| Sunday, January 14 |
| Former White Sox Bill Black dies in Philadelphia, PA at the age of 69. |
| Tuesday, January 16 |
| Former White Sox Liz Funk dies in Norman, OK at the age of 64. |
| Tuesday, January 23 |
| Former White Sox Patsy Flaherty dies in Alexandria, LA at the age of 92. |
| Friday, February 23 |
| Former White Sox Hank Schreiber dies in Indianapolis, IN at the age of 77. |
| Thursday, February 29 |
| Former White Sox Lena Blackburne dies in Riverside, NJ at the age of 82. |
| Sunday, March 3 |
| Future White Sox Scott Radinsky is born in Glendale, CA. |
| Wednesday, March 20 |
| Former White Sox Clyde Shoun dies in Mountain Home, TN at the age of 57. |
| Sunday, March 31 |
| Former White Sox Grover Lowdermilk dies in Odin, IL at the age of 84. |
| Wednesday, April 10 |
| » Lost to Indians (1-0), 9-0 | Comiskey Park I (0-1) | 0-1 | |
| » W: Sonny Siebert (1-0) L: Joe Horlen (0-1) | Second | 1 out |
| Saturday, April 13 |
| » Lost to Tigers (2-1), 5-2 | Tiger Stadium (0-1) | 0-2 | Lost 2 |
| » W: Daryl Patterson (1-0) L: Gary Peters (0-1) S: Fred Lasher (1) | Sixth | 2½ out |
| Sunday, April 14 |
| » Lost to Tigers (3-1), 5-4 | Tiger Stadium (0-2) | 0-3 | Lost 3 |
| » W: Fred Lasher (1-0) L: Bob Locker (0-1) | Seventh | 3½ out |
| Tuesday, April 16 |
| » Lost to Indians (3-2), 3-1 | Cleveland Stadium (0-1) | 0-4 | Lost 4 |
| » W: Luis Tiant (1-1) L: Joe Horlen (0-2) | Seventh | 4½ out |
| Wednesday, April 17 |
| » Lost to Red Sox (3-3), 2-0 | Fenway Park (0-1) | 0-5 | Lost 5 |
| » W: Dick Ellsworth (2-0) L: Cisco Carlos (0-1) | Sixth | 5½ out |
| Thursday, April 18 |
| » Lost to Red Sox (4-3), 3-0 | Fenway Park (0-2) | 0-6 | Lost 6 |
| » W: Jose Santiago (1-0) L: Gary Peters (0-2) | Sixth | 5½ out |
| Saturday, April 20 |
| » Lost to Tigers (7-1), 4-1 | Comiskey Park I (0-2) | 0-7 | Lost 7 |
| » W: Jon Warden (3-0) L: Wilbur Wood (0-1) S: Dennis Ribant (1) | Eighth | 6½ out |
| Sunday, April 21 |
| » Lost to Tigers (8-1), 4-1 | Comiskey Park I (0-3) | 0-8 | Lost 8 |
| » W: Earl Wilson (2-1) L: Joe Horlen (0-3) | Eighth | 8½ out |
| » Lost to Tigers (9-1), 4-2 | Comiskey Park I (0-4) | 0-9 | Lost 9 |
| » W: Denny McLain (1-0) L: Cisco Carlos (0-2) | Eighth | 8½ out |
| Thursday, April 25 |
| » Lost to Twins (8-4), 3-2 | Metropolitan Stadium (0-1) | 0-10 | Lost 10 |
| » W: Jim Perry (2-1) L: Gary Peters (0-3) S: Al Worthington (3) | Ninth | 8½ out |
| Friday, April 26 |
| » Defeated Twins (8-5), 3-2 | Metropolitan Stadium (1-1) | 1-10 | |
| » W: Tommy John (1-0) L: Dave Boswell (2-1) S: Wilbur Wood (1) | Tenth | 7½ out |
| Saturday, April 27 |
| » Lost to Twins (9-5), 4-1 | Metropolitan Stadium (1-2) | 1-11 | |
| » W: Jim Merritt (3-1) L: Joe Horlen (0-4) | Tenth | 8½ out |
| Sunday, April 28 |
| » Defeated Twins (9-6), 3-2 | Metropolitan Stadium (2-2) | 2-11 | |
| » W: Bob Locker (1-1) L: Dean Chance (2-3) | Ninth | 8 out |
| Tuesday, April 30 |
| » Lost to Senators (11-7), 5-4 | Comiskey Park I (0-5) | 2-12 | |
| » W: Bob Humphreys (1-0) L: Bob Priddy (0-1) | Ninth | 8½ out |
| Wednesday, May 1 |
| » Defeated Senators (11-8), 4-1 | Comiskey Park I (1-5) | 3-12 | |
| » W: Tommy John (2-0) L: Frank Bertaina (1-1) | Tenth | 8½ out |
| Friday, May 3 |
| » Lost to Yankees (9-11), 3-2 | Comiskey Park I (1-6) | 3-13 | |
