| Sunday, January 16 |
| Future White Sox Jack McDowell is born in Van Nuys, CA. |
| Tuesday, February 15 |
| Future White Sox Melido Perez is born in San Cristobal, D.R. |
| Friday, February 25 |
| Former White Sox Garland Braxton dies in Norfolk, VA at the age of 66. |
| Sunday, March 6 |
| Future White Sox Joe Hall is born in Paducah, KY. |
| Wednesday, March 9 |
| Former White Sox Aaron Robinson dies in Lancaster, SC at the age of 51. |
| Thursday, March 31 |
| Former White Sox Grady Adkins dies in Little Rock, AR at the age of 69. |
| Tuesday, April 12 |
| » Defeated Angels (0-1), 3-2 | Comiskey Park I (1-0) | 1-0 | |
| » Starters: Dean Chance vs Tommy John | First | -- |
| » Major-league debuts: Dennis Higgins (White Sox) Willie Montanez (Angels) |
| Wednesday, April 13 |
| » Major-league debuts: Joe Foy and Pete Magrini (Red Sox) |
| Thursday, April 14 |
| » Lost to Angels (1-1), 2-1 | Comiskey Park I (1-1) | 1-1 | |
| » Starters: Marcelino Lopez vs Joe Horlen | Fourth | 1½ out |
| Friday, April 15 |
| » Major-league debuts: Fritz Peterson (Yankees) |
| Saturday, April 16 |
| » Defeated Athletics (0-4), 2-1 | Comiskey Park I (2-1) | 2-1 | |
| » Starters: Catfish Hunter vs Gary Peters | Fourth | 2 out |
| Sunday, April 17 |
| » Defeated Athletics (0-5), 5-0 | Comiskey Park I (3-1) | 3-1 | Won 2 |
| » Starters: Rollie Sheldon vs John Buzhardt | Fourth | 1 out |
| Tuesday, April 19 |
| » Defeated Angels (3-2), 3-1 | Anaheim Stadium (1-0) | 4-1 | Won 3 |
| » Starters: Tommy John vs Marcelino Lopez | Third | 1 out |
| Wednesday, April 20 |
| » Lost to Angels (4-2), 4-3 | Anaheim Stadium (1-1) | 4-2 | |
| » Starters: Joe Horlen vs Dean Chance | Fourth | 2 out |
| Thursday, April 21 |
| » Defeated Angels (4-3), 8-6 | Anaheim Stadium (2-1) | 5-2 | |
| » Starters: Juan Pizarro vs Fred Newman | Third | 1½ out |
| » Major-league debuts: Jorge Rubio (Angels) |
| Saturday, April 23 |
| » Lost to Athletics (2-5), 2-1 | Municipal Stadium (0-1) | 5-3 | |
| » Starters: John Buzhardt vs Catfish Hunter | Fourth | 2½ out |
| » Major-league debuts: Lee Elia (White Sox) |
| Sunday, April 24 |
| » Defeated Athletics (2-6), 4-3 | Municipal Stadium (1-1) | 6-3 | |
| » Starters: Gary Peters vs Fred Talbot | Fourth | 2 out |
| Monday, April 25 |
| » Defeated Senators (2-8), 3-2 | Robert F. Kennedy Stadium (1-0) | 7-3 | Won 2 |
| » Starters: Tommy John vs Phil Ortega | Third | 2 out |
| Tuesday, April 26 |
| » Defeated Senators (2-9), 4-1 | Robert F. Kennedy Stadium (2-0) | 8-3 | Won 3 |
| » Starters: Joe Horlen vs Diego Segui | Third | 2 out |
| Wednesday, April 27 |
| » Defeated Red Sox (3-9), 8-6 | Fenway Park (1-0) | 9-3 | Won 4 |
| » Starters: John Buzhardt vs Jerry Stephenson | Third | 1½ out |
| Friday, April 29 |
