| Wednesday, January 25 |
| Former Pirate George Gibson dies in London, ON at the age of 87. |
| Tuesday, February 7 |
| Former Pirate Joe Vitelli dies in Pittsburgh, PA at the age of 59. |
| Wednesday, March 8 |
| Future Pirate Joel Johnston is born in West Chester, PA. |
| Tuesday, April 11 |
| » Defeated Mets (0-1), 6-3 | Shea Stadium (1-0) | 1-0 | |
| » Starters: Bob Veale vs Don Cardwell | First | -- |
| » Major-league debuts: Don Shaw (Mets) |
| Thursday, April 13 |
| » Lost to Mets (1-1), 3-2 | Shea Stadium (1-1) | 1-1 | |
| » Starters: Woodie Fryman vs Tom Seaver | Fourth | 1 out |
| » Major-league debuts: Tom Seaver (Mets) |
| Friday, April 14 |
| » Lost to Cubs (2-1), 8-5 | Forbes Field (0-1) | 1-2 | Lost 2 |
| » Starters: Curt Simmons vs Dennis Ribant | Fourth | 1½ out |
| Saturday, April 15 |
| » Lost to Cubs (3-1), 7-3 | Forbes Field (0-2) | 1-3 | Lost 3 |
| » Starters: Ray Culp vs Tommie Sisk | Fifth | 2½ out |
| Sunday, April 16 |
| » Defeated Cubs (3-2), 6-5 | Forbes Field (1-2) | 2-3 | |
| » Starters: Fergie Jenkins vs Bob Veale | Sixth | 2½ out |
| » Major-league debuts: Joe Niekro (Cubs) |
| Monday, April 17 |
| » Lost to Mets (2-4), 9-6 | Forbes Field (1-3) | 2-4 | |
| » Starters: Don Cardwell vs Vern Law | Sixth | 3 out |
| Thursday, April 20 |
| » Major-league debuts: Clarence Jones (Cubs) |
| Friday, April 21 |
| » Defeated Cubs (4-4), 6-1 | Wrigley Field (1-0) | 3-4 | |
| » Starters: Bob Veale vs Ray Culp | Sixth | 3 out |
| Saturday, April 22 |
| Former Pirate Bill Salkeld dies in Los Angeles, CA at the age of 51. |
| Sunday, April 23 |
| » Lost to Cubs (5-4), 7-3 | Wrigley Field (1-1) | 3-5 | |
| » Starters: Juan Pizarro vs Fergie Jenkins | Fifth | 3½ out |
| Tuesday, April 25 |
| » Defeated Phillies (7-4), 7-3 | Forbes Field (2-3) | 4-5 | |
| » Starters: Jim Bunning vs Dennis Ribant | Sixth | 3 out |
| Thursday, April 27 |
| » Defeated Phillies (7-5), 5-4 | Forbes Field (3-3) | 5-5 | Won 2 |
| » Starters: Larry Jackson vs Woodie Fryman | Fifth | 4 out |
| Friday, April 28 |
| » Defeated Cardinals (9-5), 6-2 | Busch Stadium II (1-0) | 6-5 | Won 3 |
| » Starters: Bob Veale vs Ray Washburn | Third | 4 out |
| Sunday, April 30 |
| » Defeated Cardinals (9-6), 2-0 | Busch Stadium II (2-0) | 7-5 | Won 4 |
| » Starters: Juan Pizarro vs Larry Jaster | Third | 4 out |
| Monday, May 1 |
| » Defeated Cardinals (9-7), 8-5 | Busch Stadium II (3-0) | 8-5 | Won 5 |
| » Starters: Billy O'Dell vs Al Jackson | Second | 3½ out |
| Tuesday, May 2 |
| » Lost to Dodgers (7-10), 5-3 | Forbes Field (3-4) | 8-6 | |
| » Starters: Claude Osteen vs Vern Law | Third | 3½ out |
| Wednesday, May 3 |
| » Defeated Dodgers (7-11), 6-5 | Forbes Field (4-4) | 9-6 | |
| » Starters: Don Sutton vs Woodie Fryman | Third | 3½ out |
| Thursday, May 4 |
| » Defeated Dodgers (7-12), 9-3 | Forbes Field (5-4) | 10-6 | Won 2 |
| » Starters: Don Drysdale vs Bob Veale | Second | 3 out |
| Friday, May 5 |
| » Defeated Giants (9-11), 7-2 | Forbes Field (6-4) | 11-6 | Won 3 |
| » Starters: Bobby Bolin vs Tommie Sisk | Second | 3 out |
| Saturday, May 6 |
| » Defeated Giants (9-12), 6-5 | Forbes Field (7-4) | 12-6 | Won 4 |