| » W: Bill Monbouquette (4-1) L: Joe Horlen (0-5) | Ninth | 8½ out |
| Saturday, May 4 |
| » Defeated Yankees (9-12), 4-1 | Comiskey Park I (2-6) | 4-13 | |
| » W: Cisco Carlos (1-2) L: Fred Talbot (0-3) S: Bob Locker (1) | Ninth | 8½ out |
| » Major-league debuts: Bill Melton (White Sox) |
| Sunday, May 5 |
| » Defeated Yankees (9-13), 5-1 | Comiskey Park I (3-6) | 5-13 | Won 2 |
| » W: Gary Peters (1-3) L: Al Downing (0-1) | Ninth | 9 out |
| » Lost to Yankees (10-13), 4-1 | Comiskey Park I (3-7) | 5-14 | |
| » W: Stan Bahnsen (2-1) L: Jack Fisher (0-1) S: Joe Verbanic (2) | Ninth | 9 out |
| Monday, May 6 |
| » Defeated Angels (11-13), 5-1 | Anaheim Stadium (1-0) | 6-14 | |
| » W: Tommy John (3-0) L: Rickey Clark (0-2) | Eighth | 9 out |
| Tuesday, May 7 |
| » Defeated Angels (11-14), 6-4 | Anaheim Stadium (2-0) | 7-14 | Won 2 |
| » W: Joe Horlen (1-5) L: Sammy Ellis (1-4) S: Bob Locker (2) | Tenth | 8 out |
| Wednesday, May 8 |
| » Lost to Angels (12-14), 3-2 | Anaheim Stadium (2-1) | 7-15 | |
| » W: Clyde Wright (2-0) L: Cisco Carlos (1-3) S: Jack Hamilton (2) | Ninth | 8 out |
| Thursday, May 9 |
| » Defeated Athletics (13-13), 4-2 | Oakland-Alameda County Stadium (1-0) | 8-15 | |
| » W: Gary Peters (2-3) L: Lew Krausse (1-4) S: Bob Locker (3) | Tenth | 7½ out |
| Friday, May 10 |
| » Defeated Athletics (13-14), 2-1 | Oakland-Alameda County Stadium (2-0) | 9-15 | Won 2 |
| » W: Bob Locker (2-1) L: Chuck Dobson (2-2) S: Wilbur Wood (2) | Tenth | 7 out |
| Saturday, May 11 |
| » Defeated Athletics (13-15), 1-0 | Oakland-Alameda County Stadium (3-0) | 10-15 | Won 3 |
| » W: Joe Horlen (2-5) L: Jim Nash (1-3) S: Bob Locker (4) | Ninth | 7 out |
| Sunday, May 12 |
| » Lost to Athletics (14-15), 6-2 | Oakland-Alameda County Stadium (3-1) | 10-16 | |
| » W: Tony Pierce (1-0) L: Cisco Carlos (1-4) S: Jack Aker (4) | Eighth | 7 out |
| Tuesday, May 14 |
| » Defeated Angels (14-18), 7-6 | Comiskey Park I (4-7) | 11-16 | |
| » W: Wilbur Wood (1-1) L: Minnie Rojas (1-3) | Tenth | 7 out |
| » Major-league debuts: Marty Pattin (Angels) |
| Future White Sox Mark Dalesandro is born in Chicago, IL. |
| Wednesday, May 15 |
| » Lost to Angels (15-18), 4-2 | County Stadium (0-1) | 11-17 | |
| » W: George Brunet (4-3) L: Bob Locker (2-2) S: Jim McGlothlin (1) | Ninth | 7 out |
| Friday, May 17 |
| » Defeated Athletics (15-17), 1-0 | Comiskey Park I (5-7) | 12-17 | |
| » W: Joe Horlen (3-5) L: Jim Nash (1-4) | Eighth | 7 out |
| Saturday, May 18 |
| » Defeated Athletics (15-18), 4-2 | Comiskey Park I (6-7) | 13-17 | Won 2 |
| » W: Hoyt Wilhelm (1-0) L: Lew Krausse (1-5) S: Wilbur Wood (3) | Sixth | 6 out |
| Sunday, May 19 |
| » Defeated Athletics (15-19), 6-2 | Comiskey Park I (7-7) | 14-17 | Won 3 |
| » W: Tommy John (4-0) L: Catfish Hunter (4-3) | Fourth | 6 out |
| » Defeated Athletics (15-20), 7-3 | Comiskey Park I (8-7) | 15-17 | Won 4 |
| » W: Cisco Carlos (2-4) L: Tony Pierce (1-1) S: Wilbur Wood (4) | Fourth | 6 out |
| Monday, May 20 |
| » Lost to Orioles (19-16), 2-1 | Memorial Stadium (0-1) | 15-18 | |
| » W: Jim Hardin (5-1) L: Jack Fisher (0-2) | Sixth | 7 out |
| Tuesday, May 21 |
| » Defeated Orioles (19-17), 2-1 | Memorial Stadium (1-1) | 16-18 | |
| » W: Bob Locker (3-2) L: Eddie Watt (1-3) S: Hoyt Wilhelm (1) | Sixth | 6 out |
