| Friday, January 6 |
| Former Senator Joe Haynes dies in Hopkins, MN at the age of 50. |
| Friday, January 13 |
| Former Senator Charley Gelbert dies in Easton, PA at the age of 61. |
| Saturday, February 18 |
| Former Senator Ralph Miller dies in White Bear Lake, MN at the age of 69. |
| Friday, April 7 |
| Former Senator Shanty Hogan dies in Boston, MA at the age of 62. |
| Monday, April 10 |
| » Lost to Yankees (1-0), 8-0 | Robert F. Kennedy Stadium (0-1) | 0-1 | |
| » W: Mel Stottlemyre (1-0) L: Pete Richert (0-1) | Third | 1 out |
| Wednesday, April 12 |
| » Defeated Yankees (1-1), 10-4 | Robert F. Kennedy Stadium (1-1) | 1-1 | |
| » W: Joe Coleman (1-0) L: Fritz Peterson (0-1) | Second | ½ out |
| Saturday, April 15 |
| » Defeated White Sox (1-2), 3-1 | Comiskey Park I (1-0) | 2-1 | Won 2 |
| » W: Darold Knowles (1-0) L: Dennis Higgins (0-1) | Second | ½ out |
| Sunday, April 16 |
| » Lost to White Sox (2-2), 7-3 | Comiskey Park I (1-1) | 2-2 | |
| » W: Joe Horlen (1-0) L: Phil Ortega (0-1) | Fifth | 1½ out |
| » Lost to White Sox (3-2), 4-3 | Comiskey Park I (1-2) | 2-3 | Lost 2 |
| » W: Dennis Higgins (1-1) L: Darold Knowles (1-1) | Fifth | 1½ out |
| Thursday, April 20 |
| » Lost to White Sox (5-3), 8-4 | Robert F. Kennedy Stadium (1-2) | 2-4 | Lost 3 |
| » W: John Buzhardt (1-1) L: Pete Richert (0-2) | Sixth | 2 out |
| Friday, April 21 |
| » Defeated White Sox (5-4), 4-3 | Robert F. Kennedy Stadium (2-2) | 3-4 | |
| » W: Joe Coleman (2-0) L: Gary Peters (0-1) | Sixth | 2 out |
| Saturday, April 22 |
| » Lost to White Sox (6-4), 1-0 | Robert F. Kennedy Stadium (2-3) | 3-5 | |
| » W: Joe Horlen (2-0) L: Phil Ortega (0-2) | Sixth | 2 out |
| Sunday, April 23 |
| » Defeated White Sox (6-5), 5-1 | Robert F. Kennedy Stadium (3-3) | 4-5 | |
| » W: Barry Moore (1-0) L: Bruce Howard (1-1) | Fifth | 1½ out |
| Monday, April 24 |
| » Lost to Red Sox (5-5), 7-4 | Robert F. Kennedy Stadium (3-4) | 4-6 | |
| » W: John Wyatt (1-0) L: Dick Lines (0-1) | Seventh | 2 out |
| Tuesday, April 25 |
| » Lost to Red Sox (6-5), 9-3 | Robert F. Kennedy Stadium (3-5) | 4-7 | Lost 2 |
| » W: Hank Fischer (1-1) L: Pete Richert (0-3) | Ninth | 2½ out |
| Friday, April 28 |
| » Lost to Twins (5-7), 7-3 | Robert F. Kennedy Stadium (3-6) | 4-8 | Lost 3 |
| » W: Dean Chance (2-1) L: Joe Coleman (2-1) | Ninth | 3½ out |
| Saturday, April 29 |
| » Defeated Twins (5-8), 9-6 | Robert F. Kennedy Stadium (4-6) | 5-8 | |
| » W: Darold Knowles (2-1) L: Jim Perry (0-1) | Fifth | 3 out |
| Sunday, April 30 |
| » Defeated Twins (5-9), 7-3 | Robert F. Kennedy Stadium (5-6) | 6-8 | Won 2 |
| » W: Camilo Pascual (1-0) L: Mudcat Grant (0-3) S: Bob Humphreys (1) | Seventh | 2½ out |
| » Defeated Twins (5-10), 3-0 | Robert F. Kennedy Stadium (6-6) | 7-8 | Won 3 |
| » W: Barry Moore (2-0) L: Jim Kaat (1-3) | Seventh | 2½ out |
| Tuesday, May 2 |
| » Defeated Athletics (6-10), 1-0 | Municipal Stadium (1-0) | 8-8 | Won 4 |
| » W: Pete Richert (1-3) L: Lew Krausse (0-4) S: Darold Knowles (1) | Fifth | 2½ out |
| » Lost to Athletics (7-10), 1-0 | Municipal Stadium (1-1) | 8-9 | |
| » W: Catfish Hunter (3-1) L: Jim Hannan (0-1) | Fifth | 2½ out |
| Wednesday, May 3 |
| » Defeated Athletics (7-11), 6-1 | Municipal Stadium (2-1) | 9-9 | |
| » W: Phil Ortega (1-2) L: Chuck Dobson (0-1) | Third | 1½ out |
| Friday, May 5 |
| » Defeated Angels (10-11), 4-1 | Anaheim Stadium (1-0) | 10-9 | Won 2 |
| » W: Camilo Pascual (2-0) L: George Brunet (1-4) | Third | 1½ out |
