 2 |
| » W: Dock Ellis (7-10) L: Gary Ross (1-9) | Sixth | 24 out |
| Friday, July 25 |
| » Defeated Pirates (48-49), 3-2 | Forbes Field (2-2) | 34-66 | |
| » W: Joe Niekro (6-6) L: Steve Blass (9-7) | Sixth | 23 out |
| Saturday, July 26 |
| » Lost to Pirates (49-49), 4-3 | Forbes Field (2-3) | 34-67 | |
| » W: Bob Moose (7-2) L: Billy McCool (2-4) | Sixth | 23 out |
| Sunday, July 27 |
| » Lost to Pirates (50-49), 4-1 | Forbes Field (2-4) | 34-68 | Lost 2 |
| » W: Jim Bunning (9-7) L: Clay Kirby (3-13) S: Bob Moose (2) | Sixth | 24 out |
| Monday, July 28 |
| » Lost to Cardinals (53-49), 2-1 | Busch Stadium II (2-2) | 34-69 | Lost 3 |
| » W: Chuck Taylor (3-0) L: Dick Kelley (4-6) | Sixth | 24½ out |
| Tuesday, July 29 |
| » Lost to Cardinals (54-49), 10-4 | Busch Stadium II (2-3) | 34-70 | Lost 4 |
| » W: Mudcat Grant (5-9) L: Billy McCool (2-5) | Sixth | 25 out |
| Wednesday, July 30 |
| » Lost to Cardinals (55-49), 5-2 | Busch Stadium II (2-4) | 34-71 | Lost 5 |
| » W: Bob Gibson (13-8) L: Joe Niekro (6-7) | Sixth | 25½ out |
| Friday, August 1 |
| » Lost to Cubs (65-41), 5-2 | Wrigley Field (0-4) | 34-72 | Lost 6 |
| » W: Bill Hands (12-8) L: Clay Kirby (3-14) S: Phil Regan (11) | Sixth | 25½ out |
| Saturday, August 2 |
| » Lost to Cubs (66-41), 4-1 | Wrigley Field (0-5) | 34-73 | Lost 7 |
| » W: Ken Holtzman (13-5) L: Al Santorini (4-10) | Sixth | 25½ out |
| Sunday, August 3 |
| » Lost to Cubs (67-41), 4-3 | Wrigley Field (0-6) | 34-74 | Lost 8 |
| » W: Dick Selma (11-4) L: Joe Niekro (6-8) S: Phil Regan (12) | Sixth | 25½ out |
| Tuesday, August 5 |
| » Lost to Cardinals (59-50), 2-1 | San Diego/Jack Murphy Stadium (15-36) | 34-75 | Lost 9 |
| » W: Bob Gibson (14-8) L: Dick Kelley (4-7) | Sixth | 27 out |
| Wednesday, August 6 |
| » Defeated Cardinals (59-51), 3-2 | San Diego/Jack Murphy Stadium (16-36) | 35-75 | |
| » W: Billy McCool (3-5) L: Steve Carlton (13-6) | Sixth | 26½ out |
| Thursday, August 7 |
| » Lost to Cardinals (60-51), 2-1 | San Diego/Jack Murphy Stadium (16-37) | 35-76 | |
| » W: Mike Torrez (7-4) L: Al Santorini (4-11) | Sixth | 27 out |
| Friday, August 8 |
| » Lost to Pirates (56-54), 7-1 | San Diego/Jack Murphy Stadium (16-38) | 35-77 | Lost 2 |
| » W: Bob Veale (7-11) L: Joe Niekro (6-9) | Sixth | 28 out |
| Sunday, August 10 |
| » Lost to Pirates (57-54), 7-5 | San Diego/Jack Murphy Stadium (16-39) | 35-78 | Lost 3 |
| » W: Dock Ellis (8-12) L: Dick Kelley (4-8) S: Joe Gibbon (7) | Sixth | 30 out |
| » Lost to Pirates (58-54), 8-6 | San Diego/Jack Murphy Stadium (16-40) | 35-79 | Lost 4 |
| » W: Steve Blass (12-7) L: Clay Kirby (3-15) S: Joe Gibbon (8) | Sixth | 30 out |
| Tuesday, August 12 |
| » Lost to Cubs (72-43), 4-0 | San Diego/Jack Murphy Stadium (16-41) | 35-80 | Lost 5 |
| » W: Fergie Jenkins (16-10) L: Al Santorini (4-12) | Fifth | 30 out |
| Wednesday, August 13 |
| » Lost to Cubs (73-43), 4-2 | San Diego/Jack Murphy Stadium (16-42) | 35-81 | Lost 6 |
| » W: Bill Hands (15-8) L: Joe Niekro (6-10) | Fifth | 31 out |
| Saturday, August 16 |
