| Monday, January 29 |
| Future Cub Kevin Roberson is born in Decatur, IL. |
| Sunday, February 11 |
| Future Cub Dave Swartzbaugh is born in Middletown, OH. |
| Tuesday, February 13 |
| Future Cub Matt Mieske is born in Midland, MI. |
| Friday, February 23 |
| Former Cub Hank Schreiber dies in Indianapolis, IN at the age of 77. |
| Wednesday, March 20 |
| Former Cub Clyde Shoun dies in Mountain Home, TN at the age of 57. |
| Tuesday, March 26 |
| Future Cub Jose Vizcaino is born in San Cristobal, D.R. |
| Sunday, March 31 |
| Former Cub Grover Lowdermilk dies in Odin, IL at the age of 84. |
| Wednesday, April 10 |
| » Lost to Reds (1-0), 9-4 | Crosley Field (0-1) | 0-1 | |
| » Starters: Joe Niekro vs Milt Pappas | Second | 1 out |
| » Major-league debuts: Jose Arcia (Cubs) |
| Thursday, April 11 |
| » Defeated Reds (1-1), 10-3 | Crosley Field (1-1) | 1-1 | |
| » Starters: Fergie Jenkins vs Mel Queen | Second | 1 out |
| Saturday, April 13 |
| » Lost to Cardinals (3-0), 8-5 | Wrigley Field (0-1) | 1-2 | |
| » Starters: Steve Carlton vs Rich Nye | Fifth | 2½ out |
| Sunday, April 14 |
| » Defeated Cardinals (3-1), 7-6 | Wrigley Field (1-1) | 2-2 | |
| » Starters: Dick Hughes vs Joe Niekro | Fourth | 1½ out |
| Tuesday, April 16 |
| » Lost to Reds (2-3), 9-8 | Wrigley Field (1-2) | 2-3 | |
| » Starters: Gerry Arrigo vs Fergie Jenkins | Fourth | 2½ out |
| Wednesday, April 17 |
| » Lost to Braves (3-4), 2-0 | Atlanta-Fulton County Stadium (0-1) | 2-4 | Lost 2 |
| » Starters: Bill Hands vs Phil Niekro | Fifth | 2½ out |
| Thursday, April 18 |
| » Lost to Braves (4-4), 5-3 | Atlanta-Fulton County Stadium (0-2) | 2-5 | Lost 3 |
| » Starters: Joe Niekro vs Ken Johnson | Seventh | 3 out |
| Friday, April 19 |
| » Lost to Cardinals (6-3), 9-2 | Busch Stadium II (0-1) | 2-6 | Lost 4 |
| » Starters: Rich Nye vs Mike Torrez | Eighth | 3½ out |
| » Major-league debuts: Bill Plummer (Cubs) |
| Saturday, April 20 |
| » Defeated Cardinals (6-4), 5-1 | Busch Stadium II (1-1) | 3-6 | |
| » Starters: Fergie Jenkins vs Bob Gibson | Eighth | 3 out |
| Sunday, April 21 |
| » Lost to Cardinals (7-4), 9-2 | Busch Stadium II (1-2) | 3-7 | |
| » Starters: Ken Holtzman vs Nelson Briles | Eighth | 3½ out |
| Tuesday, April 23 |
| » Defeated Braves (6-6), 10-4 | Wrigley Field (2-2) | 4-7 | |
| » Starters: Phil Niekro vs Joe Niekro | Eighth | 3½ out |
| Thursday, April 25 |
| » Defeated Braves (6-7), 5-2 | Wrigley Field (3-2) | 5-7 | Won 2 |
| » Starters: Ken Johnson vs Fergie Jenkins | Seventh | 3½ out |
| Friday, April 26 |
| » Defeated Astros (5-7), 3-2 | Wrigley Field (4-2) | 6-7 | Won 3 |
| » Starters: Larry Dierker vs Bill Hands | Sixth | 3½ out |
| Saturday, April 27 |
| » Lost to Astros (6-7), 8-1 | Wrigley Field (4-3) | 6-8 | |
| » Starters: Dave Giusti vs Rich Nye | Seventh | 4½ out |
| Sunday, April 28 |
| » Defeated Astros (6-8), 8-4 | Wrigley Field (5-3) | 7-8 | |
| » Starters: Don Wilson vs Joe Niekro | Third | 4 out |
| » Defeated Astros (6-9), 5-2 | Wrigley Field (6-3) | 8-8 | Won 2 |
| » Starters: Denny Lemaster vs Ken Holtzman | Third | 4 out |
| Monday, April 29 |
