| Monday, January 6 |
| Future Indian Alvin Morman is born in Rockingham, NC. |
| Saturday, February 15 |
| Future Indian Brian Williams is born in Lancaster, SC. |
| Sunday, March 23 |
| Future Indian Chris Turner is born in Bowling Green, KY. Former Indian Oris Hockett dies in Torrance, CA at the age of 60. |
| Tuesday, March 25 |
| Future Indian Travis Fryman is born in Lexington, KY. |
| Monday, April 7 |
| » Major-league debuts: Bob Didier (Braves) |
| Tuesday, April 8 |
| » Lost to Tigers (1-0), 6-2 | Tiger Stadium (0-1) | 0-1 | |
| » W: Denny McLain (1-0) L: Luis Tiant (0-1) | Second | 1 out |
| Wednesday, April 9 |
| » Major-league debuts: Pedro Borbon (Angels) |
| Thursday, April 10 |
| » Lost to Tigers (2-0), 12-3 | Tiger Stadium (0-2) | 0-2 | Lost 2 |
| » W: Mickey Lolich (1-0) L: Sam McDowell (0-1) | Fifth | 2 out |
| Friday, April 11 |
| » Lost to Red Sox (2-1), 2-1 | Cleveland Stadium (0-1) | 0-3 | Lost 3 |
| » W: Bill Landis (2-0) L: Jack Hamilton (0-1) S: Juan Pizarro (2) | Fifth | 2½ out |
| » Major-league debuts: Billy Conigliaro (Red Sox) |
| Saturday, April 12 |
| » Lost to Red Sox (3-1), 5-3 | Cleveland Stadium (0-2) | 0-4 | Lost 4 |
| » W: Bill Landis (3-0) L: Stan Williams (0-1) | Fourth | 3 out |
| Sunday, April 13 |
| » Lost to Red Sox (4-1), 3-1 | Cleveland Stadium (0-3) | 0-5 | Lost 5 |
| » W: Lee Stange (1-0) L: Luis Tiant (0-2) | Sixth | 4 out |
| Tuesday, April 15 |
| » Defeated Tigers (3-3), 3-2 | Cleveland Stadium (1-3) | 1-5 | |
| » W: Vicente Romo (1-0) L: Pat Dobson (0-1) | Sixth | 3½ out |
| Future Indian Jeromy Burnitz is born in Westminster, CA. |
| Wednesday, April 16 |
| » Lost to Tigers (4-3), 8-2 | Cleveland Stadium (1-4) | 1-6 | |
| » W: Denny McLain (2-1) L: Sonny Siebert (0-1) | Fifth | 4 out |
| Thursday, April 17 |
| » Lost to Tigers (5-3), 7-6 | Cleveland Stadium (1-5) | 1-7 | Lost 2 |
| » W: Mickey Lolich (2-0) L: Vicente Romo (1-1) S: Don McMahon (1) | Fifth | 5 out |
| Friday, April 18 |
| » Lost to Red Sox (6-4), 10-7 | Fenway Park (0-1) | 1-8 | Lost 3 |
| » W: Ray Culp (2-0) L: Luis Tiant (0-3) S: Bill Landis (1) | Sixth | 6 out |
| Sunday, April 20 |
| » Lost to Red Sox (7-4), 9-4 | Fenway Park (0-2) | 1-9 | Lost 4 |
| » W: Ray Jarvis (1-0) L: Steve Hargan (0-1) | Sixth | 6 out |
| Monday, April 21 |
| » Lost to Orioles (10-5), 11-0 | Memorial Stadium (0-1) | 1-10 | Lost 5 |
| » W: Jim Palmer (3-0) L: Sam McDowell (0-2) | Fifth | 7 out |
| Tuesday, April 22 |
| » Lost to Orioles (11-5), 3-2 | Memorial Stadium (0-2) | 1-11 | Lost 6 |
| » W: Tom Phoebus (3-0) L: Stan Williams (0-2) S: Pete Richert (1) | Sixth | 8 out |
| Thursday, April 24 |
| » Lost to Yankees (8-6), 11-3 | Cleveland Stadium (1-6) | 1-12 | Lost 7 |
| » W: Fritz Peterson (2-2) L: Luis Tiant (0-4) | Fourth | 9½ out |
| Friday, April 25 |
| » Lost to Senators (8-10), 10-3 | Cleveland Stadium (1-7) | 1-13 | Lost 8 |
| » W: Dick Bosman (2-1) L: Dick Ellsworth (0-1) | Fifth | 9½ out |
| Saturday, April 26 |
| » Lost to Senators (9-10), 8-1 | Cleveland Stadium (1-8) | 1-14 | Lost 9 |
| » W: Casey Cox (1-0) L: Sam McDowell (0-3) | Fifth | 9½ out |
| Sunday, April 27 |
| » Lost to Senators (10-10), 6-5 | Cleveland Stadium (1-9) | 1-15 | Lost 10 |
| » W: Dave Baldwin (1-0) L: Stan Williams (0-3) S: Dennis Higgins (6) | Sixth | 11 out |
