| Wednesday, January 4 |
| Former Cardinal Estel Crabtree dies in Logan, OH at the age of 64. |
| Friday, January 13 |
| Former Cardinal Charley Gelbert dies in Easton, PA at the age of 61. |
| Sunday, February 12 |
| Former Cardinal Bob Rhoads dies in San Bernardino, CA at the age of 88. |
| Friday, February 17 |
| Future Cardinal Lonnie Maclin is born in Clayton, MO. |
| Sunday, February 26 |
| Future Cardinal David Howard is born in Sarasota, FL. |
| Wednesday, March 29 |
| Future Cardinal Brian Jordan is born in Baltimore, MD. Future Cardinal Geronimo Pena is born in Distrito Nacional, D.R. |
| Saturday, April 8 |
| Future Cardinal Rich Batchelor is born in Florence, SC. |
| Tuesday, April 11 |
| » Defeated Giants (0-1), 6-0 | Busch Stadium II (1-0) | 1-0 | |
| » Starters: Juan Marichal vs Bob Gibson | First | -- |
| Thursday, April 13 |
| » Major-league debuts: Tom Seaver (Mets) |
| Friday, April 14 |
| » Defeated Dodgers (0-2), 8-4 | Busch Stadium II (2-0) | 2-0 | Won 2 |
| » Starters: Claude Osteen vs Larry Jaster | First | -- |
| Saturday, April 15 |
| » Defeated Dodgers (0-3), 13-4 | Busch Stadium II (3-0) | 3-0 | Won 3 |
| » Starters: Don Sutton vs Al Jackson | First | -- |
| Sunday, April 16 |
| » Defeated Astros (3-3), 11-8 | Busch Stadium II (4-0) | 4-0 | Won 4 |
| » Starters: Mike Cuellar vs Bob Gibson | First | -- |
| Tuesday, April 18 |
| » Defeated Giants (1-6), 2-1 | Candlestick Park (1-0) | 5-0 | Won 5 |
| » Starters: Ray Washburn vs Gaylord Perry | First | -- |
| Wednesday, April 19 |
| » Defeated Giants (1-7), 7-5 | Candlestick Park (2-0) | 6-0 | Won 6 |
| » Starters: Larry Jaster vs Juan Marichal | First | -- |
| Thursday, April 20 |
| » Lost to Giants (2-7), 7-5 | Candlestick Park (2-1) | 6-1 | |
| » Starters: Al Jackson vs Bobby Bolin | First | -- |
| Saturday, April 22 |
| » Defeated Dodgers (2-6), 3-1 | Dodger Stadium (1-0) | 7-1 | |
| » Starters: Bob Gibson vs Don Drysdale | First | -- |
| Sunday, April 23 |
| » Lost to Dodgers (3-6), 9-3 | Dodger Stadium (1-1) | 7-2 | |
| » Starters: Ray Washburn vs Claude Osteen | First | -- |
| Future Cardinal Rheal Cormier is born in Moncton, NB. |
| Monday, April 24 |
| » Lost to Dodgers (4-6), 6-5 | Dodger Stadium (1-2) | 7-3 | Lost 2 |
| » Starters: Larry Jaster vs Don Sutton | Second | 1½ out |
| Tuesday, April 25 |
| » Defeated Astros (3-10), 4-0 | Astrodome (1-0) | 8-3 | |
| » Starters: Al Jackson vs Chris Zachary | First | -- |
| Wednesday, April 26 |
| » Defeated Astros (3-11), 7-2 | Astrodome (2-0) | 9-3 | Won 2 |
| » Starters: Steve Carlton vs Mike Cuellar | First | -- |
| Thursday, April 27 |
| » Lost to Astros (4-11), 6-4 | Astrodome (2-1) | 9-4 | |
| » Starters: Bob Gibson vs Larry Dierker | Second | 1½ out |
| Friday, April 28 |
| » Lost to Pirates (6-5), 6-2 | Busch Stadium II (4-1) | 9-5 | Lost 2 |
| » Starters: Bob Veale vs Ray Washburn | Second | 2½ out |
| Saturday, April 29 |
| Former Cardinal Johnny Butler dies in Seal Beach, CA at the age of 75. |
| Sunday, April 30 |
| » Lost to Pirates (7-5), 2-0 | Busch Stadium II (4-2) | 9-6 | Lost 3 |
| » Starters: Juan Pizarro vs Larry Jaster | Second | 3½ out |