| » Lost to Pirates (7-8), 7-4 | Forbes Field (0-1) | 8-9 | |
| » Starters: Fergie Jenkins vs Steve Blass | Fifth | 4 out |
| Tuesday, April 30 |
| » Lost to Pirates (8-8), 4-3 | Forbes Field (0-2) | 8-10 | Lost 2 |
| » Starters: Bill Hands vs Bob Veale | Sixth | 5 out |
| Wednesday, May 1 |
| » Lost to Pirates (9-8), 4-0 | Forbes Field (0-3) | 8-11 | Lost 3 |
| » Starters: Rich Nye vs Al McBean | Sixth | 6 out |
| Thursday, May 2 |
| » Defeated Pirates (9-9), 1-0 | Forbes Field (1-3) | 9-11 | |
| » Starters: Joe Niekro vs Jim Bunning | Sixth | 5 out |
| Saturday, May 4 |
| » Lost to Mets (9-10), 7-3 | Shea Stadium (0-1) | 9-12 | |
| » Starters: Ken Holtzman vs Dick Selma | Seventh | 5½ out |
| Sunday, May 5 |
| » Defeated Mets (9-11), 3-2 | Shea Stadium (1-1) | 10-12 | |
| » Starters: Fergie Jenkins vs Jerry Koosman | Fourth | 4 out |
| » Defeated Mets (9-12), 1-0 | Shea Stadium (2-1) | 11-12 | Won 2 |
| » Starters: Bill Hands vs Don Cardwell | Fourth | 4 out |
| Tuesday, May 7 |
| » Lost to Dodgers (12-12), 2-1 | Wrigley Field (6-4) | 11-13 | |
| » Starters: Claude Osteen vs Rich Nye | Sixth | 4½ out |
| Wednesday, May 8 |
| » Defeated Dodgers (12-13), 7-6 | Wrigley Field (7-4) | 12-13 | |
| » Starters: Don Sutton vs Joe Niekro | Fourth | 4½ out |
| Thursday, May 9 |
| » Lost to Dodgers (13-13), 6-0 | Wrigley Field (7-5) | 12-14 | |
| » Starters: Bill Singer vs Ken Holtzman | Sixth | 5 out |
| Friday, May 10 |
| » Lost to Mets (11-14), 5-1 | Wrigley Field (7-6) | 12-15 | Lost 2 |
| » Starters: Jerry Koosman vs Fergie Jenkins | Seventh | 5½ out |
| Saturday, May 11 |
| » Defeated Mets (11-15), 3-1 | Wrigley Field (8-6) | 13-15 | |
| » Starters: Tom Seaver vs Bill Hands | Sixth | 5½ out |
| Sunday, May 12 |
| » Defeated Mets (11-16), 4-3 | Wrigley Field (9-6) | 14-15 | Won 2 |
| » Starters: Don Cardwell vs Rich Nye | Seventh | 5 out |
| » Lost to Mets (12-16), 10-0 | Wrigley Field (9-7) | 14-16 | |
| » Starters: Dick Selma vs Joe Niekro | Seventh | 5 out |
| Future Cub Mark Clark is born in Bath, IL. |
| Monday, May 13 |
| » Defeated Dodgers (14-16), 5-1 | Dodger Stadium (1-0) | 15-16 | |
| » Starters: Ken Holtzman vs Bill Singer | Fifth | 5 out |
| Tuesday, May 14 |
| » Lost to Dodgers (15-16), 1-0 | Dodger Stadium (1-1) | 15-17 | |
| » Starters: Fergie Jenkins vs Don Drysdale | Sixth | 5½ out |
| Wednesday, May 15 |
| » Defeated Dodgers (15-17), 5-3 | Dodger Stadium (2-1) | 16-17 | |
| » Starters: Bill Hands vs Mudcat Grant | Fourth | 5½ out |
| Thursday, May 16 |
| » Defeated Dodgers (15-18), 1-0 | Dodger Stadium (3-1) | 17-17 | Won 2 |
| » Starters: Rich Nye vs Don Sutton | Fifth | 4½ out |
| Friday, May 17 |
| » Lost to Giants (19-14), 2-0 | Candlestick Park (0-1) | 17-18 | |
| » Starters: Joe Niekro vs Ray Sadecki | Fourth | 4½ out |
| Saturday, May 18 |
| » Defeated Giants (19-15), 10-7 | Candlestick Park (1-1) | 18-18 | |
| » Starters: Ken Holtzman vs Mike McCormick | Sixth | 3½ out |
| Sunday, May 19 |
| » Lost to Giants (20-15), 1-0 | Candlestick Park (1-2) | 18-19 | |
| » Starters: Fergie Jenkins vs Gaylord Perry | Fifth | 3 out |
| » Defeated Giants (20-16), 6-3 | Candlestick Park (2-2) | 19-19 | |