| Wednesday, April 30 |
| » Defeated Yankees (11-10), 3-0 | Yankee Stadium (1-0) | 2-15 | |
| » W: Sam McDowell (1-3) L: Bill Burbach (1-1) | Sixth | 11 out |
| Thursday, May 1 |
| » Defeated Yankees (11-11), 6-2 | Yankee Stadium (2-0) | 3-15 | Won 2 |
| » W: Mike Paul (1-0) L: Steve Hamilton (0-1) | Fifth | 10 out |
| Friday, May 2 |
| » Lost to Senators (14-11), 5-0 | Robert F. Kennedy Stadium (0-1) | 3-16 | |
| » W: Dick Bosman (3-1) L: Luis Tiant (0-5) | Sixth | 11 out |
| » Major-league debuts: Jack Heidemann (Indians) |
| Saturday, May 3 |
| » Lost to Senators (15-11), 6-1 | Robert F. Kennedy Stadium (0-2) | 3-17 | Lost 2 |
| » W: Camilo Pascual (2-3) L: Steve Hargan (0-2) S: Dave Baldwin (2) | Sixth | 12 out |
| Sunday, May 4 |
| » Lost to Senators (16-11), 4-3 | Robert F. Kennedy Stadium (0-3) | 3-18 | Lost 3 |
| » W: Dennis Higgins (1-1) L: Jack Hamilton (0-2) | Sixth | 13½ out |
| Tuesday, May 6 |
| » Defeated Twins (16-8), 1-0 | Cleveland Stadium (2-9) | 4-18 | |
| » W: Sam McDowell (2-3) L: Dave Boswell (3-3) | Sixth | 12½ out |
| Wednesday, May 7 |
| » Lost to Twins (17-8), 10-3 | Cleveland Stadium (2-10) | 4-19 | |
| » W: Jim Kaat (2-0) L: Luis Tiant (0-6) | Sixth | 12½ out |
| Former Indian Ray Mack dies in Bucyrus, OH at the age of 53. |
| Saturday, May 10 |
| » Lost to White Sox (11-11), 4-0 | Cleveland Stadium (2-11) | 4-20 | Lost 2 |
| » W: Tommy John (3-0) L: Sam McDowell (2-4) S: Bob Locker (4) | Sixth | 13 out |
| Sunday, May 11 |
| » Lost to White Sox (12-11), 7-5 | Cleveland Stadium (2-12) | 4-21 | Lost 3 |
| » W: Bob Locker (2-1) L: Stan Williams (0-4) S: Dan Osinski (1) | Sixth | 14 out |
| Tuesday, May 13 |
| » Defeated Royals (15-15), 8-6 | Municipal Stadium (1-0) | 5-21 | |
| » W: Dick Ellsworth (1-1) L: Jim Rooker (0-2) S: Juan Pizarro (3) | Sixth | 13 out |
| Wednesday, May 14 |
| » Defeated Royals (15-16), 3-2 | Municipal Stadium (2-0) | 6-21 | Won 2 |
| » W: Horacio Pina (1-0) L: Moe Drabowsky (3-3) S: Jack Hamilton (1) | Sixth | 13 out |
| Thursday, May 15 |
| » Lost to Royals (16-16), 5-2 | Municipal Stadium (2-1) | 6-22 | |
| » W: Mike Hedlund (2-1) L: Luis Tiant (0-7) S: Moe Drabowsky (5) | Sixth | 14 out |
| Friday, May 16 |
| » Lost to Athletics (21-11), 3-0 | Cleveland Stadium (2-13) | 6-23 | Lost 2 |
| » W: Blue Moon Odom (7-1) L: Mike Paul (1-1) | Sixth | 15 out |
| Saturday, May 17 |
| » Defeated Athletics (21-12), 5-4 | Cleveland Stadium (3-13) | 7-23 | |
| » W: Stan Williams (1-4) L: Catfish Hunter (3-3) | Sixth | 15 out |
| Tuesday, May 20 |
| » Defeated Royals (16-20), 4-1 | Cleveland Stadium (4-13) | 8-23 | Won 2 |
| » W: Sam McDowell (3-4) L: Mike Hedlund (2-2) | Sixth | 14½ out |
| Wednesday, May 21 |
| » Lost to Royals (17-20), 4-0 | Cleveland Stadium (4-14) | 8-24 | |
| » W: Roger Nelson (3-3) L: Mike Paul (1-2) | Sixth | 15½ out |
| Thursday, May 22 |
| » Defeated Royals (17-21), 4-1 | Cleveland Stadium (5-14) | 9-24 | |
| » W: Horacio Pina (2-0) L: Dick Drago (2-2) S: Stan Williams (1) | Sixth | 15½ out |
| Friday, May 23 |
| » Defeated Pilots (17-21), 7-1 | Cleveland Stadium (6-14) | 10-24 | Won 2 |
| » W: Dick Ellsworth (2-1) L: Mike Marshall (3-5) | Sixth | 15½ out |
| Saturday, May 24 |
| » Lost to Pilots (18-21), 8-2 | Cleveland Stadium (6-15) | 10-25 | |