| » Defeated Indians (10-1), 4-1 | Cleveland Stadium (1-0) | 10-3 | Won 5 |
| » Starters: Gary Peters vs Gary Bell | Second | 1 out |
| Future White Sox Ed Correa is born in Hato Rey, P.R. |
| Sunday, May 1 |
| » Lost to Indians (11-1), 1-0 | Cleveland Stadium (1-1) | 10-4 | |
| » Starters: Tommy John vs Sam McDowell | Third | 2½ out |
| Tuesday, May 3 |
| » Lost to Twins (6-7), 4-2 | Comiskey Park I (3-2) | 10-5 | Lost 2 |
| » Starters: Camilo Pascual vs Joe Horlen | Third | 3 out |
| Wednesday, May 4 |
| » Lost to Twins (7-7), 6-1 | Comiskey Park I (3-3) | 10-6 | Lost 3 |
| » Starters: Jim Kaat vs John Buzhardt | Third | 4 out |
| Former White Sox Bob Elliott dies in San Diego, CA at the age of 50. |
| Friday, May 6 |
| » Lost to Tigers (12-8), 1-0 | Comiskey Park I (3-4) | 10-7 | Lost 4 |
| » Starters: Denny McLain vs Gary Peters | Fifth | 4½ out |
| Saturday, May 7 |
| » Defeated Tigers (12-9), 1-0 | Comiskey Park I (4-4) | 11-7 | |
| » Starters: Joe Sparma vs Tommy John | Third | 4½ out |
| Sunday, May 8 |
| » Lost to Tigers (13-9), 3-1 | Comiskey Park I (4-5) | 11-8 | |
| » Starters: Hank Aguirre vs Joe Horlen | Third | 4 out |
| Tuesday, May 10 |
| » Lost to Orioles (16-4), 3-2 | Memorial Stadium (0-1) | 11-9 | Lost 2 |
| » Starters: Gary Peters vs John Miller | Fifth | 5 out |
| Wednesday, May 11 |
| » Defeated Orioles (16-5), 3-2 | Memorial Stadium (1-1) | 12-9 | |
| » Starters: Tommy John vs Dave McNally | Fifth | 4 out |
| » Major-league debuts: Gene Brabender (Orioles) |
| Thursday, May 12 |
| » Defeated Orioles (16-6), 5-3 | Memorial Stadium (2-1) | 13-9 | Won 2 |
| » Starters: Bruce Howard vs Frank Bertaina | Fourth | 3 out |
| Friday, May 13 |
| » Lost to Tigers (15-9), 5-4 | Tiger Stadium (0-1) | 13-10 | |
| » Starters: Joe Horlen vs Denny McLain | Fifth | 4 out |
| Saturday, May 14 |
| » Defeated Tigers (15-10), 13-3 | Tiger Stadium (1-1) | 14-10 | |
| » Starters: Gary Peters vs Mickey Lolich | Fifth | 4 out |
| Sunday, May 15 |
| » Lost to Tigers (16-10), 8-6 | Tiger Stadium (1-2) | 14-11 | |
| » Starters: Tommy John vs Hank Aguirre | Fifth | 4½ out |
| Tuesday, May 17 |
| » Lost to Twins (14-11), 8-3 | Metropolitan Stadium (0-1) | 14-12 | Lost 2 |
| » Starters: Joe Horlen vs Jim Kaat | Sixth | 5½ out |
| Wednesday, May 18 |
| » Lost to Twins (15-11), 7-1 | Metropolitan Stadium (0-2) | 14-13 | Lost 3 |
| » Starters: Gary Peters vs Mudcat Grant | Sixth | 5½ out |
| Thursday, May 19 |
| » Lost to Twins (16-11), 4-3 | Metropolitan Stadium (0-3) | 14-14 | Lost 4 |
| » Starters: John Buzhardt vs Jim Perry | Sixth | 5½ out |
| Friday, May 20 |
| » Lost to Indians (20-8), 3-2 | Comiskey Park I (4-6) | 14-15 | Lost 5 |
| » Starters: Gary Bell vs Tommy John | Sixth | 6½ out |
| Saturday, May 21 |
