| Thursday, March 9 |
| Future Twin Vince Horsman is born in Halifax, NS. |
| Sunday, March 26 |
| Future Twin Jarvis Brown is born in Waukegan, IL. |
| Tuesday, April 11 |
| » Lost to Orioles (1-0), 6-3 | Memorial Stadium (0-1) | 0-1 | |
| » W: Moe Drabowsky (1-0) L: Jim Kaat (0-1) S: Stu Miller (1) | Third | 1 out |
| » Major-league debuts: Rod Carew (Twins) |
| Thursday, April 13 |
| » Lost to Orioles (2-0), 7-1 | Memorial Stadium (0-2) | 0-2 | Lost 2 |
| » W: Jim Palmer (1-0) L: Dean Chance (0-1) | Fifth | 2 out |
| Friday, April 14 |
| » Defeated Tigers (1-2), 5-3 | Metropolitan Stadium (1-0) | 1-2 | |
| » W: Jim Merritt (1-0) L: Earl Wilson (0-1) | Fourth | 2 out |
| Future Twin Mike Trombley is born in Springfield, MA. |
| Saturday, April 15 |
| » Lost to Tigers (2-2), 4-3 | Metropolitan Stadium (1-1) | 1-3 | |
| » W: Dave Wickersham (1-0) L: Jim Kaat (0-2) S: Fred Gladding (1) | Fifth | 2 out |
| Sunday, April 16 |
| » Lost to Indians (2-2), 4-3 | Metropolitan Stadium (1-2) | 1-4 | Lost 2 |
| » W: Sam McDowell (1-0) L: Mudcat Grant (0-1) S: Bob Allen (1) | Sixth | 2½ out |
| Wednesday, April 19 |
| » Defeated Orioles (4-3), 3-2 | Metropolitan Stadium (2-2) | 2-4 | |
| » W: Dean Chance (1-1) L: Stu Miller (0-2) | Seventh | 2 out |
| Thursday, April 20 |
| Future Twin Greg Brummett is born in Wichita, KS. |
| Friday, April 21 |
| » Lost to Tigers (6-3), 12-4 | Tiger Stadium (0-1) | 2-5 | |
| » W: Denny McLain (2-1) L: Dave Boswell (0-1) | Seventh | 3 out |
| Saturday, April 22 |
| » Defeated Tigers (6-4), 4-3 | Tiger Stadium (1-1) | 3-5 | |
| » W: Jim Kaat (1-2) L: Mickey Lolich (1-1) S: Al Worthington (1) | Sixth | 2 out |
| Sunday, April 23 |
| » Defeated Tigers (6-5), 4-2 | Tiger Stadium (2-1) | 4-5 | Won 2 |
| » W: Al Worthington (1-0) L: Earl Wilson (1-2) | Fifth | 1½ out |
| Tuesday, April 25 |
| » Lost to Indians (5-6), 1-0 | Cleveland Stadium (0-1) | 4-6 | |
| » W: Steve Hargan (2-1) L: Mudcat Grant (0-2) | Eighth | 2 out |
| Thursday, April 27 |
| » Lost to Indians (6-6), 5-4 | Cleveland Stadium (0-2) | 4-7 | Lost 2 |
| » W: Sam McDowell (2-0) L: Al Worthington (1-1) S: George Culver (1) | Sixth | 2½ out |
| Friday, April 28 |
| » Defeated Senators (4-8), 7-3 | Robert F. Kennedy Stadium (1-0) | 5-7 | |
| » W: Dean Chance (2-1) L: Joe Coleman (2-1) | Seventh | 2½ out |
| Saturday, April 29 |
| » Lost to Senators (5-8), 9-6 | Robert F. Kennedy Stadium (1-1) | 5-8 | |
| » W: Darold Knowles (2-1) L: Jim Perry (0-1) | Fifth | 3 out |
| Sunday, April 30 |
| » Lost to Senators (6-8), 7-3 | Robert F. Kennedy Stadium (1-2) | 5-9 | Lost 2 |
| » W: Camilo Pascual (1-0) L: Mudcat Grant (0-3) S: Bob Humphreys (1) | Ninth | 4½ out |
| » Lost to Senators (7-8), 3-0 | Robert F. Kennedy Stadium (1-3) | 5-10 | Lost 3 |
| » W: Barry Moore (2-0) L: Jim Kaat (1-3) | Ninth | 4½ out |
| Tuesday, May 2 |
| » Defeated Yankees (9-7), 13-4 | Metropolitan Stadium (3-2) | 6-10 | |
| » W: Dean Chance (3-1) L: Fritz Peterson (0-2) S: Al Worthington (2) | Eighth | 4 out |
| Wednesday, May 3 |
| » Defeated Yankees (9-8), 4-3 | Metropolitan Stadium (4-2) | 7-10 | Won 2 |
| » W: Ron Kline (1-0) L: Hal Reniff (0-1) | Sixth | 3 out |
| Friday, May 5 |
| » Defeated Red Sox (9-9), 5-2 | Metropolitan Stadium (5-2) | 8-10 | Won 3 |
| » W: Mudcat Grant (1-3) L: Billy Rohr (2-1) S: Al Worthington (3) | Seventh | 3 out |
