| Thursday, January 5 |
| Future Cub Chris Nabholz is born in Harrisburg, PA. |
| Thursday, February 9 |
| Future Cub Todd Pratt is born in Bellevue, NE. |
| Sunday, February 12 |
| Former Cub Bob Rhoads dies in San Bernardino, CA at the age of 88. |
| Tuesday, February 14 |
| Former Cub Jimmy Johnston dies in Chattanooga, TN at the age of 78. |
| Monday, March 27 |
| Future Cub Jaime Navarro is born in Bayamon, P.R. |
| Tuesday, March 28 |
| Future Cub Shawn Boskie is born in Hawthorne, NV. |
| Tuesday, April 11 |
| » Defeated Phillies (0-1), 4-2 | Wrigley Field (1-0) | 1-0 | |
| » Starters: Jim Bunning vs Fergie Jenkins | First | -- |
| Wednesday, April 12 |
| » Lost to Phillies (1-1), 5-4 | Wrigley Field (1-1) | 1-1 | |
| » Starters: Larry Jackson vs Ken Holtzman | Third | 1 out |
| Thursday, April 13 |
| Former Cub Tommy Griffith dies in Cincinnati, OH at the age of 78. |
| Friday, April 14 |
| » Defeated Pirates (1-2), 8-5 | Forbes Field (1-0) | 2-1 | |
| » Starters: Curt Simmons vs Dennis Ribant | Third | ½ out |
| Saturday, April 15 |
| » Defeated Pirates (1-3), 7-3 | Forbes Field (2-0) | 3-1 | Won 2 |
| » Starters: Ray Culp vs Tommie Sisk | Second | ½ out |
| Sunday, April 16 |
| » Lost to Pirates (2-3), 6-5 | Forbes Field (2-1) | 3-2 | |
| » Starters: Fergie Jenkins vs Bob Veale | Fourth | 1½ out |
| » Major-league debuts: Joe Niekro (Cubs) |
| Tuesday, April 18 |
| » Defeated Phillies (4-2), 8-4 | Shibe Park (1-0) | 4-2 | |
| » Starters: Ken Holtzman vs Chris Short | Third | 1½ out |
| Thursday, April 20 |
| » Lost to Mets (3-4), 6-1 | Shea Stadium (0-1) | 4-3 | |
| » Starters: Curt Simmons vs Tom Seaver | Fifth | 2 out |
| » Major-league debuts: Clarence Jones (Cubs) |
| Friday, April 21 |
| » Lost to Pirates (3-4), 6-1 | Wrigley Field (1-2) | 4-4 | Lost 2 |
| » Starters: Bob Veale vs Ray Culp | Fifth | 2½ out |
| Saturday, April 22 |
| Former Cub Bill Salkeld dies in Los Angeles, CA at the age of 51. |
| Sunday, April 23 |
| » Defeated Pirates (3-5), 7-3 | Wrigley Field (2-2) | 5-4 | |
| » Starters: Juan Pizarro vs Fergie Jenkins | Fourth | 2 out |
| Tuesday, April 25 |
| » Lost to Mets (5-7), 2-1 | Wrigley Field (2-3) | 5-5 | |
| » Starters: Tom Seaver vs Ken Holtzman | Fifth | 2½ out |
| Thursday, April 27 |
| » Defeated Mets (5-8), 3-0 | Wrigley Field (3-3) | 6-5 | |
| » Starters: Jack Fisher vs Fergie Jenkins | Fourth | 3½ out |
| Friday, April 28 |
| » Lost to Astros (5-11), 5-4 | Astrodome (0-1) | 6-6 | |
| » Starters: Curt Simmons vs Don Wilson | Fifth | 4½ out |
| Saturday, April 29 |
| » Defeated Astros (5-12), 4-1 | Astrodome (1-1) | 7-6 | |
| » Starters: Ken Holtzman vs Dave Giusti | Fifth | 4½ out |
| Former Cub Johnny Butler dies in Seal Beach, CA at the age of 75. |
| Sunday, April 30 |
| » Defeated Astros (5-13), 4-1 | Astrodome (2-1) | 8-6 | Won 2 |
| » Starters: Rich Nye vs Bo Belinsky | Fourth | 4 out |
| Tuesday, May 2 |
| » Lost to Braves (10-7), 3-1 | Atlanta-Fulton County Stadium (0-1) | 8-7 | |
| » Starters: Fergie Jenkins vs Denny Lemaster | Fourth | 4 out |
| Wednesday, May 3 |
| » Lost to Braves (11-7), 4-0 | Atlanta-Fulton County Stadium (0-2) | 8-8 | Lost 2 |
