| Friday, February 2 |
| Future Twin Scott Erickson is born in Long Beach, CA. |
| Wednesday, February 28 |
| Future Twin Mike Milchin is born in Knoxville, TN. |
| Sunday, March 17 |
| Future Twin Dan Masteller is born in Toledo, OH. |
| Wednesday, March 27 |
| Future Twin Tom Quinlan is born in St. Paul, MN. |
| Wednesday, April 10 |
| » Defeated Senators (0-1), 2-0 | Robert F. Kennedy Stadium (1-0) | 1-0 | |
| » W: Dean Chance (1-0) L: Camilo Pascual (0-1) | First | -- |
| » Major-league debuts: Del Unser (Senators) |
| Thursday, April 11 |
| » Defeated Senators (0-2), 5-4 | Robert F. Kennedy Stadium (2-0) | 2-0 | Won 2 |
| » W: Jim Merritt (1-0) L: Dennis Higgins (0-1) | First | -- |
| Saturday, April 13 |
| » Defeated Yankees (1-1), 6-0 | Yankee Stadium (1-0) | 3-0 | Won 3 |
| » W: Jim Perry (1-0) L: Bill Monbouquette (0-1) | First | -- |
| Sunday, April 14 |
| » Defeated Yankees (1-2), 4-3 | Yankee Stadium (2-0) | 4-0 | Won 4 |
| » W: Dean Chance (2-0) L: Fred Talbot (0-1) S: Al Worthington (1) | First | -- |
| » Major-league debuts: Bobby Cox (Yankees) |
| Monday, April 15 |
| » Defeated Orioles (2-2), 6-3 | Memorial Stadium (1-0) | 5-0 | Won 5 |
| » W: Dave Boswell (1-0) L: Tom Phoebus (1-1) | First | -- |
| Wednesday, April 17 |
| » Defeated Senators (2-4), 13-1 | Metropolitan Stadium (1-0) | 6-0 | Won 6 |
| » W: Jim Merritt (2-0) L: Dick Bosman (0-1) | First | -- |
| » Major-league debuts: Jim Holt (Twins) |
| Thursday, April 18 |
| » Lost to Senators (3-4), 7-6 | Metropolitan Stadium (1-1) | 6-1 | |
| » W: Phil Ortega (1-1) L: Dean Chance (2-1) S: Dave Baldwin (1) | First | -- |
| Saturday, April 20 |
| » Lost to Yankees (4-4), 4-2 | Metropolitan Stadium (1-2) | 6-2 | Lost 2 |
| » W: Mel Stottlemyre (2-1) L: Jim Perry (1-1) | Second | 1 out |
| Sunday, April 21 |
| » Defeated Yankees (4-5), 5-2 | Metropolitan Stadium (2-2) | 7-2 | |
| » W: Dave Boswell (2-0) L: Fred Talbot (0-2) S: Al Worthington (2) | Second | 1½ out |
| Monday, April 22 |
| » Lost to Orioles (6-4), 2-1 | Metropolitan Stadium (2-3) | 7-3 | |
| » W: Dave McNally (2-0) L: Jim Merritt (2-1) S: John O'Donoghue (1) | Second | 2 out |
| Wednesday, April 24 |
| » Lost to Orioles (7-4), 7-3 | Metropolitan Stadium (2-4) | 7-4 | Lost 2 |
| » W: Jim Hardin (2-0) L: Dean Chance (2-2) S: Eddie Watt (4) | Second | 2 out |
| Future Twin Todd Jones is born in Marietta, GA. |
| Thursday, April 25 |
| » Defeated White Sox (0-10), 3-2 | Metropolitan Stadium (3-4) | 8-4 | |
| » W: Jim Perry (2-1) L: Gary Peters (0-3) S: Al Worthington (3) | Second | 1½ out |
| Friday, April 26 |
| » Lost to White Sox (1-10), 3-2 | Metropolitan Stadium (3-5) | 8-5 | |
| » W: Tommy John (1-0) L: Dave Boswell (2-1) S: Wilbur Wood (1) | Third | 1½ out |
| Saturday, April 27 |
| » Defeated White Sox (1-11), 4-1 | Metropolitan Stadium (4-5) | 9-5 | |
| » W: Jim Merritt (3-1) L: Joe Horlen (0-4) | Second | 1½ out |
| Sunday, April 28 |
| » Lost to White Sox (2-11), 3-2 | Metropolitan Stadium (4-6) | 9-6 | |
| » W: Bob Locker (1-1) L: Dean Chance (2-3) | Second | 2 out |
| Monday, April 29 |
| » Defeated Red Sox (8-7), 11-2 | Fenway Park (1-0) | 10-6 | |
| » W: Jim Perry (3-1) L: Gary Bell (0-1) | Second | 2 out |
| Tuesday, April 30 |
| » Defeated Red Sox (8-8), 7-6 | Fenway Park (2-0) | 11-6 | Won 2 |
| » W: Dave Boswell (3-1) L: Dick Ellsworth (2-1) S: Ron Perranoski (1) | Second | 1 out |
| Wednesday, May 1 |
