| Wednesday, January 1 |
| Future Cub Roberto Rivera is born in Bayamon, P.R. |
| Sunday, January 5 |
| Former Cub Tiny Osborne dies in Atlanta, GA at the age of 76. |
| Monday, January 6 |
| Former Cub Larry Cheney dies in Daytona Beach, FL at the age of 83. |
| Monday, January 13 |
| Future Cub Kevin Foster is born in Evanston, IL. |
| Thursday, January 23 |
| Former Cub Al Bridwell dies in Portsmouth, OH at the age of 86. |
| Saturday, February 15 |
| Future Cub Brian Williams is born in Lancaster, SC. |
| Sunday, February 23 |
| Former Cub Bubbles Hargrave dies in Cincinnati, OH at the age of 77. |
| Thursday, February 27 |
| Future Cub Willie Banks is born in Jersey City, NJ. |
| Saturday, March 1 |
| Future Cub Doug Creek is born in Winchester, VA. |
| Friday, March 14 |
| Former Cub Heinie Zimmerman dies in New York, NY at the age of 83. |
| Tuesday, March 25 |
| Future Cub Scott Sanders is born in Hannibal, MO. |
| Tuesday, April 8 |
| » Defeated Phillies (0-1), 7-6 | Wrigley Field (1-0) | 1-0 | |
| » W: Phil Regan (1-0) L: Barry Lersch (0-1) | First | -- |
| » Major-league debuts: Barry Lersch and Bill Wilson (Phillies) |
| Wednesday, April 9 |
| » Defeated Phillies (0-2), 11-3 | Wrigley Field (2-0) | 2-0 | Won 2 |
| » W: Bill Hands (1-0) L: Rick Wise (0-1) | First | -- |
| » Major-league debuts: Dave Watkins (Phillies) |
| Thursday, April 10 |
| » Defeated Phillies (0-3), 6-2 | Wrigley Field (3-0) | 3-0 | Won 3 |
| » W: Ken Holtzman (1-0) L: Woodie Fryman (0-1) | First | -- |
| » Major-league debuts: Jimmy Qualls (Cubs) |
| Friday, April 11 |
| » Defeated Expos (1-3), 1-0 | Wrigley Field (4-0) | 4-0 | Won 4 |
| » W: Ted Abernathy (1-0) L: Carroll Sembera (0-1) | First | -- |
| » Major-league debuts: Carl Morton (Expos) |
| Former Cub Al Kaiser dies in Cincinnati, OH at the age of 83. |
| Saturday, April 12 |
| » Lost to Expos (2-3), 7-3 | Wrigley Field (4-1) | 4-1 | |
| » W: Mudcat Grant (1-0) L: Fergie Jenkins (0-1) S: Carroll Sembera (2) | First | -- |
| Sunday, April 13 |
| » Defeated Expos (2-4), 7-6 | Wrigley Field (5-1) | 5-1 | |
| » W: Phil Regan (2-0) L: Bill Stoneman (0-2) | First | -- |
| Monday, April 14 |
| » Defeated Pirates (5-2), 4-0 | Wrigley Field (6-1) | 6-1 | Won 2 |
| » W: Ken Holtzman (2-0) L: Bob Veale (1-1) | First | -- |
| Tuesday, April 15 |
| » Defeated Pirates (5-3), 7-4 | Wrigley Field (7-1) | 7-1 | Won 3 |
| » W: Hank Aguirre (1-0) L: Dock Ellis (1-1) S: Ted Abernathy (1) | First | -- |
| Wednesday, April 16 |
| » Defeated Cardinals (4-5), 1-0 | Busch Stadium II (1-0) | 8-1 | Won 4 |
| » W: Fergie Jenkins (1-1) L: Steve Carlton (1-1) | First | -- |
| Thursday, April 17 |
| » Defeated Cardinals (4-6), 3-0 | Busch Stadium II (2-0) | 9-1 | Won 5 |
| » W: Bill Hands (2-0) L: Dave Giusti (1-1) S: Phil Regan (1) | First | -- |
| Saturday, April 19 |
| » Defeated Expos (4-6), 6-5 | Parc Jarry (1-0) | 10-1 | Won 6 |
| » W: Phil Regan (3-0) L: Don Shaw (1-2) | First | -- |
| Former Cub Rip Collins dies in Pittsburgh, PA at the age of 60. |
| Sunday, April 20 |
| » Defeated Expos (4-7), 6-3 | Parc Jarry (2-0) | 11-1 | Won 7 |
| » W: Fergie Jenkins (2-1) L: Carl Morton (0-1) | First | -- |
| » Lost to Expos (5-7), 4-2 | Parc Jarry (2-1) | 11-2 | |
| » W: Mike Wegener (1-0) L: Joe Niekro (0-1) S: Dan McGinn (1) | First | -- |
| » Major-league debuts: Ken Rudolph (Cubs) |
| Monday, April 21 |
| » Major-league debuts: Mike Nagy (Red Sox) |
| Tuesday, April 22 |
| » Lost to Pirates (9-4), 7-5 | Forbes Field (0-1) | 11-3 | Lost 2 |
| » W: Chuck Hartenstein (1-0) L: Bill Hands (2-1) | First | -- |
| » Lost to Pirates (10-4), 6-5 | Forbes Field (0-2) | 11-4 | Lost 3 |
| » W: Bruce Dal Canton (2-0) L: Rich Nye (0-1) S: Ron Kline (2) | First | -- |
| Thursday, April 24 |