| Saturday, May 6 |
| » Defeated Angels (10-12), 2-0 | Anaheim Stadium (2-0) | 11-9 | Won 3 |
| » W: Darold Knowles (3-1) L: Rickey Clark (2-1) | Second | 1½ out |
| Sunday, May 7 |
| » Lost to Angels (11-12), 5-0 | Anaheim Stadium (2-1) | 11-10 | |
| » W: Jim McGlothlin (2-0) L: Pete Richert (1-4) | Fourth | 2½ out |
| Monday, May 8 |
| » Defeated Twins (9-12), 7-4 | Metropolitan Stadium (1-0) | 12-10 | |
| » W: Jim Hannan (1-1) L: Al Worthington (1-2) S: Dave Baldwin (1) | Third | 2 out |
| Tuesday, May 9 |
| » Lost to Twins (10-12), 11-1 | Metropolitan Stadium (1-1) | 12-11 | |
| » W: Mudcat Grant (2-3) L: Joe Coleman (2-2) | Fourth | 3 out |
| Thursday, May 11 |
| » Lost to Indians (9-13), 2-1 | Robert F. Kennedy Stadium (6-7) | 12-12 | Lost 2 |
| » W: Steve Hargan (3-3) L: Camilo Pascual (2-1) | Fourth | 4 out |
| Friday, May 12 |
| » Lost to Indians (10-13), 12-5 | Robert F. Kennedy Stadium (6-8) | 12-13 | Lost 3 |
| » W: George Culver (2-0) L: Bob Priddy (0-1) | Fourth | 5 out |
| Saturday, May 13 |
| » Lost to Indians (11-13), 3-1 | Robert F. Kennedy Stadium (6-9) | 12-14 | Lost 4 |
| » W: Luis Tiant (1-1) L: Pete Richert (1-5) S: Orlando Pena (1) | Fourth | 6 out |
| Sunday, May 14 |
| » Lost to Indians (12-13), 2-1 | Robert F. Kennedy Stadium (6-10) | 12-15 | Lost 5 |
| » W: Sonny Siebert (3-2) L: Phil Ortega (1-3) | Fifth | 7 out |
| Tuesday, May 16 |
| » Defeated Tigers (17-10), 5-4 | Robert F. Kennedy Stadium (7-10) | 13-15 | |
| » W: Camilo Pascual (3-1) L: Earl Wilson (4-3) S: Dave Baldwin (2) | Fifth | 6 out |
| Wednesday, May 17 |
| » Lost to Tigers (18-10), 8-1 | Robert F. Kennedy Stadium (7-11) | 13-16 | |
| » W: Joe Sparma (4-0) L: Barry Moore (2-1) | Sixth | 7 out |
| Thursday, May 18 |
| » Defeated Orioles (13-16), 2-0 | Robert F. Kennedy Stadium (8-11) | 14-16 | |
| » W: Pete Richert (2-5) L: Frank Bertaina (0-1) | Fifth | 6½ out |
| Friday, May 19 |
| » Lost to Orioles (14-16), 11-5 | Robert F. Kennedy Stadium (8-12) | 14-17 | |
| » W: Steve Barber (3-3) L: Phil Ortega (1-4) S: Wally Bunker (1) | Sixth | 7½ out |
| Saturday, May 20 |
| » Lost to Orioles (15-16), 4-3 | Robert F. Kennedy Stadium (8-13) | 14-18 | Lost 2 |
| » W: Dave McNally (2-2) L: Joe Coleman (2-3) S: Moe Drabowsky (3) | Ninth | 7½ out |
| Monday, May 22 |
| » Lost to Indians (15-17), 5-0 | Cleveland Stadium (0-1) | 14-19 | Lost 3 |
| » W: Steve Hargan (5-3) L: Camilo Pascual (3-2) | Eighth | 7½ out |
| Tuesday, May 23 |
| » Lost to Indians (16-17), 4-1 | Cleveland Stadium (0-2) | 14-20 | Lost 4 |
| » W: Steve Bailey (2-0) L: Bob Priddy (0-2) | Ninth | 8 out |
| Wednesday, May 24 |
| » Lost to Indians (17-17), 9-1 | Cleveland Stadium (0-3) | 14-21 | Lost 5 |
| » W: Luis Tiant (2-1) L: Phil Ortega (1-5) | Ninth | 9 out |
| Thursday, May 25 |
| » Defeated Indians (17-18), 2-1 | Cleveland Stadium (1-3) | 15-21 | |
| » W: Barry Moore (3-1) L: Steve Bailey (2-1) S: Dave Baldwin (3) | Ninth | 8½ out |
| Friday, May 26 |
| » Lost to Tigers (23-13), 10-5 | Tiger Stadium (0-1) | 15-22 | |
| » W: Dave Wickersham (2-0) L: Darold Knowles (3-2) | Ninth | 9 out |
| Saturday, May 27 |
| » Defeated Tigers (23-14), 8-1 | Tiger Stadium (1-1) | 16-22 | |
| » W: Camilo Pascual (4-2) L: Mickey Lolich (5-4) | Seventh | 9 out |
| Sunday, May 28 |
| » Lost to Tigers (24-14), 3-1 | Tiger Stadium (1-2) | 16-23 | |
| » W: Denny McLain (5-5) L: Pete Richert (2-6) S: Fred Gladding (7) | Ninth | 9 out |