| » Lost to Tigers (13-5), 3-2 | Tiger Stadium (0-1) | 11-7 | |
| » W: Denny McLain (3-0) L: Jim Merritt (3-2) | Third | 2 out |
| Thursday, May 2 |
| » Defeated Tigers (13-6), 3-2 | Tiger Stadium (1-1) | 12-7 | |
| » W: Dean Chance (3-3) L: Dennis Ribant (0-1) S: Al Worthington (4) | Third | 1 out |
| Friday, May 3 |
| » Lost to Indians (8-11), 4-0 | Cleveland Stadium (0-1) | 12-8 | |
| » W: Luis Tiant (3-2) L: Jim Perry (3-2) | Third | 1½ out |
| Saturday, May 4 |
| » Lost to Indians (9-11), 2-0 | Cleveland Stadium (0-2) | 12-9 | Lost 2 |
| » W: Steve Hargan (2-3) L: Dave Boswell (3-2) | Third | 2½ out |
| Sunday, May 5 |
| » Lost to Indians (10-11), 2-1 | Cleveland Stadium (0-3) | 12-10 | Lost 3 |
| » W: Sonny Siebert (3-2) L: Al Worthington (0-1) S: Stan Williams (1) | Third | 3½ out |
| Monday, May 6 |
| » Lost to Athletics (12-11), 2-1 | Oakland-Alameda County Stadium (0-1) | 12-11 | Lost 4 |
| » W: Jim Nash (1-2) L: Dean Chance (3-4) S: Tony Pierce (1) | Third | 4½ out |
| Tuesday, May 7 |
| » Defeated Athletics (12-12), 2-1 | Oakland-Alameda County Stadium (1-1) | 13-11 | |
| » W: Jim Perry (4-2) L: Blue Moon Odom (2-3) S: Al Worthington (5) | Third | 3½ out |
| Wednesday, May 8 |
| » Lost to Athletics (13-12), 4-0 | Oakland-Alameda County Stadium (1-2) | 13-12 | |
| » W: Catfish Hunter (3-2) L: Dave Boswell (3-3) | Third | 3½ out |
| Thursday, May 9 |
| » Defeated Angels (12-15), 4-3 | Anaheim Stadium (1-0) | 14-12 | |
| » W: Ron Perranoski (1-0) L: Jim Weaver (0-1) S: Al Worthington (6) | Third | 3 out |
| Friday, May 10 |
| » Lost to Angels (13-15), 3-0 | Anaheim Stadium (1-1) | 14-13 | |
| » W: George Brunet (3-3) L: Jim Kaat (0-1) | Third | 3 out |
| » Defeated Angels (13-16), 6-5 | Anaheim Stadium (2-1) | 15-13 | |
| » W: Ron Perranoski (2-0) L: Minnie Rojas (1-1) S: Al Worthington (7) | Third | 3 out |
| Saturday, May 11 |
| » Lost to Angels (14-16), 5-1 | Anaheim Stadium (2-2) | 15-14 | |
| » W: Sammy Ellis (2-4) L: Jim Perry (4-3) | Fourth | 4 out |
| Sunday, May 12 |
| » Defeated Angels (14-17), 4-2 | Anaheim Stadium (3-2) | 16-14 | |
| » W: Ron Perranoski (3-0) L: Minnie Rojas (1-2) S: Al Worthington (8) | Third | 3 out |
| Tuesday, May 14 |
| » Lost to Athletics (15-15), 13-8 | Metropolitan Stadium (4-7) | 16-15 | |
| » W: Catfish Hunter (4-2) L: Jim Merritt (3-3) S: Jack Aker (5) | Fourth | 4 out |
| Thursday, May 16 |
| » Defeated Athletics (15-16), 4-3 | Metropolitan Stadium (5-7) | 17-15 | |
| » W: Al Worthington (1-1) L: Chuck Dobson (2-3) | Third | 3 out |
| Sunday, May 19 |
| » Lost to Angels (16-18), 2-1 | Metropolitan Stadium (5-8) | 17-16 | |
| » W: Sammy Ellis (3-4) L: Dave Boswell (3-4) S: Minnie Rojas (3) | Third | 4 out |
| » Defeated Angels (16-19), 3-2 | Metropolitan Stadium (6-8) | 18-16 | |
| » W: Jim Kaat (1-1) L: Clyde Wright (2-1) S: Ron Perranoski (2) | Third | 4 out |
| Monday, May 20 |
| » Lost to Tigers (23-12), 4-3 | Metropolitan Stadium (6-9) | 18-17 | |
| » W: Denny McLain (6-1) L: Jim Merritt (3-4) | Fourth | 5 out |
| Tuesday, May 21 |
| » Defeated Tigers (23-13), 3-1 | Metropolitan Stadium (7-9) | 19-17 | |
| » W: Dean Chance (4-4) L: Joe Sparma (3-4) | Third | 4 out |
| Wednesday, May 22 |
| » Defeated Tigers (23-14), 4-3 | Metropolitan Stadium (8-9) | 20-17 | Won 2 |
| » W: Ron Perranoski (4-0) L: Fred Lasher (2-1) S: Al Worthington (9) | Third | 3 out |
| Friday, May 24 |
| » Lost to Red Sox (20-18), 9-7 | Metropolitan Stadium (8-10) | 20-18 | |