| » Lost to Mets (63-51), 2-0 | Shea Stadium (1-2) | 35-82 | Lost 7 |
| » W: Tom Seaver (17-7) L: Tommie Sisk (0-7) S: Ron Taylor (11) | Sixth | 31½ out |
| » Lost to Mets (64-51), 2-1 | Shea Stadium (1-3) | 35-83 | Lost 8 |
| » W: Jim McAndrew (4-5) L: Gary Ross (1-10) S: Tug McGraw (8) | Sixth | 31½ out |
| Sunday, August 17 |
| » Lost to Mets (65-51), 3-2 | Shea Stadium (1-4) | 35-84 | Lost 9 |
| » W: Jerry Koosman (10-8) L: Joe Niekro (6-11) | Fifth | 32 out |
| » Lost to Mets (66-51), 3-2 | Shea Stadium (1-5) | 35-85 | Lost 10 |
| » W: Don Cardwell (5-9) L: Clay Kirby (3-16) S: Ron Taylor (12) | Fifth | 32 out |
| Tuesday, August 19 |
| » Defeated Expos (38-84), 5-4 | Parc Jarry (4-0) | 36-85 | |
| » W: Al Santorini (5-12) L: Steve Renko (2-5) S: Jack Baldschun (1) | Fifth | 31½ out |
| Wednesday, August 20 |
| » Lost to Expos (39-84), 11-10 | Parc Jarry (4-1) | 36-86 | |
| » W: Bill Stoneman (8-15) L: Gary Ross (1-11) | Fifth | 32 out |
| Thursday, August 21 |
| » Defeated Expos (39-85), 1-0 | Parc Jarry (5-1) | 37-86 | |
| » W: Joe Niekro (7-11) L: Jerry Robertson (4-10) | Sixth | 31½ out |
| Future Padre Andujar Cedeno is born in La Romana, D.R. |
| Friday, August 22 |
| » Lost to Phillies (50-72), 10-0 | Shibe Park (3-1) | 37-87 | |
| » W: Rick Wise (11-10) L: Clay Kirby (3-17) | Sixth | 31 out |
| Saturday, August 23 |
| » Lost to Phillies (51-72), 7-6 | Shibe Park (3-2) | 37-88 | Lost 2 |
| » W: Lowell Palmer (2-6) L: Frank Reberger (1-2) S: Turk Farrell (3) | Sixth | 31 out |
| Sunday, August 24 |
| » Lost to Phillies (52-72), 6-4 | Shibe Park (3-3) | 37-89 | Lost 3 |
| » W: Woodie Fryman (10-10) L: Tommie Sisk (0-8) | Sixth | 32 out |
| Tuesday, August 26 |
| » Lost to Mets (72-52), 8-4 | San Diego/Jack Murphy Stadium (16-43) | 37-90 | Lost 4 |
| » W: Tom Seaver (18-7) L: Tommie Sisk (0-9) | Sixth | 33½ out |
| » Lost to Mets (73-52), 3-0 | San Diego/Jack Murphy Stadium (16-44) | 37-91 | Lost 5 |
| » W: Jim McAndrew (6-5) L: Joe Niekro (7-12) | Sixth | 33½ out |
| Wednesday, August 27 |
| » Lost to Mets (74-52), 4-1 | San Diego/Jack Murphy Stadium (16-45) | 37-92 | Lost 6 |
| » W: Jerry Koosman (12-8) L: Clay Kirby (3-18) | Sixth | 34½ out |
| Friday, August 29 |
| » Defeated Expos (40-92), 3-0 | San Diego/Jack Murphy Stadium (17-45) | 38-92 | |
| » W: Al Santorini (6-12) L: Mike Wegener (4-11) | Sixth | 35 out |
| Sunday, August 31 |
| » Defeated Expos (40-93), 5-2 | San Diego/Jack Murphy Stadium (18-45) | 39-92 | Won 2 |
| » W: Gary Ross (2-11) L: Jerry Robertson (4-12) S: Billy McCool (5) | Sixth | 34½ out |
| » Lost to Expos (41-93), 6-1 | San Diego/Jack Murphy Stadium (18-46) | 39-93 | |
| » W: Steve Renko (3-6) L: Joe Niekro (7-13) | Sixth | 34½ out |
| Monday, September 1 |
| » Defeated Phillies (52-79), 5-2 | San Diego/Jack Murphy Stadium (19-46) | 40-93 | |
| » W: Clay Kirby (4-18) L: Grant Jackson (12-13) S: Gary Ross (3) | Sixth | 34½ out |
| Tuesday, September 2 |
| » Lost to Phillies (53-79), 2-0 | San Diego/Jack Murphy Stadium (19-47) | 40-94 | |
