| Sunday, January 21 |
| Future Cardinal Tom Urbani is born in Santa Cruz, CA. |
| Thursday, February 1 |
| Future Cardinal Kent Mercker is born in Indianapolis, IN. |
| Sunday, March 3 |
| Future Cardinal Scott Radinsky is born in Glendale, CA. |
| Monday, March 4 |
| Future Cardinal Brian Hunter is born in Torrance, CA. |
| Wednesday, March 20 |
| Former Cardinal Clyde Shoun dies in Mountain Home, TN at the age of 57. |
| Sunday, March 31 |
| Former Cardinal Grover Lowdermilk dies in Odin, IL at the age of 84. |
| Wednesday, April 10 |
| » Defeated Braves (0-1), 2-1 | Busch Stadium II (1-0) | 1-0 | |
| » Starters: Pat Jarvis vs Bob Gibson | First | -- |
| Thursday, April 11 |
| » Defeated Braves (0-2), 10-3 | Busch Stadium II (2-0) | 2-0 | Won 2 |
| » Starters: Dick Kelley vs Nelson Briles | First | -- |
| Saturday, April 13 |
| » Defeated Cubs (1-2), 8-5 | Wrigley Field (1-0) | 3-0 | Won 3 |
| » Starters: Steve Carlton vs Rich Nye | Second | ½ out |
| Sunday, April 14 |
| » Lost to Cubs (2-2), 7-6 | Wrigley Field (1-1) | 3-1 | |
| » Starters: Dick Hughes vs Joe Niekro | Second | ½ out |
| Monday, April 15 |
| » Defeated Braves (2-3), 4-3 | Atlanta-Fulton County Stadium (1-0) | 4-1 | |
| » Starters: Bob Gibson vs Pat Jarvis | Second | ½ out |
| Tuesday, April 16 |
| » Defeated Braves (2-4), 6-2 | Atlanta-Fulton County Stadium (2-0) | 5-1 | Won 2 |
| » Starters: Nelson Briles vs Tony Cloninger | First | -- |
| Wednesday, April 17 |
| » Lost to Reds (3-3), 4-3 | Crosley Field (0-1) | 5-2 | |
| » Starters: Steve Carlton vs Milt Pappas | First | -- |
| Thursday, April 18 |
| » Lost to Reds (4-3), 4-3 | Crosley Field (0-2) | 5-3 | Lost 2 |
| » Starters: Ray Washburn vs George Culver | Third | ½ out |
| Friday, April 19 |
| » Defeated Cubs (2-6), 9-2 | Busch Stadium II (3-0) | 6-3 | |
| » Starters: Rich Nye vs Mike Torrez | First | -- |
| » Major-league debuts: Bill Plummer (Cubs) |
| Saturday, April 20 |
| » Lost to Cubs (3-6), 5-1 | Busch Stadium II (3-1) | 6-4 | |
| » Starters: Fergie Jenkins vs Bob Gibson | Second | ½ out |
| Sunday, April 21 |
| » Defeated Cubs (3-7), 9-2 | Busch Stadium II (4-1) | 7-4 | |
| » Starters: Ken Holtzman vs Nelson Briles | First | -- |
| Tuesday, April 23 |
| » Defeated Reds (5-6), 4-2 | Busch Stadium II (5-1) | 8-4 | Won 2 |
| » Starters: George Culver vs Steve Carlton | First | -- |
| Wednesday, April 24 |
| » Defeated Reds (5-7), 7-0 | Busch Stadium II (6-1) | 9-4 | Won 3 |
| » Starters: John Tsitouris vs Ray Washburn | First | -- |
| Friday, April 26 |
| » Defeated Pirates (6-6), 2-1 | Busch Stadium II (7-1) | 10-4 | Won 4 |
| » Starters: Bob Veale vs Bob Gibson | First | -- |
| Saturday, April 27 |
| » Defeated Pirates (6-7), 7-5 | Busch Stadium II (8-1) | 11-4 | Won 5 |
| » Starters: Al McBean vs Nelson Briles | First | -- |
| Sunday, April 28 |
| » Defeated Pirates (6-8), 4-2 | Busch Stadium II (9-1) | 12-4 | Won 6 |
| » Starters: Tommie Sisk vs Steve Carlton | First | -- |
| Monday, April 29 |
| » Lost to Dodgers (9-8), 3-2 | Dodger Stadium (0-1) | 12-5 | |
| » Starters: Mike Torrez vs Don Sutton | First | -- |