| Wednesday, May 22 |
| » Lost to Senators (16-22), 2-0 | Robert F. Kennedy Stadium (0-1) | 16-19 | |
| » W: Frank Bertaina (3-2) L: Gary Peters (2-4) S: Dave Baldwin (5) | Sixth | 6 out |
| Future White Sox Al Levine is born in Park Ridge, IL. |
| Friday, May 24 |
| » Lost to Yankees (17-22), 1-0 | Yankee Stadium (0-1) | 16-20 | Lost 2 |
| » W: Joe Verbanic (2-2) L: Wilbur Wood (1-2) | Sixth | 6½ out |
| Saturday, May 25 |
| » Lost to Yankees (18-22), 1-0 | Yankee Stadium (0-2) | 16-21 | Lost 3 |
| » W: Fritz Peterson (2-2) L: Bob Locker (3-3) | Ninth | 7½ out |
| Sunday, May 26 |
| » Lost to Yankees (19-22), 5-1 | Yankee Stadium (0-3) | 16-22 | Lost 4 |
| » W: Mel Stottlemyre (6-3) L: Gary Peters (2-5) | Eighth | 8 out |
| » Lost to Yankees (20-22), 7-6 | Yankee Stadium (0-4) | 16-23 | Lost 5 |
| » W: Bill Monbouquette (5-3) L: Cisco Carlos (2-5) S: Steve Hamilton (2) | Eighth | 8 out |
| » Major-league debuts: Ellie Rodriguez (Yankees) |
| Monday, May 27 |
| Future White Sox Frank Thomas is born in Columbus, GA. |
| Tuesday, May 28 |
| » Lost to Orioles (25-17), 3-2 | County Stadium (0-2) | 16-24 | Lost 6 |
| » W: Pete Richert (1-1) L: Hoyt Wilhelm (1-1) | Ninth | 8½ out |
| Wednesday, May 29 |
| » Defeated Orioles (25-18), 3-1 | Comiskey Park I (9-7) | 17-24 | |
| » W: Joe Horlen (4-5) L: Dave McNally (4-5) | Ninth | 8½ out |
| Thursday, May 30 |
| » Lost to Orioles (26-18), 5-0 | Comiskey Park I (9-8) | 17-25 | |
| » W: Dave Leonhard (3-2) L: Bob Priddy (0-2) | Seventh | 9½ out |
| Friday, May 31 |
| » Defeated Twins (24-21), 2-1 | Comiskey Park I (10-8) | 18-25 | |
| » W: Don McMahon (1-0) L: Bob Miller (0-1) | Eighth | 9½ out |
| Saturday, June 1 |
| » Defeated Twins (24-22), 1-0 | Comiskey Park I (11-8) | 19-25 | Won 2 |
| » W: Wilbur Wood (2-2) L: Dean Chance (4-6) | Ninth | 9½ out |
| Sunday, June 2 |
| » Defeated Twins (24-23), 3-2 | Comiskey Park I (12-8) | 20-25 | Won 3 |
| » W: Jack Fisher (1-2) L: Jim Perry (5-4) S: Wilbur Wood (5) | Seventh | 8½ out |
| » Defeated Twins (24-24), 4-3 | Comiskey Park I (13-8) | 21-25 | Won 4 |
| » W: Wilbur Wood (3-2) L: Ron Perranoski (4-1) | Seventh | 8½ out |
| Monday, June 3 |
| » Lost to Indians (28-22), 3-2 | Cleveland Stadium (0-2) | 21-26 | |
| » W: Hal Kurtz (1-0) L: Jack Fisher (1-3) | Eighth | 8½ out |
| Tuesday, June 4 |
| » Lost to Indians (29-22), 2-1 | Cleveland Stadium (0-3) | 21-27 | Lost 2 |
| » W: Luis Tiant (8-4) L: Gary Peters (2-6) | Ninth | 9 out |
| Wednesday, June 5 |
| » Lost to Indians (30-22), 1-0 | Cleveland Stadium (0-4) | 21-28 | Lost 3 |
| » W: Stan Williams (4-3) L: Cisco Carlos (2-6) S: Hal Kurtz (1) | Ninth | 10 out |
| Thursday, June 6 |
| » Lost to Indians (31-22), 2-1 | Cleveland Stadium (0-5) | 21-29 | Lost 4 |
| » W: Billy Rohr (1-0) L: Don McMahon (1-1) | Tenth | 11 out |
| Friday, June 7 |
| » Lost to Red Sox (26-27), 3-2 | Fenway Park (0-3) | 21-30 | Lost 5 |
| » W: Jose Santiago (7-3) L: Joe Horlen (4-6) | Tenth | 12 out |
| Saturday, June 8 |
| » Defeated Red Sox (26-28), 4-0 | Fenway Park (1-3) | 22-30 | |
| » W: Gary Peters (3-6) L: Gary Bell (5-2) | Tenth | 12 out |
| Monday, June 10 |
| » Defeated Yankees (26-31), 5-2 | Yankee Stadium (1-4) | 23-30 | Won 2 |