| » Starters: Gaylord Perry vs Billy O'Dell | Second | 3 out |
| Monday, May 8 |
| » Lost to Cardinals (13-9), 6-5 | Forbes Field (7-5) | 12-7 | |
| » Starters: Ray Washburn vs Juan Pizarro | Second | 3 out |
| Tuesday, May 9 |
| » Lost to Cardinals (14-9), 6-3 | Forbes Field (7-6) | 12-8 | Lost 2 |
| » Starters: Steve Carlton vs Woodie Fryman | Third | 3 out |
| Wednesday, May 10 |
| » Defeated Cardinals (14-10), 4-1 | Forbes Field (8-6) | 13-8 | |
| » Starters: Dick Hughes vs Bob Veale | Second | 3 out |
| Thursday, May 11 |
| » Lost to Braves (14-11), 9-2 | Forbes Field (8-7) | 13-9 | |
| » Starters: Bob Bruce vs Tommie Sisk | Second | 2½ out |
| Friday, May 12 |
| » Defeated Braves (14-12), 5-2 | Forbes Field (9-7) | 14-9 | |
| » Starters: Pat Jarvis vs Billy O'Dell | Second | 2½ out |
| Saturday, May 13 |
| » Defeated Braves (14-13), 6-5 | Forbes Field (10-7) | 15-9 | Won 2 |
| » Starters: Denny Lemaster vs Juan Pizarro | Second | 2½ out |
| Sunday, May 14 |
| » Defeated Braves (14-14), 5-2 | Forbes Field (11-7) | 16-9 | Won 3 |
| » Starters: Dick Kelley vs Dennis Ribant | Second | 3 out |
| Former Pirate Vic Saier dies in E.Lansing, MI at the age of 77. |
| Monday, May 15 |
| » Lost to Reds (22-10), 8-7 | Crosley Field (0-1) | 16-10 | |
| » Starters: Bob Veale vs Milt Pappas | Second | 3 out |
| Tuesday, May 16 |
| » Lost to Reds (23-10), 6-3 | Crosley Field (0-2) | 16-11 | Lost 2 |
| » Starters: Woodie Fryman vs Mel Queen | Second | 4 out |
| Wednesday, May 17 |
| » Lost to Reds (24-10), 3-1 | Crosley Field (0-3) | 16-12 | Lost 3 |
| » Starters: Tommie Sisk vs Sammy Ellis | Third | 5 out |
| Thursday, May 18 |
| » Defeated Braves (16-15), 5-3 | Atlanta-Fulton County Stadium (1-0) | 17-12 | |
| » Starters: Billy O'Dell vs Pat Jarvis | Third | 4 out |
| Friday, May 19 |
| » Lost to Braves (17-15), 3-2 | Atlanta-Fulton County Stadium (1-1) | 17-13 | |
| » Starters: Dennis Ribant vs Denny Lemaster | Third | 5 out |
| Saturday, May 20 |
| » Defeated Braves (17-16), 6-2 | Atlanta-Fulton County Stadium (2-1) | 18-13 | |
| » Starters: Bob Veale vs Dick Kelley | Third | 5 out |
| Sunday, May 21 |
| » Lost to Braves (18-16), 7-2 | Atlanta-Fulton County Stadium (2-2) | 18-14 | |
| » Starters: Juan Pizarro vs Ken Johnson | Third | 5 out |
| Monday, May 22 |
| » Defeated Astros (11-26), 3-1 | Astrodome (1-0) | 19-14 | |
| » Starters: Tommie Sisk vs Chris Zachary | Third | 4½ out |
| Tuesday, May 23 |
| » Lost to Astros (12-26), 8-3 | Astrodome (1-1) | 19-15 | |
| » Starters: Billy O'Dell vs Larry Dierker | Third | 5 out |
| Wednesday, May 24 |
| » Defeated Astros (12-27), 7-4 | Astrodome (2-1) | 20-15 | |
| » Starters: Dennis Ribant vs Don Wilson | Third | 4½ out |
| Friday, May 26 |
| » Defeated Reds (27-15), 6-5 | Forbes Field (12-7) | 21-15 | Won 2 |
| » Starters: Gary Nolan vs Bob Veale | Third | 3 out |
| Saturday, May 27 |
| » Lost to Reds (28-15), 6-1 | Forbes Field (12-8) | 21-16 | |
| » Starters: Milt Pappas vs Juan Pizarro | Third | 4 out |
| Sunday, May 28 |
| » Defeated Reds (28-16), 3-2 | Forbes Field (13-8) | 22-16 | |
