| Thursday, January 5 |
| Future Indian Chris Nabholz is born in Harrisburg, PA. |
| Sunday, January 15 |
| Future Indian Bill Wertz is born in Cleveland, OH. |
| Thursday, January 26 |
| Future Indian Jeff Branson is born in Waynesboro, MS. |
| Saturday, February 18 |
| Future Indian Matt Turner is born in Lexington, KY. |
| Saturday, March 25 |
| Future Indian Brian Barnes is born in Roanoke Rapids, NC. |
| Monday, March 27 |
| Future Indian Jaime Navarro is born in Bayamon, P.R. |
| Wednesday, March 29 |
| Future Indian Geronimo Pena is born in Distrito Nacional, D.R. |
| Thursday, March 30 |
| Former Indian Ivan Howard dies in Medford, OR at the age of 85. |
| Tuesday, April 11 |
| » Lost to Athletics (1-0), 4-3 | Municipal Stadium (0-1) | 0-1 | |
| » W: Jim Nash (1-0) L: Steve Hargan (0-1) S: Jack Aker (1) | Third | 1 out |
| Friday, April 14 |
| » Lost to Angels (2-1), 10-1 | Anaheim Stadium (0-1) | 0-2 | Lost 2 |
| » W: Jack Sanford (1-0) L: Luis Tiant (0-1) S: Minnie Rojas (1) | Fifth | 2½ out |
| Saturday, April 15 |
| » Defeated Angels (2-2), 4-1 | Anaheim Stadium (1-1) | 1-2 | |
| » W: George Culver (1-0) L: Pete Cimino (0-1) | Fourth | 1½ out |
| Sunday, April 16 |
| » Defeated Twins (1-4), 4-3 | Metropolitan Stadium (1-0) | 2-2 | Won 2 |
| » W: Sam McDowell (1-0) L: Mudcat Grant (0-1) S: Bob Allen (1) | Third | 1 out |
| Monday, April 17 |
| Future Indian Marquis Grissom is born in Atlanta, GA. |
| Wednesday, April 19 |
| » Defeated Athletics (3-3), 4-1 | Cleveland Stadium (1-0) | 3-2 | Won 3 |
| » W: Sonny Siebert (1-0) L: Jim Nash (1-1) S: Bob Allen (2) | Second | ½ out |
| Thursday, April 20 |
| » Defeated Athletics (3-4), 2-0 | Cleveland Stadium (2-0) | 4-2 | Won 4 |
| » W: Steve Hargan (1-1) L: Lew Krausse (0-2) | First | -- |
| Friday, April 21 |
| » Lost to Angels (4-5), 6-5 | Cleveland Stadium (2-1) | 4-3 | |
| » W: Bill Kelso (1-0) L: Bob Allen (0-1) S: Lew Burdette (1) | Second | 1 out |
| Saturday, April 22 |
| » Lost to Angels (5-5), 11-4 | Cleveland Stadium (2-2) | 4-4 | Lost 2 |
| » W: Rickey Clark (1-0) L: Gary Bell (0-1) S: Pete Cimino (1) | Third | 1 out |
| » Major-league debuts: Rickey Clark (Angels) |
| Sunday, April 23 |
| » Lost to Angels (6-5), 9-6 | Cleveland Stadium (2-3) | 4-5 | Lost 3 |
| » W: Pete Cimino (1-1) L: Jack Kralick (0-1) | Sixth | 2 out |
| » Lost to Angels (7-5), 2-1 | Cleveland Stadium (2-4) | 4-6 | Lost 4 |
| » W: Minnie Rojas (1-0) L: Jack Kralick (0-2) S: Jack Sanford (1) | Sixth | 2 out |
| Monday, April 24 |
| Future Indian Omar Vizquel is born in Caracas, Venezuela. |
| Tuesday, April 25 |
| » Defeated Twins (4-6), 1-0 | Cleveland Stadium (3-4) | 5-6 | |
| » W: Steve Hargan (2-1) L: Mudcat Grant (0-2) | Sixth | 1½ out |
| Thursday, April 27 |
| » Defeated Twins (4-7), 5-4 | Cleveland Stadium (4-4) | 6-6 | Won 2 |
| » W: Sam McDowell (2-0) L: Al Worthington (1-1) S: George Culver (1) | Fourth | 1 out |
| Friday, April 28 |
| » Lost to White Sox (8-6), 3-2 | Comiskey Park I (0-1) | 6-7 | |
| » W: Bob Locker (1-0) L: Sonny Siebert (1-1) | Sixth | 2 out |
| Sunday, April 30 |
| » Defeated White Sox (8-7), 2-1 | Comiskey Park I (1-1) | 7-7 | |
| » W: Gary Bell (1-1) L: Bruce Howard (1-2) | Seventh | 2½ out |
| » Lost to White Sox (9-7), 4-2 | Comiskey Park I (1-2) | 7-8 | |