| Tuesday, April 30 |
| » Defeated Dodgers (9-9), 2-1 | Dodger Stadium (1-1) | 13-5 | |
| » Starters: Ray Washburn vs Bill Singer | First | -- |
| Wednesday, May 1 |
| » Defeated Astros (7-11), 3-1 | Astrodome (1-0) | 14-5 | Won 2 |
| » Starters: Bob Gibson vs Dave Giusti | First | -- |
| Thursday, May 2 |
| » Lost to Astros (8-11), 4-0 | Astrodome (1-1) | 14-6 | |
| » Starters: Nelson Briles vs Denny Lemaster | First | -- |
| Friday, May 3 |
| » Lost to Giants (11-9), 5-4 | Candlestick Park (0-1) | 14-7 | Lost 2 |
| » Starters: Steve Carlton vs Juan Marichal | First | -- |
| Future Cardinal Ivan Cruz is born in Fajardo, P.R. |
| Saturday, May 4 |
| » Defeated Giants (11-10), 11-6 | Candlestick Park (1-1) | 15-7 | |
| » Starters: Dick Hughes vs Ray Sadecki | First | -- |
| Sunday, May 5 |
| » Lost to Giants (12-10), 8-4 | Candlestick Park (1-2) | 15-8 | |
| » Starters: Ray Washburn vs Mike McCormick | First | -- |
| Monday, May 6 |
| » Defeated Mets (9-13), 2-1 | Busch Stadium II (10-1) | 16-8 | |
| » Starters: Tom Seaver vs Bob Gibson | First | -- |
| Tuesday, May 7 |
| » Lost to Mets (10-13), 4-1 | Busch Stadium II (10-2) | 16-9 | |
| » Starters: Nolan Ryan vs Nelson Briles | First | -- |
| Wednesday, May 8 |
| » Defeated Mets (10-14), 2-0 | Busch Stadium II (11-2) | 17-9 | |
| » Starters: Al Jackson vs Steve Carlton | First | -- |
| Saturday, May 11 |
| » Defeated Astros (12-15), 4-3 | Busch Stadium II (12-2) | 18-9 | Won 2 |
| » Starters: Denny Lemaster vs Ray Washburn | First | -- |
| Sunday, May 12 |
| » Lost to Astros (13-15), 3-2 | Busch Stadium II (12-3) | 18-10 | |
| » Starters: Larry Dierker vs Bob Gibson | First | -- |
| Future Cardinal Mark Clark is born in Bath, IL. |
| Monday, May 13 |
| » Defeated Pirates (14-14), 1-0 | Forbes Field (1-0) | 19-10 | |
| » Starters: Nelson Briles vs Jim Bunning | First | -- |
| Wednesday, May 15 |
| » Defeated Pirates (14-15), 1-0 | Forbes Field (2-0) | 20-10 | Won 2 |
| » Starters: Steve Carlton vs Steve Blass | First | -- |
| Thursday, May 16 |
| » Lost to Pirates (15-15), 3-0 | Forbes Field (2-1) | 20-11 | |
| » Starters: Ray Washburn vs Bob Veale | First | -- |
| Friday, May 17 |
| » Lost to Phillies (15-16), 1-0 | Shibe Park (0-1) | 20-12 | Lost 2 |
| » Starters: Bob Gibson vs Woodie Fryman | First | -- |
| Saturday, May 18 |
| » Lost to Phillies (16-16), 3-2 | Shibe Park (0-2) | 20-13 | Lost 3 |
| » Starters: Nelson Briles vs Larry Jackson | First | -- |
| Sunday, May 19 |
| » Lost to Phillies (17-16), 4-3 | Shibe Park (0-3) | 20-14 | Lost 4 |
| » Starters: Steve Carlton vs Chris Short | First | -- |
| Monday, May 20 |
| » Defeated Dodgers (17-21), 2-1 | Busch Stadium II (13-3) | 21-14 | |
| » Starters: Don Sutton vs Larry Jaster | First | -- |
| Tuesday, May 21 |
| » Lost to Dodgers (18-21), 9-2 | Busch Stadium II (13-4) | 21-15 | |
| » Starters: Bill Singer vs Ray Washburn | First | -- |
| Wednesday, May 22 |
| » Lost to Dodgers (19-21), 2-0 | Busch Stadium II (13-5) | 21-16 | Lost 2 |
| » Starters: Don Drysdale vs Bob Gibson | First | -- |
| Thursday, May 23 |
