| Monday, January 8 |
| Future Oriole Paul Carey is born in Boston, MA. |
| Sunday, January 21 |
| Future Oriole Keith Shepherd is born in Wabash, IN. |
| Thursday, February 1 |
| Future Oriole Kent Mercker is born in Indianapolis, IN. |
| Friday, February 2 |
| Future Oriole Scott Erickson is born in Long Beach, CA. |
| Monday, February 5 |
| Future Oriole Roberto Alomar is born in Ponce, P.R. |
| Thursday, February 15 |
| Future Oriole Luis Mercedes is born in San Pedro de Macoris, D.R. |
| Wednesday, February 28 |
| Future Oriole Mike Milchin is born in Knoxville, TN. |
| Sunday, March 3 |
| Future Oriole Bobby Munoz is born in Rio Piedras, P.R. |
| Friday, March 29 |
| Future Oriole Juan Bell is born in San Pedro de Macoris, D.R. |
| Thursday, April 4 |
| Future Oriole Jim Dedrick is born in Los Angeles, CA. |
| Wednesday, April 10 |
| » Defeated Athletics (0-1), 3-1 | Memorial Stadium (1-0) | 1-0 | |
| » W: Tom Phoebus (1-0) L: Catfish Hunter (0-1) S: Eddie Watt (1) | First | -- |
| Saturday, April 13 |
| » Defeated Angels (1-2), 3-0 | Memorial Stadium (2-0) | 2-0 | Won 2 |
| » W: Jim Hardin (1-0) L: Jim McGlothlin (0-1) S: Eddie Watt (2) | Second | ½ out |
| » Major-league debuts: Ellie Hendricks (Orioles) |
| Sunday, April 14 |
| » Lost to Angels (2-2), 6-2 | Memorial Stadium (2-1) | 2-1 | |
| » W: George Brunet (1-1) L: Bruce Howard (0-1) S: Clyde Wright (1) | Third | 1½ out |
| » Major-league debuts: Merv Rettenmund (Orioles) |
| Monday, April 15 |
| » Lost to Twins (5-0), 6-3 | Memorial Stadium (2-2) | 2-2 | Lost 2 |
| » W: Dave Boswell (1-0) L: Tom Phoebus (1-1) | Third | 2½ out |
| Wednesday, April 17 |
| » Defeated Athletics (3-3), 4-1 | Oakland-Alameda County Stadium (1-0) | 3-2 | |
| » W: Dave McNally (1-0) L: Lew Krausse (0-1) | Third | 2½ out |
| Thursday, April 18 |
| » Lost to Athletics (4-3), 4-3 | Oakland-Alameda County Stadium (1-1) | 3-3 | |
| » W: Paul Lindblad (1-0) L: Gene Brabender (0-1) | Third | 2½ out |
| Friday, April 19 |
| » Lost to Angels (3-5), 2-1 | Anaheim Stadium (0-1) | 3-4 | Lost 2 |
| » W: Minnie Rojas (1-0) L: Eddie Watt (0-1) | Fourth | 3 out |
| Saturday, April 20 |
| » Defeated Angels (3-6), 10-1 | Anaheim Stadium (1-1) | 4-4 | |
| » W: Tom Phoebus (2-1) L: Sammy Ellis (0-2) S: Roger Nelson (1) | Fifth | 3 out |
| » Major-league debuts: Chico Fernandez (Orioles) |
| Sunday, April 21 |
| » Defeated Angels (3-7), 11-4 | Anaheim Stadium (2-1) | 5-4 | Won 2 |
| » W: Moe Drabowsky (1-0) L: Tom Burgmeier (0-1) S: Eddie Watt (3) | Fourth | 3½ out |
| Monday, April 22 |
| » Defeated Twins (7-3), 2-1 | Metropolitan Stadium (1-0) | 6-4 | Won 3 |
| » W: Dave McNally (2-0) L: Jim Merritt (2-1) S: John O'Donoghue (1) | Third | 3 out |
| Wednesday, April 24 |
| » Defeated Twins (7-4), 7-3 | Metropolitan Stadium (2-0) | 7-4 | Won 4 |
| » W: Jim Hardin (2-0) L: Dean Chance (2-2) S: Eddie Watt (4) | Second | 2 out |
| Friday, April 26 |
| » Lost to Red Sox (7-4), 6-3 | Memorial Stadium (2-3) | 7-5 | |
| » W: Lee Stange (1-0) L: Pete Richert (0-1) | Fourth | 2 out |
| Saturday, April 27 |
| » Defeated Red Sox (7-5), 6-0 | Memorial Stadium (3-3) | 8-5 | |
| » W: Tom Phoebus (3-1) L: Gary Waslewski (2-1) | Third | 2 out |
| Sunday, April 28 |
| » Lost to Red Sox (8-5), 3-0 | Memorial Stadium (3-4) | 8-6 | |
| » W: Jose Santiago (2-0) L: Dave McNally (2-1) | Second | 2 out |