| » W: Hoyt Wilhelm (1-0) L: Steve Hargan (2-2) | Seventh | 2½ out |
| Monday, May 1 |
| » Lost to Orioles (9-8), 8-7 | Cleveland Stadium (4-5) | 7-9 | Lost 2 |
| » W: Eddie Fisher (1-1) L: Bob Allen (0-2) | Seventh | 3 out |
| Wednesday, May 3 |
| » Defeated Orioles (9-9), 5-1 | Cleveland Stadium (5-5) | 8-9 | |
| » W: Sonny Siebert (2-1) L: Dave McNally (1-1) | Fifth | 2 out |
| Friday, May 5 |
| » Lost to White Sox (11-7), 3-2 | Cleveland Stadium (5-6) | 8-10 | |
| » W: Tommy John (1-2) L: Steve Hargan (2-3) | Seventh | 3 out |
| Future Indian Charles Nagy is born in Bridgeport, CT. |
| Saturday, May 6 |
| » Lost to White Sox (12-7), 2-0 | Cleveland Stadium (5-7) | 8-11 | Lost 2 |
| » W: Joe Horlen (3-0) L: Gary Bell (1-2) S: Bob Locker (3) | Seventh | 4 out |
| Tuesday, May 9 |
| » Lost to Tigers (14-7), 4-3 | Cleveland Stadium (5-8) | 8-12 | Lost 3 |
| » W: Denny McLain (3-3) L: Sam McDowell (2-1) S: Fred Gladding (3) | Ninth | 5½ out |
| Wednesday, May 10 |
| » Lost to Tigers (15-7), 4-2 | Cleveland Stadium (5-9) | 8-13 | Lost 4 |
| » W: Mickey Lolich (4-1) L: Sonny Siebert (2-2) S: Fred Gladding (4) | Tenth | 6½ out |
| Thursday, May 11 |
| » Defeated Senators (12-12), 2-1 | Robert F. Kennedy Stadium (1-0) | 9-13 | |
| » W: Steve Hargan (3-3) L: Camilo Pascual (2-1) | Eighth | 6 out |
| Friday, May 12 |
| » Defeated Senators (12-13), 12-5 | Robert F. Kennedy Stadium (2-0) | 10-13 | Won 2 |
| » W: George Culver (2-0) L: Bob Priddy (0-1) | Eighth | 6 out |
| Saturday, May 13 |
| » Defeated Senators (12-14), 3-1 | Robert F. Kennedy Stadium (3-0) | 11-13 | Won 3 |
| » W: Luis Tiant (1-1) L: Pete Richert (1-5) S: Orlando Pena (1) | Fifth | 6 out |
| Sunday, May 14 |
| » Defeated Senators (12-15), 2-1 | Robert F. Kennedy Stadium (4-0) | 12-13 | Won 4 |
| » W: Sonny Siebert (3-2) L: Phil Ortega (1-3) | Fourth | 6 out |
| Tuesday, May 16 |
| » Lost to Yankees (13-13), 4-3 | Yankee Stadium (0-1) | 12-14 | |
| » W: Thad Tillotson (1-0) L: Bob Allen (0-3) | Sixth | 6 out |
| Wednesday, May 17 |
| » Defeated Yankees (13-14), 8-7 | Yankee Stadium (1-1) | 13-14 | |
| » W: Steve Hargan (4-3) L: Fred Talbot (1-1) S: John O'Donoghue (1) | Fourth | 6 out |
| Friday, May 19 |
| » Lost to Red Sox (14-16), 3-2 | Fenway Park (0-1) | 13-15 | |
| » W: Jim Lonborg (4-1) L: Gary Bell (1-3) | Fifth | 7 out |
| Saturday, May 20 |
| » Defeated Red Sox (14-17), 5-3 | Fenway Park (1-1) | 14-15 | |
| » W: Steve Bailey (1-0) L: Don McMahon (1-2) | Fifth | 6 out |
| Sunday, May 21 |
| » Lost to Red Sox (15-17), 4-3 | Fenway Park (1-2) | 14-16 | |
| » W: John Wyatt (3-2) L: Sonny Siebert (3-3) S: Lee Stange (1) | Sixth | 6½ out |
| » Lost to Red Sox (16-17), 6-2 | Fenway Park (1-3) | 14-17 | Lost 2 |
| » W: Bucky Brandon (1-4) L: Sam McDowell (2-2) | Sixth | 6½ out |
| Monday, May 22 |
| » Defeated Senators (14-19), 5-0 | Cleveland Stadium (6-9) | 15-17 | |
| » W: Steve Hargan (5-3) L: Camilo Pascual (3-2) | Sixth | 6 out |
| Tuesday, May 23 |
| » Defeated Senators (14-20), 4-1 | Cleveland Stadium (7-9) | 16-17 | Won 2 |
| » W: Steve Bailey (2-0) L: Bob Priddy (0-2) | Sixth | 5½ out |
| Wednesday, May 24 |
| » Defeated Senators (14-21), 9-1 | Cleveland Stadium (8-9) | 17-17 | Won 3 |
| » W: Luis Tiant (2-1) L: Phil Ortega (1-5) | Fourth | 5½ out |