| » Starters: Ray Culp vs Dick Kelley | Fourth | 4 out |
| Friday, May 5 |
| » Defeated Cardinals (11-8), 5-3 | Wrigley Field (4-3) | 9-8 | |
| » Starters: Dick Hughes vs Ken Holtzman | Fourth | 4 out |
| Saturday, May 6 |
| » Lost to Cardinals (12-8), 5-3 | Wrigley Field (4-4) | 9-9 | |
| » Starters: Al Jackson vs Curt Simmons | Fifth | 5 out |
| Sunday, May 7 |
| » Defeated Cardinals (12-9), 5-4 | Wrigley Field (5-4) | 10-9 | |
| » Starters: Bob Gibson vs Rich Nye | Fourth | 4 out |
| Monday, May 8 |
| » Lost to Giants (10-12), 9-2 | Wrigley Field (5-5) | 10-10 | |
| » Starters: Juan Marichal vs Fergie Jenkins | Fifth | 4½ out |
| Tuesday, May 9 |
| » Defeated Giants (10-13), 10-2 | Wrigley Field (6-5) | 11-10 | |
| » Starters: Bobby Bolin vs Ray Culp | Fifth | 3½ out |
| Wednesday, May 10 |
| » Defeated Giants (10-14), 5-4 | Wrigley Field (7-5) | 12-10 | Won 2 |
| » Starters: Gaylord Perry vs Ken Holtzman | Fourth | 3½ out |
| Friday, May 12 |
| » Defeated Dodgers (9-15), 2-1 | Dodger Stadium (1-0) | 13-10 | Won 3 |
| » Starters: Curt Simmons vs Claude Osteen | Fourth | 3½ out |
| Saturday, May 13 |
| » Defeated Dodgers (9-16), 6-3 | Dodger Stadium (2-0) | 14-10 | Won 4 |
| » Starters: Fergie Jenkins vs Don Sutton | Fourth | 2½ out |
| Sunday, May 14 |
| » Lost to Dodgers (10-16), 2-1 | Dodger Stadium (2-1) | 14-11 | |
| » Starters: Rich Nye vs Don Drysdale | Third | 3½ out |
| » Defeated Dodgers (10-17), 6-3 | Dodger Stadium (3-1) | 15-11 | |
| » Starters: Ken Holtzman vs Bill Singer | Third | 3½ out |
| Former Cub Vic Saier dies in E.Lansing, MI at the age of 77. |
| Monday, May 15 |
| » Defeated Giants (14-15), 9-3 | Candlestick Park (1-0) | 16-11 | Won 2 |
| » Starters: Ray Culp vs Ron Herbel | Third | 3½ out |
| Tuesday, May 16 |
| » Lost to Giants (15-15), 3-1 | Candlestick Park (1-1) | 16-12 | |
| » Starters: Fergie Jenkins vs Juan Marichal | Third | 4½ out |
| Wednesday, May 17 |
| » Lost to Giants (16-15), 4-2 | Candlestick Park (1-2) | 16-13 | Lost 2 |
| » Starters: Curt Simmons vs Mike McCormick | Fourth | 5½ out |
| Thursday, May 18 |
| Future Cub Eric Young is born in New Brunswick, NJ. |
| Friday, May 19 |
| » Lost to Dodgers (13-18), 8-0 | Wrigley Field (7-6) | 16-14 | Lost 3 |
| » Starters: Don Drysdale vs Rich Nye | Fourth | 6 out |
| Future Cub Turk Wendell is born in Pittsfield, MA. |
| Saturday, May 20 |
| » Defeated Dodgers (13-19), 20-3 | Wrigley Field (8-6) | 17-14 | |
| » Starters: Claude Osteen vs Ken Holtzman | Fourth | 6 out |
| Sunday, May 21 |
| » Lost to Dodgers (14-19), 6-1 | Wrigley Field (8-7) | 17-15 | |
| » Starters: Jim Brewer vs Ray Culp | Fourth | 5½ out |
| » Defeated Dodgers (14-20), 8-2 | Wrigley Field (9-7) | 18-15 | |
| » Starters: Don Sutton vs Fergie Jenkins | Fourth | 5½ out |
| Wednesday, May 24 |
| » Lost to Reds (27-12), 4-3 | Wrigley Field (9-8) | 18-16 | |
| » Starters: Sammy Ellis vs Rich Nye | Fifth | 5½ out |
| » Defeated Reds (27-13), 4-3 | Wrigley Field (10-8) | 19-16 | |
| » Starters: Billy McCool vs Joe Niekro | Fifth | 5½ out |
| Thursday, May 25 |