| » Defeated Red Sox (8-6), 6-1 | Memorial Stadium (4-4) | 9-6 | |
| » W: Jim Hardin (3-0) L: Jerry Stephenson (1-2) | Second | 2 out |
| Tuesday, April 30 |
| » Defeated Yankees (8-9), 6-5 | Memorial Stadium (5-4) | 10-6 | Won 2 |
| » W: Gene Brabender (1-1) L: Stan Bahnsen (1-1) S: Moe Drabowsky (1) | Third | 1½ out |
| Wednesday, May 1 |
| » Defeated Yankees (8-10), 6-1 | Memorial Stadium (6-4) | 11-6 | Won 3 |
| » W: Dave Leonhard (1-0) L: Mel Stottlemyre (3-2) | Second | 1½ out |
| Thursday, May 2 |
| » Defeated Yankees (8-11), 7-3 | Memorial Stadium (7-4) | 12-6 | Won 4 |
| » W: Tom Phoebus (4-1) L: Fritz Peterson (1-2) | Second | ½ out |
| Friday, May 3 |
| » Defeated Senators (11-9), 6-1 | Robert F. Kennedy Stadium (1-0) | 13-6 | Won 5 |
| » W: Dave McNally (3-1) L: Camilo Pascual (3-2) | First | -- |
| Saturday, May 4 |
| » Defeated Senators (11-10), 5-3 | Robert F. Kennedy Stadium (2-0) | 14-6 | Won 6 |
| » W: Jim Hardin (4-0) L: Phil Ortega (3-2) | First | -- |
| Sunday, May 5 |
| » Defeated Senators (11-11), 8-0 | Robert F. Kennedy Stadium (3-0) | 15-6 | Won 7 |
| » W: Gene Brabender (2-1) L: Barry Moore (0-2) | First | -- |
| Monday, May 6 |
| » Defeated Tigers (14-9), 4-0 | Memorial Stadium (8-4) | 16-6 | Won 8 |
| » W: Dave Leonhard (2-0) L: Joe Sparma (1-3) | First | -- |
| Tuesday, May 7 |
| » Lost to Tigers (15-9), 2-1 | Memorial Stadium (8-5) | 16-7 | |
| » W: Mickey Lolich (2-1) L: Tom Phoebus (4-2) S: Jon Warden (1) | First | -- |
| Wednesday, May 8 |
| » Lost to Tigers (16-9), 3-1 | Memorial Stadium (8-6) | 16-8 | Lost 2 |
| » W: Earl Wilson (3-4) L: Dave McNally (3-2) S: Jon Warden (2) | First | -- |
| Friday, May 10 |
| » Lost to Indians (13-12), 12-0 | Memorial Stadium (8-7) | 16-9 | Lost 3 |
| » W: Sonny Siebert (4-2) L: Jim Hardin (4-1) | Second | ½ out |
| Saturday, May 11 |
| » Lost to Indians (14-12), 4-3 | Memorial Stadium (8-8) | 16-10 | Lost 4 |
| » W: Sam McDowell (4-1) L: Eddie Watt (0-2) | Second | 1½ out |
| Sunday, May 12 |
| » Lost to Indians (15-12), 2-0 | Memorial Stadium (8-9) | 16-11 | Lost 5 |
| » W: Luis Tiant (5-2) L: Tom Phoebus (4-3) | Second | 2 out |
| » Lost to Indians (16-12), 4-1 | Memorial Stadium (8-10) | 16-12 | Lost 6 |
| » W: Stan Williams (1-1) L: Dave Leonhard (2-1) | Second | 2 out |
| Tuesday, May 14 |
| » Lost to Tigers (19-10), 4-0 | Tiger Stadium (0-1) | 16-13 | Lost 7 |
| » W: Earl Wilson (4-4) L: Dave McNally (3-3) | Third | 3 out |
| Wednesday, May 15 |
| » Defeated Tigers (19-11), 10-8 | Tiger Stadium (1-1) | 17-13 | |
| » W: Eddie Watt (1-2) L: Denny McLain (5-1) | Third | 2 out |
| Friday, May 17 |
| » Defeated Indians (17-14), 6-2 | Cleveland Stadium (1-0) | 18-13 | Won 2 |
| » W: Gene Brabender (3-1) L: Luis Tiant (5-3) | Second | 2 out |
| Saturday, May 18 |
| » Lost to Indians (18-14), 1-0 | Cleveland Stadium (1-1) | 18-14 | |
| » W: Stan Williams (2-1) L: Tom Phoebus (4-4) | Second | 2 out |
| Sunday, May 19 |
| » Lost to Indians (19-14), 11-6 | Cleveland Stadium (1-2) | 18-15 | Lost 2 |
| » W: Steve Hargan (3-3) L: Dave Leonhard (2-2) | Third | 4 out |
| » Lost to Indians (20-14), 2-0 | Cleveland Stadium (1-3) | 18-16 | Lost 3 |
| » W: Sonny Siebert (5-2) L: Dave McNally (3-4) | Third | 4 out |
| Monday, May 20 |
| » Defeated White Sox (15-18), 2-1 | Memorial Stadium (9-10) | 19-16 | |
| » W: Jim Hardin (5-1) L: Jack Fisher (0-2) | Third | 4 out |
