| Monday, January 6 |
| Future Astro Alvin Morman is born in Rockingham, NC. |
| Monday, January 13 |
| Future Astro Orlando Miller is born in Changuinola, Panama. |
| Monday, January 27 |
| Future Astro Phil Plantier is born in Manchester, NH. |
| Saturday, February 15 |
| Future Astro Brian Williams is born in Lancaster, SC. |
| Sunday, February 23 |
| Future Astro Frank Charles is born in Fontana, CA. |
| Monday, March 24 |
| Future Astro Jose Cabrera is born in Santiago, D.R. |
| Sunday, March 30 |
| Future Astro Chris Gardner is born in Long Beach, CA. |
| Monday, April 7 |
| » Major-league debuts: Bob Didier (Braves) |
| Tuesday, April 8 |
| » Lost to Padres (1-0), 2-1 | San Diego/Jack Murphy Stadium (0-1) | 0-1 | |
| » W: Dick Selma (1-0) L: Don Wilson (0-1) | Third | 1½ out |
| Wednesday, April 9 |
| » Lost to Padres (2-0), 2-0 | San Diego/Jack Murphy Stadium (0-2) | 0-2 | Lost 2 |
| » W: Johnny Podres (1-0) L: Larry Dierker (0-1) S: Tommie Sisk (1) | Fourth | 2½ out |
| Thursday, April 10 |
| » Lost to Padres (3-0), 2-0 | San Diego/Jack Murphy Stadium (0-3) | 0-3 | Lost 3 |
| » W: Dick Kelley (1-0) L: Tom Griffin (0-1) S: Billy McCool (1) | Third | 3 out |
| » Major-league debuts: Tom Griffin (Astros) |
| Friday, April 11 |
| » Lost to Dodgers (2-1), 9-3 | Astrodome (0-1) | 0-4 | Lost 4 |
| » W: Claude Osteen (1-0) L: Denny Lemaster (0-1) | Sixth | 4 out |
| Saturday, April 12 |
| » Lost to Dodgers (3-1), 5-1 | Astrodome (0-2) | 0-5 | Lost 5 |
| » W: Bill Singer (1-0) L: Wade Blasingame (0-1) S: Jim Brewer (1) | Sixth | 4 out |
| Sunday, April 13 |
| » Defeated Dodgers (3-2), 5-2 | Astrodome (1-2) | 1-5 | |
| » W: Don Wilson (1-1) L: Don Drysdale (1-1) | Fifth | 4½ out |
| Monday, April 14 |
| » Defeated Dodgers (3-3), 11-5 | Astrodome (2-2) | 2-5 | Won 2 |
| » W: Larry Dierker (1-1) L: Don Sutton (0-2) S: Fred Gladding (1) | Fourth | 4 out |
| Future Astro Brad Ausmus is born in New Haven, CT. |
| Tuesday, April 15 |
| » Defeated Braves (6-2), 4-2 | Astrodome (3-2) | 3-5 | Won 3 |
| » W: Tom Griffin (1-1) L: Milt Pappas (1-1) S: Jack Billingham (1) | Fourth | 3 out |
| Wednesday, April 16 |
| » Lost to Braves (7-2), 6-4 | Astrodome (3-3) | 3-6 | |
| » W: George Stone (3-0) L: Denny Lemaster (0-2) S: Cecil Upshaw (3) | Fifth | 4 out |
| » Major-league debuts: Cesar Geronimo (Astros) |
| Thursday, April 17 |
| » Lost to Braves (8-2), 9-3 | Astrodome (3-4) | 3-7 | Lost 2 |
| » W: Pat Jarvis (1-1) L: Wade Blasingame (0-2) | Sixth | 5 out |
| Friday, April 18 |
| » Lost to Dodgers (6-3), 5-4 | Dodger Stadium (0-1) | 3-8 | Lost 3 |
| » W: Al McBean (1-1) L: Jack Billingham (0-1) | Sixth | 5½ out |
| Saturday, April 19 |
| » Lost to Dodgers (7-3), 5-4 | Dodger Stadium (0-2) | 3-9 | Lost 4 |
| » W: Pete Mikkelsen (1-0) L: Larry Dierker (1-2) | Sixth | 6½ out |
| Sunday, April 20 |
| » Lost to Dodgers (8-3), 2-1 | Dodger Stadium (0-3) | 3-10 | Lost 5 |
| » W: Claude Osteen (3-0) L: Denny Lemaster (0-3) | Sixth | 6½ out |
| Monday, April 21 |
| » Lost to Reds (5-5), 11-5 | Astrodome (3-5) | 3-11 | Lost 6 |
| » W: Jim Merritt (1-0) L: Wade Blasingame (0-3) S: Wayne Granger (2) | Sixth | 7½ out |
| Tuesday, April 22 |
| » Lost to Reds (6-5), 14-0 | Astrodome (3-6) | 3-12 | Lost 7 |
| » W: Mel Queen (1-0) L: Don Wilson (1-2) S: Clay Carroll (1) | Sixth | 7½ out |