| Monday, May 1 |
| » Lost to Pirates (8-5), 8-5 | Busch Stadium II (4-3) | 9-7 | Lost 4 |
| » Starters: Billy O'Dell vs Al Jackson | Fourth | 4 out |
| Tuesday, May 2 |
| » Defeated Reds (15-6), 5-0 | Busch Stadium II (5-3) | 10-7 | |
| » Starters: Jim Maloney vs Bob Gibson | Second | 3 out |
| Wednesday, May 3 |
| » Defeated Reds (15-7), 2-0 | Busch Stadium II (6-3) | 11-7 | Won 2 |
| » Starters: Milt Pappas vs Ray Washburn | Second | 2 out |
| Friday, May 5 |
| » Lost to Cubs (9-8), 5-3 | Wrigley Field (0-1) | 11-8 | |
| » Starters: Dick Hughes vs Ken Holtzman | Third | 3 out |
| Saturday, May 6 |
| » Defeated Cubs (9-9), 5-3 | Wrigley Field (1-1) | 12-8 | |
| » Starters: Al Jackson vs Curt Simmons | Third | 3 out |
| Sunday, May 7 |
| » Lost to Cubs (10-9), 5-4 | Wrigley Field (1-2) | 12-9 | |
| » Starters: Bob Gibson vs Rich Nye | Third | 3 out |
| Monday, May 8 |
| » Defeated Pirates (12-7), 6-5 | Forbes Field (1-0) | 13-9 | |
| » Starters: Ray Washburn vs Juan Pizarro | Third | 2½ out |
| Tuesday, May 9 |
| » Defeated Pirates (12-8), 6-3 | Forbes Field (2-0) | 14-9 | Won 2 |
| » Starters: Steve Carlton vs Woodie Fryman | Second | 1½ out |
| Wednesday, May 10 |
| » Lost to Pirates (13-8), 4-1 | Forbes Field (2-1) | 14-10 | |
| » Starters: Dick Hughes vs Bob Veale | Third | 2½ out |
| Friday, May 12 |
| » Defeated Mets (9-15), 7-5 | Busch Stadium II (7-3) | 15-10 | |
| » Starters: Tom Seaver vs Al Jackson | Third | 2½ out |
| Sunday, May 14 |
| » Lost to Mets (10-15), 3-1 | Busch Stadium II (7-4) | 15-11 | |
| » Starters: Jack Fisher vs Bob Gibson | Third | 3½ out |
| Tuesday, May 16 |
| » Defeated Phillies (13-15), 4-3 | Busch Stadium II (8-4) | 16-11 | |
| » Starters: Dick Ellsworth vs Ray Washburn | Second | 4 out |
| Wednesday, May 17 |
| » Defeated Phillies (13-16), 3-2 | Busch Stadium II (9-4) | 17-11 | Won 2 |
| » Starters: Chris Short vs Steve Carlton | Second | 4 out |
| Friday, May 19 |
| » Defeated Mets (10-18), 6-3 | Shea Stadium (1-0) | 18-11 | Won 3 |
| » Starters: Bob Gibson vs Jack Fisher | Second | 3½ out |
| Saturday, May 20 |
| » Defeated Mets (10-19), 11-9 | Shea Stadium (2-0) | 19-11 | Won 4 |
| » Starters: Al Jackson vs Jack Hamilton | Second | 3½ out |
| Sunday, May 21 |
| » Defeated Mets (10-20), 3-2 | Shea Stadium (3-0) | 20-11 | Won 5 |
| » Starters: Ray Washburn vs Don Cardwell | Second | 3½ out |
| Tuesday, May 23 |
| » Lost to Braves (19-16), 9-6 | Atlanta-Fulton County Stadium (0-1) | 20-12 | |
| » Starters: Steve Carlton vs Wade Blasingame | Second | 3 out |
| Wednesday, May 24 |
| » Lost to Braves (20-16), 2-0 | Atlanta-Fulton County Stadium (0-2) | 20-13 | Lost 2 |
| » Starters: Bob Gibson vs Denny Lemaster | Second | 3½ out |
| Future Cardinal Carlos Hernandez is born in San Felix, Venezuela. |
| Thursday, May 25 |
| » Defeated Braves (20-17), 5-0 | Atlanta-Fulton County Stadium (1-2) | 21-13 | |
| » Starters: Dick Hughes vs Dick Kelley | Second | 3½ out |
| Friday, May 26 |
| » Lost to Phillies (16-20), 7-4 | Shibe Park (0-1) | 21-14 | |
| » Starters: Ray Washburn vs Jim Bunning | Second | 3½ out |
| Saturday, May 27 |