| Tuesday, May 21 |
| » Lost to White Sox (16-18), 2-1 | Memorial Stadium (9-11) | 19-17 | |
| » W: Bob Locker (3-2) L: Eddie Watt (1-3) S: Hoyt Wilhelm (1) | Third | 4 out |
| Wednesday, May 22 |
| » Defeated Yankees (16-22), 4-3 | Yankee Stadium (1-0) | 20-17 | |
| » W: Moe Drabowsky (2-0) L: John Wyatt (1-3) | Third | 3 out |
| Friday, May 24 |
| » Defeated Senators (16-23), 5-3 | Memorial Stadium (10-11) | 21-17 | Won 2 |
| » W: Dave McNally (4-4) L: Phil Ortega (4-3) S: Pete Richert (1) | Second | 2 out |
| » Defeated Senators (16-24), 3-2 | Memorial Stadium (11-11) | 22-17 | Won 3 |
| » W: Eddie Watt (2-3) L: Dave Baldwin (0-1) | Second | 2 out |
| Saturday, May 25 |
| » Defeated Senators (16-25), 5-2 | Memorial Stadium (12-11) | 23-17 | Won 4 |
| » W: Jim Hardin (6-1) L: Joe Coleman (2-4) | Second | 2 out |
| Sunday, May 26 |
| » Defeated Senators (16-26), 8-7 | Memorial Stadium (13-11) | 24-17 | Won 5 |
| » W: Gene Brabender (4-1) L: Frank Bertaina (3-3) S: Moe Drabowsky (2) | Second | 1 out |
| Tuesday, May 28 |
| » Defeated White Sox (16-24), 3-2 | County Stadium (1-0) | 25-17 | Won 6 |
| » W: Pete Richert (1-1) L: Hoyt Wilhelm (1-1) | Second | ½ out |
| Wednesday, May 29 |
| » Lost to White Sox (17-24), 3-1 | Comiskey Park I (0-1) | 25-18 | |
| » W: Joe Horlen (4-5) L: Dave McNally (4-5) | Second | 1½ out |
| Thursday, May 30 |
| » Defeated White Sox (17-25), 5-0 | Comiskey Park I (1-1) | 26-18 | |
| » W: Dave Leonhard (3-2) L: Bob Priddy (0-2) | Second | 1½ out |
| Future Oriole Mike Oquist is born in LaJunta, CO. |
| Friday, May 31 |
| » Lost to Red Sox (22-23), 3-0 | Fenway Park (0-1) | 26-19 | |
| » W: Gary Bell (4-1) L: Jim Hardin (6-2) | Second | 2½ out |
| Saturday, June 1 |
| » Lost to Red Sox (23-23), 5-1 | Fenway Park (0-2) | 26-20 | Lost 2 |
| » W: Ray Culp (2-2) L: Gene Brabender (4-2) | Second | 3½ out |
| Sunday, June 2 |
| » Defeated Red Sox (23-24), 4-3 | Fenway Park (1-2) | 27-20 | |
| » W: Tom Phoebus (5-4) L: Lee Stange (2-1) | Second | 3 out |
| Monday, June 3 |
| » Defeated Angels (22-28), 2-0 | Memorial Stadium (14-11) | 28-20 | Won 2 |
| » W: Dave McNally (5-5) L: Rickey Clark (0-5) | Second | 2 out |
| Tuesday, June 4 |
| » Lost to Angels (23-28), 5-3 | Memorial Stadium (14-12) | 28-21 | |
| » W: Minnie Rojas (2-3) L: Moe Drabowsky (2-1) | Second | 2½ out |
| Wednesday, June 5 |
| » Defeated Angels (23-29), 7-1 | Memorial Stadium (15-12) | 29-21 | |
| » W: Jim Hardin (7-2) L: Clyde Wright (5-2) | Second | 2½ out |
| Thursday, June 6 |
| » Lost to Angels (24-29), 8-6 | Memorial Stadium (15-13) | 29-22 | |
| » W: Tom Burgmeier (1-2) L: Eddie Watt (2-4) S: Minnie Rojas (4) | Third | 3½ out |
| Friday, June 7 |
| » Lost to Athletics (24-27), 6-1 | Memorial Stadium (15-14) | 29-23 | Lost 2 |
| » W: Blue Moon Odom (5-4) L: Tom Phoebus (5-5) | Third | 5 out |
| » Lost to Athletics (25-27), 6-0 | Memorial Stadium (15-15) | 29-24 | Lost 3 |
| » W: Jim Nash (5-4) L: Bruce Howard (0-2) | Third | 5 out |
| Saturday, June 8 |
| » Defeated Athletics (25-28), 8-1 | Memorial Stadium (16-15) | 30-24 | |
| » W: Dave McNally (6-5) L: Catfish Hunter (5-5) | Third | 5 out |
| Monday, June 10 |
| » Defeated Senators (24-31), 4-1 | Robert F. Kennedy Stadium (4-0) | 31-24 | Won 2 |
| » W: Jim Hardin (8-2) L: Camilo Pascual (5-4) | Third | 4 out |
| Tuesday, June 11 |