| » Lost to Cardinals (6-9), 3-2 | Wrigley Field (7-2) | 11-5 | Lost 4 |
| » W: Dave Giusti (2-1) L: Ken Holtzman (2-1) | First | -- |
| Friday, April 25 |
| » Defeated Mets (6-9), 3-1 | Shea Stadium (1-0) | 12-5 | |
| » W: Fergie Jenkins (3-1) L: Tom Seaver (1-2) | First | -- |
| Saturday, April 26 |
| » Defeated Mets (6-10), 9-3 | Shea Stadium (2-0) | 13-5 | Won 2 |
| » W: Bill Hands (3-1) L: Don Cardwell (0-3) | First | -- |
| Sunday, April 27 |
| » Defeated Mets (6-11), 8-6 | Shea Stadium (3-0) | 14-5 | Won 3 |
| » W: Phil Regan (4-0) L: Cal Koonce (0-2) | First | -- |
| » Lost to Mets (7-11), 3-0 | Shea Stadium (3-1) | 14-6 | |
| » W: Tug McGraw (2-0) L: Rich Nye (0-2) | First | -- |
| Former Cub Harry Taylor dies in Toledo, OH at the age of 62. |
| Monday, April 28 |
| » Defeated Phillies (7-10), 2-1 | Shibe Park (1-0) | 15-6 | |
| » W: Ted Abernathy (2-0) L: Rick Wise (2-2) | First | -- |
| Tuesday, April 29 |
| » Defeated Phillies (7-11), 10-0 | Shibe Park (2-0) | 16-6 | Won 2 |
| » W: Fergie Jenkins (4-1) L: Grant Jackson (2-2) | First | -- |
| Wednesday, April 30 |
| » Lost to Phillies (8-11), 3-1 | Shibe Park (2-1) | 16-7 | |
| » W: Woodie Fryman (3-1) L: Bill Hands (3-2) | First | -- |
| Friday, May 2 |
| » Defeated Mets (9-13), 6-4 | Wrigley Field (8-2) | 17-7 | |
| » W: Ken Holtzman (3-1) L: Gary Gentry (2-1) S: Phil Regan (2) | First | -- |
| Saturday, May 3 |
| » Defeated Mets (9-14), 3-2 | Wrigley Field (9-2) | 18-7 | Won 2 |
| » W: Phil Regan (5-0) L: Cal Koonce (0-3) S: Ted Abernathy (2) | First | -- |
| Sunday, May 4 |
| » Lost to Mets (10-14), 3-2 | Wrigley Field (9-3) | 18-8 | |
| » W: Tom Seaver (3-2) L: Bill Hands (3-3) | First | -- |
| » Lost to Mets (11-14), 3-2 | Wrigley Field (9-4) | 18-9 | Lost 2 |
| » W: Tug McGraw (3-0) L: Dick Selma (2-3) | First | -- |
| Tuesday, May 6 |
| » Defeated Dodgers (15-11), 7-1 | Wrigley Field (10-4) | 19-9 | |
| » W: Ken Holtzman (4-1) L: Don Sutton (3-3) | First | -- |
| Wednesday, May 7 |
| » Lost to Dodgers (16-11), 4-2 | Wrigley Field (10-5) | 19-10 | |
| » W: Jim Brewer (1-1) L: Fergie Jenkins (4-2) S: Al McBean (2) | First | -- |
| Former Cub Ray Mack dies in Bucyrus, OH at the age of 53. |
| Friday, May 9 |
| » Lost to Giants (17-11), 11-1 | Wrigley Field (10-6) | 19-11 | Lost 2 |
| » W: Bobby Bolin (2-2) L: Bill Hands (3-4) S: Joe Gibbon (2) | First | -- |
| Sunday, May 11 |
| » Defeated Giants (17-12), 8-0 | Wrigley Field (11-6) | 20-11 | |
| » W: Ken Holtzman (5-1) L: Ray Sadecki (2-4) | First | -- |
| Monday, May 12 |
| » Defeated Padres (15-19), 2-0 | Wrigley Field (12-6) | 21-11 | Won 2 |
| » W: Fergie Jenkins (5-2) L: Gary Ross (1-2) | First | -- |
| Tuesday, May 13 |
| » Defeated Padres (15-20), 19-0 | Wrigley Field (13-6) | 22-11 | Won 3 |
| » W: Dick Selma (3-3) L: Dick Kelley (2-3) | First | -- |
| Wednesday, May 14 |
| » Defeated Padres (15-21), 3-2 | Wrigley Field (14-6) | 23-11 | Won 4 |
| » W: Don Nottebart (1-0) L: Johnny Podres (3-3) | First | -- |
| Friday, May 16 |
| » Defeated Astros (13-24), 11-0 | Astrodome (1-0) | 24-11 | Won 5 |
| » W: Ken Holtzman (6-1) L: Larry Dierker (5-4) | First | -- |
| Saturday, May 17 |
| » Lost to Astros (14-24), 5-4 | Astrodome (1-1) | 24-12 | |
| » W: Don Wilson (3-4) L: Don Nottebart (1-1) S: Fred Gladding (5) | First | -- |
| Sunday, May 18 |
| » Lost to Astros (15-24), 6-5 | Astrodome (1-2) | 24-13 | Lost 2 |
| » W: Jim Ray (1-0) L: Phil Regan (5-1) S: Fred Gladding (6) | First | -- |
| Tuesday, May 20 |
| » Defeated Dodgers (21-14), 7-0 | Dodger Stadium (1-0) | 25-13 | |
| » W: Ken Holtzman (7-1) L: Don Sutton (4-4) | First | -- |
| Wednesday, May 21 |
| » Lost to Dodgers (22-14), 3-1 | Dodger Stadium (1-1) | 25-14 | |
| » W: Claude Osteen (6-2) L: Bill Hands (3-5) | First | -- |
| Thursday, May 22 |