| » W: Wilbur Wood (4-2) L: Dooley Womack (0-5) S: Bob Locker (5) | Tenth | 11 out |
| Tuesday, June 11 |
| » Defeated Yankees (26-32), 9-5 | Yankee Stadium (2-4) | 24-30 | Won 3 |
| » W: Joe Horlen (5-6) L: Fred Talbot (0-8) S: Wilbur Wood (6) | Eighth | 11½ out |
| Friday, June 14 |
| » Lost to Tigers (40-20), 6-5 | Comiskey Park I (13-9) | 24-31 | |
| » W: John Hiller (5-1) L: Bob Priddy (0-3) | Eighth | 13½ out |
| Saturday, June 15 |
| » Defeated Tigers (40-21), 7-4 | Comiskey Park I (14-9) | 25-31 | |
| » W: Tommy John (5-0) L: Joe Sparma (5-6) S: Wilbur Wood (7) | Eighth | 12½ out |
| Sunday, June 16 |
| » Defeated Tigers (40-22), 3-2 | Comiskey Park I (15-9) | 26-31 | Won 2 |
| » W: Hoyt Wilhelm (2-1) L: Mickey Lolich (5-4) S: Wilbur Wood (8) | Ninth | 12½ out |
| » Lost to Tigers (41-22), 6-1 | Comiskey Park I (15-10) | 26-32 | |
| » W: Denny McLain (11-2) L: Cisco Carlos (2-7) S: Pat Dobson (1) | Ninth | 12½ out |
| Monday, June 17 |
| » Defeated Indians (33-31), 2-1 | County Stadium (1-2) | 27-32 | |
| » W: Jack Fisher (2-3) L: Steve Hargan (4-7) S: Bob Locker (6) | Eighth | 12 out |
| Tuesday, June 18 |
| » Lost to Indians (34-31), 4-1 | Comiskey Park I (15-11) | 27-33 | |
| » W: Sam McDowell (7-5) L: Gary Peters (3-7) S: Stan Williams (2) | Ninth | 13 out |
| Wednesday, June 19 |
| » Lost to Indians (35-31), 3-1 | Comiskey Park I (15-12) | 27-34 | Lost 2 |
| » W: Luis Tiant (10-5) L: Bob Locker (3-4) | Ninth | 13 out |
| Thursday, June 20 |
| » Defeated Indians (35-32), 8-4 | Comiskey Park I (16-12) | 28-34 | |
| » W: Tommy John (6-0) L: Mike Paul (0-3) S: Wilbur Wood (9) | Ninth | 13 out |
| Friday, June 21 |
| » Lost to Red Sox (31-31), 6-3 | Comiskey Park I (16-13) | 28-35 | |
| » W: Ray Culp (4-2) L: Joe Horlen (5-7) S: Bill Landis (1) | Ninth | 12½ out |
| » Defeated Red Sox (31-32), 10-4 | Comiskey Park I (17-13) | 29-35 | |
| » W: Cisco Carlos (3-7) L: Jerry Stephenson (1-5) S: Hoyt Wilhelm (2) | Ninth | 12½ out |
| Saturday, June 22 |
| » Lost to Red Sox (32-32), 7-2 | Comiskey Park I (17-14) | 29-36 | |
| » W: Jose Santiago (8-4) L: Gary Peters (3-8) | Ninth | 12½ out |
| Sunday, June 23 |
| » Lost to Red Sox (33-32), 6-2 | Comiskey Park I (17-15) | 29-37 | Lost 2 |
| » W: Gary Bell (6-2) L: Jack Fisher (2-4) | Ninth | 12½ out |
| » Defeated Red Sox (33-33), 10-1 | Comiskey Park I (18-15) | 30-37 | |
| » W: Wilbur Wood (5-2) L: Jim Lonborg (0-2) S: Hoyt Wilhelm (3) | Ninth | 12½ out |
| Monday, June 24 |
| » Lost to Twins (36-33), 1-0 | County Stadium (1-3) | 30-38 | |
| » W: Dean Chance (7-8) L: Bob Priddy (0-4) | Ninth | 13½ out |
| Friday, June 28 |
| » Lost to Tigers (47-26), 5-4 | Tiger Stadium (0-3) | 30-39 | Lost 2 |
| » W: Fred Lasher (5-1) L: Wilbur Wood (5-3) | Ninth | 15 out |
| Saturday, June 29 |
| » Lost to Tigers (48-26), 5-2 | Tiger Stadium (0-4) | 30-40 | Lost 3 |
| » W: Denny McLain (14-2) L: Cisco Carlos (3-8) | Ninth | 16 out |
| » Major-league debuts: Gail Hopkins (White Sox) |
| Sunday, June 30 |
| » Defeated Tigers (48-27), 12-0 | Tiger Stadium (1-4) | 31-40 | |
| » W: Tommy John (7-0) L: Joe Sparma (6-8) | Ninth | 15 out |
| » Major-league debuts: Jim Rooker (Tigers) |
| Monday, July 1 |
| » Defeated Orioles (38-35), 6-3 | Memorial Stadium (2-1) | 32-40 | Won 2 |
