| Tuesday, January 9 |
| Future Indian Tom Kramer is born in Cincinnati, OH. |
| Friday, January 26 |
| Former Indian Eddie Phillips dies in Buffalo, NY at the age of 67. |
| Thursday, February 1 |
| Future Indian Kent Mercker is born in Indianapolis, IN. |
| Monday, February 5 |
| Future Indian Roberto Alomar is born in Ponce, P.R. |
| Wednesday, February 14 |
| Future Indian Scott Scudder is born in Paris, TX. |
| Sunday, February 18 |
| Former Indian Ben Egan dies in Sherrill, NY at the age of 85. |
| Thursday, March 7 |
| Future Indian Denis Boucher is born in Montreal, PQ. Future Indian Jeff Kent is born in Bellflower, CA. |
| Tuesday, March 26 |
| Future Indian Jose Vizcaino is born in San Cristobal, D.R. |
| Sunday, March 31 |
| Former Indian Grover Lowdermilk dies in Odin, IL at the age of 84. |
| Wednesday, April 10 |
| » Defeated White Sox (0-1), 9-0 | Comiskey Park I (1-0) | 1-0 | |
| » W: Sonny Siebert (1-0) L: Joe Horlen (0-1) | First | -- |
| Thursday, April 11 |
| » Lost to Angels (1-1), 7-5 | Cleveland Stadium (0-1) | 1-1 | |
| » W: Bobby Locke (1-0) L: Luis Tiant (0-1) S: Minnie Rojas (1) | Third | 1 out |
| » Major-league debuts: Dave Nelson (Indians) |
| Saturday, April 13 |
| » Lost to Red Sox (2-1), 3-1 | Cleveland Stadium (0-2) | 1-2 | Lost 2 |
| » W: Gary Waslewski (1-0) L: Steve Hargan (0-1) S: Lee Stange (1) | Fifth | 2 out |
| Sunday, April 14 |
| » Defeated Red Sox (2-2), 7-4 | Cleveland Stadium (1-2) | 2-2 | |
| » W: Sonny Siebert (2-0) L: Jerry Stephenson (0-1) S: Eddie Fisher (1) | Fourth | 2 out |
| Future Indian Jesse Levis is born in Philadelphia, PA. Former Indian Al Benton dies in Lynwood, CA at the age of 58. |
| Tuesday, April 16 |
| » Defeated White Sox (0-4), 3-1 | Cleveland Stadium (2-2) | 3-2 | Won 2 |
| » W: Luis Tiant (1-1) L: Joe Horlen (0-2) | Third | 2 out |
| Wednesday, April 17 |
| » Lost to Tigers (5-1), 4-3 | Tiger Stadium (0-1) | 3-3 | |
| » W: Jon Warden (2-0) L: Eddie Fisher (0-1) | Fourth | 3 out |
| Thursday, April 18 |
| » Lost to Tigers (6-1), 5-0 | Tiger Stadium (0-2) | 3-4 | Lost 2 |
| » W: Joe Sparma (1-0) L: Steve Hargan (0-2) | Fourth | 3 out |
| Friday, April 19 |
| » Lost to Red Sox (5-3), 9-2 | Fenway Park (0-1) | 3-5 | Lost 3 |
| » W: Gary Waslewski (2-0) L: Sonny Siebert (2-1) | Fifth | 3½ out |
| Saturday, April 20 |
| » Lost to Red Sox (6-3), 3-2 | Fenway Park (0-2) | 3-6 | Lost 4 |
| » W: Jerry Stephenson (1-1) L: Luis Tiant (1-2) | Seventh | 4½ out |
| Sunday, April 21 |
| » Defeated Red Sox (6-4), 7-0 | Fenway Park (1-2) | 4-6 | |
| » W: Sam McDowell (1-0) L: Ray Culp (0-2) | Sixth | 5 out |
| Wednesday, April 24 |
| » Defeated Tigers (9-2), 2-0 | Cleveland Stadium (3-2) | 5-6 | Won 2 |
| » W: Steve Hargan (1-2) L: Joe Sparma (1-1) | Sixth | 4 out |
| Friday, April 26 |
| » Lost to Senators (8-6), 5-4 | Robert F. Kennedy Stadium (0-1) | 5-7 | |
| » W: Dennis Higgins (2-1) L: Tommy Gramly (0-1) | Eighth | 4 out |
| Saturday, April 27 |
| » Lost to Senators (9-6), 2-1 | Robert F. Kennedy Stadium (0-2) | 5-8 | Lost 2 |
| » W: Camilo Pascual (3-1) L: Sam McDowell (1-1) S: Dave Baldwin (3) | Eighth | 5 out |
| Sunday, April 28 |
| » Lost to Senators (10-6), 1-0 | Robert F. Kennedy Stadium (0-3) | 5-9 | Lost 3 |
| » W: Phil Ortega (3-1) L: Stan Williams (0-1) | Seventh | 5 out |
| » Defeated Senators (10-7), 2-0 | Robert F. Kennedy Stadium (1-3) | 6-9 | |
| » W: Luis Tiant (2-2) L: Barry Moore (0-1) | Seventh | 5 out |
| Monday, April 29 |
| » Lost to Angels (7-10), 3-2 | Cleveland Stadium (3-3) | 6-10 | |
| » W: Jim McGlothlin (1-2) L: Steve Hargan (1-3) S: Jack Hamilton (1) | Eighth | 6 out |
| Tuesday, April 30 |
| » Lost to Angels (8-10), 5-3 | Cleveland Stadium (3-4) | 6-11 | Lost 2 |