| » Defeated Reds (27-14), 5-4 | Wrigley Field (11-8) | 20-16 | Won 2 |
| » Starters: Jim Maloney vs Fergie Jenkins | Fourth | 4½ out |
| Friday, May 26 |
| » Lost to Astros (13-27), 17-4 | Wrigley Field (11-9) | 20-17 | |
| » Starters: Dave Giusti vs Ray Culp | Fifth | 4½ out |
| Saturday, May 27 |
| » Lost to Astros (14-27), 2-1 | Wrigley Field (11-10) | 20-18 | Lost 2 |
| » Starters: Mike Cuellar vs Curt Simmons | Fifth | 5½ out |
| Tuesday, May 30 |
| » Defeated Braves (21-21), 12-5 | Wrigley Field (12-10) | 21-18 | |
| » Starters: Dick Kelley vs Fergie Jenkins | Fifth | 5½ out |
| » Lost to Braves (22-21), 4-1 | Wrigley Field (12-11) | 21-19 | |
| » Starters: Ken Johnson vs Joe Niekro | Fifth | 5½ out |
| Wednesday, May 31 |
| » Defeated Reds (30-18), 6-5 | Crosley Field (1-0) | 22-19 | |
| » Starters: Rich Nye vs Milt Pappas | Fifth | 4½ out |
| Thursday, June 1 |
| » Lost to Reds (31-18), 7-6 | Crosley Field (1-1) | 22-20 | |
| » Starters: Ray Culp vs Gary Nolan | Fifth | 5½ out |
| Friday, June 2 |
| » Lost to Cardinals (26-16), 2-1 | Busch Stadium II (0-1) | 22-21 | Lost 2 |
| » Starters: Curt Simmons vs Steve Carlton | Fifth | 6½ out |
| Saturday, June 3 |
| » Defeated Cardinals (26-17), 7-5 | Busch Stadium II (1-1) | 23-21 | |
| » Starters: Fergie Jenkins vs Bob Gibson | Fifth | 6½ out |
| Sunday, June 4 |
| » Lost to Cardinals (27-17), 4-3 | Busch Stadium II (1-2) | 23-22 | |
| » Starters: Rich Nye vs Dick Hughes | Fifth | 7½ out |
| Future Cub Scott Servais is born in LaCrosse, WI. Future Cub Rick Wilkins is born in Jacksonville, FL. |
| Monday, June 5 |
| » Defeated Phillies (22-24), 13-3 | Shibe Park (2-0) | 24-22 | |
| » Starters: Ray Culp vs Larry Jackson | Fifth | 7 out |
| Tuesday, June 6 |
| » Lost to Phillies (23-24), 8-6 | Shibe Park (2-1) | 24-23 | |
| » Starters: Curt Simmons vs John Boozer | Fifth | 8½ out |
| » Lost to Phillies (24-24), 9-8 | Shibe Park (2-2) | 24-24 | Lost 2 |
| » Starters: Joe Niekro vs Dick Ellsworth | Fifth | 8½ out |
| Wednesday, June 7 |
| » Defeated Phillies (24-25), 3-1 | Shibe Park (3-2) | 25-24 | |
| » Starters: Fergie Jenkins vs Jim Bunning | Fifth | 7½ out |
| Friday, June 9 |
| » Defeated Mets (17-32), 6-5 | Wrigley Field (13-11) | 26-24 | Won 2 |
| » Starters: Bob Shaw vs Rich Nye | Fifth | 7 out |
| Sunday, June 11 |
| » Defeated Mets (17-33), 5-3 | Wrigley Field (14-11) | 27-24 | Won 3 |
| » Starters: Jack Fisher vs Fergie Jenkins | Fifth | 6½ out |
| » Defeated Mets (17-34), 18-10 | Wrigley Field (15-11) | 28-24 | Won 4 |
| » Starters: Nick Willhite vs Curt Simmons | Fifth | 6½ out |
| Tuesday, June 13 |
| » Defeated Dodgers (21-35), 3-2 | Wrigley Field (16-11) | 29-24 | Won 5 |
| » Starters: Don Drysdale vs Rich Nye | Fourth | 6 out |
| Wednesday, June 14 |
| » Lost to Dodgers (22-35), 4-3 | Wrigley Field (16-12) | 29-25 | |
| » Starters: Claude Osteen vs Ray Culp | Fourth | 6 out |
| Future Cub Jerry Spradlin is born in Fullerton, CA. |
| Thursday, June 15 |
| » Lost to Dodgers (23-35), 5-0 | Wrigley Field (16-13) | 29-26 | Lost 2 |
| » Starters: Jim Brewer vs Fergie Jenkins | Fifth | 6½ out |
| Friday, June 16 |
