| Friday, January 26 |
| Former Senator Eddie Phillips dies in Buffalo, NY at the age of 67. |
| Wednesday, April 10 |
| » Lost to Twins (1-0), 2-0 | Robert F. Kennedy Stadium (0-1) | 0-1 | |
| » W: Dean Chance (1-0) L: Camilo Pascual (0-1) | Second | 1 out |
| » Major-league debuts: Del Unser (Senators) |
| Thursday, April 11 |
| » Lost to Twins (2-0), 5-4 | Robert F. Kennedy Stadium (0-2) | 0-2 | Lost 2 |
| » W: Jim Merritt (1-0) L: Dennis Higgins (0-1) | Fifth | 2 out |
| Saturday, April 13 |
| » Lost to Athletics (1-1), 9-6 | Robert F. Kennedy Stadium (0-3) | 0-3 | Lost 3 |
| » W: Chuck Dobson (1-0) L: Phil Ortega (0-1) S: Jack Aker (1) | Seventh | 3 out |
| Sunday, April 14 |
| » Defeated Athletics (1-2), 8-1 | Robert F. Kennedy Stadium (1-3) | 1-3 | |
| » W: Dennis Higgins (1-1) L: Jim Nash (0-1) | Sixth | 3 out |
| Monday, April 15 |
| » Defeated Angels (2-3), 7-0 | Robert F. Kennedy Stadium (2-3) | 2-3 | Won 2 |
| » W: Camilo Pascual (1-1) L: Sammy Ellis (0-1) | Fourth | 3 out |
| Wednesday, April 17 |
| » Lost to Twins (6-0), 13-1 | Metropolitan Stadium (0-1) | 2-4 | |
| » W: Jim Merritt (2-0) L: Dick Bosman (0-1) | Fifth | 4 out |
| » Major-league debuts: Jim Holt (Twins) |
| Thursday, April 18 |
| » Defeated Twins (6-1), 7-6 | Metropolitan Stadium (1-1) | 3-4 | |
| » W: Phil Ortega (1-1) L: Dean Chance (2-1) S: Dave Baldwin (1) | Fourth | 3 out |
| Friday, April 19 |
| » Defeated Athletics (4-4), 3-0 | Oakland-Alameda County Stadium (1-0) | 4-4 | Won 2 |
| » W: Joe Coleman (1-0) L: Jim Nash (0-2) | Third | 2½ out |
| Saturday, April 20 |
| » Defeated Athletics (4-5), 4-1 | Oakland-Alameda County Stadium (2-0) | 5-4 | Won 3 |
| » W: Frank Bertaina (1-0) L: Blue Moon Odom (1-1) S: Dave Baldwin (2) | Fourth | 2½ out |
| Sunday, April 21 |
| » Defeated Athletics (4-6), 2-0 | Oakland-Alameda County Stadium (3-0) | 6-4 | Won 4 |
| » W: Camilo Pascual (2-1) L: Catfish Hunter (0-2) S: Darold Knowles (1) | Third | 3 out |
| Monday, April 22 |
| » Lost to Angels (4-7), 4-2 | Anaheim Stadium (0-1) | 6-5 | |
| » W: Jack Hamilton (1-0) L: Dick Bosman (0-2) | Fourth | 3½ out |
| Tuesday, April 23 |
| » Defeated Angels (4-8), 3-1 | Anaheim Stadium (1-1) | 7-5 | |
| » W: Phil Ortega (2-1) L: George Brunet (1-2) S: Darold Knowles (2) | Fourth | 3 out |
| Wednesday, April 24 |
| » Lost to Angels (5-8), 6-1 | Anaheim Stadium (1-2) | 7-6 | |
| » W: Clyde Wright (1-0) L: Joe Coleman (1-1) | Fourth | 3 out |
| Friday, April 26 |
| » Defeated Indians (5-7), 5-4 | Robert F. Kennedy Stadium (3-3) | 8-6 | |
| » W: Dennis Higgins (2-1) L: Tommy Gramly (0-1) | Fifth | 2 out |
| Saturday, April 27 |
| » Defeated Indians (5-8), 2-1 | Robert F. Kennedy Stadium (4-3) | 9-6 | Won 2 |
| » W: Camilo Pascual (3-1) L: Sam McDowell (1-1) S: Dave Baldwin (3) | Fourth | 2 out |
| Sunday, April 28 |
| » Defeated Indians (5-9), 1-0 | Robert F. Kennedy Stadium (5-3) | 10-6 | Won 3 |
| » W: Phil Ortega (3-1) L: Stan Williams (0-1) | Third | 2 out |
| » Lost to Indians (6-9), 2-0 | Robert F. Kennedy Stadium (5-4) | 10-7 | |
| » W: Luis Tiant (2-2) L: Barry Moore (0-1) | Third | 2 out |
| Tuesday, April 30 |
| » Defeated White Sox (2-12), 5-4 | Comiskey Park I (1-0) | 11-7 | |
| » W: Bob Humphreys (1-0) L: Bob Priddy (0-1) | Fourth | 1½ out |
| Wednesday, May 1 |
| » Lost to White Sox (3-12), 4-1 | Comiskey Park I (1-1) | 11-8 | |
| » W: Tommy John (2-0) L: Frank Bertaina (1-1) | Fourth | 2½ out |
| Friday, May 3 |