| » W: Wilbur Wood (6-3) L: Dave McNally (8-7) S: Bob Locker (7) | Ninth | 15 out |
| Wednesday, July 3 |
| » Lost to Orioles (39-35), 3-1 | Memorial Stadium (2-2) | 32-41 | |
| » W: Jim Hardin (9-4) L: Hoyt Wilhelm (2-2) | Ninth | 17 out |
| » Lost to Orioles (40-35), 1-0 | Memorial Stadium (2-3) | 32-42 | Lost 2 |
| » W: Tom Phoebus (7-8) L: Gary Peters (3-9) | Ninth | 17 out |
| Thursday, July 4 |
| » Lost to Orioles (41-35), 4-3 | Memorial Stadium (2-4) | 32-43 | Lost 3 |
| » W: Eddie Watt (4-4) L: Wilbur Wood (6-4) | Ninth | 18 out |
| Friday, July 5 |
| » Defeated Senators (29-46), 4-2 | Robert F. Kennedy Stadium (1-1) | 33-43 | |
| » W: Bob Priddy (1-4) L: Bruce Howard (0-4) S: Wilbur Wood (10) | Ninth | 18 out |
| Saturday, July 6 |
| » Lost to Senators (30-46), 8-4 | Robert F. Kennedy Stadium (1-2) | 33-44 | |
| » W: Joe Coleman (5-9) L: Jack Fisher (2-5) | Ninth | 18 out |
| Sunday, July 7 |
| » Defeated Senators (30-47), 4-3 | Robert F. Kennedy Stadium (2-2) | 34-44 | |
| » W: Don McMahon (2-1) L: Bob Humphreys (2-1) | Eighth | 18½ out |
| Thursday, July 11 |
| » Lost to Yankees (37-43), 5-4 | County Stadium (1-4) | 34-45 | |
| » W: Fritz Peterson (6-3) L: Gary Peters (3-10) S: Steve Hamilton (6) | Eighth | 18½ out |
| Friday, July 12 |
| » Lost to Yankees (38-43), 2-1 | Comiskey Park I (18-16) | 34-46 | Lost 2 |
| » Manager: Les Moss |
| » W: Steve Barber (2-3) L: Tommy John (7-1) | Eighth | 19½ out |
| Former White Sox Kettle Wirts dies in Sacramento, CA at the age of 71. |
| Saturday, July 13 |
| » Lost to Yankees (39-43), 4-2 | Comiskey Park I (18-17) | 34-47 | Lost 3 |
| » W: Mel Stottlemyre (12-5) L: Joe Horlen (5-8) S: Steve Hamilton (7) | Ninth | 19½ out |
| Sunday, July 14 |
| » Defeated Senators (30-51), 7-2 | Comiskey Park I (19-17) | 35-47 | |
| » Manager: Al Lopez |
| » W: Jack Fisher (3-5) L: Phil Ortega (4-8) | Eighth | 18 out |
| » Defeated Senators (30-52), 6-5 | Comiskey Park I (20-17) | 36-47 | Won 2 |
| » W: Bob Locker (4-4) L: Bob Humphreys (2-2) | Eighth | 18 out |
| Monday, July 15 |
| » Defeated Senators (30-53), 3-2 | Comiskey Park I (21-17) | 37-47 | Won 3 |
| » W: Cisco Carlos (4-8) L: Frank Bertaina (4-6) S: Hoyt Wilhelm (4) | Eighth | 17 out |
| Tuesday, July 16 |
| » Lost to Orioles (49-37), 4-2 | Comiskey Park I (21-18) | 37-48 | |
| » W: Jim Hardin (11-5) L: Tommy John (7-2) | Eighth | 18 out |
| Wednesday, July 17 |
| » Defeated Orioles (49-38), 1-0 | Comiskey Park I (22-18) | 38-48 | |
| » W: Joe Horlen (6-8) L: Tom Phoebus (9-9) S: Hoyt Wilhelm (5) | Ninth | 17 out |
| Thursday, July 18 |
| » Defeated Orioles (49-39), 2-1 | Comiskey Park I (23-18) | 39-48 | Won 2 |
| » W: Jack Fisher (4-5) L: Dave Leonhard (5-4) S: Hoyt Wilhelm (6) | Ninth | 17 out |
| Friday, July 19 |
| » Lost to Angels (43-47), 2-0 | Comiskey Park I (23-19) | 39-49 | |
| » W: George Brunet (10-9) L: Bob Priddy (1-5) | Eighth | 18 out |
| Saturday, July 20 |
| » Lost to Angels (44-47), 7-6 | Comiskey Park I (23-20) | 39-50 | Lost 2 |
| » W: Marty Pattin (3-2) L: Wilbur Wood (6-5) S: Minnie Rojas (6) | Ninth | 18 out |
| Sunday, July 21 |
| » Defeated Angels (44-48), 5-1 | Comiskey Park I (24-20) | 40-50 | |
| » W: Joe Horlen (7-8) L: Jim McGlothlin (6-8) S: Hoyt Wilhelm (7) | Eighth | 17 out |
| » Lost to Angels (45-48), 7-0 | Comiskey Park I (24-21) | 40-51 | |