| » Defeated Phillies (16-21), 11-4 | Shibe Park (1-1) | 22-14 | |
| » Starters: Larry Jaster vs Grant Jackson | Second | 3½ out |
| Sunday, May 28 |
| » Defeated Phillies (16-22), 8-3 | Shibe Park (2-1) | 23-14 | Won 2 |
| » Starters: Steve Carlton vs Larry Jackson | Second | 3½ out |
| Monday, May 29 |
| » Defeated Reds (28-17), 2-1 | Crosley Field (1-0) | 24-14 | Won 3 |
| » Starters: Bob Gibson vs Mel Queen | Second | 3½ out |
| » Lost to Reds (29-17), 7-6 | Crosley Field (1-1) | 24-15 | |
| » Starters: Al Jackson vs Billy McCool | Second | 3½ out |
| Tuesday, May 30 |
| » Lost to Reds (30-17), 2-1 | Crosley Field (1-2) | 24-16 | Lost 2 |
| » Starters: Dick Hughes vs Jim Maloney | Second | 3½ out |
| Thursday, June 1 |
| » Defeated Braves (22-22), 5-4 | Busch Stadium II (10-4) | 25-16 | |
| » Starters: Denny Lemaster vs Ray Washburn | Second | 4 out |
| Friday, June 2 |
| » Defeated Cubs (22-21), 2-1 | Busch Stadium II (11-4) | 26-16 | Won 2 |
| » Starters: Curt Simmons vs Steve Carlton | Second | 4 out |
| Saturday, June 3 |
| » Lost to Cubs (23-21), 7-5 | Busch Stadium II (11-5) | 26-17 | |
| » Starters: Fergie Jenkins vs Bob Gibson | Second | 4 out |
| Sunday, June 4 |
| » Defeated Cubs (23-22), 4-3 | Busch Stadium II (12-5) | 27-17 | |
| » Starters: Rich Nye vs Dick Hughes | Second | 4 out |
| Future Cardinal Rick Wilkins is born in Jacksonville, FL. |
| Monday, June 5 |
| » Lost to Astros (18-31), 5-2 | Busch Stadium II (12-6) | 27-18 | |
| » Starters: Dave Giusti vs Larry Jaster | Second | 3½ out |
| Future Cardinal Ray Lankford is born in Los Angeles, CA. |
| Tuesday, June 6 |
| » Lost to Astros (19-31), 3-2 | Busch Stadium II (12-7) | 27-19 | Lost 2 |
| » Starters: Mike Cuellar vs Ray Washburn | Second | 4½ out |
| Wednesday, June 7 |
| » Lost to Astros (20-31), 17-1 | Busch Stadium II (12-8) | 27-20 | Lost 3 |
| » Starters: Bo Belinsky vs Steve Carlton | Third | 4½ out |
| Thursday, June 8 |
| » Defeated Astros (20-32), 6-2 | Busch Stadium II (13-8) | 28-20 | |
| » Starters: Larry Dierker vs Bob Gibson | Third | 3½ out |
| Friday, June 9 |
| » Defeated Dodgers (21-31), 3-2 | Busch Stadium II (14-8) | 29-20 | Won 2 |
| » Starters: Claude Osteen vs Dick Hughes | Second | 3½ out |
| Saturday, June 10 |
| » Defeated Dodgers (21-32), 5-2 | Busch Stadium II (15-8) | 30-20 | Won 3 |
| » Starters: Jim Brewer vs Larry Jaster | Second | 3½ out |
| Sunday, June 11 |
| » Defeated Dodgers (21-33), 8-7 | Busch Stadium II (16-8) | 31-20 | Won 4 |
| » Starters: Bill Singer vs Ray Washburn | Second | 3½ out |
| » Defeated Dodgers (21-34), 7-5 | Busch Stadium II (17-8) | 32-20 | Won 5 |
| » Starters: Don Sutton vs Al Jackson | Second | 3½ out |
| Monday, June 12 |
| » Lost to Pirates (29-23), 7-5 | Forbes Field (2-2) | 32-21 | |
| » Starters: Steve Carlton vs Dennis Ribant | Second | 3 out |
| Tuesday, June 13 |
| » Defeated Pirates (29-24), 7-4 | Forbes Field (3-2) | 33-21 | |
| » Starters: Dick Hughes vs Tommie Sisk | Second | 3½ out |
| Former Cardinal Doug Baird dies in Thomasville, GA at the age of 76. |
| Wednesday, June 14 |
| » Defeated Pirates (29-25), 7-4 | Forbes Field (4-2) | 34-21 | Won 2 |