| Tuesday, May 30 |
| » Defeated Athletics (19-22), 6-2 | Robert F. Kennedy Stadium (9-13) | 17-23 | |
| » W: Phil Ortega (2-5) L: Jim Nash (5-5) | Eighth | 8½ out |
| » Defeated Athletics (19-23), 4-3 | Robert F. Kennedy Stadium (10-13) | 18-23 | Won 2 |
| » W: Bob Humphreys (1-0) L: Jack Aker (2-3) | Eighth | 8½ out |
| Wednesday, May 31 |
| » Defeated Angels (18-27), 6-3 | Robert F. Kennedy Stadium (11-13) | 19-23 | Won 3 |
| » W: Joe Coleman (3-3) L: Nick Willhite (0-2) | Seventh | 7½ out |
| Thursday, June 1 |
| » Defeated Angels (18-28), 1-0 | Robert F. Kennedy Stadium (12-13) | 20-23 | Won 4 |
| » W: Camilo Pascual (5-2) L: Rickey Clark (2-5) | Seventh | 6½ out |
| Friday, June 2 |
| » Lost to Orioles (21-20), 12-0 | Memorial Stadium (0-1) | 20-24 | |
| » W: Tom Phoebus (4-1) L: Darold Knowles (3-3) | Seventh | 7½ out |
| Saturday, June 3 |
| » Lost to Orioles (22-20), 3-2 | Memorial Stadium (0-2) | 20-25 | Lost 2 |
| » W: Moe Drabowsky (4-0) L: Darold Knowles (3-4) | Ninth | 7½ out |
| Sunday, June 4 |
| » Lost to Orioles (23-20), 7-5 | Memorial Stadium (0-3) | 20-26 | Lost 3 |
| » W: Stu Miller (1-4) L: Bob Priddy (0-3) | Ninth | 8 out |
| Monday, June 5 |
| » Lost to Yankees (21-24), 4-2 | Yankee Stadium (0-1) | 20-27 | Lost 4 |
| » W: Thad Tillotson (3-0) L: Darold Knowles (3-5) | Ninth | 9 out |
| Tuesday, June 6 |
| » Lost to Yankees (22-24), 7-1 | Yankee Stadium (0-2) | 20-28 | Lost 5 |
| » W: Mel Stottlemyre (5-5) L: Camilo Pascual (5-3) | Ninth | 10½ out |
| Wednesday, June 7 |
| » Lost to Yankees (23-24), 7-1 | Yankee Stadium (0-3) | 20-29 | Lost 6 |
| » W: Fred Talbot (2-2) L: Barry Moore (3-2) | Ninth | 10 out |
| » Defeated Yankees (23-25), 2-1 | Yankee Stadium (1-3) | 21-29 | |
| » W: Phil Ortega (3-5) L: Bill Monbouquette (0-1) S: Darold Knowles (2) | Ninth | 10 out |
| Thursday, June 8 |
| » Lost to Yankees (24-25), 6-0 | Yankee Stadium (1-4) | 21-30 | |
| » W: Joe Verbanic (2-0) L: Joe Coleman (3-4) | Eighth | 10½ out |
| Friday, June 9 |
| » Lost to Red Sox (26-24), 8-7 | Fenway Park (0-1) | 21-31 | Lost 2 |
| » W: Jose Santiago (3-2) L: Bob Humphreys (1-1) S: John Wyatt (6) | Ninth | 10½ out |
| Saturday, June 10 |
| » Defeated Red Sox (26-25), 7-3 | Fenway Park (1-1) | 22-31 | |
| » W: Camilo Pascual (6-3) L: Lee Stange (0-4) S: Dave Baldwin (4) | Tenth | 9½ out |
| Sunday, June 11 |
| » Lost to Red Sox (27-25), 4-3 | Fenway Park (1-2) | 22-32 | |
| » W: Jose Santiago (4-2) L: Dave Baldwin (0-1) S: John Wyatt (7) | Ninth | 10 out |
| » Defeated Red Sox (27-26), 8-7 | Fenway Park (2-2) | 23-32 | |
| » W: Casey Cox (1-0) L: Dan Osinski (2-1) S: Bob Priddy (1) | Ninth | 10 out |
| » Major-league debuts: Gary Waslewski (Red Sox) |
| Monday, June 12 |
| » Defeated White Sox (31-21), 6-5 | Robert F. Kennedy Stadium (13-13) | 24-32 | Won 2 |
| » W: Bob Humphreys (2-1) L: John Buzhardt (2-5) | Ninth | 9 out |
| Tuesday, June 13 |
| » Lost to White Sox (32-21), 6-0 | Robert F. Kennedy Stadium (13-14) | 24-33 | |
| » W: Tommy John (5-3) L: Barry Moore (3-3) | Tenth | 10 out |
| Wednesday, June 14 |
| » Lost to Yankees (27-29), 7-1 | Robert F. Kennedy Stadium (13-15) | 24-34 | Lost 2 |
| » W: Al Downing (7-3) L: Camilo Pascual (6-4) | Ninth | 10 out |
| » Defeated Yankees (27-30), 3-2 | Robert F. Kennedy Stadium (14-15) | 25-34 | |
| » W: Phil Ortega (4-5) L: Thad Tillotson (3-2) S: Darold Knowles (3) | Ninth | 10 out |
| Thursday, June 15 |