| Thursday, May 25 |
| » Lost to Senators (15-21), 2-1 | Cleveland Stadium (8-10) | 17-18 | |
| » W: Barry Moore (3-1) L: Steve Bailey (2-1) S: Dave Baldwin (3) | Fifth | 6 out |
| Friday, May 26 |
| » Defeated Yankees (15-20), 4-3 | Cleveland Stadium (9-10) | 18-18 | |
| » W: Steve Hargan (6-3) L: Fritz Peterson (0-3) | Fourth | 5½ out |
| Saturday, May 27 |
| » Defeated Yankees (15-21), 5-3 | Cleveland Stadium (10-10) | 19-18 | Won 2 |
| » W: Sonny Siebert (4-3) L: Steve Hamilton (1-1) S: John O'Donoghue (2) | Fourth | 5½ out |
| Sunday, May 28 |
| » Lost to Yankees (16-21), 5-0 | Cleveland Stadium (10-11) | 19-19 | |
| » W: Mel Stottlemyre (4-4) L: Gary Bell (1-4) | Fourth | 5½ out |
| Tuesday, May 30 |
| » Lost to Orioles (20-18), 5-4 | Memorial Stadium (0-1) | 19-20 | Lost 2 |
| » W: Dave McNally (3-2) L: Steve Hargan (6-4) S: Eddie Watt (3) | Fifth | 6 out |
| » Defeated Orioles (20-19), 3-2 | Memorial Stadium (1-1) | 20-20 | |
| » W: Sam McDowell (3-2) L: Wally Bunker (1-3) | Fifth | 6 out |
| Wednesday, May 31 |
| » Defeated Tigers (26-15), 9-0 | Tiger Stadium (1-0) | 21-20 | Won 2 |
| » W: Luis Tiant (3-1) L: Mickey Lolich (5-5) | Fourth | 5 out |
| » Major-league debuts: Pat Dobson and Mike Marshall (Tigers) |
| Future Indian Kenny Lofton is born in East Chicago, IN. |
| Thursday, June 1 |
| » Defeated Tigers (26-16), 8-2 | Tiger Stadium (2-0) | 22-20 | Won 3 |
| » W: John O'Donoghue (1-0) L: Denny McLain (5-6) | Third | 4 out |
| Friday, June 2 |
| » Lost to Red Sox (23-21), 2-1 | Cleveland Stadium (10-12) | 22-21 | |
| » W: Jim Lonborg (7-1) L: Sonny Siebert (4-4) | Fourth | 5 out |
| Saturday, June 3 |
| » Lost to Red Sox (24-21), 6-2 | Cleveland Stadium (10-13) | 22-22 | Lost 2 |
| » W: Dennis Bennett (4-1) L: Gary Bell (1-5) S: Jose Santiago (1) | Fifth | 5 out |
| Sunday, June 4 |
| » Defeated Red Sox (24-22), 3-0 | Cleveland Stadium (11-13) | 23-22 | |
| » W: Steve Hargan (7-4) L: Lee Stange (0-3) | Fifth | 4½ out |
| Monday, June 5 |
| » Lost to Twins (24-23), 5-4 | Metropolitan Stadium (1-1) | 23-23 | |
| » W: Al Worthington (2-2) L: Steve Bailey (2-2) | Sixth | 5½ out |
| Tuesday, June 6 |
| » Defeated Twins (24-24), 6-4 | Metropolitan Stadium (2-1) | 24-23 | |
| » W: Sonny Siebert (5-4) L: Jim Perry (1-4) S: Bob Allen (3) | Sixth | 6½ out |
| » Lost to Twins (25-24), 7-1 | Metropolitan Stadium (2-2) | 24-24 | |
| » W: Dave Boswell (3-3) L: John O'Donoghue (1-1) | Sixth | 6½ out |
| Thursday, June 8 |
| » Defeated Twins (25-25), 7-5 | Metropolitan Stadium (3-2) | 25-24 | |
| » W: George Culver (3-0) L: Al Worthington (2-3) | Fourth | 5½ out |
| Friday, June 9 |
| » Lost to Athletics (24-28), 2-0 | Municipal Stadium (0-2) | 25-25 | |
| » W: Chuck Dobson (3-2) L: Steve Hargan (7-5) | Sixth | 6 out |
| » Lost to Athletics (25-28), 6-0 | Municipal Stadium (0-3) | 25-26 | Lost 2 |
| » W: Catfish Hunter (5-4) L: Sam McDowell (3-3) | Sixth | 6 out |
| » Major-league debuts: Reggie Jackson (Athletics) |
| Saturday, June 10 |
| » Lost to Athletics (26-28), 10-1 | Municipal Stadium (0-4) | 25-27 | Lost 3 |
| » W: Jim Nash (7-5) L: Sonny Siebert (5-5) | Seventh | 6 out |
| Sunday, June 11 |
| » Defeated Athletics (26-29), 12-1 | Municipal Stadium (1-4) | 26-27 | |
| » W: Luis Tiant (4-1) L: Diego Segui (0-2) | Fifth | 5½ out |