| » W: Lee Stange (2-0) L: Dave Boswell (3-5) | Third | 3½ out |
| Saturday, May 25 |
| » Defeated Red Sox (20-19), 1-0 | Metropolitan Stadium (9-10) | 21-18 | |
| » W: Jim Kaat (2-1) L: Jose Santiago (5-2) | Fourth | 3½ out |
| Sunday, May 26 |
| » Defeated Red Sox (20-20), 5-4 | Metropolitan Stadium (10-10) | 22-18 | Won 2 |
| » W: Al Worthington (2-1) L: Sparky Lyle (2-1) | Fourth | 2½ out |
| Monday, May 27 |
| » Lost to Indians (24-18), 3-1 | Metropolitan Stadium (10-11) | 22-19 | |
| » W: Stan Williams (3-2) L: Dean Chance (4-5) S: Mike Paul (1) | Fourth | 2½ out |
| » Major-league debuts: Mike Paul (Indians) |
| Tuesday, May 28 |
| » Defeated Indians (24-19), 3-1 | Metropolitan Stadium (11-11) | 23-19 | |
| » W: Jim Perry (5-3) L: Sonny Siebert (6-3) S: Al Worthington (10) | Fourth | 2½ out |
| Wednesday, May 29 |
| » Defeated Indians (24-20), 1-0 | Metropolitan Stadium (12-11) | 24-19 | Won 2 |
| » W: Dave Boswell (4-5) L: Steve Hargan (3-5) | Third | 2½ out |
| Thursday, May 30 |
| » Lost to Indians (25-20), 3-1 | Metropolitan Stadium (12-12) | 24-20 | |
| » W: Sam McDowell (6-3) L: Jim Kaat (2-2) | Fourth | 3½ out |
| Friday, May 31 |
| » Lost to White Sox (18-25), 2-1 | Comiskey Park I (0-1) | 24-21 | Lost 2 |
| » W: Don McMahon (1-0) L: Bob Miller (0-1) | Fourth | 4½ out |
| Saturday, June 1 |
| » Lost to White Sox (19-25), 1-0 | Comiskey Park I (0-2) | 24-22 | Lost 3 |
| » W: Wilbur Wood (2-2) L: Dean Chance (4-6) | Fourth | 5½ out |
| Sunday, June 2 |
| » Lost to White Sox (20-25), 3-2 | Comiskey Park I (0-3) | 24-23 | Lost 4 |
| » W: Jack Fisher (1-2) L: Jim Perry (5-4) S: Wilbur Wood (5) | Fourth | 6½ out |
| » Lost to White Sox (21-25), 4-3 | Comiskey Park I (0-4) | 24-24 | Lost 5 |
| » W: Wilbur Wood (3-2) L: Ron Perranoski (4-1) | Fourth | 6½ out |
| Monday, June 3 |
| » Defeated Yankees (22-27), 4-3 | Yankee Stadium (3-0) | 25-24 | |
| » W: Ron Perranoski (5-1) L: John Wyatt (1-4) | Fourth | 5½ out |
| Tuesday, June 4 |
| » Defeated Yankees (22-28), 3-0 | Yankee Stadium (4-0) | 26-24 | Won 2 |
| » W: Jim Merritt (4-4) L: Stan Bahnsen (5-2) | Fourth | 5 out |
| Wednesday, June 5 |
| » Lost to Yankees (23-28), 7-2 | Yankee Stadium (4-1) | 26-25 | |
| » W: Mel Stottlemyre (7-4) L: Dean Chance (4-7) | Fourth | 6 out |
| Thursday, June 6 |
| » Defeated Yankees (23-29), 2-0 | Yankee Stadium (5-1) | 27-25 | |
| » W: Dave Boswell (5-5) L: Fred Talbot (0-7) S: Al Worthington (11) | Fourth | 6 out |
| Friday, June 7 |
| » Defeated Senators (22-30), 5-3 | Robert F. Kennedy Stadium (3-0) | 28-25 | Won 2 |
| » W: Jim Kaat (3-2) L: Phil Ortega (4-5) S: Al Worthington (12) | Fourth | 6½ out |
| » Lost to Senators (23-30), 3-2 | Robert F. Kennedy Stadium (3-1) | 28-26 | |
| » W: Bob Humphreys (2-0) L: Ron Perranoski (5-2) | Fourth | 6½ out |
| Sunday, June 9 |
| » Lost to Senators (24-30), 7-4 | Robert F. Kennedy Stadium (3-2) | 28-27 | Lost 2 |
| » W: Joe Coleman (4-5) L: Jim Merritt (4-5) | Fourth | 7 out |
| » Major-league debuts: Tom Hall (Twins) |
| Tuesday, June 11 |
| » Lost to Tigers (36-20), 3-1 | Tiger Stadium (1-2) | 28-28 | Lost 3 |
| » W: Pat Dobson (2-0) L: Dean Chance (4-8) S: Daryl Patterson (2) | Fourth | 9 out |
| » Lost to Tigers (37-20), 3-2 | Tiger Stadium (1-3) | 28-29 | Lost 4 |
| » W: John Hiller (4-1) L: Al Worthington (2-2) | Fourth | 9 out |
| Wednesday, June 12 |
