| Wednesday, January 15 |
| Future Cardinal Delino DeShields is born in Seaford, DE. |
| Monday, January 27 |
| Future Cardinal Phil Plantier is born in Manchester, NH. |
| Monday, February 3 |
| Future Cardinal Terry Bradshaw is born in Franklin, VA. |
| Tuesday, February 11 |
| Future Cardinal Bryan Eversgerd is born in Centralia, IL. |
| Saturday, March 1 |
| Future Cardinal Doug Creek is born in Winchester, VA. |
| Thursday, March 20 |
| Former Cardinal Jim Clark dies in Beaumont, TX at the age of 82. |
| Friday, March 28 |
| Future Cardinal Craig Paquette is born in Long Beach, CA. |
| Monday, April 7 |
| » Major-league debuts: Bob Didier (Braves) |
| Tuesday, April 8 |
| » Lost to Pirates (1-0), 6-2 | Busch Stadium II (0-1) | 0-1 | |
| » W: Bruce Dal Canton (1-0) L: Mel Nelson (0-1) S: Chuck Hartenstein (1) | Second | 1 out |
| Wednesday, April 9 |
| » Lost to Pirates (2-0), 6-1 | Busch Stadium II (0-2) | 0-2 | Lost 2 |
| » W: Bob Veale (1-0) L: Nelson Briles (0-1) | Third | 2 out |
| Thursday, April 10 |
| » Lost to Pirates (3-0), 3-2 | Busch Stadium II (0-3) | 0-3 | Lost 3 |
| » W: Dock Ellis (1-0) L: Ray Washburn (0-1) | Fourth | 3 out |
| Friday, April 11 |
| » Defeated Mets (2-2), 6-5 | Shea Stadium (1-0) | 1-3 | |
| » W: Steve Carlton (1-0) L: Jerry Koosman (0-1) S: Joe Hoerner (1) | Third | 3 out |
| Saturday, April 12 |
| » Defeated Mets (2-3), 1-0 | Shea Stadium (2-0) | 2-3 | Won 2 |
| » W: Dave Giusti (1-0) L: Don Cardwell (0-1) | Second | 2 out |
| » Major-league debuts: Wayne Garrett (Mets) |
| Sunday, April 13 |
| » Defeated Mets (2-4), 3-1 | Shea Stadium (3-0) | 3-3 | Won 3 |
| » W: Bob Gibson (1-0) L: Tom Seaver (0-1) | Second | 2 out |
| Monday, April 14 |
| » Lost to Expos (3-4), 8-7 | Parc Jarry (0-1) | 3-4 | |
| » W: Dan McGinn (1-0) L: Gary Waslewski (0-1) | Third | 3 out |
| Tuesday, April 15 |
| » Defeated Expos (3-5), 4-3 | Parc Jarry (1-1) | 4-4 | |
| » W: Ray Washburn (1-1) L: Don Shaw (1-1) S: Joe Hoerner (2) | Third | 3 out |
| Wednesday, April 16 |
| » Lost to Cubs (8-1), 1-0 | Busch Stadium II (0-4) | 4-5 | |
| » W: Fergie Jenkins (1-1) L: Steve Carlton (1-1) | Third | 4 out |
| Future Cardinal Fernando Vina is born in Sacramento, CA. |
| Thursday, April 17 |
| » Lost to Cubs (9-1), 3-0 | Busch Stadium II (0-5) | 4-6 | Lost 2 |
| » W: Bill Hands (2-0) L: Dave Giusti (1-1) S: Phil Regan (1) | Fourth | 5 out |
| Saturday, April 19 |
| » Lost to Mets (4-7), 2-1 | Busch Stadium II (0-6) | 4-7 | Lost 3 |
| » W: Tom Seaver (1-1) L: Bob Gibson (1-1) | Fourth | 6 out |
| Sunday, April 20 |
| » Lost to Mets (5-7), 11-3 | Busch Stadium II (0-7) | 4-8 | Lost 4 |
| » W: Nolan Ryan (1-0) L: Nelson Briles (0-2) S: Cal Koonce (3) | Fourth | 6½ out |
| Monday, April 21 |
| » Defeated Expos (5-8), 5-4 | Busch Stadium II (1-7) | 5-8 | |
| » W: Ray Washburn (2-1) L: Don Shaw (1-3) | Third | 6 out |
| Tuesday, April 22 |
| » Lost to Expos (6-8), 2-0 | Busch Stadium II (1-8) | 5-9 | |
| » W: Bill Stoneman (2-2) L: Steve Carlton (1-2) | Fifth | 5½ out |
| Thursday, April 24 |
| » Defeated Cubs (11-5), 3-2 | Wrigley Field (1-0) | 6-9 | |
| » W: Dave Giusti (2-1) L: Ken Holtzman (2-1) | Fourth | 4½ out |
| Friday, April 25 |
| » Lost to Phillies (6-8), 5-1 | Shibe Park (0-1) | 6-10 | |
