| Friday, January 6 |
| Former White Sox Joe Haynes dies in Hopkins, MN at the age of 50. |
| Tuesday, February 14 |
| Former White Sox Jimmy Johnston dies in Chattanooga, TN at the age of 78. |
| Monday, March 27 |
| Future White Sox Jaime Navarro is born in Bayamon, P.R. |
| Wednesday, April 12 |
| » Lost to Red Sox (1-0), 5-4 | Fenway Park (0-1) | 0-1 | |
| » W: Jim Lonborg (1-0) L: John Buzhardt (0-1) S: Don McMahon (1) | Third | 1 out |
| Thursday, April 13 |
| » Defeated Red Sox (1-1), 8-5 | Fenway Park (1-1) | 1-1 | |
| » W: Jack Lamabe (1-0) L: Hank Fischer (0-1) S: Bob Locker (1) | Third | 1 out |
| Friday, April 14 |
| » Major-league debuts: Thad Tillotson (Yankees) Russ Gibson and Billy Rohr (Red Sox) |
| Saturday, April 15 |
| » Lost to Senators (2-1), 3-1 | Comiskey Park I (0-1) | 1-2 | |
| » W: Darold Knowles (1-0) L: Dennis Higgins (0-1) | Fourth | 1½ out |
| Sunday, April 16 |
| » Defeated Senators (2-2), 7-3 | Comiskey Park I (1-1) | 2-2 | |
| » W: Joe Horlen (1-0) L: Phil Ortega (0-1) | Second | ½ out |
| » Defeated Senators (2-3), 4-3 | Comiskey Park I (2-1) | 3-2 | Won 2 |
| » W: Dennis Higgins (1-1) L: Darold Knowles (1-1) | Second | ½ out |
| Tuesday, April 18 |
| » Defeated Red Sox (2-4), 5-2 | Comiskey Park I (3-1) | 4-2 | Won 3 |
| » W: Bruce Howard (1-0) L: Bucky Brandon (0-1) | First | -- |
| Wednesday, April 19 |
| » Lost to Yankees (4-2), 3-0 | Comiskey Park I (3-2) | 4-3 | |
| » W: Whitey Ford (1-1) L: Tommy John (0-1) | Third | ½ out |
| Thursday, April 20 |
| » Defeated Senators (2-4), 8-4 | Robert F. Kennedy Stadium (1-0) | 5-3 | |
| » W: John Buzhardt (1-1) L: Pete Richert (0-2) | Second | 1 out |
| Friday, April 21 |
| » Lost to Senators (3-4), 4-3 | Robert F. Kennedy Stadium (1-1) | 5-4 | |
| » W: Joe Coleman (2-0) L: Gary Peters (0-1) | Third | 1 out |
| Saturday, April 22 |
| » Defeated Senators (3-5), 1-0 | Robert F. Kennedy Stadium (2-1) | 6-4 | |
| » W: Joe Horlen (2-0) L: Phil Ortega (0-2) | First | -- |
| Sunday, April 23 |
| » Lost to Senators (4-5), 5-1 | Robert F. Kennedy Stadium (2-2) | 6-5 | |
| » W: Barry Moore (1-0) L: Bruce Howard (1-1) | Third | ½ out |
| Tuesday, April 25 |
| » Lost to Yankees (6-4), 11-2 | Yankee Stadium (0-1) | 6-6 | Lost 2 |
| » W: Whitey Ford (2-1) L: Tommy John (0-2) | Fifth | 1 out |
| Wednesday, April 26 |
| » Defeated Yankees (6-5), 5-1 | Yankee Stadium (1-1) | 7-6 | |
| » W: Gary Peters (1-1) L: Mel Stottlemyre (2-2) | Third | ½ out |
| Friday, April 28 |
| » Defeated Indians (6-7), 3-2 | Comiskey Park I (4-2) | 8-6 | Won 2 |
| » W: Bob Locker (1-0) L: Sonny Siebert (1-1) | Third | ½ out |
| Sunday, April 30 |
| » Lost to Indians (7-7), 2-1 | Comiskey Park I (4-3) | 8-7 | |
| » W: Gary Bell (1-1) L: Bruce Howard (1-2) | Fourth | 1 out |
| » Defeated Indians (7-8), 4-2 | Comiskey Park I (5-3) | 9-7 | |
| » W: Hoyt Wilhelm (1-0) L: Steve Hargan (2-2) | Fourth | 1 out |
| Wednesday, May 3 |
| » Defeated Tigers (10-7), 2-1 | Comiskey Park I (6-3) | 10-7 | Won 2 |
| » W: Gary Peters (2-1) L: Denny McLain (2-3) S: Bob Locker (2) | First | -- |
| Friday, May 5 |
| » Defeated Indians (8-10), 3-2 | Cleveland Stadium (1-0) | 11-7 | Won 3 |
| » W: Tommy John (1-2) L: Steve Hargan (2-3) | First | -- |