| » W: Clyde Wright (7-2) L: Cisco Carlos (4-9) | Eighth | 17 out |
| Monday, July 22 |
| » Lost to Athletics (46-49), 4-0 | County Stadium (1-5) | 40-52 | Lost 2 |
| » W: Catfish Hunter (8-8) L: Jack Fisher (4-6) | Ninth | 17½ out |
| Wednesday, July 24 |
| » Lost to Athletics (47-49), 1-0 | Comiskey Park I (24-22) | 40-53 | Lost 3 |
| » Manager: Les Moss |
| » W: Jim Nash (7-6) L: Tommy John (7-3) | Eighth | 18½ out |
| » Lost to Athletics (48-49), 2-1 | Comiskey Park I (24-23) | 40-54 | Lost 4 |
| » W: Blue Moon Odom (9-6) L: Hoyt Wilhelm (2-3) | Eighth | 18½ out |
| Friday, July 26 |
| » Defeated Angels (47-51), 3-1 | Anaheim Stadium (3-1) | 41-54 | |
| » W: Joe Horlen (8-8) L: Clyde Wright (7-3) S: Wilbur Wood (11) | Eighth | 19 out |
| Saturday, July 27 |
| » Defeated Angels (47-52), 1-0 | Anaheim Stadium (4-1) | 42-54 | Won 2 |
| » W: Bob Priddy (2-5) L: George Brunet (11-10) S: Wilbur Wood (12) | Ninth | 19 out |
| Sunday, July 28 |
| » Defeated Angels (47-53), 2-1 | Anaheim Stadium (5-1) | 43-54 | Won 3 |
| » W: Jack Fisher (5-6) L: Tom Murphy (2-4) S: Wilbur Wood (13) | Ninth | 18 out |
| Monday, July 29 |
| » Defeated Athletics (50-51), 7-2 | Oakland-Alameda County Stadium (4-1) | 44-54 | Won 4 |
| » W: Wilbur Wood (7-5) L: Blue Moon Odom (9-7) | Eighth | 17 out |
| Tuesday, July 30 |
| » Lost to Athletics (51-51), 3-1 | Oakland-Alameda County Stadium (4-2) | 44-55 | |
| » W: Chuck Dobson (8-11) L: Joe Horlen (8-9) S: Jack Aker (9) | Eighth | 18 out |
| Wednesday, July 31 |
| » Defeated Twins (48-54), 12-8 | Metropolitan Stadium (3-2) | 45-55 | |
| » W: Wilbur Wood (8-5) L: Al Worthington (2-5) S: Hoyt Wilhelm (8) | Ninth | 18 out |
| Thursday, August 1 |
| » Lost to Twins (49-54), 4-1 | Metropolitan Stadium (3-3) | 45-56 | |
| » W: Jim Perry (8-6) L: Jack Fisher (5-7) S: Dean Chance (1) | Ninth | 18 out |
| Friday, August 2 |
| » Lost to Senators (38-64), 11-6 | County Stadium (1-6) | 45-57 | Lost 2 |
| » W: Camilo Pascual (10-5) L: Tommy John (7-4) | Ninth | 19 out |
| Saturday, August 3 |
| » Lost to Senators (39-64), 3-1 | Comiskey Park I (24-24) | 45-58 | Lost 3 |
| » W: Jim Hannan (6-2) L: Joe Horlen (8-10) S: Barry Moore (3) | Ninth | 18½ out |
| » Defeated Senators (39-65), 6-2 | Comiskey Park I (25-24) | 46-58 | |
| » W: Bob Priddy (3-5) L: Phil Ortega (4-10) | Ninth | 18½ out |
| Sunday, August 4 |
| » Defeated Senators (39-66), 7-2 | Comiskey Park I (26-24) | 47-58 | Won 2 |
| » W: Jack Fisher (6-7) L: Dick Bosman (1-7) S: Wilbur Wood (14) | Ninth | 18½ out |
| Monday, August 5 |
| » Lost to Red Sox (58-51), 2-1 | Comiskey Park I (26-25) | 47-59 | |
| » W: Bill Landis (3-2) L: Tommy John (7-5) | Ninth | 19 out |
| Tuesday, August 6 |
| » Lost to Red Sox (59-51), 8-2 | Comiskey Park I (26-26) | 47-60 | Lost 2 |
| » W: Jim Lonborg (3-3) L: Cisco Carlos (4-10) S: Sparky Lyle (9) | Ninth | 20 out |
| Wednesday, August 7 |
| » Lost to Red Sox (60-51), 3-2 | Comiskey Park I (26-27) | 47-61 | Lost 3 |
| » W: Dick Ellsworth (11-6) L: Bob Priddy (3-6) | Ninth | 21½ out |
| Thursday, August 8 |
| » Lost to Red Sox (61-51), 1-0 | County Stadium (1-7) | 47-62 | Lost 4 |
| » W: Ray Culp (8-4) L: Joe Horlen (8-11) | Ninth | 22½ out |
| Friday, August 9 |