| » Defeated Indians (20-9), 7-2 | Comiskey Park I (5-6) | 15-15 | |
| » Starters: Sam McDowell vs Juan Pizarro | Sixth | 5½ out |
| Sunday, May 22 |
| » Lost to Indians (21-9), 3-2 | Comiskey Park I (5-7) | 15-16 | |
| » Starters: Sonny Siebert vs Gary Peters | Sixth | 7½ out |
| » Lost to Indians (22-9), 4-1 | Comiskey Park I (5-8) | 15-17 | Lost 2 |
| » Starters: John O'Donoghue vs Bruce Howard | Sixth | 7½ out |
| Tuesday, May 24 |
| » Lost to Orioles (20-14), 6-4 | Comiskey Park I (5-9) | 15-18 | Lost 3 |
| » Starters: Jim Palmer vs John Buzhardt | Sixth | 8 out |
| Wednesday, May 25 |
| » Defeated Orioles (20-15), 3-2 | Comiskey Park I (6-9) | 16-18 | |
| » Starters: Steve Barber vs Tommy John | Sixth | 8 out |
| Thursday, May 26 |
| » Lost to Orioles (21-15), 7-1 | Comiskey Park I (6-10) | 16-19 | |
| » Starters: Dave McNally vs Juan Pizarro | Fifth | 9 out |
| Friday, May 27 |
| » Lost to Yankees (17-20), 4-1 | Yankee Stadium (0-1) | 16-20 | Lost 2 |
| » Starters: Joe Horlen vs Mel Stottlemyre | Eighth | 10 out |
| Saturday, May 28 |
| » Tied Yankees, 2-2 | Yankee Stadium (0-1) | 16-20 | |
| » Starters: Bruce Howard vs Fritz Peterson | Seventh | 10½ out |
| Sunday, May 29 |
| » Defeated Yankees (17-21), 2-0 | Yankee Stadium (1-1) | 17-20 | |
| » Starters: Tommy John vs Bob Friend | Sixth | 9 out |
| Monday, May 30 |
| » Defeated Red Sox (16-25), 1-0 | Comiskey Park I (7-10) | 18-20 | Won 2 |
| » Starters: Earl Wilson vs John Buzhardt | Sixth | 7 out |
| » Defeated Red Sox (16-26), 11-0 | Comiskey Park I (8-10) | 19-20 | Won 3 |
| » Starters: Jose Santiago vs Jack Lamabe | Sixth | 7 out |
| Tuesday, May 31 |
| » Lost to Red Sox (17-26), 1-0 | Comiskey Park I (8-11) | 19-21 | |
| » Starters: Dick Stigman vs Joe Horlen | Sixth | 8 out |
| Wednesday, June 1 |
| » Defeated Yankees (18-24), 6-2 | Comiskey Park I (9-11) | 20-21 | |
| » Starters: Fritz Peterson vs Juan Pizarro | Fifth | 7 out |
| Thursday, June 2 |
| » Lost to Yankees (19-24), 5-3 | Comiskey Park I (9-12) | 20-22 | |
| » Starters: Bob Friend vs Tommy John | Sixth | 7 out |
| Friday, June 3 |
| » Defeated Senators (22-25), 8-0 | Comiskey Park I (10-12) | 21-22 | |
| » Starters: Mike McCormick vs Jack Lamabe | Fifth | 7 out |
| Saturday, June 4 |
| » Defeated Senators (22-26), 6-0 | Comiskey Park I (11-12) | 22-22 | Won 2 |
| » Starters: Pete Richert vs John Buzhardt | Fifth | 7 out |
| Sunday, June 5 |
| » Defeated Senators (22-27), 4-1 | Comiskey Park I (12-12) | 23-22 | Won 3 |
| » Starters: Diego Segui vs Joe Horlen | Fourth | 5½ out |
| » Defeated Senators (22-28), 12-0 | Comiskey Park I (13-12) | 24-22 | Won 4 |
| » Starters: Dick Bosman vs Gary Peters | Fourth | 5½ out |
| Monday, June 6 |
| » Defeated Angels (24-26), 5-1 | Anaheim Stadium (3-1) | 25-22 | Won 5 |