| » Starters: Bill Hands vs Bobby Bolin | Fifth | 3 out |
| Tuesday, May 21 |
| » Defeated Phillies (17-17), 6-5 | Wrigley Field (10-7) | 20-19 | Won 2 |
| » Starters: Rick Wise vs Rich Nye | Fourth | 2½ out |
| Wednesday, May 22 |
| » Lost to Pirates (16-20), 13-6 | Wrigley Field (10-8) | 20-20 | |
| » Starters: Jim Bunning vs Joe Niekro | Sixth | 2½ out |
| Friday, May 24 |
| » Lost to Giants (24-17), 4-2 | Wrigley Field (10-9) | 20-21 | Lost 2 |
| » Starters: Juan Marichal vs Ken Holtzman | Sixth | 4 out |
| Saturday, May 25 |
| » Defeated Giants (24-18), 3-0 | Wrigley Field (11-9) | 21-21 | |
| » Starters: Ray Sadecki vs Fergie Jenkins | Fifth | 3 out |
| Sunday, May 26 |
| » Defeated Giants (24-19), 4-2 | Wrigley Field (12-9) | 22-21 | Won 2 |
| » Starters: Mike McCormick vs Bill Hands | Fifth | 2 out |
| Wednesday, May 29 |
| » Defeated Phillies (20-19), 9-2 | Shibe Park (1-0) | 23-21 | Won 3 |
| » Starters: Ken Holtzman vs Chris Short | Fifth | 3 out |
| » Lost to Phillies (21-19), 8-3 | Shibe Park (1-1) | 23-22 | |
| » Starters: Rich Nye vs Rick Wise | Fifth | 3 out |
| Friday, May 31 |
| » Lost to Astros (21-24), 3-1 | Astrodome (0-1) | 23-23 | Lost 2 |
| » Starters: Fergie Jenkins vs Larry Dierker | Sixth | 2½ out |
| Saturday, June 1 |
| » Defeated Astros (21-25), 3-1 | Astrodome (1-1) | 24-23 | |
| » Starters: Bill Hands vs Don Wilson | Fourth | 1½ out |
| Sunday, June 2 |
| » Defeated Astros (21-26), 3-2 | Astrodome (2-1) | 25-23 | Won 2 |
| » Starters: Ken Holtzman vs Dave Giusti | Fourth | 2 out |
| Tuesday, June 4 |
| » Lost to Mets (21-27), 5-0 | Wrigley Field (12-10) | 25-24 | |
| » Starters: Jerry Koosman vs Fergie Jenkins | Fifth | 3½ out |
| Wednesday, June 5 |
| » Lost to Mets (22-27), 4-2 | Wrigley Field (12-11) | 25-25 | Lost 2 |
| » Starters: Tom Seaver vs Rich Nye | Seventh | 4½ out |
| Thursday, June 6 |
| » Lost to Mets (23-27), 5-3 | Wrigley Field (12-12) | 25-26 | Lost 3 |
| » Starters: Dick Selma vs Ken Holtzman | Seventh | 5½ out |
| » Major-league debuts: Frank Reberger (Cubs) |
| Friday, June 7 |
| » Lost to Braves (28-24), 7-6 | Wrigley Field (12-13) | 25-27 | Lost 4 |
| » Starters: Pat Jarvis vs Joe Niekro | Seventh | 5½ out |
| Sunday, June 9 |
| » Lost to Braves (29-24), 4-0 | Wrigley Field (12-14) | 25-28 | Lost 5 |
| » Starters: Ken Johnson vs Fergie Jenkins | Seventh | 6 out |
| » Defeated Braves (29-25), 6-5 | Wrigley Field (13-14) | 26-28 | |
| » Starters: Ron Reed vs Bill Hands | Seventh | 6 out |
| Monday, June 10 |
| » Defeated Reds (27-27), 4-3 | Wrigley Field (14-14) | 27-28 | Won 2 |
| » Starters: Gary Nolan vs Ken Holtzman | Seventh | 6 out |
| Tuesday, June 11 |
| » Lost to Reds (28-27), 9-7 | Wrigley Field (14-15) | 27-29 | |
| » Starters: George Culver vs Joe Niekro | Seventh | 7 out |
| Wednesday, June 12 |
| » Defeated Reds (28-28), 4-1 | Wrigley Field (15-15) | 28-29 | |
| » Starters: Jim Maloney vs Fergie Jenkins | Sixth | 6 out |
| Thursday, June 13 |
| » Defeated Reds (28-29), 8-4 | Wrigley Field (16-15) | 29-29 | Won 2 |
| » Starters: Tony Cloninger vs Frank Reberger | Sixth | 6 out |
| Friday, June 14 |
