| Sunday, March 26 |
| Future Oriole Jarvis Brown is born in Waukegan, IL. |
| Tuesday, March 28 |
| Future Oriole Shawn Boskie is born in Hawthorne, NV. |
| Tuesday, April 11 |
| » Defeated Twins (0-1), 6-3 | Memorial Stadium (1-0) | 1-0 | |
| » W: Moe Drabowsky (1-0) L: Jim Kaat (0-1) S: Stu Miller (1) | First | -- |
| » Major-league debuts: Rod Carew (Twins) |
| Thursday, April 13 |
| » Defeated Twins (0-2), 7-1 | Memorial Stadium (2-0) | 2-0 | Won 2 |
| » W: Jim Palmer (1-0) L: Dean Chance (0-1) | First | -- |
| Friday, April 14 |
| » Defeated Athletics (1-1), 7-1 | Municipal Stadium (1-0) | 3-0 | Won 3 |
| » W: Bill Dillman (1-0) L: Lew Krausse (0-1) | First | -- |
| » Major-league debuts: Bill Dillman (Orioles) |
| Future Oriole Mike Trombley is born in Springfield, MA. |
| Saturday, April 15 |
| » Lost to Athletics (2-1), 11-3 | Municipal Stadium (1-1) | 3-1 | |
| » W: Catfish Hunter (1-0) L: Wally Bunker (0-1) | First | -- |
| Sunday, April 16 |
| » Lost to Angels (3-2), 5-4 | Anaheim Stadium (0-1) | 3-2 | Lost 2 |
| » W: Lew Burdette (1-0) L: Stu Miller (0-1) | First | -- |
| » Defeated Angels (3-3), 3-0 | Anaheim Stadium (1-1) | 4-2 | |
| » W: Steve Barber (1-0) L: Jorge Rubio (0-1) | First | -- |
| Wednesday, April 19 |
| » Lost to Twins (2-4), 3-2 | Metropolitan Stadium (0-1) | 4-3 | |
| » W: Dean Chance (1-1) L: Stu Miller (0-2) | Third | ½ out |
| Friday, April 21 |
| » Lost to Athletics (4-4), 3-1 | Memorial Stadium (2-1) | 4-4 | Lost 2 |
| » W: Catfish Hunter (2-0) L: Tom Phoebus (0-1) S: Jack Aker (2) | Fourth | 1½ out |
| Saturday, April 22 |
| » Defeated Athletics (4-5), 12-2 | Memorial Stadium (3-1) | 5-4 | |
| » W: Wally Bunker (1-1) L: Blue Moon Odom (0-2) S: Bill Dillman (1) | Second | ½ out |
| Sunday, April 23 |
| » Defeated Athletics (4-6), 5-2 | Memorial Stadium (4-1) | 6-4 | Won 2 |
| » W: Steve Barber (2-0) L: Jim Nash (1-2) S: Stu Miller (2) | Third | ½ out |
| » Lost to Athletics (5-6), 8-7 | Memorial Stadium (4-2) | 6-5 | |
| » W: Jack Aker (2-0) L: Eddie Fisher (0-1) | Third | ½ out |
| Tuesday, April 25 |
| » Defeated Angels (7-6), 2-1 | Memorial Stadium (5-2) | 7-5 | |
| » W: Tom Phoebus (1-1) L: George Brunet (1-2) S: Stu Miller (3) | Second | 1 out |
| Friday, April 28 |
| » Defeated Tigers (7-6), 5-3 | Memorial Stadium (6-2) | 8-5 | Won 2 |
| » W: Dave McNally (1-0) L: Denny McLain (2-2) S: Moe Drabowsky (1) | First | -- |
| Saturday, April 29 |
| » Lost to Tigers (8-6), 4-2 | Memorial Stadium (6-3) | 8-6 | |
| » W: Mickey Lolich (2-1) L: Wally Bunker (1-2) | Second | ½ out |
| Sunday, April 30 |
| » Lost to Tigers (9-6), 2-1 | Memorial Stadium (6-4) | 8-7 | Lost 2 |
| » W: Earl Wilson (2-2) L: Steve Barber (2-1) S: Fred Gladding (2) | Fifth | 2 out |
| » Lost to Tigers (10-6), 6-4 | Memorial Stadium (6-5) | 8-8 | Lost 3 |
| » W: Joe Sparma (2-0) L: Jim Palmer (1-1) S: Dave Wickersham (1) | Fifth | 2 out |
| Monday, May 1 |
| » Defeated Indians (7-9), 8-7 | Cleveland Stadium (1-0) | 9-8 | |
| » W: Eddie Fisher (1-1) L: Bob Allen (0-2) | Fourth | 1½ out |
| Wednesday, May 3 |
| » Lost to Indians (8-9), 5-1 | Cleveland Stadium (1-1) | 9-9 | |
| » W: Sonny Siebert (2-1) L: Dave McNally (1-1) | Third | 1½ out |
| Friday, May 5 |
| » Lost to Tigers (11-7), 4-0 | Tiger Stadium (0-1) | 9-10 | Lost 2 |
| » W: Mickey Lolich (3-1) L: Steve Barber (2-2) | Sixth | 2½ out |