| » Defeated Senators (24-32), 8-4 | Robert F. Kennedy Stadium (5-0) | 32-24 | Won 3 |
| » W: Roger Nelson (1-0) L: Frank Bertaina (4-5) S: Moe Drabowsky (3) | Second | 4½ out |
| Friday, June 14 |
| » Lost to Twins (29-31), 2-1 | Metropolitan Stadium (2-1) | 32-25 | |
| » W: Jim Roland (1-0) L: Tom Phoebus (5-6) S: Ron Perranoski (3) | Second | 6½ out |
| Saturday, June 15 |
| » Lost to Twins (30-31), 3-1 | Metropolitan Stadium (2-2) | 32-26 | Lost 2 |
| » W: Dean Chance (5-8) L: Dave McNally (6-6) | Second | 6½ out |
| Sunday, June 16 |
| » Lost to Athletics (29-31), 4-2 | Oakland-Alameda County Stadium (1-2) | 32-27 | Lost 3 |
| » W: Chuck Dobson (4-6) L: Pete Richert (1-2) | Second | 7½ out |
| » Lost to Athletics (30-31), 6-4 | Oakland-Alameda County Stadium (1-3) | 32-28 | Lost 4 |
| » W: Lew Krausse (3-7) L: Dave Leonhard (3-3) S: Catfish Hunter (1) | Second | 7½ out |
| Monday, June 17 |
| » Lost to Athletics (31-31), 3-2 | Oakland-Alameda County Stadium (1-4) | 32-29 | Lost 5 |
| » W: Paul Lindblad (4-0) L: Moe Drabowsky (2-2) | Second | 8 out |
| Tuesday, June 18 |
| » Defeated Athletics (31-32), 3-2 | Oakland-Alameda County Stadium (2-4) | 33-29 | |
| » W: Tom Phoebus (6-6) L: Jim Nash (5-5) S: Pete Richert (2) | Second | 8 out |
| Wednesday, June 19 |
| » Lost to Athletics (32-32), 5-3 | Oakland-Alameda County Stadium (2-5) | 33-30 | |
| » W: Catfish Hunter (6-5) L: Roger Nelson (1-1) | Third | 8 out |
| Friday, June 21 |
| » Defeated Angels (31-34), 4-2 | Anaheim Stadium (3-1) | 34-30 | |
| » W: Dave McNally (7-6) L: George Brunet (6-7) S: Pete Richert (3) | Second | 7½ out |
| Saturday, June 22 |
| » Lost to Angels (32-34), 5-2 | Anaheim Stadium (3-2) | 34-31 | |
| » W: Jim McGlothlin (6-4) L: Jim Hardin (8-3) S: Minnie Rojas (5) | Third | 7½ out |
| Sunday, June 23 |
| » Lost to Angels (33-34), 3-2 | Anaheim Stadium (3-3) | 34-32 | Lost 2 |
| » W: Clyde Wright (6-2) L: Tom Phoebus (6-7) | Fourth | 8 out |
| Tuesday, June 25 |
| » Defeated Red Sox (33-34), 6-0 | Memorial Stadium (17-15) | 35-32 | |
| » W: Wally Bunker (1-0) L: Ray Culp (4-3) | Fourth | 8½ out |
| Wednesday, June 26 |
| » Defeated Red Sox (33-35), 6-2 | Memorial Stadium (18-15) | 36-32 | Won 2 |
| » W: Dave McNally (8-6) L: Bill Landis (2-2) | Second | 8 out |
| Thursday, June 27 |
| » Lost to Twins (37-33), 2-0 | Memorial Stadium (18-16) | 36-33 | |
| » W: Dave Boswell (7-6) L: Jim Hardin (8-4) | Third | 8½ out |
| Friday, June 28 |
| » Lost to Twins (38-33), 5-2 | Memorial Stadium (18-17) | 36-34 | Lost 2 |
| » W: Jim Kaat (5-4) L: Tom Phoebus (6-8) S: Al Worthington (13) | Fifth | 9½ out |
| Saturday, June 29 |
| » Defeated Twins (38-34), 5-1 | Memorial Stadium (19-17) | 37-34 | |
| » W: Pete Richert (2-2) L: Jim Merritt (5-7) | Fifth | 9½ out |
| Sunday, June 30 |
| » Defeated Twins (38-35), 6-4 | Memorial Stadium (20-17) | 38-34 | Won 2 |
| » W: Eddie Watt (3-4) L: Al Worthington (2-3) S: Moe Drabowsky (4) | Third | 8½ out |
| Monday, July 1 |
| » Lost to White Sox (32-40), 6-3 | Memorial Stadium (20-18) | 38-35 | |
| » W: Wilbur Wood (6-3) L: Dave McNally (8-7) S: Bob Locker (7) | Third | 9½ out |
| Wednesday, July 3 |
| » Defeated White Sox (32-41), 3-1 | Memorial Stadium (21-18) | 39-35 | |
| » W: Jim Hardin (9-4) L: Hoyt Wilhelm (2-2) | Third | 9½ out |
| » Defeated White Sox (32-42), 1-0 | Memorial Stadium (22-18) | 40-35 | Won 2 |
| » W: Tom Phoebus (7-8) L: Gary Peters (3-9) | Third | 9½ out |