| » Defeated Braves (30-29), 2-1 | Atlanta-Fulton County Stadium (1-2) | 30-29 | Won 3 |
| » Starters: Rich Nye vs Ron Reed | Fourth | 5 out |
| Saturday, June 15 |
| » Lost to Braves (31-29), 3-2 | Atlanta-Fulton County Stadium (1-3) | 30-30 | |
| » Starters: Joe Niekro vs Milt Pappas | Sixth | 6 out |
| Sunday, June 16 |
| » Lost to Braves (32-29), 1-0 | Atlanta-Fulton County Stadium (1-4) | 30-31 | Lost 2 |
| » Starters: Fergie Jenkins vs Phil Niekro | Sixth | 7 out |
| Tuesday, June 18 |
| » Lost to Cardinals (39-25), 1-0 | Busch Stadium II (1-3) | 30-32 | Lost 3 |
| » Starters: Bill Hands vs Nelson Briles | Fifth | 8 out |
| Wednesday, June 19 |
| » Lost to Cardinals (40-25), 4-0 | Busch Stadium II (1-4) | 30-33 | Lost 4 |
| » Starters: Rich Nye vs Steve Carlton | Seventh | 9 out |
| Thursday, June 20 |
| » Lost to Cardinals (41-25), 1-0 | Busch Stadium II (1-5) | 30-34 | Lost 5 |
| » Starters: Fergie Jenkins vs Bob Gibson | Eighth | 10 out |
| Friday, June 21 |
| » Defeated Reds (30-35), 3-2 | Crosley Field (2-1) | 31-34 | |
| » Starters: Joe Niekro vs George Culver | Eighth | 10 out |
| Saturday, June 22 |
| » Lost to Reds (31-35), 7-1 | Crosley Field (2-2) | 31-35 | |
| » Starters: Bill Hands vs Jim Maloney | Eighth | 11 out |
| Sunday, June 23 |
| » Lost to Reds (32-35), 9-8 | Crosley Field (2-3) | 31-36 | Lost 2 |
| » Starters: Ken Holtzman vs Tony Cloninger | Ninth | 12 out |
| » Lost to Reds (33-35), 4-3 | Crosley Field (2-4) | 31-37 | Lost 3 |
| » Starters: Fergie Jenkins vs Billy McCool | Ninth | 12 out |
| Monday, June 24 |
| » Lost to Astros (28-41), 3-1 | Astrodome (2-2) | 31-38 | Lost 4 |
| » Starters: Rich Nye vs Larry Dierker | Ninth | 12½ out |
| Tuesday, June 25 |
| » Lost to Astros (29-41), 4-2 | Astrodome (2-3) | 31-39 | Lost 5 |
| » Starters: Joe Niekro vs Mike Cuellar | Ninth | 12½ out |
| Wednesday, June 26 |
| » Lost to Astros (30-41), 2-1 | Astrodome (2-4) | 31-40 | Lost 6 |
| » Starters: Bill Hands vs Dave Giusti | Ninth | 13 out |
| Friday, June 28 |
| » Lost to Cardinals (46-28), 9-5 | Wrigley Field (16-16) | 31-41 | Lost 7 |
| » Starters: Nelson Briles vs Fergie Jenkins | Eighth | 14 out |
| » Major-league debuts: Gary Ross (Cubs) |
| Saturday, June 29 |
| » Defeated Cardinals (46-29), 10-8 | Wrigley Field (17-16) | 32-41 | |
| » Starters: Ray Washburn vs Joe Niekro | Ninth | 13 out |
| Sunday, June 30 |
| » Defeated Cardinals (46-30), 6-2 | Wrigley Field (18-16) | 33-41 | Won 2 |
| » Starters: Steve Carlton vs Bill Hands | Ninth | 12 out |
| Monday, July 1 |
| » Lost to Phillies (34-36), 6-4 | Wrigley Field (18-17) | 33-42 | |
| » Starters: Chris Short vs Rich Nye | Ninth | 13 out |
| Tuesday, July 2 |
| » Defeated Phillies (34-37), 5-3 | Wrigley Field (19-17) | 34-42 | |
| » Starters: Woodie Fryman vs Fergie Jenkins | Ninth | 13 out |
| Wednesday, July 3 |
| » Lost to Phillies (35-37), 3-2 | Wrigley Field (19-18) | 34-43 | |
| » Starters: Larry Jackson vs Ken Holtzman | Ninth | 14 out |
| Thursday, July 4 |
| » Defeated Phillies (35-38), 6-2 | Wrigley Field (20-18) | 35-43 | |
| » Starters: Grant Jackson vs Joe Niekro | Ninth | 14½ out |