| » Lost to Tigers (38-20), 2-1 | Tiger Stadium (1-4) | 28-30 | Lost 5 |
| » W: Mickey Lolich (5-3) L: Jim Kaat (3-3) | Fourth | 10 out |
| Future Twin Scott Aldred is born in Flint, MI. |
| Thursday, June 13 |
| » Lost to Tigers (39-20), 3-1 | Tiger Stadium (1-5) | 28-31 | Lost 6 |
| » W: Denny McLain (10-2) L: Jim Merritt (4-6) | Fifth | 11 out |
| Friday, June 14 |
| » Defeated Orioles (32-25), 2-1 | Metropolitan Stadium (13-12) | 29-31 | |
| » W: Jim Roland (1-0) L: Tom Phoebus (5-6) S: Ron Perranoski (3) | Fifth | 11 out |
| Saturday, June 15 |
| » Defeated Orioles (32-26), 3-1 | Metropolitan Stadium (14-12) | 30-31 | Won 2 |
| » W: Dean Chance (5-8) L: Dave McNally (6-6) | Fourth | 10 out |
| Sunday, June 16 |
| » Defeated Senators (24-35), 4-2 | Metropolitan Stadium (15-12) | 31-31 | Won 3 |
| » W: Dave Boswell (6-5) L: Jim Hannan (1-1) | Fifth | 9½ out |
| Monday, June 17 |
| » Defeated Senators (24-36), 4-1 | Metropolitan Stadium (16-12) | 32-31 | Won 4 |
| » W: Jim Kaat (4-3) L: Barry Moore (1-4) | Fourth | 9 out |
| Tuesday, June 18 |
| » Defeated Senators (24-37), 9-8 | Metropolitan Stadium (17-12) | 33-31 | Won 5 |
| » W: Jim Perry (6-4) L: Dennis Higgins (2-3) | Fourth | 9 out |
| Wednesday, June 19 |
| » Defeated Senators (24-38), 4-0 | Metropolitan Stadium (18-12) | 34-31 | Won 6 |
| » W: Dean Chance (6-8) L: Joe Coleman (4-7) | Fourth | 8 out |
| Friday, June 21 |
| » Lost to Yankees (30-35), 11-6 | Metropolitan Stadium (18-13) | 34-32 | |
| » W: Mel Stottlemyre (9-4) L: Dave Boswell (6-6) S: Steve Hamilton (4) | Fourth | 8½ out |
| Saturday, June 22 |
| » Lost to Yankees (31-35), 5-2 | Metropolitan Stadium (18-14) | 34-33 | Lost 2 |
| » W: Stan Bahnsen (7-2) L: Jim Kaat (4-4) | Fourth | 8½ out |
| Sunday, June 23 |
| » Defeated Yankees (31-36), 6-3 | Metropolitan Stadium (19-14) | 35-33 | |
| » W: Jim Merritt (5-6) L: Fritz Peterson (4-3) | Third | 8 out |
| Monday, June 24 |
| » Defeated White Sox (30-38), 1-0 | County Stadium (1-0) | 36-33 | Won 2 |
| » W: Dean Chance (7-8) L: Bob Priddy (0-4) | Third | 8 out |
| Thursday, June 27 |
| » Defeated Orioles (36-33), 2-0 | Memorial Stadium (2-0) | 37-33 | Won 3 |
| » W: Dave Boswell (7-6) L: Jim Hardin (8-4) | Second | 8 out |
| Friday, June 28 |
| » Defeated Orioles (36-34), 5-2 | Memorial Stadium (3-0) | 38-33 | Won 4 |
| » W: Jim Kaat (5-4) L: Tom Phoebus (6-8) S: Al Worthington (13) | Second | 8 out |
| Saturday, June 29 |
| » Lost to Orioles (37-34), 5-1 | Memorial Stadium (3-1) | 38-34 | |
| » W: Pete Richert (2-2) L: Jim Merritt (5-7) | Third | 9 out |
| Sunday, June 30 |
| » Lost to Orioles (38-34), 6-4 | Memorial Stadium (3-2) | 38-35 | Lost 2 |
| » W: Eddie Watt (3-4) L: Al Worthington (2-3) S: Moe Drabowsky (4) | Fourth | 9 out |
| Monday, July 1 |
| » Lost to Indians (43-36), 4-1 | Cleveland Stadium (0-4) | 38-36 | Lost 3 |
| » W: Sam McDowell (8-7) L: Dave Boswell (7-7) S: Stan Williams (5) | Fourth | 10 out |
| Tuesday, July 2 |
| » Defeated Indians (43-37), 6-0 | Cleveland Stadium (1-4) | 39-36 | |
| » W: Jim Kaat (6-4) L: Steve Hargan (5-9) | Fourth | 10 out |
| Wednesday, July 3 |
| » Lost to Indians (44-37), 1-0 | Cleveland Stadium (1-5) | 39-37 | |
| » W: Luis Tiant (13-5) L: Jim Merritt (5-8) | Fourth | 11 out |
| Thursday, July 4 |
| » Lost to Indians (45-37), 6-3 | Cleveland Stadium (1-6) | 39-38 | Lost 2 |
| » W: Vicente Romo (1-0) L: Dean Chance (7-9) S: Stan Williams (6) | Fourth | 12 out |
| Friday, July 5 |