| Saturday, May 6 |
| » Lost to Tigers (12-7), 4-1 | Tiger Stadium (0-2) | 9-11 | Lost 3 |
| » W: Earl Wilson (3-2) L: Stu Miller (0-3) | Sixth | 3½ out |
| Sunday, May 7 |
| » Lost to Tigers (13-7), 4-0 | Tiger Stadium (0-3) | 9-12 | Lost 4 |
| » W: Joe Sparma (3-0) L: Dave McNally (1-2) | Eighth | 4½ out |
| Tuesday, May 9 |
| » Lost to White Sox (13-7), 5-4 | Memorial Stadium (6-6) | 9-13 | Lost 5 |
| » W: Gary Peters (3-1) L: Eddie Watt (0-1) S: Bob Locker (4) | Eighth | 5½ out |
| Wednesday, May 10 |
| » Lost to White Sox (14-7), 13-1 | Memorial Stadium (6-7) | 9-14 | Lost 6 |
| » W: Tommy John (2-2) L: Steve Barber (2-3) | Ninth | 6½ out |
| Friday, May 12 |
| » Defeated Yankees (11-12), 14-0 | Yankee Stadium (1-0) | 10-14 | |
| » W: Jim Palmer (2-1) L: Whitey Ford (2-3) | Ninth | 6½ out |
| » Major-league debuts: Frank Tepedino (Yankees) |
| Saturday, May 13 |
| » Defeated Yankees (11-13), 5-3 | Yankee Stadium (2-0) | 11-14 | Won 2 |
| » W: Moe Drabowsky (2-0) L: Al Downing (3-2) S: Eddie Watt (1) | Sixth | 6½ out |
| Sunday, May 14 |
| » Lost to Yankees (12-13), 6-5 | Yankee Stadium (2-1) | 11-15 | |
| » W: Dooley Womack (3-2) L: Stu Miller (0-4) | Seventh | 7½ out |
| Tuesday, May 16 |
| » Defeated Red Sox (13-15), 8-5 | Fenway Park (1-0) | 12-15 | |
| » W: Eddie Fisher (2-1) L: John Wyatt (2-2) S: Stu Miller (4) | Seventh | 6½ out |
| Wednesday, May 17 |
| » Defeated Red Sox (13-16), 12-8 | Fenway Park (2-0) | 13-15 | Won 2 |
| » W: Bill Dillman (2-0) L: Galen Cisco (0-1) S: Moe Drabowsky (2) | Fifth | 6½ out |
| Thursday, May 18 |
| » Lost to Senators (14-16), 2-0 | Robert F. Kennedy Stadium (0-1) | 13-16 | |
| » W: Pete Richert (2-5) L: Frank Bertaina (0-1) | Sixth | 7 out |
| Friday, May 19 |
| » Defeated Senators (14-17), 11-5 | Robert F. Kennedy Stadium (1-1) | 14-16 | |
| » W: Steve Barber (3-3) L: Phil Ortega (1-4) S: Wally Bunker (1) | Fourth | 7 out |
| Saturday, May 20 |
| » Defeated Senators (14-18), 4-3 | Robert F. Kennedy Stadium (2-1) | 15-16 | Won 2 |
| » W: Dave McNally (2-2) L: Joe Coleman (2-3) S: Moe Drabowsky (3) | Fourth | 6 out |
| Monday, May 22 |
| » Defeated Yankees (14-18), 7-0 | Memorial Stadium (7-7) | 16-16 | Won 3 |
| » W: Tom Phoebus (2-1) L: Fred Talbot (1-2) | Third | 5 out |
| Tuesday, May 23 |
| » Defeated Yankees (14-19), 1-0 | Memorial Stadium (8-7) | 17-16 | Won 4 |
| » W: Frank Bertaina (1-1) L: Mel Stottlemyre (3-4) S: Eddie Watt (2) | Third | 4½ out |
| Wednesday, May 24 |
| » Lost to Yankees (15-19), 2-0 | Memorial Stadium (8-8) | 17-17 | |
| » W: Al Downing (4-3) L: Steve Barber (3-4) | Fourth | 5½ out |
| Friday, May 26 |
| » Defeated Red Sox (18-19), 4-3 | Memorial Stadium (9-8) | 18-17 | |
| » W: Moe Drabowsky (3-0) L: Billy Rohr (2-2) | Third | 5 out |
| Future Oriole Stacy Jones is born in Gadsden, AL. |
| Saturday, May 27 |
| » Defeated Red Sox (18-20), 10-0 | Memorial Stadium (10-8) | 19-17 | Won 2 |
| » W: Tom Phoebus (3-1) L: Bucky Brandon (1-5) | Third | 5 out |
| Sunday, May 28 |
| » Lost to Red Sox (19-20), 4-3 | Memorial Stadium (10-9) | 19-18 | |
| » W: Jim Lonborg (6-1) L: Steve Barber (3-5) S: John Wyatt (3) | Third | 5 out |
| Tuesday, May 30 |
| » Defeated Indians (19-20), 5-4 | Memorial Stadium (11-9) | 20-18 | |
| » W: Dave McNally (3-2) L: Steve Hargan (6-4) S: Eddie Watt (3) | Third | 5½ out |