| » W: Grant Jackson (2-1) L: Bob Gibson (1-2) | Fifth | 5½ out |
| Saturday, April 26 |
| » Defeated Phillies (6-9), 10-4 | Shibe Park (1-1) | 7-10 | |
| » W: Ron Willis (1-0) L: Barry Lersch (0-2) S: Joe Hoerner (3) | Third | 5½ out |
| Sunday, April 27 |
| » Lost to Phillies (7-9), 1-0 | Shibe Park (1-2) | 7-11 | |
| » W: Jerry Johnson (1-2) L: Ray Washburn (2-2) | Fourth | 6 out |
| Monday, April 28 |
| » Defeated Pirates (12-7), 6-2 | Forbes Field (1-0) | 8-11 | |
| » W: Steve Carlton (2-2) L: Bob Moose (2-1) | Third | 6 out |
| Wednesday, April 30 |
| » Lost to Pirates (13-7), 2-1 | Forbes Field (1-1) | 8-12 | |
| » W: Jim Bunning (2-2) L: Dave Giusti (2-2) | Fourth | 6 out |
| » Defeated Pirates (13-8), 8-1 | Forbes Field (2-1) | 9-12 | |
| » W: Bob Gibson (2-2) L: Steve Blass (2-1) | Fourth | 6 out |
| Thursday, May 1 |
| » Defeated Pirates (13-9), 9-3 | Forbes Field (3-1) | 10-12 | Won 2 |
| » W: Nelson Briles (1-2) L: Bob Veale (2-3) | Third | 5½ out |
| Friday, May 2 |
| » Lost to Phillies (9-11), 7-2 | Busch Stadium II (1-9) | 10-13 | |
| » W: Jerry Johnson (2-2) L: Ray Washburn (2-3) S: Turk Farrell (1) | Fourth | 6½ out |
| Saturday, May 3 |
| » Lost to Phillies (10-11), 4-1 | Busch Stadium II (1-10) | 10-14 | Lost 2 |
| » W: Rick Wise (3-2) L: Steve Carlton (2-3) | Fourth | 7½ out |
| Sunday, May 4 |
| » Lost to Phillies (11-11), 5-0 | Busch Stadium II (1-11) | 10-15 | Lost 3 |
| » W: Grant Jackson (3-2) L: Dave Giusti (2-3) | Fifth | 7 out |
| Tuesday, May 6 |
| » Defeated Giants (15-11), 3-0 | Busch Stadium II (2-11) | 11-15 | |
| » W: Bob Gibson (3-2) L: Ray Sadecki (2-3) | Fifth | 7 out |
| Wednesday, May 7 |
| » Lost to Giants (16-11), 5-3 | Busch Stadium II (2-12) | 11-16 | |
| » W: Gaylord Perry (5-3) L: Nelson Briles (1-3) | Fifth | 7 out |
| Friday, May 9 |
| » Defeated Padres (13-18), 7-6 | Busch Stadium II (3-12) | 12-16 | |
| » W: Mike Torrez (1-0) L: Frank Reberger (0-1) S: Joe Hoerner (4) | Fifth | 6 out |
| Saturday, May 10 |
| » Lost to Padres (14-18), 5-3 | Busch Stadium II (3-13) | 12-17 | |
| » W: Johnny Podres (3-2) L: Steve Carlton (2-4) S: Frank Reberger (5) | Fifth | 6½ out |
| Sunday, May 11 |
| » Lost to Padres (15-18), 4-2 | Busch Stadium II (3-14) | 12-18 | Lost 2 |
| » W: Jack Baldschun (4-0) L: Dave Giusti (2-4) S: Tommie Sisk (3) | Fifth | 7½ out |
| Monday, May 12 |
| » Defeated Dodgers (18-12), 6-2 | Busch Stadium II (4-14) | 13-18 | |
| » W: Bob Gibson (4-2) L: Claude Osteen (4-2) | Fifth | 7½ out |
| Wednesday, May 14 |
| » Defeated Dodgers (18-13), 2-1 | Busch Stadium II (5-14) | 14-18 | Won 2 |
| » W: Nelson Briles (2-3) L: Bill Singer (5-3) S: Joe Hoerner (5) | Fourth | 8 out |
| Friday, May 16 |
| » Lost to Padres (16-21), 2-1 | San Diego/Jack Murphy Stadium (0-1) | 14-19 | |
| » W: Billy McCool (1-0) L: Ray Washburn (2-4) | Fifth | 9 out |
| Saturday, May 17 |
| » Defeated Padres (16-22), 5-1 | San Diego/Jack Murphy Stadium (1-1) | 15-19 | |
| » W: Steve Carlton (3-4) L: Clay Kirby (1-5) | Fourth | 8 out |
| Sunday, May 18 |
| » Defeated Padres (16-23), 6-5 | San Diego/Jack Murphy Stadium (2-1) | 16-19 | Won 2 |
| » W: Dave Giusti (3-4) L: Gary Ross (1-3) S: Gary Waslewski (1) | Third | 7 out |