| » Starters: Bob Gibson vs Billy O'Dell | Second | 3½ out |
| Friday, June 16 |
| » Defeated Giants (32-27), 5-3 | Candlestick Park (3-1) | 35-21 | Won 3 |
| » Starters: Ray Washburn vs Lindy McDaniel | Second | 3½ out |
| Saturday, June 17 |
| » Lost to Giants (33-27), 3-2 | Candlestick Park (3-2) | 35-22 | |
| » Starters: Steve Carlton vs Joe Gibbon | Second | 3½ out |
| Sunday, June 18 |
| » Defeated Giants (33-28), 4-1 | Candlestick Park (4-2) | 36-22 | |
| » Starters: Dick Hughes vs Gaylord Perry | First | -- |
| Monday, June 19 |
| » Defeated Astros (26-39), 5-4 | Astrodome (3-1) | 37-22 | Won 2 |
| » Starters: Bob Gibson vs Mike Cuellar | First | -- |
| Tuesday, June 20 |
| » Defeated Astros (26-40), 6-2 | Astrodome (4-1) | 38-22 | Won 3 |
| » Starters: Larry Jaster vs Bo Belinsky | First | -- |
| Wednesday, June 21 |
| » Defeated Dodgers (27-37), 2-0 | Dodger Stadium (2-2) | 39-22 | Won 4 |
| » Starters: Ray Washburn vs Don Drysdale | First | -- |
| Thursday, June 22 |
| » Defeated Dodgers (27-38), 7-2 | Dodger Stadium (3-2) | 40-22 | Won 5 |
| » Starters: Steve Carlton vs Claude Osteen | First | -- |
| Friday, June 23 |
| » Defeated Phillies (29-34), 3-2 | Busch Stadium II (18-8) | 41-22 | Won 6 |
| » Starters: Rick Wise vs Dick Hughes | First | -- |
| Saturday, June 24 |
| » Defeated Phillies (29-35), 2-1 | Busch Stadium II (19-8) | 42-22 | Won 7 |
| » Starters: Larry Jackson vs Bob Gibson | First | -- |
| Sunday, June 25 |
| » Lost to Phillies (30-35), 6-4 | Busch Stadium II (19-9) | 42-23 | |
| » Starters: Jim Bunning vs Larry Jaster | First | -- |
| » Lost to Phillies (31-35), 10-4 | Busch Stadium II (19-10) | 42-24 | Lost 2 |
| » Starters: Dick Ellsworth vs Al Jackson | First | -- |
| Monday, June 26 |
| » Defeated Giants (36-34), 3-1 | Busch Stadium II (20-10) | 43-24 | |
| » Starters: Gaylord Perry vs Jim Cosman | First | -- |
| Tuesday, June 27 |
| » Lost to Giants (37-34), 6-0 | Busch Stadium II (20-11) | 43-25 | |
| » Starters: Mike McCormick vs Steve Carlton | First | -- |
| Wednesday, June 28 |
| » Lost to Giants (38-34), 9-1 | Busch Stadium II (20-12) | 43-26 | Lost 2 |
| » Starters: Ray Sadecki vs Dick Hughes | First | -- |
| Thursday, June 29 |
| » Lost to Giants (39-34), 12-4 | Busch Stadium II (20-13) | 43-27 | Lost 3 |
| » Starters: Joe Gibbon vs Bob Gibson | First | -- |
| Friday, June 30 |
| » Defeated Mets (25-44), 4-1 | Shea Stadium (4-0) | 44-27 | |
| » Starters: Larry Jaster vs Bob Shaw | First | -- |
| Saturday, July 1 |
| » Lost to Mets (26-44), 6-4 | Shea Stadium (4-1) | 44-28 | |
| » Starters: Jim Cosman vs Dennis Bennett | First | -- |
| Sunday, July 2 |
| » Lost to Mets (27-44), 5-4 | Shea Stadium (4-2) | 44-29 | Lost 2 |
| » Starters: Dick Hughes vs Bob Hendley | First | -- |
| » Defeated Mets (27-45), 3-1 | Shea Stadium (5-2) | 45-29 | |
| » Starters: Steve Carlton vs Jack Lamabe | First | -- |
| Monday, July 3 |
| » Defeated Reds (43-36), 7-3 | Busch Stadium II (21-13) | 46-29 | Won 2 |
| » Starters: Milt Pappas vs Bob Gibson | First | -- |
| Tuesday, July 4 |
| » Lost to Reds (44-36), 1-0 | Busch Stadium II (21-14) | 46-30 | |
| » Starters: Gary Nolan vs Larry Jaster | First | -- |