| » Defeated Dodgers (22-15), 3-0 | Dodger Stadium (2-1) | 26-14 | |
| » W: Fergie Jenkins (6-2) L: Bill Singer (5-4) | First | -- |
| Friday, May 23 |
| » Defeated Padres (16-27), 6-0 | San Diego/Jack Murphy Stadium (1-0) | 27-14 | Won 2 |
| » W: Dick Selma (4-3) L: Gary Ross (1-4) | First | -- |
| Saturday, May 24 |
| » Defeated Padres (16-28), 7-5 | San Diego/Jack Murphy Stadium (2-0) | 28-14 | Won 3 |
| » W: Ted Abernathy (3-0) L: Dick Kelley (2-4) S: Phil Regan (3) | First | -- |
| » Major-league debuts: John Sipin (Padres) |
| Sunday, May 25 |
| » Lost to Padres (17-28), 10-2 | San Diego/Jack Murphy Stadium (2-1) | 28-15 | |
| » W: Johnny Podres (4-3) L: Rich Nye (0-3) | First | -- |
| » Defeated Padres (17-29), 1-0 | San Diego/Jack Murphy Stadium (3-1) | 29-15 | |
| » W: Ted Abernathy (4-0) L: Joe Niekro (1-3) | First | -- |
| » Major-league debuts: Sonny Ruberto (Padres) |
| Tuesday, May 27 |
| » Lost to Giants (24-19), 5-4 | Candlestick Park (0-1) | 29-16 | |
| » W: Frank Linzy (2-1) L: Phil Regan (5-2) S: Ron Herbel (1) | First | -- |
| Former Cub Lou Jackson dies in Tokyo, Japan at the age of 34. |
| Wednesday, May 28 |
| » Defeated Giants (24-20), 9-8 | Candlestick Park (1-1) | 30-16 | |
| » W: Ken Holtzman (8-1) L: Rich Robertson (1-1) S: Phil Regan (4) | First | -- |
| Friday, May 30 |
| » Defeated Braves (28-15), 2-0 | Wrigley Field (15-6) | 31-16 | Won 2 |
| » W: Bill Hands (4-5) L: Ron Reed (5-3) | First | -- |
| Saturday, May 31 |
| » Defeated Braves (28-16), 3-2 | Wrigley Field (16-6) | 32-16 | Won 3 |
| » W: Fergie Jenkins (7-2) L: Phil Niekro (7-4) | First | -- |
| Sunday, June 1 |
| » Defeated Braves (28-17), 13-4 | Wrigley Field (17-6) | 33-16 | Won 4 |
| » W: Dick Selma (5-3) L: Pat Jarvis (5-3) | First | -- |
| Tuesday, June 3 |
| » Defeated Astros (24-28), 4-2 | Wrigley Field (18-6) | 34-16 | Won 5 |
| » W: Bill Hands (5-5) L: Denny Lemaster (3-7) | First | -- |
| Wednesday, June 4 |
| » Defeated Astros (24-29), 5-4 | Wrigley Field (19-6) | 35-16 | Won 6 |
| » W: Fergie Jenkins (8-2) L: Tom Griffin (2-3) | First | -- |
| Friday, June 6 |
| » Defeated Reds (26-21), 14-8 | Wrigley Field (20-6) | 36-16 | Won 7 |
| » W: Ken Holtzman (9-1) L: Tony Cloninger (3-7) S: Phil Regan (5) | First | -- |
| Saturday, June 7 |
| » Tied Reds, 5-5 | Wrigley Field (20-6) | 36-16 | |
| » Starters: Jim Merritt vs Bill Hands | First | -- |
| Monday, June 9 |
| » Lost to Reds (27-21), 4-1 | Wrigley Field (20-7) | 36-17 | |
| » W: George Culver (4-4) L: Fergie Jenkins (8-3) S: Wayne Granger (6) | First | -- |
| Tuesday, June 10 |
| » Defeated Braves (32-21), 3-1 | Atlanta-Fulton County Stadium (1-0) | 37-17 | |
| » W: Ken Holtzman (10-1) L: Ron Reed (5-5) S: Phil Regan (6) | First | -- |
| Wednesday, June 11 |
| » Lost to Braves (33-21), 5-1 | Atlanta-Fulton County Stadium (1-1) | 37-18 | |
| » W: Phil Niekro (10-4) L: Bill Hands (5-6) | First | -- |
| Thursday, June 12 |
| » Defeated Braves (33-22), 12-6 | Atlanta-Fulton County Stadium (2-1) | 38-18 | |
| » W: Dick Selma (6-3) L: Garry Hill (0-1) S: Ted Abernathy (3) | First | -- |
| Friday, June 13 |
| » Defeated Reds (28-24), 14-8 | Crosley Field (1-0) | 39-18 | Won 2 |
| » W: Phil Regan (6-2) L: Jose Pena (1-1) S: Rich Nye (1) | First | -- |
| Saturday, June 14 |
| » Defeated Reds (28-25), 9-8 | Crosley Field (2-0) | 40-18 | Won 3 |
| » W: Phil Regan (7-2) L: Wayne Granger (1-2) S: Fergie Jenkins (1) | First | -- |
| Sunday, June 15 |
| » Lost to Reds (29-25), 7-6 | Crosley Field (2-1) | 40-19 | |
| » W: Clay Carroll (8-3) L: Phil Regan (7-3) | First | -- |
| » Game at Crosley Field interrupted in the 8th inning with the score of Cubs 5, Reds 4. Completed on September 02. |
| » Major-league debuts: Rick Bladt (Cubs) |
| Monday, June 16 |