| » Lost to Phillies (36-38), 7-4 | Wrigley Field (20-19) | 35-44 | |
| » Starters: Jeff James vs Bill Hands | Ninth | 14½ out |
| Friday, July 5 |
| » Lost to Pirates (40-37), 4-0 | Wrigley Field (20-20) | 35-45 | Lost 2 |
| » Starters: Bob Veale vs Rich Nye | Ninth | 15½ out |
| Saturday, July 6 |
| » Defeated Pirates (40-38), 6-1 | Wrigley Field (21-20) | 36-45 | |
| » Starters: Luke Walker vs Fergie Jenkins | Ninth | 15 out |
| » Defeated Pirates (40-39), 10-2 | Wrigley Field (22-20) | 37-45 | Won 2 |
| » Starters: Tommie Sisk vs Gary Ross | Ninth | 15 out |
| Sunday, July 7 |
| » Defeated Pirates (40-40), 5-4 | Wrigley Field (23-20) | 38-45 | Won 3 |
| » Starters: Steve Blass vs Ken Holtzman | Ninth | 14½ out |
| » Defeated Pirates (40-41), 4-3 | Wrigley Field (24-20) | 39-45 | Won 4 |
| » Starters: Al McBean vs Bill Hands | Ninth | 14½ out |
| Thursday, July 11 |
| » Lost to Mets (40-43), 1-0 | Shea Stadium (2-2) | 39-46 | |
| » Starters: Fergie Jenkins vs Dick Selma | Ninth | 14½ out |
| » Defeated Mets (40-44), 2-0 | Shea Stadium (3-2) | 40-46 | |
| » Starters: Bill Hands vs Don Cardwell | Ninth | 14½ out |
| Friday, July 12 |
| » Lost to Mets (41-44), 4-0 | Shea Stadium (3-3) | 40-47 | |
| » Starters: Ken Holtzman vs Jerry Koosman | Ninth | 15½ out |
| Former Cub Kettle Wirts dies in Sacramento, CA at the age of 71. |
| Saturday, July 13 |
| » Defeated Mets (41-45), 2-1 | Shea Stadium (4-3) | 41-47 | |
| » Starters: Gary Ross vs Tom Seaver | Eighth | 15½ out |
| Sunday, July 14 |
| » Defeated Pirates (40-46), 6-2 | Forbes Field (2-3) | 42-47 | Won 2 |
| » Starters: Joe Niekro vs Al McBean | Sixth | 15½ out |
| Future Cub Derrick May is born in Rochester, NY. |
| Monday, July 15 |
| » Defeated Pirates (40-47), 2-1 | Forbes Field (3-3) | 43-47 | Won 3 |
| » Starters: Fergie Jenkins vs Bob Moose | Sixth | 15½ out |
| Tuesday, July 16 |
| » Defeated Phillies (45-41), 4-3 | Shibe Park (2-1) | 44-47 | Won 4 |
| » Starters: Ken Holtzman vs Chris Short | Fifth | 15½ out |
| Wednesday, July 17 |
| » Defeated Phillies (45-42), 8-4 | Shibe Park (3-1) | 45-47 | Won 5 |
| » Starters: Bill Hands vs Woodie Fryman | Sixth | 15½ out |
| » Lost to Phillies (46-42), 8-0 | Shibe Park (3-2) | 45-48 | |
| » Starters: Rich Nye vs Jeff James | Sixth | 15½ out |
| » Major-league debuts: Jerry Johnson (Phillies) |
| Friday, July 19 |
| » Defeated Dodgers (42-51), 6-2 | Dodger Stadium (4-1) | 46-48 | |
| » Starters: Fergie Jenkins vs Claude Osteen | Sixth | 14 out |
| Saturday, July 20 |
| » Lost to Dodgers (43-51), 5-2 | Dodger Stadium (4-2) | 46-49 | |
| » Starters: Ken Holtzman vs Don Drysdale | Sixth | 15 out |
| Sunday, July 21 |
| » Defeated Dodgers (43-52), 7-2 | Dodger Stadium (5-2) | 47-49 | |
| » Starters: Bill Hands vs Bill Singer | Fifth | 14½ out |
| Monday, July 22 |
| » Defeated Giants (48-48), 7-2 | Candlestick Park (3-2) | 48-49 | Won 2 |
| » Starters: Joe Niekro vs Ron Herbel | Sixth | 14½ out |
| Tuesday, July 23 |
| » Lost to Giants (49-48), 4-3 | Candlestick Park (3-3) | 48-50 | |
| » Starters: Fergie Jenkins vs Juan Marichal | Sixth | 15½ out |
| Wednesday, July 24 |