| » Lost to Indians (20-20), 3-2 | Memorial Stadium (11-10) | 20-19 | |
| » W: Sam McDowell (3-2) L: Wally Bunker (1-3) | Third | 5½ out |
| Wednesday, May 31 |
| » Lost to White Sox (25-15), 3-2 | Comiskey Park I (0-1) | 20-20 | Lost 2 |
| » W: Hoyt Wilhelm (2-0) L: Eddie Watt (0-2) | Fifth | 5½ out |
| Friday, June 2 |
| » Defeated Senators (20-24), 12-0 | Memorial Stadium (12-10) | 21-20 | |
| » W: Tom Phoebus (4-1) L: Darold Knowles (3-3) | Fifth | 5 out |
| Saturday, June 3 |
| » Defeated Senators (20-25), 3-2 | Memorial Stadium (13-10) | 22-20 | Won 2 |
| » W: Moe Drabowsky (4-0) L: Darold Knowles (3-4) | Fourth | 4 out |
| Sunday, June 4 |
| » Defeated Senators (20-26), 7-5 | Memorial Stadium (14-10) | 23-20 | Won 3 |
| » W: Stu Miller (1-4) L: Bob Priddy (0-3) | Third | 3½ out |
| Monday, June 5 |
| » Lost to Angels (20-30), 3-2 | Anaheim Stadium (1-2) | 23-21 | |
| » W: Bill Kelso (3-1) L: Dave McNally (3-3) | Third | 4½ out |
| Tuesday, June 6 |
| » Defeated Angels (20-31), 16-4 | Anaheim Stadium (2-2) | 24-21 | |
| » W: Bill Dillman (3-0) L: Pete Cimino (2-2) S: Moe Drabowsky (4) | Third | 4½ out |
| » Defeated Angels (20-32), 11-1 | Anaheim Stadium (3-2) | 25-21 | Won 2 |
| » W: Tom Phoebus (5-1) L: Rickey Clark (2-6) | Third | 4½ out |
| Wednesday, June 7 |
| » Lost to Angels (21-32), 2-0 | Anaheim Stadium (3-3) | 25-22 | |
| » W: Jim McGlothlin (6-1) L: Pete Richert (2-7) | Third | 4½ out |
| Thursday, June 8 |
| » Lost to Angels (22-32), 6-5 | Anaheim Stadium (3-4) | 25-23 | Lost 2 |
| » W: Pete Cimino (3-2) L: Stu Miller (1-5) S: Minnie Rojas (3) | Third | 5 out |
| Friday, June 9 |
| » Defeated Twins (25-26), 11-2 | Metropolitan Stadium (1-1) | 26-23 | |
| » W: Moe Drabowsky (5-0) L: Dean Chance (9-3) | Third | 4 out |
| Saturday, June 10 |
| » Lost to Twins (26-26), 8-1 | Metropolitan Stadium (1-2) | 26-24 | |
| » W: Jim Kaat (2-7) L: Tom Phoebus (5-2) | Third | 4 out |
| Sunday, June 11 |
| » Defeated Twins (26-27), 5-2 | Metropolitan Stadium (2-2) | 27-24 | |
| » W: Bill Dillman (4-0) L: Dave Boswell (3-4) | Third | 4½ out |
| » Lost to Twins (27-27), 10-7 | Metropolitan Stadium (2-3) | 27-25 | |
| » W: Jim Perry (2-4) L: Eddie Watt (0-3) S: Al Worthington (8) | Third | 4½ out |
| Monday, June 12 |
| » Defeated Athletics (26-31), 10-2 | Municipal Stadium (2-1) | 28-25 | |
| » W: Pete Richert (3-7) L: Lew Krausse (3-9) | Third | 3½ out |
| Tuesday, June 13 |
| » Lost to Athletics (27-31), 1-0 | Municipal Stadium (2-2) | 28-26 | |
| » W: Catfish Hunter (6-4) L: Steve Barber (3-6) | Third | 4½ out |
| Wednesday, June 14 |
| » Lost to Athletics (28-31), 9-2 | Municipal Stadium (2-3) | 28-27 | Lost 2 |
| » W: Chuck Dobson (4-2) L: Dave McNally (3-4) S: Jack Aker (7) | Fourth | 5 out |
| Thursday, June 15 |
| » Lost to Athletics (29-31), 6-5 | Municipal Stadium (2-4) | 28-28 | Lost 3 |
| » W: Diego Segui (1-2) L: Eddie Watt (0-4) | Fourth | 5 out |
| Friday, June 16 |
| » Lost to Angels (29-33), 2-1 | Memorial Stadium (14-11) | 28-29 | Lost 4 |
| » W: Minnie Rojas (6-5) L: Pete Richert (3-8) | Sixth | 6 out |
| » Lost to Angels (30-33), 5-3 | Memorial Stadium (14-12) | 28-30 | Lost 5 |
| » W: Ken Turner (1-0) L: Bill Dillman (4-1) | Sixth | 6 out |
| Saturday, June 17 |
| » Defeated Angels (30-34), 7-5 | Memorial Stadium (15-12) | 29-30 | |