| » W: Bill Champion (5-7) L: Tommie Sisk (0-10) | Sixth | 35 out |
| Wednesday, September 3 |
| » Lost to Phillies (54-79), 9-1 | San Diego/Jack Murphy Stadium (19-48) | 40-95 | Lost 2 |
| » W: Woodie Fryman (11-11) L: Al Santorini (6-13) | Sixth | 36 out |
| Thursday, September 4 |
| » Defeated Dodgers (74-60), 3-0 | San Diego/Jack Murphy Stadium (20-48) | 41-95 | |
| » W: Gary Ross (3-11) L: Bill Singer (17-9) | Sixth | 35½ out |
| Friday, September 5 |
| » Defeated Dodgers (74-61), 4-1 | San Diego/Jack Murphy Stadium (21-48) | 42-95 | Won 2 |
| » W: Joe Niekro (8-13) L: Jim Bunning (12-10) | Sixth | 34½ out |
| » Major-league debuts: Jerry Morales (Padres) |
| Saturday, September 6 |
| » Defeated Dodgers (74-62), 3-1 | San Diego/Jack Murphy Stadium (22-48) | 43-95 | Won 3 |
| » W: Tommie Sisk (1-10) L: Don Sutton (15-14) S: Billy McCool (6) | Sixth | 34½ out |
| Sunday, September 7 |
| » Defeated Dodgers (74-63), 4-2 | San Diego/Jack Murphy Stadium (23-48) | 44-95 | Won 4 |
| » W: Al Santorini (7-13) L: Claude Osteen (18-12) S: Billy McCool (7) | Sixth | 33½ out |
| Monday, September 8 |
| » Lost to Astros (73-65), 9-2 | Astrodome (1-7) | 44-96 | |
| » W: Tom Griffin (10-6) L: Mike Corkins (0-1) | Sixth | 33½ out |
| » Major-league debuts: Mike Corkins and Fred Kendall (Padres) |
| Tuesday, September 9 |
| » Lost to Astros (74-65), 9-2 | Astrodome (1-8) | 44-97 | Lost 2 |
| » W: Larry Dierker (19-10) L: Joe Niekro (8-14) | Sixth | 34 out |
| Wednesday, September 10 |
| » Defeated Reds (76-63), 2-1 | Crosley Field (3-5) | 45-97 | |
| » W: Clay Kirby (5-18) L: Tony Cloninger (9-16) | Fifth | 33 out |
| Thursday, September 11 |
| » Lost to Reds (77-63), 6-4 | Crosley Field (3-6) | 45-98 | |
| » W: Gary Nolan (7-5) L: Tommie Sisk (1-11) S: Wayne Granger (21) | Sixth | 33½ out |
| Friday, September 12 |
| » Lost to Dodgers (77-65), 5-3 | Dodger Stadium (1-6) | 45-99 | Lost 2 |
| » W: Bill Singer (19-9) L: Gary Ross (3-12) S: Jim Brewer (20) | Sixth | 34½ out |
| Saturday, September 13 |
| » Lost to Dodgers (78-65), 7-2 | Dodger Stadium (1-7) | 45-100 | Lost 3 |
| » W: Jim Bunning (13-10) L: Joe Niekro (8-15) | Sixth | 35½ out |
| Sunday, September 14 |
| » Lost to Dodgers (79-65), 3-1 | Dodger Stadium (1-8) | 45-101 | Lost 4 |
| » W: Don Sutton (16-15) L: Clay Kirby (5-19) | Sixth | 36½ out |
| Monday, September 15 |
| » Defeated Astros (75-70), 5-3 | San Diego/Jack Murphy Stadium (24-48) | 46-101 | |
| » W: Mike Corkins (1-1) L: Don Wilson (16-12) S: Dave Roberts (1) | Sixth | 35½ out |
| Tuesday, September 16 |
| » Defeated Astros (75-71), 8-1 | San Diego/Jack Murphy Stadium (25-48) | 47-101 | Won 2 |
| » W: Tommie Sisk (2-11) L: Tom Griffin (10-8) | Sixth | 35 out |
| » Major-league debuts: Scipio Spinks (Astros) |
| Wednesday, September 17 |
| » Lost to Reds (80-67), 10-5 | San Diego/Jack Murphy Stadium (25-49) | 47-102 | |
| » W: Jack Fisher (4-4) L: Joe Niekro (8-16) S: George Culver (3) | Sixth | 35½ out |
| Thursday, September 18 |
| » Defeated Reds (80-68), 7-1 |