| » Starters: Sammy Ellis vs Tommie Sisk | Third | 3 out |
| Tuesday, May 30 |
| » Lost to Astros (15-27), 3-2 | Forbes Field (13-9) | 22-17 | |
| » Starters: Don Wilson vs Dennis Ribant | Third | 3½ out |
| » Defeated Astros (15-28), 4-3 | Forbes Field (14-9) | 23-17 | |
| » Starters: Larry Dierker vs Billy O'Dell | Third | 3½ out |
| Wednesday, May 31 |
| » Lost to Giants (24-19), 15-4 | Candlestick Park (0-1) | 23-18 | |
| » Starters: Bob Veale vs Mike McCormick | Third | 3½ out |
| Thursday, June 1 |
| » Lost to Giants (25-19), 7-1 | Candlestick Park (0-2) | 23-19 | Lost 2 |
| » Starters: Juan Pizarro vs Gaylord Perry | Fourth | 4½ out |
| Friday, June 2 |
| » Defeated Dodgers (19-26), 5-3 | Dodger Stadium (1-0) | 24-19 | |
| » Starters: Tommie Sisk vs Bill Singer | Fourth | 4½ out |
| Saturday, June 3 |
| » Lost to Dodgers (20-26), 5-1 | Dodger Stadium (1-1) | 24-20 | |
| » Starters: Billy O'Dell vs Don Sutton | Fourth | 5½ out |
| Sunday, June 4 |
| » Defeated Dodgers (20-27), 4-1 | Dodger Stadium (2-1) | 25-20 | |
| » Starters: Bob Veale vs Don Drysdale | Fourth | 5½ out |
| Tuesday, June 6 |
| » Lost to Mets (16-30), 1-0 | Forbes Field (14-10) | 25-21 | |
| » Starters: Tom Seaver vs Dennis Ribant | Fourth | 7 out |
| » Lost to Mets (17-30), 3-2 | Forbes Field (14-11) | 25-22 | Lost 2 |
| » Starters: Dick Selma vs Juan Pizarro | Fourth | 7 out |
| Wednesday, June 7 |
| » Defeated Mets (17-31), 3-0 | Forbes Field (15-11) | 26-22 | |
| » Starters: Jack Fisher vs Tommie Sisk | Fourth | 6 out |
| Friday, June 9 |
| » Defeated Phillies (24-26), 16-1 | Forbes Field (16-11) | 27-22 | Won 2 |
| » Starters: Rick Wise vs Billy O'Dell | Fourth | 5½ out |
| Saturday, June 10 |
| » Defeated Phillies (24-27), 4-3 | Forbes Field (17-11) | 28-22 | Won 3 |
| » Starters: Larry Jackson vs Bob Veale | Fourth | 5½ out |
| Sunday, June 11 |
| » Lost to Phillies (25-27), 14-1 | Forbes Field (17-12) | 28-23 | |
| » Starters: Jim Bunning vs Juan Pizarro | Fourth | 6 out |
| Monday, June 12 |
| » Defeated Cardinals (32-21), 7-5 | Forbes Field (18-12) | 29-23 | |
| » Starters: Steve Carlton vs Dennis Ribant | Fourth | 5½ out |
| Tuesday, June 13 |
| » Lost to Cardinals (33-21), 7-4 | Forbes Field (18-13) | 29-24 | |
| » Starters: Dick Hughes vs Tommie Sisk | Fourth | 6 out |
| Former Pirate Doug Baird dies in Thomasville, GA at the age of 76. |
| Wednesday, June 14 |
| » Lost to Cardinals (34-21), 7-4 | Forbes Field (18-14) | 29-25 | Lost 2 |
| » Starters: Bob Gibson vs Billy O'Dell | Fourth | 6 out |
| Thursday, June 15 |
| » Lost to Phillies (27-29), 4-1 | Shibe Park (0-1) | 29-26 | Lost 3 |
| » Starters: Bob Veale vs Dick Hall | Fourth | 6 out |
| » Defeated Phillies (27-30), 5-2 | Shibe Park (1-1) | 30-26 | |
| » Starters: Steve Blass vs Dick Ellsworth | Fourth | 6 out |
| Friday, June 16 |
| » Lost to Phillies (28-30), 5-3 | Shibe Park (1-2) | 30-27 | |
| » Starters: Billy O'Dell vs Larry Jackson | Fifth | 7 out |
| Future Pirate John Ericks is born in Tinley Park, IL. |
| Saturday, June 17 |
| » Defeated Phillies (28-31), 6-5 | Shibe Park (2-2) | 31-27 | |
| » Starters: Dennis Ribant vs Jim Bunning | Fifth | 6 out |