| Saturday, May 6 |
| » Defeated Red Sox (9-10), 4-2 | Metropolitan Stadium (6-2) | 9-10 | Won 4 |
| » W: Dean Chance (4-1) L: Bucky Brandon (0-3) | Fourth | 3 out |
| Sunday, May 7 |
| » Lost to Red Sox (10-10), 9-6 | Metropolitan Stadium (6-3) | 9-11 | |
| » W: Dan Osinski (1-0) L: Jim Perry (0-2) S: John Wyatt (1) | Seventh | 4 out |
| Monday, May 8 |
| » Lost to Senators (12-10), 7-4 | Metropolitan Stadium (6-4) | 9-12 | Lost 2 |
| » W: Jim Hannan (1-1) L: Al Worthington (1-2) S: Dave Baldwin (1) | Sixth | 4½ out |
| Tuesday, May 9 |
| » Defeated Senators (12-11), 11-1 | Metropolitan Stadium (7-4) | 10-12 | |
| » W: Mudcat Grant (2-3) L: Joe Coleman (2-2) | Seventh | 4½ out |
| Thursday, May 11 |
| » Defeated Athletics (10-14), 8-0 | Metropolitan Stadium (8-4) | 11-12 | Won 2 |
| » W: Dean Chance (5-1) L: Catfish Hunter (3-3) | Sixth | 4½ out |
| Friday, May 12 |
| » Lost to Athletics (11-14), 2-1 | Metropolitan Stadium (8-5) | 11-13 | |
| » W: Jim Nash (4-2) L: Jim Kaat (1-4) | Sixth | 5½ out |
| Saturday, May 13 |
| » Lost to Athletics (12-14), 5-2 | Metropolitan Stadium (8-6) | 11-14 | Lost 2 |
| » W: Lew Krausse (2-4) L: Mudcat Grant (2-4) S: Paul Lindblad (2) | Sixth | 6½ out |
| Sunday, May 14 |
| » Lost to Athletics (13-14), 4-2 | Metropolitan Stadium (8-7) | 11-15 | Lost 3 |
| » W: Chuck Dobson (1-1) L: Jim Ollom (0-1) S: Jack Aker (5) | Seventh | 7½ out |
| Tuesday, May 16 |
| » Defeated White Sox (18-8), 1-0 | Comiskey Park I (1-0) | 12-15 | |
| » W: Dean Chance (6-1) L: John Buzhardt (1-2) | Seventh | 6½ out |
| Wednesday, May 17 |
| » Lost to White Sox (19-8), 5-4 | Comiskey Park I (1-1) | 12-16 | |
| » W: Joe Horlen (5-0) L: Jim Kaat (1-5) S: Bob Locker (7) | Seventh | 7½ out |
| Friday, May 19 |
| » Defeated Angels (14-20), 5-2 | Anaheim Stadium (1-0) | 13-16 | |
| » W: Mudcat Grant (3-4) L: George Brunet (1-7) S: Al Worthington (4) | Seventh | 7½ out |
| Saturday, May 20 |
| » Defeated Angels (14-21), 7-2 | Anaheim Stadium (2-0) | 14-16 | Won 2 |
| » W: Dean Chance (7-1) L: Nick Willhite (0-1) | Sixth | 6½ out |
| Sunday, May 21 |
| » Defeated Angels (14-22), 12-3 | Anaheim Stadium (3-0) | 15-16 | Won 3 |
| » W: Dave Boswell (1-1) L: Rickey Clark (2-3) | Fifth | 5½ out |
| Monday, May 22 |
| » Defeated White Sox (20-11), 8-7 | Metropolitan Stadium (9-7) | 16-16 | Won 4 |
| » W: Ron Kline (2-0) L: Bob Locker (1-1) S: Al Worthington (5) | Third | 5 out |
| Tuesday, May 23 |
| » Lost to White Sox (21-11), 5-4 | Metropolitan Stadium (9-8) | 16-17 | |
| » W: John Buzhardt (2-2) L: Mudcat Grant (3-5) S: Hoyt Wilhelm (1) | Sixth | 5½ out |
| Wednesday, May 24 |
| » Lost to White Sox (22-11), 14-1 | Metropolitan Stadium (9-9) | 16-18 | Lost 2 |
| » W: Gary Peters (6-1) L: Dean Chance (7-2) | Sixth | 6½ out |
| Thursday, May 25 |
| » Lost to Athletics (18-18), 3-2 | Municipal Stadium (0-1) | 16-19 | Lost 3 |
| » W: Paul Lindblad (3-0) L: Dave Boswell (1-2) | Sixth | 7 out |
| Friday, May 26 |
| » Defeated Athletics (18-19), 5-0 | Municipal Stadium (1-1) | 17-19 | |
| » W: Jim Merritt (2-0) L: Jim Nash (5-4) | Sixth | 6½ out |
| Saturday, May 27 |
| » Defeated Athletics (18-20), 4-1 | Municipal Stadium (2-1) | 18-19 | Won 2 |
| » W: Mudcat Grant (4-5) L: Lew Krausse (2-7) S: Al Worthington (6) | Fifth | 6½ out |
| Sunday, May 28 |
| » Defeated Athletics (18-21), 4-3 | Municipal Stadium (3-1) | 19-19 | Won 3 |