| Saturday, May 6 |
| » Defeated Indians (8-11), 2-0 | Cleveland Stadium (2-0) | 12-7 | Won 4 |
| » W: Joe Horlen (3-0) L: Gary Bell (1-2) S: Bob Locker (3) | First | -- |
| Tuesday, May 9 |
| » Defeated Orioles (9-13), 5-4 | Memorial Stadium (1-0) | 13-7 | Won 5 |
| » W: Gary Peters (3-1) L: Eddie Watt (0-1) S: Bob Locker (4) | Second | ½ out |
| Wednesday, May 10 |
| » Defeated Orioles (9-14), 13-1 | Memorial Stadium (2-0) | 14-7 | Won 6 |
| » W: Tommy John (2-2) L: Steve Barber (2-3) | Second | ½ out |
| Friday, May 12 |
| » Defeated Angels (13-14), 1-0 | Comiskey Park I (7-3) | 15-7 | Won 7 |
| » W: Joe Horlen (4-0) L: Jack Sanford (1-2) S: Bob Locker (5) | Second | ½ out |
| Saturday, May 13 |
| » Defeated Angels (13-15), 1-0 | Comiskey Park I (8-3) | 16-7 | Won 8 |
| » W: Jim O'Toole (1-0) L: Minnie Rojas (3-2) | Second | ½ out |
| Sunday, May 14 |
| » Defeated Angels (13-16), 4-2 | Comiskey Park I (9-3) | 17-7 | Won 9 |
| » W: Tommy John (3-2) L: George Brunet (1-6) S: Bob Locker (6) | First | -- |
| » Defeated Angels (13-17), 3-1 | Comiskey Park I (10-3) | 18-7 | Won 10 |
| » W: Gary Peters (4-1) L: Jim Coates (0-1) | First | -- |
| Tuesday, May 16 |
| » Lost to Twins (12-15), 1-0 | Comiskey Park I (10-4) | 18-8 | |
| » W: Dean Chance (6-1) L: John Buzhardt (1-2) | First | -- |
| Wednesday, May 17 |
| » Defeated Twins (12-16), 5-4 | Comiskey Park I (11-4) | 19-8 | |
| » W: Joe Horlen (5-0) L: Jim Kaat (1-5) S: Bob Locker (7) | First | -- |
| Friday, May 19 |
| » Defeated Athletics (15-16), 9-1 | Municipal Stadium (1-0) | 20-8 | Won 2 |
| » W: Gary Peters (5-1) L: Lew Krausse (2-5) | First | -- |
| Saturday, May 20 |
| » Lost to Athletics (16-16), 9-4 | Municipal Stadium (1-1) | 20-9 | |
| » W: Paul Lindblad (2-0) L: Dennis Higgins (1-2) | First | -- |
| Sunday, May 21 |
| » Lost to Athletics (17-16), 5-4 | Municipal Stadium (1-2) | 20-10 | Lost 2 |
| » W: Jim Nash (5-3) L: Jim O'Toole (1-1) S: Jack Aker (6) | First | -- |
| Monday, May 22 |
| » Lost to Twins (16-16), 8-7 | Metropolitan Stadium (0-1) | 20-11 | Lost 3 |
| » W: Ron Kline (2-0) L: Bob Locker (1-1) S: Al Worthington (5) | Second | ½ out |
| Tuesday, May 23 |
| » Defeated Twins (16-17), 5-4 | Metropolitan Stadium (1-1) | 21-11 | |
| » W: John Buzhardt (2-2) L: Mudcat Grant (3-5) S: Hoyt Wilhelm (1) | First | -- |
| Wednesday, May 24 |
| » Defeated Twins (16-18), 14-1 | Metropolitan Stadium (2-1) | 22-11 | Won 2 |
| » W: Gary Peters (6-1) L: Dean Chance (7-2) | First | -- |
| Friday, May 26 |
| » Lost to Angels (17-22), 7-2 | Anaheim Stadium (0-1) | 22-12 | |
| » W: Pete Cimino (2-1) L: Tommy John (3-3) | First | -- |
| » Defeated Angels (17-23), 2-1 | Anaheim Stadium (1-1) | 23-12 | |
| » W: Jim O'Toole (2-1) L: Minnie Rojas (3-3) S: Hoyt Wilhelm (2) | First | -- |
| Future White Sox Stacy Jones is born in Gadsden, AL. |
| Saturday, May 27 |
| » Defeated Angels (17-24), 3-1 | Anaheim Stadium (2-1) | 24-12 | Won 2 |
| » W: Joe Horlen (6-0) L: Rickey Clark (2-4) | First | -- |
| Sunday, May 28 |
| » Lost to Angels (18-24), 5-0 | Anaheim Stadium (2-2) | 24-13 | |
| » W: Jim McGlothlin (4-1) L: John Buzhardt (2-3) | First | -- |
| Tuesday, May 30 |