| » Lost to Dodgers (20-21), 3-2 | Busch Stadium II (13-6) | 21-17 | Lost 3 |
| » Starters: Claude Osteen vs Nelson Briles | Second | 1 out |
| Friday, May 24 |
| » Defeated Phillies (18-18), 5-1 | Busch Stadium II (14-6) | 22-17 | |
| » Starters: Chris Short vs Steve Carlton | Second | 1 out |
| Saturday, May 25 |
| » Lost to Phillies (19-18), 1-0 | Busch Stadium II (14-7) | 22-18 | |
| » Starters: Larry Jackson vs Larry Jaster | Second | 1 out |
| Sunday, May 26 |
| » Lost to Phillies (20-18), 9-3 | Busch Stadium II (14-8) | 22-19 | Lost 2 |
| » Starters: Woodie Fryman vs Ray Washburn | Second | 1 out |
| Tuesday, May 28 |
| » Lost to Giants (25-19), 3-1 | Busch Stadium II (14-9) | 22-20 | Lost 3 |
| » Starters: Gaylord Perry vs Bob Gibson | Fourth | 2 out |
| Wednesday, May 29 |
| » Lost to Giants (26-19), 2-1 | Busch Stadium II (14-10) | 22-21 | Lost 4 |
| » Starters: Juan Marichal vs Nelson Briles | Fourth | 3 out |
| Thursday, May 30 |
| » Defeated Giants (26-20), 6-0 | Busch Stadium II (15-10) | 23-21 | |
| » Starters: Ray Sadecki vs Steve Carlton | Fourth | 2 out |
| Friday, May 31 |
| » Defeated Mets (20-24), 2-0 | Shea Stadium (1-0) | 24-21 | Won 2 |
| » Starters: Larry Jaster vs Tom Seaver | Third | 1 out |
| Saturday, June 1 |
| » Defeated Mets (20-25), 6-5 | Shea Stadium (2-0) | 25-21 | Won 3 |
| » Starters: Ray Washburn vs Nolan Ryan | First | -- |
| Sunday, June 2 |
| » Defeated Mets (20-26), 6-3 | Shea Stadium (3-0) | 26-21 | Won 4 |
| » Starters: Bob Gibson vs Al Jackson | First | -- |
| » Defeated Mets (20-27), 3-2 | Shea Stadium (4-0) | 27-21 | Won 5 |
| » Starters: Dick Hughes vs Don Cardwell | First | -- |
| Monday, June 3 |
| » Defeated Astros (21-27), 7-2 | Astrodome (2-1) | 28-21 | Won 6 |
| » Starters: Nelson Briles vs Denny Lemaster | First | -- |
| Tuesday, June 4 |
| » Defeated Astros (21-28), 3-2 | Astrodome (3-1) | 29-21 | Won 7 |
| » Starters: Steve Carlton vs Mike Cuellar | First | -- |
| Wednesday, June 5 |
| » Defeated Astros (21-29), 3-1 | Astrodome (4-1) | 30-21 | Won 8 |
| » Starters: Larry Jaster vs Larry Dierker | First | -- |
| » Major-league debuts: Wayne Granger (Cardinals) |
| Thursday, June 6 |
| » Defeated Astros (21-30), 4-0 | Astrodome (5-1) | 31-21 | Won 9 |
| » Starters: Bob Gibson vs Don Wilson | First | -- |
| Friday, June 7 |
| » Lost to Reds (26-24), 4-2 | Crosley Field (0-3) | 31-22 | |
| » Starters: Dick Hughes vs Jim Maloney | First | -- |
| Saturday, June 8 |
| » Defeated Reds (26-25), 7-2 | Crosley Field (1-3) | 32-22 | |
| » Starters: Nelson Briles vs George Culver | First | -- |
| Sunday, June 9 |
| » Defeated Reds (26-26), 10-8 | Crosley Field (2-3) | 33-22 | Won 2 |
| » Starters: Steve Carlton vs Gerry Arrigo | First | -- |
| » Lost to Reds (27-26), 7-6 | Crosley Field (2-4) | 33-23 | |
| » Starters: Ray Washburn vs Billy McCool | First | -- |
| Monday, June 10 |
| » Defeated Braves (29-26), 4-3 | Atlanta-Fulton County Stadium (3-0) | 34-23 | |
| » Starters: Larry Jaster vs Phil Niekro | First | -- |
| Tuesday, June 11 |
| » Defeated Braves (29-27), 6-0 | Atlanta-Fulton County Stadium (4-0) | 35-23 | Won 2 |