| Tuesday, May 20 |
| » Defeated Giants (20-16), 3-0 | Candlestick Park (1-0) | 17-19 | Won 3 |
| » W: Bob Gibson (5-2) L: Mike McCormick (1-2) | Fourth | 7 out |
| Wednesday, May 21 |
| » Lost to Giants (21-16), 4-3 | Candlestick Park (1-1) | 17-20 | |
| » W: Gaylord Perry (7-3) L: Gary Waslewski (0-2) | Fourth | 7 out |
| Thursday, May 22 |
| » Defeated Giants (21-17), 8-3 | Candlestick Park (2-1) | 18-20 | |
| » W: Joe Hoerner (1-0) L: Joe Gibbon (1-2) | Fourth | 7 out |
| Friday, May 23 |
| » Defeated Dodgers (22-16), 1-0 | Dodger Stadium (1-0) | 19-20 | Won 2 |
| » W: Steve Carlton (4-4) L: Alan Foster (0-2) | Third | 7 out |
| Future Cardinal Ramon Caraballo is born in Rio San Juan, D.R. |
| Saturday, May 24 |
| » Lost to Dodgers (23-16), 5-0 | Dodger Stadium (1-1) | 19-21 | |
| » W: Don Sutton (5-4) L: Mike Torrez (1-1) | Third | 8 out |
| Sunday, May 25 |
| » Defeated Dodgers (23-17), 4-0 | Dodger Stadium (2-1) | 20-21 | |
| » W: Bob Gibson (6-2) L: Claude Osteen (6-3) | Third | 7½ out |
| Monday, May 26 |
| » Lost to Braves (27-13), 3-0 | Atlanta-Fulton County Stadium (0-1) | 20-22 | |
| » W: Phil Niekro (7-3) L: Nelson Briles (2-4) | Third | 8 out |
| Tuesday, May 27 |
| » Lost to Braves (28-13), 5-3 | Atlanta-Fulton County Stadium (0-2) | 20-23 | Lost 2 |
| » W: Pat Jarvis (5-2) L: Ray Washburn (2-5) S: Cecil Upshaw (11) | Third | 8 out |
| » Major-league debuts: Chuck Taylor (Cardinals) |
| Wednesday, May 28 |
| » Defeated Braves (28-14), 6-2 | Atlanta-Fulton County Stadium (1-2) | 21-23 | |
| » W: Steve Carlton (5-4) L: Milt Pappas (3-4) | Third | 8 out |
| » Major-league debuts: Paul Doyle (Braves) |
| Future Cardinal Mike DiFelice is born in Philadelphia, PA. |
| Friday, May 30 |
| » Lost to Reds (23-19), 4-3 | Busch Stadium II (5-15) | 21-24 | |
| » W: Clay Carroll (6-3) L: Bob Gibson (6-3) | Third | 9 out |
| Saturday, May 31 |
| » Lost to Reds (24-19), 3-1 | Busch Stadium II (5-16) | 21-25 | Lost 2 |
| » W: George Culver (3-4) L: Mike Torrez (1-2) S: Wayne Granger (4) | Fourth | 10 out |
| Sunday, June 1 |
| » Defeated Reds (24-20), 11-3 | Busch Stadium II (6-16) | 22-25 | |
| » W: Nelson Briles (3-4) L: Tony Cloninger (3-6) | Fourth | 10 out |
| » Major-league debuts: Jose Pena (Reds) |
| Monday, June 2 |
| » Lost to Braves (29-17), 6-3 | Busch Stadium II (6-17) | 22-26 | |
| » W: George Stone (6-0) L: Ray Washburn (2-6) S: Cecil Upshaw (12) | Fourth | 10½ out |
| Tuesday, June 3 |
| » Defeated Braves (29-18), 5-2 | Busch Stadium II (7-17) | 23-26 | |
| » W: Steve Carlton (6-4) L: Milt Pappas (3-5) | Fourth | 10½ out |
| Wednesday, June 4 |
| » Defeated Braves (29-19), 4-3 | Busch Stadium II (8-17) | 24-26 | Won 2 |
| » W: Bob Gibson (7-3) L: Ron Reed (5-4) | Fourth | 10½ out |
| Thursday, June 5 |
| » Lost to Astros (25-29), 11-6 | Astrodome (0-1) | 24-27 | |
| » W: Dooley Womack (2-1) L: Mike Torrez (1-3) S: Jack Billingham (2) | Fourth | 11 out |
| Friday, June 6 |
| » Defeated Astros (25-30), 6-3 | Astrodome (1-1) | 25-27 | |
| » W: Nelson Briles (4-4) L: Danny Coombs (0-1) S: Joe Hoerner (6) | Fourth | 11 out |
| Saturday, June 7 |
| » Lost to Astros (26-30), 4-2 | Astrodome (1-2) | 25-28 | |