| » Lost to Tigers (25-14), 4-2 | Tiger Stadium (0-1) | 24-14 | Lost 2 |
| » W: Earl Wilson (7-3) L: Gary Peters (6-2) S: Fred Gladding (8) | Second | 1½ out |
| » Lost to Tigers (26-14), 4-3 | Tiger Stadium (0-2) | 24-15 | Lost 3 |
| » W: Dave Wickersham (3-0) L: Bruce Howard (1-3) S: Fred Gladding (9) | Second | 1½ out |
| Wednesday, May 31 |
| » Defeated Orioles (20-20), 3-2 | Comiskey Park I (12-4) | 25-15 | |
| » W: Hoyt Wilhelm (2-0) L: Eddie Watt (0-2) | Second | ½ out |
| Friday, June 2 |
| » Lost to Athletics (20-24), 6-4 | Comiskey Park I (12-5) | 25-16 | |
| » W: Lew Krausse (3-7) L: Hoyt Wilhelm (2-1) S: Tony Pierce (2) | Second | 1 out |
| Saturday, June 3 |
| » Lost to Athletics (21-24), 3-1 | Comiskey Park I (12-6) | 25-17 | Lost 2 |
| » W: Chuck Dobson (2-2) L: Gary Peters (6-3) | Second | 1 out |
| Sunday, June 4 |
| » Defeated Athletics (21-25), 2-0 | Comiskey Park I (13-6) | 26-17 | |
| » W: Tommy John (4-3) L: Catfish Hunter (4-4) | Second | 1 out |
| » Lost to Athletics (22-25), 5-4 | Comiskey Park I (13-7) | 26-18 | |
| » W: Jim Nash (6-5) L: John Buzhardt (2-4) S: Tony Pierce (3) | Second | 1 out |
| Tuesday, June 6 |
| » Defeated Red Sox (24-23), 5-3 | Comiskey Park I (14-7) | 27-18 | |
| » W: Hoyt Wilhelm (3-1) L: Bucky Brandon (2-6) S: Wilbur Wood (1) | Second | 2 out |
| Thursday, June 8 |
| » Defeated Red Sox (24-24), 5-2 | Comiskey Park I (15-7) | 28-18 | Won 2 |
| » W: Joe Horlen (7-0) L: Dennis Bennett (4-2) | Second | 1½ out |
| » Lost to Red Sox (25-24), 7-3 | Comiskey Park I (15-8) | 28-19 | |
| » W: Gary Bell (2-5) L: Bruce Howard (1-4) | Second | 1½ out |
| Friday, June 9 |
| » Lost to Yankees (25-25), 2-1 | Yankee Stadium (1-2) | 28-20 | Lost 2 |
| » W: Steve Hamilton (2-1) L: Bob Locker (1-2) | Second | 1½ out |
| Saturday, June 10 |
| » Defeated Yankees (25-26), 9-0 | Yankee Stadium (2-2) | 29-20 | |
| » W: Gary Peters (7-3) L: Thad Tillotson (3-1) | Second | 1½ out |
| Sunday, June 11 |
| » Defeated Yankees (25-27), 2-1 | Yankee Stadium (3-2) | 30-20 | Won 2 |
| » W: Jim O'Toole (3-1) L: Mel Stottlemyre (5-6) S: Wilbur Wood (2) | First | -- |
| » Defeated Yankees (25-28), 3-2 | Yankee Stadium (4-2) | 31-20 | Won 3 |
| » W: Bruce Howard (2-4) L: Fritz Peterson (0-5) S: Bob Locker (8) | First | -- |
| Monday, June 12 |
| » Lost to Senators (24-32), 6-5 | Robert F. Kennedy Stadium (2-3) | 31-21 | |
| » W: Bob Humphreys (2-1) L: John Buzhardt (2-5) | First | -- |
| Tuesday, June 13 |
| » Defeated Senators (24-33), 6-0 | Robert F. Kennedy Stadium (3-3) | 32-21 | |
| » W: Tommy John (5-3) L: Barry Moore (3-3) | First | -- |
| Wednesday, June 14 |
| » Defeated Red Sox (28-28), 8-7 | Fenway Park (2-1) | 33-21 | Won 2 |
| » W: Gary Peters (8-3) L: Dennis Bennett (4-3) S: Wilbur Wood (3) | First | -- |
| » Lost to Red Sox (29-28), 6-1 | Fenway Park (2-2) | 33-22 | |
| » W: Lee Stange (1-4) L: Fred Klages (0-1) | First | -- |
| Thursday, June 15 |
| » Lost to Red Sox (30-28), 2-1 | Fenway Park (2-3) | 33-23 | Lost 2 |
| » W: John Wyatt (4-2) L: John Buzhardt (2-6) | First | -- |
| Saturday, June 17 |
| » Defeated Yankees (28-31), 1-0 | Comiskey Park I (16-8) | 34-23 | |