| » W: Steve Barber (4-6) L: George Brunet (3-10) S: Eddie Watt (4) | Fifth | 6 out |
| Sunday, June 18 |
| » Lost to Angels (31-34), 5-3 | Memorial Stadium (15-13) | 29-31 | |
| » W: Rickey Clark (4-6) L: Dave McNally (3-5) S: Minnie Rojas (5) | Seventh | 7½ out |
| Monday, June 19 |
| » Lost to Twins (32-30), 4-0 | Memorial Stadium (15-14) | 29-32 | Lost 2 |
| » W: Dave Boswell (4-4) L: Tom Phoebus (5-3) | Fifth | 7½ out |
| » Defeated Twins (32-31), 9-5 | Memorial Stadium (16-14) | 30-32 | |
| » W: Wally Bunker (2-3) L: Mudcat Grant (4-6) S: Bill Dillman (2) | Fifth | 7½ out |
| Wednesday, June 21 |
| » Defeated Athletics (31-36), 5-4 | Memorial Stadium (17-14) | 31-32 | Won 2 |
| » W: Pete Richert (4-8) L: Jack Sanford (3-3) S: Eddie Watt (5) | Fifth | 7½ out |
| Friday, June 23 |
| » Lost to Senators (30-38), 3-2 | Robert F. Kennedy Stadium (2-2) | 31-33 | |
| » W: Phil Ortega (5-5) L: Steve Barber (4-7) S: Darold Knowles (5) | Seventh | 7½ out |
| » Major-league debuts: Jim Hardin (Orioles) |
| Saturday, June 24 |
| » Lost to Senators (31-38), 8-3 | Memorial Stadium (17-15) | 31-34 | Lost 2 |
| » W: Camilo Pascual (7-4) L: Bill Dillman (4-2) | Seventh | 8½ out |
| Sunday, June 25 |
| » Defeated Senators (31-39), 8-3 | Robert F. Kennedy Stadium (3-2) | 32-34 | |
| » W: Tom Phoebus (6-3) L: Bob Priddy (1-4) S: Moe Drabowsky (5) | Seventh | 7½ out |
| Monday, June 26 |
| » Lost to White Sox (40-26), 5-4 | Memorial Stadium (17-16) | 32-35 | |
| » W: Bob Locker (2-2) L: Stu Miller (1-6) S: Hoyt Wilhelm (5) | Sixth | 8½ out |
| Tuesday, June 27 |
| » Lost to White Sox (41-26), 5-0 | Memorial Stadium (17-17) | 32-36 | Lost 2 |
| » W: Joe Horlen (9-1) L: Steve Barber (4-8) | Seventh | 9½ out |
| Wednesday, June 28 |
| » Lost to White Sox (42-26), 3-2 | Memorial Stadium (17-18) | 32-37 | Lost 3 |
| » W: Bob Locker (3-2) L: Bill Dillman (4-3) S: Hoyt Wilhelm (6) | Seventh | 10½ out |
| Thursday, June 29 |
| » Defeated White Sox (42-27), 4-1 | Memorial Stadium (18-18) | 33-37 | |
| » W: Tom Phoebus (7-3) L: Jim O'Toole (4-2) | Sixth | 9½ out |
| Friday, June 30 |
| » Lost to Indians (37-35), 6-5 | Memorial Stadium (18-19) | 33-38 | |
| » W: George Culver (5-0) L: Wally Bunker (2-4) S: Orlando Pena (3) | Seventh | 9 out |
| » Defeated Indians (37-36), 8-1 | Memorial Stadium (19-19) | 34-38 | |
| » W: Dave McNally (4-5) L: Orlando Pena (0-3) S: Eddie Watt (6) | Seventh | 9 out |
| Saturday, July 1 |
| » Lost to Indians (38-36), 6-0 | Memorial Stadium (19-20) | 34-39 | |
| » W: John O'Donoghue (4-1) L: Steve Barber (4-9) | Seventh | 10 out |
| » Major-league debuts: Mike Adamson (Orioles) |
| Sunday, July 2 |
| » Defeated Indians (38-37), 1-0 | Memorial Stadium (20-20) | 35-39 | |
| » W: Bill Dillman (5-3) L: Sam McDowell (4-7) | Fifth | 9 out |
| Monday, July 3 |
| » Defeated White Sox (43-30), 1-0 | Comiskey Park I (1-1) | 36-39 | Won 2 |
| » W: Moe Drabowsky (6-0) L: John Buzhardt (2-7) | Fifth | 8 out |
| Tuesday, July 4 |
| » Lost to White Sox (44-30), 4-0 | Comiskey Park I (1-2) | 36-40 | |
| » W: Tommy John (7-5) L: Pete Richert (4-9) | Seventh | 9 out |
| Wednesday, July 5 |
| » Lost to White Sox (45-30), 3-2 | Comiskey Park I (1-3) | 36-41 | Lost 2 |
| » W: Bob Locker (4-2) L: Stu Miller (1-7) | Seventh | 10 out |
| » Major-league debuts: Curt Motton (Orioles) |