| » Lost to Orioles (13-6), 6-1 | Robert F. Kennedy Stadium (5-5) | 11-9 | Lost 2 |
| » W: Dave McNally (3-1) L: Camilo Pascual (3-2) | Fourth | 2½ out |
| Saturday, May 4 |
| » Lost to Orioles (14-6), 5-3 | Robert F. Kennedy Stadium (5-6) | 11-10 | Lost 3 |
| » W: Jim Hardin (4-0) L: Phil Ortega (3-2) | Fourth | 3½ out |
| Sunday, May 5 |
| » Lost to Orioles (15-6), 8-0 | Robert F. Kennedy Stadium (5-7) | 11-11 | Lost 4 |
| » W: Gene Brabender (2-1) L: Barry Moore (0-2) | Fourth | 4½ out |
| Tuesday, May 7 |
| » Lost to Red Sox (10-12), 3-2 | Robert F. Kennedy Stadium (5-8) | 11-12 | Lost 5 |
| » W: Jose Santiago (4-0) L: Joe Coleman (1-2) S: Lee Stange (2) | Sixth | 5 out |
| Wednesday, May 8 |
| » Lost to Red Sox (11-12), 3-1 | Robert F. Kennedy Stadium (5-9) | 11-13 | Lost 6 |
| » W: Dick Ellsworth (3-2) L: Dick Bosman (0-3) S: Gary Bell (1) | Seventh | 5 out |
| Thursday, May 9 |
| » Defeated Red Sox (11-13), 3-1 | Robert F. Kennedy Stadium (6-9) | 12-13 | |
| » W: Phil Ortega (4-2) L: Jerry Stephenson (1-4) S: Dave Baldwin (4) | Sixth | 4½ out |
| Friday, May 10 |
| » Lost to Tigers (17-9), 12-1 | Robert F. Kennedy Stadium (6-10) | 12-14 | |
| » W: Denny McLain (5-0) L: Barry Moore (0-3) | Sixth | 5 out |
| Saturday, May 11 |
| » Lost to Tigers (18-9), 12-2 | Robert F. Kennedy Stadium (6-11) | 12-15 | Lost 2 |
| » W: Joe Sparma (2-3) L: Frank Bertaina (1-2) | Seventh | 6 out |
| Sunday, May 12 |
| » Defeated Tigers (18-10), 6-3 | Robert F. Kennedy Stadium (7-11) | 13-15 | |
| » W: Joe Coleman (2-2) L: Daryl Patterson (1-1) | Fifth | 5 out |
| Tuesday, May 14 |
| » Lost to Red Sox (14-15), 5-4 | Fenway Park (0-1) | 13-16 | |
| » W: Sparky Lyle (1-0) L: Dennis Higgins (2-2) | Seventh | 6 out |
| Wednesday, May 15 |
| » Lost to Red Sox (15-15), 6-4 | Fenway Park (0-2) | 13-17 | Lost 2 |
| » W: Jose Santiago (5-1) L: Dick Bosman (0-4) S: Sparky Lyle (1) | Seventh | 6 out |
| Thursday, May 16 |
| » Defeated Indians (17-13), 4-1 | Cleveland Stadium (1-0) | 14-17 | |
| » W: Barry Moore (1-3) L: Sam McDowell (4-2) S: Dennis Higgins (1) | Seventh | 5½ out |
| Friday, May 17 |
| » Lost to Tigers (20-11), 7-3 | Tiger Stadium (0-1) | 14-18 | |
| » W: Joe Sparma (3-3) L: Steve Jones (0-1) | Seventh | 6½ out |
| Saturday, May 18 |
| » Defeated Tigers (20-12), 8-4 | Tiger Stadium (1-1) | 15-18 | |
| » W: Frank Bertaina (2-2) L: Mickey Lolich (2-2) | Fifth | 5½ out |
| Sunday, May 19 |
| » Lost to Tigers (21-12), 5-4 | Tiger Stadium (1-2) | 15-19 | |
| » W: Fred Lasher (2-0) L: Steve Jones (0-2) S: John Hiller (1) | Sixth | 7½ out |
| » Lost to Tigers (22-12), 7-0 | Tiger Stadium (1-3) | 15-20 | Lost 2 |
| » W: Les Cain (1-0) L: Camilo Pascual (3-3) S: Fred Lasher (3) | Sixth | 7½ out |
| Monday, May 20 |
| » Lost to Yankees (15-21), 6-1 | Robert F. Kennedy Stadium (7-12) | 15-21 | Lost 3 |
| » W: Jim Bouton (1-1) L: Dick Bosman (0-5) | Eighth | 8½ out |
| Tuesday, May 21 |
| » Lost to Yankees (16-21), 2-1 | Robert F. Kennedy Stadium (7-13) | 15-22 | Lost 4 |
| » W: Mel Stottlemyre (5-3) L: Joe Coleman (2-3) | Eighth | 8½ out |
| Wednesday, May 22 |
| » Defeated White Sox (16-19), 2-0 | Robert F. Kennedy Stadium (8-13) | 16-22 | |
| » W: Frank Bertaina (3-2) L: Gary Peters (2-4) S: Dave Baldwin (5) | Eighth | 7½ out |
| Friday, May 24 |
| » Lost to Orioles (21-17), 5-3 | Memorial Stadium (0-1) | 16-23 | |
| » W: Dave McNally (4-4) L: Phil Ortega (4-3) S: Pete Richert (1) | Eighth | 8½ out |
| » Lost to Orioles (22-17), 3-2 | Memorial Stadium (0-2) | 16-24 | Lost 2 |