| » Starters: Bob Gibson vs Dick Kelley | First | -- |
| Wednesday, June 12 |
| » Lost to Braves (30-27), 7-1 | Atlanta-Fulton County Stadium (4-1) | 35-24 | |
| » Starters: Nelson Briles vs Pat Jarvis | First | -- |
| Thursday, June 13 |
| » Defeated Braves (30-28), 3-1 | Atlanta-Fulton County Stadium (5-1) | 36-24 | |
| » Starters: Steve Carlton vs Ken Johnson | First | -- |
| Friday, June 14 |
| » Lost to Reds (29-29), 7-0 | Busch Stadium II (15-11) | 36-25 | |
| » Starters: Billy McCool vs Larry Jaster | First | -- |
| Saturday, June 15 |
| » Defeated Reds (29-30), 2-0 | Busch Stadium II (16-11) | 37-25 | |
| » Starters: Gary Nolan vs Bob Gibson | First | -- |
| Sunday, June 16 |
| » Defeated Reds (29-31), 4-2 | Busch Stadium II (17-11) | 38-25 | Won 2 |
| » Starters: George Culver vs Ray Washburn | First | -- |
| Tuesday, June 18 |
| » Defeated Cubs (30-32), 1-0 | Busch Stadium II (18-11) | 39-25 | Won 3 |
| » Starters: Bill Hands vs Nelson Briles | First | -- |
| Wednesday, June 19 |
| » Defeated Cubs (30-33), 4-0 | Busch Stadium II (19-11) | 40-25 | Won 4 |
| » Starters: Rich Nye vs Steve Carlton | First | -- |
| Thursday, June 20 |
| » Defeated Cubs (30-34), 1-0 | Busch Stadium II (20-11) | 41-25 | Won 5 |
| » Starters: Fergie Jenkins vs Bob Gibson | First | -- |
| Friday, June 21 |
| » Defeated Braves (35-31), 4-3 | Busch Stadium II (21-11) | 42-25 | Won 6 |
| » Starters: Phil Niekro vs Larry Jaster | First | -- |
| Saturday, June 22 |
| » Defeated Braves (35-32), 6-1 | Busch Stadium II (22-11) | 43-25 | Won 7 |
| » Starters: Pat Jarvis vs Ray Washburn | First | -- |
| Sunday, June 23 |
| » Lost to Braves (36-32), 5-1 | Busch Stadium II (22-12) | 43-26 | |
| » Starters: Dick Kelley vs Mel Nelson | First | -- |
| » Defeated Braves (36-33), 3-1 | Busch Stadium II (23-12) | 44-26 | |
| » Starters: Ken Johnson vs Nelson Briles | First | -- |
| Tuesday, June 25 |
| » Lost to Pirates (32-35), 3-2 | Busch Stadium II (23-13) | 44-27 | |
| » Starters: Bob Veale vs Steve Carlton | First | -- |
| Wednesday, June 26 |
| » Defeated Pirates (32-36), 3-0 | Busch Stadium II (24-13) | 45-27 | |
| » Starters: Al McBean vs Bob Gibson | First | -- |
| » Lost to Pirates (33-36), 3-1 | Busch Stadium II (24-14) | 45-28 | |
| » Starters: Steve Blass vs Larry Jaster | First | -- |
| Friday, June 28 |
| » Defeated Cubs (31-41), 9-5 | Wrigley Field (2-1) | 46-28 | |
| » Starters: Nelson Briles vs Fergie Jenkins | First | -- |
| » Major-league debuts: Gary Ross (Cubs) |
| Saturday, June 29 |
| » Lost to Cubs (32-41), 10-8 | Wrigley Field (2-2) | 46-29 | |
| » Starters: Ray Washburn vs Joe Niekro | First | -- |
| Sunday, June 30 |
| » Lost to Cubs (33-41), 6-2 | Wrigley Field (2-3) | 46-30 | Lost 2 |
| » Starters: Steve Carlton vs Bill Hands | First | -- |
| Monday, July 1 |
| » Defeated Dodgers (40-39), 5-1 | Dodger Stadium (2-1) | 47-30 | |
| » Starters: Bob Gibson vs Don Drysdale | First | -- |
| Tuesday, July 2 |
| » Defeated Dodgers (40-40), 5-3 | Dodger Stadium (3-1) | 48-30 | Won 2 |
| » Starters: Larry Jaster vs Bill Singer | First | -- |
| Wednesday, July 3 |