| Future Oriole Tim Worrell is born in Pasadena, CA. |
| Thursday, July 6 |
| » Defeated White Sox (45-31), 3-1 | Comiskey Park I (2-3) | 37-41 | |
| » W: Dave McNally (5-5) L: Jim O'Toole (4-3) | Seventh | 9 out |
| Friday, July 7 |
| » Lost to Yankees (35-43), 3-0 | Memorial Stadium (20-21) | 37-42 | |
| » W: Al Downing (9-5) L: Eddie Fisher (2-2) | Seventh | 10 out |
| Saturday, July 8 |
| » Defeated Yankees (35-44), 12-5 | Memorial Stadium (21-21) | 38-42 | |
| » W: Eddie Watt (1-4) L: Steve Barber (4-10) S: Moe Drabowsky (6) | Seventh | 10½ out |
| » Lost to Yankees (36-44), 3-1 | Memorial Stadium (21-22) | 38-43 | |
| » W: Fritz Peterson (1-8) L: Stu Miller (1-8) S: Dooley Womack (8) | Seventh | 10½ out |
| Sunday, July 9 |
| » Defeated Yankees (36-45), 2-1 | Memorial Stadium (22-22) | 39-43 | |
| » W: Pete Richert (5-9) L: Mel Stottlemyre (7-9) S: Eddie Fisher (1) | Seventh | 9 out |
| Thursday, July 13 |
| » Lost to Red Sox (42-39), 4-2 | Fenway Park (2-1) | 39-44 | |
| » W: Lee Stange (4-6) L: Tom Phoebus (7-4) S: John Wyatt (12) | Seventh | 9 out |
| » Defeated Red Sox (42-40), 10-0 | Fenway Park (3-1) | 40-44 | |
| » W: Dave McNally (6-5) L: Gary Bell (6-9) | Seventh | 9 out |
| Future Oriole Pat Rapp is born in Jennings, LA. |
| Friday, July 14 |
| » Lost to Red Sox (43-40), 11-5 | Fenway Park (3-2) | 40-45 | |
| » W: Jim Lonborg (12-3) L: Mike Adamson (0-1) | Seventh | 9½ out |
| Saturday, July 15 |
| » Lost to Red Sox (44-40), 5-1 | Fenway Park (3-3) | 40-46 | Lost 2 |
| » W: Jose Santiago (5-4) L: Pete Richert (5-10) S: Gary Bell (1) | Seventh | 9½ out |
| Sunday, July 16 |
| » Defeated Yankees (39-47), 2-1 | Yankee Stadium (3-1) | 41-46 | |
| » W: Pete Richert (6-10) L: Dooley Womack (4-4) | Sixth | 9 out |
| Monday, July 17 |
| » Defeated Yankees (39-48), 6-1 | Yankee Stadium (4-1) | 42-46 | Won 2 |
| » W: Tom Phoebus (8-4) L: Mel Stottlemyre (7-10) | Sixth | 8½ out |
| Tuesday, July 18 |
| » Lost to Red Sox (47-40), 6-2 | Memorial Stadium (22-23) | 42-47 | |
| » W: Jim Lonborg (13-3) L: Dave McNally (6-6) | Sixth | 8½ out |
| Wednesday, July 19 |
| » Lost to Red Sox (48-40), 6-4 | Memorial Stadium (22-24) | 42-48 | Lost 2 |
| » W: Jose Santiago (6-4) L: Pete Richert (6-11) | Eighth | 8½ out |
| Friday, July 21 |
| » Lost to Senators (44-49), 4-3 | Memorial Stadium (22-25) | 42-49 | Lost 3 |
| » W: Bob Humphreys (4-1) L: Tom Phoebus (8-5) S: Darold Knowles (9) | Eighth | 10 out |
| » Lost to Senators (45-49), 3-1 | Memorial Stadium (22-26) | 42-50 | Lost 4 |
| » W: Joe Coleman (7-6) L: Dave McNally (6-7) S: Darold Knowles (10) | Eighth | 10 out |
| Saturday, July 22 |
| » Lost to Senators (46-49), 7-5 | Memorial Stadium (22-27) | 42-51 | Lost 5 |
| » W: Camilo Pascual (9-7) L: Gene Brabender (0-1) S: Dick Lines (2) | Seventh | 10 out |
| Sunday, July 23 |
| » Defeated Senators (46-50), 7-3 | Robert F. Kennedy Stadium (4-2) | 43-51 | |
| » W: Eddie Fisher (3-2) L: Dave Baldwin (0-2) | Eighth | 10½ out |
| Thursday, July 27 |
| » Lost to Tigers (51-43), 4-0 | Memorial Stadium (22-28) | 43-52 | |
| » W: Denny McLain (12-11) L: Tom Phoebus (8-6) | Eighth | 12 out |
| Friday, July 28 |
| » Lost to Indians (45-53), 1-0 | Cleveland Stadium (1-2) | 43-53 | Lost 2 |
| » W: Steve Hargan (10-8) L: Moe Drabowsky (6-1) | Eighth | 12 out |