| » W: Eddie Watt (2-3) L: Dave Baldwin (0-1) | Eighth | 8½ out |
| Saturday, May 25 |
| » Lost to Orioles (23-17), 5-2 | Memorial Stadium (0-3) | 16-25 | Lost 3 |
| » W: Jim Hardin (6-1) L: Joe Coleman (2-4) | Tenth | 9½ out |
| Sunday, May 26 |
| » Lost to Orioles (24-17), 8-7 | Memorial Stadium (0-4) | 16-26 | Lost 4 |
| » W: Gene Brabender (4-1) L: Frank Bertaina (3-3) S: Moe Drabowsky (2) | Ninth | 9½ out |
| Former Senator Doc Ayers dies in Pulaski, VA at the age of 79. |
| Thursday, May 30 |
| » Lost to Yankees (21-22), 13-4 | Yankee Stadium (0-1) | 16-27 | Lost 5 |
| » W: Stan Bahnsen (5-1) L: Joe Coleman (2-5) | Eighth | 10½ out |
| » Defeated Yankees (21-23), 6-2 | Yankee Stadium (1-1) | 17-27 | |
| » W: Camilo Pascual (4-3) L: Fred Talbot (0-6) S: Darold Knowles (3) | Eighth | 10½ out |
| Friday, May 31 |
| » Lost to Indians (26-20), 8-3 | Cleveland Stadium (1-1) | 17-28 | |
| » W: Luis Tiant (7-4) L: Phil Ortega (4-4) | Ninth | 11½ out |
| Saturday, June 1 |
| » Defeated Indians (26-21), 6-2 | Cleveland Stadium (2-1) | 18-28 | |
| » W: Darold Knowles (1-0) L: Stan Williams (3-3) | Tenth | 11½ out |
| Sunday, June 2 |
| » Lost to Indians (27-21), 10-5 | Cleveland Stadium (2-2) | 18-29 | |
| » W: Steve Hargan (4-5) L: Frank Bertaina (3-4) S: Billy Rohr (1) | Ninth | 11½ out |
| » Defeated Indians (27-22), 11-3 | Cleveland Stadium (3-2) | 19-29 | |
| » W: Jim Hannan (1-0) L: Sonny Siebert (6-4) | Ninth | 11½ out |
| Tuesday, June 4 |
| » Defeated Athletics (23-25), 4-2 | Robert F. Kennedy Stadium (9-13) | 20-29 | Won 2 |
| » W: Joe Coleman (3-5) L: Catfish Hunter (5-4) | Tenth | 10½ out |
| Wednesday, June 5 |
| » Defeated Athletics (23-26), 3-1 | Robert F. Kennedy Stadium (10-13) | 21-29 | Won 3 |
| » W: Camilo Pascual (5-3) L: Diego Segui (0-1) S: Darold Knowles (4) | Tenth | 10½ out |
| Thursday, June 6 |
| » Defeated Athletics (23-27), 4-3 | Robert F. Kennedy Stadium (11-13) | 22-29 | Won 4 |
| » W: Frank Bertaina (4-4) L: Chuck Dobson (2-6) S: Dennis Higgins (2) | Ninth | 10½ out |
| Friday, June 7 |
| » Lost to Twins (28-25), 5-3 | Robert F. Kennedy Stadium (11-14) | 22-30 | |
| » W: Jim Kaat (3-2) L: Phil Ortega (4-5) S: Al Worthington (12) | Ninth | 11 out |
| » Defeated Twins (28-26), 3-2 | Robert F. Kennedy Stadium (12-14) | 23-30 | |
| » W: Bob Humphreys (2-0) L: Ron Perranoski (5-2) | Ninth | 11 out |
| Sunday, June 9 |
| » Defeated Twins (28-27), 7-4 | Robert F. Kennedy Stadium (13-14) | 24-30 | Won 2 |
| » W: Joe Coleman (4-5) L: Jim Merritt (4-5) | Eighth | 10½ out |
| » Major-league debuts: Tom Hall (Twins) |
| Monday, June 10 |
| » Lost to Orioles (31-24), 4-1 | Robert F. Kennedy Stadium (13-15) | 24-31 | |
| » W: Jim Hardin (8-2) L: Camilo Pascual (5-4) | Ninth | 11 out |
| Tuesday, June 11 |
| » Lost to Orioles (32-24), 8-4 | Robert F. Kennedy Stadium (13-16) | 24-32 | Lost 2 |
| » W: Roger Nelson (1-0) L: Frank Bertaina (4-5) S: Moe Drabowsky (3) | Tenth | 12½ out |
| Thursday, June 13 |
| » Major-league debuts: Tom Murphy (Angels) |
| Friday, June 14 |
| » Lost to Angels (27-32), 2-0 | Anaheim Stadium (1-3) | 24-33 | Lost 3 |
| » W: George Brunet (6-6) L: Joe Coleman (4-6) | Ninth | 14½ out |
| Saturday, June 15 |
| » Lost to Angels (28-32), 5-4 | Anaheim Stadium (1-4) | 24-34 | Lost 4 |
| » W: Marty Pattin (1-2) L: Dave Baldwin (0-2) | Ninth | 14½ out |
| Sunday, June 16 |
| » Lost to Twins (31-31), 4-2 | Metropolitan Stadium (1-2) | 24-35 | Lost 5 |