| » W: Joe Horlen (8-0) L: Fritz Peterson (0-6) S: Hoyt Wilhelm (3) | First | -- |
| Sunday, June 18 |
| » Defeated Yankees (28-32), 7-3 | Comiskey Park I (17-8) | 35-23 | Won 2 |
| » W: Gary Peters (9-3) L: Al Downing (7-4) | First | -- |
| » Defeated Yankees (28-33), 4-0 | Comiskey Park I (18-8) | 36-23 | Won 3 |
| » W: Tommy John (6-3) L: Fred Talbot (3-3) | First | -- |
| Tuesday, June 20 |
| » Lost to Senators (29-36), 4-2 | Comiskey Park I (18-9) | 36-24 | |
| » W: Frank Bertaina (2-2) L: Bruce Howard (2-5) S: Darold Knowles (4) | First | -- |
| Wednesday, June 21 |
| » Defeated Senators (29-37), 5-2 | Comiskey Park I (19-9) | 37-24 | |
| » W: Bruce Howard (3-5) L: Joe Coleman (3-5) S: Hoyt Wilhelm (4) | First | -- |
| » Defeated Senators (29-38), 2-1 | Comiskey Park I (20-9) | 38-24 | Won 2 |
| » W: Jim O'Toole (4-1) L: Barry Moore (3-5) S: Bob Locker (9) | First | -- |
| Friday, June 23 |
| » Lost to Twins (33-32), 1-0 | Metropolitan Stadium (2-2) | 38-25 | |
| » W: Dean Chance (10-5) L: Joe Horlen (8-1) | First | -- |
| Saturday, June 24 |
| » Defeated Twins (33-33), 5-2 | Metropolitan Stadium (3-2) | 39-25 | |
| » W: Gary Peters (10-3) L: Dave Boswell (4-5) | First | -- |
| Sunday, June 25 |
| » Lost to Twins (34-33), 3-1 | Metropolitan Stadium (3-3) | 39-26 | |
| » W: Jim Merritt (5-0) L: Tommy John (6-4) S: Al Worthington (9) | First | -- |
| Monday, June 26 |
| » Defeated Orioles (32-35), 5-4 | Memorial Stadium (3-0) | 40-26 | |
| » W: Bob Locker (2-2) L: Stu Miller (1-6) S: Hoyt Wilhelm (5) | First | -- |
| Tuesday, June 27 |
| » Defeated Orioles (32-36), 5-0 | Memorial Stadium (4-0) | 41-26 | Won 2 |
| » W: Joe Horlen (9-1) L: Steve Barber (4-8) | First | -- |
| Wednesday, June 28 |
| » Defeated Orioles (32-37), 3-2 | Memorial Stadium (5-0) | 42-26 | Won 3 |
| » W: Bob Locker (3-2) L: Bill Dillman (4-3) S: Hoyt Wilhelm (6) | First | -- |
| Future White Sox Matt Karchner is born in Berwick, PA. |
| Thursday, June 29 |
| » Lost to Orioles (33-37), 4-1 | Memorial Stadium (5-1) | 42-27 | |
| » W: Tom Phoebus (7-3) L: Jim O'Toole (4-2) | First | -- |
| Friday, June 30 |
| » Lost to Tigers (38-33), 4-1 | Tiger Stadium (0-3) | 42-28 | Lost 2 |
| » W: Johnny Podres (2-0) L: Tommy John (6-5) S: Mike Marshall (1) | First | -- |
| Saturday, July 1 |
| » Defeated Tigers (38-34), 6-5 | Tiger Stadium (1-3) | 43-28 | |
| » W: Joe Horlen (10-1) L: Dave Wickersham (4-1) S: Hoyt Wilhelm (7) | First | -- |
| Sunday, July 2 |
| » Lost to Tigers (39-34), 3-0 | Tiger Stadium (1-4) | 43-29 | |
| » W: Joe Sparma (9-1) L: Gary Peters (10-4) | First | -- |
| Monday, July 3 |
| » Lost to Orioles (36-39), 1-0 | Comiskey Park I (20-10) | 43-30 | Lost 2 |
| » W: Moe Drabowsky (6-0) L: John Buzhardt (2-7) | First | -- |
| Tuesday, July 4 |
| » Defeated Orioles (36-40), 4-0 | Comiskey Park I (21-10) | 44-30 | |
| » W: Tommy John (7-5) L: Pete Richert (4-9) | First | -- |
| Wednesday, July 5 |
| » Defeated Orioles (36-41), 3-2 | Comiskey Park I (22-10) | 45-30 | Won 2 |
| » W: Bob Locker (4-2) L: Stu Miller (1-7) | First | -- |
| » Major-league debuts: Curt Motton (Orioles) |
| Thursday, July 6 |
| » Lost to Orioles (37-41), 3-1 | Comiskey Park I (22-11) | 45-31 | |