| » Defeated Dodgers (40-41), 2-1 | Dodger Stadium (4-1) | 49-30 | Won 3 |
| » Starters: Nelson Briles vs Mike Kekich | First | -- |
| Thursday, July 4 |
| » Defeated Dodgers (40-42), 3-2 | Dodger Stadium (5-1) | 50-30 | Won 4 |
| » Starters: Ray Washburn vs Claude Osteen | First | -- |
| Friday, July 5 |
| » Defeated Giants (42-40), 4-3 | Candlestick Park (2-2) | 51-30 | Won 5 |
| » Starters: Steve Carlton vs Mike McCormick | First | -- |
| Saturday, July 6 |
| » Defeated Giants (42-41), 3-0 | Candlestick Park (3-2) | 52-30 | Won 6 |
| » Starters: Bob Gibson vs Juan Marichal | First | -- |
| Sunday, July 7 |
| » Defeated Giants (42-42), 2-0 | Candlestick Park (4-2) | 53-30 | Won 7 |
| » Starters: Larry Jaster vs Gaylord Perry | First | -- |
| Thursday, July 11 |
| » Lost to Astros (36-48), 5-4 | Busch Stadium II (24-15) | 53-31 | |
| » Starters: Larry Dierker vs Nelson Briles | First | -- |
| » Defeated Astros (36-49), 8-7 | Busch Stadium II (25-15) | 54-31 | |
| » Starters: Mike Cuellar vs Mel Nelson | First | -- |
| Friday, July 12 |
| » Defeated Astros (36-50), 8-1 | Busch Stadium II (26-15) | 55-31 | Won 2 |
| » Starters: Denny Lemaster vs Bob Gibson | First | -- |
| Saturday, July 13 |
| » Defeated Astros (36-51), 5-4 | Busch Stadium II (27-15) | 56-31 | Won 3 |
| » Starters: Wade Blasingame vs Steve Carlton | First | -- |
| Sunday, July 14 |
| » Defeated Dodgers (41-48), 5-1 | Busch Stadium II (28-15) | 57-31 | Won 4 |
| » Starters: Mike Kekich vs Larry Jaster | First | -- |
| Monday, July 15 |
| » Defeated Dodgers (41-49), 4-2 | Busch Stadium II (29-15) | 58-31 | Won 5 |
| » Starters: Claude Osteen vs Ray Washburn | First | -- |
| Tuesday, July 16 |
| » Defeated Giants (45-45), 6-1 | Busch Stadium II (30-15) | 59-31 | Won 6 |
| » Starters: Ray Sadecki vs Nelson Briles | First | -- |
| Thursday, July 18 |
| » Lost to Giants (46-45), 3-0 | Busch Stadium II (30-16) | 59-32 | |
| » Starters: Juan Marichal vs Steve Carlton | First | -- |
| Friday, July 19 |
| » Lost to Mets (44-50), 4-2 | Busch Stadium II (30-17) | 59-33 | Lost 2 |
| » Starters: Al Jackson vs Larry Jaster | First | -- |
| Saturday, July 20 |
| » Defeated Mets (44-51), 2-0 | Busch Stadium II (31-17) | 60-33 | |
| » Starters: Dick Selma vs Ray Washburn | First | -- |
| Sunday, July 21 |
| » Defeated Mets (44-52), 2-0 | Busch Stadium II (32-17) | 61-33 | Won 2 |
| » Starters: Jim McAndrew vs Bob Gibson | First | -- |
| » Lost to Mets (45-52), 1-0 | Busch Stadium II (32-18) | 61-34 | |
| » Starters: Jerry Koosman vs Nelson Briles | First | -- |
| » Major-league debuts: Jim McAndrew (Mets) |
| Monday, July 22 |
| » Defeated Phillies (46-46), 5-4 | Busch Stadium II (33-18) | 62-34 | |
| » Starters: Woodie Fryman vs Steve Carlton | First | -- |
| Tuesday, July 23 |
| » Defeated Phillies (46-47), 11-5 | Busch Stadium II (34-18) | 63-34 | Won 2 |
| » Starters: Jeff James vs Larry Jaster | First | -- |
| Wednesday, July 24 |
| » Defeated Phillies (46-48), 3-1 | Busch Stadium II (35-18) | 64-34 | Won 3 |
| » Starters: Larry Jackson vs Ray Washburn | First | -- |
| Thursday, July 25 |