| » Lost to Red Sox (39-38), 4-2 | Fenway Park (2-1) | 39-39 | Lost 3 |
| » W: Dick Ellsworth (7-5) L: Jim Perry (6-5) S: Lee Stange (7) | Fifth | 13 out |
| Saturday, July 6 |
| » Lost to Red Sox (40-38), 4-2 | Fenway Park (2-2) | 39-40 | Lost 4 |
| » W: Gary Bell (7-3) L: Dave Boswell (7-8) S: Lee Stange (8) | Fifth | 13 out |
| Sunday, July 7 |
| » Lost to Red Sox (41-38), 4-3 | Fenway Park (2-3) | 39-41 | Lost 5 |
| » W: Ray Culp (5-4) L: Jim Kaat (6-5) S: Juan Pizarro (2) | Fifth | 15 out |
| » Lost to Red Sox (42-38), 6-3 | Fenway Park (2-4) | 39-42 | Lost 6 |
| » W: Gary Waslewski (3-7) L: Jim Merritt (5-9) S: Lee Stange (9) | Fifth | 15 out |
| Future Twin Chuck Knoblauch is born in Houston, TX. |
| Thursday, July 11 |
| » Defeated Tigers (55-29), 5-4 | Metropolitan Stadium (20-14) | 40-42 | |
| » W: Ron Perranoski (6-2) L: John Hiller (5-3) | Fifth | 14 out |
| » Major-league debuts: Rick Renick (Twins) |
| Friday, July 12 |
| » Lost to Tigers (56-29), 5-1 | Metropolitan Stadium (20-15) | 40-43 | |
| » W: Denny McLain (17-2) L: Jim Kaat (6-6) | Fifth | 15 out |
| Saturday, July 13 |
| » Defeated Tigers (56-30), 7-6 | Metropolitan Stadium (21-15) | 41-43 | |
| » W: Jim Roland (2-0) L: Dennis Ribant (2-2) | Fifth | 14 out |
| Sunday, July 14 |
| » Lost to Indians (49-41), 6-3 | Metropolitan Stadium (21-16) | 41-44 | |
| » W: Luis Tiant (15-5) L: Jim Merritt (5-10) S: Stan Williams (8) | Fifth | 14 out |
| Monday, July 15 |
| » Lost to Indians (50-41), 4-2 | Metropolitan Stadium (21-17) | 41-45 | Lost 2 |
| » W: Sonny Siebert (10-5) L: Jim Perry (6-6) S: Stan Williams (9) | Sixth | 14 out |
| Tuesday, July 16 |
| » Defeated Red Sox (45-41), 12-3 | Metropolitan Stadium (22-17) | 42-45 | |
| » W: Dean Chance (8-9) L: Gary Bell (8-4) | Fifth | 14 out |
| Wednesday, July 17 |
| » Lost to Red Sox (46-41), 6-5 | Metropolitan Stadium (22-18) | 42-46 | |
| » W: Sparky Lyle (5-1) L: Al Worthington (2-4) S: Lee Stange (11) | Sixth | 14 out |
| Thursday, July 18 |
| » Defeated Red Sox (46-42), 7-2 | Metropolitan Stadium (23-18) | 43-46 | |
| » W: Dave Boswell (8-8) L: Gary Bell (8-5) | Fifth | 14 out |
| Friday, July 19 |
| » Lost to Athletics (44-47), 4-2 | Metropolitan Stadium (23-19) | 43-47 | |
| » W: Blue Moon Odom (8-6) L: Jim Merritt (5-11) S: Diego Segui (1) | Sixth | 15 out |
| Saturday, July 20 |
| » Lost to Athletics (45-47), 2-1 | Metropolitan Stadium (23-20) | 43-48 | Lost 2 |
| » W: Diego Segui (2-2) L: Ron Perranoski (6-3) S: Jack Aker (8) | Seventh | 15 out |
| Sunday, July 21 |
| » Defeated Athletics (45-48), 7-5 | Metropolitan Stadium (24-20) | 44-48 | |
| » W: Jim Kaat (7-6) L: Chuck Dobson (7-10) S: Al Worthington (14) | Fifth | 13 out |
| » Defeated Athletics (45-49), 10-0 | Metropolitan Stadium (25-20) | 45-48 | Won 2 |
| » W: Jim Perry (7-6) L: Paul Lindblad (4-2) | Fifth | 13 out |
| Monday, July 22 |
| » Lost to Angels (46-48), 6-5 | Metropolitan Stadium (25-21) | 45-49 | |
| » W: Andy Messersmith (1-0) L: Jim Roland (2-1) S: Tom Burgmeier (4) | Seventh | 13½ out |
| Tuesday, July 23 |
| » Lost to Angels (47-48), 3-1 | Metropolitan Stadium (25-22) | 45-50 | Lost 2 |
| » W: George Brunet (11-9) L: Ron Keller (0-1) | Seventh | 14 out |
| » Defeated Angels (47-49), 3-1 | Metropolitan Stadium (26-22) | 46-50 | |
| » W: Jim Merritt (6-11) L: Tom Murphy (2-3) | Seventh | 14 out |
| Wednesday, July 24 |