| » W: Denny Lemaster (4-7) L: Mudcat Grant (1-7) S: Fred Gladding (11) | Fourth | 11½ out |
| Sunday, June 8 |
| » Lost to Astros (27-30), 2-1 | Astrodome (1-3) | 25-29 | Lost 2 |
| » W: Larry Dierker (8-4) L: Ron Willis (1-1) | Fourth | 12 out |
| Tuesday, June 10 |
| » Defeated Reds (27-22), 5-4 | Crosley Field (1-0) | 26-29 | |
| » W: Bob Gibson (8-3) L: Tony Cloninger (3-8) | Third | 11½ out |
| Wednesday, June 11 |
| » Defeated Reds (27-23), 10-5 | Crosley Field (2-0) | 27-29 | Won 2 |
| » W: Mudcat Grant (2-7) L: Jim Merritt (6-3) | Third | 10½ out |
| Thursday, June 12 |
| » Lost to Reds (28-23), 4-3 | Crosley Field (2-1) | 27-30 | |
| » W: Jose Pena (1-0) L: Nelson Briles (4-5) | Fourth | 11½ out |
| Friday, June 13 |
| » Lost to Astros (29-32), 4-2 | Busch Stadium II (8-18) | 27-31 | Lost 2 |
| » W: Denny Lemaster (5-7) L: Ray Washburn (2-7) S: Fred Gladding (12) | Fourth | 12½ out |
| Sunday, June 15 |
| » Defeated Astros (29-33), 5-3 | Busch Stadium II (9-18) | 28-31 | |
| » W: Bob Gibson (9-3) L: Don Wilson (5-6) | Fourth | 12 out |
| » Major-league debuts: Boots Day (Cardinals) |
| Monday, June 16 |
| » Defeated Expos (15-42), 3-0 | Busch Stadium II (10-18) | 29-31 | Won 2 |
| » W: Nelson Briles (5-5) L: Jerry Robertson (1-3) | Fourth | 11 out |
| Tuesday, June 17 |
| » Defeated Expos (15-43), 2-0 | Busch Stadium II (11-18) | 30-31 | Won 3 |
| » W: Steve Carlton (7-4) L: Dan McGinn (2-7) S: Joe Hoerner (7) | Fourth | 9½ out |
| Wednesday, June 18 |
| » Lost to Expos (16-43), 5-1 | Busch Stadium II (11-19) | 30-32 | |
| » W: Mike Wegener (3-3) L: Dave Giusti (3-5) | Fourth | 9½ out |
| Thursday, June 19 |
| » Defeated Expos (16-44), 5-3 | Busch Stadium II (12-19) | 31-32 | |
| » W: Mudcat Grant (3-7) L: Bill Stoneman (3-9) | Fourth | 9 out |
| Friday, June 20 |
| » Lost to Mets (34-27), 4-3 | Shea Stadium (3-1) | 31-33 | |
| » W: Nolan Ryan (3-0) L: Bob Gibson (9-4) S: Tug McGraw (5) | Fourth | 10 out |
| Saturday, June 21 |
| » Defeated Mets (34-28), 5-3 | Shea Stadium (4-1) | 32-33 | |
| » W: Nelson Briles (6-5) L: Jack DiLauro (0-2) | Fourth | 9 out |
| Future Cardinal Donovan Osborne is born in Roseville, CA. |
| Sunday, June 22 |
| » Lost to Mets (35-28), 5-1 | Shea Stadium (4-2) | 32-34 | |
| » W: Gary Gentry (7-5) L: Steve Carlton (7-5) S: Cal Koonce (5) | Fourth | 10 out |
| » Lost to Mets (36-28), 1-0 | Shea Stadium (4-3) | 32-35 | Lost 2 |
| » W: Jerry Koosman (5-4) L: Mike Torrez (1-4) | Fourth | 10 out |
| Tuesday, June 24 |
| » Lost to Expos (19-46), 4-1 | Parc Jarry (1-2) | 32-36 | Lost 3 |
| » W: Bill Stoneman (4-9) L: Dave Giusti (3-6) | Fourth | 11½ out |
| Wednesday, June 25 |
| » Defeated Expos (19-47), 8-1 | Parc Jarry (2-2) | 33-36 | |
| » W: Bob Gibson (10-4) L: Jerry Robertson (1-5) | Fourth | 11 out |
| » Defeated Expos (19-48), 8-3 | Parc Jarry (3-2) | 34-36 | Won 2 |
| » W: Mudcat Grant (4-7) L: Mike Wegener (3-4) | Fourth | 11 out |
| Thursday, June 26 |
| » Lost to Expos (20-48), 8-6 | Parc Jarry (3-3) | 34-37 | |
| » W: Dan McGinn (3-7) L: Nelson Briles (6-6) | Fourth | 12 out |
| Friday, June 27 |
| » Defeated Cubs (46-26), 3-1 | Wrigley Field (2-0) | 35-37 | |
| » W: Steve Carlton (8-5) L: Ken Holtzman (10-2) | Fourth | 11 out |
| Saturday, June 28 |