| Sunday, June 18 |
| » Defeated Phillies (28-32), 5-3 | Shibe Park (3-2) | 32-27 | Won 2 |
| » Starters: Tommie Sisk vs Rick Wise | Third | 4½ out |
| Monday, June 19 |
| » Defeated Cubs (32-28), 4-3 | Forbes Field (19-14) | 33-27 | Won 3 |
| » Starters: Fergie Jenkins vs Bob Veale | Third | 4½ out |
| Tuesday, June 20 |
| » Lost to Cubs (33-28), 5-3 | Forbes Field (19-15) | 33-28 | |
| » Starters: Joe Niekro vs Steve Blass | Fourth | 5½ out |
| Wednesday, June 21 |
| » Lost to Cubs (34-28), 6-3 | Forbes Field (19-16) | 33-29 | Lost 2 |
| » Starters: Curt Simmons vs Billy O'Dell | Fifth | 6½ out |
| Friday, June 23 |
| » Defeated Reds (41-28), 4-2 | Crosley Field (1-3) | 34-29 | |
| » Starters: Dennis Ribant vs Sammy Ellis | Fourth | 7 out |
| Saturday, June 24 |
| » Lost to Reds (42-28), 6-4 | Crosley Field (1-4) | 34-30 | |
| » Starters: Tommie Sisk vs Gary Nolan | Fourth | 8 out |
| Sunday, June 25 |
| » Defeated Reds (42-29), 5-4 | Crosley Field (2-4) | 35-30 | |
| » Starters: Bob Veale vs Milt Pappas | Fourth | 6½ out |
| Monday, June 26 |
| » Lost to Mets (24-41), 3-2 | Shea Stadium (1-2) | 35-31 | |
| » Starters: Steve Blass vs Bob Shaw | Fourth | 7½ out |
| Tuesday, June 27 |
| » Lost to Mets (25-41), 5-2 | Shea Stadium (1-3) | 35-32 | Lost 2 |
| » Starters: Tommie Sisk vs Dennis Bennett | Fourth | 7½ out |
| Future Pirate Lee Hancock is born in North Hollywood, CA. |
| Wednesday, June 28 |
| » Lost to Cubs (40-29), 4-2 | Wrigley Field (1-2) | 35-33 | Lost 3 |
| » Starters: Dennis Ribant vs Fergie Jenkins | Sixth | 8 out |
| » Lost to Cubs (41-29), 3-1 | Wrigley Field (1-3) | 35-34 | Lost 4 |
| » Starters: Tommie Sisk vs Ray Culp | Sixth | 8 out |
| Thursday, June 29 |
| » Lost to Cubs (42-29), 4-3 | Wrigley Field (1-4) | 35-35 | Lost 5 |
| » Starters: Al McBean vs Joe Niekro | Sixth | 8 out |
| Future Pirate John Wehner is born in Pittsburgh, PA. |
| Friday, June 30 |
| » Defeated Braves (37-36), 3-1 | Forbes Field (20-16) | 36-35 | |
| » Starters: Ken Johnson vs Steve Blass | Sixth | 8 out |
| Saturday, July 1 |
| » Lost to Braves (38-36), 4-2 | Forbes Field (20-17) | 36-36 | |
| » Starters: Pat Jarvis vs Bob Veale | Sixth | 8 out |
| Monday, July 3 |
| » Defeated Dodgers (33-43), 5-2 | Forbes Field (21-17) | 37-36 | |
| » Starters: Don Drysdale vs Tommie Sisk | Fifth | 8 out |
| Tuesday, July 4 |
| » Defeated Dodgers (33-44), 9-7 | Forbes Field (22-17) | 38-36 | Won 2 |
| » Starters: Claude Osteen vs Dennis Ribant | Sixth | 7 out |
| Wednesday, July 5 |
| » Lost to Dodgers (34-44), 5-3 | Forbes Field (22-18) | 38-37 | |
| » Starters: Don Sutton vs Steve Blass | Sixth | 7 out |
| Friday, July 7 |
| » Lost to Reds (46-37), 6-2 | Forbes Field (22-19) | 38-38 | Lost 2 |
| » Starters: Sammy Ellis vs Bob Veale | Sixth | 8½ out |
| Saturday, July 8 |
| » Defeated Reds (46-38), 6-1 | Forbes Field (23-19) | 39-38 | |
| » Starters: Gerry Arrigo vs Tommie Sisk | Sixth | 8½ out |
| Sunday, July 9 |
| » Defeated Reds (46-39), 2-1 | Forbes Field (24-19) | 40-38 | Won 2 |
| » Starters: Gary Nolan vs Dennis Ribant | Sixth | 7½ out |