| » W: Dean Chance (8-2) L: Chuck Dobson (1-2) S: Al Worthington (7) | Fifth | 6 out |
| » Lost to Athletics (19-21), 7-2 | Municipal Stadium (3-2) | 19-20 | |
| » W: Blue Moon Odom (2-2) L: Jim Kaat (1-6) S: Paul Lindblad (3) | Fifth | 6 out |
| Tuesday, May 30 |
| » Lost to Yankees (17-21), 4-3 | Yankee Stadium (0-1) | 19-21 | Lost 2 |
| » W: Al Downing (5-3) L: Dave Boswell (1-3) S: Dooley Womack (2) | Sixth | 6½ out |
| » Defeated Yankees (17-22), 3-0 | Yankee Stadium (1-1) | 20-21 | |
| » W: Jim Merritt (3-0) L: Fritz Peterson (0-4) | Sixth | 6½ out |
| Wednesday, May 31 |
| » Lost to Red Sox (22-20), 3-2 | Fenway Park (0-1) | 20-22 | |
| » W: Bucky Brandon (2-5) L: Jim Perry (0-3) S: John Wyatt (5) | Sixth | 6½ out |
| Thursday, June 1 |
| » Defeated Red Sox (22-21), 4-0 | Fenway Park (1-1) | 21-22 | |
| » W: Dean Chance (9-2) L: Billy Rohr (2-3) | Sixth | 5½ out |
| Friday, June 2 |
| » Lost to Angels (19-28), 2-0 | Metropolitan Stadium (9-10) | 21-23 | |
| » W: Jim McGlothlin (5-1) L: Jim Kaat (1-7) | Sixth | 6½ out |
| Saturday, June 3 |
| » Defeated Angels (19-29), 8-6 | Metropolitan Stadium (10-10) | 22-23 | |
| » W: Dave Boswell (2-3) L: George Brunet (1-9) S: Ron Kline (1) | Sixth | 5½ out |
| Sunday, June 4 |
| » Defeated Angels (19-30), 8-7 | Metropolitan Stadium (11-10) | 23-23 | Won 2 |
| » W: Jim Perry (1-3) L: Minnie Rojas (3-4) | Sixth | 5 out |
| Monday, June 5 |
| » Defeated Indians (23-23), 5-4 | Metropolitan Stadium (12-10) | 24-23 | Won 3 |
| » W: Al Worthington (2-2) L: Steve Bailey (2-2) | Fifth | 5 out |
| Tuesday, June 6 |
| » Lost to Indians (24-23), 6-4 | Metropolitan Stadium (12-11) | 24-24 | |
| » W: Sonny Siebert (5-4) L: Jim Perry (1-4) S: Bob Allen (3) | Fifth | 6 out |
| » Defeated Indians (24-24), 7-1 | Metropolitan Stadium (13-11) | 25-24 | |
| » W: Dave Boswell (3-3) L: John O'Donoghue (1-1) | Fifth | 6 out |
| Thursday, June 8 |
| » Lost to Indians (25-24), 7-5 | Metropolitan Stadium (13-12) | 25-25 | |
| » W: George Culver (3-0) L: Al Worthington (2-3) | Fifth | 6 out |
| Friday, June 9 |
| » Lost to Orioles (26-23), 11-2 | Metropolitan Stadium (13-13) | 25-26 | Lost 2 |
| » Manager: Cal Ermer |
| » W: Moe Drabowsky (5-0) L: Dean Chance (9-3) | Sixth | 6 out |
| Saturday, June 10 |
| » Defeated Orioles (26-24), 8-1 | Metropolitan Stadium (14-13) | 26-26 | |
| » W: Jim Kaat (2-7) L: Tom Phoebus (5-2) | Fifth | 5 out |
| Sunday, June 11 |
| » Lost to Orioles (27-24), 5-2 | Metropolitan Stadium (14-14) | 26-27 | |
| » W: Bill Dillman (4-0) L: Dave Boswell (3-4) | Fifth | 5½ out |
| » Defeated Orioles (27-25), 10-7 | Metropolitan Stadium (15-14) | 27-27 | |
| » W: Jim Perry (2-4) L: Eddie Watt (0-3) S: Al Worthington (8) | Fifth | 5½ out |
| Monday, June 12 |
| » Defeated Tigers (31-23), 11-5 | Metropolitan Stadium (16-14) | 28-27 | Won 2 |
| » W: Jim Merritt (4-0) L: Mickey Lolich (5-8) | Fifth | 4½ out |
| Tuesday, June 13 |
| » Lost to Tigers (32-23), 15-10 | Metropolitan Stadium (16-15) | 28-28 | |
| » W: Denny McLain (7-7) L: Dean Chance (9-4) S: Dave Wickersham (2) | Fifth | 5½ out |
| Wednesday, June 14 |
| » Defeated Tigers (32-24), 7-0 | Metropolitan Stadium (17-15) | 29-28 | |
| » W: Jim Kaat (3-7) L: Earl Wilson (8-6) | Third | 5 out |
| Future Twin George Tsamis is born in Campbell, CA. |
| Thursday, June 15 |