| » Lost to Cubs (47-26), 3-1 | Wrigley Field (2-1) | 35-38 | |
| » W: Bill Hands (8-6) L: Dave Giusti (3-7) | Fourth | 12 out |
| Sunday, June 29 |
| » Lost to Cubs (48-26), 3-1 | Wrigley Field (2-2) | 35-39 | Lost 2 |
| » W: Fergie Jenkins (10-5) L: Bob Gibson (10-5) | Fourth | 14 out |
| » Lost to Cubs (49-26), 12-1 | Wrigley Field (2-3) | 35-40 | Lost 3 |
| » W: Dick Selma (8-3) L: Mudcat Grant (4-8) | Fourth | 14 out |
| Monday, June 30 |
| » Lost to Mets (40-32), 10-2 | Busch Stadium II (12-20) | 35-41 | Lost 4 |
| » W: Jim McAndrew (2-2) L: Nelson Briles (6-7) | Fourth | 14 out |
| Tuesday, July 1 |
| » Defeated Mets (40-33), 4-1 | Busch Stadium II (13-20) | 36-41 | |
| » W: Steve Carlton (9-5) L: Nolan Ryan (3-1) | Fourth | 12½ out |
| » Defeated Mets (40-34), 8-5 | Busch Stadium II (14-20) | 37-41 | Won 2 |
| » W: Mike Torrez (2-4) L: Jack DiLauro (0-3) S: Joe Hoerner (8) | Fourth | 12½ out |
| Wednesday, July 2 |
| » Lost to Mets (41-34), 6-4 | Busch Stadium II (14-21) | 37-42 | |
| » W: Tug McGraw (5-1) L: Ron Willis (1-2) | Fifth | 13½ out |
| Future Cardinal So Taguchi is born in Hyogo Prefecture, Japan. |
| Thursday, July 3 |
| » Lost to Mets (42-34), 8-1 | Busch Stadium II (14-22) | 37-43 | Lost 2 |
| » W: Gary Gentry (8-6) L: Mudcat Grant (4-9) | Fifth | 14½ out |
| Friday, July 4 |
| » Lost to Cubs (52-28), 3-1 | Busch Stadium II (14-23) | 37-44 | Lost 3 |
| » W: Fergie Jenkins (11-5) L: Bob Gibson (10-6) | Fifth | 15½ out |
| Saturday, July 5 |
| » Defeated Cubs (52-29), 5-1 | Busch Stadium II (15-23) | 38-44 | |
| » W: Nelson Briles (7-7) L: Ken Holtzman (10-4) | Fourth | 14½ out |
| Sunday, July 6 |
| » Defeated Cubs (52-30), 4-2 | Busch Stadium II (16-23) | 39-44 | Won 2 |
| » W: Steve Carlton (10-5) L: Bill Hands (9-7) S: Joe Hoerner (9) | Third | 12½ out |
| » Defeated Cubs (52-31), 6-3 | Busch Stadium II (17-23) | 40-44 | Won 3 |
| » W: Chuck Taylor (1-0) L: Rich Nye (0-4) | Third | 12½ out |
| Tuesday, July 8 |
| » Defeated Phillies (36-44), 6-3 | Shibe Park (2-2) | 41-44 | Won 4 |
| » W: Bob Gibson (11-6) L: Jerry Johnson (4-9) | Third | 11½ out |
| Wednesday, July 9 |
| » Lost to Phillies (37-44), 7-1 | Shibe Park (2-3) | 41-45 | |
| » W: Woodie Fryman (8-5) L: Nelson Briles (7-8) | Fourth | 11 out |
| » Defeated Phillies (37-45), 5-3 | Shibe Park (3-3) | 42-45 | |
| » W: Nelson Briles (8-8) L: Lowell Palmer (1-3) S: Joe Hoerner (10) | Fourth | 11 out |
| Thursday, July 10 |
| » Defeated Phillies (37-46), 9-3 | Shibe Park (4-3) | 43-45 | Won 2 |
| » W: Mike Torrez (3-4) L: Grant Jackson (9-8) S: Mudcat Grant (1) | Fourth | 11 out |
| Friday, July 11 |
| » Defeated Pirates (42-44), 6-1 | Busch Stadium II (18-23) | 44-45 | Won 3 |
| » W: Steve Carlton (11-5) L: Luke Walker (0-1) | Third | 10 out |
| Saturday, July 12 |
| » Defeated Pirates (42-45), 6-3 | Busch Stadium II (19-23) | 45-45 | Won 4 |
| » W: Ray Washburn (3-7) L: Steve Blass (9-6) | Third | 10 out |
| Sunday, July 13 |
| » Lost to Pirates (43-45), 3-0 | Busch Stadium II (19-24) | 45-46 | |
| » W: Jim Bunning (8-6) L: Bob Gibson (11-7) S: Bob Moose (1) | Third | 11 out |
| » Defeated Pirates (43-46), 4-2 | Busch Stadium II (20-24) | 46-46 | |
| » W: Nelson Briles (9-8) L: Dock Ellis (5-10) S: Joe Hoerner (11) | Third | 11 out |