| Wednesday, July 12 |
| » Lost to Cardinals (50-32), 4-3 | Busch Stadium II (3-1) | 40-39 | |
| » Starters: Steve Blass vs Dick Hughes | Sixth | 8½ out |
| Thursday, July 13 |
| » Defeated Cardinals (50-33), 8-5 | Busch Stadium II (4-1) | 41-39 | |
| » Starters: Bob Veale vs Steve Carlton | Sixth | 7½ out |
| Friday, July 14 |
| » Lost to Cardinals (51-33), 2-1 | Busch Stadium II (4-2) | 41-40 | |
| » Starters: Tommie Sisk vs Larry Jaster | Sixth | 8½ out |
| Saturday, July 15 |
| » Defeated Cardinals (51-34), 6-4 | Busch Stadium II (5-2) | 42-40 | |
| » Starters: Dennis Ribant vs Bob Gibson | Sixth | 7½ out |
| Sunday, July 16 |
| » Lost to Braves (45-39), 2-1 | Atlanta-Fulton County Stadium (2-3) | 42-41 | |
| » Starters: Vern Law vs Phil Niekro | Sixth | 7 out |
| Monday, July 17 |
| » Lost to Braves (46-39), 6-2 | Atlanta-Fulton County Stadium (2-4) | 42-42 | Lost 2 |
| » Starters: Bob Veale vs Ken Johnson | Sixth | 8 out |
| Tuesday, July 18 |
| » Defeated Giants (47-43), 8-6 | Forbes Field (25-19) | 43-42 | |
| » Manager: Danny Murtaugh |
| » Starters: Juan Marichal vs Steve Blass | Sixth | 7½ out |
| » Lost to Giants (48-43), 3-2 | Forbes Field (25-20) | 43-43 | |
| » Starters: Joe Gibbon vs Tommie Sisk | Sixth | 7½ out |
| Wednesday, July 19 |
| » Defeated Giants (48-44), 2-1 | Forbes Field (26-20) | 44-43 | |
| » Starters: Mike McCormick vs Dennis Ribant | Sixth | 7½ out |
| Thursday, July 20 |
| » Lost to Giants (49-44), 6-1 | Forbes Field (26-21) | 44-44 | |
| » Starters: Gaylord Perry vs Vern Law | Sixth | 8½ out |
| Friday, July 21 |
| » Defeated Astros (37-56), 9-1 | Forbes Field (27-21) | 45-44 | |
| » Starters: Wade Blasingame vs Bob Veale | Sixth | 7½ out |
| Saturday, July 22 |
| » Defeated Astros (37-57), 15-2 | Forbes Field (28-21) | 46-44 | Won 2 |
| » Starters: Bo Belinsky vs Woodie Fryman | Fifth | 6½ out |
| Sunday, July 23 |
| » Lost to Astros (38-57), 8-5 | Forbes Field (28-22) | 46-45 | |
| » Starters: Dave Giusti vs Steve Blass | Sixth | 7½ out |
| » Defeated Astros (38-58), 15-2 | Forbes Field (29-22) | 47-45 | |
| » Starters: Barry Latman vs Tommie Sisk | Sixth | 7½ out |
| » Major-league debuts: Manny Sanguillen (Pirates) |
| Monday, July 24 |
| » Lost to Dodgers (41-53), 4-3 | Dodger Stadium (2-2) | 47-46 | |
| » Starters: Dennis Ribant vs Claude Osteen | Fifth | 7½ out |
| Tuesday, July 25 |
| » Lost to Dodgers (42-53), 3-1 | Dodger Stadium (2-3) | 47-47 | Lost 2 |
| » Starters: Vern Law vs Bill Singer | Sixth | 8½ out |
| Future Pirate Ed Sprague is born in Castro Valley, CA. |
| Wednesday, July 26 |
| » Defeated Dodgers (42-54), 4-2 | Dodger Stadium (3-3) | 48-47 | |
| » Starters: Bob Veale vs Don Sutton | Sixth | 8½ out |
| Thursday, July 27 |
| » Lost to Astros (41-59), 5-4 | Astrodome (2-2) | 48-48 | |
| » Starters: Woodie Fryman vs Bo Belinsky | Sixth | 9 out |
| Friday, July 28 |
| » Lost to Astros (42-59), 9-3 | Astrodome (2-3) | 48-49 | Lost 2 |
| » Starters: Tommie Sisk vs Dave Giusti | Sixth | 10 out |
| Saturday, July 29 |
| » Lost to Astros (43-59), 6-5 | Astrodome (2-4) | 48-50 | Lost 3 |
| » Starters: Dennis Ribant vs Mike Cuellar | Sixth | 11 out |