| » Lost to Pirates (31-30), 9-8 | Forbes Field (0-3) | 40-20 | Lost 2 |
| » W: Bruce Dal Canton (4-0) L: Phil Regan (7-4) S: Steve Blass (1) | First | -- |
| Tuesday, June 17 |
| » Lost to Pirates (32-30), 1-0 | Forbes Field (0-4) | 40-21 | Lost 3 |
| » W: Bob Veale (4-7) L: Fergie Jenkins (8-4) S: Bruce Dal Canton (3) | First | -- |
| » Lost to Pirates (33-30), 4-3 | Forbes Field (0-5) | 40-22 | Lost 4 |
| » W: Steve Blass (7-3) L: Ted Abernathy (4-1) | First | -- |
| » Major-league debuts: Gene Garber (Pirates) |
| Wednesday, June 18 |
| » Lost to Pirates (34-30), 3-2 | Forbes Field (0-6) | 40-23 | Lost 5 |
| » W: Joe Gibbon (2-3) L: Phil Regan (7-5) | First | -- |
| » Major-league debuts: Jose Martinez (Pirates) |
| Friday, June 20 |
| » Defeated Expos (16-45), 2-0 | Wrigley Field (21-7) | 41-23 | |
| » W: Bill Hands (6-6) L: Jerry Robertson (1-4) | First | -- |
| Saturday, June 21 |
| » Lost to Expos (17-45), 3-2 | Wrigley Field (21-8) | 41-24 | |
| » W: Howie Reed (2-1) L: Fergie Jenkins (8-5) S: Don Shaw (1) | First | -- |
| Sunday, June 22 |
| » Defeated Expos (17-46), 7-6 | Wrigley Field (22-8) | 42-24 | |
| » W: Dick Selma (7-3) L: Don Shaw (1-5) | First | -- |
| » Lost to Expos (18-46), 5-4 | Wrigley Field (22-9) | 42-25 | |
| » W: Roy Face (4-1) L: Archie Reynolds (0-1) S: Dan McGinn (2) | First | -- |
| Monday, June 23 |
| » Defeated Pirates (36-33), 5-4 | Wrigley Field (23-9) | 43-25 | |
| » W: Phil Regan (8-5) L: Bruce Dal Canton (5-1) | First | -- |
| Tuesday, June 24 |
| » Defeated Pirates (36-34), 3-2 | Wrigley Field (24-9) | 44-25 | Won 2 |
| » W: Bill Hands (7-6) L: Jim Bunning (6-5) | First | -- |
| Wednesday, June 25 |
| » Defeated Pirates (36-35), 5-2 | Wrigley Field (25-9) | 45-25 | Won 3 |
| » W: Fergie Jenkins (9-5) L: Bob Veale (4-8) | First | -- |
| Future Cub Brad Woodall is born in Atlanta, GA. |
| Thursday, June 26 |
| » Defeated Pirates (36-36), 7-5 | Wrigley Field (26-9) | 46-25 | Won 4 |
| » W: Phil Regan (9-5) L: Bruce Dal Canton (5-2) | First | -- |
| Future Cub Rodney Myers is born in Rockford, IL. |
| Friday, June 27 |
| » Lost to Cardinals (35-37), 3-1 | Wrigley Field (26-10) | 46-26 | |
| » W: Steve Carlton (8-5) L: Ken Holtzman (10-2) | First | -- |
| Saturday, June 28 |
| » Defeated Cardinals (35-38), 3-1 | Wrigley Field (27-10) | 47-26 | |
| » W: Bill Hands (8-6) L: Dave Giusti (3-7) | First | -- |
| Sunday, June 29 |
| » Defeated Cardinals (35-39), 3-1 | Wrigley Field (28-10) | 48-26 | Won 2 |
| » W: Fergie Jenkins (10-5) L: Bob Gibson (10-5) | First | -- |
| » Defeated Cardinals (35-40), 12-1 | Wrigley Field (29-10) | 49-26 | Won 3 |
| » W: Dick Selma (8-3) L: Mudcat Grant (4-8) | First | -- |
| Monday, June 30 |
| » Lost to Expos (21-52), 5-2 | Parc Jarry (2-2) | 49-27 | |
| » W: Howie Reed (3-1) L: Dave Lemonds (0-1) S: Dan McGinn (3) | First | -- |
| » Major-league debuts: Dave Lemonds (Cubs) |
| Tuesday, July 1 |
| » Lost to Expos (22-52), 11-4 | Parc Jarry (2-3) | 49-28 | Lost 2 |
| » W: Steve Renko (1-1) L: Ken Holtzman (10-3) S: Roy Face (4) | First | -- |
| Wednesday, July 2 |
| » Defeated Expos (22-53), 4-2 | Parc Jarry (3-3) | 50-28 | |
| » W: Bill Hands (9-6) L: Bill Stoneman (4-11) | First | -- |
| Thursday, July 3 |
| » Defeated Expos (22-54), 8-4 | Parc Jarry (4-3) | 51-28 | Won 2 |
| » W: Dick Selma (9-3) L: Mike Wegener (3-6) S: Phil Regan (7) | First | -- |
| Friday, July 4 |
| » Defeated Cardinals (37-44), 3-1 | Busch Stadium II (3-0) | 52-28 | Won 3 |
| » W: Fergie Jenkins (11-5) L: Bob Gibson (10-6) | First | -- |
| Saturday, July 5 |
| » Lost to Cardinals (38-44), 5-1 | Busch Stadium II (3-1) | 52-29 | |
| » W: Nelson Briles (7-7) L: Ken Holtzman (10-4) | First | -- |
| Sunday, July 6 |
| » Lost to Cardinals (39-44), 4-2 | Busch Stadium II (3-2) | 52-30 | Lost 2 |