| » Lost to Yankees (28-30), 2-0 | Robert F. Kennedy Stadium (14-16) | 25-35 | |
| » W: Mel Stottlemyre (6-6) L: Frank Bertaina (1-2) | Eighth | 10 out |
| Friday, June 16 |
| » Defeated Red Sox (30-29), 1-0 | Robert F. Kennedy Stadium (15-16) | 26-35 | |
| » W: Bob Priddy (1-3) L: Gary Bell (3-6) S: Dave Baldwin (5) | Ninth | 9 out |
| » Defeated Red Sox (30-30), 4-3 | Robert F. Kennedy Stadium (16-16) | 27-35 | Won 2 |
| » W: Casey Cox (2-0) L: John Wyatt (4-3) | Ninth | 9 out |
| Saturday, June 17 |
| » Lost to Red Sox (31-30), 5-1 | Robert F. Kennedy Stadium (16-17) | 27-36 | |
| » W: Jim Lonborg (8-2) L: Barry Moore (3-4) | Ninth | 10 out |
| Sunday, June 18 |
| » Defeated Red Sox (31-31), 3-2 | Robert F. Kennedy Stadium (17-17) | 28-36 | |
| » W: Darold Knowles (4-5) L: Jose Santiago (4-3) | Tenth | 10½ out |
| Tuesday, June 20 |
| » Defeated White Sox (36-24), 4-2 | Comiskey Park I (2-2) | 29-36 | Won 2 |
| » W: Frank Bertaina (2-2) L: Bruce Howard (2-5) S: Darold Knowles (4) | Ninth | 9½ out |
| Wednesday, June 21 |
| » Lost to White Sox (37-24), 5-2 | Comiskey Park I (2-3) | 29-37 | |
| » W: Bruce Howard (3-5) L: Joe Coleman (3-5) S: Hoyt Wilhelm (4) | Ninth | 11½ out |
| » Lost to White Sox (38-24), 2-1 | Comiskey Park I (2-4) | 29-38 | Lost 2 |
| » W: Jim O'Toole (4-1) L: Barry Moore (3-5) S: Bob Locker (9) | Ninth | 11½ out |
| Friday, June 23 |
| » Defeated Orioles (31-33), 3-2 | Robert F. Kennedy Stadium (18-17) | 30-38 | |
| » W: Phil Ortega (5-5) L: Steve Barber (4-7) S: Darold Knowles (5) | Tenth | 10½ out |
| » Major-league debuts: Jim Hardin (Orioles) |
| Saturday, June 24 |
| » Defeated Orioles (31-34), 8-3 | Memorial Stadium (1-3) | 31-38 | Won 2 |
| » W: Camilo Pascual (7-4) L: Bill Dillman (4-2) | Tenth | 10½ out |
| Sunday, June 25 |
| » Lost to Orioles (32-34), 8-3 | Robert F. Kennedy Stadium (18-18) | 31-39 | |
| » W: Tom Phoebus (6-3) L: Bob Priddy (1-4) S: Moe Drabowsky (5) | Tenth | 10½ out |
| Monday, June 26 |
| » Lost to Angels (36-37), 4-3 | Anaheim Stadium (2-2) | 31-40 | Lost 2 |
| » W: Jack Hamilton (3-0) L: Barry Moore (3-6) S: Minnie Rojas (9) | Eighth | 11½ out |
| Tuesday, June 27 |
| » Defeated Angels (36-38), 9-4 | Anaheim Stadium (3-2) | 32-40 | |
| » W: Joe Coleman (4-5) L: Jim McGlothlin (7-2) | Ninth | 11½ out |
| Wednesday, June 28 |
| » Lost to Angels (37-38), 4-2 | Anaheim Stadium (3-3) | 32-41 | |
| » W: Minnie Rojas (7-5) L: Dick Lines (0-2) | Ninth | 12½ out |
| Saturday, July 1 |
| » Lost to Twins (37-34), 4-0 | Metropolitan Stadium (1-2) | 32-42 | Lost 2 |
| » W: Jim Kaat (6-8) L: Barry Moore (3-7) | Ninth | 12½ out |
| Sunday, July 2 |
| » Lost to Twins (38-34), 4-1 | Metropolitan Stadium (1-3) | 32-43 | Lost 3 |
| » W: Dean Chance (11-6) L: Camilo Pascual (7-5) | Eighth | 13 out |
| » Lost to Twins (39-34), 6-1 | Metropolitan Stadium (1-4) | 32-44 | Lost 4 |
| » W: Jim Merritt (6-0) L: Joe Coleman (4-6) | Eighth | 13 out |
| Tuesday, July 4 |
| » Defeated Athletics (34-44), 4-3 | Municipal Stadium (3-1) | 33-44 | |
| » W: Phil Ortega (6-5) L: Lew Krausse (4-11) S: Darold Knowles (6) | Tenth | 13 out |
| » Lost to Athletics (35-44), 4-0 | Municipal Stadium (3-2) | 33-45 | |
| » W: Jim Nash (9-7) L: Bob Priddy (1-5) | Tenth | 13 out |
| Wednesday, July 5 |
| » Defeated Athletics (35-45), 5-3 | Municipal Stadium (4-2) | 34-45 | |
| » W: Barry Moore (4-7) L: Chuck Dobson (4-6) S: Darold Knowles (7) | Tenth | 13 out |
| Friday, July 7 |
| » Lost to Indians (39-40), 6-3 | Cleveland Stadium (1-4) | 34-46 | |