| » W: George Brunet (2-2) L: Sonny Siebert (2-2) S: Clyde Wright (2) | Eighth | 6 out |
| Wednesday, May 1 |
| » Defeated Athletics (8-11), 3-1 | Cleveland Stadium (4-4) | 7-11 | |
| » W: Sam McDowell (2-1) L: Blue Moon Odom (2-2) | Ninth | 6 out |
| Friday, May 3 |
| » Defeated Twins (12-8), 4-0 | Cleveland Stadium (5-4) | 8-11 | Won 2 |
| » W: Luis Tiant (3-2) L: Jim Perry (3-2) | Eighth | 5 out |
| Saturday, May 4 |
| » Defeated Twins (12-9), 2-0 | Cleveland Stadium (6-4) | 9-11 | Won 3 |
| » W: Steve Hargan (2-3) L: Dave Boswell (3-2) | Seventh | 5 out |
| Sunday, May 5 |
| » Defeated Twins (12-10), 2-1 | Cleveland Stadium (7-4) | 10-11 | Won 4 |
| » W: Sonny Siebert (3-2) L: Al Worthington (0-1) S: Stan Williams (1) | Sixth | 5 out |
| Monday, May 6 |
| » Defeated Yankees (10-14), 3-2 | Yankee Stadium (1-0) | 11-11 | Won 5 |
| » W: Sam McDowell (3-1) L: Mel Stottlemyre (3-3) | Fourth | 5 out |
| Tuesday, May 7 |
| » Defeated Yankees (10-15), 8-0 | Yankee Stadium (2-0) | 12-11 | Won 6 |
| » W: Luis Tiant (4-2) L: Jim Bouton (0-1) | Fourth | 4 out |
| Wednesday, May 8 |
| » Lost to Yankees (11-15), 2-1 | Yankee Stadium (2-1) | 12-12 | |
| » W: Joe Verbanic (1-0) L: Eddie Fisher (0-2) | Fourth | 4 out |
| Friday, May 10 |
| » Defeated Orioles (16-9), 12-0 | Memorial Stadium (1-0) | 13-12 | |
| » W: Sonny Siebert (4-2) L: Jim Hardin (4-1) | Fourth | 3½ out |
| Saturday, May 11 |
| » Defeated Orioles (16-10), 4-3 | Memorial Stadium (2-0) | 14-12 | Won 2 |
| » W: Sam McDowell (4-1) L: Eddie Watt (0-2) | Third | 3½ out |
| Sunday, May 12 |
| » Defeated Orioles (16-11), 2-0 | Memorial Stadium (3-0) | 15-12 | Won 3 |
| » W: Luis Tiant (5-2) L: Tom Phoebus (4-3) | Second | 2 out |
| » Defeated Orioles (16-12), 4-1 | Memorial Stadium (4-0) | 16-12 | Won 4 |
| » W: Stan Williams (1-1) L: Dave Leonhard (2-1) | Second | 2 out |
| Future Indian Mark Clark is born in Bath, IL. |
| Tuesday, May 14 |
| » Defeated Yankees (13-18), 4-2 | Cleveland Stadium (8-4) | 17-12 | Won 5 |
| » W: Eddie Fisher (1-2) L: Joe Verbanic (1-1) | Second | 2 out |
| Wednesday, May 15 |
| » Tied Yankees, 2-2 | Cleveland Stadium (8-4) | 17-12 | |
| » Starters: Stan Bahnsen vs Sonny Siebert | Second | 1½ out |
| Thursday, May 16 |
| » Lost to Senators (14-17), 4-1 | Cleveland Stadium (8-5) | 17-13 | |
| » W: Barry Moore (1-3) L: Sam McDowell (4-2) S: Dennis Higgins (1) | Second | 2 out |
| Friday, May 17 |
| » Lost to Orioles (18-13), 6-2 | Cleveland Stadium (8-6) | 17-14 | Lost 2 |
| » W: Gene Brabender (3-1) L: Luis Tiant (5-3) | Third | 3 out |
| Saturday, May 18 |
| » Defeated Orioles (18-14), 1-0 | Cleveland Stadium (9-6) | 18-14 | |
| » W: Stan Williams (2-1) L: Tom Phoebus (4-4) | Second | 2 out |
| Sunday, May 19 |
| » Defeated Orioles (18-15), 11-6 | Cleveland Stadium (10-6) | 19-14 | Won 2 |
| » W: Steve Hargan (3-3) L: Dave Leonhard (2-2) | Second | 2 out |
| » Defeated Orioles (18-16), 2-0 | Cleveland Stadium (11-6) | 20-14 | Won 3 |
| » W: Sonny Siebert (5-2) L: Dave McNally (3-4) | Second | 2 out |
| Tuesday, May 21 |
| » Defeated Athletics (15-21), 1-0 | Oakland-Alameda County Stadium (1-0) | 21-14 | Won 4 |
| » W: Sam McDowell (5-2) L: Chuck Dobson (2-4) | Second | 2 out |
| » Lost to Athletics (16-21), 2-0 | Oakland-Alameda County Stadium (1-1) | 21-15 | |
| » W: Blue Moon Odom (3-3) L: Luis Tiant (5-4) | Second | 2 out |
| Wednesday, May 22 |
| » Lost to Athletics (17-21), 2-0 | Oakland-Alameda County Stadium (1-2) | 21-16 | Lost 2 |
| » W: Jim Nash (2-4) L: Stan Williams (2-2) | Second | 2 out |
| Thursday, May 23 |
| » Defeated Angels (18-21), 9-2 | Anaheim Stadium (1-0) | 22-16 | |
| » W: Sonny Siebert (6-2) L: Sammy Ellis (3-5) | Second | 1½ out |
| Friday, May 24 |
| » Lost to Angels (19-21), 2-1 | Anaheim Stadium (1-1) | 22-17 | |