| » W: Steve Carlton (10-5) L: Bill Hands (9-7) S: Joe Hoerner (9) | First | -- |
| » Lost to Cardinals (40-44), 6-3 | Busch Stadium II (3-3) | 52-31 | Lost 3 |
| » W: Chuck Taylor (1-0) L: Rich Nye (0-4) | First | -- |
| Tuesday, July 8 |
| » Lost to Mets (46-34), 4-3 | Shea Stadium (3-2) | 52-32 | Lost 4 |
| » W: Jerry Koosman (6-5) L: Fergie Jenkins (11-6) | First | -- |
| Future Cub Bobby Ayala is born in Ventura, CA. |
| Wednesday, July 9 |
| » Lost to Mets (47-34), 4-0 | Shea Stadium (3-3) | 52-33 | Lost 5 |
| » W: Tom Seaver (14-3) L: Ken Holtzman (10-5) | First | -- |
| Thursday, July 10 |
| » Defeated Mets (47-35), 6-2 | Shea Stadium (4-3) | 53-33 | |
| » W: Bill Hands (10-7) L: Gary Gentry (8-7) | First | -- |
| Friday, July 11 |
| » Lost to Phillies (38-46), 7-5 | Wrigley Field (29-11) | 53-34 | |
| » W: John Boozer (1-0) L: Ted Abernathy (4-2) S: Bill Wilson (4) | First | -- |
| Saturday, July 12 |
| » Defeated Phillies (38-47), 7-4 | Wrigley Field (30-11) | 54-34 | |
| » W: Fergie Jenkins (12-6) L: Rick Wise (6-7) S: Phil Regan (8) | First | -- |
| Sunday, July 13 |
| » Defeated Phillies (38-48), 6-0 | Wrigley Field (31-11) | 55-34 | Won 2 |
| » W: Ken Holtzman (11-5) L: Woodie Fryman (8-6) | First | -- |
| » Defeated Phillies (38-49), 6-4 | Wrigley Field (32-11) | 56-34 | Won 3 |
| » W: Jim Colborn (1-0) L: Lowell Palmer (1-4) S: Rich Nye (3) | First | -- |
| » Major-league debuts: Jim Colborn (Cubs) |
| Monday, July 14 |
| » Defeated Mets (49-37), 1-0 | Wrigley Field (33-11) | 57-34 | Won 4 |
| » W: Bill Hands (11-7) L: Tom Seaver (14-4) S: Phil Regan (9) | First | -- |
| Future Cub Jose Hernandez is born in Rio Piedras, P.R. |
| Tuesday, July 15 |
| » Lost to Mets (50-37), 5-4 | Wrigley Field (33-12) | 57-35 | |
| » W: Gary Gentry (9-7) L: Dick Selma (9-4) S: Ron Taylor (8) | First | -- |
| Wednesday, July 16 |
| » Lost to Mets (51-37), 9-5 | Wrigley Field (33-13) | 57-36 | Lost 2 |
| » W: Cal Koonce (4-3) L: Fergie Jenkins (12-7) S: Ron Taylor (9) | First | -- |
| Friday, July 18 |
| » Defeated Phillies (38-53), 9-5 | Shibe Park (3-1) | 58-36 | |
| » W: Phil Regan (10-5) L: Bill Wilson (2-3) | First | -- |
| Saturday, July 19 |
| » Lost to Phillies (39-53), 5-3 | Shibe Park (3-2) | 58-37 | |
| » W: Rick Wise (7-8) L: Bill Hands (11-8) | First | -- |
| Sunday, July 20 |
| » Defeated Phillies (39-54), 1-0 | Shibe Park (4-2) | 59-37 | |
| » W: Fergie Jenkins (13-7) L: Grant Jackson (9-10) | First | -- |
| » Defeated Phillies (39-55), 6-1 | Shibe Park (5-2) | 60-37 | Won 2 |
| » W: Dick Selma (10-4) L: Bill Champion (3-5) | First | -- |
| Thursday, July 24 |
| » Defeated Dodgers (53-42), 5-3 | Wrigley Field (34-13) | 61-37 | Won 3 |
| » W: Ken Holtzman (12-5) L: Don Sutton (12-10) S: Phil Regan (10) | First | -- |
| Friday, July 25 |
| » Lost to Dodgers (54-42), 4-2 | Wrigley Field (34-14) | 61-38 | |
| » W: Claude Osteen (13-8) L: Fergie Jenkins (13-8) S: Jim Brewer (16) | First | -- |
| Saturday, July 26 |
| » Defeated Dodgers (54-43), 3-2 | Wrigley Field (35-14) | 62-38 | |
| » W: Phil Regan (11-5) L: Jim Brewer (3-4) | First | -- |
| Sunday, July 27 |
| » Lost to Dodgers (55-43), 6-2 | Wrigley Field (35-15) | 62-39 | |
| » W: Don Drysdale (5-3) L: Fergie Jenkins (13-9) S: Pete Mikkelsen (1) | First | -- |
| Monday, July 28 |
| » Defeated Giants (55-46), 4-3 | Wrigley Field (36-15) | 63-39 | |
| » W: Rich Nye (1-4) L: Juan Marichal (13-6) | First | -- |
| Tuesday, July 29 |
| » Lost to Giants (56-46), 4-2 | Wrigley Field (36-16) | 63-40 | |
| » W: Frank Linzy (9-6) L: Ted Abernathy (4-3) | First | -- |
| Wednesday, July 30 |
| » Lost to Giants (57-46), 6-3 | Wrigley Field (36-17) | 63-41 | Lost 2 |
| » W: Gaylord Perry (13-7) L: Rich Nye (1-5) | First | -- |
| Thursday, July 31 |
| » Defeated Giants (57-47), 12-2 | Wrigley Field (37-17) | 64-41 | |