| Wednesday, July 5 |
| » Lost to Reds (45-36), 2-1 | Busch Stadium II (21-15) | 46-31 | Lost 2 |
| » Starters: Jim Maloney vs Jim Cosman | First | -- |
| Thursday, July 6 |
| » Defeated Reds (45-37), 6-5 | Busch Stadium II (22-15) | 47-31 | |
| » Starters: Mel Queen vs Dick Hughes | First | -- |
| Future Cardinal Omar Olivares is born in Mayaguez, P.R. |
| Friday, July 7 |
| » Defeated Phillies (39-39), 5-1 | Shibe Park (3-1) | 48-31 | Won 2 |
| » Starters: Steve Carlton vs Larry Jackson | First | -- |
| Saturday, July 8 |
| » Defeated Phillies (39-40), 6-4 | Shibe Park (4-1) | 49-31 | Won 3 |
| » Starters: Bob Gibson vs Chris Short | First | -- |
| Sunday, July 9 |
| » Lost to Phillies (40-40), 4-3 | Shibe Park (4-2) | 49-32 | |
| » Starters: Larry Jaster vs Jim Bunning | First | -- |
| Wednesday, July 12 |
| » Defeated Pirates (40-39), 4-3 | Busch Stadium II (23-15) | 50-32 | |
| » Starters: Steve Blass vs Dick Hughes | First | -- |
| Thursday, July 13 |
| » Lost to Pirates (41-39), 8-5 | Busch Stadium II (23-16) | 50-33 | |
| » Starters: Bob Veale vs Steve Carlton | First | -- |
| Friday, July 14 |
| » Defeated Pirates (41-40), 2-1 | Busch Stadium II (24-16) | 51-33 | |
| » Starters: Tommie Sisk vs Larry Jaster | First | -- |
| Saturday, July 15 |
| » Lost to Pirates (42-40), 6-4 | Busch Stadium II (24-17) | 51-34 | |
| » Starters: Dennis Ribant vs Bob Gibson | First | -- |
| Sunday, July 16 |
| » Lost to Mets (33-50), 2-1 | Busch Stadium II (24-18) | 51-35 | Lost 2 |
| » Starters: Dennis Bennett vs Ray Washburn | First | -- |
| » Lost to Mets (34-50), 8-5 | Busch Stadium II (24-19) | 51-36 | Lost 3 |
| » Starters: Dick Selma vs Jim Cosman | First | -- |
| Monday, July 17 |
| » Defeated Mets (34-51), 6-4 | Busch Stadium II (25-19) | 52-36 | |
| » Starters: Don Cardwell vs Dick Hughes | First | -- |
| Tuesday, July 18 |
| » Lost to Reds (51-41), 7-4 | Crosley Field (1-3) | 52-37 | |
| » Starters: Steve Carlton vs Jim Maloney | First | -- |
| Wednesday, July 19 |
| » Defeated Reds (51-42), 3-2 | Crosley Field (2-3) | 53-37 | |
| » Starters: Larry Jaster vs Gary Nolan | First | -- |
| Thursday, July 20 |
| » Defeated Reds (51-43), 7-3 | Crosley Field (3-3) | 54-37 | Won 2 |
| » Starters: Ray Washburn vs Mel Queen | First | -- |
| Friday, July 21 |
| » Lost to Braves (48-41), 4-1 | Busch Stadium II (25-20) | 54-38 | |
| » Starters: Phil Niekro vs Nelson Briles | First | -- |
| Future Cardinal Lance Painter is born in Bedford, England. |
| Saturday, July 22 |
| » Lost to Braves (49-41), 5-4 | Busch Stadium II (25-21) | 54-39 | Lost 2 |
| » Starters: Ken Johnson vs Dick Hughes | First | -- |
| Sunday, July 23 |
| » Defeated Braves (49-42), 3-1 | Busch Stadium II (26-21) | 55-39 | |
| » Starters: Denny Lemaster vs Steve Carlton | First | -- |
| » Defeated Braves (49-43), 8-3 | Busch Stadium II (27-21) | 56-39 | Won 2 |
| » Starters: Ed Rakow vs Jim Cosman | First | -- |
| Monday, July 24 |
| » Lost to Cubs (56-40), 3-1 | Busch Stadium II (27-22) | 56-40 | |
| » Starters: Ray Culp vs Larry Jaster | First | -- |
| Tuesday, July 25 |