| » W: Dave McNally (5-5) L: Jim O'Toole (4-3) | First | -- |
| Friday, July 7 |
| » Defeated Twins (43-35), 2-1 | Comiskey Park I (23-11) | 46-31 | |
| » W: Hoyt Wilhelm (4-1) L: Dean Chance (11-7) | First | -- |
| Saturday, July 8 |
| » Defeated Twins (43-36), 1-0 | Comiskey Park I (24-11) | 47-31 | Won 2 |
| » W: Tommy John (8-5) L: Jim Merritt (6-1) | First | -- |
| Sunday, July 9 |
| » Lost to Twins (44-36), 7-4 | Comiskey Park I (24-12) | 47-32 | |
| » W: Jim Kaat (8-8) L: Joe Horlen (10-2) S: Ron Kline (4) | First | -- |
| » Lost to Twins (45-36), 5-1 | Comiskey Park I (24-13) | 47-33 | Lost 2 |
| » W: Dave Boswell (7-5) L: Bruce Howard (3-6) S: Al Worthington (11) | First | -- |
| Wednesday, July 12 |
| » Lost to Indians (41-42), 5-3 | Cleveland Stadium (2-1) | 47-34 | Lost 3 |
| » W: Sam McDowell (6-7) L: Tommy John (8-6) | First | -- |
| Thursday, July 13 |
| » Defeated Angels (45-41), 1-0 | Comiskey Park I (25-13) | 48-34 | |
| » W: Gary Peters (11-4) L: George Brunet (7-12) S: Hoyt Wilhelm (8) | First | -- |
| Former White Sox Art Shires dies in Italy, TX at the age of 60. |
| Friday, July 14 |
| » Lost to Angels (46-41), 3-2 | Comiskey Park I (25-14) | 48-35 | |
| » W: Rickey Clark (7-6) L: Tommy John (8-7) S: Minnie Rojas (14) | First | -- |
| » Defeated Angels (46-42), 8-0 | Comiskey Park I (26-14) | 49-35 | |
| » W: Joe Horlen (11-2) L: Clyde Wright (3-3) | First | -- |
| Future White Sox Robin Ventura is born in Santa Maria, CA. |
| Saturday, July 15 |
| » Lost to Angels (47-42), 4-1 | Comiskey Park I (26-15) | 49-36 | |
| » W: Jack Hamilton (5-1) L: Bruce Howard (3-7) S: Minnie Rojas (15) | First | -- |
| Sunday, July 16 |
| » Defeated Athletics (36-52), 5-1 | Comiskey Park I (27-15) | 50-36 | |
| » W: Wilbur Wood (1-0) L: Catfish Hunter (8-8) | First | -- |
| » Lost to Athletics (37-52), 7-0 | Comiskey Park I (27-16) | 50-37 | |
| » W: Paul Lindblad (5-3) L: Aurelio Monteagudo (0-1) | First | -- |
| Tuesday, July 18 |
| » Lost to Angels (49-44), 6-3 | Anaheim Stadium (2-3) | 50-38 | Lost 2 |
| » W: Rickey Clark (8-6) L: Gary Peters (11-5) S: Bill Kelso (4) | First | -- |
| Wednesday, July 19 |
| » Lost to Angels (50-44), 5-2 | Anaheim Stadium (2-4) | 50-39 | Lost 3 |
| » W: Jack Hamilton (6-1) L: Joe Horlen (11-3) S: Minnie Rojas (16) | First | -- |
| Friday, July 21 |
| » Defeated Athletics (39-53), 5-4 | Municipal Stadium (2-2) | 51-39 | |
| » W: Wilbur Wood (2-0) L: Catfish Hunter (8-9) S: Bob Locker (10) | First | -- |
| Saturday, July 22 |
| » Lost to Athletics (40-53), 9-3 | Municipal Stadium (2-3) | 51-40 | |
| » W: Lew Krausse (5-12) L: John Buzhardt (2-8) | First | -- |
| Sunday, July 23 |
| » Defeated Athletics (40-54), 8-4 | Municipal Stadium (3-3) | 52-40 | |
| » W: Joe Horlen (12-3) L: Paul Lindblad (5-4) S: Bob Locker (11) | First | -- |
| » Defeated Athletics (40-55), 1-0 | Municipal Stadium (4-3) | 53-40 | Won 2 |
| » W: Gary Peters (12-5) L: Jim Nash (10-10) S: Hoyt Wilhelm (9) | First | -- |
| Tuesday, July 25 |
| » Defeated Indians (44-52), 3-1 | Comiskey Park I (28-16) | 54-40 | Won 3 |
| » W: Hoyt Wilhelm (5-1) L: Sam McDowell (7-9) | First | -- |
| » Defeated Indians (44-53), 6-5 | Comiskey Park I (29-16) | 55-40 | Won 4 |