| » Defeated Tigers (32-25), 6-4 | Metropolitan Stadium (18-15) | 30-28 | Won 2 |
| » W: Ron Kline (3-0) L: Fred Gladding (1-2) | Third | 4 out |
| Friday, June 16 |
| » Lost to Indians (29-30), 2-1 | Cleveland Stadium (0-3) | 30-29 | |
| » W: Luis Tiant (5-1) L: Al Worthington (2-4) | Third | 4½ out |
| Saturday, June 17 |
| » Lost to Indians (30-30), 7-3 | Cleveland Stadium (0-4) | 30-30 | Lost 2 |
| » W: John O'Donoghue (3-1) L: Dean Chance (9-5) S: Steve Bailey (1) | Fourth | 5½ out |
| Sunday, June 18 |
| » Defeated Indians (30-31), 4-2 | Cleveland Stadium (1-4) | 31-30 | |
| » W: Jim Kaat (4-7) L: Sam McDowell (3-5) S: Ron Kline (2) | Third | 6 out |
| Monday, June 19 |
| » Defeated Orioles (29-32), 4-0 | Memorial Stadium (1-2) | 32-30 | Won 2 |
| » W: Dave Boswell (4-4) L: Tom Phoebus (5-3) | Third | 6 out |
| » Lost to Orioles (30-32), 9-5 | Memorial Stadium (1-3) | 32-31 | |
| » W: Wally Bunker (2-3) L: Mudcat Grant (4-6) S: Bill Dillman (2) | Third | 6 out |
| Wednesday, June 21 |
| » Tied Tigers, 5-5 | Tiger Stadium (2-1) | 32-31 | |
| » Starters: Jim Merritt vs Earl Wilson | Fourth | 6½ out |
| Thursday, June 22 |
| » Lost to Tigers (36-28), 5-2 | Tiger Stadium (2-2) | 32-32 | Lost 2 |
| » W: Joe Sparma (7-1) L: Jim Kaat (4-8) | Fifth | 7 out |
| Friday, June 23 |
| » Defeated White Sox (38-25), 1-0 | Metropolitan Stadium (19-15) | 33-32 | |
| » W: Dean Chance (10-5) L: Joe Horlen (8-1) | Fourth | 6 out |
| Saturday, June 24 |
| » Lost to White Sox (39-25), 5-2 | Metropolitan Stadium (19-16) | 33-33 | |
| » W: Gary Peters (10-3) L: Dave Boswell (4-5) | Fifth | 7 out |
| Sunday, June 25 |
| » Defeated White Sox (39-26), 3-1 | Metropolitan Stadium (20-16) | 34-33 | |
| » W: Jim Merritt (5-0) L: Tommy John (6-4) S: Al Worthington (9) | Fourth | 6 out |
| Monday, June 26 |
| » Defeated Red Sox (35-33), 2-1 | Metropolitan Stadium (21-16) | 35-33 | Won 2 |
| » W: Jim Kaat (5-8) L: Jim Lonborg (9-3) S: Al Worthington (10) | Third | 6 out |
| Tuesday, June 27 |
| » Lost to Red Sox (36-33), 3-2 | Metropolitan Stadium (21-17) | 35-34 | |
| » W: Gary Waslewski (1-0) L: Dean Chance (10-6) S: John Wyatt (8) | Fourth | 7 out |
| Wednesday, June 28 |
| » Defeated Red Sox (36-34), 3-2 | Metropolitan Stadium (22-17) | 36-34 | |
| » W: Dave Boswell (5-5) L: Lee Stange (2-5) | Third | 7 out |
| Saturday, July 1 |
| » Defeated Senators (32-42), 4-0 | Metropolitan Stadium (23-17) | 37-34 | Won 2 |
| » W: Jim Kaat (6-8) L: Barry Moore (3-7) | Third | 6 out |
| Sunday, July 2 |
| » Defeated Senators (32-43), 4-1 | Metropolitan Stadium (24-17) | 38-34 | Won 3 |
| » W: Dean Chance (11-6) L: Camilo Pascual (7-5) | Second | 4½ out |
| » Defeated Senators (32-44), 6-1 | Metropolitan Stadium (25-17) | 39-34 | Won 4 |
| » W: Jim Merritt (6-0) L: Joe Coleman (4-6) | Second | 4½ out |
| Monday, July 3 |
| » Defeated Yankees (34-40), 3-0 | Metropolitan Stadium (26-17) | 40-34 | Won 5 |
| » W: Dave Boswell (6-5) L: Fritz Peterson (0-8) S: Ron Kline (3) | Second | 3½ out |
| Tuesday, July 4 |
| » Defeated Yankees (34-41), 8-3 | Metropolitan Stadium (27-17) | 41-34 | Won 6 |
| » W: Mudcat Grant (5-6) L: Joe Verbanic (3-2) | Second | 3 out |
| » Defeated Yankees (34-42), 7-6 | Metropolitan Stadium (28-17) | 42-34 | Won 7 |
| » W: Al Worthington (3-4) L: Steve Hamilton (2-2) | Second | 3 out |
| Wednesday, July 5 |