| » Defeated Phillies (46-49), 5-0 | Busch Stadium II (36-18) | 65-34 | Won 4 |
| » Starters: Chris Short vs Bob Gibson | First | -- |
| Friday, July 26 |
| » Defeated Pirates (45-52), 9-1 | Forbes Field (3-1) | 66-34 | Won 5 |
| » Starters: Nelson Briles vs Steve Blass | First | -- |
| » Lost to Pirates (46-52), 5-4 | Forbes Field (3-2) | 66-35 | |
| » Starters: Mel Nelson vs Jim Bunning | First | -- |
| Future Cardinal Mike Mohler is born in Dayton, OH. |
| Saturday, July 27 |
| » Defeated Pirates (46-53), 4-0 | Forbes Field (4-2) | 67-35 | |
| » Starters: Steve Carlton vs Bob Moose | First | -- |
| Former Cardinal Babe Adams dies in Silver Spring, MD at the age of 87. |
| Sunday, July 28 |
| » Lost to Pirates (47-53), 7-1 | Forbes Field (4-3) | 67-36 | |
| » Starters: Larry Jaster vs Al McBean | First | -- |
| Monday, July 29 |
| » Defeated Mets (49-56), 5-1 | Shea Stadium (5-0) | 68-36 | |
| » Starters: Ray Washburn vs Nolan Ryan | First | -- |
| Tuesday, July 30 |
| » Defeated Mets (49-57), 7-1 | Shea Stadium (6-0) | 69-36 | Won 2 |
| » Starters: Bob Gibson vs Dick Selma | First | -- |
| Wednesday, July 31 |
| » Defeated Phillies (48-55), 3-2 | Shibe Park (1-3) | 70-36 | Won 3 |
| » Starters: Nelson Briles vs Woodie Fryman | First | -- |
| Thursday, August 1 |
| » Defeated Phillies (48-56), 2-1 | Shibe Park (2-3) | 71-36 | Won 4 |
| » Starters: Steve Carlton vs Larry Jackson | First | -- |
| Friday, August 2 |
| » Lost to Cubs (56-52), 3-0 | Busch Stadium II (36-19) | 71-37 | |
| » Starters: Ken Holtzman vs Larry Jaster | First | -- |
| Future Cardinal Frank Cimorelli is born in Poughkeepsie, NY. |
| Saturday, August 3 |
| » Lost to Cubs (57-52), 3-2 | Busch Stadium II (36-20) | 71-38 | Lost 2 |
| » Starters: Bill Hands vs Ray Washburn | First | -- |
| Sunday, August 4 |
| » Lost to Cubs (58-52), 6-5 | Busch Stadium II (36-21) | 71-39 | Lost 3 |
| » Starters: Fergie Jenkins vs Bob Gibson | First | -- |
| Monday, August 5 |
| » Defeated Reds (55-51), 3-2 | Busch Stadium II (37-21) | 72-39 | |
| » Starters: Gerry Arrigo vs Nelson Briles | First | -- |
| Tuesday, August 6 |
| » Lost to Reds (56-51), 5-0 | Busch Stadium II (37-22) | 72-40 | |
| » Starters: Jim Maloney vs Steve Carlton | First | -- |
| Wednesday, August 7 |
| » Defeated Reds (56-52), 3-1 | Busch Stadium II (38-22) | 73-40 | |
| » Starters: George Culver vs Mel Nelson | First | -- |
| Thursday, August 8 |
| » Defeated Reds (56-53), 1-0 | Busch Stadium II (39-22) | 74-40 | Won 2 |
| » Starters: Tony Cloninger vs Ray Washburn | First | -- |
| Friday, August 9 |
| » Defeated Braves (59-56), 1-0 | Atlanta-Fulton County Stadium (6-1) | 75-40 | Won 3 |
| » Starters: Bob Gibson vs Phil Niekro | First | -- |
| Saturday, August 10 |
| » Defeated Braves (59-57), 7-1 | Atlanta-Fulton County Stadium (7-1) | 76-40 | Won 4 |
| » Starters: Nelson Briles vs Milt Pappas | First | -- |
| Sunday, August 11 |
| » Lost to Braves (60-57), 5-3 | Atlanta-Fulton County Stadium (7-2) | 76-41 | |
| » Starters: Steve Carlton vs Pat Jarvis | First | -- |
| Monday, August 12 |
| » Lost to Cubs (63-55), 7-3 | Wrigley Field (2-4) | 76-42 | Lost 2 |