| » W: George Brunet (5-3) L: Steve Hargan (3-4) | Second | 2 out |
| Future Indian Jerry Dipoto is born in Jersey City, NJ. |
| Saturday, May 25 |
| » Lost to Angels (20-21), 5-1 | Anaheim Stadium (1-2) | 22-18 | Lost 2 |
| » W: Jim McGlothlin (4-2) L: Sam McDowell (5-3) | Third | 3 out |
| Sunday, May 26 |
| » Defeated Angels (20-22), 5-2 | Anaheim Stadium (2-2) | 23-18 | |
| » W: Luis Tiant (6-4) L: Marty Pattin (0-1) | Third | 2 out |
| Monday, May 27 |
| » Defeated Twins (22-19), 3-1 | Metropolitan Stadium (1-0) | 24-18 | Won 2 |
| » W: Stan Williams (3-2) L: Dean Chance (4-5) S: Mike Paul (1) | Third | 1 out |
| » Major-league debuts: Mike Paul (Indians) |
| Tuesday, May 28 |
| » Lost to Twins (23-19), 3-1 | Metropolitan Stadium (1-1) | 24-19 | |
| » W: Jim Perry (5-3) L: Sonny Siebert (6-3) S: Al Worthington (10) | Third | 2 out |
| Wednesday, May 29 |
| » Lost to Twins (24-19), 1-0 | Metropolitan Stadium (1-2) | 24-20 | Lost 2 |
| » W: Dave Boswell (4-5) L: Steve Hargan (3-5) | Fourth | 3 out |
| Thursday, May 30 |
| » Defeated Twins (24-20), 3-1 | Metropolitan Stadium (2-2) | 25-20 | |
| » W: Sam McDowell (6-3) L: Jim Kaat (2-2) | Third | 3 out |
| Friday, May 31 |
| » Defeated Senators (17-28), 8-3 | Cleveland Stadium (12-6) | 26-20 | Won 2 |
| » W: Luis Tiant (7-4) L: Phil Ortega (4-4) | Third | 3 out |
| Saturday, June 1 |
| » Lost to Senators (18-28), 6-2 | Cleveland Stadium (12-7) | 26-21 | |
| » W: Darold Knowles (1-0) L: Stan Williams (3-3) | Third | 4 out |
| Sunday, June 2 |
| » Defeated Senators (18-29), 10-5 | Cleveland Stadium (13-7) | 27-21 | |
| » W: Steve Hargan (4-5) L: Frank Bertaina (3-4) S: Billy Rohr (1) | Third | 4 out |
| » Lost to Senators (19-29), 11-3 | Cleveland Stadium (13-8) | 27-22 | |
| » W: Jim Hannan (1-0) L: Sonny Siebert (6-4) | Third | 4 out |
| Monday, June 3 |
| » Defeated White Sox (21-26), 3-2 | Cleveland Stadium (14-8) | 28-22 | |
| » W: Hal Kurtz (1-0) L: Jack Fisher (1-3) | Third | 3 out |
| Tuesday, June 4 |
| » Defeated White Sox (21-27), 2-1 | Cleveland Stadium (15-8) | 29-22 | Won 2 |
| » W: Luis Tiant (8-4) L: Gary Peters (2-6) | Third | 2½ out |
| Wednesday, June 5 |
| » Defeated White Sox (21-28), 1-0 | Cleveland Stadium (16-8) | 30-22 | Won 3 |
| » W: Stan Williams (4-3) L: Cisco Carlos (2-6) S: Hal Kurtz (1) | Third | 2½ out |
| Thursday, June 6 |
| » Defeated White Sox (21-29), 2-1 | Cleveland Stadium (17-8) | 31-22 | Won 4 |
| » W: Billy Rohr (1-0) L: Don McMahon (1-1) | Second | 2½ out |
| Friday, June 7 |
| » Lost to Tigers (34-19), 5-4 | Tiger Stadium (0-3) | 31-23 | |
| » W: Fred Lasher (4-1) L: Mike Paul (0-1) | Second | 3½ out |
| Saturday, June 8 |
| » Lost to Tigers (35-19), 3-1 | Tiger Stadium (0-4) | 31-24 | Lost 2 |
| » W: Mickey Lolich (4-3) L: Sam McDowell (6-4) | Second | 4½ out |
| Future Indian Dave Mlicki is born in Cleveland, OH. |
| Sunday, June 9 |
| » Defeated Tigers (35-20), 2-0 | Tiger Stadium (1-4) | 32-24 | |
| » W: Luis Tiant (9-4) L: Denny McLain (9-2) | Second | 3½ out |
| Monday, June 10 |
| » Defeated Athletics (25-29), 7-2 | Cleveland Stadium (18-8) | 33-24 | Won 2 |
| » W: Stan Williams (5-3) L: Lew Krausse (2-7) S: Mike Paul (2) | Second | 3 out |
| Tuesday, June 11 |
| » Lost to Athletics (26-29), 2-0 | Cleveland Stadium (18-9) | 33-25 | |
| » W: Chuck Dobson (3-6) L: Sonny Siebert (6-5) | Third | 4½ out |
| Wednesday, June 12 |
| » Lost to Athletics (27-29), 7-0 | Cleveland Stadium (18-10) | 33-26 | Lost 2 |
| » W: Blue Moon Odom (6-4) L: Steve Hargan (4-6) | Third | 5½ out |
| Thursday, June 13 |
| » Lost to Athletics (28-29), 1-0 | Cleveland Stadium (18-11) | 33-27 | Lost 3 |
| » W: Ed Sprague (2-0) L: Sam McDowell (6-5) | Third | 6½ out |
| Friday, June 14 |