| » Defeated Yankees (34-43), 10-4 | Metropolitan Stadium (29-17) | 43-34 | Won 8 |
| » W: Jim Kaat (7-8) L: Cecil Perkins (0-1) | Second | 3 out |
| Friday, July 7 |
| » Lost to White Sox (46-31), 2-1 | Comiskey Park I (1-2) | 43-35 | |
| » W: Hoyt Wilhelm (4-1) L: Dean Chance (11-7) | Third | 3½ out |
| Saturday, July 8 |
| » Lost to White Sox (47-31), 1-0 | Comiskey Park I (1-3) | 43-36 | Lost 2 |
| » W: Tommy John (8-5) L: Jim Merritt (6-1) | Third | 4½ out |
| Sunday, July 9 |
| » Defeated White Sox (47-32), 7-4 | Comiskey Park I (2-3) | 44-36 | |
| » W: Jim Kaat (8-8) L: Joe Horlen (10-2) S: Ron Kline (4) | Third | 2½ out |
| » Defeated White Sox (47-33), 5-1 | Comiskey Park I (3-3) | 45-36 | Won 2 |
| » W: Dave Boswell (7-5) L: Bruce Howard (3-6) S: Al Worthington (11) | Third | 2½ out |
| Thursday, July 13 |
| » Defeated Athletics (35-50), 3-2 | Metropolitan Stadium (30-17) | 46-36 | Won 3 |
| » W: Al Worthington (4-4) L: Jim Nash (9-9) | Second | 2 out |
| Friday, July 14 |
| » Lost to Athletics (36-50), 3-2 | Metropolitan Stadium (30-18) | 46-37 | |
| » W: Chuck Dobson (5-6) L: Jim Kaat (8-9) S: Jack Aker (9) | Second | 2½ out |
| Saturday, July 15 |
| » Defeated Athletics (36-51), 3-2 | Metropolitan Stadium (31-18) | 47-37 | |
| » W: Ron Kline (4-0) L: Jack Aker (2-5) | Second | 1½ out |
| Sunday, July 16 |
| » Defeated Angels (47-43), 5-1 | Metropolitan Stadium (32-18) | 48-37 | Won 2 |
| » W: Dave Boswell (8-5) L: Bill Kelso (4-2) | Second | ½ out |
| » Defeated Angels (47-44), 7-6 | Metropolitan Stadium (33-18) | 49-37 | Won 3 |
| » W: Al Worthington (5-4) L: Ken Turner (1-2) | Second | ½ out |
| Monday, July 17 |
| » Lost to Angels (48-44), 2-0 | Metropolitan Stadium (33-19) | 49-38 | |
| » W: George Brunet (8-12) L: Jim Merritt (6-2) | Second | 1 out |
| Tuesday, July 18 |
| » Lost to Athletics (38-52), 5-2 | Municipal Stadium (3-3) | 49-39 | Lost 2 |
| » W: Jim Nash (10-9) L: Jim Kaat (8-10) S: Jack Aker (10) | Second | 1 out |
| Wednesday, July 19 |
| » Lost to Athletics (39-52), 9-6 | Municipal Stadium (3-4) | 49-40 | Lost 3 |
| » W: Jack Sanford (4-3) L: Al Worthington (5-5) S: Lew Krausse (1) | Second | 1 out |
| Friday, July 21 |
| » Lost to Angels (51-44), 2-1 | Anaheim Stadium (3-1) | 49-41 | Lost 4 |
| » W: George Brunet (9-12) L: Dave Boswell (8-6) S: Minnie Rojas (17) | Third | 2 out |
| Saturday, July 22 |
| » Lost to Angels (52-44), 2-1 | Anaheim Stadium (3-2) | 49-42 | Lost 5 |
| » W: Jim McGlothlin (9-2) L: Jim Merritt (6-3) S: Bill Kelso (5) | Fourth | 2 out |
| Sunday, July 23 |
| » Lost to Angels (53-44), 2-1 | Anaheim Stadium (3-3) | 49-43 | Lost 6 |
| » W: Jack Hamilton (7-1) L: Dean Chance (11-8) S: Minnie Rojas (18) | Fifth | 3½ out |
| Tuesday, July 25 |
| » Tied Yankees, 1-1 | Yankee Stadium (1-1) | 49-43 | |
| » Starters: Jim Kaat vs Al Downing | Fifth | 4½ out |
| Wednesday, July 26 |
| » Lost to Yankees (41-53), 6-1 | Yankee Stadium (1-2) | 49-44 | Lost 7 |
| » W: Steve Barber (6-11) L: Jim Perry (2-5) S: Steve Hamilton (3) | Fifth | 4½ out |
| » Defeated Yankees (41-54), 3-2 | Yankee Stadium (2-2) | 50-44 | |
| » W: Al Worthington (6-5) L: Thad Tillotson (3-7) S: Jim Roland (1) | Fifth | 4½ out |
| Thursday, July 27 |
| » Lost to Yankees (42-54), 6-2 | Yankee Stadium (2-3) | 50-45 | |
| » W: Mel Stottlemyre (9-10) L: Dave Boswell (8-7) | Fifth | 5 out |
| Friday, July 28 |