| » Defeated Cubs (56-41), 4-3 | Busch Stadium II (28-22) | 57-40 | |
| » Starters: Rob Gardner vs Ray Washburn | First | -- |
| Wednesday, July 26 |
| » Defeated Cubs (56-42), 4-2 | Busch Stadium II (29-22) | 58-40 | Won 2 |
| » Starters: Rich Nye vs Nelson Briles | First | -- |
| Friday, July 28 |
| » Defeated Braves (51-45), 9-1 | Atlanta-Fulton County Stadium (2-2) | 59-40 | Won 3 |
| » Starters: Dick Hughes vs Denny Lemaster | First | -- |
| Saturday, July 29 |
| » Defeated Braves (51-46), 6-0 | Atlanta-Fulton County Stadium (3-2) | 60-40 | Won 4 |
| » Starters: Steve Carlton vs Tony Cloninger | First | -- |
| Sunday, July 30 |
| » Defeated Braves (51-47), 7-5 | Atlanta-Fulton County Stadium (4-2) | 61-40 | Won 5 |
| » Starters: Larry Jaster vs Pat Jarvis | First | -- |
| Monday, July 31 |
| » Defeated Cubs (58-45), 9-2 | Wrigley Field (2-2) | 62-40 | Won 6 |
| » Starters: Ray Washburn vs Rich Nye | First | -- |
| Tuesday, August 1 |
| » Lost to Cubs (59-45), 3-2 | Wrigley Field (2-3) | 62-41 | |
| » Starters: Nelson Briles vs Fergie Jenkins | First | -- |
| Future Cardinal Gregg Jefferies is born in Burlingame, CA. |
| Wednesday, August 2 |
| » Defeated Cubs (59-46), 4-2 | Wrigley Field (3-3) | 63-41 | |
| » Starters: Dick Hughes vs Ray Culp | First | -- |
| » Defeated Cubs (59-47), 7-1 | Wrigley Field (4-3) | 64-41 | Won 2 |
| » Starters: Steve Carlton vs Bob Shaw | First | -- |
| Friday, August 4 |
| » Defeated Reds (57-51), 5-0 | Busch Stadium II (30-22) | 65-41 | Won 3 |
| » Starters: Gary Nolan vs Larry Jaster | First | -- |
| Saturday, August 5 |
| » Defeated Reds (57-52), 4-3 | Busch Stadium II (31-22) | 66-41 | Won 4 |
| » Starters: Mel Queen vs Ray Washburn | First | -- |
| Sunday, August 6 |
| » Defeated Reds (57-53), 3-2 | Busch Stadium II (32-22) | 67-41 | Won 5 |
| » Starters: Jim Maloney vs Nelson Briles | First | -- |
| Monday, August 7 |
| » Lost to Dodgers (48-59), 6-4 | Busch Stadium II (32-23) | 67-42 | |
| » Starters: Bill Singer vs Steve Carlton | First | -- |
| Tuesday, August 8 |
| » Lost to Dodgers (49-59), 6-2 | Busch Stadium II (32-24) | 67-43 | Lost 2 |
| » Starters: Don Sutton vs Dick Hughes | First | -- |
| Wednesday, August 9 |
| » Defeated Dodgers (49-60), 3-2 | Busch Stadium II (33-24) | 68-43 | |
| » Starters: Don Drysdale vs Larry Jaster | First | -- |
| Thursday, August 10 |
| » Lost to Giants (60-52), 5-2 | Busch Stadium II (33-25) | 68-44 | |
| » Starters: Mike McCormick vs Ray Washburn | First | -- |
| Future Cardinal Chuck Carr is born in San Bernardino, CA. |
| Friday, August 11 |
| » Defeated Giants (60-53), 2-1 | Busch Stadium II (34-25) | 69-44 | |
| » Starters: Gaylord Perry vs Nelson Briles | First | -- |
| Saturday, August 12 |
| » Defeated Giants (60-54), 3-2 | Busch Stadium II (35-25) | 70-44 | Won 2 |
| » Starters: Joe Gibbon vs Steve Carlton | First | -- |
| Sunday, August 13 |
| » Defeated Giants (60-55), 2-1 | Busch Stadium II (36-25) | 71-44 | Won 3 |
| » Starters: Ray Sadecki vs Dick Hughes | First | -- |
| Monday, August 14 |
| » Defeated Cubs (64-56), 6-5 | Busch Stadium II (37-25) | 72-44 | Won 4 |
| » Starters: Ray Culp vs Larry Jaster | First | -- |