| Tuesday, July 15 |
| » Defeated Phillies (38-50), 8-2 | Busch Stadium II (21-24) | 47-46 | Won 2 |
| » W: Chuck Taylor (2-0) L: Grant Jackson (9-9) | Third | 10½ out |
| Wednesday, July 16 |
| » Defeated Phillies (38-51), 5-0 | Busch Stadium II (22-24) | 48-46 | Won 3 |
| » W: Steve Carlton (12-5) L: Bill Champion (3-4) | Third | 9½ out |
| Thursday, July 17 |
| » Defeated Phillies (38-52), 11-3 | Busch Stadium II (23-24) | 49-46 | Won 4 |
| » W: Mike Torrez (4-4) L: Rick Wise (6-8) S: Ray Washburn (1) | Third | 9 out |
| Friday, July 18 |
| » Lost to Pirates (46-48), 4-1 | Forbes Field (3-2) | 49-47 | |
| » W: Dock Ellis (6-10) L: Bob Gibson (11-8) | Third | 10 out |
| Saturday, July 19 |
| » Lost to Pirates (47-48), 3-2 | Forbes Field (3-3) | 49-48 | Lost 2 |
| » W: Bob Veale (5-11) L: Nelson Briles (9-9) S: Joe Gibbon (6) | Third | 10 out |
| Thursday, July 24 |
| » Defeated Giants (54-43), 2-1 | Busch Stadium II (24-24) | 50-48 | |
| » W: Nelson Briles (10-9) L: Juan Marichal (13-5) S: Joe Hoerner (12) | Third | 11 out |
| Friday, July 25 |
| » Defeated Giants (54-44), 2-1 | Busch Stadium II (25-24) | 51-48 | Won 2 |
| » W: Bob Gibson (12-8) L: Frank Linzy (7-6) | Third | 10 out |
| Saturday, July 26 |
| » Lost to Giants (55-44), 7-6 | Busch Stadium II (25-25) | 51-49 | |
| » W: Frank Linzy (8-6) L: Joe Hoerner (1-1) S: Ron Bryant (1) | Third | 11 out |
| Sunday, July 27 |
| » Defeated Giants (55-45), 8-2 | Busch Stadium II (26-25) | 52-49 | |
| » W: Mike Torrez (5-4) L: Bobby Bolin (5-6) | Third | 10 out |
| Monday, July 28 |
| » Defeated Padres (34-69), 2-1 | Busch Stadium II (27-25) | 53-49 | Won 2 |
| » W: Chuck Taylor (3-0) L: Dick Kelley (4-6) | Third | 10 out |
| Tuesday, July 29 |
| » Defeated Padres (34-70), 10-4 | Busch Stadium II (28-25) | 54-49 | Won 3 |
| » W: Mudcat Grant (5-9) L: Billy McCool (2-5) | Third | 9 out |
| Wednesday, July 30 |
| » Defeated Padres (34-71), 5-2 | Busch Stadium II (29-25) | 55-49 | Won 4 |
| » W: Bob Gibson (13-8) L: Joe Niekro (6-7) | Third | 8 out |
| Former Cardinal Flint Rhem dies in Columbia, SC at the age of 69. |
| Friday, August 1 |
| » Defeated Dodgers (56-47), 7-2 | Busch Stadium II (30-25) | 56-49 | Won 5 |
| » W: Steve Carlton (13-5) L: Don Drysdale (5-4) | Third | 8½ out |
| » Major-league debuts: Ray Lamb (Dodgers) |
| Saturday, August 2 |
| » Defeated Dodgers (56-48), 7-6 | Busch Stadium II (31-25) | 57-49 | Won 6 |
| » W: Mike Torrez (6-4) L: Don Sutton (12-11) S: Joe Hoerner (13) | Third | 8½ out |
| Sunday, August 3 |
| » Lost to Dodgers (57-48), 5-0 | Busch Stadium II (31-26) | 57-50 | |
| » W: Claude Osteen (14-9) L: Chuck Taylor (3-1) | Third | 9½ out |
| Future Cardinal Steve Dixon is born in Cincinnati, OH. |
| Monday, August 4 |
| » Defeated Dodgers (57-49), 2-1 | Busch Stadium II (32-26) | 58-50 | |
| » W: Nelson Briles (11-9) L: Jim Brewer (3-5) | Third | 9½ out |
| Tuesday, August 5 |
| » Defeated Padres (34-75), 2-1 | San Diego/Jack Murphy Stadium (3-1) | 59-50 | Won 2 |
| » W: Bob Gibson (14-8) L: Dick Kelley (4-7) | Third | 9½ out |
| Wednesday, August 6 |
| » Lost to Padres (35-75), 3-2 | San Diego/Jack Murphy Stadium (3-2) | 59-51 | |