| » W: Fergie Jenkins (14-9) L: Bobby Bolin (5-7) | First | -- |
| Friday, August 1 |
| » Defeated Padres (34-72), 5-2 | Wrigley Field (38-17) | 65-41 | Won 2 |
| » W: Bill Hands (12-8) L: Clay Kirby (3-14) S: Phil Regan (11) | First | -- |
| Saturday, August 2 |
| » Defeated Padres (34-73), 4-1 | Wrigley Field (39-17) | 66-41 | Won 3 |
| » W: Ken Holtzman (13-5) L: Al Santorini (4-10) | First | -- |
| Sunday, August 3 |
| » Defeated Padres (34-74), 4-3 | Wrigley Field (40-17) | 67-41 | Won 4 |
| » W: Dick Selma (11-4) L: Joe Niekro (6-8) S: Phil Regan (12) | First | -- |
| Monday, August 4 |
| » Defeated Astros (57-51), 9-3 | Astrodome (2-2) | 68-41 | Won 5 |
| » W: Fergie Jenkins (15-9) L: Tom Griffin (7-5) | First | -- |
| Tuesday, August 5 |
| » Defeated Astros (57-52), 5-2 | Astrodome (3-2) | 69-41 | Won 6 |
| » W: Bill Hands (13-8) L: Denny Lemaster (8-11) S: Phil Regan (13) | First | -- |
| Wednesday, August 6 |
| » Defeated Astros (57-53), 5-4 | Astrodome (4-2) | 70-41 | Won 7 |
| » W: Rich Nye (2-5) L: Jack Billingham (4-6) S: Dick Selma (1) | First | -- |
| Friday, August 8 |
| » Lost to Dodgers (60-50), 5-0 | Dodger Stadium (2-2) | 70-42 | |
| » W: Bill Singer (14-7) L: Fergie Jenkins (15-10) | First | -- |
| Saturday, August 9 |
| » Defeated Dodgers (60-51), 4-0 | Dodger Stadium (3-2) | 71-42 | |
| » W: Bill Hands (14-8) L: Alan Foster (3-7) | First | -- |
| Sunday, August 10 |
| » Lost to Dodgers (61-51), 4-2 | Dodger Stadium (3-3) | 71-43 | |
| » W: Don Sutton (14-11) L: Ken Holtzman (13-6) S: Pete Mikkelsen (2) | First | -- |
| Monday, August 11 |
| Former Cub Bill Marriott dies in Berkeley, CA at the age of 77. |
| Tuesday, August 12 |
| » Defeated Padres (35-80), 4-0 | San Diego/Jack Murphy Stadium (4-1) | 72-43 | |
| » W: Fergie Jenkins (16-10) L: Al Santorini (4-12) | First | -- |
| Wednesday, August 13 |
| » Defeated Padres (35-81), 4-2 | San Diego/Jack Murphy Stadium (5-1) | 73-43 | Won 2 |
| » W: Bill Hands (15-8) L: Joe Niekro (6-10) | First | -- |
| Friday, August 15 |
| » Lost to Giants (63-53), 3-0 | Candlestick Park (1-2) | 73-44 | |
| » W: Juan Marichal (14-8) L: Ken Holtzman (13-7) | First | -- |
| Saturday, August 16 |
| » Defeated Giants (63-54), 3-0 | Candlestick Park (2-2) | 74-44 | |
| » W: Fergie Jenkins (17-10) L: Gaylord Perry (15-9) | First | -- |
| Sunday, August 17 |
| » Lost to Giants (64-54), 5-3 | Candlestick Park (2-3) | 74-45 | |
| » W: Frank Linzy (10-6) L: Bill Hands (15-9) | First | -- |
| » Defeated Giants (64-55), 3-1 | Candlestick Park (3-3) | 75-45 | |
| » W: Dick Selma (12-4) L: Ron Bryant (2-1) S: Phil Regan (14) | First | -- |
| Tuesday, August 19 |
| » Defeated Braves (66-58), 3-0 | Wrigley Field (41-17) | 76-45 | Won 2 |
| » W: Ken Holtzman (14-7) L: Phil Niekro (16-11) | First | -- |
| Future Cub Matt Franco is born in Santa Monica, CA. Former Cub John Hollison dies in Chicago, IL at the age of 100 |
| Wednesday, August 20 |
| » Lost to Braves (67-58), 6-2 | Wrigley Field (41-18) | 76-46 | |
| » W: Ron Reed (12-8) L: Fergie Jenkins (17-11) | First | -- |
| Thursday, August 21 |
| » Lost to Braves (68-58), 3-1 | Wrigley Field (41-19) | 76-47 | Lost 2 |
| » W: Jim Britton (7-4) L: Bill Hands (15-10) | First | -- |
| Friday, August 22 |
| » Lost to Astros (65-57), 8-2 | Wrigley Field (41-20) | 76-48 | Lost 3 |
| » W: Larry Dierker (16-9) L: Dick Selma (12-5) | First | -- |
| Saturday, August 23 |
| » Defeated Astros (65-58), 11-5 | Wrigley Field (42-20) | 77-48 | |
| » W: Ken Holtzman (15-7) L: Fred Gladding (2-4) | First | -- |
| Sunday, August 24 |
| » Defeated Astros (65-59), 10-9 | Wrigley Field (43-20) | 78-48 | Won 2 |
| » W: Phil Regan (12-5) L: Fred Gladding (2-5) S: Hank Aguirre (1) | First | -- |