| Wednesday, April 23 |
| » Defeated Padres (5-10), 4-0 | Astrodome (4-6) | 4-12 | |
| » W: Larry Dierker (2-2) L: Clay Kirby (0-3) | Fifth | 7 out |
| Thursday, April 24 |
| » Lost to Padres (6-10), 4-1 | Astrodome (4-7) | 4-13 | |
| » W: Jack Baldschun (1-0) L: Jack Billingham (0-2) | Fifth | 7 out |
| Friday, April 25 |
| » Lost to Giants (9-6), 12-8 | Candlestick Park (0-1) | 4-14 | Lost 2 |
| » W: Joe Gibbon (1-0) L: Dan Schneider (0-1) | Sixth | 8 out |
| Saturday, April 26 |
| » Lost to Giants (10-6), 2-1 | Candlestick Park (0-2) | 4-15 | Lost 3 |
| » W: Juan Marichal (3-1) L: Wade Blasingame (0-4) | Fifth | 8 out |
| Sunday, April 27 |
| » Lost to Giants (11-6), 8-5 | Candlestick Park (0-3) | 4-16 | Lost 4 |
| » W: Ron Herbel (1-0) L: Don Wilson (1-3) S: Frank Linzy (2) | Fifth | 9½ out |
| » Lost to Giants (12-6), 4-3 | Candlestick Park (0-4) | 4-17 | Lost 5 |
| » W: Mike McCormick (1-0) L: Tom Griffin (1-2) S: Frank Linzy (3) | Fifth | 9½ out |
| Monday, April 28 |
| » Lost to Braves (12-7), 12-1 | Atlanta-Fulton County Stadium (0-1) | 4-18 | Lost 6 |
| » W: George Stone (4-0) L: Larry Dierker (2-3) S: Ken Johnson (1) | Fifth | 10½ out |
| Tuesday, April 29 |
| » Lost to Braves (13-7), 2-1 | Atlanta-Fulton County Stadium (0-2) | 4-19 | Lost 7 |
| » W: Milt Pappas (2-2) L: Denny Lemaster (0-4) S: Cecil Upshaw (6) | Fifth | 11½ out |
| Wednesday, April 30 |
| » Lost to Reds (9-11), 10-0 | Crosley Field (0-1) | 4-20 | Lost 8 |
| » W: Jim Maloney (3-0) L: Wade Blasingame (0-5) | Fifth | 12½ out |
| Thursday, May 1 |
| » Defeated Reds (9-12), 4-0 | Crosley Field (1-1) | 5-20 | |
| » W: Don Wilson (2-3) L: Jim Merritt (1-2) | Fifth | 11½ out |
| » Major-league debuts: John Noriega (Reds) |
| Friday, May 2 |
| » Defeated Giants (15-8), 3-1 | Astrodome (5-7) | 6-20 | Won 2 |
| » W: Jack Billingham (1-2) L: Gaylord Perry (4-3) | Fourth | 10½ out |
| Saturday, May 3 |
| » Defeated Giants (15-9), 4-3 | Astrodome (6-7) | 7-20 | Won 3 |
| » W: Larry Dierker (3-3) L: Bobby Bolin (1-2) S: Fred Gladding (2) | Fifth | 10½ out |
| Sunday, May 4 |
| » Defeated Giants (15-10), 3-1 | Astrodome (7-7) | 8-20 | Won 4 |
| » W: Dooley Womack (1-0) L: Juan Marichal (4-2) S: Fred Gladding (3) | Fifth | 10½ out |
| Tuesday, May 6 |
| » Lost to Phillies (12-11), 5-4 | Shibe Park (0-1) | 8-21 | |
| » W: Turk Farrell (1-0) L: Dooley Womack (1-1) | Fifth | 10½ out |
| Wednesday, May 7 |
| » Defeated Phillies (12-12), 6-1 | Shibe Park (1-1) | 9-21 | |
| » W: Larry Dierker (4-3) L: Jerry Johnson (2-3) | Fifth | 10½ out |
| Thursday, May 8 |
| » Defeated Phillies (12-13), 9-7 | Shibe Park (2-1) | 10-21 | Won 2 |
| » W: Jack Billingham (2-2) L: Gary Wagner (0-2) S: Fred Gladding (4) | Fifth | 10 out |
| Saturday, May 10 |
| » Lost to Mets (13-15), 3-1 | Shea Stadium (0-1) | 10-22 | |
| » W: Tom Seaver (4-2) L: Denny Lemaster (0-5) | Sixth | 11 out |
| Future Astro Pete Schourek is born in Austin, TX. |
| Sunday, May 11 |
| » Defeated Mets (13-16), 4-1 | Shea Stadium (1-1) | 11-22 | |
| » W: Larry Dierker (5-3) L: Don Cardwell (1-5) | Sixth | 11½ out |
| » Lost to Mets (14-16), 11-7 | Shea Stadium (1-2) | 11-23 | |
| » W: Cal Koonce (1-3) L: Don Wilson (2-4) | Sixth | 11½ out |
| Tuesday, May 13 |
| » Defeated Expos (11-18), 10-3 | Parc Jarry (1-0) | 12-23 | |
| » W: Jack Billingham (3-2) L: Dan McGinn (2-1) | Sixth | 11½ out |