| » W: Billy McCool (3-5) L: Steve Carlton (13-6) | Third | 10½ out |
| Thursday, August 7 |
| » Defeated Padres (35-76), 2-1 | San Diego/Jack Murphy Stadium (4-2) | 60-51 | |
| » W: Mike Torrez (7-4) L: Al Santorini (4-11) | Third | 10 out |
| Friday, August 8 |
| » Defeated Giants (61-50), 4-3 | Candlestick Park (3-1) | 61-51 | Won 2 |
| » W: Chuck Taylor (4-1) L: Gaylord Perry (14-8) | Third | 9 out |
| Saturday, August 9 |
| » Defeated Giants (61-51), 5-3 | Candlestick Park (4-1) | 62-51 | Won 3 |
| » W: Nelson Briles (12-9) L: Mike McCormick (8-6) | Third | 9 out |
| Sunday, August 10 |
| » Defeated Giants (61-52), 7-4 | Candlestick Park (5-1) | 63-51 | Won 4 |
| » W: Mudcat Grant (6-9) L: Don McMahon (3-6) | Third | 8 out |
| Monday, August 11 |
| » Defeated Dodgers (61-52), 4-2 | Dodger Stadium (3-1) | 64-51 | Won 5 |
| » W: Steve Carlton (14-6) L: Claude Osteen (15-10) S: Joe Hoerner (14) | Third | 7½ out |
| Tuesday, August 12 |
| » Lost to Dodgers (62-52), 5-2 | Dodger Stadium (3-2) | 64-52 | |
| » W: Bill Singer (15-7) L: Joe Hoerner (1-2) | Third | 8½ out |
| Wednesday, August 13 |
| » Defeated Dodgers (62-53), 5-0 | Dodger Stadium (4-2) | 65-52 | |
| » W: Chuck Taylor (5-1) L: Alan Foster (3-8) | Second | 8½ out |
| Friday, August 15 |
| » Lost to Braves (66-55), 8-2 | Atlanta-Fulton County Stadium (1-3) | 65-53 | |
| » W: Ron Reed (11-8) L: Nelson Briles (12-10) S: Paul Doyle (2) | Second | 8½ out |
| » Major-league debuts: Tom Hilgendorf (Cardinals) |
| Saturday, August 16 |
| » Defeated Braves (66-56), 8-1 | Atlanta-Fulton County Stadium (2-3) | 66-53 | |
| » W: Bob Gibson (15-8) L: Jim Britton (6-4) | Third | 8½ out |
| Sunday, August 17 |
| » Defeated Braves (66-57), 5-3 | Atlanta-Fulton County Stadium (3-3) | 67-53 | Won 2 |
| » W: Steve Carlton (15-6) L: Milt Pappas (6-10) S: Mudcat Grant (2) | Third | 8 out |
| Tuesday, August 19 |
| » Lost to Reds (65-51), 8-4 | Busch Stadium II (32-27) | 67-54 | |
| » W: Jim Maloney (6-3) L: Ray Washburn (3-8) S: Clay Carroll (6) | Third | 9 out |
| Wednesday, August 20 |
| » Defeated Reds (65-52), 2-1 | Busch Stadium II (33-27) | 68-54 | |
| » W: Chuck Taylor (6-1) L: Gary Nolan (3-5) | Third | 8 out |
| Thursday, August 21 |
| » Lost to Reds (66-52), 5-3 | Busch Stadium II (33-28) | 68-55 | |
| » W: Jim Merritt (14-5) L: Nelson Briles (12-11) S: Al Jackson (3) | Third | 8 out |
| Friday, August 22 |
| » Defeated Braves (68-59), 4-2 | Busch Stadium II (34-28) | 69-55 | |
| » W: Bob Gibson (16-8) L: Gary Neibauer (1-2) | Third | 7 out |
| Saturday, August 23 |
| » Lost to Braves (69-59), 3-1 | Busch Stadium II (34-29) | 69-56 | |
| » W: Phil Niekro (17-11) L: Steve Carlton (15-7) | Third | 8 out |
| Sunday, August 24 |
| » Lost to Braves (70-59), 4-1 | Busch Stadium II (34-30) | 69-57 | Lost 2 |
| » W: George Stone (10-8) L: Mudcat Grant (6-10) | Third | 8½ out |
| Tuesday, August 26 |
| » Defeated Astros (66-60), 1-0 | Busch Stadium II (35-30) | 70-57 | |
| » W: Nelson Briles (13-11) L: Larry Dierker (16-10) | Third | 7½ out |
| » Lost to Astros (67-60), 4-2 | Busch Stadium II (35-31) | 70-58 | |
| » W: Denny Lemaster (10-13) L: Joe Hoerner (1-3) | Third | 7½ out |
| Future Cardinal Ricky Bottalico is born in New Britain, CT. |