| » Major-league debuts: Dave May (Orioles) |
| Saturday, July 29 |
| » Defeated Indians (45-54), 5-3 | Cleveland Stadium (2-2) | 44-53 | |
| » W: Jim Hardin (1-0) L: John O'Donoghue (5-4) S: Eddie Watt (7) | Eighth | 12 out |
| Sunday, July 30 |
| » Lost to Indians (46-54), 8-3 | Cleveland Stadium (2-3) | 44-54 | |
| » W: Sam McDowell (8-9) L: Bill Dillman (5-4) | Seventh | 12 out |
| » Defeated Indians (46-55), 4-2 | Cleveland Stadium (3-3) | 45-54 | |
| » W: Stu Miller (2-8) L: Stan Williams (0-1) S: Moe Drabowsky (7) | Seventh | 12 out |
| Tuesday, August 1 |
| » Lost to Tigers (54-45), 4-2 | Memorial Stadium (22-29) | 45-55 | |
| » W: Earl Wilson (14-8) L: Tom Phoebus (8-7) S: John Hiller (1) | Seventh | 13½ out |
| Wednesday, August 2 |
| » Lost to Tigers (55-45), 4-2 | Memorial Stadium (22-30) | 45-56 | Lost 2 |
| » W: Joe Sparma (11-4) L: Gene Brabender (0-2) S: John Hiller (2) | Eighth | 13 out |
| » Defeated Tigers (55-46), 2-1 | Memorial Stadium (23-30) | 46-56 | |
| » W: Moe Drabowsky (7-1) L: Pat Dobson (0-1) | Eighth | 13 out |
| Thursday, August 3 |
| » Lost to Tigers (56-46), 5-0 | Memorial Stadium (23-31) | 46-57 | |
| » W: Denny McLain (13-12) L: Bill Dillman (5-5) | Eighth | 13½ out |
| Sunday, August 6 |
| » Defeated White Sox (59-44), 5-2 | Memorial Stadium (24-31) | 47-57 | |
| » W: Wally Bunker (3-4) L: Bruce Howard (3-9) S: Moe Drabowsky (8) | Eighth | 11½ out |
| » Defeated White Sox (59-45), 4-0 | Memorial Stadium (25-31) | 48-57 | Won 2 |
| » W: Tom Phoebus (9-7) L: Wilbur Wood (3-2) | Eighth | 11½ out |
| Monday, August 7 |
| » Defeated Indians (50-59), 4-0 | Memorial Stadium (26-31) | 49-57 | Won 3 |
| » W: Gene Brabender (1-2) L: John O'Donoghue (5-5) | Sixth | 11 out |
| Tuesday, August 8 |
| » Lost to Indians (51-59), 5-3 | Memorial Stadium (26-32) | 49-58 | |
| » W: Ed Connolly (1-1) L: Stu Miller (2-9) S: Sonny Siebert (3) | Eighth | 11½ out |
| Wednesday, August 9 |
| » Lost to Indians (52-59), 4-3 | Memorial Stadium (26-33) | 49-59 | Lost 2 |
| » W: Sam McDowell (10-9) L: Bill Dillman (5-6) S: Sonny Siebert (4) | Eighth | 11½ out |
| Thursday, August 10 |
| » Lost to Indians (53-59), 2-1 | Cleveland Stadium (3-4) | 49-60 | Lost 3 |
| » W: Stan Williams (2-1) L: Moe Drabowsky (7-2) | Eighth | 12½ out |
| Friday, August 11 |
| » Defeated Tigers (59-52), 5-1 | Tiger Stadium (1-3) | 50-60 | |
| » W: Tom Phoebus (10-7) L: Dave Wickersham (4-4) S: Stu Miller (5) | Eighth | 12 out |
| » Lost to Tigers (60-52), 5-2 | Tiger Stadium (1-4) | 50-61 | |
| » W: Mickey Lolich (6-12) L: Pete Richert (6-12) | Eighth | 12 out |
| Saturday, August 12 |
| » Lost to Tigers (61-52), 5-4 | Tiger Stadium (1-5) | 50-62 | Lost 2 |
| » W: Denny McLain (15-12) L: Gene Brabender (1-3) S: John Hiller (3) | Eighth | 12 out |
| Sunday, August 13 |
| » Lost to Tigers (62-52), 3-2 | Tiger Stadium (1-6) | 50-63 | Lost 3 |
| » W: Earl Wilson (16-9) L: Jim Hardin (1-1) S: Fred Lasher (1) | Ninth | 12½ out |
| Monday, August 14 |
| » Lost to Yankees (51-62), 5-4 | Yankee Stadium (4-2) | 50-64 | Lost 4 |
| » W: Steve Barber (8-13) L: Bill Dillman (5-7) S: Bill Monbouquette (1) | Ninth | 13½ out |
| Tuesday, August 15 |
| » Defeated Yankees (51-63), 11-10 | Yankee Stadium (5-2) | 51-64 | |
| » W: Pete Richert (7-12) L: Fritz Peterson (3-12) | Ninth | 13½ out |
| Wednesday, August 16 |