| » Defeated Mets (19-36), 4-3 | Shea Stadium (1-1) | 30-26 | |
| » Starters: Curt Simmons vs Dick Selma | Fourth | 6½ out |
| Saturday, June 17 |
| » Defeated Mets (19-37), 9-1 | Shea Stadium (2-1) | 31-26 | Won 2 |
| » Starters: Rich Nye vs Bill Denehy | Fourth | 5½ out |
| Sunday, June 18 |
| » Lost to Mets (20-37), 4-3 | Shea Stadium (2-2) | 31-27 | |
| » Starters: Bill Hands vs Bob Shaw | Third | 4½ out |
| » Defeated Mets (20-38), 4-3 | Shea Stadium (3-2) | 32-27 | |
| » Starters: Rob Gardner vs Tom Seaver | Third | 4½ out |
| Monday, June 19 |
| » Lost to Pirates (33-27), 4-3 | Forbes Field (2-2) | 32-28 | |
| » Starters: Fergie Jenkins vs Bob Veale | Fifth | 5½ out |
| Tuesday, June 20 |
| » Defeated Pirates (33-28), 5-3 | Forbes Field (3-2) | 33-28 | |
| » Starters: Joe Niekro vs Steve Blass | Fourth | 5½ out |
| Wednesday, June 21 |
| » Defeated Pirates (33-29), 6-3 | Forbes Field (4-2) | 34-28 | Won 2 |
| » Starters: Curt Simmons vs Billy O'Dell | Third | 5½ out |
| Friday, June 23 |
| » Defeated Astros (26-42), 9-8 | Wrigley Field (17-13) | 35-28 | Won 3 |
| » Starters: Dave Giusti vs Rich Nye | Third | 6 out |
| Saturday, June 24 |
| » Defeated Astros (26-43), 3-2 | Wrigley Field (18-13) | 36-28 | Won 4 |
| » Starters: Mike Cuellar vs Fergie Jenkins | Third | 6 out |
| Sunday, June 25 |
| » Defeated Astros (26-44), 4-1 | Wrigley Field (19-13) | 37-28 | Won 5 |
| » Starters: Don Wilson vs Bill Hands | Third | 4 out |
| » Defeated Astros (26-45), 8-0 | Wrigley Field (20-13) | 38-28 | Won 6 |
| » Starters: Bo Belinsky vs Joe Niekro | Third | 4 out |
| Monday, June 26 |
| » Defeated Phillies (31-36), 4-2 | Wrigley Field (21-13) | 39-28 | Won 7 |
| » Starters: Turk Farrell vs Rich Nye | Third | 4 out |
| Tuesday, June 27 |
| » Lost to Phillies (32-36), 4-2 | Wrigley Field (21-14) | 39-29 | |
| » Starters: Rick Wise vs Curt Simmons | Third | 4 out |
| Wednesday, June 28 |
| » Defeated Pirates (35-33), 4-2 | Wrigley Field (22-14) | 40-29 | |
| » Starters: Dennis Ribant vs Fergie Jenkins | Second | 2½ out |
| » Defeated Pirates (35-34), 3-1 | Wrigley Field (23-14) | 41-29 | Won 2 |
| » Starters: Tommie Sisk vs Ray Culp | Second | 2½ out |
| Future Cub Matt Karchner is born in Berwick, PA. |
| Thursday, June 29 |
| » Defeated Pirates (35-35), 4-3 | Wrigley Field (24-14) | 42-29 | Won 3 |
| » Starters: Al McBean vs Joe Niekro | Second | 1½ out |
| Friday, June 30 |
| » Defeated Reds (43-33), 7-5 | Wrigley Field (25-14) | 43-29 | Won 4 |
| » Starters: Jim Maloney vs Bill Hands | Second | 1½ out |
| Saturday, July 1 |
| » Defeated Reds (43-34), 6-3 | Wrigley Field (26-14) | 44-29 | Won 5 |
| » Starters: Mel Queen vs Rich Nye | Second | ½ out |
| Sunday, July 2 |
| » Defeated Reds (43-35), 4-1 | Wrigley Field (27-14) | 45-29 | Won 6 |
| » Starters: Sammy Ellis vs Fergie Jenkins | First | -- |
| Monday, July 3 |
| » Defeated Braves (38-37), 12-6 | Atlanta-Fulton County Stadium (1-2) | 46-29 | Won 7 |
| » Starters: Ray Culp vs Tony Cloninger | First | -- |
| Tuesday, July 4 |
| » Lost to Braves (39-37), 8-3 | Atlanta-Fulton County Stadium (1-3) | 46-30 | |