| Thursday, July 4 |
| » Defeated White Sox (32-43), 4-3 | Memorial Stadium (23-18) | 41-35 | Won 3 |
| » W: Eddie Watt (4-4) L: Wilbur Wood (6-4) | Third | 9½ out |
| Friday, July 5 |
| » Lost to Yankees (35-41), 2-1 | Yankee Stadium (1-1) | 41-36 | |
| » W: Fritz Peterson (5-3) L: Dave McNally (8-8) | Third | 10½ out |
| Saturday, July 6 |
| » Defeated Yankees (35-42), 5-1 | Yankee Stadium (2-1) | 42-36 | |
| » W: Dave Leonhard (4-3) L: Steve Barber (1-3) | Third | 9½ out |
| Sunday, July 7 |
| » Lost to Yankees (36-42), 3-1 | Yankee Stadium (2-2) | 42-37 | |
| » W: Mel Stottlemyre (11-5) L: Jim Hardin (9-5) | Third | 10½ out |
| » Defeated Yankees (36-43), 3-2 | Yankee Stadium (3-2) | 43-37 | |
| » W: Tom Phoebus (8-8) L: Stan Bahnsen (7-5) S: Moe Drabowsky (5) | Third | 10½ out |
| Thursday, July 11 |
| » Defeated Senators (30-48), 2-0 | Memorial Stadium (24-18) | 44-37 | Won 2 |
| » Manager: Earl Weaver |
| » W: Dave McNally (9-8) L: Joe Coleman (5-10) | Second | 9½ out |
| Friday, July 12 |
| » Defeated Senators (30-49), 3-2 | Memorial Stadium (25-18) | 45-37 | Won 3 |
| » W: Jim Hardin (10-5) L: Camilo Pascual (8-5) S: Pete Richert (4) | Second | 9½ out |
| Saturday, July 13 |
| » Defeated Senators (30-50), 3-1 | Memorial Stadium (26-18) | 46-37 | Won 4 |
| » W: Tom Phoebus (9-8) L: Jim Hannan (3-2) | Second | 8½ out |
| Sunday, July 14 |
| » Defeated Yankees (39-44), 6-4 | Memorial Stadium (27-18) | 47-37 | Won 5 |
| » W: Dave Leonhard (5-3) L: Stan Bahnsen (7-6) S: Eddie Watt (5) | Second | 7½ out |
| Future Oriole Derrick May is born in Rochester, NY. |
| Monday, July 15 |
| » Defeated Yankees (39-45), 8-2 | Memorial Stadium (28-18) | 48-37 | Won 6 |
| » W: Dave McNally (10-8) L: Fritz Peterson (6-4) S: Moe Drabowsky (6) | Second | 6½ out |
| Tuesday, July 16 |
| » Defeated White Sox (37-48), 4-2 | Comiskey Park I (2-1) | 49-37 | Won 7 |
| » W: Jim Hardin (11-5) L: Tommy John (7-2) | Second | 6½ out |
| Wednesday, July 17 |
| » Lost to White Sox (38-48), 1-0 | Comiskey Park I (2-2) | 49-38 | |
| » W: Joe Horlen (6-8) L: Tom Phoebus (9-9) S: Hoyt Wilhelm (5) | Second | 6½ out |
| Thursday, July 18 |
| » Lost to White Sox (39-48), 2-1 | Comiskey Park I (2-3) | 49-39 | Lost 2 |
| » W: Jack Fisher (4-5) L: Dave Leonhard (5-4) S: Hoyt Wilhelm (6) | Third | 7½ out |
| Friday, July 19 |
| » Lost to Tigers (59-33), 5-4 | Tiger Stadium (1-2) | 49-40 | Lost 3 |
| » W: Pat Dobson (3-1) L: Moe Drabowsky (2-3) | Third | 8½ out |
| Saturday, July 20 |
| » Defeated Tigers (59-34), 5-3 | Tiger Stadium (2-2) | 50-40 | |
| » W: Dave McNally (11-8) L: Denny McLain (18-3) S: John O'Donoghue (2) | Third | 7½ out |
| Sunday, July 21 |
| » Defeated Tigers (59-35), 5-2 | Tiger Stadium (3-2) | 51-40 | Won 2 |
| » W: Jim Hardin (12-5) L: Earl Wilson (7-8) | Second | 5½ out |
| » Defeated Tigers (59-36), 4-1 | Tiger Stadium (4-2) | 52-40 | Won 3 |
| » W: Tom Phoebus (10-9) L: Pat Dobson (3-2) S: Gene Brabender (1) | Second | 5½ out |
| Monday, July 22 |
| » Lost to Indians (55-42), 7-3 | Memorial Stadium (28-19) | 52-41 | |
| » W: Sonny Siebert (11-5) L: Mike Adamson (0-1) S: Eddie Fisher (2) | Third | 6 out |
| Tuesday, July 23 |
| » Defeated Indians (55-43), 8-6 | Memorial Stadium (29-19) | 53-41 | |
| » W: John Morris (1-0) L: Stan Williams (7-5) S: Moe Drabowsky (7) | Second | 6 out |
| Wednesday, July 24 |