| Wednesday, August 27 |
| » Lost to Astros (68-60), 5-1 | Busch Stadium II (35-32) | 70-59 | Lost 2 |
| » W: Tom Griffin (9-6) L: Bob Gibson (16-9) S: Fred Gladding (27) | Third | 7½ out |
| Thursday, August 28 |
| » Defeated Astros (68-61), 2-1 | Busch Stadium II (36-32) | 71-59 | |
| » W: Mudcat Grant (7-10) L: Don Wilson (16-9) | Third | 7½ out |
| Friday, August 29 |
| » Lost to Reds (70-57), 8-1 | Crosley Field (2-2) | 71-60 | |
| » W: Jim Maloney (7-4) L: Chuck Taylor (6-2) | Third | 8½ out |
| Saturday, August 30 |
| » Lost to Reds (71-57), 4-3 | Crosley Field (2-3) | 71-61 | Lost 2 |
| » W: Gary Nolan (5-5) L: Nelson Briles (13-12) S: Wayne Granger (18) | Third | 9½ out |
| Sunday, August 31 |
| » Lost to Reds (72-57), 7-5 | Crosley Field (2-4) | 71-62 | Lost 3 |
| » W: Jim Merritt (16-5) L: Bob Gibson (16-10) S: Wayne Granger (19) | Fourth | 10½ out |
| Monday, September 1 |
| » Defeated Astros (69-64), 6-2 | Astrodome (2-3) | 72-62 | |
| » W: Steve Carlton (16-7) L: Don Wilson (16-10) S: Mudcat Grant (3) | Fourth | 10 out |
| Tuesday, September 2 |
| » Lost to Astros (70-64), 7-6 | Astrodome (2-4) | 72-63 | |
| » W: Fred Gladding (3-6) L: Mudcat Grant (7-11) | Fourth | 11½ out |
| Friday, September 5 |
| » Defeated Expos (41-96), 1-0 | Busch Stadium II (37-32) | 73-63 | |
| » W: Nelson Briles (14-12) L: Howie Reed (6-5) | Fourth | 10 out |
| Saturday, September 6 |
| » Lost to Expos (42-96), 3-2 | Busch Stadium II (37-33) | 73-64 | |
| » W: Jerry Robertson (5-12) L: Bob Gibson (16-11) S: Dan McGinn (6) | Fourth | 10 out |
| Sunday, September 7 |
| » Lost to Expos (43-96), 3-0 | Busch Stadium II (37-34) | 73-65 | Lost 2 |
| » W: Bill Stoneman (9-16) L: Steve Carlton (16-8) | Fourth | 10 out |
| Future Cardinal Darren Bragg is born in Waterbury, CT. |
| Monday, September 8 |
| » Defeated Phillies (55-83), 4-3 | Shibe Park (5-3) | 74-65 | |
| » W: Chuck Taylor (7-2) L: Woodie Fryman (11-12) S: Mudcat Grant (4) | Fourth | 9 out |
| Tuesday, September 9 |
| » Defeated Phillies (55-84), 6-2 | Shibe Park (6-3) | 75-65 | Won 2 |
| » W: Nelson Briles (15-12) L: Grant Jackson (12-15) S: Mudcat Grant (5) | Fourth | 8 out |
| Wednesday, September 10 |
| » Defeated Pirates (75-63), 11-2 | Forbes Field (4-3) | 76-65 | Won 3 |
| » W: Bob Gibson (17-11) L: Steve Blass (14-9) | Third | 7½ out |
| » Defeated Pirates (75-64), 2-1 | Forbes Field (5-3) | 77-65 | Won 4 |
| » W: Mike Torrez (8-4) L: Bo Belinsky (0-2) S: Mudcat Grant (6) | Third | 7½ out |
| Former Cardinal Jap Barbeau dies in Milwaukee, WI at the age of 88. |
| Thursday, September 11 |
| » Lost to Pirates (76-64), 3-2 | Forbes Field (5-4) | 77-66 | |
| » W: Bob Veale (12-11) L: Steve Carlton (16-9) | Fourth | 8½ out |
| Future Cardinal Eduardo Perez is born in Cincinnati, OH. |
| Friday, September 12 |
| » Lost to Cubs (85-60), 5-1 | Busch Stadium II (37-35) | 77-67 | Lost 2 |
| » W: Bill Hands (17-13) L: Chuck Taylor (7-3) | Third | 10 out |
| Saturday, September 13 |
| » Defeated Cubs (85-61), 7-4 | Busch Stadium II (38-35) | 78-67 | |
| » W: Mudcat Grant (8-11) L: Fergie Jenkins (19-14) S: Joe Hoerner (15) | Third | 10 out |
| Sunday, September 14 |
| » Defeated Cubs (85-62), 2-1 | Busch Stadium II (39-35) | 79 |