| » Starters: Joe Niekro vs Phil Niekro | Second | ½ out |
| » Lost to Braves (40-37), 4-2 | Atlanta-Fulton County Stadium (1-4) | 46-31 | Lost 2 |
| » Starters: Bill Hands vs Denny Lemaster | Second | ½ out |
| Wednesday, July 5 |
| » Lost to Braves (41-37), 4-2 | Atlanta-Fulton County Stadium (1-5) | 46-32 | Lost 3 |
| » Starters: Rich Nye vs Ken Johnson | Second | ½ out |
| Future Cub Tim Worrell is born in Pasadena, CA. |
| Thursday, July 6 |
| » Lost to Astros (30-50), 4-3 | Astrodome (2-2) | 46-33 | Lost 4 |
| » Starters: Fergie Jenkins vs Bo Belinsky | Second | 1½ out |
| Friday, July 7 |
| » Lost to Astros (31-50), 11-5 | Astrodome (2-3) | 46-34 | Lost 5 |
| » Starters: Curt Simmons vs Wade Blasingame | Second | 2½ out |
| Saturday, July 8 |
| » Lost to Astros (32-50), 3-1 | Astrodome (2-4) | 46-35 | Lost 6 |
| » Starters: Ray Culp vs Dave Giusti | Second | 3½ out |
| Sunday, July 9 |
| » Lost to Astros (33-50), 6-0 | Astrodome (2-5) | 46-36 | Lost 7 |
| » Starters: Rich Nye vs Don Wilson | Second | 3½ out |
| Thursday, July 13 |
| » Defeated Dodgers (34-48), 2-1 | Dodger Stadium (4-1) | 47-36 | |
| » Starters: Rich Nye vs Don Sutton | Second | 3 out |
| Friday, July 14 |
| » Lost to Dodgers (35-48), 5-2 | Dodger Stadium (4-2) | 47-37 | |
| » Starters: Rob Gardner vs Bill Singer | Second | 4 out |
| Saturday, July 15 |
| » Lost to Dodgers (36-48), 5-1 | Dodger Stadium (4-3) | 47-38 | Lost 2 |
| » Starters: Fergie Jenkins vs Don Drysdale | Second | 4 out |
| Sunday, July 16 |
| » Defeated Giants (47-40), 9-0 | Candlestick Park (2-2) | 48-38 | |
| » Starters: Ray Culp vs Gaylord Perry | Second | 2 out |
| » Defeated Giants (47-41), 3-2 | Candlestick Park (3-2) | 49-38 | Won 2 |
| » Starters: Bill Stoneman vs Ron Herbel | Second | 2 out |
| » Major-league debuts: Bill Stoneman (Cubs) |
| Monday, July 17 |
| » Defeated Giants (47-42), 4-3 | Candlestick Park (4-2) | 50-38 | Won 3 |
| » Starters: Rich Nye vs Ray Sadecki | Second | 2 out |
| Tuesday, July 18 |
| » Defeated Braves (46-40), 9-3 | Wrigley Field (28-14) | 51-38 | Won 4 |
| » Starters: Denny Lemaster vs Fergie Jenkins | Second | 1 out |
| Wednesday, July 19 |
| » Defeated Braves (46-41), 7-2 | Wrigley Field (29-14) | 52-38 | Won 5 |
| » Starters: Tony Cloninger vs Joe Niekro | Second | 1 out |
| Thursday, July 20 |
| » Lost to Braves (47-41), 2-1 | Wrigley Field (29-15) | 52-39 | |
| » Starters: Pat Jarvis vs Ray Culp | Second | 2 out |
| Friday, July 21 |
| » Defeated Giants (49-45), 5-4 | Wrigley Field (30-15) | 53-39 | |
| » Starters: Ray Sadecki vs Bill Stoneman | Second | 1 out |
| Former Cub Jimmie Foxx dies in Miami, FL at the age of 60. |
| Saturday, July 22 |
| » Defeated Giants (49-46), 6-5 | Wrigley Field (31-15) | 54-39 | Won 2 |
| » Starters: Juan Marichal vs Rich Nye | First | -- |
| Sunday, July 23 |
| » Lost to Giants (50-46), 5-2 | Wrigley Field (31-16) | 54-40 | |
| » Starters: Mike McCormick vs Fergie Jenkins | Second | 1 out |
| » Defeated Giants (50-47), 6-3 | Wrigley Field (32-16) | 55-40 | |
| » Starters: Joe Gibbon vs Joe Niekro | Second | 1 out |
| Monday, July 24 |