| » Lost to Red Sox (27-29), 7-2 | Cleveland Stadium (18-12) | 33-28 | Lost 4 |
| » W: Dick Ellsworth (5-4) L: Luis Tiant (9-5) | Third | 7½ out |
| Saturday, June 15 |
| » Lost to Red Sox (28-29), 9-3 | Cleveland Stadium (18-13) | 33-29 | Lost 5 |
| » W: Ray Culp (3-2) L: Stan Williams (5-4) S: Gary Waslewski (1) | Third | 7½ out |
| Sunday, June 16 |
| » Lost to Red Sox (29-29), 5-3 | Cleveland Stadium (18-14) | 33-30 | Lost 6 |
| » W: Bill Landis (1-1) L: Mike Paul (0-2) S: Lee Stange (5) | Third | 8 out |
| Monday, June 17 |
| » Lost to White Sox (27-32), 2-1 | County Stadium (0-1) | 33-31 | Lost 7 |
| » W: Jack Fisher (2-3) L: Steve Hargan (4-7) S: Bob Locker (6) | Third | 8½ out |
| Tuesday, June 18 |
| » Defeated White Sox (27-33), 4-1 | Comiskey Park I (2-0) | 34-31 | |
| » W: Sam McDowell (7-5) L: Gary Peters (3-7) S: Stan Williams (2) | Third | 8½ out |
| Wednesday, June 19 |
| » Defeated White Sox (27-34), 3-1 | Comiskey Park I (3-0) | 35-31 | Won 2 |
| » W: Luis Tiant (10-5) L: Bob Locker (3-4) | Second | 7½ out |
| Thursday, June 20 |
| » Lost to White Sox (28-34), 8-4 | Comiskey Park I (3-1) | 35-32 | |
| » W: Tommy John (6-0) L: Mike Paul (0-3) S: Wilbur Wood (9) | Fourth | 8½ out |
| Friday, June 21 |
| » Defeated Tigers (43-24), 4-3 | Cleveland Stadium (19-14) | 36-32 | |
| » W: Eddie Fisher (2-2) L: Pat Dobson (2-1) | Third | 7½ out |
| Saturday, June 22 |
| » Defeated Tigers (43-25), 2-0 | Cleveland Stadium (20-14) | 37-32 | Won 2 |
| » W: Steve Hargan (5-7) L: Earl Wilson (5-5) S: Stan Williams (3) | Second | 6½ out |
| Sunday, June 23 |
| » Defeated Tigers (43-26), 3-0 | Cleveland Stadium (21-14) | 38-32 | Won 3 |
| » W: Luis Tiant (11-5) L: John Hiller (5-2) | Second | 6½ out |
| » Lost to Tigers (44-26), 4-1 | Cleveland Stadium (21-15) | 38-33 | |
| » W: Joe Sparma (6-7) L: Sam McDowell (7-6) S: Pat Dobson (3) | Second | 6½ out |
| Monday, June 24 |
| » Lost to Tigers (45-26), 14-3 | Cleveland Stadium (21-16) | 38-34 | Lost 2 |
| » W: Denny McLain (13-2) L: Mike Paul (0-4) | Second | 7½ out |
| Tuesday, June 25 |
| » Defeated Senators (25-41), 6-1 | Robert F. Kennedy Stadium (2-3) | 39-34 | |
| » W: Sonny Siebert (7-5) L: Joe Coleman (4-8) S: Stan Williams (4) | Second | 7½ out |
| Wednesday, June 26 |
| » Lost to Senators (26-41), 8-2 | Robert F. Kennedy Stadium (2-4) | 39-35 | |
| » W: Camilo Pascual (7-4) L: Steve Hargan (5-8) | Third | 8 out |
| Thursday, June 27 |
| » Lost to Red Sox (34-35), 9-3 | Fenway Park (1-3) | 39-36 | Lost 2 |
| » W: Jose Santiago (9-4) L: Sam McDowell (7-7) S: Sparky Lyle (4) | Fourth | 8½ out |
| Saturday, June 29 |
| » Defeated Red Sox (34-36), 8-1 | Fenway Park (2-3) | 40-36 | |
| » W: Luis Tiant (12-5) L: Gary Bell (6-3) | Second | 8½ out |
| » Defeated Red Sox (34-37), 4-1 | Fenway Park (3-3) | 41-36 | Won 2 |
| » W: Sonny Siebert (8-5) L: Ray Culp (4-4) | Second | 8½ out |
| Sunday, June 30 |
| » Defeated Red Sox (34-38), 7-5 | Fenway Park (4-3) | 42-36 | Won 3 |
| » W: Stan Williams (6-4) L: Jerry Stephenson (1-6) | Second | 7½ out |
| Monday, July 1 |
| » Defeated Twins (38-36), 4-1 | Cleveland Stadium (22-16) | 43-36 | Won 4 |
| » W: Sam McDowell (8-7) L: Dave Boswell (7-7) S: Stan Williams (5) | Second | 7½ out |
| Tuesday, July 2 |
| » Lost to Twins (39-36), 6-0 | Cleveland Stadium (22-17) | 43-37 | |
| » W: Jim Kaat (6-4) L: Steve Hargan (5-9) | Second | 8½ out |
| Wednesday, July 3 |
| » Defeated Twins (39-37), 1-0 | Cleveland Stadium (23-17) | 44-37 | |
| » W: Luis Tiant (13-5) L: Jim Merritt (5-8) | Second | 8½ out |
| Thursday, July 4 |
| » Defeated Twins (39-38), 6-3 | Cleveland Stadium (24-17) | 45-37 | Won 2 |
| » W: Vicente Romo (1-0) L: Dean Chance (7-9) S: Stan Williams (6) | Second | 8½ out |
| Friday, July 5 |