| » W: Sam McDowell (5-7) L: Camilo Pascual (7-6) | Tenth | 13½ out |
| Saturday, July 8 |
| » Lost to Indians (40-40), 4-3 | Cleveland Stadium (1-5) | 34-47 | Lost 2 |
| » W: George Culver (6-1) L: Casey Cox (2-1) | Tenth | 14½ out |
| Sunday, July 9 |
| » Defeated Indians (40-41), 8-5 | Cleveland Stadium (2-5) | 35-47 | |
| » W: Dick Lines (1-2) L: Steve Bailey (2-3) S: Bob Humphreys (2) | Ninth | 12½ out |
| » Defeated Indians (40-42), 4-2 | Cleveland Stadium (3-5) | 36-47 | Won 2 |
| » W: Barry Moore (5-7) L: Sonny Siebert (6-8) S: Dave Baldwin (6) | Ninth | 12½ out |
| Thursday, July 13 |
| » Defeated Tigers (45-36), 8-3 | Robert F. Kennedy Stadium (19-18) | 37-47 | Won 3 |
| » W: Camilo Pascual (8-6) L: Joe Sparma (9-2) | Eighth | 11½ out |
| » Defeated Tigers (45-37), 6-1 | Robert F. Kennedy Stadium (20-18) | 38-47 | Won 4 |
| » W: Joe Coleman (5-6) L: Denny McLain (10-10) | Eighth | 11½ out |
| Former Senator Art Shires dies in Italy, TX at the age of 60. |
| Friday, July 14 |
| » Defeated Tigers (45-38), 3-1 | Robert F. Kennedy Stadium (21-18) | 39-47 | Won 5 |
| » W: Phil Ortega (7-5) L: Earl Wilson (10-8) S: Dave Baldwin (7) | Eighth | 11 out |
| Saturday, July 15 |
| » Defeated Tigers (45-39), 3-2 | Robert F. Kennedy Stadium (22-18) | 40-47 | Won 6 |
| » W: Casey Cox (3-1) L: Mickey Lolich (5-11) S: Dick Lines (1) | Eighth | 10 out |
| Sunday, July 16 |
| » Defeated Indians (42-46), 4-1 | Robert F. Kennedy Stadium (23-18) | 41-47 | Won 7 |
| » W: Bob Humphreys (3-1) L: Sam McDowell (6-8) S: Bob Priddy (2) | Seventh | 9½ out |
| Monday, July 17 |
| » Defeated Indians (42-47), 4-2 | Robert F. Kennedy Stadium (24-18) | 42-47 | Won 8 |
| » W: Joe Coleman (6-6) L: Luis Tiant (7-4) S: Darold Knowles (8) | Seventh | 9 out |
| Tuesday, July 18 |
| » Lost to Tigers (46-41), 5-2 | Tiger Stadium (1-3) | 42-48 | |
| » W: Earl Wilson (11-8) L: Camilo Pascual (8-7) | Seventh | 9 out |
| Wednesday, July 19 |
| » Defeated Tigers (46-42), 4-2 | Tiger Stadium (2-3) | 43-48 | |
| » W: Darold Knowles (5-5) L: Fred Gladding (3-4) | Seventh | 8 out |
| Thursday, July 20 |
| » Lost to Tigers (47-42), 8-4 | Tiger Stadium (2-4) | 43-49 | |
| » W: Joe Sparma (10-3) L: Barry Moore (5-8) | Eighth | 8½ out |
| Friday, July 21 |
| » Defeated Orioles (42-49), 4-3 | Memorial Stadium (2-3) | 44-49 | |
| » W: Bob Humphreys (4-1) L: Tom Phoebus (8-5) S: Darold Knowles (9) | Sixth | 8 out |
| » Defeated Orioles (42-50), 3-1 | Memorial Stadium (3-3) | 45-49 | Won 2 |
| » W: Joe Coleman (7-6) L: Dave McNally (6-7) S: Darold Knowles (10) | Sixth | 8 out |
| Saturday, July 22 |
| » Defeated Orioles (42-51), 7-5 | Memorial Stadium (4-3) | 46-49 | Won 3 |
| » W: Camilo Pascual (9-7) L: Gene Brabender (0-1) S: Dick Lines (2) | Fifth | 7 out |
| Sunday, July 23 |
| » Lost to Orioles (43-51), 7-3 | Robert F. Kennedy Stadium (24-19) | 46-50 | |
| » W: Eddie Fisher (3-2) L: Dave Baldwin (0-2) | Sixth | 8½ out |
| Tuesday, July 25 |
| » Lost to Athletics (41-55), 5-1 | Robert F. Kennedy Stadium (24-20) | 46-51 | Lost 2 |
| » W: Catfish Hunter (9-9) L: Frank Bertaina (2-3) | Sixth | 10½ out |
| » Lost to Athletics (42-55), 6-5 | Robert F. Kennedy Stadium (24-21) | 46-52 | Lost 3 |
| » W: Chuck Dobson (6-6) L: Barry Moore (5-9) S: Diego Segui (1) | Sixth | 10½ out |
| Former Senator Mike Chartak dies in Cedar Rapids, IA at the age of 52. |
| Wednesday, July 26 |
| » Defeated Athletics (42-56), 6-3 | Robert F. Kennedy Stadium (25-21) | 47-52 | |