| » Starters: Larry Jaster vs Bill Hands | First | -- |
| Tuesday, August 13 |
| » Lost to Cubs (64-55), 10-3 | Wrigley Field (2-5) | 76-43 | Lost 3 |
| » Starters: Ray Washburn vs Fergie Jenkins | First | -- |
| Wednesday, August 14 |
| » Defeated Cubs (64-56), 3-1 | Wrigley Field (3-5) | 77-43 | |
| » Starters: Bob Gibson vs Joe Niekro | First | -- |
| Thursday, August 15 |
| » Defeated Cubs (64-57), 8-0 | Wrigley Field (4-5) | 78-43 | Won 2 |
| » Starters: Nelson Briles vs Ken Holtzman | First | -- |
| » Major-league debuts: Archie Reynolds (Cubs) |
| Friday, August 16 |
| » Lost to Braves (62-59), 5-1 | Busch Stadium II (39-23) | 78-44 | |
| » Starters: Milt Pappas vs Steve Carlton | First | -- |
| Saturday, August 17 |
| » Lost to Braves (63-59), 3-2 | Busch Stadium II (39-24) | 78-45 | Lost 2 |
| » Starters: Pat Jarvis vs Larry Jaster | First | -- |
| Former Cardinal Forrest More dies in Columbus, IN at the age of 85. |
| Sunday, August 18 |
| » Defeated Braves (63-60), 10-1 | Busch Stadium II (40-24) | 79-45 | |
| » Starters: Ron Reed vs Ray Washburn | First | -- |
| Monday, August 19 |
| » Defeated Phillies (56-66), 2-0 | Shibe Park (3-3) | 80-45 | Won 2 |
| » Starters: Bob Gibson vs Woodie Fryman | First | -- |
| Tuesday, August 20 |
| » Lost to Phillies (57-66), 8-2 | Shibe Park (3-4) | 80-46 | |
| » Starters: Nelson Briles vs Larry Jackson | First | -- |
| Wednesday, August 21 |
| » Defeated Phillies (57-67), 8-3 | Shibe Park (4-4) | 81-46 | |
| » Starters: Steve Carlton vs Jerry Johnson | First | -- |
| Thursday, August 22 |
| » Lost to Phillies (58-67), 7-3 | Shibe Park (4-5) | 81-47 | |
| » Starters: Larry Jaster vs Chris Short | First | -- |
| Friday, August 23 |
| » Defeated Pirates (61-67), 3-2 | Busch Stadium II (41-24) | 82-47 | |
| » Starters: Bob Veale vs Ray Washburn | First | -- |
| Saturday, August 24 |
| » Lost to Pirates (62-67), 6-4 | Busch Stadium II (41-25) | 82-48 | |
| » Starters: Bob Moose vs Bob Gibson | First | -- |
| Sunday, August 25 |
| » Defeated Pirates (62-68), 4-2 | Busch Stadium II (42-25) | 83-48 | |
| » Starters: Dock Ellis vs Nelson Briles | First | -- |
| Monday, August 26 |
| » Lost to Mets (60-73), 1-0 | Busch Stadium II (42-26) | 83-49 | |
| » Starters: Jim McAndrew vs Steve Carlton | First | -- |
| Tuesday, August 27 |
| » Lost to Mets (61-73), 4-0 | Busch Stadium II (42-27) | 83-50 | Lost 2 |
| » Starters: Dick Selma vs Larry Jaster | First | -- |
| Wednesday, August 28 |
| » Defeated Pirates (64-69), 8-0 | Forbes Field (5-3) | 84-50 | |
| » Starters: Bob Gibson vs Bob Veale | First | -- |
| Thursday, August 29 |
| » Defeated Pirates (64-70), 5-0 | Forbes Field (6-3) | 85-50 | Won 2 |
| » Starters: Ray Washburn vs Bob Moose | First | -- |
| Friday, August 30 |
| » Lost to Mets (63-75), 8-2 | Shea Stadium (6-1) | 85-51 | |
| » Starters: Nelson Briles vs Tom Seaver | First | -- |
| Saturday, August 31 |
| » Defeated Mets (63-76), 2-0 | Shea Stadium (7-1) | 86-51 | |
| » Starters: Steve Carlton vs Jim McAndrew | First | -- |
| Sunday, September 1 |
| » Defeated Mets (63-77), 3-2 | Shea Stadium (8-1) | 87-51 | Won 2 |