| » Defeated Indians (55-44), 1-0 | Memorial Stadium (30-19) | 54-41 | Won 2 |
| » W: Dave McNally (12-8) L: Luis Tiant (16-6) | Second | 5 out |
| Friday, July 26 |
| » Lost to Tigers (62-37), 4-1 | Memorial Stadium (30-20) | 54-42 | |
| » W: Earl Wilson (8-8) L: Jim Hardin (12-6) S: Daryl Patterson (3) | Second | 6½ out |
| Saturday, July 27 |
| » Lost to Tigers (63-37), 9-0 | Memorial Stadium (30-21) | 54-43 | Lost 2 |
| » W: Denny McLain (20-3) L: Tom Phoebus (10-10) | Second | 7½ out |
| Sunday, July 28 |
| » Defeated Tigers (63-38), 5-1 | Memorial Stadium (31-21) | 55-43 | |
| » W: Dave McNally (13-8) L: Mickey Lolich (7-7) | Second | 6½ out |
| Monday, July 29 |
| » Lost to Red Sox (52-46), 3-2 | Fenway Park (1-3) | 55-44 | |
| » W: Ray Culp (7-4) L: Moe Drabowsky (2-4) | Second | 7 out |
| » Lost to Red Sox (53-46), 8-3 | Fenway Park (1-4) | 55-45 | Lost 2 |
| » W: Juan Pizarro (4-2) L: Mike Adamson (0-2) | Second | 7 out |
| Tuesday, July 30 |
| » Defeated Red Sox (53-47), 8-3 | Fenway Park (2-4) | 56-45 | |
| » W: Jim Hardin (13-6) L: Dick Ellsworth (9-6) | Second | 7 out |
| Wednesday, July 31 |
| » Defeated Indians (58-48), 4-2 | Cleveland Stadium (2-3) | 57-45 | Won 2 |
| » W: Tom Phoebus (11-10) L: Sonny Siebert (11-7) S: Gene Brabender (2) | Second | 7 out |
| Thursday, August 1 |
| » Defeated Indians (58-49), 5-1 | Cleveland Stadium (3-3) | 58-45 | Won 3 |
| » W: Dave McNally (14-8) L: Luis Tiant (17-7) | Second | 6 out |
| Friday, August 2 |
| » Defeated Yankees (49-53), 4-1 | Yankee Stadium (4-2) | 59-45 | Won 4 |
| » W: John Morris (2-0) L: Fritz Peterson (6-7) S: Eddie Watt (6) | Second | 6 out |
| Saturday, August 3 |
| » Lost to Yankees (50-53), 3-1 | Yankee Stadium (4-3) | 59-46 | |
| » W: Mel Stottlemyre (14-8) L: Jim Hardin (13-7) | Second | 6 out |
| Sunday, August 4 |
| » Defeated Yankees (50-54), 5-3 | Yankee Stadium (5-3) | 60-46 | |
| » W: Tom Phoebus (12-10) L: Steve Barber (5-4) S: Eddie Watt (7) | Second | 6 out |
| Monday, August 5 |
| » Defeated Yankees (50-55), 5-3 | Yankee Stadium (6-3) | 61-46 | Won 2 |
| » W: Pete Richert (3-2) L: Dooley Womack (2-6) | Second | 5½ out |
| Tuesday, August 6 |
| » Lost to Twins (51-56), 5-4 | Memorial Stadium (31-22) | 61-47 | |
| » W: Jim Merritt (7-12) L: Gene Brabender (4-3) S: Ron Perranoski (5) | Second | 6½ out |
| Wednesday, August 7 |
| » Defeated Twins (51-57), 3-0 | Memorial Stadium (32-22) | 62-47 | |
| » W: Jim Hardin (14-7) L: Dave Boswell (8-9) | Second | 6½ out |
| » Defeated Twins (51-58), 9-6 | Memorial Stadium (33-22) | 63-47 | Won 2 |
| » W: Pete Richert (4-2) L: Ron Perranoski (6-5) S: Eddie Watt (8) | Second | 6½ out |
| Thursday, August 8 |
| » Defeated Twins (51-59), 10-3 | Memorial Stadium (34-22) | 64-47 | Won 3 |
| » W: Tom Phoebus (13-10) L: Jim Kaat (8-8) S: Dave Leonhard (1) | Second | 6½ out |
| Friday, August 9 |
| » Defeated Angels (52-62), 3-0 | Memorial Stadium (35-22) | 65-47 | Won 4 |
| » W: Dave McNally (15-8) L: Bill Harrelson (0-3) | Second | 5½ out |
| Saturday, August 10 |
| » Defeated Angels (52-63), 1-0 | Memorial Stadium (36-22) | 66-47 | Won 5 |
| » W: Gene Brabender (5-3) L: Tom Murphy (4-5) | Second | 5½ out |
| Sunday, August 11 |
| » Lost to Angels (53-63), 11-1 | Memorial Stadium (36-23) | 66-48 | |
| » W: Jim McGlothlin (7-10) L: Jim Hardin (14-8) | Second | 7 out |
| Monday, August 12 |