| » W: John Buzhardt (3-8) L: Steve Bailey (2-4) | First | -- |
| Friday, July 28 |
| » Lost to Tigers (52-43), 7-4 | Comiskey Park I (29-17) | 55-41 | |
| » W: Earl Wilson (13-8) L: Gary Peters (12-6) S: Mike Marshall (6) | First | -- |
| Saturday, July 29 |
| » Defeated Tigers (52-44), 4-3 | Comiskey Park I (30-17) | 56-41 | |
| » W: Wilbur Wood (3-0) L: Joe Sparma (10-4) S: Don McMahon (3) | First | -- |
| Sunday, July 30 |
| » Defeated Tigers (52-45), 4-1 | Comiskey Park I (31-17) | 57-41 | Won 2 |
| » W: Joe Horlen (13-3) L: Denny McLain (12-12) | First | -- |
| » Lost to Tigers (53-45), 7-1 | Comiskey Park I (31-18) | 57-42 | |
| » W: Johnny Podres (3-0) L: Bruce Howard (3-8) | First | -- |
| Monday, July 31 |
| » Defeated Indians (46-56), 4-2 | Cleveland Stadium (3-1) | 58-42 | |
| » W: Bob Locker (5-2) L: Luis Tiant (7-7) | First | -- |
| Tuesday, August 1 |
| » Defeated Indians (46-57), 11-5 | Cleveland Stadium (4-1) | 59-42 | Won 2 |
| » W: Hoyt Wilhelm (6-1) L: Bob Allen (0-4) | First | -- |
| Wednesday, August 2 |
| » Lost to Indians (47-57), 5-1 | Cleveland Stadium (4-2) | 59-43 | |
| » W: Steve Hargan (11-8) L: Wilbur Wood (3-1) | First | -- |
| Sunday, August 6 |
| » Lost to Orioles (47-57), 5-2 | Memorial Stadium (5-2) | 59-44 | Lost 2 |
| » W: Wally Bunker (3-4) L: Bruce Howard (3-9) S: Moe Drabowsky (8) | First | -- |
| » Lost to Orioles (48-57), 4-0 | Memorial Stadium (5-3) | 59-45 | Lost 3 |
| » W: Tom Phoebus (9-7) L: Wilbur Wood (3-2) | First | -- |
| Tuesday, August 8 |
| » Lost to Tigers (58-49), 2-1 | Tiger Stadium (1-5) | 59-46 | Lost 4 |
| » W: Denny McLain (14-12) L: Hoyt Wilhelm (6-2) | First | -- |
| » Defeated Tigers (58-50), 6-4 | Tiger Stadium (2-5) | 60-46 | |
| » W: Don McMahon (2-2) L: Dave Wickersham (4-3) S: Wilbur Wood (4) | First | -- |
| » Major-league debuts: Rich Morales (White Sox) |
| Wednesday, August 9 |
| » Lost to Tigers (59-50), 4-2 | Tiger Stadium (2-6) | 60-47 | |
| » W: Earl Wilson (15-9) L: Fred Klages (0-2) | First | -- |
| Thursday, August 10 |
| » Defeated Tigers (59-51), 2-1 | Tiger Stadium (3-6) | 61-47 | |
| » W: Hoyt Wilhelm (7-2) L: Mike Marshall (1-2) S: Bob Locker (12) | First | -- |
| Friday, August 11 |
| » Lost to Twins (60-50), 3-2 | Metropolitan Stadium (3-4) | 61-48 | |
| » W: Dean Chance (15-8) L: John Buzhardt (3-9) | First | -- |
| Saturday, August 12 |
| » Lost to Twins (61-50), 6-2 | Metropolitan Stadium (3-5) | 61-49 | Lost 2 |
| » W: Jim Kaat (9-11) L: Hoyt Wilhelm (7-3) | First | -- |
| Sunday, August 13 |
| » Lost to Twins (62-50), 3-2 | Metropolitan Stadium (3-6) | 61-50 | Lost 3 |
| » W: Jim Merritt (9-3) L: Bob Locker (5-3) | Second | ½ out |
| Monday, August 14 |
| » Major-league debuts: Moose Stubing (Angels) |
| Tuesday, August 15 |
| » Defeated Athletics (50-67), 4-2 | Comiskey Park I (32-18) | 62-50 | |
| » W: Fred Klages (1-2) L: Jim Nash (10-12) S: Don McMahon (4) | Second | 1½ out |
| » Lost to Athletics (51-67), 4-2 | Comiskey Park I (32-19) | 62-51 | |
| » W: Chuck Dobson (8-6) L: Steve Jones (0-1) S: Lew Krausse (3) | Second | 1½ out |
| » Major-league debuts: Steve Jones (White Sox) |
| Wednesday, August 16 |
| » Defeated Athletics (51-68), 14-1 | Comiskey Park I (33-19) | 63-51 | |