| » Defeated Athletics (26-30), 3-2 | Municipal Stadium (2-4) | 27-27 | Won 2 |
| » W: John O'Donoghue (2-1) L: Paul Lindblad (4-1) S: Orlando Pena (2) | Fifth | 5½ out |
| Monday, June 12 |
| » Defeated Angels (25-33), 7-5 | Anaheim Stadium (2-1) | 28-27 | Won 3 |
| » W: George Culver (4-0) L: Minnie Rojas (4-5) | Fifth | 4½ out |
| Tuesday, June 13 |
| » Lost to Angels (26-33), 8-3 | Anaheim Stadium (2-2) | 28-28 | |
| » W: George Brunet (3-9) L: Steve Hargan (7-6) | Sixth | 6 out |
| » Lost to Angels (27-33), 5-3 | Anaheim Stadium (2-3) | 28-29 | Lost 2 |
| » W: Rickey Clark (3-6) L: Sam McDowell (3-4) S: Bill Kelso (2) | Sixth | 6 out |
| Wednesday, June 14 |
| » Lost to Angels (28-33), 3-2 | Anaheim Stadium (2-4) | 28-30 | Lost 3 |
| » W: Minnie Rojas (5-5) L: Sonny Siebert (5-6) | Fifth | 6½ out |
| Future Indian Jerry Spradlin is born in Fullerton, CA. |
| Friday, June 16 |
| » Defeated Twins (30-29), 2-1 | Cleveland Stadium (12-13) | 29-30 | |
| » W: Luis Tiant (5-1) L: Al Worthington (2-4) | Fifth | 5½ out |
| Saturday, June 17 |
| » Defeated Twins (30-30), 7-3 | Cleveland Stadium (13-13) | 30-30 | Won 2 |
| » W: John O'Donoghue (3-1) L: Dean Chance (9-5) S: Steve Bailey (1) | Fourth | 5½ out |
| Sunday, June 18 |
| » Lost to Twins (31-30), 4-2 | Cleveland Stadium (13-14) | 30-31 | |
| » W: Jim Kaat (4-7) L: Sam McDowell (3-5) S: Ron Kline (2) | Fifth | 7 out |
| Monday, June 19 |
| » Defeated Athletics (31-33), 4-2 | Cleveland Stadium (14-14) | 31-31 | |
| » W: Steve Hargan (8-6) L: Chuck Dobson (4-3) | Third | 6 out |
| » Defeated Athletics (31-34), 2-1 | Cleveland Stadium (15-14) | 32-31 | Won 2 |
| » W: Sonny Siebert (6-6) L: Lew Krausse (3-10) S: Bob Allen (4) | Third | 6 out |
| Tuesday, June 20 |
| » Defeated Athletics (31-35), 5-3 | Cleveland Stadium (16-14) | 33-31 | Won 3 |
| » W: Luis Tiant (6-1) L: Jim Nash (7-6) S: Steve Bailey (2) | Third | 5 out |
| Thursday, June 22 |
| » Lost to Angels (33-36), 7-0 | Cleveland Stadium (16-15) | 33-32 | |
| » W: Jim McGlothlin (7-1) L: Sam McDowell (3-6) | Fourth | 6½ out |
| Friday, June 23 |
| » Lost to Red Sox (34-31), 8-4 | Fenway Park (1-4) | 33-33 | Lost 2 |
| » W: Lee Stange (2-4) L: Sonny Siebert (6-7) | Fifth | 6½ out |
| Saturday, June 24 |
| » Defeated Red Sox (34-32), 3-2 | Fenway Park (2-4) | 34-33 | |
| » W: Steve Hargan (9-6) L: Bucky Brandon (2-7) | Fourth | 6½ out |
| Sunday, June 25 |
| » Lost to Red Sox (35-32), 8-3 | Fenway Park (2-5) | 34-34 | |
| » W: Gary Bell (5-6) L: Luis Tiant (6-2) S: Jose Santiago (2) | Fifth | 6½ out |
| Tuesday, June 27 |
| » Defeated Tigers (36-32), 8-1 | Tiger Stadium (3-0) | 35-34 | |
| » W: Sam McDowell (4-6) L: Earl Wilson (8-7) | Fourth | 7 out |
| Wednesday, June 28 |
| » Lost to Tigers (37-32), 7-4 | Tiger Stadium (3-1) | 35-35 | |
| » W: Joe Sparma (8-1) L: Orlando Pena (0-2) S: Dave Wickersham (3) | Fourth | 8 out |
| Thursday, June 29 |
| » Defeated Tigers (37-33), 5-3 | Tiger Stadium (4-1) | 36-35 | |
| » W: Luis Tiant (7-2) L: Denny McLain (8-9) S: George Culver (2) | Fourth | 7 out |
| Friday, June 30 |
| » Defeated Orioles (33-38), 6-5 | Memorial Stadium (2-1) | 37-35 | Won 2 |
| » W: George Culver (5-0) L: Wally Bunker (2-4) S: Orlando Pena (3) | Fifth | 6½ out |
| » Lost to Orioles (34-38), 8-1 | Memorial Stadium (2-2) | 37-36 | |