| » W: Joe Coleman (8-6) L: Lew Krausse (5-13) S: Dave Baldwin (8) | Sixth | 10 out |
| Thursday, July 27 |
| » Defeated Athletics (42-57), 6-4 | Robert F. Kennedy Stadium (26-21) | 48-52 | Won 2 |
| » W: Camilo Pascual (10-7) L: Paul Lindblad (5-5) S: Dave Baldwin (9) | Sixth | 9½ out |
| Friday, July 28 |
| » Defeated Angels (54-47), 8-2 | Robert F. Kennedy Stadium (27-21) | 49-52 | Won 3 |
| » W: Phil Ortega (8-5) L: Jack Hamilton (7-2) | Sixth | 8½ out |
| Saturday, July 29 |
| » Defeated Angels (54-48), 3-2 | Robert F. Kennedy Stadium (28-21) | 50-52 | Won 4 |
| » W: Casey Cox (4-1) L: Minnie Rojas (7-7) S: Dave Baldwin (10) | Sixth | 8½ out |
| Sunday, July 30 |
| » Defeated Angels (54-49), 11-1 | Robert F. Kennedy Stadium (29-21) | 51-52 | Won 5 |
| » W: Barry Moore (6-9) L: Rickey Clark (8-7) S: Bob Humphreys (3) | Sixth | 8½ out |
| » Lost to Angels (55-49), 10-2 | Robert F. Kennedy Stadium (29-22) | 51-53 | |
| » W: George Brunet (10-12) L: Joe Coleman (8-7) S: Bill Kelso (6) | Sixth | 8½ out |
| Tuesday, August 1 |
| » Lost to Twins (54-47), 5-4 | Robert F. Kennedy Stadium (29-23) | 51-54 | Lost 2 |
| » W: Dean Chance (13-8) L: Camilo Pascual (10-8) S: Al Worthington (12) | Sixth | 10 out |
| Wednesday, August 2 |
| » Defeated Twins (54-48), 5-4 | Robert F. Kennedy Stadium (30-23) | 52-54 | |
| » W: Casey Cox (5-1) L: Al Worthington (6-7) | Sixth | 9 out |
| Friday, August 4 |
| » Lost to Angels (57-50), 5-4 | Anaheim Stadium (3-4) | 52-55 | |
| » W: George Brunet (11-12) L: Joe Coleman (8-8) S: Minnie Rojas (19) | Sixth | 9½ out |
| Saturday, August 5 |
| » Defeated Angels (57-51), 9-1 | Anaheim Stadium (4-4) | 53-55 | |
| » W: Barry Moore (7-9) L: Rickey Clark (8-8) | Fifth | 9 out |
| Sunday, August 6 |
| » Defeated Angels (57-52), 7-2 | Anaheim Stadium (5-4) | 54-55 | Won 2 |
| » W: Camilo Pascual (11-8) L: Jim McGlothlin (9-4) S: Darold Knowles (11) | Sixth | 7½ out |
| Monday, August 7 |
| » Defeated Twins (57-49), 5-0 | Metropolitan Stadium (2-4) | 55-55 | Won 3 |
| » W: Phil Ortega (9-5) L: Jim Kaat (8-11) | Fifth | 7 out |
| Tuesday, August 8 |
| » Lost to Twins (58-49), 3-2 | Metropolitan Stadium (2-5) | 55-56 | |
| » W: Al Worthington (7-7) L: Dave Baldwin (0-3) | Sixth | 7½ out |
| Wednesday, August 9 |
| » Defeated Twins (58-50), 9-7 | Metropolitan Stadium (3-5) | 56-56 | |
| » W: Dave Baldwin (1-3) L: Jim Roland (0-1) | Sixth | 6½ out |
| » Major-league debuts: Hank Izquierdo (Twins) |
| Thursday, August 10 |
| » Lost to Twins (59-50), 5-0 | Metropolitan Stadium (3-6) | 56-57 | |
| » W: Jim Perry (4-5) L: Barry Moore (7-10) | Sixth | 7½ out |
| Friday, August 11 |
| » Lost to Athletics (50-64), 3-2 | Municipal Stadium (4-3) | 56-58 | Lost 2 |
| » W: Lew Krausse (6-14) L: Joe Coleman (8-9) | Sixth | 7½ out |
| Saturday, August 12 |
| » Defeated Athletics (50-65), 6-5 | Municipal Stadium (5-3) | 57-58 | |
| » W: Casey Cox (6-1) L: Jack Aker (3-6) S: Bob Priddy (3) | Sixth | 6½ out |
| Sunday, August 13 |
| » Defeated Athletics (50-66), 2-0 | Municipal Stadium (6-3) | 58-58 | Won 2 |
| » W: Frank Bertaina (3-3) L: Catfish Hunter (10-12) | Sixth | 6 out |
| Tuesday, August 15 |
| » Lost to Indians (55-62), 3-0 | Robert F. Kennedy Stadium (30-24) | 58-59 | |
| » W: Stan Williams (3-1) L: Darold Knowles (5-6) | Sixth | 7½ out |
| Wednesday, August 16 |
| » Lost to Indians (56-62), 1-0 | Robert F. Kennedy Stadium (30-25) | 58-60 | Lost 2 |