| » W: Dave Boswell (6-5) L: Jim Hannan (1-1) | Tenth | 15 out |
| Monday, June 17 |
| » Lost to Twins (32-31), 4-1 | Metropolitan Stadium (1-3) | 24-36 | Lost 6 |
| » W: Jim Kaat (4-3) L: Barry Moore (1-4) | Ninth | 15½ out |
| Tuesday, June 18 |
| » Lost to Twins (33-31), 9-8 | Metropolitan Stadium (1-4) | 24-37 | Lost 7 |
| » W: Jim Perry (6-4) L: Dennis Higgins (2-3) | Tenth | 16½ out |
| Wednesday, June 19 |
| » Lost to Twins (34-31), 4-0 | Metropolitan Stadium (1-5) | 24-38 | Lost 8 |
| » W: Dean Chance (6-8) L: Joe Coleman (4-7) | Tenth | 16½ out |
| Friday, June 21 |
| » Defeated Athletics (32-33), 7-3 | Oakland-Alameda County Stadium (4-0) | 25-38 | |
| » W: Camilo Pascual (6-4) L: Chuck Dobson (4-7) | Tenth | 16 out |
| Saturday, June 22 |
| » Lost to Athletics (33-33), 4-1 | Oakland-Alameda County Stadium (4-1) | 25-39 | |
| » W: Lew Krausse (4-7) L: Barry Moore (1-5) | Tenth | 16 out |
| Sunday, June 23 |
| » Lost to Athletics (34-33), 9-0 | Oakland-Alameda County Stadium (4-2) | 25-40 | Lost 2 |
| » W: Jim Nash (6-5) L: Bruce Howard (0-3) | Tenth | 16½ out |
| Tuesday, June 25 |
| » Lost to Indians (39-34), 6-1 | Robert F. Kennedy Stadium (13-17) | 25-41 | Lost 3 |
| » W: Sonny Siebert (7-5) L: Joe Coleman (4-8) S: Stan Williams (4) | Tenth | 18 out |
| Wednesday, June 26 |
| » Defeated Indians (39-35), 8-2 | Robert F. Kennedy Stadium (14-17) | 26-41 | |
| » W: Camilo Pascual (7-4) L: Steve Hargan (5-8) | Tenth | 17½ out |
| Friday, June 28 |
| » Lost to Angels (35-36), 4-3 | Robert F. Kennedy Stadium (14-18) | 26-42 | |
| » W: Tom Murphy (2-0) L: Phil Ortega (4-6) S: Tom Burgmeier (1) | Tenth | 19 out |
| » Lost to Angels (36-36), 1-0 | Robert F. Kennedy Stadium (14-19) | 26-43 | Lost 2 |
| » W: Marty Pattin (2-2) L: Darold Knowles (1-1) | Tenth | 19 out |
| Saturday, June 29 |
| » Defeated Angels (36-37), 8-2 | Robert F. Kennedy Stadium (15-19) | 27-43 | |
| » W: Jim Hannan (2-1) L: Sammy Ellis (5-6) S: Dennis Higgins (3) | Tenth | 19 out |
| Sunday, June 30 |
| » Lost to Angels (37-37), 8-4 | Robert F. Kennedy Stadium (15-20) | 27-44 | |
| » W: Rickey Clark (1-8) L: Joe Coleman (4-9) S: Tom Burgmeier (2) | Tenth | 19 out |
| Monday, July 1 |
| » Defeated Yankees (33-40), 3-1 | Robert F. Kennedy Stadium (16-20) | 28-44 | |
| » W: Camilo Pascual (8-4) L: Bill Monbouquette (5-7) | Tenth | 19 out |
| Wednesday, July 3 |
| » Lost to Yankees (34-40), 4-1 | Robert F. Kennedy Stadium (16-21) | 28-45 | |
| » W: Mel Stottlemyre (10-5) L: Phil Ortega (4-7) | Tenth | 20½ out |
| Thursday, July 4 |
| » Defeated Yankees (34-41), 4-2 | Robert F. Kennedy Stadium (17-21) | 29-45 | |
| » W: Jim Hannan (3-1) L: Stan Bahnsen (7-4) S: Bob Humphreys (1) | Tenth | 20½ out |
| Friday, July 5 |
| » Lost to White Sox (33-43), 4-2 | Robert F. Kennedy Stadium (17-22) | 29-46 | |
| » W: Bob Priddy (1-4) L: Bruce Howard (0-4) S: Wilbur Wood (10) | Tenth | 21½ out |
| Saturday, July 6 |
| » Defeated White Sox (33-44), 8-4 | Robert F. Kennedy Stadium (18-22) | 30-46 | |
| » W: Joe Coleman (5-9) L: Jack Fisher (2-5) | Tenth | 20½ out |
| Sunday, July 7 |
| » Lost to White Sox (34-44), 4-3 | Robert F. Kennedy Stadium (18-23) | 30-47 | |
| » W: Don McMahon (2-1) L: Bob Humphreys (2-1) | Ninth | 22 out |
| Thursday, July 11 |
| » Lost to Orioles (44-37), 2-0 | Memorial Stadium (0-5) | 30-48 | Lost 2 |
| » W: Dave McNally (9-8) L: Joe Coleman (5-10) | Ninth | 22 out |
| Friday, July 12 |
| » Lost to Orioles (45-37), 3-2 | Memorial Stadium (0-6) | 30-49 | Lost 3 |