| Sunday, July 30 |
| » Defeated Giants (53-50), 4-3 | Candlestick Park (1-2) | 49-50 | |
| » Starters: Vern Law vs Ray Sadecki | Sixth | 11 out |
| Monday, July 31 |
| » Lost to Giants (54-50), 8-4 | Candlestick Park (1-3) | 49-51 | |
| » Starters: Tommie Sisk vs Mike McCormick | Sixth | 12 out |
| Tuesday, August 1 |
| » Lost to Giants (55-50), 3-1 | Candlestick Park (1-4) | 49-52 | Lost 2 |
| » Starters: Woodie Fryman vs Juan Marichal | Seventh | 12 out |
| Wednesday, August 2 |
| » Lost to Giants (56-50), 7-2 | Candlestick Park (1-5) | 49-53 | Lost 3 |
| » Starters: Dennis Ribant vs Gaylord Perry | Seventh | 13½ out |
| Friday, August 4 |
| » Defeated Dodgers (46-58), 3-2 | Forbes Field (30-22) | 50-53 | |
| » Starters: Don Sutton vs Bob Veale | Seventh | 13½ out |
| Future Pirate Steve Bieser is born in Perryville, MO. |
| Saturday, August 5 |
| » Defeated Dodgers (46-59), 2-1 | Forbes Field (31-22) | 51-53 | Won 2 |
| » Starters: Phil Regan vs Vern Law | Seventh | 13½ out |
| Sunday, August 6 |
| » Lost to Dodgers (47-59), 5-4 | Forbes Field (31-23) | 51-54 | |
| » Starters: Claude Osteen vs Tommie Sisk | Seventh | 14½ out |
| Monday, August 7 |
| » Defeated Cubs (59-52), 6-3 | Wrigley Field (2-4) | 52-54 | |
| » Starters: Woodie Fryman vs Bob Shaw | Seventh | 13½ out |
| » Tied Cubs, 3-3 | Wrigley Field (2-4) | 52-54 | |
| » Starters: Dennis Ribant vs Bill Hands | Seventh | 13½ out |
| Tuesday, August 8 |
| » Lost to Cubs (60-52), 8-4 | Wrigley Field (2-5) | 52-55 | |
| » Starters: John Gelnar vs Joe Niekro | Seventh | 13½ out |
| Wednesday, August 9 |
| » Lost to Cubs (61-52), 6-0 | Wrigley Field (2-6) | 52-56 | Lost 2 |
| » Starters: Bob Veale vs Fergie Jenkins | Seventh | 14 out |
| » Defeated Cubs (61-53), 10-6 | Wrigley Field (3-6) | 53-56 | |
| » Starters: Vern Law vs Ray Culp | Seventh | 14 out |
| Thursday, August 10 |
| » Defeated Mets (42-66), 3-0 | Shea Stadium (2-3) | 54-56 | Won 2 |
| » Starters: Tommie Sisk vs Jack Fisher | Seventh | 13 out |
| Friday, August 11 |
| » Lost to Mets (43-66), 3-2 | Shea Stadium (2-4) | 54-57 | |
| » Starters: Dennis Ribant vs Danny Frisella | Seventh | 14 out |
| Saturday, August 12 |
| » Lost to Mets (44-66), 6-1 | Shea Stadium (2-5) | 54-58 | Lost 2 |
| » Starters: Woodie Fryman vs Cal Koonce | Seventh | 15 out |
| Sunday, August 13 |
| » Lost to Mets (45-66), 3-0 | Shea Stadium (2-6) | 54-59 | Lost 3 |
| » Starters: Steve Blass vs Tom Seaver | Seventh | 16½ out |
| » Lost to Mets (46-66), 11-9 | Shea Stadium (2-7) | 54-60 | Lost 4 |
| » Starters: Vern Law vs Bob Hendley | Seventh | 16½ out |
| Monday, August 14 |
| » Defeated Reds (62-55), 4-3 | Forbes Field (32-23) | 55-60 | |
| » Starters: Gary Nolan vs Bob Veale | Seventh | 16½ out |
| Tuesday, August 15 |
| » Lost to Reds (63-55), 2-1 | Forbes Field (32-24) | 55-61 | |
| » Starters: Mel Queen vs Tommie Sisk | Seventh | 17½ out |
| Wednesday, August 16 |
| » Lost to Reds (64-55), 4-0 | Forbes Field (32-25) | 55-62 | Lost 2 |
| » Starters: Jim Maloney vs Woodie Fryman | Seventh | 18½ out |
| Thursday, August 17 |