| Wednesday, May 14 |
| » Defeated Expos (11-19), 3-1 | Parc Jarry (2-0) | 13-23 | Won 2 |
| » W: Denny Lemaster (1-5) L: Mudcat Grant (1-4) | Sixth | 10½ out |
| Friday, May 16 |
| » Lost to Cubs (24-11), 11-0 | Astrodome (7-8) | 13-24 | |
| » W: Ken Holtzman (6-1) L: Larry Dierker (5-4) | Sixth | 12 out |
| Saturday, May 17 |
| » Defeated Cubs (24-12), 5-4 | Astrodome (8-8) | 14-24 | |
| » W: Don Wilson (3-4) L: Don Nottebart (1-1) S: Fred Gladding (5) | Sixth | 11½ out |
| Sunday, May 18 |
| » Defeated Cubs (24-13), 6-5 | Astrodome (9-8) | 15-24 | Won 2 |
| » W: Jim Ray (1-0) L: Phil Regan (5-1) S: Fred Gladding (6) | Sixth | 11½ out |
| Tuesday, May 20 |
| » Defeated Expos (11-22), 5-0 | Astrodome (10-8) | 16-24 | Won 3 |
| » W: Larry Dierker (6-4) L: Mudcat Grant (1-5) | Fifth | 11 out |
| Wednesday, May 21 |
| » Defeated Expos (11-23), 3-2 | Astrodome (11-8) | 17-24 | Won 4 |
| » W: Denny Lemaster (2-5) L: Bill Stoneman (3-4) S: Fred Gladding (7) | Fifth | 10 out |
| Thursday, May 22 |
| » Defeated Expos (11-24), 7-4 | Astrodome (12-8) | 18-24 | Won 5 |
| » W: Don Wilson (4-4) L: Larry Jaster (1-3) S: Fred Gladding (8) | Fifth | 10 out |
| Friday, May 23 |
| » Defeated Mets (18-20), 7-0 | Astrodome (13-8) | 19-24 | Won 6 |
| » W: Tom Griffin (2-2) L: Gary Gentry (3-4) | Fifth | 9 out |
| Saturday, May 24 |
| » Defeated Mets (18-21), 5-1 | Astrodome (14-8) | 20-24 | Won 7 |
| » W: Larry Dierker (7-4) L: Jerry Koosman (1-3) | Fifth | 8 out |
| Sunday, May 25 |
| » Defeated Mets (18-22), 6-3 | Astrodome (15-8) | 21-24 | Won 8 |
| » W: Denny Lemaster (3-5) L: Tom Seaver (6-3) S: Fred Gladding (9) | Fifth | 8 out |
| Tuesday, May 27 |
| » Defeated Phillies (17-22), 6-2 | Astrodome (16-8) | 22-24 | Won 9 |
| » W: Don Wilson (5-4) L: Bill Wilson (0-2) | Fifth | 8½ out |
| Wednesday, May 28 |
| » Defeated Phillies (17-23), 7-6 | Astrodome (17-8) | 23-24 | Won 10 |
| » W: Jim Ray (2-0) L: Barry Lersch (0-3) | Fifth | 7½ out |
| Friday, May 30 |
| » Lost to Pirates (23-22), 9-3 | Forbes Field (0-1) | 23-25 | |
| » W: Jim Bunning (5-4) L: Denny Lemaster (3-6) | Fifth | 7 out |
| » Defeated Pirates (23-23), 9-6 | Forbes Field (1-1) | 24-25 | |
| » W: Jack Billingham (4-2) L: Chuck Hartenstein (2-1) S: Fred Gladding (10) | Fifth | 7 out |
| » Major-league debuts: Lou Marone (Pirates) |
| Saturday, May 31 |
| » Lost to Pirates (24-23), 3-1 | Forbes Field (1-2) | 24-26 | |
| » W: Dock Ellis (3-5) L: Jim Ray (2-1) S: Ron Kline (3) | Fifth | 7 out |
| Sunday, June 1 |
| » Lost to Pirates (25-23), 14-7 | Forbes Field (1-3) | 24-27 | Lost 2 |
| » W: Steve Blass (4-2) L: Don Wilson (5-5) | Fifth | 7 out |
| Tuesday, June 3 |
| » Lost to Cubs (34-16), 4-2 | Wrigley Field (0-1) | 24-28 | Lost 3 |
| » W: Bill Hands (5-5) L: Denny Lemaster (3-7) | Fifth | 7½ out |
| Wednesday, June 4 |
| » Lost to Cubs (35-16), 5-4 | Wrigley Field (0-2) | 24-29 | Lost 4 |
| » W: Fergie Jenkins (8-2) L: Tom Griffin (2-3) | Fifth | 7½ out |
| Thursday, June 5 |
| » Defeated Cardinals (24-27), 11-6 | Astrodome (18-8) | 25-29 | |
| » W: Dooley Womack (2-1) L: Mike Torrez (1-3) S: Jack Billingham (2) | Fifth | 7 out |
| Friday, June 6 |
| » Lost to Cardinals (25-27), 6-3 | Astrodome (18-9) | 25-30 | |
| » W: Nelson Briles (4-4) L: Danny Coombs (0-1) S: Joe Hoerner (6) | Fifth | 8 out |