| » W: Jim Hardin (10-5) L: Camilo Pascual (8-5) S: Pete Richert (4) | Ninth | 23 out |
| Saturday, July 13 |
| » Lost to Orioles (46-37), 3-1 | Memorial Stadium (0-7) | 30-50 | Lost 4 |
| » W: Tom Phoebus (9-8) L: Jim Hannan (3-2) | Tenth | 23 out |
| Sunday, July 14 |
| » Lost to White Sox (35-47), 7-2 | Comiskey Park I (1-2) | 30-51 | Lost 5 |
| » W: Jack Fisher (3-5) L: Phil Ortega (4-8) | Ninth | 23½ out |
| » Lost to White Sox (36-47), 6-5 | Comiskey Park I (1-3) | 30-52 | Lost 6 |
| » W: Bob Locker (4-4) L: Bob Humphreys (2-2) | Ninth | 23½ out |
| Monday, July 15 |
| » Lost to White Sox (37-47), 3-2 | Comiskey Park I (1-4) | 30-53 | Lost 7 |
| » W: Cisco Carlos (4-8) L: Frank Bertaina (4-6) S: Hoyt Wilhelm (4) | Ninth | 23½ out |
| Tuesday, July 16 |
| » Lost to Yankees (40-45), 4-0 | Yankee Stadium (1-2) | 30-54 | Lost 8 |
| » W: Steve Barber (3-3) L: Joe Coleman (5-11) | Ninth | 25 out |
| » Lost to Yankees (41-45), 4-3 | Yankee Stadium (1-3) | 30-55 | Lost 9 |
| » W: Fred Talbot (1-8) L: Dick Bosman (0-6) | Ninth | 25 out |
| Wednesday, July 17 |
| » Defeated Yankees (41-46), 2-1 | Yankee Stadium (2-3) | 31-55 | |
| » W: Camilo Pascual (9-5) L: Mel Stottlemyre (12-6) S: Dennis Higgins (4) | Tenth | 24 out |
| Thursday, July 18 |
| » Lost to Yankees (42-46), 4-1 | Yankee Stadium (2-4) | 31-56 | |
| » W: Stan Bahnsen (8-6) L: Bob Humphreys (2-3) S: Lindy McDaniel (1) | Tenth | 25 out |
| Friday, July 19 |
| » Defeated Red Sox (46-43), 7-3 | Fenway Park (1-2) | 32-56 | |
| » W: Bruce Howard (1-4) L: Juan Pizarro (3-1) S: Dennis Higgins (5) | Ninth | 25 out |
| Saturday, July 20 |
| » Lost to Red Sox (47-43), 7-2 | Fenway Park (1-3) | 32-57 | |
| » W: Dick Ellsworth (8-5) L: Frank Bertaina (4-7) | Tenth | 25 out |
| Sunday, July 21 |
| » Lost to Red Sox (48-43), 4-3 | Fenway Park (1-4) | 32-58 | Lost 2 |
| » W: Gary Waslewski (4-7) L: Joe Coleman (5-12) S: Sparky Lyle (6) | Ninth | 24 out |
| » Defeated Red Sox (48-44), 4-3 | Fenway Park (2-4) | 33-58 | |
| » W: Dick Bosman (1-6) L: Gary Bell (8-6) S: Barry Moore (1) | Ninth | 24 out |
| Tuesday, July 23 |
| » Lost to Tigers (60-36), 6-4 | Robert F. Kennedy Stadium (18-24) | 33-59 | |
| » W: Denny McLain (19-3) L: Phil Ortega (4-9) S: Jon Warden (3) | Tenth | 25 out |
| Wednesday, July 24 |
| » Defeated Tigers (60-37), 6-3 | Robert F. Kennedy Stadium (19-24) | 34-59 | |
| » W: Jim Hannan (4-2) L: Mickey Lolich (7-6) S: Barry Moore (2) | Ninth | 24 out |
| Thursday, July 25 |
| » Lost to Tigers (61-37), 4-1 | Robert F. Kennedy Stadium (19-25) | 34-60 | |
| » W: Joe Sparma (8-9) L: Bruce Howard (1-5) | Ninth | 25 out |
| Friday, July 26 |
| » Lost to Red Sox (50-45), 2-1 | Robert F. Kennedy Stadium (19-26) | 34-61 | Lost 2 |
| » W: Dick Ellsworth (9-5) L: Frank Bertaina (4-8) | Ninth | 26 out |
| Saturday, July 27 |
| » Defeated Red Sox (50-46), 5-4 | Robert F. Kennedy Stadium (20-26) | 35-61 | |
| » W: Joe Coleman (6-12) L: Gary Bell (8-7) S: Dennis Higgins (6) | Tenth | 26 out |
| Former Senator Jack Redmond dies in Garland, TX at the age of 58. |
| Sunday, July 28 |
| » Lost to Red Sox (51-46), 10-8 | Robert F. Kennedy Stadium (20-27) | 35-62 | |
| » W: Gary Bell (9-7) L: Bob Humphreys (2-4) | Tenth | 26 out |
| Monday, July 29 |
| » Defeated Indians (57-47), 4-2 | Cleveland Stadium (4-2) | 36-62 | |
| » W: Jim Hannan (5-2) L: Vicente Romo (1-2) | Ninth | 25 out |
| Tuesday, July 30 |
| » Lost to Indians (58-47), 10-1 | Cleveland Stadium (4-3) | 36-63 | |