| » Defeated Cardinals (56-40), 3-1 | Busch Stadium II (2-2) | 56-40 | Won 2 |
| » Starters: Ray Culp vs Larry Jaster | First | -- |
| Tuesday, July 25 |
| » Lost to Cardinals (57-40), 4-3 | Busch Stadium II (2-3) | 56-41 | |
| » Starters: Rob Gardner vs Ray Washburn | Second | 1 out |
| Wednesday, July 26 |
| » Lost to Cardinals (58-40), 4-2 | Busch Stadium II (2-4) | 56-42 | Lost 2 |
| » Starters: Rich Nye vs Nelson Briles | Second | 2 out |
| Friday, July 28 |
| » Defeated Reds (53-48), 6-2 | Crosley Field (2-1) | 57-42 | |
| » Starters: Fergie Jenkins vs Jim Maloney | Second | 2 out |
| Saturday, July 29 |
| » Lost to Reds (54-48), 4-2 | Crosley Field (2-2) | 57-43 | |
| » Starters: Ray Culp vs Milt Pappas | Second | 3 out |
| Sunday, July 30 |
| » Defeated Reds (54-49), 8-4 | Crosley Field (3-2) | 58-43 | |
| » Starters: Bob Shaw vs Gary Nolan | Second | 3½ out |
| » Lost to Reds (55-49), 3-2 | Crosley Field (3-3) | 58-44 | |
| » Starters: Joe Niekro vs Gerry Arrigo | Second | 3½ out |
| Monday, July 31 |
| » Lost to Cardinals (62-40), 9-2 | Wrigley Field (32-17) | 58-45 | Lost 2 |
| » Starters: Ray Washburn vs Rich Nye | Second | 4½ out |
| Tuesday, August 1 |
| » Defeated Cardinals (62-41), 3-2 | Wrigley Field (33-17) | 59-45 | |
| » Starters: Nelson Briles vs Fergie Jenkins | Second | 3½ out |
| Wednesday, August 2 |
| » Lost to Cardinals (63-41), 4-2 | Wrigley Field (33-18) | 59-46 | |
| » Starters: Dick Hughes vs Ray Culp | Second | 5½ out |
| » Lost to Cardinals (64-41), 7-1 | Wrigley Field (33-19) | 59-47 | Lost 2 |
| » Starters: Steve Carlton vs Bob Shaw | Second | 5½ out |
| Thursday, August 3 |
| » Lost to Braves (53-49), 10-3 | Wrigley Field (33-20) | 59-48 | Lost 3 |
| » Starters: Clay Carroll vs Joe Niekro | Second | 6 out |
| Friday, August 4 |
| » Lost to Braves (54-49), 6-3 | Wrigley Field (33-21) | 59-49 | Lost 4 |
| » Starters: Pat Jarvis vs Rich Nye | Second | 7 out |
| Saturday, August 5 |
| » Lost to Braves (55-49), 2-1 | Wrigley Field (33-22) | 59-50 | Lost 5 |
| » Starters: Phil Niekro vs Fergie Jenkins | Second | 8 out |
| Sunday, August 6 |
| » Lost to Braves (56-49), 6-4 | Wrigley Field (33-23) | 59-51 | Lost 6 |
| » Starters: Ken Johnson vs Ray Culp | Third | 9 out |
| Monday, August 7 |
| » Lost to Pirates (52-54), 6-3 | Wrigley Field (33-24) | 59-52 | Lost 7 |
| » Starters: Woodie Fryman vs Bob Shaw | Fourth | 9 out |
| » Tied Pirates, 3-3 | Wrigley Field (33-24) | 59-52 | |
| » Starters: Dennis Ribant vs Bill Hands | Fourth | 9 out |
| Tuesday, August 8 |
| » Defeated Pirates (52-55), 8-4 | Wrigley Field (34-24) | 60-52 | |
| » Starters: John Gelnar vs Joe Niekro | Second | 8 out |
| Wednesday, August 9 |
| » Defeated Pirates (52-56), 6-0 | Wrigley Field (35-24) | 61-52 | Won 2 |
| » Starters: Bob Veale vs Fergie Jenkins | Second | 8½ out |
| » Lost to Pirates (53-56), 10-6 | Wrigley Field (35-25) | 61-53 | |
| » Starters: Vern Law vs Ray Culp | Second | 8½ out |
| Thursday, August 10 |
| » Defeated Phillies (55-52), 3-2 | Wrigley Field (36-25) | 62-53 | |
| » Starters: Larry Jackson vs Rob Gardner | Second | 7½ out |
| Friday, August 11 |