| Saturday, June 7 |
| » Defeated Cardinals (25-28), 4-2 | Astrodome (19-9) | 26-30 | |
| » W: Denny Lemaster (4-7) L: Mudcat Grant (1-7) S: Fred Gladding (11) | Fifth | 7 out |
| Sunday, June 8 |
| » Defeated Cardinals (25-29), 2-1 | Astrodome (20-9) | 27-30 | Won 2 |
| » W: Larry Dierker (8-4) L: Ron Willis (1-1) | Fifth | 7½ out |
| Tuesday, June 10 |
| » Defeated Pirates (26-29), 7-4 | Astrodome (21-9) | 28-30 | Won 3 |
| » W: Tom Griffin (3-3) L: Dock Ellis (3-7) | Fifth | 6½ out |
| Wednesday, June 11 |
| » Lost to Pirates (27-29), 13-8 | Astrodome (21-10) | 28-31 | |
| » W: Steve Blass (6-2) L: Skip Guinn (0-1) S: Chuck Hartenstein (7) | Fifth | 7½ out |
| Thursday, June 12 |
| » Lost to Pirates (28-29), 4-3 | Astrodome (21-11) | 28-32 | Lost 2 |
| » W: Jim Bunning (6-4) L: Fred Gladding (0-1) | Fifth | 7½ out |
| Friday, June 13 |
| » Defeated Cardinals (27-31), 4-2 | Busch Stadium II (1-0) | 29-32 | |
| » W: Denny Lemaster (5-7) L: Ray Washburn (2-7) S: Fred Gladding (12) | Fifth | 6½ out |
| Sunday, June 15 |
| » Lost to Cardinals (28-31), 5-3 | Busch Stadium II (1-1) | 29-33 | |
| » W: Bob Gibson (9-3) L: Don Wilson (5-6) | Fourth | 7 out |
| » Major-league debuts: Boots Day (Cardinals) |
| Monday, June 16 |
| » Lost to Braves (35-24), 6-2 | Atlanta-Fulton County Stadium (0-3) | 29-34 | Lost 2 |
| » W: Phil Niekro (11-4) L: Larry Dierker (8-5) | Fourth | 9 out |
| » Lost to Braves (36-24), 8-4 | Atlanta-Fulton County Stadium (0-4) | 29-35 | Lost 3 |
| » W: Pat Jarvis (6-4) L: Jim Ray (2-2) | Fourth | 9 out |
| Tuesday, June 17 |
| » Lost to Braves (37-24), 6-5 | Atlanta-Fulton County Stadium (0-5) | 29-36 | Lost 4 |
| » W: Cecil Upshaw (2-2) L: Jack Billingham (4-3) | Fifth | 10 out |
| Wednesday, June 18 |
| » Defeated Braves (37-25), 3-1 | Atlanta-Fulton County Stadium (1-5) | 30-36 | |
| » W: Denny Lemaster (6-7) L: George Stone (6-1) | Fifth | 9 out |
| Thursday, June 19 |
| » Defeated Padres (26-42), 4-2 | Astrodome (22-11) | 31-36 | Won 2 |
| » W: Don Wilson (6-6) L: Al Santorini (3-5) | Fifth | 8½ out |
| Friday, June 20 |
| » Defeated Padres (26-43), 6-1 | Astrodome (23-11) | 32-36 | Won 3 |
| » W: Larry Dierker (9-5) L: Clay Kirby (2-8) | Fifth | 8 out |
| » Defeated Padres (26-44), 3-1 | Astrodome (24-11) | 33-36 | Won 4 |
| » W: Jim Ray (3-2) L: Tommie Sisk (0-5) S: Fred Gladding (13) | Fifth | 8 out |
| Saturday, June 21 |
| » Defeated Padres (26-45), 4-0 | Astrodome (25-11) | 34-36 | Won 5 |
| » W: Tom Griffin (4-3) L: Dick Kelley (3-5) | Fourth | 7 out |
| Sunday, June 22 |
| » Defeated Padres (26-46), 2-0 | Astrodome (26-11) | 35-36 | Won 6 |
| » W: Denny Lemaster (7-7) L: Joe Niekro (2-5) | Fifth | 7 out |
| Monday, June 23 |
| » Defeated Giants (36-31), 9-3 | Astrodome (27-11) | 36-36 | Won 7 |
| » W: Don Wilson (7-6) L: Ray Sadecki (3-7) | Fifth | 7 out |
| Tuesday, June 24 |
| » Defeated Giants (36-32), 4-1 | Astrodome (28-11) | 37-36 | Won 8 |
| » W: Larry Dierker (10-5) L: Gaylord Perry (9-6) | Fifth | 6 out |
| Wednesday, June 25 |
| » Defeated Giants (36-33), 3-2 | Astrodome (29-11) | 38-36 | Won 9 |
| » W: Tom Griffin (5-3) L: Mike McCormick (4-4) S: Fred Gladding (14) | Fifth | 5½ out |
| Friday, June 27 |
| » Defeated Braves (41-30), 5-4 | Astrodome (30-11) | 39-36 | Won 10 |
| » W: Fred Gladding (1-1) L: Cecil Upshaw (3-3) | Fourth | 4½ out |