| » W: Sam McDowell (11-9) L: Bruce Howard (1-6) S: Mike Paul (3) | Ninth | 26 out |
| Wednesday, July 31 |
| » Lost to Tigers (65-39), 4-0 | Tiger Stadium (1-4) | 36-64 | Lost 2 |
| » W: Denny McLain (21-3) L: Frank Bertaina (4-9) | Tenth | 27 out |
| Thursday, August 1 |
| » Defeated Tigers (65-40), 9-3 | Tiger Stadium (2-4) | 37-64 | |
| » W: Joe Coleman (7-12) L: Pat Dobson (3-3) | Tenth | 26 out |
| Friday, August 2 |
| » Defeated White Sox (45-57), 11-6 | County Stadium (1-0) | 38-64 | Won 2 |
| » W: Camilo Pascual (10-5) L: Tommy John (7-4) | Tenth | 26 out |
| Saturday, August 3 |
| » Defeated White Sox (45-58), 3-1 | Comiskey Park I (2-4) | 39-64 | Won 3 |
| » W: Jim Hannan (6-2) L: Joe Horlen (8-10) S: Barry Moore (3) | Tenth | 25½ out |
| » Lost to White Sox (46-58), 6-2 | Comiskey Park I (2-5) | 39-65 | |
| » W: Bob Priddy (3-5) L: Phil Ortega (4-10) | Tenth | 25½ out |
| Sunday, August 4 |
| » Lost to White Sox (47-58), 7-2 | Comiskey Park I (2-6) | 39-66 | Lost 2 |
| » W: Jack Fisher (6-7) L: Dick Bosman (1-7) S: Wilbur Wood (14) | Tenth | 26½ out |
| Tuesday, August 6 |
| » Lost to Angels (51-59), 10-3 | Robert F. Kennedy Stadium (20-28) | 39-67 | Lost 3 |
| » W: Tom Murphy (4-4) L: Frank Bertaina (4-10) S: Dennis Bennett (1) | Tenth | 27 out |
| » Defeated Angels (51-60), 1-0 | Robert F. Kennedy Stadium (21-28) | 40-67 | |
| » W: Joe Coleman (8-12) L: Jim McGlothlin (6-10) | Tenth | 27 out |
| Wednesday, August 7 |
| » Lost to Angels (52-60), 4-2 | Robert F. Kennedy Stadium (21-29) | 40-68 | |
| » W: Sammy Ellis (9-7) L: Camilo Pascual (10-6) S: Andy Messersmith (1) | Tenth | 28½ out |
| Thursday, August 8 |
| » Defeated Angels (52-61), 7-2 | Robert F. Kennedy Stadium (22-29) | 41-68 | |
| » W: Jim Hannan (7-2) L: George Brunet (12-11) | Tenth | 28½ out |
| Friday, August 9 |
| » Lost to Athletics (58-54), 4-2 | Robert F. Kennedy Stadium (22-30) | 41-69 | |
| » W: Jack Aker (3-2) L: Dennis Higgins (2-4) | Tenth | 28 out |
| » Defeated Athletics (58-55), 3-2 | Robert F. Kennedy Stadium (23-30) | 42-69 | |
| » W: Phil Ortega (5-10) L: Paul Lindblad (4-3) | Tenth | 28 out |
| Saturday, August 10 |
| » Lost to Athletics (59-55), 4-1 | Robert F. Kennedy Stadium (23-31) | 42-70 | |
| » W: Blue Moon Odom (10-8) L: Frank Bertaina (4-11) S: Jack Aker (10) | Tenth | 29 out |
| Sunday, August 11 |
| » Lost to Athletics (60-55), 8-3 | Robert F. Kennedy Stadium (23-32) | 42-71 | Lost 2 |
| » W: Jim Nash (10-7) L: Joe Coleman (8-13) | Tenth | 30½ out |
| Monday, August 12 |
| » Defeated Twins (54-60), 2-0 | Metropolitan Stadium (2-5) | 43-71 | |
| » W: Camilo Pascual (11-6) L: Jim Kaat (8-9) | Tenth | 30½ out |
| Tuesday, August 13 |
| » Lost to Twins (55-60), 8-4 | Metropolitan Stadium (2-6) | 43-72 | |
| » W: Tom Hall (1-0) L: Jim Hannan (7-3) S: Al Worthington (15) | Tenth | 30½ out |
| Wednesday, August 14 |
| » Defeated Twins (55-61), 4-2 | Metropolitan Stadium (3-6) | 44-72 | |
| » W: Dennis Higgins (3-4) L: Jim Merritt (8-13) | Tenth | 30½ out |
| Thursday, August 15 |
| » Lost to Angels (54-66), 3-1 | Anaheim Stadium (1-5) | 44-73 | |
| » W: Jim McGlothlin (8-10) L: Frank Bertaina (4-12) | Tenth | 31 out |
| Friday, August 16 |
| » Defeated Angels (54-67), 4-2 | Anaheim Stadium (2-5) | 45-73 | |
| » W: Joe Coleman (9-13) L: Bill Harrelson (0-4) S: Dave Baldwin (6) | Tenth | 31 out |
| Saturday, August 17 |
| » Lost to Angels (55-67), 5-3 | Anaheim Stadium (2-6) | 45-74 | |