| » W: Fred Talbot (1-0) L: Sam McDowell (3-5) | Sixth | 16½ out |
| Sunday, May 25 |
| » Lost to Pilots (19-21), 3-2 | Cleveland Stadium (6-16) | 10-26 | Lost 2 |
| » W: Diego Segui (5-2) L: Stan Williams (1-5) S: Gary Bell (2) | Sixth | 17½ out |
| Tuesday, May 27 |
| » Lost to Angels (12-28), 2-1 | Anaheim Stadium (0-1) | 10-27 | Lost 3 |
| » W: Jim McGlothlin (4-3) L: Sam McDowell (3-6) S: Hoyt Wilhelm (8) | Sixth | 17½ out |
| Wednesday, May 28 |
| » Lost to Angels (13-28), 5-4 | Anaheim Stadium (0-2) | 10-28 | Lost 4 |
| » W: Rudy May (2-6) L: Stan Williams (1-6) | Sixth | 18½ out |
| » Major-league debuts: Ken Tatum (Angels) |
| Former Indian Gus Getz dies in Red Bank, NJ at the age of 80. |
| Friday, May 30 |
| » Defeated Athletics (22-20), 9-2 | Oakland-Alameda County Stadium (1-0) | 11-28 | |
| » W: Luis Tiant (1-7) L: Rollie Fingers (3-3) S: Horacio Pina (1) | Sixth | 19 out |
| » Lost to Athletics (23-20), 5-1 | Oakland-Alameda County Stadium (1-1) | 11-29 | |
| » W: George Lauzerique (1-0) L: Mike Paul (1-3) | Sixth | 19 out |
| Saturday, May 31 |
| » Defeated Athletics (23-21), 5-2 | Oakland-Alameda County Stadium (2-1) | 12-29 | |
| » W: Sam McDowell (4-6) L: Jim Nash (3-3) S: Juan Pizarro (4) | Sixth | 18 out |
| Sunday, June 1 |
| » Lost to Athletics (24-21), 11-1 | Oakland-Alameda County Stadium (2-2) | 12-30 | |
| » W: Chuck Dobson (5-4) L: Dick Ellsworth (2-2) | Sixth | 19 out |
| Monday, June 2 |
| » Lost to Pilots (22-24), 8-2 | Sick's Stadium (0-1) | 12-31 | Lost 2 |
| » W: Steve Barber (2-1) L: Horacio Pina (2-1) S: Jim Bouton (1) | Sixth | 19½ out |
| Tuesday, June 3 |
| » Defeated Pilots (22-25), 3-1 | Sick's Stadium (1-1) | 13-31 | |
| » W: Luis Tiant (2-7) L: Marty Pattin (5-4) S: Stan Williams (2) | Sixth | 19½ out |
| Wednesday, June 4 |
| » Defeated Pilots (22-26), 10-4 | Sick's Stadium (2-1) | 14-31 | Won 2 |
| » W: Sam McDowell (5-6) L: Mike Marshall (3-7) S: Stan Williams (3) | Sixth | 19½ out |
| Friday, June 6 |
| » Defeated Angels (16-32), 8-3 | Cleveland Stadium (7-16) | 15-31 | Won 3 |
| » W: Juan Pizarro (1-1) L: Jim McGlothlin (4-4) | Sixth | 19½ out |
| Saturday, June 7 |
| » Defeated Angels (16-33), 7-0 | Cleveland Stadium (8-16) | 16-31 | Won 4 |
| » W: Luis Tiant (3-7) L: Tom Murphy (4-3) | Sixth | 19½ out |
| Sunday, June 8 |
| » Defeated Angels (16-34), 3-0 | Cleveland Stadium (9-16) | 17-31 | Won 5 |
| » W: Sam McDowell (6-6) L: George Brunet (1-5) | Sixth | 19 out |
| » Lost to Angels (17-34), 3-2 | Cleveland Stadium (9-17) | 17-32 | |
| » W: Jim McGlothlin (5-4) L: Mike Paul (1-4) S: Hoyt Wilhelm (9) | Sixth | 19 out |
| Monday, June 9 |
| » Defeated White Sox (21-28), 5-1 | Comiskey Park I (1-0) | 18-32 | |
| » W: Steve Hargan (1-2) L: Tommy John (4-4) S: Juan Pizarro (5) | Sixth | 18½ out |
| Tuesday, June 10 |
| » Lost to White Sox (22-28), 9-5 | Comiskey Park I (1-1) | 18-33 | |
| » W: Cisco Carlos (3-2) L: Mike Paul (1-5) S: Wilbur Wood (3) | Sixth | 19½ out |
| Wednesday, June 11 |
| » Lost to White Sox (23-28), 4-3 | County Stadium (0-1) | 18-34 | Lost 2 |
| » W: Dan Osinski (2-0) L: Luis Tiant (3-8) S: Wilbur Wood (4) | Sixth | 19½ out |
| Thursday, June 12 |
| Former Indian Joe Engel dies in Chattanooga, TN at the age of 77. |
| Friday, June 13 |
| » Defeated Twins (30-25), 6-4 | Metropolitan Stadium (1-0) | 19-34 | |