| Saturday, June 28 |
| » Lost to Braves (42-30), 5-1 | Astrodome (30-12) | 39-37 | |
| » W: George Stone (7-2) L: Don Wilson (7-7) | Fifth | 5½ out |
| Sunday, June 29 |
| » Lost to Braves (43-30), 4-3 | Astrodome (30-13) | 39-38 | Lost 2 |
| » W: Paul Doyle (1-0) L: Fred Gladding (1-2) S: Cecil Upshaw (15) | Fifth | 6½ out |
| Monday, June 30 |
| » Lost to Dodgers (44-29), 7-1 | Dodger Stadium (0-4) | 39-39 | Lost 3 |
| » W: Claude Osteen (10-6) L: Tom Griffin (5-4) | Fifth | 7½ out |
| Tuesday, July 1 |
| » Lost to Dodgers (45-29), 4-1 | Dodger Stadium (0-5) | 39-40 | Lost 4 |
| » W: Bill Singer (10-6) L: Denny Lemaster (7-8) | Fifth | 8½ out |
| Wednesday, July 2 |
| » Defeated Dodgers (45-30), 8-2 | Dodger Stadium (1-5) | 40-40 | |
| » W: Don Wilson (8-7) L: Don Sutton (11-7) S: Fred Gladding (15) | Fifth | 8 out |
| Friday, July 4 |
| » Defeated Padres (27-55), 4-0 | San Diego/Jack Murphy Stadium (1-3) | 41-40 | Won 2 |
| » W: Larry Dierker (11-5) L: Al Santorini (3-7) | Fifth | 7 out |
| Saturday, July 5 |
| » Lost to Padres (28-55), 9-8 | San Diego/Jack Murphy Stadium (1-4) | 41-41 | |
| » W: Frank Reberger (1-1) L: Skip Guinn (0-2) | Fifth | 8 out |
| Sunday, July 6 |
| » Defeated Padres (28-56), 3-2 | San Diego/Jack Murphy Stadium (2-4) | 42-41 | |
| » W: Jim Ray (4-2) L: Dave Roberts (0-1) S: Denny Lemaster (1) | Fifth | 7 out |
| » Lost to Padres (29-56), 1-0 | San Diego/Jack Murphy Stadium (2-5) | 42-42 | |
| » W: Dick Kelley (4-5) L: Jack Billingham (4-4) | Fifth | 7 out |
| » Major-league debuts: Dave Roberts (Padres) |
| Monday, July 7 |
| » Defeated Giants (45-39), 8-2 | Candlestick Park (1-4) | 43-42 | |
| » W: Don Wilson (9-7) L: Ray Sadecki (3-8) | Fifth | 7 out |
| Tuesday, July 8 |
| » Lost to Giants (46-39), 7-4 | Candlestick Park (1-5) | 43-43 | |
| » W: Frank Linzy (6-4) L: Larry Dierker (11-6) | Fifth | 7 out |
| Wednesday, July 9 |
| » Lost to Giants (47-39), 10-3 | Candlestick Park (1-6) | 43-44 | Lost 2 |
| » W: Ron Bryant (1-0) L: Denny Lemaster (7-9) S: Frank Linzy (8) | Fifth | 8 out |
| Thursday, July 10 |
| » Lost to Reds (45-35), 5-4 | Astrodome (30-14) | 43-45 | Lost 3 |
| » W: Wayne Granger (3-2) L: Fred Gladding (1-3) | Fifth | 8 out |
| Friday, July 11 |
| » Defeated Reds (45-36), 13-2 | Astrodome (31-14) | 44-45 | |
| » W: Don Wilson (10-7) L: Jim Maloney (3-2) | Fifth | 7½ out |
| » Major-league debuts: Clyde Mashore (Reds) |
| Saturday, July 12 |
| » Defeated Reds (45-37), 10-4 | Astrodome (32-14) | 45-45 | Won 2 |
| » W: Larry Dierker (12-6) L: Tony Cloninger (6-12) | Fifth | 7 out |
| Sunday, July 13 |
| » Defeated Reds (45-38), 9-6 | Astrodome (33-14) | 46-45 | Won 3 |
| » W: Jim Ray (5-2) L: Wayne Granger (3-3) S: Fred Gladding (16) | Fifth | 6 out |
| Monday, July 14 |
| » Lost to Dodgers (51-37), 4-1 | Astrodome (33-15) | 46-46 | |
| » W: Don Sutton (12-9) L: Denny Lemaster (7-10) S: Jim Brewer (14) | Fifth | 7 out |
| Tuesday, July 15 |
| » Defeated Dodgers (51-38), 10-7 | Astrodome (34-15) | 47-46 | |
| » W: Skip Guinn (1-2) L: Pete Mikkelsen (3-3) S: Fred Gladding (17) | Fifth | 6 out |
| Wednesday, July 16 |
| » Lost to Dodgers (52-38), 3-2 | Astrodome (34-16) | 47-47 | |
| » W: Claude Osteen (12-7) L: Larry Dierker (12-7) | Fifth | 7 out |
| Friday, July 18 |
| » Defeated Reds (47-41), 7-4 | Crosley Field (2-1) | 48-47 | |