| » Starters: Dick Hughes vs Dick Selma | First | -- |
| Monday, September 2 |
| » Defeated Reds (71-64), 1-0 | Crosley Field (3-4) | 88-51 | Won 3 |
| » Starters: Bob Gibson vs Gary Nolan | First | -- |
| Tuesday, September 3 |
| » Defeated Reds (71-65), 5-3 | Crosley Field (4-4) | 89-51 | Won 4 |
| » Starters: Ray Washburn vs George Culver | First | -- |
| » Major-league debuts: Dan McGinn (Reds) |
| Wednesday, September 4 |
| » Lost to Reds (72-65), 8-3 | Crosley Field (4-5) | 89-52 | |
| » Starters: Nelson Briles vs Jim Maloney | First | -- |
| Former Cardinal Ernie Orsatti dies in Canoga Park, CA at the age of 66. |
| Friday, September 6 |
| » Lost to Giants (76-65), 3-2 | Busch Stadium II (42-28) | 89-53 | Lost 2 |
| » Starters: Bobby Bolin vs Bob Gibson | First | -- |
| » Lost to Giants (77-65), 8-7 | Busch Stadium II (42-29) | 89-54 | Lost 3 |
| » Starters: Juan Marichal vs Steve Carlton | First | -- |
| Saturday, September 7 |
| » Lost to Giants (78-65), 5-1 | Busch Stadium II (42-30) | 89-55 | Lost 4 |
| » Starters: Gaylord Perry vs Ray Washburn | First | -- |
| Sunday, September 8 |
| » Defeated Giants (78-66), 3-2 | Busch Stadium II (43-30) | 90-55 | |
| » Starters: Mike McCormick vs Nelson Briles | First | -- |
| Monday, September 9 |
| » Lost to Dodgers (65-80), 10-1 | Busch Stadium II (43-31) | 90-56 | |
| » Starters: Don Sutton vs Larry Jaster | First | -- |
| Tuesday, September 10 |
| » Lost to Dodgers (66-80), 3-0 | Busch Stadium II (43-32) | 90-57 | Lost 2 |
| » Starters: Bill Singer vs Steve Carlton | First | -- |
| Wednesday, September 11 |
| » Defeated Dodgers (66-81), 5-4 | Busch Stadium II (44-32) | 91-57 | |
| » Starters: Mike Kekich vs Bob Gibson | First | -- |
| Friday, September 13 |
| » Lost to Astros (67-82), 4-2 | Astrodome (5-2) | 91-58 | |
| » Starters: Ray Washburn vs Dave Giusti | First | -- |
| Saturday, September 14 |
| » Defeated Astros (67-83), 8-0 | Astrodome (6-2) | 92-58 | |
| » Starters: Nelson Briles vs Larry Dierker | First | -- |
| Sunday, September 15 |
| » Defeated Astros (67-84), 7-4 | Astrodome (7-2) | 93-58 | Won 2 |
| » Starters: Steve Carlton vs Don Wilson | First | -- |
| Tuesday, September 17 |
| » Lost to Giants (82-70), 1-0 | Candlestick Park (4-3) | 93-59 | |
| » Starters: Bob Gibson vs Gaylord Perry | First | -- |
| Wednesday, September 18 |
| » Defeated Giants (82-71), 2-0 | Candlestick Park (5-3) | 94-59 | |
| » Starters: Ray Washburn vs Bobby Bolin | First | -- |
| Thursday, September 19 |
| » Lost to Giants (83-71), 11-5 | Candlestick Park (5-4) | 94-60 | |
| » Starters: Nelson Briles vs Rich Robertson | First | -- |
| » Major-league debuts: Joe Hague (Cardinals) |
| Friday, September 20 |
| » Lost to Dodgers (72-83), 5-4 | Dodger Stadium (5-2) | 94-61 | Lost 2 |
| » Starters: Steve Carlton vs Bill Singer | First | -- |
| Saturday, September 21 |
| » Lost to Dodgers (73-83), 3-0 | Dodger Stadium (5-3) | 94-62 | Lost 3 |
| » Starters: Larry Jaster vs Claude Osteen | First | -- |
| » Major-league debuts: Ted Simmons (Cardinals) |
| Sunday, September 22 |
| » Lost to |