| » Lost to Mets (49-68), 6-5 | Forbes Field (32-26) | 55-63 | Lost 3 |
| » Starters: Tom Seaver vs Steve Blass | Seventh | 18½ out |
| » Defeated Mets (49-69), 6-5 | Forbes Field (33-26) | 56-63 | |
| » Starters: Billy Wynne vs Dennis Ribant | Seventh | 18½ out |
| Friday, August 18 |
| » Defeated Mets (49-70), 7-2 | Forbes Field (34-26) | 57-63 | Won 2 |
| » Starters: Jack Fisher vs Bob Veale | Seventh | 18½ out |
| Saturday, August 19 |
| » Defeated Mets (49-71), 6-5 | Forbes Field (35-26) | 58-63 | Won 3 |
| » Starters: Danny Frisella vs Tommie Sisk | Seventh | 18½ out |
| Sunday, August 20 |
| » Defeated Mets (49-72), 4-2 | Forbes Field (36-26) | 59-63 | Won 4 |
| » Starters: Bob Hendley vs Vern Law | Seventh | 17½ out |
| Monday, August 21 |
| » Defeated Cubs (67-60), 5-1 | Forbes Field (37-26) | 60-63 | Won 5 |
| » Starters: Fergie Jenkins vs Woodie Fryman | Seventh | 16½ out |
| Tuesday, August 22 |
| » Lost to Cubs (68-60), 8-1 | Forbes Field (37-27) | 60-64 | |
| » Starters: Joe Niekro vs Bob Veale | Seventh | 17½ out |
| Wednesday, August 23 |
| » Defeated Cubs (68-61), 2-1 | Forbes Field (38-27) | 61-64 | |
| » Starters: Bill Hands vs Al McBean | Seventh | 16½ out |
| Friday, August 25 |
| » Lost to Phillies (64-59), 2-0 | Shibe Park (3-3) | 61-65 | |
| » Starters: Tommie Sisk vs Jim Bunning | Seventh | 18 out |
| » Lost to Phillies (65-59), 6-2 | Shibe Park (3-4) | 61-66 | Lost 2 |
| » Starters: Steve Blass vs Chris Short | Seventh | 18 out |
| Saturday, August 26 |
| » Lost to Phillies (66-59), 1-0 | Shibe Park (3-5) | 61-67 | Lost 3 |
| » Starters: Bob Veale vs Rick Wise | Seventh | 18 out |
| Sunday, August 27 |
| » Lost to Phillies (67-59), 2-0 | Shibe Park (3-6) | 61-68 | Lost 4 |
| » Starters: Woodie Fryman vs Larry Jackson | Seventh | 19 out |
| Monday, August 28 |
| » Defeated Braves (65-63), 4-3 | Atlanta-Fulton County Stadium (3-4) | 62-68 | |
| » Starters: Al McBean vs Pat Jarvis | Sixth | 18½ out |
| Tuesday, August 29 |
| » Lost to Braves (66-63), 7-3 | Atlanta-Fulton County Stadium (3-5) | 62-69 | |
| » Starters: Tommie Sisk vs Phil Niekro | Sixth | 18½ out |
| Wednesday, August 30 |
| » Defeated Braves (66-64), 11-9 | Atlanta-Fulton County Stadium (4-5) | 63-69 | |
| » Starters: Steve Blass vs Tony Cloninger | Seventh | 18½ out |
| Thursday, August 31 |
| » Defeated Phillies (68-62), 6-4 | Forbes Field (39-27) | 64-69 | Won 2 |
| » Starters: Rick Wise vs Bob Veale | Seventh | 18½ out |
| Friday, September 1 |
| » Defeated Phillies (68-63), 3-0 | Forbes Field (40-27) | 65-69 | Won 3 |
| » Starters: Larry Jackson vs Woodie Fryman | Seventh | 18½ out |
| Saturday, September 2 |
| » Defeated Phillies (68-64), 9-1 | Forbes Field (41-27) | 66-69 | Won 4 |
| » Starters: Jim Bunning vs Al McBean | Seventh | 18½ out |
| Sunday, September 3 |
| » Lost to Phillies (69-64), 7-2 | Forbes Field (41-28) | 66-70 | |
| » Starters: Chris Short vs Tommie Sisk | Sixth | 19½ out |
| » Major-league debuts: Bruce Dal Canton (Pirates) |
| Monday, September 4 |
| » Defeated Cardinals (86-52), 10-8 | Busch Stadium II (6-2) | 67-70 | |
| » Starters: Bob Veale vs Larry Jaster | Sixth | 17½ out |