| » W: Jim Ray (6-2) L: Pedro Ramos (2-3) S: Fred Gladding (18) | Fifth | 6½ out |
| Saturday, July 19 |
| » Lost to Reds (48-41), 10-9 | Crosley Field (2-2) | 48-48 | |
| » W: Pedro Ramos (3-3) L: Jack Billingham (4-5) | Fifth | 6½ out |
| Thursday, July 24 |
| » Defeated Phillies (39-56), 7-3 | Astrodome (35-16) | 49-48 | |
| » W: Don Wilson (11-7) L: Rick Wise (7-9) | Fifth | 7 out |
| Friday, July 25 |
| » Lost to Phillies (40-56), 7-3 | Astrodome (35-17) | 49-49 | |
| » W: Grant Jackson (10-10) L: Larry Dierker (12-8) | Fifth | 7 out |
| Saturday, July 26 |
| » Defeated Phillies (40-57), 4-2 | Astrodome (36-17) | 50-49 | |
| » W: Tom Griffin (6-4) L: Lowell Palmer (1-5) S: Fred Gladding (19) | Fifth | 6 out |
| Sunday, July 27 |
| » Defeated Phillies (40-58), 3-2 | Astrodome (37-17) | 51-49 | Won 2 |
| » W: Fred Gladding (2-3) L: Bill Wilson (2-4) | Fifth | 6 out |
| Tuesday, July 29 |
| Future Astro Mike Williams is born in Radford, VA. |
| Wednesday, July 30 |
| » Defeated Mets (55-42), 16-3 | Shea Stadium (2-2) | 52-49 | Won 3 |
| » W: Don Wilson (12-7) L: Jerry Koosman (8-6) S: Fred Gladding (20) | Fifth | 5 out |
| » Defeated Mets (55-43), 11-5 | Shea Stadium (3-2) | 53-49 | Won 4 |
| » W: Larry Dierker (13-8) L: Gary Gentry (9-9) S: Fred Gladding (21) | Fifth | 5 out |
| Thursday, July 31 |
| » Defeated Mets (55-44), 2-0 | Shea Stadium (4-2) | 54-49 | Won 5 |
| » W: Tom Griffin (7-4) L: Tom Seaver (15-6) S: Fred Gladding (22) | Fifth | 4½ out |
| Friday, August 1 |
| » Defeated Expos (33-71), 5-3 | Parc Jarry (3-0) | 55-49 | Won 6 |
| » W: Denny Lemaster (8-10) L: Steve Renko (1-3) | Fifth | 3½ out |
| Saturday, August 2 |
| » Defeated Expos (33-72), 5-3 | Parc Jarry (4-0) | 56-49 | Won 7 |
| » W: Jim Ray (7-2) L: Mike Wegener (4-8) S: Fred Gladding (23) | Fifth | 2½ out |
| Sunday, August 3 |
| » Defeated Expos (33-73), 7-3 | Parc Jarry (5-0) | 57-49 | Won 8 |
| » W: Don Wilson (13-7) L: Bill Stoneman (6-14) | Fifth | 4 out |
| » Lost to Expos (34-73), 1-0 | Parc Jarry (5-1) | 57-50 | |
| » W: Howie Reed (6-2) L: Larry Dierker (13-9) | Fifth | 4 out |
| Monday, August 4 |
| » Lost to Cubs (68-41), 9-3 | Astrodome (37-18) | 57-51 | Lost 2 |
| » W: Fergie Jenkins (15-9) L: Tom Griffin (7-5) | Fifth | 4 out |
| Tuesday, August 5 |
| » Lost to Cubs (69-41), 5-2 | Astrodome (37-19) | 57-52 | Lost 3 |
| » W: Bill Hands (13-8) L: Denny Lemaster (8-11) S: Phil Regan (13) | Fifth | 4 out |
| Wednesday, August 6 |
| » Lost to Cubs (70-41), 5-4 | Astrodome (37-20) | 57-53 | Lost 4 |
| » W: Rich Nye (2-5) L: Jack Billingham (4-6) S: Dick Selma (1) | Fifth | 4½ out |
| Friday, August 8 |
| » Defeated Expos (35-77), 5-2 | Astrodome (38-20) | 58-53 | |
| » W: Don Wilson (14-7) L: Howie Reed (6-3) S: Wade Blasingame (1) | Fifth | 4½ out |
| Future Astro Ray Montgomery is born in Bronxville, NY. |
| Saturday, August 9 |
| » Defeated Expos (35-78), 5-3 | Astrodome (39-20) | 59-53 | Won 2 |
| » W: Jack Billingham (5-6) L: Dick Radatz (2-5) | Fifth | 4½ out |
| Sunday, August 10 |
| » Defeated Expos (35-79), 3-1 | Astrodome (40-20) | 60-53 | Won 3 |
| » W: Denny Lemaster (9-11) L: Gary Waslewski (2-6) | Fifth | 4½ out |
| Monday, August 11 |
| » Defeated Mets (62-49), 3-0 | Astrodome (41-20) | 61-53 | Won 4 |
| » W: Tom Griffin (8-5) L: Jim McAndrew (3-5) S: Fred Gladding (24) | Fourth | 4½ out |