| » Defeated Red Sox (54-42), 9-2 | Fenway Park (2-1) | 51-45 | |
| » W: Dean Chance (12-8) L: Jim Lonborg (14-4) | Fifth | 4 out |
| Saturday, July 29 |
| » Lost to Red Sox (55-42), 6-3 | Fenway Park (2-2) | 51-46 | |
| » W: John Wyatt (5-4) L: Al Worthington (6-6) S: Jose Santiago (3) | Fourth | 4½ out |
| » Defeated Red Sox (55-43), 10-3 | Fenway Park (3-2) | 52-46 | |
| » W: Jim Perry (3-5) L: Gary Waslewski (2-2) | Fourth | 4½ out |
| Sunday, July 30 |
| » Defeated Red Sox (55-44), 7-5 | Fenway Park (4-2) | 53-46 | Won 2 |
| » W: Jim Merritt (7-3) L: Bucky Brandon (4-8) S: Jim Roland (2) | Fourth | 4 out |
| Monday, July 31 |
| » Lost to Red Sox (56-44), 4-0 | Fenway Park (4-3) | 53-47 | |
| » W: Lee Stange (7-6) L: Dave Boswell (8-8) | Fourth | 5 out |
| Tuesday, August 1 |
| » Defeated Senators (51-54), 5-4 | Robert F. Kennedy Stadium (2-3) | 54-47 | |
| » W: Dean Chance (13-8) L: Camilo Pascual (10-8) S: Al Worthington (12) | Fourth | 5 out |
| Wednesday, August 2 |
| » Lost to Senators (52-54), 5-4 | Robert F. Kennedy Stadium (2-4) | 54-48 | |
| » W: Casey Cox (5-1) L: Al Worthington (6-7) | Fourth | 5 out |
| Friday, August 4 |
| » Defeated Red Sox (58-47), 3-0 | Metropolitan Stadium (34-19) | 55-48 | |
| » W: Jim Merritt (8-3) L: Bucky Brandon (4-9) | Fourth | 4½ out |
| Saturday, August 5 |
| » Defeated Red Sox (58-48), 2-1 | Metropolitan Stadium (35-19) | 56-48 | Won 2 |
| » W: Dave Boswell (9-8) L: Lee Stange (7-7) | Third | 4 out |
| Sunday, August 6 |
| » Defeated Red Sox (58-49), 2-0 | Metropolitan Stadium (36-19) | 57-48 | Won 3 |
| » W: Dean Chance (14-8) L: Jim Lonborg (15-5) | Second | 2½ out |
| Monday, August 7 |
| » Lost to Senators (55-55), 5-0 | Metropolitan Stadium (36-20) | 57-49 | |
| » W: Phil Ortega (9-5) L: Jim Kaat (8-11) | Third | 3 out |
| Tuesday, August 8 |
| » Defeated Senators (55-56), 3-2 | Metropolitan Stadium (37-20) | 58-49 | |
| » W: Al Worthington (7-7) L: Dave Baldwin (0-3) | Second | 2½ out |
| Wednesday, August 9 |
| » Lost to Senators (56-56), 9-7 | Metropolitan Stadium (37-21) | 58-50 | |
| » W: Dave Baldwin (1-3) L: Jim Roland (0-1) | Fourth | 2½ out |
| » Major-league debuts: Hank Izquierdo (Twins) |
| Thursday, August 10 |
| » Defeated Senators (56-57), 5-0 | Metropolitan Stadium (38-21) | 59-50 | |
| » W: Jim Perry (4-5) L: Barry Moore (7-10) | Third | 2½ out |
| Friday, August 11 |
| » Defeated White Sox (61-48), 3-2 | Metropolitan Stadium (39-21) | 60-50 | Won 2 |
| » W: Dean Chance (15-8) L: John Buzhardt (3-9) | Second | 1½ out |
| Saturday, August 12 |
| » Defeated White Sox (61-49), 6-2 | Metropolitan Stadium (40-21) | 61-50 | Won 3 |
| » W: Jim Kaat (9-11) L: Hoyt Wilhelm (7-3) | Second | ½ out |
| Sunday, August 13 |
| » Defeated White Sox (61-50), 3-2 | Metropolitan Stadium (41-21) | 62-50 | Won 4 |
| » W: Jim Merritt (9-3) L: Bob Locker (5-3) | First | -- |
| Monday, August 14 |
| » Defeated Angels (62-54), 2-1 | Anaheim Stadium (4-3) | 63-50 | Won 5 |
| » W: Dave Boswell (10-8) L: George Brunet (11-14) S: Al Worthington (13) | First | -- |
| » Major-league debuts: Moose Stubing (Angels) |
| Tuesday, August 15 |
| » Defeated Angels (62-55), 4-0 | Anaheim Stadium (5-3) | 64-50 | Won 6 |
| » W: Jim Perry (5-5) L: Curt Simmons (4-1) | First | -- |
| Wednesday, August 16 |
| » Defeated Angels (62-56), 5-1 | Anaheim Stadium (6-3) | 65-50 | Won 7 |