| » W: Dave McNally (4-5) L: Orlando Pena (0-3) S: Eddie Watt (6) | Fifth | 6½ out |
| Saturday, July 1 |
| » Defeated Orioles (34-39), 6-0 | Memorial Stadium (3-2) | 38-36 | |
| » W: John O'Donoghue (4-1) L: Steve Barber (4-9) | Fourth | 6½ out |
| » Major-league debuts: Mike Adamson (Orioles) |
| Sunday, July 2 |
| » Lost to Orioles (35-39), 1-0 | Memorial Stadium (3-3) | 38-37 | |
| » W: Bill Dillman (5-3) L: Sam McDowell (4-7) | Third | 6½ out |
| Monday, July 3 |
| » Lost to Tigers (40-34), 2-1 | Cleveland Stadium (16-16) | 38-38 | Lost 2 |
| » W: Denny McLain (9-9) L: Luis Tiant (7-3) | Third | 6½ out |
| Tuesday, July 4 |
| » Lost to Tigers (41-34), 6-1 | Cleveland Stadium (16-17) | 38-39 | Lost 3 |
| » W: Earl Wilson (9-7) L: Steve Hargan (9-7) | Sixth | 7½ out |
| Wednesday, July 5 |
| » Lost to Tigers (42-34), 3-2 | Cleveland Stadium (16-18) | 38-40 | Lost 4 |
| » W: Fred Gladding (3-3) L: George Culver (5-1) S: Mike Marshall (2) | Sixth | 8½ out |
| Future Indian Tim Worrell is born in Pasadena, CA. |
| Friday, July 7 |
| » Defeated Senators (34-46), 6-3 | Cleveland Stadium (17-18) | 39-40 | |
| » W: Sam McDowell (5-7) L: Camilo Pascual (7-6) | Sixth | 8 out |
| Saturday, July 8 |
| » Defeated Senators (34-47), 4-3 | Cleveland Stadium (18-18) | 40-40 | Won 2 |
| » W: George Culver (6-1) L: Casey Cox (2-1) | Sixth | 8 out |
| Sunday, July 9 |
| » Lost to Senators (35-47), 8-5 | Cleveland Stadium (18-19) | 40-41 | |
| » W: Dick Lines (1-2) L: Steve Bailey (2-3) S: Bob Humphreys (2) | Sixth | 8 out |
| » Lost to Senators (36-47), 4-2 | Cleveland Stadium (18-20) | 40-42 | Lost 2 |
| » W: Barry Moore (5-7) L: Sonny Siebert (6-8) S: Dave Baldwin (6) | Sixth | 8 out |
| Wednesday, July 12 |
| » Defeated White Sox (47-34), 5-3 | Cleveland Stadium (19-20) | 41-42 | |
| » W: Sam McDowell (6-7) L: Tommy John (8-6) | Sixth | 7 out |
| Thursday, July 13 |
| » Defeated Yankees (36-46), 4-3 | Yankee Stadium (2-1) | 42-42 | Won 2 |
| » W: George Culver (7-1) L: Thad Tillotson (3-5) | Sixth | 7 out |
| Friday, July 14 |
| » Lost to Yankees (37-46), 2-1 | Yankee Stadium (2-2) | 42-43 | |
| » W: Al Downing (10-5) L: John O'Donoghue (4-2) | Sixth | 8 out |
| » Lost to Yankees (38-46), 2-0 | Yankee Stadium (2-3) | 42-44 | Lost 2 |
| » W: Fritz Peterson (2-8) L: Sonny Siebert (6-9) | Sixth | 8 out |
| Saturday, July 15 |
| » Lost to Yankees (39-46), 4-1 | Yankee Stadium (2-4) | 42-45 | Lost 3 |
| » W: Steve Barber (5-10) L: Ed Connolly (0-1) | Sixth | 8 out |
| Sunday, July 16 |
| » Lost to Senators (41-47), 4-1 | Robert F. Kennedy Stadium (4-1) | 42-46 | Lost 4 |
| » W: Bob Humphreys (3-1) L: Sam McDowell (6-8) S: Bob Priddy (2) | Fifth | 8½ out |
| Monday, July 17 |
| » Lost to Senators (42-47), 4-2 | Robert F. Kennedy Stadium (4-2) | 42-47 | Lost 5 |
| » W: Joe Coleman (6-6) L: Luis Tiant (7-4) S: Darold Knowles (8) | Seventh | 9 out |
| Wednesday, July 19 |
| » Defeated Yankees (39-49), 5-2 | Cleveland Stadium (20-20) | 43-47 | |
| » W: John O'Donoghue (5-2) L: Thad Tillotson (3-6) | Sixth | 7½ out |
| Thursday, July 20 |
| » Defeated Yankees (39-50), 4-0 | Cleveland Stadium (21-20) | 44-47 | Won 2 |
| » W: Sam McDowell (7-8) L: Fritz Peterson (2-9) | Sixth | 7 out |
| Friday, July 21 |