| » Defeated Indians (60-56), 1-0 | Comiskey Park I (27-27) | 48-62 | |
| » W: Tommy John (8-5) L: Steve Hargan (7-12) S: Hoyt Wilhelm (9) | Ninth | 21½ out |
| Saturday, August 10 |
| » Lost to Indians (61-56), 3-2 | Comiskey Park I (27-28) | 48-63 | |
| » W: Luis Tiant (18-7) L: Wilbur Wood (8-6) | Ninth | 22½ out |
| Sunday, August 11 |
| » Lost to Indians (62-56), 6-1 | Comiskey Park I (27-29) | 48-64 | Lost 2 |
| » W: Stan Williams (9-7) L: Bob Priddy (3-7) | Ninth | 24½ out |
| » Lost to Indians (63-56), 2-1 | Comiskey Park I (27-30) | 48-65 | Lost 3 |
| » W: Eddie Fisher (3-2) L: Danny Lazar (0-1) | Ninth | 24½ out |
| Monday, August 12 |
| » Lost to Red Sox (63-54), 2-1 | Fenway Park (1-4) | 48-66 | Lost 4 |
| » W: Ray Culp (9-4) L: Wilbur Wood (8-7) S: Bill Landis (2) | Ninth | 25½ out |
| Tuesday, August 13 |
| » Lost to Red Sox (64-54), 4-3 | Fenway Park (1-5) | 48-67 | Lost 5 |
| » W: Juan Pizarro (5-4) L: Wilbur Wood (8-8) | Ninth | 25½ out |
| Wednesday, August 14 |
| » Defeated Red Sox (64-55), 5-3 | Fenway Park (2-5) | 49-67 | |
| » W: Tommy John (9-5) L: Dave Morehead (0-2) S: Bob Locker (8) | Ninth | 26 out |
| » Lost to Red Sox (65-55), 7-5 | Fenway Park (2-6) | 49-68 | |
| » W: Jerry Stephenson (2-7) L: Bob Priddy (3-8) S: Sparky Lyle (10) | Ninth | 26 out |
| Thursday, August 15 |
| » Lost to Red Sox (66-55), 3-0 | Fenway Park (2-7) | 49-69 | Lost 2 |
| » W: Gary Bell (10-8) L: Cisco Carlos (4-11) | Ninth | 26½ out |
| Friday, August 16 |
| » Lost to Indians (65-58), 4-3 | Cleveland Stadium (0-6) | 49-70 | Lost 3 |
| » W: Eddie Fisher (4-2) L: Hoyt Wilhelm (2-4) | Ninth | 27½ out |
| Saturday, August 17 |
| » Lost to Indians (66-58), 6-5 | Cleveland Stadium (0-7) | 49-71 | Lost 4 |
| » W: Stan Williams (10-7) L: Bob Priddy (3-9) S: Horacio Pina (1) | Ninth | 28½ out |
| Sunday, August 18 |
| » Defeated Indians (66-59), 4-2 | Cleveland Stadium (1-7) | 50-71 | |
| » W: Tommy John (10-5) L: Sonny Siebert (12-10) | Ninth | 27 out |
| » Defeated Indians (66-60), 8-1 | Cleveland Stadium (2-7) | 51-71 | Won 2 |
| » W: Joe Horlen (9-11) L: Steve Hargan (7-13) | Ninth | 27 out |
| Tuesday, August 20 |
| » Lost to Tigers (79-44), 7-0 | Tiger Stadium (1-5) | 51-72 | |
| » W: John Hiller (6-3) L: Jack Fisher (6-8) | Ninth | 27 out |
| » Defeated Tigers (79-45), 10-2 | Tiger Stadium (2-5) | 52-72 | |
| » W: Gary Peters (4-10) L: Denny McLain (25-4) | Ninth | 27 out |
| Wednesday, August 21 |
| » Lost to Tigers (80-45), 3-2 | Tiger Stadium (2-6) | 52-73 | |
| » W: Daryl Patterson (2-2) L: Wilbur Wood (8-9) | Ninth | 28 out |
| Thursday, August 22 |
| » Lost to Tigers (81-45), 4-2 | Tiger Stadium (2-7) | 52-74 | Lost 2 |
| » W: Mickey Lolich (12-7) L: Dennis Ribant (2-3) S: Don McMahon (1) | Ninth | 29 out |
| Friday, August 23 |
| » Defeated Twins (59-67), 4-2 | Comiskey Park I (28-30) | 53-74 | |
| » Manager: Al Lopez |
| » W: Wilbur Wood (9-9) L: Dean Chance (12-12) | Ninth | 28 out |
| Former White Sox Dutch Henry dies in Cleveland, OH at the age of 67. |
| Saturday, August 24 |
| » Defeated Twins (59-68), 4-2 | Comiskey Park I (29-30) | 54-74 | Won 2 |
| » W: Jack Fisher (7-8) L: Tom Hall (1-1) S: Hoyt Wilhelm (10) | Ninth | 27½ out |
| » Lost to Twins (60-68), 9-1 | Comiskey Park I (29-31) | 54-75 | |