| Tuesday, August 15 |
| » Defeated Cubs (64-57), 6-4 | Busch Stadium II (38-25) | 73-44 | Won 5 |
| » Starters: Rich Nye vs Ray Washburn | First | -- |
| Future Cardinal Mike James is born in Fort Walton Beach, FL. |
| Wednesday, August 16 |
| » Defeated Cubs (64-58), 4-3 | Busch Stadium II (39-25) | 74-44 | Won 6 |
| » Starters: Joe Niekro vs Nelson Briles | First | -- |
| Friday, August 18 |
| » Defeated Astros (49-72), 5-3 | Astrodome (5-1) | 75-44 | Won 7 |
| » Starters: Steve Carlton vs Mike Cuellar | First | -- |
| Saturday, August 19 |
| » Defeated Astros (49-73), 7-4 | Astrodome (6-1) | 76-44 | Won 8 |
| » Starters: Dick Hughes vs Bruce Von Hoff | First | -- |
| Sunday, August 20 |
| » Lost to Astros (50-73), 2-1 | Astrodome (6-2) | 76-45 | |
| » Starters: Larry Jaster vs Don Wilson | First | -- |
| Future Cardinal Andy Benes is born in Evansville, IN. |
| Monday, August 21 |
| » Lost to Astros (51-73), 11-4 | Astrodome (6-3) | 76-46 | Lost 2 |
| » Starters: Ray Washburn vs Wade Blasingame | First | -- |
| Tuesday, August 22 |
| » Defeated Giants (64-59), 9-0 | Candlestick Park (5-2) | 77-46 | |
| » Starters: Nelson Briles vs Ray Sadecki | First | -- |
| Wednesday, August 23 |
| » Lost to Giants (65-59), 6-0 | Candlestick Park (5-3) | 77-47 | |
| » Starters: Steve Carlton vs Mike McCormick | First | -- |
| Thursday, August 24 |
| » Defeated Giants (65-60), 2-0 | Candlestick Park (6-3) | 78-47 | |
| » Starters: Dick Hughes vs Gaylord Perry | First | -- |
| Friday, August 25 |
| » Lost to Dodgers (58-66), 2-1 | Dodger Stadium (3-3) | 78-48 | |
| » Starters: Larry Jaster vs Bill Singer | First | -- |
| » Defeated Dodgers (58-67), 4-1 | Dodger Stadium (4-3) | 79-48 | |
| » Starters: Al Jackson vs Jim Brewer | First | -- |
| Saturday, August 26 |
| » Lost to Dodgers (59-67), 2-1 | Dodger Stadium (4-4) | 79-49 | |
| » Starters: Ray Washburn vs Don Drysdale | First | -- |
| Sunday, August 27 |
| » Defeated Dodgers (59-68), 6-2 | Dodger Stadium (5-4) | 80-49 | |
| » Starters: Nelson Briles vs Claude Osteen | First | -- |
| Future Cardinal Willie Smith is born in Savannah, GA. |
| Monday, August 28 |
| » Lost to Mets (50-76), 4-2 | Busch Stadium II (39-26) | 80-50 | |
| » Starters: Jack Fisher vs Steve Carlton | First | -- |
| » Defeated Mets (50-77), 6-0 | Busch Stadium II (40-26) | 81-50 | |
| » Starters: Bob Hendley vs Jack Lamabe | First | -- |
| Tuesday, August 29 |
| » Lost to Mets (51-77), 2-0 | Busch Stadium II (40-27) | 81-51 | |
| » Starters: Cal Koonce vs Dick Hughes | First | -- |
| Wednesday, August 30 |
| » Defeated Mets (51-78), 2-0 | Busch Stadium II (41-27) | 82-51 | |
| » Starters: Danny Frisella vs Larry Jaster | First | -- |
| Thursday, August 31 |
| » Defeated Astros (55-80), 5-1 | Busch Stadium II (42-27) | 83-51 | Won 2 |
| » Starters: Bo Belinsky vs Ray Washburn | First | -- |
| Future Cardinal Stan Royer is born in Olney, IL. |
| Friday, September 1 |
| » Defeated Astros (55-81), 5-0 | Busch Stadium II (43-27) | 84-51 | Won 3 |
| » Starters: Bruce Von Hoff vs Nelson Briles | First | -- |
| Saturday, September 2 |
| » Defeated Astros (55-82), 8-2 | Busch Stadium II (44-27) | 85-51 | Won 4 |