| » W: Sam McDowell (7-6) L: Jim Perry (4-3) | Sixth | 19½ out |
| Saturday, June 14 |
| » Defeated Twins (30-26), 12-0 | Metropolitan Stadium (2-0) | 20-34 | Won 2 |
| » W: Dick Ellsworth (3-2) L: Jim Kaat (6-5) | Sixth | 19½ out |
| Sunday, June 15 |
| » Lost to Twins (31-26), 3-2 | Metropolitan Stadium (2-1) | 20-35 | |
| » W: Dave Boswell (8-7) L: Steve Hargan (1-3) | Sixth | 21 out |
| Monday, June 16 |
| » Lost to Red Sox (37-22), 8-5 | Cleveland Stadium (9-18) | 20-36 | Lost 2 |
| » W: Lee Stange (2-4) L: Juan Pizarro (1-2) | Sixth | 21½ out |
| Tuesday, June 17 |
| » Defeated Red Sox (37-23), 4-2 | Cleveland Stadium (10-18) | 21-36 | |
| » W: Stan Williams (2-6) L: Jim Lonborg (6-2) | Sixth | 21½ out |
| Wednesday, June 18 |
| » Defeated Red Sox (37-24), 2-1 | Cleveland Stadium (11-18) | 22-36 | Won 2 |
| » W: Sam McDowell (8-6) L: Ray Jarvis (3-3) | Sixth | 21½ out |
| Thursday, June 19 |
| » Lost to Red Sox (38-24), 3-0 | Cleveland Stadium (11-19) | 22-37 | |
| » W: Ray Culp (10-4) L: Dick Ellsworth (3-3) | Sixth | 22½ out |
| Friday, June 20 |
| » Defeated Orioles (47-18), 7-2 | Cleveland Stadium (12-19) | 23-37 | |
| » W: Luis Tiant (4-8) L: Tom Phoebus (7-2) | Fifth | 22½ out |
| » Lost to Orioles (48-18), 5-1 | Cleveland Stadium (12-20) | 23-38 | |
| » W: Marcelino Lopez (3-1) L: Steve Hargan (1-4) S: Eddie Watt (7) | Fifth | 22½ out |
| Saturday, June 21 |
| » Lost to Orioles (49-18), 3-1 | Cleveland Stadium (12-21) | 23-39 | Lost 2 |
| » W: Mike Cuellar (8-5) L: Stan Williams (2-7) | Sixth | 23½ out |
| Sunday, June 22 |
| » Defeated Orioles (49-19), 3-2 | Cleveland Stadium (13-21) | 24-39 | |
| » W: Sam McDowell (9-6) L: Dick Hall (3-2) | Fifth | 23½ out |
| » Lost to Orioles (50-19), 6-0 | Cleveland Stadium (13-22) | 24-40 | |
| » W: Dave Leonhard (5-0) L: Horacio Pina (2-2) | Fifth | 23½ out |
| Tuesday, June 24 |
| » Defeated Red Sox (39-27), 6-3 | Fenway Park (1-2) | 25-40 | |
| » W: Luis Tiant (5-8) L: Ray Culp (10-5) | Fifth | 24½ out |
| » Lost to Red Sox (40-27), 6-1 | Fenway Park (1-3) | 25-41 | |
| » W: Lee Stange (3-4) L: Dick Ellsworth (3-4) | Fifth | 24½ out |
| Wednesday, June 25 |
| » Lost to Red Sox (41-27), 3-1 | Fenway Park (1-4) | 25-42 | Lost 2 |
| » W: Sonny Siebert (6-6) L: Steve Hargan (1-5) | Sixth | 24 out |
| » Defeated Red Sox (41-28), 7-3 | Fenway Park (2-4) | 26-42 | |
| » W: Stan Williams (3-7) L: Mike Nagy (3-1) | Sixth | 24 out |
| » Major-league debuts: Bill Lee (Red Sox) |
| Thursday, June 26 |
| » Lost to Red Sox (42-28), 4-3 | Fenway Park (2-5) | 26-43 | |
| » W: Vicente Romo (3-4) L: Larry Burchart (0-1) | Sixth | 24½ out |
| Friday, June 27 |
| » Defeated Yankees (35-40), 5-1 | Cleveland Stadium (14-22) | 27-43 | |
| » W: Sam McDowell (10-6) L: Lindy McDaniel (3-4) | Sixth | 24½ out |
| Saturday, June 28 |
| » Defeated Yankees (35-41), 7-3 | Cleveland Stadium (15-22) | 28-43 | Won 2 |
| » W: Dick Ellsworth (4-4) L: Bill Burbach (4-5) S: Stan Williams (4) | Sixth | 24½ out |
| Sunday, June 29 |
| » Defeated Yankees (35-42), 5-1 | Cleveland Stadium (16-22) | 29-43 | Won 3 |
| » W: Luis Tiant (6-8) L: Fritz Peterson (8-9) | Sixth | 24½ out |
| » Lost to Yankees (36-42), 6-3 | Cleveland Stadium (16-23) | 29-44 | |
| » W: Bill Burbach (5-5) L: Mike Paul (1-6) S: Jack Aker (5) | Sixth | 24½ out |