| Tuesday, August 12 |
| » Defeated Mets (62-50), 8-7 | Astrodome (42-20) | 62-53 | Won 5 |
| » W: Don Wilson (15-7) L: Jerry Koosman (9-8) S: Fred Gladding (25) | Fourth | 3 out |
| Wednesday, August 13 |
| » Defeated Mets (62-51), 8-2 | Astrodome (43-20) | 63-53 | Won 6 |
| » W: Larry Dierker (14-9) L: Gary Gentry (9-10) | Third | 3 out |
| Friday, August 15 |
| » Lost to Phillies (47-69), 1-0 | Shibe Park (2-2) | 63-54 | |
| » W: Grant Jackson (12-11) L: Denny Lemaster (9-12) | Fourth | 2½ out |
| Saturday, August 16 |
| » Lost to Phillies (48-69), 7-0 | Shibe Park (2-3) | 63-55 | Lost 2 |
| » W: Rick Wise (10-10) L: Tom Griffin (8-6) | Fifth | 3½ out |
| Sunday, August 17 |
| » Defeated Phillies (48-70), 3-2 | Shibe Park (3-3) | 64-55 | |
| » W: Larry Dierker (15-9) L: Bill Champion (4-6) S: Fred Gladding (26) | Third | 2½ out |
| Tuesday, August 19 |
| » Lost to Pirates (63-56), 5-1 | Forbes Field (1-4) | 64-56 | |
| » W: Luke Walker (2-3) L: Don Wilson (15-8) S: Joe Gibbon (9) | Third | 3 out |
| Wednesday, August 20 |
| » Lost to Pirates (64-56), 1-0 | Forbes Field (1-5) | 64-57 | Lost 2 |
| » W: Bob Veale (9-11) L: Denny Lemaster (9-13) | Fourth | 3½ out |
| Thursday, August 21 |
| Future Astro Andujar Cedeno is born in La Romana, D.R. |
| Friday, August 22 |
| » Defeated Cubs (76-48), 8-2 | Wrigley Field (1-2) | 65-57 | |
| » W: Larry Dierker (16-9) L: Dick Selma (12-5) | Fifth | 2 out |
| Saturday, August 23 |
| » Lost to Cubs (77-48), 11-5 | Wrigley Field (1-3) | 65-58 | |
| » W: Ken Holtzman (15-7) L: Fred Gladding (2-4) | Fifth | 2 out |
| Sunday, August 24 |
| » Lost to Cubs (78-48), 10-9 | Wrigley Field (1-4) | 65-59 | Lost 2 |
| » W: Phil Regan (12-5) L: Fred Gladding (2-5) S: Hank Aguirre (1) | Fifth | 2½ out |
| » Defeated Cubs (78-49), 3-2 | Wrigley Field (2-4) | 66-59 | |
| » W: Don Wilson (16-8) L: Ken Johnson (1-4) | Fifth | 2½ out |
| Tuesday, August 26 |
| » Lost to Cardinals (70-57), 1-0 | Busch Stadium II (1-2) | 66-60 | |
| » W: Nelson Briles (13-11) L: Larry Dierker (16-10) | Fifth | 3 out |
| » Defeated Cardinals (70-58), 4-2 | Busch Stadium II (2-2) | 67-60 | |
| » W: Denny Lemaster (10-13) L: Joe Hoerner (1-3) | Fifth | 3 out |
| Wednesday, August 27 |
| » Defeated Cardinals (70-59), 5-1 | Busch Stadium II (3-2) | 68-60 | Won 2 |
| » W: Tom Griffin (9-6) L: Bob Gibson (16-9) S: Fred Gladding (27) | Fifth | 3 out |
| Thursday, August 28 |
| » Lost to Cardinals (71-59), 2-1 | Busch Stadium II (3-3) | 68-61 | |
| » W: Mudcat Grant (7-10) L: Don Wilson (16-9) | Fifth | 4 out |
| Friday, August 29 |
| » Lost to Pirates (69-59), 4-2 | Astrodome (43-21) | 68-62 | Lost 2 |
| » W: Bob Moose (9-2) L: Jim Bouton (2-2) | Fifth | 5 out |
| Saturday, August 30 |
| » Defeated Pirates (69-60), 2-1 | Astrodome (44-21) | 69-62 | |
| » W: Larry Dierker (17-10) L: Bo Belinsky (0-1) | Fifth | 4 out |
| Sunday, August 31 |
| » Lost to Pirates (70-60), 6-4 | Astrodome (44-22) | 69-63 | |
| » W: Lou Marone (1-1) L: Fred Gladding (2-6) S: Steve Blass (2) | Fifth | 4½ out |
| Monday, September 1 |
| » Lost to Cardinals (72-62), 6-2 | Astrodome (44-23) | 69-64 | Lost 2 |
| » W: Steve Carlton (16-7) L: Don Wilson (16-10) S: Mudcat Grant (3) | Fifth | 5½ out |
| Tuesday, September 2 |
| » Defeated Cardinals (72-63), 7-6 | Astrodome (45-23) | 70-64 | |