| » W: Steve Hargan (13-9) L: Camilo Pascual (11-9) | Sixth | 8½ out |
| Thursday, August 17 |
| » Lost to Indians (57-62), 8-3 | Robert F. Kennedy Stadium (30-26) | 58-61 | Lost 3 |
| » W: Ed Connolly (2-1) L: Dick Lines (1-3) | Sixth | 9 out |
| Friday, August 18 |
| » Defeated Athletics (51-69), 7-6 | Robert F. Kennedy Stadium (31-26) | 59-61 | |
| » W: Bob Humphreys (5-1) L: Paul Lindblad (5-7) | Sixth | 8½ out |
| Saturday, August 19 |
| » Lost to Athletics (52-69), 5-1 | Robert F. Kennedy Stadium (31-27) | 59-62 | |
| » W: Jim Nash (11-12) L: Dick Nold (0-1) S: Roberto Rodriguez (1) | Sixth | 9½ out |
| Monday, August 21 |
| » Lost to Red Sox (67-54), 6-5 | Fenway Park (2-3) | 59-63 | Lost 2 |
| » W: John Wyatt (7-5) L: Darold Knowles (5-7) | Fifth | 9½ out |
| Tuesday, August 22 |
| » Lost to Red Sox (68-54), 2-1 | Fenway Park (2-4) | 59-64 | Lost 3 |
| » W: Jerry Stephenson (1-0) L: Phil Ortega (9-6) S: John Wyatt (15) | Sixth | 10½ out |
| » Lost to Red Sox (69-54), 5-3 | Fenway Park (2-5) | 59-65 | Lost 4 |
| » W: Gary Bell (9-10) L: Casey Cox (6-2) S: Bucky Brandon (2) | Sixth | 10½ out |
| Wednesday, August 23 |
| » Defeated Red Sox (69-55), 3-2 | Fenway Park (3-5) | 60-65 | |
| » W: Bob Priddy (2-5) L: Sparky Lyle (1-2) | Sixth | 10½ out |
| Thursday, August 24 |
| » Lost to Red Sox (70-55), 7-5 | Fenway Park (3-6) | 60-66 | |
| » W: Dave Morehead (3-2) L: Dick Nold (0-2) S: John Wyatt (16) | Sixth | 10½ out |
| Friday, August 25 |
| » Lost to Yankees (56-70), 7-5 | Robert F. Kennedy Stadium (31-28) | 60-67 | Lost 2 |
| » W: Mel Stottlemyre (13-10) L: Frank Bertaina (3-4) S: Dooley Womack (10) | Sixth | 12 out |
| » Lost to Yankees (57-70), 2-1 | Robert F. Kennedy Stadium (31-29) | 60-68 | Lost 3 |
| » W: Joe Verbanic (4-2) L: Bob Humphreys (5-2) S: Dooley Womack (11) | Sixth | 12 out |
| Saturday, August 26 |
| » Defeated Yankees (57-71), 4-3 | Robert F. Kennedy Stadium (32-29) | 61-68 | |
| » W: Casey Cox (7-2) L: Steve Hamilton (2-4) | Sixth | 11½ out |
| Sunday, August 27 |
| » Lost to Yankees (58-71), 8-2 | Robert F. Kennedy Stadium (32-30) | 61-69 | |
| » W: Fritz Peterson (5-13) L: Phil Ortega (9-7) S: Dooley Womack (12) | Sixth | 12 out |
| Monday, August 28 |
| » Defeated White Sox (71-58), 2-1 | Robert F. Kennedy Stadium (33-30) | 62-69 | |
| » W: Bob Priddy (3-5) L: Joe Horlen (14-6) S: Dave Baldwin (11) | Sixth | 12 out |
| Tuesday, August 29 |
| » Defeated White Sox (71-59), 3-0 | Robert F. Kennedy Stadium (34-30) | 63-69 | Won 2 |
| » W: Dick Bosman (1-0) L: Tommy John (8-9) | Sixth | 11½ out |
| Wednesday, August 30 |
| » Lost to White Sox (72-59), 5-1 | Robert F. Kennedy Stadium (34-31) | 63-70 | |
| » W: Fred Klages (3-3) L: Camilo Pascual (11-10) S: Bob Locker (15) | Sixth | 12½ out |
| Thursday, August 31 |
| » Defeated Yankees (59-75), 6-0 | Yankee Stadium (2-4) | 64-70 | |
| » W: Frank Bertaina (4-4) L: Steve Barber (9-15) | Sixth | 11½ out |
| Friday, September 1 |
| » Lost to Yankees (60-75), 2-1 | Yankee Stadium (2-5) | 64-71 | |
| » W: Fritz Peterson (6-13) L: Dick Lines (1-4) | Sixth | 12½ out |
| Saturday, September 2 |
| » Lost to Yankees (61-75), 2-1 | Yankee Stadium (2-6) | 64-72 | Lost 2 |
| » W: Mel Stottlemyre (14-11) L: Bob Priddy (3-6) | Sixth | 13 out |
| Sunday, September 3 |
| » Defeated Yankees (61-76), 6-3 | Yankee Stadium (3-6) | 65-72 | |
| » W: Dick Bosman (2-0) L: Bill Monbouquette (3-4) | Sixth | 12 out |
| Monday, September 4 |