| » Defeated Giants (49-49), 2-0 | Candlestick Park (4-3) | 49-50 | |
| » Starters: Ken Holtzman vs Gaylord Perry | Fifth | 15½ out |
| Friday, July 26 |
| » Lost to Dodgers (45-54), 3-2 | Wrigley Field (24-21) | 49-51 | |
| » Starters: Bill Singer vs Bill Hands | Fifth | 16½ out |
| » Major-league debuts: John Felske (Cubs) |
| Saturday, July 27 |
| » Defeated Dodgers (45-55), 2-1 | Wrigley Field (25-21) | 50-51 | |
| » Starters: Claude Osteen vs Fergie Jenkins | Fifth | 16½ out |
| Sunday, July 28 |
| » Defeated Dodgers (45-56), 8-3 | Wrigley Field (26-21) | 51-51 | Won 2 |
| » Starters: Don Drysdale vs Joe Niekro | Fourth | 15 out |
| » Defeated Dodgers (45-57), 1-0 | Wrigley Field (27-21) | 52-51 | Won 3 |
| » Starters: Don Sutton vs Ken Holtzman | Fourth | 15 out |
| Monday, July 29 |
| » Lost to Giants (52-50), 4-1 | Wrigley Field (27-22) | 52-52 | |
| » Starters: Gaylord Perry vs Gary Ross | Fifth | 16 out |
| Tuesday, July 30 |
| » Defeated Giants (52-51), 10-4 | Wrigley Field (28-22) | 53-52 | |
| » Starters: Ray Sadecki vs Bill Hands | Fourth | 16 out |
| Wednesday, July 31 |
| » Defeated Astros (45-60), 6-1 | Wrigley Field (29-22) | 54-52 | Won 2 |
| » Starters: Denny Lemaster vs Fergie Jenkins | Fourth | 16 out |
| Thursday, August 1 |
| » Defeated Astros (45-61), 4-1 | Wrigley Field (30-22) | 55-52 | Won 3 |
| » Starters: Dave Giusti vs Joe Niekro | Fourth | 16 out |
| Friday, August 2 |
| » Defeated Cardinals (71-37), 3-0 | Busch Stadium II (2-5) | 56-52 | Won 4 |
| » Starters: Ken Holtzman vs Larry Jaster | Fourth | 15 out |
| Saturday, August 3 |
| » Defeated Cardinals (71-38), 3-2 | Busch Stadium II (3-5) | 57-52 | Won 5 |
| » Starters: Bill Hands vs Ray Washburn | Second | 14 out |
| Future Cub Rod Beck is born in Burbank, CA. |
| Sunday, August 4 |
| » Defeated Cardinals (71-39), 6-5 | Busch Stadium II (4-5) | 58-52 | Won 6 |
| » Starters: Fergie Jenkins vs Bob Gibson | Second | 13 out |
| Monday, August 5 |
| » Lost to Braves (58-53), 6-1 | Atlanta-Fulton County Stadium (1-5) | 58-53 | |
| » Starters: Gary Ross vs Milt Pappas | Second | 14 out |
| Tuesday, August 6 |
| » Defeated Braves (58-54), 4-3 | Atlanta-Fulton County Stadium (2-5) | 59-53 | |
| » Starters: Joe Niekro vs Pat Jarvis | Second | 13 out |
| Wednesday, August 7 |
| » Lost to Braves (59-54), 10-2 | Atlanta-Fulton County Stadium (2-6) | 59-54 | |
| » Starters: Ken Holtzman vs George Stone | Second | 14 out |
| Thursday, August 8 |
| » Defeated Braves (59-55), 4-0 | Atlanta-Fulton County Stadium (3-6) | 60-54 | |
| » Starters: Bill Hands vs Ron Reed | Second | 14 out |
| Friday, August 9 |
| » Lost to Reds (57-53), 7-3 | Crosley Field (2-5) | 60-55 | |
| » Starters: Fergie Jenkins vs Bob Lee | Second | 15 out |
| Saturday, August 10 |
| » Defeated Reds (57-54), 8-5 | Crosley Field (3-5) | 61-55 | |
| » Starters: Joe Niekro vs Gerry Arrigo | Second | 15 out |
| Sunday, August 11 |
| » Defeated Reds (57-55), 8-5 | Crosley Field (4-5) | 62-55 | Won 2 |
| » Starters: Ken Holtzman vs Jim Maloney | Second | 14 out |
| Monday, August 12 |
| » Defeated Cardinals (76-42), 7-3 | Wrigley Field (31-22) | 63-55 | Won 3 |