| » Defeated Angels (37-42), 5-1 | Cleveland Stadium (25-17) | 46-37 | Won 3 |
| » W: Sonny Siebert (9-5) L: Rickey Clark (1-9) S: Stan Williams (7) | Second | 8½ out |
| Saturday, July 6 |
| » Lost to Angels (38-42), 2-0 | Cleveland Stadium (25-18) | 46-38 | |
| » W: George Brunet (7-9) L: Sam McDowell (8-8) | Second | 8½ out |
| Sunday, July 7 |
| » Defeated Angels (38-43), 8-3 | Cleveland Stadium (26-18) | 47-38 | |
| » W: Luis Tiant (14-5) L: Jim McGlothlin (6-6) S: Vicente Romo (1) | Second | 9½ out |
| » Lost to Angels (39-43), 9-7 | Cleveland Stadium (26-19) | 47-39 | |
| » W: Sammy Ellis (6-6) L: Steve Hargan (5-10) S: Tom Burgmeier (3) | Second | 9½ out |
| Monday, July 8 |
| Future Indian Garland Kiser is born in Charlotte, NC. |
| Thursday, July 11 |
| » Lost to Athletics (40-43), 4-3 | Oakland-Alameda County Stadium (1-3) | 47-40 | Lost 2 |
| » W: Chuck Dobson (7-8) L: Mike Paul (0-5) | Third | 9½ out |
| Friday, July 12 |
| » Defeated Athletics (40-44), 6-3 | Oakland-Alameda County Stadium (2-3) | 48-40 | |
| » W: Sam McDowell (9-8) L: Catfish Hunter (6-8) S: Vicente Romo (2) | Third | 9½ out |
| Saturday, July 13 |
| » Lost to Athletics (41-44), 4-3 | Oakland-Alameda County Stadium (2-4) | 48-41 | |
| » W: Lew Krausse (6-7) L: Vicente Romo (1-1) S: Jack Aker (7) | Third | 9½ out |
| Sunday, July 14 |
| » Defeated Twins (41-44), 6-3 | Metropolitan Stadium (3-2) | 49-41 | |
| » W: Luis Tiant (15-5) L: Jim Merritt (5-10) S: Stan Williams (8) | Third | 8½ out |
| Monday, July 15 |
| » Defeated Twins (41-45), 4-2 | Metropolitan Stadium (4-2) | 50-41 | Won 2 |
| » W: Sonny Siebert (10-5) L: Jim Perry (6-6) S: Stan Williams (9) | Third | 7½ out |
| Tuesday, July 16 |
| » Defeated Angels (42-46), 2-1 | Anaheim Stadium (3-2) | 51-41 | Won 3 |
| » W: Stan Williams (7-4) L: Bobby Locke (1-1) | Third | 7½ out |
| Wednesday, July 17 |
| » Defeated Angels (42-47), 4-2 | Anaheim Stadium (4-2) | 52-41 | Won 4 |
| » W: Steve Hargan (6-10) L: Rickey Clark (1-10) S: Vicente Romo (3) | Third | 6½ out |
| Saturday, July 20 |
| » Defeated Yankees (42-47), 3-0 | Yankee Stadium (3-1) | 53-41 | Won 5 |
| » W: Luis Tiant (16-5) L: Fritz Peterson (6-5) | Second | 6½ out |
| Sunday, July 21 |
| » Defeated Yankees (42-48), 4-1 | Yankee Stadium (4-1) | 54-41 | Won 6 |
| » W: Sam McDowell (10-8) L: Mel Stottlemyre (12-7) S: Vicente Romo (4) | Third | 5½ out |
| » Lost to Yankees (43-48), 8-4 | Yankee Stadium (4-2) | 54-42 | |
| » W: Steve Barber (4-3) L: Steve Hargan (6-11) S: Lindy McDaniel (2) | Third | 5½ out |
| Monday, July 22 |
| » Defeated Orioles (52-41), 7-3 | Memorial Stadium (5-0) | 55-42 | |
| » W: Sonny Siebert (11-5) L: Mike Adamson (0-1) S: Eddie Fisher (2) | Second | 5 out |
| Tuesday, July 23 |
| » Lost to Orioles (53-41), 8-6 | Memorial Stadium (5-1) | 55-43 | |
| » W: John Morris (1-0) L: Stan Williams (7-5) S: Moe Drabowsky (7) | Third | 6 out |
| Wednesday, July 24 |
| » Lost to Orioles (54-41), 1-0 | Memorial Stadium (5-2) | 55-44 | Lost 2 |
| » W: Dave McNally (12-8) L: Luis Tiant (16-6) | Third | 6 out |
| Friday, July 26 |
| » Lost to Yankees (45-49), 5-0 | Cleveland Stadium (26-20) | 55-45 | Lost 3 |
| » W: Mel Stottlemyre (13-7) L: Sam McDowell (10-9) | Third | 7½ out |
| Future Indian Mike Mohler is born in Dayton, OH. |
| Saturday, July 27 |
| » Lost to Yankees (46-49), 6-3 | Cleveland Stadium (26-21) | 55-46 | Lost 4 |
| » W: Steve Barber (5-3) L: Sonny Siebert (11-6) S: Lindy McDaniel (3) | Third | 8½ out |
| Sunday, July 28 |
| » Defeated Yankees (46-50), 3-2 | Cleveland Stadium (27-21) | 56-46 | |
| » W: Luis Tiant (17-6) L: Fritz Peterson (6-6) | Third | 7 out |
| » Defeated Yankees (46-51), 4-1 | Cleveland Stadium (28-21) | 57-46 | Won 2 |