| » Starters: Dave Giusti vs Steve Carlton | First | -- |
| Sunday, September 3 |
| » Defeated Astros (55-83), 13-1 | Busch Stadium II (45-27) | 86-51 | Won 5 |
| » Starters: Don Wilson vs Dick Hughes | First | -- |
| Monday, September 4 |
| » Lost to Pirates (67-70), 10-8 | Busch Stadium II (45-28) | 86-52 | |
| » Starters: Bob Veale vs Larry Jaster | First | -- |
| » Lost to Pirates (68-70), 9-3 | Busch Stadium II (45-29) | 86-53 | Lost 2 |
| » Starters: Steve Blass vs Ray Washburn | First | -- |
| Wednesday, September 6 |
| » Defeated Mets (53-85), 3-1 | Shea Stadium (6-2) | 87-53 | |
| » Starters: Nelson Briles vs Jack Fisher | First | -- |
| » Major-league debuts: Amos Otis (Mets) |
| Thursday, September 7 |
| » Defeated Mets (53-86), 9-2 | Shea Stadium (7-2) | 88-53 | Won 2 |
| » Starters: Bob Gibson vs Cal Koonce | First | -- |
| Friday, September 8 |
| » Lost to Pirates (71-71), 4-3 | Forbes Field (4-3) | 88-54 | |
| » Starters: Dick Hughes vs Dennis Ribant | First | -- |
| Saturday, September 9 |
| » Defeated Pirates (71-72), 6-0 | Forbes Field (5-3) | 89-54 | |
| » Starters: Steve Carlton vs Steve Blass | First | -- |
| Sunday, September 10 |
| » Lost to Pirates (72-72), 8-7 | Forbes Field (5-4) | 89-55 | |
| » Starters: Ray Washburn vs Woodie Fryman | First | -- |
| » Major-league debuts: Mike Torrez (Cardinals) |
| Monday, September 11 |
| » Defeated Phillies (74-68), 5-1 | Busch Stadium II (46-29) | 90-55 | |
| » Starters: Chris Short vs Nelson Briles | First | -- |
| Tuesday, September 12 |
| » Defeated Phillies (74-69), 6-0 | Busch Stadium II (47-29) | 91-55 | Won 2 |
| » Starters: Rick Wise vs Bob Gibson | First | -- |
| Wednesday, September 13 |
| » Lost to Phillies (75-69), 3-0 | Busch Stadium II (47-30) | 91-56 | |
| » Starters: Larry Jackson vs Dick Hughes | First | -- |
| Thursday, September 14 |
| » Major-league debuts: Cito Gaston (Braves) |
| Friday, September 15 |
| » Defeated Reds (80-68), 4-0 | Crosley Field (4-3) | 92-56 | |
| » Starters: Steve Carlton vs Gary Nolan | First | -- |
| Saturday, September 16 |
| » Defeated Reds (80-69), 4-1 | Crosley Field (5-3) | 93-56 | Won 2 |
| » Starters: Ray Washburn vs Milt Pappas | First | -- |
| Sunday, September 17 |
| » Defeated Reds (80-70), 3-2 | Crosley Field (6-3) | 94-56 | Won 3 |
| » Starters: Nelson Briles vs Jim Maloney | First | -- |
| Monday, September 18 |
| » Defeated Phillies (77-72), 5-1 | Shibe Park (5-2) | 95-56 | Won 4 |
| » Starters: Bob Gibson vs Dick Ellsworth | First | -- |
| Tuesday, September 19 |
| » Defeated Phillies (77-73), 1-0 | Shibe Park (6-2) | 96-56 | Won 5 |
| » Starters: Dick Hughes vs Jim Bunning | First | -- |
| » Major-league debuts: Steve Huntz (Cardinals) |
| Wednesday, September 20 |
| » Lost to Phillies (78-73), 3-1 | Shibe Park (6-3) | 96-57 | |
| » Starters: Steve Carlton vs Chris Short | First | -- |
| Thursday, September 21 |
| » Lost to Braves (75-78), 4-2 | Busch Stadium II (47-31) | 96-58 | Lost 2 |
| » Starters: Ron Reed vs Ray Washburn | First | -- |
| Friday, September 22 |
| » Defeated Braves (75-79), 5-4 | Busch Stadium II (48-31) | 97-58 | |
|