| » Lost to Astros (66-59), 3-2 | Wrigley Field (43-21) | 78-49 | |
| » W: Don Wilson (16-8) L: Ken Johnson (1-4) | First | -- |
| Monday, August 25 |
| » Lost to Reds (67-56), 9-8 | Wrigley Field (43-22) | 78-50 | Lost 2 |
| » W: Gary Nolan (4-5) L: Bill Hands (15-11) S: Pedro Ramos (2) | First | -- |
| Tuesday, August 26 |
| » Lost to Reds (68-56), 8-7 | Wrigley Field (43-23) | 78-51 | Lost 3 |
| » W: Jim Merritt (15-5) L: Dick Selma (12-6) S: Wayne Granger (17) | First | -- |
| Wednesday, August 27 |
| » Lost to Reds (69-56), 6-3 | Wrigley Field (43-24) | 78-52 | Lost 4 |
| » W: Tony Cloninger (9-14) L: Ken Holtzman (15-8) S: Clay Carroll (7) | First | -- |
| » Major-league debuts: Oscar Gamble (Cubs) |
| Thursday, August 28 |
| » Defeated Reds (69-57), 3-1 | Wrigley Field (44-24) | 79-52 | |
| » W: Fergie Jenkins (18-11) L: Gerry Arrigo (2-5) | First | -- |
| Friday, August 29 |
| » Defeated Braves (73-60), 2-1 | Atlanta-Fulton County Stadium (3-1) | 80-52 | Won 2 |
| » W: Bill Hands (16-11) L: Pat Jarvis (10-9) | First | -- |
| Saturday, August 30 |
| » Defeated Braves (73-61), 5-4 | Atlanta-Fulton County Stadium (4-1) | 81-52 | Won 3 |
| » W: Ken Johnson (2-4) L: Ron Reed (13-9) S: Phil Regan (15) | First | -- |
| Sunday, August 31 |
| » Defeated Braves (73-62), 8-4 | Atlanta-Fulton County Stadium (5-1) | 82-52 | Won 4 |
| » W: Ken Holtzman (16-8) L: Phil Niekro (18-12) S: Phil Regan (16) | First | -- |
| Monday, September 1 |
| » Major-league debuts: Miguel Fuentes (Pilots) |
| Tuesday, September 2 |
| » Defeated Reds (72-58), 8-2 | Crosley Field (3-1) | 83-52 | Won 5 |
| » W: Fergie Jenkins (19-11) L: Tony Cloninger (9-15) | First | -- |
| » Defeated Reds (72-59), 5-4 | Crosley Field (4-1) | 84-52 | Won 6 |
| » W: Rich Nye (3-5) L: Gerry Arrigo (2-6) S: Ken Johnson (2) | First | -- |
| » Major-league debuts: Bernie Carbo (Reds) |
| Wednesday, September 3 |
| » Lost to Reds (73-59), 2-0 | Crosley Field (4-2) | 84-53 | |
| » W: Jim Maloney (8-4) L: Bill Hands (16-12) | First | -- |
| Friday, September 5 |
| » Lost to Pirates (72-61), 9-2 | Wrigley Field (44-25) | 84-54 | Lost 2 |
| » W: Steve Blass (14-8) L: Ken Holtzman (16-9) | First | -- |
| Saturday, September 6 |
| » Lost to Pirates (73-61), 13-4 | Wrigley Field (44-26) | 84-55 | Lost 3 |
| » W: Bob Veale (11-11) L: Fergie Jenkins (19-12) | First | -- |
| Sunday, September 7 |
| » Lost to Pirates (74-61), 7-5 | Wrigley Field (44-27) | 84-56 | Lost 4 |
| » W: Bruce Dal Canton (8-2) L: Ken Johnson (2-5) | First | -- |
| Monday, September 8 |
| » Lost to Mets (81-57), 3-2 | Shea Stadium (4-4) | 84-57 | Lost 5 |
| » W: Jerry Koosman (13-9) L: Bill Hands (16-13) | First | -- |
| Tuesday, September 9 |
| » Lost to Mets (82-57), 7-1 | Shea Stadium (4-5) | 84-58 | Lost 6 |
| » W: Tom Seaver (21-7) L: Fergie Jenkins (19-13) | First | -- |
| Wednesday, September 10 |
| » Lost to Phillies (56-84), 6-2 | Shibe Park (5-3) | 84-59 | Lost 7 |
| » W: Rick Wise (13-11) L: Ken Holtzman (16-10) | Second | 1 out |
| Thursday, September 11 |
| » Lost to Phillies (57-84), 4-3 | Shibe Park (5-4) | 84-60 | Lost 8 |
| » W: Jeff James (1-0) L: Dick Selma (12-7) S: Grant Jackson (1) | Second | 2 out |
| Friday, September 12 |
| » Defeated Cardinals (77-67), 5-1 | Busch Stadium II (4-3) | 85-60 | |
| » W: Bill Hands (17-13) L: Chuck Taylor (7-3) | Second | 2½ out |
| Former Cub Ed Schorr dies in Atlantic City, NJ at the age of 79. |
| Saturday, September 13 |
| » Lost to Cardinals (78-67), 7-4 | Busch Stadium II (4-4) | 85-61 | |
| » W: Mudcat Grant (8-11) L: Fergie Jenkins (19-14) S: Joe Hoerner (15) | Second | 3½ out |
| Sunday, September 14 |
| » Lost to Cardinals (79-67), 2-1 | Busch Stadium II (4-5) | 85-62 | Lost 2 |
| » W: Bob Gibson (18-11) L: Ken Holtzman (16-11) | Second | 3½ out |