| » W: Dean Chance (16-8) L: Jim McGlothlin (10-5) | First | -- |
| Friday, August 18 |
| » Lost to Yankees (52-65), 1-0 | Yankee Stadium (2-4) | 65-51 | |
| » W: Steve Barber (9-13) L: Jim Kaat (9-12) | First | -- |
| » Defeated Yankees (52-66), 4-3 | Yankee Stadium (3-4) | 66-51 | |
| » W: Ron Kline (5-0) L: Fred Talbot (5-5) S: Al Worthington (14) | First | -- |
| Saturday, August 19 |
| » Defeated Yankees (52-67), 1-0 | Yankee Stadium (4-4) | 67-51 | Won 2 |
| » W: Dave Boswell (11-8) L: Bill Monbouquette (2-3) | First | -- |
| Sunday, August 20 |
| » Lost to Yankees (53-67), 7-3 | Yankee Stadium (4-5) | 67-52 | |
| » W: Mel Stottlemyre (12-10) L: Jim Perry (5-6) S: Joe Verbanic (1) | First | -- |
| Tuesday, August 22 |
| » Lost to Tigers (67-55), 7-3 | Tiger Stadium (2-3) | 67-53 | Lost 2 |
| » W: Earl Wilson (17-9) L: Dean Chance (16-9) | Third | 1 out |
| » Lost to Tigers (68-55), 2-1 | Tiger Stadium (2-4) | 67-54 | Lost 3 |
| » W: Fred Lasher (1-0) L: Al Worthington (7-8) | Third | 1 out |
| Wednesday, August 23 |
| » Lost to Tigers (69-55), 10-0 | Tiger Stadium (2-5) | 67-55 | Lost 4 |
| » W: Joe Sparma (13-6) L: Jim Merritt (9-4) | Third | 1½ out |
| » Defeated Tigers (69-56), 4-3 | Tiger Stadium (3-5) | 68-55 | |
| » W: Jim Perry (6-6) L: Dave Wickersham (4-5) S: Ron Kline (5) | Third | 1½ out |
| Thursday, August 24 |
| » Defeated Tigers (69-57), 4-2 | Tiger Stadium (4-5) | 69-55 | Won 2 |
| » W: Al Worthington (8-8) L: Denny McLain (16-14) | Third | ½ out |
| Friday, August 25 |
| » Defeated Indians (60-68), 6-5 | Cleveland Stadium (2-4) | 70-55 | Won 3 |
| » W: Ron Kline (6-0) L: John O'Donoghue (7-7) | First | -- |
| » Defeated Indians (60-69), 2-1 | Cleveland Stadium (3-4) | 71-55 | Won 4 |
| » W: Dean Chance (17-9) L: Sonny Siebert (6-11) | First | -- |
| Saturday, August 26 |
| » Lost to Indians (61-69), 5-2 | Cleveland Stadium (3-5) | 71-56 | |
| » W: Steve Hargan (14-10) L: Jim Kaat (9-13) | Second | ½ out |
| Sunday, August 27 |
| » Defeated Indians (61-70), 6-3 | Cleveland Stadium (4-5) | 72-56 | |
| » W: Jim Merritt (10-4) L: Luis Tiant (8-9) | Second | 1 out |
| Monday, August 28 |
| » Defeated Orioles (57-70), 3-2 | Metropolitan Stadium (42-21) | 73-56 | Won 2 |
| » W: Jim Perry (7-6) L: Pete Richert (8-13) S: Al Worthington (15) | First | -- |
| Tuesday, August 29 |
| » Lost to Orioles (58-70), 4-3 | Metropolitan Stadium (42-22) | 73-57 | |
| » W: Jim Hardin (4-1) L: Dave Boswell (11-9) S: Moe Drabowsky (10) | Second | 1½ out |
| Wednesday, August 30 |
| » Lost to Orioles (59-70), 4-2 | Metropolitan Stadium (42-23) | 73-58 | Lost 2 |
| » W: Eddie Watt (2-4) L: Dean Chance (17-10) | Second | 1½ out |
| Thursday, August 31 |
| » Defeated Orioles (59-71), 10-9 | Metropolitan Stadium (43-23) | 74-58 | |
| » W: Ron Kline (7-0) L: Moe Drabowsky (7-5) | Second | 1½ out |
| Friday, September 1 |
| » Defeated Tigers (74-60), 5-4 | Metropolitan Stadium (44-23) | 75-58 | Won 2 |
| » W: Jim Kaat (10-13) L: Joe Sparma (13-8) | Second | 1½ out |
| Saturday, September 2 |
| » Defeated Tigers (74-61), 5-0 | Metropolitan Stadium (45-23) | 76-58 | Won 3 |
| » W: Dave Boswell (12-9) L: Denny McLain (17-15) | First | -- |
| » Major-league debuts: Tommy Matchick (Tigers) |
| Sunday, September 3 |
| » Lost to Tigers (75-61), 5-0 | Metropolitan Stadium (45-24) | 76-59 | |