| » Defeated Yankees (51-64), 5-4 | Yankee Stadium (6-2) | 52-64 | Won 2 |
| » W: Tom Phoebus (11-7) L: Al Downing (12-6) S: Stu Miller (6) | Eighth | 13½ out |
| Future Oriole Bret Barberie is born in Long Beach, CA. |
| Thursday, August 17 |
| » Defeated Yankees (51-65), 4-1 | Yankee Stadium (7-2) | 53-64 | Won 3 |
| » W: Gene Brabender (2-3) L: Fritz Peterson (3-13) | Eighth | 13 out |
| Friday, August 18 |
| » Lost to White Sox (64-51), 3-1 | Comiskey Park I (2-4) | 53-65 | |
| » W: Joe Horlen (14-3) L: Moe Drabowsky (7-3) S: Hoyt Wilhelm (10) | Eighth | 13 out |
| » Defeated White Sox (64-52), 8-2 | Comiskey Park I (3-4) | 54-65 | |
| » W: Jim Hardin (2-1) L: Bruce Howard (3-10) | Eighth | 13 out |
| Sunday, August 20 |
| » Lost to White Sox (65-52), 4-2 | Comiskey Park I (3-5) | 54-66 | |
| » W: Gary Peters (14-6) L: Tom Phoebus (11-8) S: Bob Locker (13) | Eighth | 14 out |
| » Lost to White Sox (66-52), 2-1 | Comiskey Park I (3-6) | 54-67 | Lost 2 |
| » W: Don McMahon (3-2) L: Wally Bunker (3-5) | Eighth | 14 out |
| Monday, August 21 |
| » Defeated Athletics (52-70), 5-2 | Memorial Stadium (27-33) | 55-67 | |
| » W: Gene Brabender (3-3) L: Chuck Dobson (8-7) | Seventh | 13½ out |
| Tuesday, August 22 |
| » Defeated Athletics (52-71), 2-1 | Memorial Stadium (28-33) | 56-67 | Won 2 |
| » W: Jim Hardin (3-1) L: Blue Moon Odom (3-6) S: Moe Drabowsky (9) | Eighth | 13½ out |
| » Lost to Athletics (53-71), 6-1 | Memorial Stadium (28-34) | 56-68 | |
| » W: Catfish Hunter (11-12) L: Bill Dillman (5-8) | Eighth | 13½ out |
| Wednesday, August 23 |
| » Defeated Athletics (53-72), 1-0 | Memorial Stadium (29-34) | 57-68 | |
| » W: Pete Richert (8-12) L: Jim Nash (11-13) | Eighth | 13½ out |
| Saturday, August 26 |
| » Lost to Angels (65-62), 5-4 | Memorial Stadium (29-35) | 57-69 | |
| » W: Jim McGlothlin (11-5) L: Moe Drabowsky (7-4) S: Minnie Rojas (21) | Eighth | 14 out |
| Monday, August 28 |
| » Lost to Twins (73-56), 3-2 | Metropolitan Stadium (2-4) | 57-70 | Lost 2 |
| » W: Jim Perry (7-6) L: Pete Richert (8-13) S: Al Worthington (15) | Eighth | 15 out |
| Tuesday, August 29 |
| » Defeated Twins (73-57), 4-3 | Metropolitan Stadium (3-4) | 58-70 | |
| » W: Jim Hardin (4-1) L: Dave Boswell (11-9) S: Moe Drabowsky (10) | Eighth | 14½ out |
| Wednesday, August 30 |
| » Defeated Twins (73-58), 4-2 | Metropolitan Stadium (4-4) | 59-70 | Won 2 |
| » W: Eddie Watt (2-4) L: Dean Chance (17-10) | Eighth | 14½ out |
| Thursday, August 31 |
| » Lost to Twins (74-58), 10-9 | Metropolitan Stadium (4-5) | 59-71 | |
| » W: Ron Kline (7-0) L: Moe Drabowsky (7-5) | Eighth | 14½ out |
| Friday, September 1 |
| » Defeated Athletics (55-77), 2-1 | Municipal Stadium (3-4) | 60-71 | |
| » W: Pete Richert (9-13) L: Catfish Hunter (11-14) | Eighth | 14½ out |
| Saturday, September 2 |
| » Lost to Athletics (56-77), 8-6 | Municipal Stadium (3-5) | 60-72 | |
| » W: Diego Segui (3-4) L: Wally Bunker (3-6) S: Lew Krausse (4) | Eighth | 15 out |
| Sunday, September 3 |
| » Defeated Athletics (56-78), 6-0 | Municipal Stadium (4-5) | 61-72 | |
| » W: Jim Hardin (5-1) L: Blue Moon Odom (3-7) | Eighth | 14 out |
| Monday, September 4 |
| » Defeated Angels (69-66), 4-2 | Anaheim Stadium (4-4) | 62-72 | Won 2 |
| » W: Gene Brabender (4-3) L: Jack Hamilton (9-5) S: Stu Miller (7) | Eighth | 14 out |