| » W: Stan Williams (8-5) L: Stan Bahnsen (9-7) | Third | 7 out |
| Monday, July 29 |
| » Lost to Senators (36-62), 4-2 | Cleveland Stadium (28-22) | 57-47 | |
| » W: Jim Hannan (5-2) L: Vicente Romo (1-2) | Third | 7 out |
| Tuesday, July 30 |
| » Defeated Senators (36-63), 10-1 | Cleveland Stadium (29-22) | 58-47 | |
| » W: Sam McDowell (11-9) L: Bruce Howard (1-6) S: Mike Paul (3) | Third | 7 out |
| Wednesday, July 31 |
| » Lost to Orioles (57-45), 4-2 | Cleveland Stadium (29-23) | 58-48 | |
| » W: Tom Phoebus (11-10) L: Sonny Siebert (11-7) S: Gene Brabender (2) | Third | 8 out |
| Thursday, August 1 |
| » Lost to Orioles (58-45), 5-1 | Cleveland Stadium (29-24) | 58-49 | Lost 2 |
| » W: Dave McNally (14-8) L: Luis Tiant (17-7) | Third | 8 out |
| Friday, August 2 |
| » Lost to Athletics (54-51), 5-1 | Cleveland Stadium (29-25) | 58-50 | Lost 3 |
| » W: Jim Nash (9-6) L: Stan Williams (8-6) S: Lew Krausse (1) | Third | 9 out |
| Saturday, August 3 |
| » Defeated Athletics (54-52), 4-1 | Cleveland Stadium (30-25) | 59-50 | |
| » W: Sam McDowell (12-9) L: Blue Moon Odom (9-8) S: Vicente Romo (5) | Third | 8 out |
| Sunday, August 4 |
| » Lost to Athletics (55-52), 5-0 | Cleveland Stadium (30-26) | 59-51 | |
| » W: Chuck Dobson (9-11) L: Sonny Siebert (11-8) S: Lew Krausse (2) | Third | 8½ out |
| » Defeated Athletics (55-53), 7-4 | Cleveland Stadium (31-26) | 60-51 | |
| » W: Steve Hargan (7-11) L: Catfish Hunter (9-9) S: Vicente Romo (6) | Third | 8½ out |
| Tuesday, August 6 |
| » Lost to Tigers (68-41), 2-1 | Tiger Stadium (1-5) | 60-52 | |
| » W: John Wyatt (2-4) L: Mike Paul (0-6) | Third | 9½ out |
| » Game at Tiger Stadium interrupted in the 9th inning with the score of Tigers 5, Indians 2. Completed on August 07. |
| Wednesday, August 7 |
| » Lost to Tigers (69-41), 6-1 | Tiger Stadium (1-6) | 60-53 | Lost 2 |
| » W: Earl Wilson (10-9) L: Sam McDowell (12-10) S: Daryl Patterson (6) | Fourth | 11½ out |
| » Lost to Tigers (70-41), 5-2 | Tiger Stadium (1-7) | 60-54 | Lost 3 |
| » W: Mickey Lolich (8-7) L: Stan Williams (8-7) S: John Wyatt (1) | Fourth | 11½ out |
| Thursday, August 8 |
| » Lost to Tigers (71-41), 13-1 | Tiger Stadium (1-8) | 60-55 | Lost 4 |
| » W: Denny McLain (23-3) L: Sonny Siebert (11-9) | Fourth | 12½ out |
| Friday, August 9 |
| » Lost to White Sox (48-62), 1-0 | Comiskey Park I (3-2) | 60-56 | Lost 5 |
| » W: Tommy John (8-5) L: Steve Hargan (7-12) S: Hoyt Wilhelm (9) | Fourth | 12½ out |
| Saturday, August 10 |
| » Defeated White Sox (48-63), 3-2 | Comiskey Park I (4-2) | 61-56 | |
| » W: Luis Tiant (18-7) L: Wilbur Wood (8-6) | Fourth | 12½ out |
| Sunday, August 11 |
| » Defeated White Sox (48-64), 6-1 | Comiskey Park I (5-2) | 62-56 | Won 2 |
| » W: Stan Williams (9-7) L: Bob Priddy (3-7) | Fourth | 12½ out |
| » Defeated White Sox (48-65), 2-1 | Comiskey Park I (6-2) | 63-56 | Won 3 |
| » W: Eddie Fisher (3-2) L: Danny Lazar (0-1) | Fourth | 12½ out |
| Monday, August 12 |
| » Lost to Tigers (75-42), 6-3 | Cleveland Stadium (31-27) | 63-57 | |
| » W: Denny McLain (24-3) L: Vicente Romo (1-3) | Fourth | 13½ out |
| Tuesday, August 13 |
| » Defeated Tigers (75-43), 1-0 | Cleveland Stadium (32-27) | 64-57 | |
| » W: Sonny Siebert (12-9) L: Pat Dobson (3-5) | Fourth | 12½ out |
| Wednesday, August 14 |
| » Lost to Tigers (76-43), 3-0 | Cleveland Stadium (32-28) | 64-58 | |
| » W: Mickey Lolich (11-7) L: Luis Tiant (18-8) | Fourth | 13½ out |
| » Major-league debuts: Horacio Pina (Indians) |
| Friday, August 16 |
| » Defeated White Sox (49-70), 4-3 | Cleveland Stadium (33-28) | 65-58 | |
| » W: Eddie Fisher (4-2) L: Hoyt Wilhelm (2-4) | Fourth | 13½ out |
| Saturday, August 17 |
| » Defeated White Sox (49-71), 6-5 | Cleveland Stadium (34-28) | 66-58 | Won 2 |