| » Defeated Athletics (60-56), 3-1 | Oakland-Alameda County Stadium (3-5) | 67-48 | |
| » W: Pete Richert (5-2) L: Lew Krausse (8-9) S: Gene Brabender (3) | Second | 7 out |
| Tuesday, August 13 |
| » Defeated Athletics (60-57), 6-5 | Oakland-Alameda County Stadium (4-5) | 68-48 | Won 2 |
| » W: Pete Richert (6-2) L: Catfish Hunter (9-10) S: Eddie Watt (9) | Second | 6 out |
| Wednesday, August 14 |
| » Lost to Athletics (61-57), 4-1 | Oakland-Alameda County Stadium (4-6) | 68-49 | |
| » W: Chuck Dobson (10-11) L: Dave Leonhard (5-5) S: Diego Segui (2) | Second | 7 out |
| Thursday, August 15 |
| » Defeated Twins (55-62), 4-3 | Metropolitan Stadium (3-2) | 69-49 | |
| » W: Jim Hardin (15-8) L: Dean Chance (11-11) | Second | 7 out |
| » Lost to Twins (56-62), 2-1 | Metropolitan Stadium (3-3) | 69-50 | |
| » W: Ron Perranoski (7-5) L: Gene Brabender (5-4) | Second | 7 out |
| Friday, August 16 |
| » Lost to Twins (57-62), 5-2 | Metropolitan Stadium (3-4) | 69-51 | Lost 2 |
| » W: Jim Kaat (9-9) L: Tom Phoebus (13-11) | Second | 8 out |
| Saturday, August 17 |
| » Defeated Twins (57-63), 8-2 | Metropolitan Stadium (4-4) | 70-51 | |
| » W: Dave McNally (16-8) L: Bob Miller (0-3) | Second | 8 out |
| Sunday, August 18 |
| » Defeated Twins (57-64), 7-1 | Metropolitan Stadium (5-4) | 71-51 | Won 2 |
| » W: Dave Leonhard (6-5) L: Jim Merritt (8-14) | Second | 7 out |
| Monday, August 19 |
| » Defeated Angels (56-68), 1-0 | Anaheim Stadium (4-3) | 72-51 | Won 3 |
| » W: Jim Hardin (16-8) L: Jim McGlothlin (8-11) | Second | 6½ out |
| Tuesday, August 20 |
| » Lost to Angels (57-68), 7-2 | Anaheim Stadium (4-4) | 72-52 | |
| » W: Clyde Wright (8-3) L: Tom Phoebus (13-12) | Second | 7 out |
| Wednesday, August 21 |
| » Defeated Angels (57-69), 4-3 | Anaheim Stadium (5-4) | 73-52 | |
| » W: Gene Brabender (6-4) L: Marty Pattin (3-4) | Second | 7 out |
| Friday, August 23 |
| » Lost to Red Sox (69-60), 4-3 | Memorial Stadium (36-24) | 73-53 | |
| » W: Juan Pizarro (7-4) L: Dave Leonhard (6-6) | Second | 7½ out |
| Saturday, August 24 |
| » Defeated Red Sox (69-61), 6-3 | Memorial Stadium (37-24) | 74-53 | |
| » W: Jim Hardin (17-8) L: Dave Morehead (1-3) | Second | 6½ out |
| Sunday, August 25 |
| » Defeated Red Sox (69-62), 3-2 | Memorial Stadium (38-24) | 75-53 | Won 2 |
| » W: Roger Nelson (2-1) L: Jerry Stephenson (2-8) | Second | 5 out |
| Monday, August 26 |
| » Defeated Athletics (66-64), 8-2 | Memorial Stadium (39-24) | 76-53 | Won 3 |
| » W: Dave McNally (17-8) L: Chuck Dobson (10-12) | Second | 5½ out |
| » Lost to Athletics (67-64), 2-0 | Memorial Stadium (39-25) | 76-54 | |
| » W: Catfish Hunter (11-11) L: Gene Brabender (6-5) S: Diego Segui (4) | Second | 5½ out |
| Tuesday, August 27 |
| » Defeated Athletics (67-65), 5-3 | Memorial Stadium (40-25) | 77-54 | |
| » W: Eddie Watt (5-4) L: Jack Aker (3-3) | Second | 4 out |
| » Defeated Athletics (67-66), 7-2 | Memorial Stadium (41-25) | 78-54 | Won 2 |
| » W: Wally Bunker (2-0) L: Ed Sprague (3-3) | Second | 4 out |
| Wednesday, August 28 |
| » Lost to Senators (51-80), 3-2 | Memorial Stadium (41-26) | 78-55 | |
| » W: Jim Hannan (8-3) L: Jim Hardin (17-9) S: Dennis Higgins (9) | Second | 5 out |
| Thursday, August 29 |
| » Lost to Senators (52-80), 5-4 | Memorial Stadium (41-27) | 78-56 | Lost 2 |
| » W: Dick Bosman (2-8) L: Eddie Watt (5-5) | Second | 6 out |