| Tuesday, July 1 |
| » Lost to Senators (39-39), 4-1 | Cleveland Stadium (16-24) | 29-45 | Lost 2 |
| » W: Casey Cox (5-1) L: Steve Hargan (1-6) | Sixth | 25 out |
| » Lost to Senators (40-39), 7-5 | Cleveland Stadium (16-25) | 29-46 | Lost 3 |
| » W: Dennis Higgins (7-7) L: Mike Paul (1-7) S: Darold Knowles (3) | Sixth | 25 out |
| Wednesday, July 2 |
| » Lost to Senators (41-39), 5-1 | Cleveland Stadium (16-26) | 29-47 | Lost 4 |
| » W: Dick Bosman (5-2) L: Sam McDowell (10-7) S: Darold Knowles (4) | Sixth | 25 out |
| Thursday, July 3 |
| » Defeated Senators (41-40), 7-2 | Cleveland Stadium (17-26) | 30-47 | |
| » W: Luis Tiant (7-8) L: Camilo Pascual (2-5) | Sixth | 24½ out |
| Friday, July 4 |
| » Lost to Yankees (39-42), 5-4 | Yankee Stadium (2-1) | 30-48 | |
| » W: Fritz Peterson (9-9) L: Dick Ellsworth (4-5) S: Jack Aker (6) | Sixth | 24 out |
| » Defeated Yankees (39-43), 4-1 | Yankee Stadium (3-1) | 31-48 | |
| » W: Juan Pizarro (2-2) L: Bill Burbach (5-6) | Sixth | 24 out |
| Saturday, July 5 |
| » Defeated Yankees (39-44), 4-2 | Yankee Stadium (4-1) | 32-48 | Won 2 |
| » W: Steve Hargan (2-6) L: Stan Bahnsen (4-10) S: Mike Paul (1) | Sixth | 24 out |
| Sunday, July 6 |
| » Lost to Yankees (40-44), 4-2 | Yankee Stadium (4-2) | 32-49 | |
| » W: Mel Stottlemyre (12-6) L: Sam McDowell (10-8) | Sixth | 24 out |
| Monday, July 7 |
| » Lost to Senators (45-42), 7-2 | Robert F. Kennedy Stadium (0-4) | 32-50 | Lost 2 |
| » W: Casey Cox (6-1) L: Luis Tiant (7-9) | Sixth | 24½ out |
| Tuesday, July 8 |
| » Defeated Senators (45-43), 6-5 | Robert F. Kennedy Stadium (1-4) | 33-50 | |
| » W: Horacio Pina (3-2) L: Dennis Higgins (7-8) S: Stan Williams (5) | Sixth | 25 out |
| Wednesday, July 9 |
| » Lost to Senators (46-43), 3-0 | Robert F. Kennedy Stadium (1-5) | 33-51 | |
| » W: Joe Coleman (5-7) L: Steve Hargan (2-7) | Sixth | 26 out |
| Thursday, July 10 |
| » Defeated Tigers (45-36), 7-5 | Tiger Stadium (1-2) | 34-51 | |
| » W: Mike Paul (2-7) L: Tom Timmermann (0-1) S: Stan Williams (6) | Sixth | 26 out |
| Future Indian Marty Cordova is born in Las Vegas, NV. |
| Friday, July 11 |
| » Defeated Tigers (45-37), 8-1 | Tiger Stadium (2-2) | 35-51 | Won 2 |
| » W: Sam McDowell (11-8) L: Joe Sparma (5-6) | Sixth | 24½ out |
| Saturday, July 12 |
| » Lost to Tigers (46-37), 15-3 | Tiger Stadium (2-3) | 35-52 | |
| » W: Mickey Lolich (12-2) L: Luis Tiant (7-10) | Sixth | 25½ out |
| Sunday, July 13 |
| » Lost to Tigers (47-37), 6-1 | Tiger Stadium (2-4) | 35-53 | Lost 2 |
| » W: Earl Wilson (7-7) L: Steve Hargan (2-8) | Sixth | 26 out |
| » Defeated Tigers (47-38), 9-4 | Tiger Stadium (3-4) | 36-53 | |
| » W: Luis Tiant (8-10) L: Pat Dobson (4-7) S: Juan Pizarro (6) | Sixth | 26 out |
| Tuesday, July 15 |
| » Lost to Orioles (63-27), 5-1 | Memorial Stadium (0-3) | 36-54 | |
| » W: Tom Phoebus (9-2) L: Sam McDowell (11-9) | Sixth | 27 out |
| Wednesday, July 16 |
| » Defeated Orioles (63-28), 6-4 | Memorial Stadium (1-3) | 37-54 | |
| » W: Dick Ellsworth (5-5) L: Mike Cuellar (10-8) S: Mike Paul (2) | Sixth | 27 out |
| » Lost to Orioles (64-28), 6-5 | Memorial Stadium (1-4) | 37-55 | |
| » W: Pete Richert (4-3) L: Stan Williams (3-8) | Sixth | 27 out |
| Thursday, July 17 |
| » Lost to Orioles (65-28), 3-2 | Memorial Stadium (1-5) | 37-56 | Lost 2 |