| » W: Earl Wilson (19-10) L: Dean Chance (17-11) S: Fred Lasher (4) | First | -- |
| Monday, September 4 |
| » Defeated Indians (63-75), 4-1 | Metropolitan Stadium (46-24) | 77-59 | |
| » W: Jim Merritt (11-4) L: Steve Hargan (14-12) | First | -- |
| » Lost to Indians (64-75), 2-1 | Metropolitan Stadium (46-25) | 77-60 | |
| » W: Sonny Siebert (7-11) L: Al Worthington (8-9) S: George Culver (3) | First | -- |
| Tuesday, September 5 |
| » Defeated Indians (64-76), 9-2 | Metropolitan Stadium (47-25) | 78-60 | |
| » W: Jim Kaat (11-13) L: Sam McDowell (11-13) | First | -- |
| Wednesday, September 6 |
| » Lost to Indians (65-76), 3-2 | Metropolitan Stadium (47-26) | 78-61 | |
| » W: Luis Tiant (9-9) L: Dave Boswell (12-10) | First | -- |
| » Major-league debuts: Pat Kelly and Graig Nettles (Twins) |
| Thursday, September 7 |
| » Defeated Orioles (62-76), 4-2 | Memorial Stadium (2-3) | 79-61 | |
| » W: Dean Chance (18-11) L: Jim Hardin (5-2) | First | -- |
| Friday, September 8 |
| » Defeated Orioles (62-77), 7-2 | Memorial Stadium (3-3) | 80-61 | Won 2 |
| » W: Jim Merritt (12-4) L: Gene Brabender (4-4) | First | -- |
| » Lost to Orioles (63-77), 5-3 | Memorial Stadium (3-4) | 80-62 | |
| » W: Tom Phoebus (12-8) L: Jim Perry (7-7) S: Pete Richert (1) | First | -- |
| Saturday, September 9 |
| » Defeated Orioles (63-78), 3-2 | Memorial Stadium (4-4) | 81-62 | |
| » W: Jim Kaat (12-13) L: Bill Dillman (5-9) | First | -- |
| Sunday, September 10 |
| » Defeated Orioles (63-79), 4-2 | Memorial Stadium (5-4) | 82-62 | Won 2 |
| » W: Dave Boswell (13-10) L: Wally Bunker (3-7) | First | -- |
| Monday, September 11 |
| » Defeated Senators (68-76), 13-5 | Robert F. Kennedy Stadium (3-4) | 83-62 | Won 3 |
| » W: Jim Perry (8-7) L: Casey Cox (7-3) | First | -- |
| Tuesday, September 12 |
| » Lost to Senators (69-76), 5-4 | Robert F. Kennedy Stadium (3-5) | 83-63 | |
| » W: Frank Bertaina (5-5) L: Jim Merritt (12-5) S: Darold Knowles (13) | First | -- |
| Wednesday, September 13 |
| » Defeated Senators (69-77), 3-2 | Robert F. Kennedy Stadium (4-5) | 84-63 | |
| » W: Jim Kaat (13-13) L: Phil Ortega (9-9) S: Dean Chance (1) | First | -- |
| Thursday, September 14 |
| » Major-league debuts: Cito Gaston (Braves) |
| Former Twin Walt Bond dies in Houston, TX at the age of 30. |
| Friday, September 15 |
| » Lost to White Sox (83-66), 7-3 | Comiskey Park I (3-4) | 84-64 | |
| » W: Joe Horlen (17-6) L: Dave Boswell (13-11) | First | -- |
| Future Twin Paul Abbott is born in Van Nuys, CA. |
| Saturday, September 16 |
| » Lost to White Sox (84-66), 5-4 | Comiskey Park I (3-5) | 84-65 | Lost 2 |
| » W: Bob Locker (7-4) L: Dean Chance (18-12) | Second | 1 out |
| Sunday, September 17 |
| » Lost to White Sox (85-66), 4-0 | Comiskey Park I (3-6) | 84-66 | Lost 3 |
| » W: Gary Peters (16-9) L: Jim Merritt (12-6) | Third | 1 out |
| Monday, September 18 |
| » Defeated Athletics (59-90), 2-0 | Municipal Stadium (4-4) | 85-66 | |
| » W: Jim Kaat (14-13) L: Catfish Hunter (11-16) | First | -- |
| Tuesday, September 19 |
| » Defeated Athletics (59-91), 8-2 | Municipal Stadium (5-4) | 86-66 | Won 2 |
| » W: Dave Boswell (14-11) L: Jim Nash (12-15) | First | -- |
| Wednesday, September 20 |
| » Defeated Athletics (59-92), 6-2 | Metropolitan Stadium (48-26) | 87-66 | Won 3 |
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