| » Defeated Angels (47-50), 12-1 | Metropolitan Stadium (27-22) | 47-50 | Won 2 |
| » W: Dean Chance (9-9) L: Jim McGlothlin (6-9) | Sixth | 13 out |
| Friday, July 26 |
| » Defeated Athletics (48-50), 10-4 | Oakland-Alameda County Stadium (2-2) | 48-50 | Won 3 |
| » W: Jim Kaat (8-6) L: Chuck Dobson (7-11) S: Ron Perranoski (4) | Fifth | 13½ out |
| Saturday, July 27 |
| » Lost to Athletics (49-50), 8-7 | Oakland-Alameda County Stadium (2-3) | 48-51 | |
| » W: Lew Krausse (7-8) L: Ron Perranoski (6-4) | Sixth | 14½ out |
| Sunday, July 28 |
| » Lost to Athletics (50-50), 4-3 | Oakland-Alameda County Stadium (2-4) | 48-52 | Lost 2 |
| » W: Jim Nash (8-6) L: Jim Merritt (6-12) S: Paul Lindblad (2) | Sixth | 14½ out |
| Monday, July 29 |
| » Lost to Angels (48-53), 2-1 | Anaheim Stadium (3-3) | 48-53 | Lost 3 |
| » W: Sammy Ellis (8-6) L: Dean Chance (9-10) | Seventh | 14½ out |
| Wednesday, July 31 |
| » Lost to White Sox (45-55), 12-8 | Metropolitan Stadium (27-23) | 48-54 | Lost 4 |
| » W: Wilbur Wood (8-5) L: Al Worthington (2-5) S: Hoyt Wilhelm (8) | Seventh | 16 out |
| Thursday, August 1 |
| » Defeated White Sox (45-56), 4-1 | Metropolitan Stadium (28-23) | 49-54 | |
| » W: Jim Perry (8-6) L: Jack Fisher (5-7) S: Dean Chance (1) | Seventh | 15 out |
| Friday, August 2 |
| » Lost to Tigers (66-40), 6-5 | Metropolitan Stadium (28-24) | 49-55 | |
| » W: Don McMahon (3-1) L: Bob Miller (0-2) S: Daryl Patterson (5) | Seventh | 16 out |
| Saturday, August 3 |
| » Defeated Tigers (66-41), 4-0 | Metropolitan Stadium (29-24) | 50-55 | |
| » W: Dean Chance (10-10) L: Earl Wilson (9-9) | Seventh | 15 out |
| Sunday, August 4 |
| » Lost to Tigers (67-41), 2-1 | Metropolitan Stadium (29-25) | 50-56 | |
| » W: Denny McLain (22-3) L: Jim Kaat (8-7) | Seventh | 16 out |
| Tuesday, August 6 |
| » Defeated Orioles (61-47), 5-4 | Memorial Stadium (4-2) | 51-56 | |
| » W: Jim Merritt (7-12) L: Gene Brabender (4-3) S: Ron Perranoski (5) | Sixth | 16 out |
| Wednesday, August 7 |
| » Lost to Orioles (62-47), 3-0 | Memorial Stadium (4-3) | 51-57 | |
| » W: Jim Hardin (14-7) L: Dave Boswell (8-9) | Seventh | 18 out |
| » Lost to Orioles (63-47), 9-6 | Memorial Stadium (4-4) | 51-58 | Lost 2 |
| » W: Pete Richert (4-2) L: Ron Perranoski (6-5) S: Eddie Watt (8) | Seventh | 18 out |
| Thursday, August 8 |
| » Lost to Orioles (64-47), 10-3 | Memorial Stadium (4-5) | 51-59 | Lost 3 |
| » W: Tom Phoebus (13-10) L: Jim Kaat (8-8) S: Dave Leonhard (1) | Seventh | 19 out |
| Friday, August 9 |
| » Defeated Yankees (51-58), 4-3 | Yankee Stadium (6-1) | 52-59 | |
| » W: Jim Roland (3-1) L: Fritz Peterson (6-8) | Seventh | 18 out |
| Saturday, August 10 |
| » Defeated Yankees (51-59), 3-2 | Yankee Stadium (7-1) | 53-59 | Won 2 |
| » W: Jim Merritt (8-12) L: Stan Bahnsen (10-8) | Sixth | 18 out |
| Sunday, August 11 |
| » Defeated Yankees (51-60), 11-2 | Yankee Stadium (8-1) | 54-59 | Won 3 |
| » W: Dean Chance (11-10) L: Mel Stottlemyre (15-9) | Sixth | 18½ out |
| Monday, August 12 |
| » Lost to Senators (43-71), 2-0 | Metropolitan Stadium (29-26) | 54-60 | |
| » W: Camilo Pascual (11-6) L: Jim Kaat (8-9) | Sixth | 19½ out |
| Tuesday, August 13 |
| » Defeated Senators (43-72), 8-4 | Metropolitan Stadium (30-26) | 55-60 | |
| » W: Tom Hall (1-0) L: Jim Hannan (7-3) S: Al Worthington (15) | Sixth | 18½ out |
| Wednesday, August 14 |
| » Lost to Senators (44-72), 4-2 | Metropolitan Stadium (30-27) | 55-61 | |