| » W: Pete Richert (5-3) L: Stan Williams (3-9) | Sixth | 28 out |
| Friday, July 18 |
| » Lost to Tigers (50-40), 4-0 | Cleveland Stadium (17-27) | 37-57 | Lost 3 |
| » W: Denny McLain (14-5) L: Luis Tiant (8-11) | Sixth | 28 out |
| Saturday, July 19 |
| » Lost to Tigers (51-40), 10-4 | Cleveland Stadium (17-28) | 37-58 | Lost 4 |
| » W: Don McMahon (2-5) L: Larry Burchart (0-2) | Sixth | 28 out |
| Sunday, July 20 |
| » Lost to Tigers (52-40), 3-2 | Cleveland Stadium (17-29) | 37-59 | Lost 5 |
| » W: Fred Lasher (1-0) L: Stan Williams (3-10) S: Don McMahon (9) | Sixth | 27½ out |
| » Defeated Tigers (52-41), 5-4 | Cleveland Stadium (18-29) | 38-59 | |
| » W: Horacio Pina (4-2) L: Joe Sparma (5-8) | Sixth | 27½ out |
| Thursday, July 24 |
| » Defeated Twins (59-38), 6-5 | Cleveland Stadium (19-29) | 39-59 | Won 2 |
| » W: Ron Law (1-0) L: Bob Miller (2-3) | Sixth | 27½ out |
| Friday, July 25 |
| » Lost to Twins (60-38), 4-2 | Cleveland Stadium (19-30) | 39-60 | |
| » W: Ron Perranoski (6-5) L: Mike Paul (2-8) | Sixth | 28½ out |
| Saturday, July 26 |
| » Defeated Twins (60-39), 6-3 | Cleveland Stadium (20-30) | 40-60 | |
| » W: Dick Ellsworth (6-5) L: Bob Miller (2-4) S: Stan Williams (7) | Sixth | 28½ out |
| Sunday, July 27 |
| » Lost to Twins (61-39), 8-7 | Cleveland Stadium (20-31) | 40-61 | |
| » W: Jerry Crider (1-0) L: Ron Law (1-1) S: Ron Perranoski (19) | Sixth | 29½ out |
| » Major-league debuts: Frank Baker (Indians) |
| Tuesday, July 29 |
| » Defeated White Sox (40-61), 4-3 | Cleveland Stadium (21-31) | 41-61 | |
| » W: Ron Law (2-1) L: Cisco Carlos (4-3) | Sixth | 29 out |
| » Defeated White Sox (40-62), 9-5 | Cleveland Stadium (22-31) | 42-61 | Won 2 |
| » W: Steve Hargan (3-8) L: Jack Hamilton (0-3) S: Stan Williams (8) | Sixth | 29 out |
| Wednesday, July 30 |
| » Lost to White Sox (41-62), 11-6 | Cleveland Stadium (22-32) | 42-62 | |
| » W: Joe Horlen (7-12) L: Sam McDowell (11-10) S: Wilbur Wood (7) | Sixth | 30 out |
| Thursday, July 31 |
| » Defeated White Sox (41-63), 3-2 | Cleveland Stadium (23-32) | 43-62 | |
| » W: Mike Paul (3-8) L: Jack Hamilton (0-4) | Sixth | 30 out |
| Friday, August 1 |
| » Lost to Royals (43-61), 6-0 | Municipal Stadium (2-2) | 43-63 | |
| » W: Dick Drago (5-9) L: Gary Boyd (0-1) | Sixth | 30 out |
| Saturday, August 2 |
| » Defeated Royals (43-62), 6-4 | Municipal Stadium (3-2) | 44-63 | |
| » W: Stan Williams (4-10) L: Tom Burgmeier (3-1) S: Sam McDowell (1) | Sixth | 30 out |
| Sunday, August 3 |
| » Lost to Royals (44-62), 3-2 | Municipal Stadium (3-3) | 44-64 | |
| » W: Wally Bunker (6-8) L: Luis Tiant (8-12) | Sixth | 30 out |
| Monday, August 4 |
| » Defeated Orioles (73-34), 2-0 | Cleveland Stadium (24-32) | 45-64 | |
| » W: Steve Hargan (4-8) L: Tom Phoebus (11-4) | Sixth | 29 out |
| Tuesday, August 5 |
| » Lost to Athletics (62-42), 8-3 | Cleveland Stadium (24-33) | 45-65 | |
| » W: Chuck Dobson (13-7) L: Dick Ellsworth (6-6) S: Paul Lindblad (5) | Sixth | 29½ out |
| » Defeated Athletics (62-43), 10-4 | Cleveland Stadium (25-33) | 46-65 | |
| » W: Sam McDowell (12-10) L: Blue Moon Odom (14-5) | Sixth | 29½ out |
| Wednesday, August 6 |
| » Lost to Athletics (63-43), 6-4 | Cleveland Stadium (25-34) | 46-66 | |
| » W: Paul Lindblad (6-2) L: Juan Pizarro (2-3) S: Marcel Lachemann (1) | Sixth | 30½ out |