| » Lost to Phillies (56-52), 2-1 | Wrigley Field (36-26) | 62-54 | |
| » Starters: Jim Bunning vs Bill Hands | Second | 8½ out |
| » Major-league debuts: Jim Ellis (Cubs) |
| Saturday, August 12 |
| » Lost to Phillies (57-52), 9-0 | Wrigley Field (36-27) | 62-55 | Lost 2 |
| » Starters: Dick Ellsworth vs Joe Niekro | Third | 9½ out |
| Sunday, August 13 |
| » Defeated Phillies (57-53), 6-2 | Wrigley Field (37-27) | 63-55 | |
| » Starters: John Boozer vs Ken Holtzman | Third | 9 out |
| » Defeated Phillies (57-54), 1-0 | Wrigley Field (38-27) | 64-55 | Won 2 |
| » Starters: Rick Wise vs Fergie Jenkins | Third | 9 out |
| Monday, August 14 |
| » Lost to Cardinals (72-44), 6-5 | Busch Stadium II (2-5) | 64-56 | |
| » Starters: Ray Culp vs Larry Jaster | Third | 10 out |
| Tuesday, August 15 |
| » Lost to Cardinals (73-44), 6-4 | Busch Stadium II (2-6) | 64-57 | Lost 2 |
| » Starters: Rich Nye vs Ray Washburn | Fifth | 11 out |
| Wednesday, August 16 |
| » Lost to Cardinals (74-44), 4-3 | Busch Stadium II (2-7) | 64-58 | Lost 3 |
| » Starters: Joe Niekro vs Nelson Briles | Fourth | 12 out |
| Future Cub Bret Barberie is born in Long Beach, CA. |
| Thursday, August 17 |
| » Lost to Phillies (60-56), 5-2 | Shibe Park (3-3) | 64-59 | Lost 4 |
| » Starters: Fergie Jenkins vs Rick Wise | Fifth | 12½ out |
| Friday, August 18 |
| » Defeated Phillies (60-57), 3-1 | Shibe Park (4-3) | 65-59 | |
| » Starters: Jim Ellis vs Larry Jackson | Fifth | 12½ out |
| Saturday, August 19 |
| » Defeated Phillies (60-58), 6-1 | Shibe Park (5-3) | 66-59 | Won 2 |
| » Starters: Rich Nye vs Jim Bunning | Fourth | 12½ out |
| Sunday, August 20 |
| » Defeated Phillies (60-59), 6-1 | Shibe Park (6-3) | 67-59 | Won 3 |
| » Starters: Ken Holtzman vs Chris Short | Third | 11½ out |
| Monday, August 21 |
| » Lost to Pirates (60-63), 5-1 | Forbes Field (4-3) | 67-60 | |
| » Starters: Fergie Jenkins vs Woodie Fryman | Third | 11½ out |
| Tuesday, August 22 |
| » Defeated Pirates (60-64), 8-1 | Forbes Field (5-3) | 68-60 | |
| » Starters: Joe Niekro vs Bob Veale | Third | 11½ out |
| Wednesday, August 23 |
| » Lost to Pirates (61-64), 2-1 | Forbes Field (5-4) | 68-61 | |
| » Starters: Bill Hands vs Al McBean | Third | 11½ out |
| Sunday, August 27 |
| » Defeated Mets (49-76), 3-1 | Shea Stadium (4-2) | 69-61 | |
| » Starters: Rich Nye vs Tom Seaver | Fourth | 11½ out |
| Future Cub Brian McRae is born in Bradenton, FL. |
| Monday, August 28 |
| » Defeated Astros (54-78), 6-5 | Wrigley Field (39-27) | 70-61 | Won 2 |
| » Starters: Bruce Von Hoff vs Fergie Jenkins | Third | 11 out |
| Tuesday, August 29 |
| » Lost to Astros (55-78), 5-3 | Wrigley Field (39-28) | 70-62 | |
| » Starters: Don Wilson vs Joe Niekro | Fourth | 11 out |
| Wednesday, August 30 |
| » Defeated Astros (55-79), 4-1 | Wrigley Field (40-28) | 71-62 | |
| » Starters: Mike Cuellar vs Bill Hands | Third | 11 out |
| Thursday, August 31 |
| » Defeated Mets (51-79), 2-1 | Wrigley Field (41-28) | 72-62 | Won 2 |
| » Starters: Tom Seaver vs Rich Nye | Third | 11 out |
| Friday, September 1 |
| » Defeated Mets (51-80), 8-2 | Wrigley Field (42-28) | 73-62 | Won 3 |