| » Lost to Red Sox (49-40), 6-2 | Cleveland Stadium (21-21) | 44-48 | |
| » W: Bucky Brandon (4-7) L: Luis Tiant (7-5) | Seventh | 8 out |
| Saturday, July 22 |
| » Lost to Red Sox (50-40), 4-0 | Cleveland Stadium (21-22) | 44-49 | Lost 2 |
| » W: Lee Stange (6-6) L: Steve Hargan (9-8) | Sixth | 8 out |
| Sunday, July 23 |
| » Lost to Red Sox (51-40), 8-5 | Cleveland Stadium (21-23) | 44-50 | Lost 3 |
| » W: Jim Lonborg (14-3) L: John O'Donoghue (5-3) | Seventh | 10 out |
| » Lost to Red Sox (52-40), 5-1 | Cleveland Stadium (21-24) | 44-51 | Lost 4 |
| » W: Gary Bell (7-9) L: Luis Tiant (7-6) | Seventh | 10 out |
| Tuesday, July 25 |
| » Lost to White Sox (54-40), 3-1 | Comiskey Park I (1-3) | 44-52 | Lost 5 |
| » W: Hoyt Wilhelm (5-1) L: Sam McDowell (7-9) | Eighth | 12 out |
| » Lost to White Sox (55-40), 6-5 | Comiskey Park I (1-4) | 44-53 | Lost 6 |
| » W: John Buzhardt (3-8) L: Steve Bailey (2-4) | Eighth | 12 out |
| Friday, July 28 |
| » Defeated Orioles (43-53), 1-0 | Cleveland Stadium (22-24) | 45-53 | |
| » W: Steve Hargan (10-8) L: Moe Drabowsky (6-1) | Seventh | 11 out |
| » Major-league debuts: Dave May (Orioles) |
| Saturday, July 29 |
| » Lost to Orioles (44-53), 5-3 | Cleveland Stadium (22-25) | 45-54 | |
| » W: Jim Hardin (1-0) L: John O'Donoghue (5-4) S: Eddie Watt (7) | Seventh | 12 out |
| Sunday, July 30 |
| » Defeated Orioles (44-54), 8-3 | Cleveland Stadium (23-25) | 46-54 | |
| » W: Sam McDowell (8-9) L: Bill Dillman (5-4) | Eighth | 12 out |
| » Lost to Orioles (45-54), 4-2 | Cleveland Stadium (23-26) | 46-55 | |
| » W: Stu Miller (2-8) L: Stan Williams (0-1) S: Moe Drabowsky (7) | Eighth | 12 out |
| Monday, July 31 |
| » Lost to White Sox (58-42), 4-2 | Cleveland Stadium (23-27) | 46-56 | Lost 2 |
| » W: Bob Locker (5-2) L: Luis Tiant (7-7) | Eighth | 13 out |
| Tuesday, August 1 |
| » Lost to White Sox (59-42), 11-5 | Cleveland Stadium (23-28) | 46-57 | Lost 3 |
| » W: Hoyt Wilhelm (6-1) L: Bob Allen (0-4) | Eighth | 14 out |
| Wednesday, August 2 |
| » Defeated White Sox (59-43), 5-1 | Cleveland Stadium (24-28) | 47-57 | |
| » W: Steve Hargan (11-8) L: Wilbur Wood (3-1) | Seventh | 13 out |
| Friday, August 4 |
| » Defeated Tigers (56-47), 11-5 | Cleveland Stadium (25-28) | 48-57 | Won 2 |
| » W: Sam McDowell (9-9) L: Johnny Podres (3-1) S: Sonny Siebert (1) | Seventh | 12½ out |
| Saturday, August 5 |
| » Defeated Tigers (56-48), 5-3 | Cleveland Stadium (26-28) | 49-57 | Won 3 |
| » W: Stan Williams (1-1) L: Earl Wilson (14-9) S: Sonny Siebert (2) | Sixth | 12 out |
| Sunday, August 6 |
| » Lost to Tigers (57-48), 7-3 | Cleveland Stadium (26-29) | 49-58 | |
| » W: Joe Sparma (12-4) L: George Culver (7-2) | Seventh | 11 out |
| » Defeated Tigers (57-49), 6-3 | Cleveland Stadium (27-29) | 50-58 | |
| » W: Steve Hargan (12-8) L: Pat Dobson (0-2) S: Orlando Pena (4) | Seventh | 11 out |
| Monday, August 7 |
| » Lost to Orioles (49-57), 4-0 | Memorial Stadium (3-4) | 50-59 | |
| » W: Gene Brabender (1-2) L: John O'Donoghue (5-5) | Seventh | 11½ out |
| Future Indian Jason Grimsley is born in Cleveland, TX. |
| Tuesday, August 8 |
| » Defeated Orioles (49-58), 5-3 | Memorial Stadium (4-4) | 51-59 | |
| » W: Ed Connolly (1-1) L: Stu Miller (2-9) S: Sonny Siebert (3) | Seventh | 11 out |
| Wednesday, August 9 |