| » Starters: Juan Pizarro vs Jack Sanford | Fourth | 5 out |
| Tuesday, June 7 |
| » Lost to Angels (25-26), 3-2 | Anaheim Stadium (3-2) | 25-23 | |
| » Starters: Tommy John vs Marcelino Lopez | Fourth | 5 out |
| Wednesday, June 8 |
| » Lost to Angels (26-26), 1-0 | Anaheim Stadium (3-3) | 25-24 | Lost 2 |
| » Starters: Jack Lamabe vs George Brunet | Fourth | 6½ out |
| Friday, June 10 |
| » Lost to Twins (24-26), 6-2 | Comiskey Park I (13-13) | 25-25 | Lost 3 |
| » Starters: Dave Boswell vs John Buzhardt | Fourth | 8 out |
| Saturday, June 11 |
| » Lost to Twins (25-26), 4-3 | Comiskey Park I (13-14) | 25-26 | Lost 4 |
| » Starters: Jim Kaat vs Gary Peters | Fifth | 8 out |
| Sunday, June 12 |
| » Lost to Twins (26-26), 2-1 | Comiskey Park I (13-15) | 25-27 | Lost 5 |
| » Starters: Mudcat Grant vs Tommy John | Sixth | 9 out |
| Monday, June 13 |
| » Defeated Angels (27-29), 5-1 | Comiskey Park I (14-15) | 26-27 | |
| » Starters: George Brunet vs Jack Lamabe | Sixth | 9 out |
| » Lost to Angels (28-29), 2-1 | Comiskey Park I (14-16) | 26-28 | |
| » Starters: Minnie Rojas vs Joe Horlen | Sixth | 9 out |
| Tuesday, June 14 |
| » Lost to Angels (29-29), 10-4 | Comiskey Park I (14-17) | 26-29 | Lost 2 |
| » Starters: Dean Chance vs John Buzhardt | Sixth | 10½ out |
| Wednesday, June 15 |
| » Lost to Athletics (23-33), 5-4 | Comiskey Park I (14-18) | 26-30 | Lost 3 |
| » Starters: Lew Krausse vs Gary Peters | Sixth | 11½ out |
| Thursday, June 16 |
| » Defeated Athletics (23-34), 6-4 | Comiskey Park I (15-18) | 27-30 | |
| » Starters: Bill Stafford vs Bruce Howard | Fifth | 10 out |
| » Defeated Athletics (23-35), 5-2 | Comiskey Park I (16-18) | 28-30 | Won 2 |
| » Starters: Ralph Terry vs Juan Pizarro | Fifth | 10 out |
| Friday, June 17 |
| » Defeated Twins (28-31), 3-1 | Metropolitan Stadium (1-3) | 29-30 | Won 3 |
| » Starters: Tommy John vs Jim Perry | Fifth | 10 out |
| Future White Sox Shawn Abner is born in Hamilton, OH. |
| Saturday, June 18 |
| » Lost to Twins (29-31), 9-8 | Metropolitan Stadium (1-4) | 29-31 | |
| » Starters: Jack Lamabe vs Dave Boswell | Fifth | 11 out |
| Sunday, June 19 |
| » Lost to Twins (30-31), 6-4 | Metropolitan Stadium (1-5) | 29-32 | Lost 2 |
| » Starters: Gary Peters vs Jim Kaat | Sixth | 11½ out |
| Monday, June 20 |
| » Defeated Athletics (25-38), 3-1 | Municipal Stadium (2-1) | 30-32 | |
| » Starters: Joe Horlen vs Bill Stafford | Fifth | 11 out |
| Tuesday, June 21 |
| » Lost to Athletics (26-38), 9-8 | Municipal Stadium (2-2) | 30-33 | |
| » Starters: Tommy John vs Ralph Terry | Fifth | 11½ out |
| Wednesday, June 22 |
| » Defeated Athletics (26-39), 7-4 | Municipal Stadium (3-2) | 31-33 | |
| » Starters: Bruce Howard vs Catfish Hunter | Fifth | 12 out |