| » Starters: Jack Fisher vs Fergie Jenkins | Third | 11½ out |
| » Lost to Mets (52-80), 3-0 | Wrigley Field (42-29) | 73-63 | |
| » Starters: Don Cardwell vs Ray Culp | Third | 11½ out |
| Saturday, September 2 |
| » Defeated Mets (52-81), 5-0 | Wrigley Field (43-29) | 74-63 | |
| » Starters: Cal Koonce vs Joe Niekro | Third | 12 out |
| » Lost to Mets (53-81), 5-4 | Wrigley Field (43-30) | 74-64 | |
| » Starters: Bill Connors vs Dick Calmus | Third | 12 out |
| Sunday, September 3 |
| » Defeated Mets (53-82), 4-0 | Wrigley Field (44-30) | 75-64 | |
| » Starters: Bill Graham vs Bill Hands | Second | 11½ out |
| » Defeated Mets (53-83), 6-3 | Wrigley Field (45-30) | 76-64 | Won 2 |
| » Starters: Danny Frisella vs Ken Holtzman | Second | 11½ out |
| Future Cub Luis Gonzalez is born in Tampa, FL. |
| Monday, September 4 |
| » Defeated Dodgers (61-74), 2-1 | Wrigley Field (46-30) | 77-64 | Won 3 |
| » Starters: Claude Osteen vs Rich Nye | Second | 10½ out |
| » Lost to Dodgers (62-74), 8-6 | Wrigley Field (46-31) | 77-65 | |
| » Starters: Jim Brewer vs Rob Gardner | Second | 10½ out |
| Tuesday, September 5 |
| » Major-league debuts: Jerry Kenney (Yankees) |
| Wednesday, September 6 |
| » Lost to Dodgers (63-74), 6-3 | Dodger Stadium (4-4) | 77-66 | Lost 2 |
| » Starters: Fergie Jenkins vs Bill Singer | Third | 11½ out |
| Thursday, September 7 |
| » Defeated Dodgers (63-75), 3-2 | Dodger Stadium (5-4) | 78-66 | |
| » Starters: Bill Hands vs Don Drysdale | Third | 11½ out |
| Friday, September 8 |
| » Lost to Giants (77-64), 4-3 | Candlestick Park (4-3) | 78-67 | |
| » Starters: Joe Niekro vs Ray Sadecki | Third | 11½ out |
| Saturday, September 9 |
| » Defeated Giants (77-65), 8-2 | Candlestick Park (5-3) | 79-67 | |
| » Starters: Rich Nye vs Mike McCormick | Third | 11½ out |
| » Major-league debuts: Nestor Chavez (Giants) |
| Sunday, September 10 |
| » Lost to Giants (78-65), 2-1 | Candlestick Park (5-4) | 79-68 | |
| » Starters: Fergie Jenkins vs Gaylord Perry | Fourth | 11½ out |
| Monday, September 11 |
| » Lost to Astros (58-88), 11-10 | Astrodome (2-6) | 79-69 | Lost 2 |
| » Starters: Bill Hands vs Dave Giusti | Fourth | 12½ out |
| Tuesday, September 12 |
| » Lost to Astros (59-88), 5-4 | Astrodome (2-7) | 79-70 | Lost 3 |
| » Starters: Joe Niekro vs Bruce Von Hoff | Fourth | 13½ out |
| Wednesday, September 13 |
| Former Cub Joe Stanley dies in Detroit, MI at the age of 87. |
| Friday, September 15 |
| » Defeated Braves (74-73), 7-1 | Atlanta-Fulton County Stadium (2-5) | 80-70 | |
| » Starters: Fergie Jenkins vs Clay Carroll | Fourth | 13 out |
| Saturday, September 16 |
| » Defeated Braves (74-74), 3-2 | Atlanta-Fulton County Stadium (3-5) | 81-70 | Won 2 |
| » Starters: Rich Nye vs Ken Johnson | Fourth | 13 out |
| Sunday, September 17 |
| » Defeated Braves (74-75), 5-3 | Atlanta-Fulton County Stadium (4-5) | 82-70 | Won 3 |
| » Starters: Joe Niekro vs Denny Lemaster | Third | 13 out |
| Former Cub Karl Adams dies in Everett, WA at the age of 77. |
| Tuesday, September 19 |
| » Lost to Giants (82-68), 6-2 | Wrigley Field (46-32) | 82-71 | |