| » Starters: Larry Jaster vs Bill Hands | Second | 13 out |
| Tuesday, August 13 |
| » Defeated Cardinals (76-43), 10-3 | Wrigley Field (32-22) | 64-55 | Won 4 |
| » Starters: Ray Washburn vs Fergie Jenkins | Second | 12 out |
| Wednesday, August 14 |
| » Lost to Cardinals (77-43), 3-1 | Wrigley Field (32-23) | 64-56 | |
| » Starters: Bob Gibson vs Joe Niekro | Second | 13 out |
| Thursday, August 15 |
| » Lost to Cardinals (78-43), 8-0 | Wrigley Field (32-24) | 64-57 | Lost 2 |
| » Starters: Nelson Briles vs Ken Holtzman | Second | 14 out |
| » Major-league debuts: Archie Reynolds (Cubs) |
| Friday, August 16 |
| » Lost to Reds (60-56), 11-7 | Wrigley Field (32-25) | 64-58 | Lost 3 |
| » Starters: Jim Maloney vs Bill Hands | Second | 14 out |
| Saturday, August 17 |
| » Lost to Reds (61-56), 4-0 | Wrigley Field (32-26) | 64-59 | Lost 4 |
| » Starters: Tony Cloninger vs Fergie Jenkins | Fourth | 14 out |
| Sunday, August 18 |
| » Lost to Reds (62-56), 2-1 | Wrigley Field (32-27) | 64-60 | Lost 5 |
| » Starters: George Culver vs Rich Nye | Fourth | 15½ out |
| » Lost to Reds (63-56), 6-3 | Wrigley Field (32-28) | 64-61 | Lost 6 |
| » Starters: Gary Nolan vs Joe Niekro | Fourth | 15½ out |
| Monday, August 19 |
| » Defeated Braves (63-61), 5-1 | Wrigley Field (33-28) | 65-61 | |
| » Starters: George Stone vs Ken Holtzman | Fourth | 15½ out |
| Tuesday, August 20 |
| » Defeated Braves (63-62), 6-5 | Wrigley Field (34-28) | 66-61 | Won 2 |
| » Starters: Phil Niekro vs Bill Hands | Fourth | 14½ out |
| Wednesday, August 21 |
| » Defeated Braves (63-63), 5-4 | Wrigley Field (35-28) | 67-61 | Won 3 |
| » Starters: Milt Pappas vs Fergie Jenkins | Third | 14 out |
| » Defeated Braves (63-64), 13-5 | Wrigley Field (36-28) | 68-61 | Won 4 |
| » Starters: Ron Reed vs Rich Nye | Third | 14 out |
| Future Cub Tuffy Rhodes is born in Cincinnati, OH. |
| Thursday, August 22 |
| Future Cub Gary Scott is born in New Rochelle, NY. |
| Friday, August 23 |
| » Lost to Astros (60-69), 3-2 | Astrodome (2-5) | 68-62 | |
| » Starters: Joe Niekro vs Mike Cuellar | Fourth | 14½ out |
| Saturday, August 24 |
| » Lost to Astros (61-69), 5-1 | Astrodome (2-6) | 68-63 | Lost 2 |
| » Starters: Ken Holtzman vs Dave Giusti | Fourth | 14½ out |
| Sunday, August 25 |
| » Defeated Astros (61-70), 2-0 | Astrodome (3-6) | 69-63 | |
| » Starters: Fergie Jenkins vs Larry Dierker | Fourth | 14½ out |
| Monday, August 26 |
| » Lost to Giants (70-60), 3-0 | Candlestick Park (4-4) | 69-64 | |
| » Starters: Bill Hands vs Gaylord Perry | Fourth | 14½ out |
| Tuesday, August 27 |
| » Lost to Giants (71-60), 8-4 | Candlestick Park (4-5) | 69-65 | Lost 2 |
| » Starters: Archie Reynolds vs Bobby Bolin | Fourth | 14½ out |
| Wednesday, August 28 |
| » Defeated Dodgers (56-76), 7-4 | Dodger Stadium (6-2) | 70-65 | |
| » Starters: Rich Nye vs Bill Singer | Fourth | 15 out |
| » Lost to Dodgers (57-76), 8-4 | Dodger Stadium (6-3) | 70-66 | |
| » Starters: Darcy Fast vs John Purdin | Fourth | 15 out |
| Friday, August 30 |
| » Defeated Astros (63-73), 5-3 | Wrigley Field (37-28) | 71-66 | |
| » Starters: Larry Dierker vs Fergie Jenkins | Fourth | 14½ out |