| » W: Dennis Higgins (3-4) L: Jim Merritt (8-13) | Seventh | 19½ out |
| Thursday, August 15 |
| » Lost to Orioles (69-49), 4-3 | Metropolitan Stadium (30-28) | 55-62 | Lost 2 |
| » W: Jim Hardin (15-8) L: Dean Chance (11-11) | Sixth | 19½ out |
| » Defeated Orioles (69-50), 2-1 | Metropolitan Stadium (31-28) | 56-62 | |
| » W: Ron Perranoski (7-5) L: Gene Brabender (5-4) | Sixth | 19½ out |
| Friday, August 16 |
| » Defeated Orioles (69-51), 5-2 | Metropolitan Stadium (32-28) | 57-62 | Won 2 |
| » W: Jim Kaat (9-9) L: Tom Phoebus (13-11) | Sixth | 19½ out |
| Saturday, August 17 |
| » Lost to Orioles (70-51), 8-2 | Metropolitan Stadium (32-29) | 57-63 | |
| » W: Dave McNally (16-8) L: Bob Miller (0-3) | Seventh | 20½ out |
| Sunday, August 18 |
| » Lost to Orioles (71-51), 7-1 | Metropolitan Stadium (32-30) | 57-64 | Lost 2 |
| » W: Dave Leonhard (6-5) L: Jim Merritt (8-14) | Seventh | 20½ out |
| Monday, August 19 |
| » Defeated Yankees (57-62), 1-0 | Metropolitan Stadium (33-30) | 58-64 | |
| » W: Dean Chance (12-11) L: Stan Bahnsen (11-9) | Seventh | 20 out |
| Tuesday, August 20 |
| » Lost to Yankees (58-62), 5-0 | Metropolitan Stadium (33-31) | 58-65 | |
| » W: Mel Stottlemyre (16-10) L: Dave Boswell (8-10) | Seventh | 20½ out |
| Wednesday, August 21 |
| » Lost to Yankees (59-62), 2-1 | Metropolitan Stadium (33-32) | 58-66 | Lost 2 |
| » W: Al Downing (2-1) L: Jim Kaat (9-10) S: Lindy McDaniel (7) | Seventh | 21½ out |
| Thursday, August 22 |
| » Defeated Yankees (59-63), 3-1 | Metropolitan Stadium (34-32) | 59-66 | |
| » W: Jim Merritt (9-14) L: Fritz Peterson (6-9) | Seventh | 21½ out |
| Friday, August 23 |
| » Lost to White Sox (53-74), 4-2 | Comiskey Park I (0-5) | 59-67 | |
| » W: Wilbur Wood (9-9) L: Dean Chance (12-12) | Seventh | 21½ out |
| Saturday, August 24 |
| » Lost to White Sox (54-74), 4-2 | Comiskey Park I (0-6) | 59-68 | Lost 2 |
| » W: Jack Fisher (7-8) L: Tom Hall (1-1) S: Hoyt Wilhelm (10) | Seventh | 21 out |
| » Defeated White Sox (54-75), 9-1 | Comiskey Park I (1-6) | 60-68 | |
| » W: Dave Boswell (9-10) L: Bob Priddy (3-10) | Seventh | 21 out |
| » Major-league debuts: Jerry Nyman (White Sox) |
| Sunday, August 25 |
| » Defeated White Sox (54-76), 10-2 | Comiskey Park I (2-6) | 61-68 | Won 2 |
| » W: Jim Kaat (10-10) L: Gary Peters (4-11) | Seventh | 19½ out |
| Monday, August 26 |
| » Defeated Senators (48-79), 4-2 | Robert F. Kennedy Stadium (4-2) | 62-68 | Won 3 |
| » W: Jim Merritt (10-14) L: Joe Coleman (9-14) S: Bob Miller (1) | Seventh | 20 out |
| » Lost to Senators (49-79), 1-0 | Robert F. Kennedy Stadium (4-3) | 62-69 | |
| » W: Dennis Higgins (4-4) L: Ron Perranoski (7-6) | Seventh | 20 out |
| Tuesday, August 27 |
| » Lost to Senators (50-79), 2-0 | Robert F. Kennedy Stadium (4-4) | 62-70 | Lost 2 |
| » W: Camilo Pascual (12-8) L: Dean Chance (12-13) | Seventh | 19½ out |
| » Defeated Senators (50-80), 7-1 | Robert F. Kennedy Stadium (5-4) | 63-70 | |
| » W: Jim Roland (4-1) L: Dick Bosman (1-8) | Seventh | 19½ out |
| Wednesday, August 28 |
| » Lost to Indians (72-64), 3-2 | Cleveland Stadium (1-7) | 63-71 | |
| » W: Vicente Romo (2-3) L: Dave Boswell (9-11) | Seventh | 20½ out |
| Thursday, August 29 |
| » Defeated Indians (72-65), 3-2 | Cleveland Stadium (2-7) | 64-71 | |
| » W: Jim Kaat (11-10) L: Mike Paul (1-7) | Seventh | 20½ out |
| Friday, August 30 |
| » Defeated White Sox (57-78), 5-4 | Metropolitan Stadium (35-32) | 65-71 | Won 2 |