| » W: Andy Messersmith (2-0) L: Camilo Pascual (11-7) | Tenth | 32 out |
| Sunday, August 18 |
| » Lost to Angels (56-67), 6-4 | Anaheim Stadium (2-7) | 45-75 | Lost 2 |
| » W: Tom Murphy (5-6) L: Phil Ortega (5-11) S: Bobby Locke (2) | Tenth | 32 out |
| Monday, August 19 |
| » Defeated Athletics (62-61), 4-1 | Oakland-Alameda County Stadium (5-2) | 46-75 | |
| » W: Bob Humphreys (3-4) L: Blue Moon Odom (11-9) | Tenth | 31½ out |
| Tuesday, August 20 |
| » Defeated Athletics (62-62), 7-5 | Oakland-Alameda County Stadium (6-2) | 47-75 | Won 2 |
| » W: Frank Bertaina (5-12) L: Jim Nash (10-9) S: Dennis Higgins (7) | Tenth | 31½ out |
| » Lost to Athletics (63-62), 4-3 | Oakland-Alameda County Stadium (6-3) | 47-76 | |
| » W: Diego Segui (4-2) L: Bob Humphreys (3-5) | Tenth | 31½ out |
| Friday, August 23 |
| » Lost to Indians (70-61), 6-2 | Robert F. Kennedy Stadium (23-33) | 47-77 | Lost 2 |
| » W: Mike Paul (1-6) L: Camilo Pascual (11-8) S: Eddie Fisher (3) | Tenth | 32½ out |
| Saturday, August 24 |
| » Lost to Indians (71-61), 2-1 | Robert F. Kennedy Stadium (23-34) | 47-78 | Lost 3 |
| » W: Steve Hargan (8-13) L: Phil Ortega (5-12) | Tenth | 32½ out |
| Sunday, August 25 |
| » Defeated Indians (71-62), 10-9 | Robert F. Kennedy Stadium (24-34) | 48-78 | |
| » W: Bob Humphreys (4-5) L: Steve Hargan (8-14) S: Dennis Higgins (8) | Tenth | 31 out |
| Monday, August 26 |
| » Lost to Twins (62-68), 4-2 | Robert F. Kennedy Stadium (24-35) | 48-79 | |
| » W: Jim Merritt (10-14) L: Joe Coleman (9-14) S: Bob Miller (1) | Tenth | 31½ out |
| » Defeated Twins (62-69), 1-0 | Robert F. Kennedy Stadium (25-35) | 49-79 | |
| » W: Dennis Higgins (4-4) L: Ron Perranoski (7-6) | Tenth | 31½ out |
| Tuesday, August 27 |
| » Defeated Twins (62-70), 2-0 | Robert F. Kennedy Stadium (26-35) | 50-79 | Won 2 |
| » W: Camilo Pascual (12-8) L: Dean Chance (12-13) | Tenth | 31 out |
| » Lost to Twins (63-70), 7-1 | Robert F. Kennedy Stadium (26-36) | 50-80 | |
| » W: Jim Roland (4-1) L: Dick Bosman (1-8) | Tenth | 31 out |
| Wednesday, August 28 |
| » Defeated Orioles (78-55), 3-2 | Memorial Stadium (1-7) | 51-80 | |
| » W: Jim Hannan (8-3) L: Jim Hardin (17-9) S: Dennis Higgins (9) | Tenth | 31 out |
| Thursday, August 29 |
| » Defeated Orioles (78-56), 5-4 | Memorial Stadium (2-7) | 52-80 | Won 2 |
| » W: Dick Bosman (2-8) L: Eddie Watt (5-5) | Tenth | 31 out |
| Friday, August 30 |
| » Defeated Red Sox (72-64), 5-1 | Fenway Park (3-4) | 53-80 | Won 3 |
| » W: Joe Coleman (10-14) L: Gary Bell (10-10) | Tenth | 31 out |
| Saturday, August 31 |
| » Lost to Red Sox (73-64), 6-4 | Fenway Park (3-5) | 53-81 | |
| » W: Jim Lonborg (5-5) L: Frank Bertaina (5-13) S: Bill Landis (3) | Tenth | 31 out |
| Sunday, September 1 |
| » Lost to Red Sox (74-64), 7-4 | Fenway Park (3-6) | 53-82 | Lost 2 |
| » W: Ray Culp (11-5) L: Camilo Pascual (12-9) | Tenth | 32 out |
| Monday, September 2 |
| » Defeated White Sox (58-80), 1-0 | Robert F. Kennedy Stadium (27-36) | 54-82 | |
| » W: Jim Hannan (9-3) L: Joe Horlen (10-12) | Tenth | 31 out |
| » Defeated White Sox (58-81), 11-3 | Robert F. Kennedy Stadium (28-36) | 55-82 | Won 2 |
| » W: Barry Moore (2-5) L: Bob Priddy (3-11) S: Dick Bosman (1) | Tenth | 31 out |
| Tuesday, September 3 |
| » Defeated White Sox (58-82), 2-1 | Robert F. Kennedy Stadium (29-36) | 56-82 | Won 3 |
| » W: Joe Coleman (11-14) L: Cisco Carlos (4-13) | Tenth | 31 out |
| Wednesday, September 4 |