| » Defeated Red Sox (77-62), 5-2 | Robert F. Kennedy Stadium (35-31) | 66-72 | Won 2 |
| » W: Camilo Pascual (12-10) L: Dave Morehead (4-3) S: Darold Knowles (12) | Sixth | 12 out |
| » Lost to Red Sox (78-62), 6-4 | Robert F. Kennedy Stadium (35-32) | 66-73 | |
| » W: Jerry Stephenson (3-0) L: Dick Lines (1-5) S: John Wyatt (18) | Sixth | 12 out |
| Tuesday, September 5 |
| » Lost to Red Sox (79-62), 8-2 | Robert F. Kennedy Stadium (35-33) | 66-74 | Lost 2 |
| » W: Gary Bell (11-11) L: Frank Bertaina (4-5) | Sixth | 13 out |
| Friday, September 8 |
| » Lost to Angels (73-67), 4-0 | Robert F. Kennedy Stadium (35-34) | 66-75 | Lost 3 |
| » W: Rickey Clark (11-10) L: Phil Ortega (9-8) | Fifth | 13½ out |
| Saturday, September 9 |
| » Defeated Angels (73-68), 4-0 | Robert F. Kennedy Stadium (36-34) | 67-75 | |
| » W: Darold Knowles (6-7) L: Jim McGlothlin (11-6) | Fifth | 13½ out |
| Sunday, September 10 |
| » Defeated Angels (73-69), 3-2 | Robert F. Kennedy Stadium (37-34) | 68-75 | Won 2 |
| » W: Dick Lines (2-5) L: Minnie Rojas (10-9) | Sixth | 13½ out |
| » Major-league debuts: Frank Coggins (Senators) |
| Monday, September 11 |
| » Lost to Twins (83-62), 13-5 | Robert F. Kennedy Stadium (37-35) | 68-76 | |
| » W: Jim Perry (8-7) L: Casey Cox (7-3) | Sixth | 14½ out |
| Tuesday, September 12 |
| » Defeated Twins (83-63), 5-4 | Robert F. Kennedy Stadium (38-35) | 69-76 | |
| » W: Frank Bertaina (5-5) L: Jim Merritt (12-5) S: Darold Knowles (13) | Fifth | 13½ out |
| Wednesday, September 13 |
| » Lost to Twins (84-63), 3-2 | Robert F. Kennedy Stadium (38-36) | 69-77 | |
| » W: Jim Kaat (13-13) L: Phil Ortega (9-9) S: Dean Chance (1) | Fifth | 14½ out |
| Former Senator Joe Stanley dies in Detroit, MI at the age of 87. |
| Friday, September 15 |
| » Lost to Tigers (84-64), 5-4 | Tiger Stadium (2-5) | 69-78 | Lost 2 |
| » W: Fred Lasher (2-0) L: Casey Cox (7-4) | Fourth | 14½ out |
| Saturday, September 16 |
| » Lost to Tigers (85-64), 5-4 | Tiger Stadium (2-6) | 69-79 | Lost 3 |
| » W: Earl Wilson (21-10) L: Bob Priddy (3-7) S: Fred Lasher (8) | Fifth | 15½ out |
| Sunday, September 17 |
| » Defeated Tigers (85-65), 5-0 | Tiger Stadium (3-6) | 70-79 | |
| » W: Frank Bertaina (6-5) L: John Hiller (4-2) | Fifth | 14½ out |
| » Major-league debuts: Dave Campbell and Wayne Comer (Tigers) |
| Monday, September 18 |
| » Major-league debuts: Ken Boswell (Mets) John Duffie (Dodgers) |
| Tuesday, September 19 |
| » Lost to Indians (72-81), 2-0 | Cleveland Stadium (3-6) | 70-80 | |
| » W: Sonny Siebert (9-11) L: Phil Ortega (9-10) | Sixth | 15 out |
| Wednesday, September 20 |
| » Lost to Orioles (70-81), 4-3 | Robert F. Kennedy Stadium (38-37) | 70-81 | Lost 2 |
| » W: Tom Phoebus (14-8) L: Dick Bosman (2-1) S: Moe Drabowsky (12) | Seventh | 16½ out |
| » Lost to Orioles (71-81), 6-3 | Robert F. Kennedy Stadium (38-38) | 70-82 | Lost 3 |
| » W: Eddie Fisher (4-3) L: Darold Knowles (6-8) | Seventh | 16½ out |
| » Major-league debuts: Tom Fisher (Orioles) |
| Thursday, September 21 |
| » Defeated Orioles (71-82), 4-3 | Robert F. Kennedy Stadium (39-38) | 71-82 | |
| » W: Dave Baldwin (2-3) L: Stu Miller (2-10) | Sixth | 16½ out |
| » Major-league debuts: Dave Leonhard (Orioles) |
| Friday, September 22 |
| » Lost to Tigers (87-67), 8-3 | Robert F. Kennedy Stadium (39-39) | 71-83 | |
| » W: Earl Wilson (22-10) L: Frank Bertaina (6-6) | Eighth | 18 out |
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