| » W: Gary Peters (13-6) L: Blue Moon Odom (3-5) | Second | 1½ out |
| Friday, August 18 |
| » Defeated Orioles (53-65), 3-1 | Comiskey Park I (34-19) | 64-51 | Won 2 |
| » W: Joe Horlen (14-3) L: Moe Drabowsky (7-3) S: Hoyt Wilhelm (10) | Second | 1½ out |
| » Lost to Orioles (54-65), 8-2 | Comiskey Park I (34-20) | 64-52 | |
| » W: Jim Hardin (2-1) L: Bruce Howard (3-10) | Second | 1½ out |
| Sunday, August 20 |
| » Defeated Orioles (54-66), 4-2 | Comiskey Park I (35-20) | 65-52 | |
| » W: Gary Peters (14-6) L: Tom Phoebus (11-8) S: Bob Locker (13) | Second | ½ out |
| » Defeated Orioles (54-67), 2-1 | Comiskey Park I (36-20) | 66-52 | Won 2 |
| » W: Don McMahon (3-2) L: Wally Bunker (3-5) | Second | ½ out |
| Monday, August 21 |
| » Defeated Yankees (53-68), 4-3 | Comiskey Park I (37-20) | 67-52 | Won 3 |
| » W: Steve Jones (1-1) L: Al Downing (12-7) S: Hoyt Wilhelm (11) | First | -- |
| Tuesday, August 22 |
| » Defeated Yankees (53-69), 3-2 | Comiskey Park I (38-20) | 68-52 | Won 4 |
| » W: Wilbur Wood (4-2) L: Steve Barber (9-14) S: Don McMahon (5) | First | -- |
| » Lost to Yankees (54-69), 2-1 | Comiskey Park I (38-21) | 68-53 | |
| » W: Fritz Peterson (4-13) L: Joe Horlen (14-4) | First | -- |
| Wednesday, August 23 |
| » Defeated Yankees (54-70), 5-2 | Comiskey Park I (39-21) | 69-53 | |
| » W: Fred Klages (2-2) L: Fred Talbot (5-6) S: Bob Locker (14) | First | -- |
| Thursday, August 24 |
| » Lost to Yankees (55-70), 5-0 | Comiskey Park I (39-22) | 69-54 | |
| » W: Bill Monbouquette (3-3) L: Tommy John (8-8) | First | -- |
| Friday, August 25 |
| » Lost to Red Sox (71-55), 7-1 | Comiskey Park I (39-23) | 69-55 | Lost 2 |
| » W: Jim Lonborg (17-6) L: Gary Peters (14-7) | Second | ½ out |
| » Defeated Red Sox (71-56), 2-1 | Comiskey Park I (40-23) | 70-55 | |
| » W: Bob Locker (6-3) L: John Wyatt (7-6) | Second | ½ out |
| » Major-league debuts: Cisco Carlos (White Sox) |
| Saturday, August 26 |
| » Lost to Red Sox (72-56), 6-2 | Comiskey Park I (40-24) | 70-56 | |
| » W: Jerry Stephenson (2-0) L: Joe Horlen (14-5) S: Bucky Brandon (3) | Third | 1 out |
| Sunday, August 27 |
| » Lost to Red Sox (73-56), 4-3 | Comiskey Park I (40-25) | 70-57 | Lost 2 |
| » W: Gary Bell (10-10) L: Fred Klages (2-3) S: John Wyatt (17) | Third | 1 out |
| » Defeated Red Sox (73-57), 1-0 | Comiskey Park I (41-25) | 71-57 | |
| » W: Gary Peters (15-7) L: Bucky Brandon (5-10) | Third | 1 out |
| Monday, August 28 |
| » Lost to Senators (62-69), 2-1 | Robert F. Kennedy Stadium (3-4) | 71-58 | |
| » W: Bob Priddy (3-5) L: Joe Horlen (14-6) S: Dave Baldwin (11) | Fourth | 2 out |
| Future White Sox Darren Lewis is born in Berkeley, CA. |
| Tuesday, August 29 |
| » Lost to Senators (63-69), 3-0 | Robert F. Kennedy Stadium (3-5) | 71-59 | Lost 2 |
| » W: Dick Bosman (1-0) L: Tommy John (8-9) | Fourth | 2½ out |
| Wednesday, August 30 |
| » Defeated Senators (63-70), 5-1 | Robert F. Kennedy Stadium (4-5) | 72-59 | |
| » W: Fred Klages (3-3) L: Camilo Pascual (11-10) S: Bob Locker (15) | Fourth | 2½ out |
| Thursday, August 31 |
| » Defeated Red Sox (76-59), 4-2 | Fenway Park (3-3) | 73-59 | Won 2 |