| » Lost to White Sox (59-82), 3-0 | Robert F. Kennedy Stadium (29-37) | 56-83 | |
| » W: Bob Locker (5-4) L: Dick Bosman (2-9) S: Dennis Ribant (2) | Tenth | 32 out |
| Thursday, September 5 |
| » Lost to White Sox (60-82), 2-1 | Robert F. Kennedy Stadium (29-38) | 56-84 | Lost 2 |
| » W: Jerry Nyman (2-0) L: Camilo Pascual (12-10) S: Gary Peters (1) | Tenth | 32½ out |
| Saturday, September 7 |
| » Lost to Yankees (71-70), 16-2 | Yankee Stadium (2-5) | 56-85 | Lost 3 |
| » W: Mel Stottlemyre (19-11) L: Jim Hannan (9-4) | Tenth | 33½ out |
| » Lost to Yankees (72-70), 10-0 | Yankee Stadium (2-6) | 56-86 | Lost 4 |
| » W: Fritz Peterson (10-9) L: Barry Moore (2-6) | Tenth | 33½ out |
| Sunday, September 8 |
| » Lost to Yankees (73-70), 7-2 | Yankee Stadium (2-7) | 56-87 | Lost 5 |
| » W: Stan Bahnsen (15-10) L: Joe Coleman (11-15) | Tenth | 33½ out |
| Monday, September 9 |
| » Defeated Orioles (83-62), 6-2 | Robert F. Kennedy Stadium (30-38) | 57-87 | |
| » W: Jim Hannan (10-4) L: Gene Brabender (6-6) S: Dennis Higgins (10) | Tenth | 33½ out |
| Wednesday, September 11 |
| » Lost to Orioles (84-62), 6-1 | Robert F. Kennedy Stadium (30-39) | 57-88 | |
| » W: Jim Hardin (18-10) L: Camilo Pascual (12-11) | Tenth | 35½ out |
| » Lost to Orioles (85-62), 4-1 | Robert F. Kennedy Stadium (30-40) | 57-89 | Lost 2 |
| » W: Moe Drabowsky (4-4) L: Bob Humphreys (4-6) S: Pete Richert (5) | Tenth | 35½ out |
| » Major-league debuts: Dick Billings (Senators) |
| Thursday, September 12 |
| » Defeated Orioles (85-63), 4-1 | Robert F. Kennedy Stadium (31-40) | 58-89 | |
| » W: Frank Bertaina (6-13) L: Dave McNally (20-9) S: Dennis Higgins (11) | Tenth | 35 out |
| Former Senator Don Rudolph dies in Granada Hills, CA at the age of 38. |
| Friday, September 13 |
| » Lost to Yankees (77-70), 4-2 | Robert F. Kennedy Stadium (31-41) | 58-90 | |
| » W: Mel Stottlemyre (20-11) L: Joe Coleman (11-16) | Tenth | 36½ out |
| » Lost to Yankees (78-70), 2-1 | Robert F. Kennedy Stadium (31-42) | 58-91 | Lost 2 |
| » W: Stan Bahnsen (16-10) L: Jim Hannan (10-5) | Tenth | 36½ out |
| Saturday, September 14 |
| » Lost to Yankees (79-70), 4-1 | Robert F. Kennedy Stadium (31-43) | 58-92 | Lost 3 |
| » W: Al Downing (3-2) L: Gerry Schoen (0-1) | Ninth | 37½ out |
| Sunday, September 15 |
| » Lost to Yankees (80-70), 3-2 | Robert F. Kennedy Stadium (31-44) | 58-93 | Lost 4 |
| » W: Fritz Peterson (12-9) L: Camilo Pascual (12-12) S: Lindy McDaniel (9) | Tenth | 38½ out |
| Tuesday, September 17 |
| » Defeated Indians (81-73), 4-2 | Cleveland Stadium (5-3) | 59-93 | |
| » W: Barry Moore (3-6) L: Sam McDowell (14-13) S: Bob Humphreys (2) | Ninth | 39 out |
| Friday, September 20 |
| » Lost to Tigers (100-54), 6-3 | Robert F. Kennedy Stadium (31-45) | 59-94 | |
| » W: Mickey Lolich (16-9) L: Bob Humphreys (4-7) S: Pat Dobson (7) | Tenth | 40½ out |
| Saturday, September 21 |
| » Lost to Tigers (101-54), 4-3 | Robert F. Kennedy Stadium (31-46) | 59-95 | Lost 2 |
| » W: Joe Sparma (10-10) L: Casey Cox (0-1) | Tenth | 41½ out |
| Sunday, September 22 |
| » Defeated Tigers (101-55), 6-0 | Robert F. Kennedy Stadium (32-46) | 60-95 | |
| » W: Camilo Pascual (13-12) L: John Hiller (9-6) | Tenth | 40½ out |
| Monday, September 23 |
| » Defeated Red Sox (84-73), 6-5 | Robert F. Kennedy Stadium (33-46) | 61-95 | Won 2 |
| » W: Steve Jones (1-2) L: Juan Pizarro (7-8) | Tenth | 39½ out |
| Tuesday, September 24 |
| » Defeated Red Sox (84-74), 10-2 | Robert F. Kennedy Stadium (34-46) |