| Friday, August 30 |
| » Lost to Tigers (85-50), 9-1 | Tiger Stadium (4-3) | 78-57 | Lost 3 |
| » W: Earl Wilson (12-11) L: Tom Phoebus (13-13) | Second | 7 out |
| Saturday, August 31 |
| » Defeated Tigers (85-51), 5-1 | Tiger Stadium (5-3) | 79-57 | |
| » W: Dave McNally (18-8) L: John Hiller (6-5) | Second | 6 out |
| Sunday, September 1 |
| » Lost to Tigers (86-51), 7-3 | Tiger Stadium (5-4) | 79-58 | |
| » W: Denny McLain (27-5) L: Jim Hardin (17-10) | Second | 7 out |
| Monday, September 2 |
| » Lost to Yankees (69-68), 4-2 | Memorial Stadium (41-28) | 79-59 | Lost 2 |
| » W: Mel Stottlemyre (18-11) L: Dave Leonhard (6-7) S: Steve Hamilton (11) | Second | 7 out |
| » Defeated Yankees (69-69), 4-3 | Memorial Stadium (42-28) | 80-59 | |
| » W: Moe Drabowsky (3-4) L: Lindy McDaniel (2-1) | Second | 7 out |
| Tuesday, September 3 |
| » Lost to Yankees (70-69), 6-1 | Memorial Stadium (42-29) | 80-60 | |
| » W: Fritz Peterson (9-9) L: Tom Phoebus (13-14) S: Dooley Womack (2) | Second | 8 out |
| Wednesday, September 4 |
| » Defeated Yankees (70-70), 6-3 | Memorial Stadium (43-29) | 81-60 | |
| » W: Dave McNally (19-8) L: Stan Bahnsen (14-10) | Second | 8 out |
| Friday, September 6 |
| » Lost to White Sox (61-82), 3-2 | Memorial Stadium (43-30) | 81-61 | |
| » W: Hoyt Wilhelm (3-4) L: Pete Richert (6-3) S: Bob Locker (9) | Second | 9 out |
| » Major-league debuts: Carlos May (White Sox) |
| Saturday, September 7 |
| » Defeated White Sox (61-83), 4-0 | Memorial Stadium (44-30) | 82-61 | |
| » W: Tom Phoebus (14-14) L: Cisco Carlos (4-14) | Second | 8 out |
| Sunday, September 8 |
| » Defeated White Sox (61-84), 3-2 | Memorial Stadium (45-30) | 83-61 | Won 2 |
| » W: Dave McNally (20-8) L: Jack Fisher (7-10) | Second | 7 out |
| Monday, September 9 |
| » Lost to Senators (57-87), 6-2 | Robert F. Kennedy Stadium (5-1) | 83-62 | |
| » W: Jim Hannan (10-4) L: Gene Brabender (6-6) S: Dennis Higgins (10) | Second | 8 out |
| Tuesday, September 10 |
| » Major-league debuts: Al Santorini (Braves) |
| Wednesday, September 11 |
| » Defeated Senators (57-88), 6-1 | Robert F. Kennedy Stadium (6-1) | 84-62 | |
| » W: Jim Hardin (18-10) L: Camilo Pascual (12-11) | Second | 8 out |
| » Defeated Senators (57-89), 4-1 | Robert F. Kennedy Stadium (7-1) | 85-62 | Won 2 |
| » W: Moe Drabowsky (4-4) L: Bob Humphreys (4-6) S: Pete Richert (5) | Second | 8 out |
| » Major-league debuts: Dick Billings (Senators) |
| Thursday, September 12 |
| » Lost to Senators (58-89), 4-1 | Robert F. Kennedy Stadium (7-2) | 85-63 | |
| » W: Frank Bertaina (6-13) L: Dave McNally (20-9) S: Dennis Higgins (11) | Second | 8½ out |
| Friday, September 13 |
| » Lost to Indians (80-71), 10-2 | Cleveland Stadium (3-4) | 85-64 | Lost 2 |
| » W: Mike Paul (3-8) L: Gene Brabender (6-7) | Second | 9½ out |
| Saturday, September 14 |
| » Defeated Indians (80-72), 5-3 | Cleveland Stadium (4-4) | 86-64 | |
| » W: Roger Nelson (3-1) L: Steve Bailey (0-1) S: Eddie Watt (10) | Second | 9½ out |
| Sunday, September 15 |
| » Lost to Indians (81-72), 2-0 | Cleveland Stadium (4-5) | 86-65 | |
| » W: Stan Williams (13-10) L: Jim Hardin (18-11) | Second | 10½ out |
| Monday, September 16 |
| » Defeated Red Sox (79-72), 8-1 | Fenway Park (3-4) | 87-65 | |
| » W: Tom Phoebus (15-14) L: Jim Lonborg (5-8) S: Eddie Watt (11) | Second | 10½ out |
| Tuesday, September 17 |
| » Lost |