| » W: Don McMahon (4-2) L: Gary Bell (10-11) | Fourth | 1½ out |
| Friday, September 1 |
| » Lost to Red Sox (77-59), 10-2 | Fenway Park (3-4) | 73-60 | |
| » W: Jose Santiago (8-4) L: Gary Peters (15-8) | Fourth | 2½ out |
| » Major-league debuts: Ed Herrmann and Cotton Nash (White Sox) |
| Saturday, September 2 |
| » Defeated Red Sox (77-60), 4-1 | Fenway Park (4-4) | 74-60 | |
| » W: Joe Horlen (15-6) L: Jim Lonborg (18-7) | Third | 2 out |
| Sunday, September 3 |
| » Defeated Red Sox (77-61), 4-0 | Fenway Park (5-4) | 75-60 | Won 2 |
| » W: Tommy John (9-9) L: Lee Stange (8-9) | Third | 1 out |
| Monday, September 4 |
| » Lost to Yankees (62-76), 3-2 | Yankee Stadium (4-3) | 75-61 | |
| » W: Al Downing (13-8) L: Gary Peters (15-9) S: Dooley Womack (13) | Third | 1 out |
| » Defeated Yankees (62-77), 3-2 | Yankee Stadium (5-3) | 76-61 | |
| » W: Hoyt Wilhelm (8-3) L: Fred Talbot (5-8) | Third | 1 out |
| Tuesday, September 5 |
| » Defeated Yankees (62-78), 5-3 | Yankee Stadium (6-3) | 77-61 | Won 2 |
| » W: Steve Jones (2-1) L: Joe Verbanic (4-3) S: Bob Locker (16) | Third | 1 out |
| » Major-league debuts: Jerry Kenney (Yankees) |
| Wednesday, September 6 |
| » Defeated Angels (72-67), 3-2 | Comiskey Park I (42-25) | 78-61 | Won 3 |
| » W: Fred Klages (4-3) L: Pete Cimino (3-3) | First | -- |
| Friday, September 8 |
| » Lost to Tigers (80-62), 4-1 | Comiskey Park I (42-26) | 78-62 | |
| » W: Mickey Lolich (10-12) L: Tommy John (9-10) S: Fred Lasher (6) | Third | 1 out |
| Saturday, September 9 |
| » Lost to Tigers (81-62), 7-3 | Comiskey Park I (42-27) | 78-63 | Lost 2 |
| » W: Pat Dobson (1-2) L: Bob Locker (6-4) | Third | 2 out |
| » Major-league debuts: Roger Nelson (White Sox) |
| Sunday, September 10 |
| » Defeated Tigers (81-63), 6-0 | Comiskey Park I (43-27) | 79-63 | |
| » W: Joe Horlen (16-6) L: Joe Sparma (14-9) | Fourth | 1½ out |
| » Defeated Tigers (81-64), 4-0 | Comiskey Park I (44-27) | 80-63 | Won 2 |
| » W: Cisco Carlos (1-0) L: Denny McLain (17-16) S: Bob Locker (17) | Fourth | 1½ out |
| Monday, September 11 |
| » Lost to Orioles (64-79), 6-1 | Comiskey Park I (44-28) | 80-64 | |
| » W: Jim Hardin (6-2) L: Fred Klages (4-4) | Fourth | 2½ out |
| Tuesday, September 12 |
| » Lost to Indians (68-78), 4-3 | Comiskey Park I (44-29) | 80-65 | Lost 2 |
| » W: Sam McDowell (12-13) L: Steve Jones (2-2) S: Orlando Pena (5) | Third | 3 out |
| » Lost to Indians (69-78), 7-1 | Comiskey Park I (44-30) | 80-66 | Lost 3 |
| » W: Luis Tiant (10-9) L: Tommy John (9-11) | Third | 3 out |
| Former White Sox Rollie Zeider dies in Garrett, IN at the age of 84. |
| Wednesday, September 13 |
| » Defeated Indians (69-79), 1-0 | Comiskey Park I (45-30) | 81-66 | |
| » W: Don McMahon (5-2) L: Bobby Tiefenauer (0-1) | Third | 3 out |
| Thursday, September 14 |
| » Defeated Indians (69-80), 4-0 | Comiskey Park I (46-30) | 82-66 | Won 2 |
| » W: Cisco Carlos (2-0) L: Orlando Pena (0-4) | Third | 2½ out |
| Friday, September 15 |
| » Defeated Twins (84-64), 7-3 | Comiskey Park I (47-30) | 83-66 | Won 3 |
| » W: Joe Horlen (17-6) L: Dave Boswell (13-11) | Second | 1½ out |
| Saturday, September 16 |
| » Defeated Twins (84-65), 5-4 | Comiskey Park I (48-30) | 84-66 | Won 4 |