| » Defeated Orioles (49-59), 4-3 | Memorial Stadium (5-4) | 52-59 | Won 2 |
| » W: Sam McDowell (10-9) L: Bill Dillman (5-6) S: Sonny Siebert (4) | Seventh | 10 out |
| Thursday, August 10 |
| » Defeated Orioles (49-60), 2-1 | Cleveland Stadium (28-29) | 53-59 | Won 3 |
| » W: Stan Williams (2-1) L: Moe Drabowsky (7-2) | Seventh | 10 out |
| Friday, August 11 |
| » Lost to Yankees (48-61), 5-3 | Cleveland Stadium (28-30) | 53-60 | |
| » W: Al Downing (12-5) L: Steve Hargan (12-9) | Seventh | 10½ out |
| » Lost to Yankees (49-61), 4-1 | Cleveland Stadium (28-31) | 53-61 | Lost 2 |
| » W: Mel Stottlemyre (11-10) L: Luis Tiant (7-8) | Seventh | 10½ out |
| Saturday, August 12 |
| » Defeated Yankees (49-62), 6-2 | Cleveland Stadium (29-31) | 54-61 | |
| » W: John O'Donoghue (6-5) L: Fritz Peterson (2-11) | Seventh | 9½ out |
| Sunday, August 13 |
| » Lost to Yankees (50-62), 15-11 | Cleveland Stadium (29-32) | 54-62 | |
| » W: Fritz Peterson (3-11) L: Sonny Siebert (6-10) | Seventh | 10 out |
| Monday, August 14 |
| » Major-league debuts: Moose Stubing (Angels) |
| Tuesday, August 15 |
| » Defeated Senators (58-59), 3-0 | Robert F. Kennedy Stadium (5-2) | 55-62 | |
| » W: Stan Williams (3-1) L: Darold Knowles (5-6) | Seventh | 10½ out |
| Wednesday, August 16 |
| » Defeated Senators (58-60), 1-0 | Robert F. Kennedy Stadium (6-2) | 56-62 | Won 2 |
| » W: Steve Hargan (13-9) L: Camilo Pascual (11-9) | Seventh | 10½ out |
| Thursday, August 17 |
| » Defeated Senators (58-61), 8-3 | Robert F. Kennedy Stadium (7-2) | 57-62 | Won 3 |
| » W: Ed Connolly (2-1) L: Dick Lines (1-3) | Seventh | 10 out |
| Former Indian Ray Caldwell dies in Salamanca, NY at the age of 80. |
| Friday, August 18 |
| » Lost to Tigers (64-54), 4-0 | Tiger Stadium (4-2) | 57-63 | |
| » W: Mickey Lolich (7-12) L: Sam McDowell (10-10) | Seventh | 10½ out |
| Saturday, August 19 |
| » Defeated Tigers (64-55), 5-0 | Tiger Stadium (5-2) | 58-63 | |
| » W: John O'Donoghue (7-5) L: Joe Sparma (12-6) | Seventh | 10½ out |
| Sunday, August 20 |
| » Lost to Tigers (65-55), 4-2 | Tiger Stadium (5-3) | 58-64 | |
| » W: Denny McLain (16-13) L: Stan Williams (3-2) S: Fred Lasher (2) | Seventh | 11 out |
| » Lost to Tigers (66-55), 4-0 | Tiger Stadium (5-4) | 58-65 | Lost 2 |
| » W: John Hiller (2-0) L: Sam McDowell (10-11) | Seventh | 11 out |
| Monday, August 21 |
| » Lost to Angels (63-60), 6-4 | Cleveland Stadium (29-33) | 58-66 | Lost 3 |
| » W: Jim Coates (1-2) L: Steve Hargan (13-10) | Sixth | 11½ out |
| Tuesday, August 22 |
| » Defeated Angels (63-61), 3-2 | Cleveland Stadium (30-33) | 59-66 | |
| » W: Luis Tiant (8-8) L: George Brunet (11-16) | Seventh | 11 out |
| Wednesday, August 23 |
| » Lost to Angels (64-61), 16-5 | Cleveland Stadium (30-34) | 59-67 | |
| » W: Jack Hamilton (9-3) L: John O'Donoghue (7-6) | Seventh | 12 out |
| Thursday, August 24 |
| » Defeated Angels (64-62), 2-1 | Cleveland Stadium (31-34) | 60-67 | |
| » W: Sam McDowell (11-11) L: Rickey Clark (9-9) | Seventh | 11 out |
| Friday, August 25 |
| » Lost to Twins (70-55), 6-5 | Cleveland Stadium (31-35) | 60-68 | |
| » W: Ron Kline (6-0) L: John O'Donoghue (7-7) | Seventh | 12½ out |
| » Lost to Twins (71-55), 2-1 | Cleveland Stadium (31-36) | 60-69 | Lost 2 |
| » W: Dean Chance (17-9) L: Sonny Siebert (6-11) | Seventh | 12½ out |