| Saturday, August 31 |
| » Lost to Astros (64-73), 6-2 | Wrigley Field (37-29) | 71-67 | |
| » Starters: Don Wilson vs Joe Niekro | Fourth | 15½ out |
| Sunday, September 1 |
| » Defeated Astros (64-74), 2-0 | Wrigley Field (38-29) | 72-67 | |
| » Starters: Denny Lemaster vs Bill Hands | Fourth | 15½ out |
| Monday, September 2 |
| » Lost to Giants (74-63), 8-4 | Wrigley Field (38-30) | 72-68 | |
| » Starters: Juan Marichal vs Ken Holtzman | Fourth | 16½ out |
| » Tied Giants, 1-1 | Wrigley Field (38-30) | 72-68 | |
| » Starters: Bobby Bolin vs Gary Ross | Fourth | 16½ out |
| Tuesday, September 3 |
| » Defeated Giants (74-64), 8-3 | Wrigley Field (39-30) | 73-68 | |
| » Starters: Gaylord Perry vs Fergie Jenkins | Fourth | 16½ out |
| Wednesday, September 4 |
| » Defeated Giants (74-65), 7-6 | Wrigley Field (40-30) | 74-68 | Won 2 |
| » Starters: Mike McCormick vs Joe Niekro | Fourth | 16 out |
| » Lost to Giants (75-65), 5-4 | Wrigley Field (40-31) | 74-69 | |
| » Starters: Ron Herbel vs Ken Holtzman | Fourth | 16 out |
| Friday, September 6 |
| » Lost to Phillies (66-75), 5-2 | Wrigley Field (40-32) | 74-70 | Lost 2 |
| » Starters: Rick Wise vs Bill Hands | Fourth | 15½ out |
| Saturday, September 7 |
| » Lost to Phillies (67-75), 4-2 | Wrigley Field (40-33) | 74-71 | Lost 3 |
| » Starters: Jerry Johnson vs Fergie Jenkins | Fourth | 15½ out |
| Sunday, September 8 |
| » Defeated Phillies (67-76), 10-3 | Wrigley Field (41-33) | 75-71 | |
| » Starters: Woodie Fryman vs Ken Holtzman | Fourth | 15½ out |
| Tuesday, September 10 |
| » Defeated Mets (65-82), 8-1 | Wrigley Field (42-33) | 76-71 | Won 2 |
| » Starters: Dick Selma vs Bill Hands | Third | 14 out |
| » Major-league debuts: Mike Jorgensen (Mets) |
| Wednesday, September 11 |
| » Lost to Mets (66-82), 1-0 | Wrigley Field (42-34) | 76-72 | |
| » Starters: Jim McAndrew vs Fergie Jenkins | Fourth | 15 out |
| Friday, September 13 |
| » Lost to Phillies (70-77), 3-1 | Shibe Park (3-3) | 76-73 | Lost 2 |
| » Starters: Ken Holtzman vs Chris Short | Fourth | 14½ out |
| » Defeated Phillies (70-78), 9-1 | Shibe Park (4-3) | 77-73 | |
| » Starters: Rich Nye vs Jerry Johnson | Fourth | 14½ out |
| Saturday, September 14 |
| » Lost to Phillies (71-78), 4-1 | Shibe Park (4-4) | 77-74 | |
| » Starters: Bill Hands vs Larry Jackson | Fourth | 15½ out |
| Former Cub Hans Lobert dies in Philadelphia, PA at the age of 87. |
| Sunday, September 15 |
| » Defeated Phillies (71-79), 4-0 | Shibe Park (5-4) | 78-74 | |
| » Starters: Fergie Jenkins vs Grant Jackson | Fourth | 15½ out |
| Tuesday, September 17 |
| » Lost to Mets (68-84), 3-2 | Shea Stadium (4-4) | 78-75 | |
| » Starters: Ken Holtzman vs Jim McAndrew | Fourth | 15½ out |
| Wednesday, September 18 |
| » Defeated Mets (68-85), 7-2 | Shea Stadium (5-4) | 79-75 | |
| » Starters: Bill Hands vs Jerry Koosman | Fourth | 15½ out |
| Friday, September 20 |
| » Lost to Pirates (76-77), 5-0 | Forbes Field (3-4) | 79-76 | |
| » Starters: Fergie Jenkins vs Steve Blass | Fourth | 15 out |
| Saturday, September 21 |
| » Lost to Pirates (77-77), 5-1 | Forbes Field (3-5) |