| Thursday, August 7 |
| » Lost to Athletics (64-43), 3-0 | Cleveland Stadium (25-35) | 46-67 | Lost 2 |
| » W: George Lauzerique (3-1) L: Luis Tiant (8-13) S: Rollie Fingers (11) | Sixth | 31½ out |
| Friday, August 8 |
| » Defeated Royals (44-66), 7-4 | Cleveland Stadium (26-35) | 47-67 | |
| » W: Mike Paul (4-8) L: Wally Bunker (6-9) S: Stan Williams (9) | Sixth | 31½ out |
| Saturday, August 9 |
| » Lost to Royals (45-66), 10-0 | Cleveland Stadium (26-36) | 47-68 | |
| » W: Bill Butler (6-6) L: Steve Hargan (4-9) | Sixth | 32½ out |
| » Major-league debuts: Lou Camilli (Indians) |
| Former Indian Glenn Myatt dies in Houston, TX at the age of 73. |
| Sunday, August 10 |
| » Defeated Royals (45-67), 8-1 | Cleveland Stadium (27-36) | 48-68 | |
| » W: Sam McDowell (13-10) L: Chris Zachary (0-1) | Sixth | 32½ out |
| Monday, August 11 |
| » Lost to Pilots (47-65), 8-2 | Cleveland Stadium (27-37) | 48-69 | |
| » W: Diego Segui (9-4) L: Luis Tiant (8-14) | Sixth | 32½ out |
| Tuesday, August 12 |
| » Defeated Pilots (47-66), 6-5 | Cleveland Stadium (28-37) | 49-69 | |
| » W: Mike Paul (5-8) L: Fred Talbot (5-5) S: Stan Williams (10) | Sixth | 32½ out |
| Wednesday, August 13 |
| » Lost to Pilots (48-66), 5-3 | Cleveland Stadium (28-38) | 49-70 | |
| » W: George Brunet (7-9) L: Steve Hargan (4-10) | Sixth | 33½ out |
| Friday, August 15 |
| » Defeated Angels (44-69), 2-1 | Anaheim Stadium (1-2) | 50-70 | |
| » W: Ron Law (3-1) L: Hoyt Wilhelm (2-7) | Sixth | 33½ out |
| Saturday, August 16 |
| » Lost to Angels (45-69), 4-0 | Anaheim Stadium (1-3) | 50-71 | |
| » W: Andy Messersmith (11-8) L: Luis Tiant (8-15) | Sixth | 34½ out |
| Sunday, August 17 |
| » Lost to Angels (46-69), 7-6 | Anaheim Stadium (1-4) | 50-72 | Lost 2 |
| » W: Hoyt Wilhelm (3-7) L: Juan Pizarro (2-4) S: Ken Tatum (9) | Sixth | 35½ out |
| Monday, August 18 |
| » Lost to Angels (47-69), 3-1 | Anaheim Stadium (1-5) | 50-73 | Lost 3 |
| » W: Tom Murphy (8-11) L: Ron Law (3-2) | Sixth | 36½ out |
| Tuesday, August 19 |
| » Defeated Athletics (68-50), 3-0 | Oakland-Alameda County Stadium (3-2) | 51-73 | |
| » W: Sam McDowell (14-10) L: Chuck Dobson (13-10) | Sixth | 36½ out |
| Wednesday, August 20 |
| » Lost to Athletics (69-50), 2-1 | Oakland-Alameda County Stadium (3-3) | 51-74 | |
| » W: Blue Moon Odom (15-5) L: Luis Tiant (8-16) | Sixth | 36½ out |
| Friday, August 22 |
| » Defeated Pilots (48-74), 9-8 | Sick's Stadium (3-1) | 52-74 | |
| » W: Steve Hargan (5-10) L: Fred Talbot (5-7) S: Stan Williams (11) | Sixth | 36 out |
| Saturday, August 23 |
| » Defeated Pilots (48-75), 7-3 | Sick's Stadium (4-1) | 53-74 | Won 2 |
| » W: Sam McDowell (15-10) L: Marty Pattin (7-11) | Sixth | 35 out |
| Sunday, August 24 |
| » Defeated Pilots (48-76), 6-5 | Sick's Stadium (5-1) | 54-74 | Won 3 |
| » W: Stan Williams (5-10) L: Fred Talbot (5-8) S: Ron Law (1) | Sixth | 33½ out |
| Tuesday, August 26 |
| » Lost to Angels (52-71), 8-4 | Cleveland Stadium (28-39) | 54-75 | |
| » W: Vern Geishert (1-0) L: Steve Hargan (5-11) S: Ken Tatum (12) | Sixth | 33½ out |
| » Major-league debuts: Vern Geishert (Angels) |
| Wednesday, August 27 |
| » Lost to Angels (53-71), 4-1 | Cleveland Stadium (28-40) | 54-76 | Lost 2 |
| » W: Hoyt Wilhelm (4-7) L: Sam McDowell (15-11) S: Ken Tatum (13) | Sixth | 34½ out |