| Saturday, August 26 |
| » Defeated Twins (71-56), 5-2 | Cleveland Stadium (32-36) | 61-69 | |
| » W: Steve Hargan (14-10) L: Jim Kaat (9-13) | Seventh | 12 out |
| Sunday, August 27 |
| » Lost to Twins (72-56), 6-3 | Cleveland Stadium (32-37) | 61-70 | |
| » W: Jim Merritt (10-4) L: Luis Tiant (8-9) | Seventh | 12½ out |
| Monday, August 28 |
| » Defeated Athletics (54-75), 8-7 | Municipal Stadium (3-4) | 62-70 | |
| » W: Stan Williams (4-2) L: Jack Aker (3-7) S: Luis Tiant (1) | Seventh | 12½ out |
| Tuesday, August 29 |
| » Defeated Athletics (54-76), 9-8 | Municipal Stadium (4-4) | 63-70 | Won 2 |
| » W: Stan Williams (5-2) L: Diego Segui (2-4) S: Luis Tiant (2) | Seventh | 12 out |
| Wednesday, August 30 |
| » Lost to Athletics (55-76), 6-5 | Municipal Stadium (4-5) | 63-71 | |
| » W: Lew Krausse (7-14) L: Steve Hargan (14-11) | Seventh | 13 out |
| Friday, September 1 |
| » Lost to Angels (67-65), 4-3 | Anaheim Stadium (2-5) | 63-72 | Lost 2 |
| » W: Bobby Locke (1-0) L: Sam McDowell (11-12) | Seventh | 13½ out |
| » Major-league debuts: Aurelio Rodriguez (Angels) |
| Saturday, September 2 |
| » Lost to Angels (68-65), 1-0 | Anaheim Stadium (2-6) | 63-73 | Lost 3 |
| » W: Minnie Rojas (10-8) L: Bob Allen (0-5) | Seventh | 14 out |
| Sunday, September 3 |
| » Lost to Angels (69-65), 6-2 | Anaheim Stadium (2-7) | 63-74 | Lost 4 |
| » W: Rickey Clark (10-10) L: Stan Williams (5-3) S: Minnie Rojas (22) | Seventh | 14 out |
| Monday, September 4 |
| » Lost to Twins (77-59), 4-1 | Metropolitan Stadium (3-3) | 63-75 | Lost 5 |
| » W: Jim Merritt (11-4) L: Steve Hargan (14-12) | Seventh | 14 out |
| » Defeated Twins (77-60), 2-1 | Metropolitan Stadium (4-3) | 64-75 | |
| » W: Sonny Siebert (7-11) L: Al Worthington (8-9) S: George Culver (3) | Seventh | 14 out |
| Tuesday, September 5 |
| » Lost to Twins (78-60), 9-2 | Metropolitan Stadium (4-4) | 64-76 | |
| » W: Jim Kaat (11-13) L: Sam McDowell (11-13) | Seventh | 15 out |
| Wednesday, September 6 |
| » Defeated Twins (78-61), 3-2 | Metropolitan Stadium (5-4) | 65-76 | |
| » W: Luis Tiant (9-9) L: Dave Boswell (12-10) | Fifth | 14 out |
| » Major-league debuts: Pat Kelly and Graig Nettles (Twins) |
| Friday, September 8 |
| » Defeated Athletics (57-83), 6-3 | Cleveland Stadium (33-37) | 66-76 | Won 2 |
| » W: Sonny Siebert (8-11) L: Blue Moon Odom (3-8) | Sixth | 14 out |
| » Major-league debuts: Ray Fosse (Indians) |
| Saturday, September 9 |
| » Lost to Athletics (58-83), 6-1 | Cleveland Stadium (33-38) | 66-77 | |
| » W: Jim Nash (12-14) L: Stan Williams (5-4) | Sixth | 15 out |
| Sunday, September 10 |
| » Defeated Athletics (58-84), 1-0 | Cleveland Stadium (34-38) | 67-77 | |
| » W: John O'Donoghue (8-7) L: Tony Pierce (3-2) | Seventh | 15½ out |
| » Lost to Athletics (59-84), 5-2 | Cleveland Stadium (34-39) | 67-78 | |
| » W: Chuck Dobson (9-9) L: Steve Bailey (2-5) | Seventh | 15½ out |
| Tuesday, September 12 |
| » Defeated White Sox (80-65), 4-3 | Comiskey Park I (2-4) | 68-78 | |
| » W: Sam McDowell (12-13) L: Steve Jones (2-2) S: Orlando Pena (5) | Sixth | 14½ out |
| » Defeated White Sox (80-66), 7-1 | Comiskey Park I (3-4) | 69-78 | Won 2 |
| » W: Luis Tiant (10-9) L: Tommy John (9-11) | Sixth | 14½ out |
| Wednesday, September 13 |
| » Lost to White Sox (81- |