| » Lost to Angels (70-66), 5-4 | Anaheim Stadium (4-5) | 62-73 | |
| » W: Jim Weaver (1-0) L: Eddie Fisher (3-3) | Eighth | 14 out |
| Tuesday, September 5 |
| » Lost to Angels (71-66), 7-2 | Anaheim Stadium (4-6) | 62-74 | Lost 2 |
| » W: Clyde Wright (4-3) L: Pete Richert (9-14) | Eighth | 15½ out |
| » Lost to Angels (72-66), 11-4 | Anaheim Stadium (4-7) | 62-75 | Lost 3 |
| » W: Bobby Locke (2-0) L: John Buzhardt (3-10) S: Bill Kelso (9) | Eighth | 15½ out |
| Wednesday, September 6 |
| » Major-league debuts: Hal King (Astros) |
| Thursday, September 7 |
| » Lost to Twins (79-61), 4-2 | Memorial Stadium (29-36) | 62-76 | Lost 4 |
| » W: Dean Chance (18-11) L: Jim Hardin (5-2) | Eighth | 16 out |
| Friday, September 8 |
| » Lost to Twins (80-61), 7-2 | Memorial Stadium (29-37) | 62-77 | Lost 5 |
| » W: Jim Merritt (12-4) L: Gene Brabender (4-4) | Seventh | 16 out |
| » Defeated Twins (80-62), 5-3 | Memorial Stadium (30-37) | 63-77 | |
| » W: Tom Phoebus (12-8) L: Jim Perry (7-7) S: Pete Richert (1) | Seventh | 16 out |
| Saturday, September 9 |
| » Lost to Twins (81-62), 3-2 | Memorial Stadium (30-38) | 63-78 | |
| » W: Jim Kaat (12-13) L: Bill Dillman (5-9) | Seventh | 17 out |
| Sunday, September 10 |
| » Lost to Twins (82-62), 4-2 | Memorial Stadium (30-39) | 63-79 | Lost 2 |
| » W: Dave Boswell (13-10) L: Wally Bunker (3-7) | Eighth | 18 out |
| Monday, September 11 |
| » Defeated White Sox (80-64), 6-1 | Comiskey Park I (4-6) | 64-79 | |
| » W: Jim Hardin (6-2) L: Fred Klages (4-4) | Eighth | 18 out |
| Tuesday, September 12 |
| » Lost to Tigers (82-64), 6-4 | Tiger Stadium (1-7) | 64-80 | |
| » W: Fred Gladding (6-4) L: Eddie Watt (2-5) S: Fred Lasher (7) | Seventh | 18 out |
| Wednesday, September 13 |
| » Lost to Tigers (83-64), 6-1 | Tiger Stadium (1-8) | 64-81 | Lost 2 |
| » W: Mickey Lolich (11-12) L: Pete Richert (9-15) | Eighth | 19 out |
| Thursday, September 14 |
| » Major-league debuts: Cito Gaston (Braves) |
| Friday, September 15 |
| » Defeated Red Sox (84-64), 6-2 | Fenway Park (4-3) | 65-81 | |
| » W: Tom Phoebus (13-8) L: Dave Morehead (5-4) S: Moe Drabowsky (11) | Seventh | 18 out |
| Saturday, September 16 |
| » Defeated Red Sox (84-65), 4-1 | Fenway Park (5-3) | 66-81 | Won 2 |
| » W: Jim Hardin (7-2) L: Jim Lonborg (20-8) | Seventh | 18 out |
| Sunday, September 17 |
| » Defeated Red Sox (84-66), 5-2 | Fenway Park (6-3) | 67-81 | Won 3 |
| » W: Gene Brabender (5-4) L: Gary Bell (12-12) S: Stu Miller (8) | Seventh | 17 out |
| Monday, September 18 |
| » Defeated Yankees (66-85), 2-0 | Memorial Stadium (31-39) | 68-81 | Won 4 |
| » W: Dave McNally (7-7) L: Bill Monbouquette (5-5) S: Bill Dillman (3) | Sixth | 16 out |
| Tuesday, September 19 |
| » Defeated Yankees (66-86), 3-0 | Memorial Stadium (32-39) | 69-81 | Won 5 |
| » W: Jim Palmer (3-1) L: Steve Barber (10-17) S: Pete Richert (2) | Seventh | 16 out |
| Wednesday, September 20 |
| » Defeated Senators (70-81), 4-3 | Robert F. Kennedy Stadium (5-2) | 70-81 | Won 6 |
| » W: Tom Phoebus (14-8) L: Dick Bosman (2-1) S: Moe Drabowsky (12) | Sixth | 15½ out |
| » Defeated Senators (70-82), 6-3 | Robert F. Kennedy Stadium (6-2) | 71-81 | Won 7 |
| » W: Eddie Fisher (4-3) L: Darold Knowles (6-8) | Sixth | 15½ out |
| » Major-league debuts: Tom Fisher (Orioles) |
| Thursday, September 21 |