| Friday, August 29 |
| » Lost to White Sox (50-78), 4-2 | Comiskey Park I (1-2) | 54-77 | Lost 3 |
| » W: Joe Horlen (10-14) L: Luis Tiant (8-17) | Sixth | 34½ out |
| Saturday, August 30 |
| » Lost to White Sox (51-78), 6-5 | Comiskey Park I (1-3) | 54-78 | Lost 4 |
| » W: Danny Murphy (1-0) L: Stan Williams (5-11) | Sixth | 35½ out |
| Sunday, August 31 |
| » Lost to White Sox (52-78), 7-6 | Comiskey Park I (1-4) | 54-79 | Lost 5 |
| » W: Dan Osinski (5-5) L: Ron Law (3-3) | Sixth | 36½ out |
| Monday, September 1 |
| » Lost to Twins (80-52), 7-5 | Metropolitan Stadium (2-2) | 54-80 | Lost 6 |
| » W: Dean Chance (5-2) L: Sam McDowell (15-12) S: Ron Perranoski (26) | Sixth | 37½ out |
| Tuesday, September 2 |
| » Lost to Twins (81-52), 5-2 | Metropolitan Stadium (2-3) | 54-81 | Lost 7 |
| » W: Tom Hall (8-4) L: Luis Tiant (8-18) S: Dick Woodson (1) | Sixth | 37½ out |
| » Major-league debuts: Phil Hennigan (Indians) |
| Wednesday, September 3 |
| » Lost to Twins (82-52), 7-1 | Metropolitan Stadium (2-4) | 54-82 | Lost 8 |
| » W: Dave Boswell (15-10) L: Steve Hargan (5-12) | Sixth | 38 out |
| Thursday, September 4 |
| » Major-league debuts: Terry Crowley (Orioles) |
| Friday, September 5 |
| » Defeated Yankees (67-68), 2-1 | Cleveland Stadium (29-40) | 55-82 | |
| » W: Sam McDowell (16-12) L: Mel Stottlemyre (18-12) | Sixth | 39 out |
| » Lost to Yankees (68-68), 2-0 | Cleveland Stadium (29-41) | 55-83 | |
| » W: Fritz Peterson (15-13) L: Dick Ellsworth (6-7) | Sixth | 39 out |
| Saturday, September 6 |
| » Lost to Yankees (69-68), 1-0 | Cleveland Stadium (29-42) | 55-84 | Lost 2 |
| » W: Stan Bahnsen (9-13) L: Mike Paul (5-9) S: Jack Aker (12) | Sixth | 39 out |
| Sunday, September 7 |
| » Defeated Yankees (69-69), 7-3 | Cleveland Stadium (30-42) | 56-84 | |
| » W: Juan Pizarro (3-4) L: Lindy McDaniel (4-6) S: Stan Williams (12) | Sixth | 39 out |
| Monday, September 8 |
| » Lost to Red Sox (75-63), 5-4 | Cleveland Stadium (30-43) | 56-85 | |
| » W: Sonny Siebert (11-11) L: Phil Hennigan (0-1) | Sixth | 39½ out |
| Tuesday, September 9 |
| » Lost to Red Sox (76-63), 3-1 | Cleveland Stadium (30-44) | 56-86 | Lost 2 |
| » W: Vicente Romo (6-10) L: Sam McDowell (16-13) | Sixth | 41 out |
| Wednesday, September 10 |
| » Lost to Tigers (82-60), 4-1 | Cleveland Stadium (30-45) | 56-87 | Lost 3 |
| » W: Mickey Lolich (18-8) L: Dick Ellsworth (6-8) | Sixth | 42 out |
| Former Indian Jap Barbeau dies in Milwaukee, WI at the age of 88. |
| Thursday, September 11 |
| » Defeated Tigers (82-61), 5-2 | Cleveland Stadium (31-45) | 57-87 | |
| » W: Luis Tiant (9-18) L: Denny McLain (22-7) | Sixth | 42 out |
| Friday, September 12 |
| » Lost to Orioles (100-45), 2-1 | Memorial Stadium (1-6) | 57-88 | |
| » W: Jim Hardin (6-5) L: Stan Williams (5-12) S: Pete Richert (11) | Sixth | 43 out |
| Saturday, September 13 |
| » Lost to Orioles (101-45), 10-5 | Memorial Stadium (1-7) | 57-89 | Lost 2 |
| » W: Tom Phoebus (14-6) L: Steve Hargan (5-13) S: Dave Leonhard (1) | Sixth | 44 out |
| Sunday, September 14 |
| » Lost to Orioles (102-45), 7-3 | Memorial Stadium (1-8) | 57-90 | Lost 3 |
| » W: Mike Cuellar (22-10) L: Sam McDowell (16-14) | Sixth | 45 out |
| Former Indian Jackie Tavener dies in Fort Worth, TX at the age |