| » W: Stan Williams (10-7) L: Bob Priddy (3-9) S: Horacio Pina (1) | Fourth | 13½ out |
| Sunday, August 18 |
| » Lost to White Sox (50-71), 4-2 | Cleveland Stadium (34-29) | 66-59 | |
| » W: Tommy John (10-5) L: Sonny Siebert (12-10) | Fourth | 14 out |
| » Lost to White Sox (51-71), 8-1 | Cleveland Stadium (34-30) | 66-60 | Lost 2 |
| » W: Joe Horlen (9-11) L: Steve Hargan (7-13) | Fourth | 14 out |
| Monday, August 19 |
| » Lost to Red Sox (68-57), 3-0 | Cleveland Stadium (34-31) | 66-61 | Lost 3 |
| » W: Dave Morehead (1-2) L: Luis Tiant (18-9) | Fourth | 14½ out |
| Tuesday, August 20 |
| » Defeated Red Sox (68-58), 2-1 | Cleveland Stadium (35-31) | 67-61 | |
| » W: Sam McDowell (13-10) L: Gary Bell (10-9) | Fourth | 14 out |
| Wednesday, August 21 |
| » Defeated Red Sox (68-59), 8-2 | Cleveland Stadium (36-31) | 68-61 | Won 2 |
| » W: Horacio Pina (1-0) L: Jim Lonborg (3-5) S: Vicente Romo (7) | Fourth | 14 out |
| Thursday, August 22 |
| » Defeated Red Sox (68-60), 3-1 | Cleveland Stadium (37-31) | 69-61 | Won 3 |
| » W: Stan Williams (11-7) L: Ray Culp (9-5) S: Vicente Romo (8) | Third | 14 out |
| Friday, August 23 |
| » Defeated Senators (47-77), 6-2 | Robert F. Kennedy Stadium (3-4) | 70-61 | Won 4 |
| » W: Mike Paul (1-6) L: Camilo Pascual (11-8) S: Eddie Fisher (3) | Fourth | 13 out |
| Saturday, August 24 |
| » Defeated Senators (47-78), 2-1 | Robert F. Kennedy Stadium (4-4) | 71-61 | Won 5 |
| » W: Steve Hargan (8-13) L: Phil Ortega (5-12) | Third | 12 out |
| Sunday, August 25 |
| » Lost to Senators (48-78), 10-9 | Robert F. Kennedy Stadium (4-5) | 71-62 | |
| » W: Bob Humphreys (4-5) L: Steve Hargan (8-14) S: Dennis Higgins (8) | Third | 11½ out |
| Monday, August 26 |
| » Lost to Red Sox (70-62), 3-0 | Fenway Park (4-4) | 71-63 | Lost 2 |
| » W: Jim Lonborg (4-5) L: Horacio Pina (1-1) | Third | 12½ out |
| Tuesday, August 27 |
| » Lost to Red Sox (71-62), 7-1 | Fenway Park (4-5) | 71-64 | Lost 3 |
| » W: Ray Culp (10-5) L: Stan Williams (11-8) | Fourth | 12½ out |
| Wednesday, August 28 |
| » Defeated Twins (63-71), 3-2 | Cleveland Stadium (38-31) | 72-64 | |
| » W: Vicente Romo (2-3) L: Dave Boswell (9-11) | Fourth | 12½ out |
| Thursday, August 29 |
| » Lost to Twins (64-71), 3-2 | Cleveland Stadium (38-32) | 72-65 | |
| » W: Jim Kaat (11-10) L: Mike Paul (1-7) | Fourth | 13½ out |
| Friday, August 30 |
| » Lost to Yankees (66-67), 1-0 | Cleveland Stadium (38-33) | 72-66 | Lost 2 |
| » W: Fritz Peterson (8-9) L: Sam McDowell (13-11) | Fourth | 14 out |
| » Defeated Yankees (66-68), 3-2 | Cleveland Stadium (39-33) | 73-66 | |
| » W: Vicente Romo (3-3) L: Dooley Womack (3-7) | Fourth | 14 out |
| Saturday, August 31 |
| » Lost to Yankees (67-68), 3-1 | Cleveland Stadium (39-34) | 73-67 | |
| » W: Stan Bahnsen (14-9) L: Stan Williams (11-9) | Fourth | 14 out |
| Former Indian Jay Kirke dies in New Orleans, LA at the age of 81. |
| Sunday, September 1 |
| » Lost to Yankees (68-68), 5-1 | Cleveland Stadium (39-35) | 73-68 | Lost 2 |
| » W: Joe Verbanic (5-5) L: Steve Hargan (8-15) | Fourth | 15 out |
| Monday, September 2 |
| » Defeated Angels (61-79), 4-2 | Anaheim Stadium (5-2) | 74-68 | |
| » W: Mike Paul (2-7) L: George Brunet (13-14) S: Eddie Fisher (4) | Fourth | 14½ out |
| Tuesday, September 3 |
| » Defeated Angels (61-80), 7-2 | Anaheim Stadium (6-2) | 75-68 | Won 2 |
| » W: Sam McDowell (14-11) L: Jim McGlothlin (10-13) S: Vicente Romo (9) | Fourth | 14½ out |
| Wednesday, September 4 |
| » Defeated Angels (61-81), 9-5 | Anaheim Stadium (7-2) | 76-68 | Won 3 |
| » W: Luis Tiant (19-9) L: Bill Harrelson (1-5) S: Vicente Romo (10) | Fourth | 14½ out |
| Friday, September 6 |
| » Lost to Athletics (72-71), 7-0 | Oakland-Alameda County Stadium (2-5) | 76-69 | |