| Monday, September 15 |
| » Lost to Expos (48-100), 8-2 | Parc Jarry (4-4) | 85-63 | Lost 3 |
| » W: Mike Wegener (5-12) L: Dick Selma (12-8) | Second | 4½ out |
| Tuesday, September 16 |
| » Defeated Expos (48-101), 5-4 | Parc Jarry (5-4) | 86-63 | |
| » W: Bill Hands (18-13) L: Jerry Robertson (5-14) S: Phil Regan (17) | Second | 4 out |
| Wednesday, September 17 |
| » Defeated Phillies (59-89), 9-7 | Wrigley Field (45-27) | 87-63 | Won 2 |
| » W: Fergie Jenkins (20-14) L: Bill Champion (5-10) S: Rich Nye (4) | Second | 4 out |
| Thursday, September 18 |
| » Lost to Phillies (60-89), 5-3 | Wrigley Field (45-28) | 87-64 | |
| » W: Grant Jackson (13-16) L: Phil Regan (12-6) | Second | 5 out |
| » Major-league debuts: Joe Decker (Cubs) |
| Friday, September 19 |
| » Defeated Cardinals (80-70), 2-1 | Wrigley Field (46-28) | 88-64 | |
| » W: Ken Holtzman (17-11) L: Bob Gibson (18-12) | Second | 4 out |
| » Lost to Cardinals (81-70), 7-2 | Wrigley Field (46-29) | 88-65 | |
| » W: Mike Torrez (9-4) L: Dick Selma (12-9) | Second | 4 out |
| Saturday, September 20 |
| » Lost to Cardinals (82-70), 4-1 | Wrigley Field (46-30) | 88-66 | Lost 2 |
| » W: Steve Carlton (17-10) L: Bill Hands (18-14) S: Mudcat Grant (7) | Second | 4 out |
| Sunday, September 21 |
| » Defeated Cardinals (82-71), 4-3 | Wrigley Field (47-30) | 89-66 | |
| » W: Fergie Jenkins (21-14) L: Chuck Taylor (7-5) | Second | 4½ out |
| Monday, September 22 |
| » Major-league debuts: Mike Garman (Red Sox) |
| Tuesday, September 23 |
| » Lost to Expos (52-104), 7-3 | Wrigley Field (47-31) | 89-67 | |
| » W: Bill Stoneman (11-18) L: Ken Holtzman (17-12) | Second | 6 out |
| Wednesday, September 24 |
| » Defeated Expos (52-105), 6-3 | Wrigley Field (48-31) | 90-67 | |
| » W: Bill Hands (19-14) L: Steve Renko (6-7) | Second | 6 out |
| Thursday, September 25 |
| Future Cub David Weathers is born in Lawrenceburg, TN. |
| Friday, September 26 |
| » Lost to Pirates (85-73), 2-0 | Forbes Field (0-7) | 90-68 | |
| » W: Dock Ellis (11-17) L: Fergie Jenkins (21-15) | Second | 7 out |
| Saturday, September 27 |
| » Lost to Pirates (86-73), 4-1 | Forbes Field (0-8) | 90-69 | Lost 2 |
| » W: Steve Blass (16-10) L: Ken Holtzman (17-13) S: Bob Moose (4) | Second | 8 out |
| Sunday, September 28 |
| » Defeated Pirates (86-74), 3-1 | Forbes Field (1-8) | 91-69 | |
| » W: Bill Hands (20-14) L: Bob Veale (13-14) | Second | 8 out |
| Former Cub Norm McMillan dies in Marion, SC at the age of 74. |
| Monday, September 29 |
| Former Cub Tommy Leach dies in Haines City, FL at the age of 92. |
| Wednesday, October 1 |
| » Lost to Mets (100-61), 6-5 | Wrigley Field (48-32) | 91-70 | |
| » W: Ron Taylor (9-4) L: Dick Selma (12-10) S: Bob Johnson (1) | Second | 9 out |
| Thursday, October 2 |
| » Defeated Mets (100-62), 5-3 | Wrigley Field (49-32) | 92-70 | |
| » W: Joe Decker (1-0) L: Don Cardwell (8-10) | Second | 8 out |
| Future Cub Matt Walbeck is born in Sacramento, CA. |
| Wednesday, October 8 |
| Former Cub Willie Ramsdell dies in Wichita, KS at the age of 54. |
| Thursday, October 9 |
| Former Cub Don Hoak dies in Pittsburgh, PA at the age of 42. |
| Sunday, October 12 |
| Future Cub Derrick White is born in San Rafael, CA. |
| Monday, October 13 |
| Future Cub Damian Miller is born in LaCrosse, WI. |
| Sunday, October 19 |
| Future Cub Lance Dickson is born in Fullerton, CA. |
| Thursday, October 23 |
| Former Cub Monk Dubiel dies in Hartford, CT at the age of 52. |
| Thursday, November 6 |
| Future Cub Don Wengert is born in Sioux City, IA. |
| Sunday, November 16 |
| Former Cub Vin Campbell dies in Towson, MD at the age of 82. |
| Wednesday, November 26 |
| Former Cub Emil Kush dies in River Grove, IL at the age of 54. |
Game information provided by Retrosheet (www.retrosheet.org) |