| » W: Al Worthington (3-5) L: Dennis Ribant (2-4) | Seventh | 20½ out |
| Saturday, August 31 |
| » Defeated White Sox (57-79), 4-3 | Metropolitan Stadium (36-32) | 66-71 | Won 3 |
| » W: Dean Chance (13-13) L: Jack Fisher (7-9) S: Al Worthington (16) | Seventh | 19½ out |
| Sunday, September 1 |
| » Lost to White Sox (58-79), 5-4 | Metropolitan Stadium (36-33) | 66-72 | |
| » W: Wilbur Wood (11-9) L: Dave Boswell (9-12) | Seventh | 20½ out |
| Monday, September 2 |
| » Defeated Red Sox (74-65), 5-1 | Metropolitan Stadium (37-33) | 67-72 | |
| » W: Jim Kaat (12-10) L: Juan Pizarro (7-6) | Seventh | 20 out |
| Tuesday, September 3 |
| » Lost to Red Sox (75-65), 4-1 | Metropolitan Stadium (37-34) | 67-73 | |
| » W: Dick Ellsworth (13-6) L: Jim Merritt (10-15) | Seventh | 21 out |
| Wednesday, September 4 |
| » Lost to Red Sox (76-65), 10-2 | Metropolitan Stadium (37-35) | 67-74 | Lost 2 |
| » W: Gary Bell (11-10) L: Dean Chance (13-14) | Seventh | 22 out |
| Friday, September 6 |
| » Lost to Tigers (90-52), 8-3 | Tiger Stadium (1-6) | 67-75 | Lost 3 |
| » W: Denny McLain (28-5) L: Jim Kaat (12-11) | Seventh | 23 out |
| Future Twin Pat Meares is born in Salina, KS. |
| Saturday, September 7 |
| » Defeated Tigers (90-53), 2-1 | Tiger Stadium (2-6) | 68-75 | |
| » W: Al Worthington (4-5) L: Pat Dobson (5-6) | Seventh | 22 out |
| Sunday, September 8 |
| » Defeated Tigers (90-54), 3-1 | Tiger Stadium (3-6) | 69-75 | Won 2 |
| » W: Dean Chance (14-14) L: Earl Wilson (12-12) | Seventh | 21 out |
| Monday, September 9 |
| » Lost to Indians (77-71), 6-1 | Metropolitan Stadium (37-36) | 69-76 | |
| » W: Luis Tiant (20-9) L: Jim Merritt (10-16) | Seventh | 22 out |
| » Major-league debuts: Eddie Leon (Indians) |
| Tuesday, September 10 |
| » Lost to Indians (78-71), 6-2 | Metropolitan Stadium (37-37) | 69-77 | Lost 2 |
| » W: Stan Williams (12-10) L: Jim Kaat (12-12) | Seventh | 23 out |
| Wednesday, September 11 |
| » Lost to Indians (79-71), 1-0 | Metropolitan Stadium (37-38) | 69-78 | Lost 3 |
| » W: Vicente Romo (4-3) L: Ron Perranoski (7-7) S: Horacio Pina (2) | Seventh | 24 out |
| Friday, September 13 |
| » Lost to Red Sox (79-69), 3-0 | Fenway Park (2-5) | 69-79 | Lost 4 |
| » W: Ray Culp (13-5) L: Dean Chance (14-15) | Seventh | 25 out |
| » Major-league debuts: Luis Alvarado (Red Sox) |
| Future Twin Erik Bennett is born in Yreka, CA. Future Twin Denny Neagle is born in Gambrills, MD. |
| Saturday, September 14 |
| » Defeated Red Sox (79-70), 7-3 | Fenway Park (3-5) | 70-79 | |
| » W: Dave Boswell (10-12) L: Dick Ellsworth (13-7) | Sixth | 25 out |
| Sunday, September 15 |
| » Defeated Red Sox (79-71), 3-2 | Fenway Park (4-5) | 71-79 | Won 2 |
| » W: Jim Kaat (13-12) L: Dave Morehead (1-4) | Seventh | 25 out |
| Future Twin Rich Robertson is born in Nacogdoches, TX. |
| Monday, September 16 |
| » Defeated Angels (65-87), 4-3 | Metropolitan Stadium (38-38) | 72-79 | Won 3 |
| » W: Jim Merritt (11-16) L: Sammy Ellis (9-10) | Seventh | 25 out |
| Wednesday, September 18 |
| » Defeated Angels (65-88), 4-3 | Metropolitan Stadium (39-38) | 73-79 | Won 4 |
| » W: Dean Chance (15-15) L: Bill Harrelson (1-6) S: Ron Perranoski (6) | Seventh | 25½ out |
| » Lost to Angels (66-88), 4-3 | Metropolitan Stadium (39-39) | 73-80 | |
| » W: Clyde Wright (10-5) L: Danny Morris (0-1) S: Marty Pattin (3) | Seventh | 25½ out |
| Thursday, September 19 |
| Future Twin |