| » W: Dave Boswell (9-10) L: Bob Priddy (3-10) | Ninth | 27½ out |
| » Major-league debuts: Jerry Nyman (White Sox) |
| Sunday, August 25 |
| » Lost to Twins (61-68), 10-2 | Comiskey Park I (29-32) | 54-76 | Lost 2 |
| » W: Jim Kaat (10-10) L: Gary Peters (4-11) | Ninth | 27 out |
| Monday, August 26 |
| » Lost to Tigers (82-49), 3-0 | County Stadium (1-8) | 54-77 | Lost 3 |
| » W: Earl Wilson (11-11) L: Cisco Carlos (4-12) | Ninth | 28 out |
| Tuesday, August 27 |
| » Defeated Tigers (82-50), 2-1 | Comiskey Park I (30-32) | 55-77 | |
| » W: Wilbur Wood (10-9) L: John Hiller (6-4) | Ninth | 27 out |
| Wednesday, August 28 |
| » Defeated Yankees (65-66), 3-0 | Comiskey Park I (31-32) | 56-77 | Won 2 |
| » W: Jerry Nyman (1-0) L: Mel Stottlemyre (17-11) | Ninth | 27 out |
| Thursday, August 29 |
| » Defeated Yankees (65-67), 1-0 | Comiskey Park I (32-32) | 57-77 | Won 3 |
| » W: Joe Horlen (10-11) L: Steve Barber (6-5) S: Wilbur Wood (15) | Ninth | 27 out |
| Friday, August 30 |
| » Lost to Twins (65-71), 5-4 | Metropolitan Stadium (3-4) | 57-78 | |
| » W: Al Worthington (3-5) L: Dennis Ribant (2-4) | Ninth | 28 out |
| Saturday, August 31 |
| » Lost to Twins (66-71), 4-3 | Metropolitan Stadium (3-5) | 57-79 | Lost 2 |
| » W: Dean Chance (13-13) L: Jack Fisher (7-9) S: Al Worthington (16) | Ninth | 28 out |
| Sunday, September 1 |
| » Defeated Twins (66-72), 5-4 | Metropolitan Stadium (4-5) | 58-79 | |
| » W: Wilbur Wood (11-9) L: Dave Boswell (9-12) | Ninth | 28 out |
| Monday, September 2 |
| » Lost to Senators (54-82), 1-0 | Robert F. Kennedy Stadium (2-3) | 58-80 | |
| » W: Jim Hannan (9-3) L: Joe Horlen (10-12) | Ninth | 29 out |
| » Lost to Senators (55-82), 11-3 | Robert F. Kennedy Stadium (2-4) | 58-81 | Lost 2 |
| » W: Barry Moore (2-5) L: Bob Priddy (3-11) S: Dick Bosman (1) | Ninth | 29 out |
| Tuesday, September 3 |
| » Lost to Senators (56-82), 2-1 | Robert F. Kennedy Stadium (2-5) | 58-82 | Lost 3 |
| » W: Joe Coleman (11-14) L: Cisco Carlos (4-13) | Ninth | 30 out |
| Wednesday, September 4 |
| » Defeated Senators (56-83), 3-0 | Robert F. Kennedy Stadium (3-5) | 59-82 | |
| » W: Bob Locker (5-4) L: Dick Bosman (2-9) S: Dennis Ribant (2) | Ninth | 30 out |
| Thursday, September 5 |
| » Defeated Senators (56-84), 2-1 | Robert F. Kennedy Stadium (4-5) | 60-82 | Won 2 |
| » W: Jerry Nyman (2-0) L: Camilo Pascual (12-10) S: Gary Peters (1) | Ninth | 29½ out |
| Friday, September 6 |
| » Defeated Orioles (81-61), 3-2 | Memorial Stadium (3-4) | 61-82 | Won 3 |
| » W: Hoyt Wilhelm (3-4) L: Pete Richert (6-3) S: Bob Locker (9) | Ninth | 29½ out |
| » Major-league debuts: Carlos May (White Sox) |
| Saturday, September 7 |
| » Lost to Orioles (82-61), 4-0 | Memorial Stadium (3-5) | 61-83 | |
| » W: Tom Phoebus (14-14) L: Cisco Carlos (4-14) | Ninth | 29½ out |
| Sunday, September 8 |
| » Lost to Orioles (83-61), 3-2 | Memorial Stadium (3-6) | 61-84 | Lost 2 |
| » W: Dave McNally (20-8) L: Jack Fisher (7-10) | Ninth | 29½ out |
| Tuesday, September 10 |
| » Lost to Yankees (74-70), 2-1 | Yankee Stadium (2-5) | 61-85 | Lost 3 |
| » W: Lindy McDaniel (3-1) L: Wilbur Wood (11-10) | Ninth | 31½ out |
| » Lost to Yankees (75-70), 5-0 | Yankee Stadium (2-6) | 61-86 | Lost 4 |
| » W: Joe Verbanic (6-5) L: Gary Peters (4-12) | Ninth |