| » W: Blue Moon Odom (14-9) L: Stan Williams (11-10) | Fourth | 15½ out |
| Saturday, September 7 |
| » Lost to Athletics (73-71), 2-0 | Oakland-Alameda County Stadium (2-6) | 76-70 | Lost 2 |
| » W: Jim Nash (12-11) L: Sam McDowell (14-12) | Fourth | 15½ out |
| Sunday, September 8 |
| » Lost to Athletics (74-71), 10-2 | Oakland-Alameda County Stadium (2-7) | 76-71 | Lost 3 |
| » W: Catfish Hunter (12-12) L: Mike Paul (2-8) | Fourth | 15½ out |
| Monday, September 9 |
| » Defeated Twins (69-76), 6-1 | Metropolitan Stadium (5-2) | 77-71 | |
| » W: Luis Tiant (20-9) L: Jim Merritt (10-16) | Fourth | 15½ out |
| » Major-league debuts: Eddie Leon (Indians) |
| Tuesday, September 10 |
| » Defeated Twins (69-77), 6-2 | Metropolitan Stadium (6-2) | 78-71 | Won 2 |
| » W: Stan Williams (12-10) L: Jim Kaat (12-12) | Fourth | 15½ out |
| Wednesday, September 11 |
| » Defeated Twins (69-78), 1-0 | Metropolitan Stadium (7-2) | 79-71 | Won 3 |
| » W: Vicente Romo (4-3) L: Ron Perranoski (7-7) S: Horacio Pina (2) | Fourth | 15½ out |
| Thursday, September 12 |
| Former Indian Don Rudolph dies in Granada Hills, CA at the age of 38. |
| Friday, September 13 |
| » Defeated Orioles (85-64), 10-2 | Cleveland Stadium (40-35) | 80-71 | Won 4 |
| » W: Mike Paul (3-8) L: Gene Brabender (6-7) | Fourth | 15½ out |
| Saturday, September 14 |
| » Lost to Orioles (86-64), 5-3 | Cleveland Stadium (40-36) | 80-72 | |
| » W: Roger Nelson (3-1) L: Steve Bailey (0-1) S: Eddie Watt (10) | Fourth | 16½ out |
| Sunday, September 15 |
| » Defeated Orioles (86-65), 2-0 | Cleveland Stadium (41-36) | 81-72 | |
| » W: Stan Williams (13-10) L: Jim Hardin (18-11) | Fourth | 16½ out |
| Tuesday, September 17 |
| » Lost to Senators (59-93), 4-2 | Cleveland Stadium (41-37) | 81-73 | |
| » W: Barry Moore (3-6) L: Sam McDowell (14-13) S: Bob Humphreys (2) | Third | 18 out |
| Wednesday, September 18 |
| » Major-league debuts: Fred Beene and Bobby Floyd (Orioles) |
| Saturday, September 21 |
| » Defeated Angels (66-89), 3-2 | Cleveland Stadium (42-37) | 82-73 | |
| » W: Mike Paul (4-8) L: George Brunet (13-17) S: Vicente Romo (11) | Fourth | 19 out |
| Sunday, September 22 |
| » Defeated Angels (66-90), 2-1 | Cleveland Stadium (43-37) | 83-73 | Won 2 |
| » W: Vicente Romo (5-3) L: Steve Kealey (0-1) | Fourth | 18 out |
| Tuesday, September 24 |
| » Lost to Yankees (81-76), 5-1 | Yankee Stadium (4-3) | 83-74 | |
| » W: Mel Stottlemyre (21-12) L: Sam McDowell (14-14) | Third | 18 out |
| » Defeated Yankees (81-77), 5-2 | Yankee Stadium (5-3) | 84-74 | |
| » W: Mike Paul (5-8) L: Fritz Peterson (12-11) S: Vicente Romo (12) | Third | 18 out |
| Wednesday, September 25 |
| » Defeated Yankees (81-78), 3-0 | Yankee Stadium (6-3) | 85-74 | Won 2 |
| » W: Luis Tiant (21-9) L: Stan Bahnsen (16-12) | Third | 18 out |
| Future Indian Reggie Jefferson is born in Tallahassee, FL. Former Indian Ken Holloway dies in Thomasville, GA at the age of 72. |
| Thursday, September 26 |
| » Lost to Orioles (91-70), 7-1 | Memorial Stadium (5-3) | 85-75 | |
| » W: Dave McNally (22-10) L: Stan Williams (13-11) | Fourth | 18½ out |
| Friday, September 27 |
| » Defeated Orioles (91-71), 2-0 | Memorial Stadium (6-3) | 86-75 | |
| » W: Sam McDowell (15-14) L: Roger Nelson (4-3) | Fourth | 17½ out |
| Thursday, October 31 |
| Future Indian Eddie Taubensee is born in Beeville, TX. |
| Monday, November 4 |
| Future Indian Carlos Baerga is born in Santurce, P.R. |
| Wednesday, November 6 |
| Future Indian Chad Curtis is born in Marion, IN. |
| Saturday, November 16 |
| Future Indian Chris Haney is born in Baltimore, MD. |
| Sunday, December 8 |
| Former Indian Benn Karr dies in Memphis, TN at the age of 76. |
Game information provided by Retrosheet (www.retrosheet.org) |