| » W: Fred Gladding (3-6) L: Mudcat Grant (7-11) | Fifth | 5 out |
| Friday, September 5 |
| » Defeated Giants (76-60), 2-0 | Astrodome (46-23) | 71-64 | Won 2 |
| » W: Larry Dierker (18-10) L: Gaylord Perry (16-12) | Fifth | 4½ out |
| Saturday, September 6 |
| » Lost to Giants (77-60), 7-6 | Astrodome (46-24) | 71-65 | |
| » W: Ron Bryant (3-1) L: Denny Lemaster (10-14) S: Don McMahon (12) | Fifth | 5½ out |
| Sunday, September 7 |
| » Defeated Giants (77-61), 7-6 | Astrodome (47-24) | 72-65 | |
| » W: Jack Billingham (6-6) L: Mike McCormick (9-9) | Fifth | 4½ out |
| Monday, September 8 |
| » Defeated Padres (44-96), 9-2 | Astrodome (48-24) | 73-65 | Won 2 |
| » W: Tom Griffin (10-6) L: Mike Corkins (0-1) | Fifth | 3½ out |
| » Major-league debuts: Mike Corkins and Fred Kendall (Padres) |
| Tuesday, September 9 |
| » Defeated Padres (44-97), 9-2 | Astrodome (49-24) | 74-65 | Won 3 |
| » W: Larry Dierker (19-10) L: Joe Niekro (8-14) | Fifth | 3 out |
| Wednesday, September 10 |
| » Defeated Dodgers (75-65), 8-1 | Astrodome (50-24) | 75-65 | Won 4 |
| » W: Denny Lemaster (11-14) L: Don Sutton (15-15) | Fourth | 2 out |
| Thursday, September 11 |
| » Lost to Dodgers (76-65), 1-0 | Astrodome (50-25) | 75-66 | |
| » W: Claude Osteen (19-12) L: Don Wilson (16-11) | Fifth | 2½ out |
| Friday, September 12 |
| » Lost to Braves (80-65), 4-3 | Atlanta-Fulton County Stadium (1-6) | 75-67 | Lost 2 |
| » W: George Stone (12-9) L: Tom Griffin (10-7) S: Hoyt Wilhelm (12) | Fifth | 3½ out |
| Saturday, September 13 |
| » Lost to Braves (81-65), 3-2 | Atlanta-Fulton County Stadium (1-7) | 75-68 | Lost 3 |
| » W: Paul Doyle (2-0) L: Fred Gladding (3-7) | Fifth | 4½ out |
| » Major-league debuts: Jim Breazeale (Braves) |
| Sunday, September 14 |
| » Lost to Braves (82-65), 3-2 | Atlanta-Fulton County Stadium (1-8) | 75-69 | Lost 4 |
| » W: Hoyt Wilhelm (6-7) L: Denny Lemaster (11-15) | Fifth | 5½ out |
| Monday, September 15 |
| » Lost to Padres (46-101), 5-3 | San Diego/Jack Murphy Stadium (2-6) | 75-70 | Lost 5 |
| » W: Mike Corkins (1-1) L: Don Wilson (16-12) S: Dave Roberts (1) | Fifth | 5½ out |
| Tuesday, September 16 |
| » Lost to Padres (47-101), 8-1 | San Diego/Jack Murphy Stadium (2-7) | 75-71 | Lost 6 |
| » W: Tommie Sisk (2-11) L: Tom Griffin (10-8) | Fifth | 6 out |
| » Major-league debuts: Scipio Spinks (Astros) |
| Wednesday, September 17 |
| » Defeated Giants (82-67), 2-1 | Candlestick Park (2-6) | 76-71 | |
| » W: Larry Dierker (20-10) L: Gaylord Perry (17-14) S: Jim Bouton (2) | Fifth | 5½ out |
| Thursday, September 18 |
| » Lost to Giants (83-67), 9-3 | Candlestick Park (2-7) | 76-72 | |
| » W: Ron Bryant (4-2) L: Denny Lemaster (11-16) S: Don McMahon (13) | Fifth | 6 out |
| Friday, September 19 |
| » Defeated Reds (80-69), 3-2 | Astrodome (51-25) | 77-72 | |
| » W: Fred Gladding (4-7) L: Wayne Granger (8-6) | Fifth | 6 out |
| Saturday, September 20 |
| » Defeated Reds (80-70), 6-0 | Astrodome (52-25) | 78-72 | Won 2 |
| » W: Tom Griffin (11-8) L: Tony Cloninger (10-17) | Fifth | 6 out |
| Sunday, September 21 |
| » Lost to Reds (81-70), 4-1 | Astrodome (52-26) | 78-73 | |
| » W: Gary Nolan (8-6) L: Denny Lemaster (11-17) S: Wayne Granger (24) | Fifth | 7 out |
| Monday, September 22 |
| » Lost to Braves (87-68), 5-3 | Astrodome (52-27) | 78-74 | Lo |