| » Defeated Cardinals (86-53), 9-3 | Busch Stadium II (7-2) | 68-70 | Won 2 |
| » Starters: Steve Blass vs Ray Washburn | Sixth | 17½ out |
| Wednesday, September 6 |
| » Lost to Braves (72-66), 4-1 | Forbes Field (41-29) | 68-71 | |
| » Starters: Denny Lemaster vs Woodie Fryman | Seventh | 18 out |
| » Defeated Braves (72-67), 4-1 | Forbes Field (42-29) | 69-71 | |
| » Starters: Pat Jarvis vs Al McBean | Seventh | 18 out |
| Thursday, September 7 |
| » Defeated Braves (72-68), 4-2 | Forbes Field (43-29) | 70-71 | Won 2 |
| » Starters: Phil Niekro vs Tommie Sisk | Seventh | 18 out |
| Friday, September 8 |
| » Defeated Cardinals (88-54), 4-3 | Forbes Field (44-29) | 71-71 | Won 3 |
| » Starters: Dick Hughes vs Dennis Ribant | Seventh | 17 out |
| Saturday, September 9 |
| » Lost to Cardinals (89-54), 6-0 | Forbes Field (44-30) | 71-72 | |
| » Starters: Steve Carlton vs Steve Blass | Seventh | 18 out |
| Sunday, September 10 |
| » Defeated Cardinals (89-55), 8-7 | Forbes Field (45-30) | 72-72 | |
| » Starters: Ray Washburn vs Woodie Fryman | Seventh | 17 out |
| » Major-league debuts: Mike Torrez (Cardinals) |
| Monday, September 11 |
| » Lost to Reds (79-66), 4-3 | Crosley Field (2-5) | 72-73 | |
| » Starters: Al McBean vs Milt Pappas | Seventh | 18 out |
| Tuesday, September 12 |
| » Lost to Reds (80-66), 15-7 | Crosley Field (2-6) | 72-74 | Lost 2 |
| » Starters: Bob Veale vs Bob Lee | Seventh | 19 out |
| Wednesday, September 13 |
| » Defeated Reds (80-67), 11-3 | Crosley Field (3-6) | 73-74 | |
| » Starters: Tommie Sisk vs Mel Queen | Seventh | 18 out |
| Thursday, September 14 |
| » Major-league debuts: Cito Gaston (Braves) |
| Friday, September 15 |
| » Lost to Giants (81-66), 6-3 | Forbes Field (45-31) | 73-75 | |
| » Starters: Gaylord Perry vs Steve Blass | Seventh | 19 out |
| Future Pirate Dennis Moeller is born in Tarzana, CA. |
| Saturday, September 16 |
| » Defeated Giants (81-67), 5-4 | Forbes Field (46-31) | 74-75 | |
| » Starters: Ron Herbel vs Woodie Fryman | Seventh | 19 out |
| Former Pirate Lee King dies in Shinnston, WV at the age of 75. |
| Sunday, September 17 |
| » Defeated Giants (81-68), 5-4 | Forbes Field (47-31) | 75-75 | Won 2 |
| » Starters: Ray Sadecki vs Al McBean | Sixth | 19 out |
| Monday, September 18 |
| » Lost to Astros (62-88), 14-4 | Astrodome (2-5) | 75-76 | |
| » Starters: Tommie Sisk vs Dave Giusti | Sixth | 20 out |
| » Major-league debuts: Bob Robertson (Pirates) |
| Tuesday, September 19 |
| » Defeated Astros (62-89), 11-7 | Astrodome (3-5) | 76-76 | |
| » Starters: Bob Moose vs Bruce Von Hoff | Sixth | 20 out |
| » Major-league debuts: Bob Moose (Pirates) |
| Wednesday, September 20 |
| » Lost to Astros (63-89), 5-4 | Astrodome (3-6) | 76-77 | |
| » Starters: Bruce Dal Canton vs Howie Reed | Sixth | 20 out |
| Friday, September 22 |
| » Lost to Giants (84-68), 1-0 | Candlestick Park (1-6) | 76-78 | Lost 2 |
| » Starters: Al McBean vs Ray Sadecki | Sixth | 20½ out |
| Saturday, September 23 |
| » Lost to Giants (85-68), 8-4 | Candlestick Park (1-7) | 76-79 | Lost 3 |
| » Starters: Woodie Fryman vs Mike McCormick | |