| » Lost to Athletics (27-39), 3-1 | Municipal Stadium (3-3) | 31-34 | |
| » Starters: John Buzhardt vs Chuck Dobson | Fifth | 12 out |
| Friday, June 24 |
| » Lost to Yankees (28-36), 5-2 | Yankee Stadium (1-2) | 31-35 | Lost 2 |
| » Starters: Juan Pizarro vs Jim Bouton | Fifth | 12½ out |
| Saturday, June 25 |
| » Defeated Yankees (28-37), 2-1 | Yankee Stadium (2-2) | 32-35 | |
| » Starters: Gary Peters vs Mel Stottlemyre | Fifth | 12½ out |
| Sunday, June 26 |
| » Lost to Yankees (29-37), 7-2 | Yankee Stadium (2-3) | 32-36 | |
| » Starters: Tommy John vs Fred Talbot | Sixth | 14 out |
| » Lost to Yankees (30-37), 2-0 | Yankee Stadium (2-4) | 32-37 | Lost 2 |
| » Starters: Joe Horlen vs Fritz Peterson | Sixth | 14 out |
| Tuesday, June 28 |
| » Lost to Senators (31-43), 4-1 | Comiskey Park I (16-19) | 32-38 | Lost 3 |
| » Starters: Mike McCormick vs Jack Lamabe | Sixth | 14½ out |
| Future White Sox Shawn Jeter is born in Shreveport, LA. |
| Wednesday, June 29 |
| » Defeated Senators (31-44), 5-0 | Comiskey Park I (17-19) | 33-38 | |
| » Starters: Pete Richert vs Bruce Howard | Sixth | 14½ out |
| Friday, July 1 |
| » Defeated Red Sox (27-48), 2-1 | Comiskey Park I (18-19) | 34-38 | Won 2 |
| » Starters: Bucky Brandon vs John Buzhardt | Fifth | 15½ out |
| Saturday, July 2 |
| » Defeated Red Sox (27-49), 6-0 | Comiskey Park I (19-19) | 35-38 | Won 3 |
| » Starters: Jose Santiago vs Joe Horlen | Fifth | 16 out |
| Sunday, July 3 |
| » Lost to Red Sox (28-49), 5-2 | Comiskey Park I (19-20) | 35-39 | |
| » Starters: Rollie Sheldon vs Jack Lamabe | Fifth | 16½ out |
| » Defeated Red Sox (28-50), 3-2 | Comiskey Park I (20-20) | 36-39 | |
| » Starters: Dick Stigman vs Tommy John | Fifth | 16½ out |
| Monday, July 4 |
| » Defeated Yankees (33-41), 5-0 | Yankee Stadium (3-4) | 37-39 | Won 2 |
| » Starters: Gary Peters vs Mel Stottlemyre | Fifth | 16 out |
| » Lost to Yankees (34-41), 5-2 | Yankee Stadium (3-5) | 37-40 | |
| » Starters: Juan Pizarro vs Fritz Peterson | Fifth | 16 out |
| Wednesday, July 6 |
| » Lost to Senators (34-47), 4-3 | Robert F. Kennedy Stadium (2-1) | 37-41 | Lost 2 |
| » Starters: John Buzhardt vs Phil Ortega | Sixth | 17 out |
| » Lost to Senators (35-47), 3-2 | Robert F. Kennedy Stadium (2-2) | 37-42 | Lost 3 |
| » Starters: Joe Horlen vs Mike McCormick | Sixth | 17 out |
| Former White Sox Sad Sam Jones dies in Barnesville, OH at the age of 74. |
| Thursday, July 7 |
| » Defeated Senators (35-48), 8-5 | Robert F. Kennedy Stadium (3-2) | 38-42 | |
| » Starters: Tommy John vs Pete Richert | Fifth | 16½ out |
| Future White Sox Jeff Shaw is born in Washington Court House, OH. |
| Friday, July 8 |
| » Lost to Red Sox (33-52), 3-1 | Fenway Park (1-1) | 38-43 | |
| » Starters: Jack Lamabe vs Jim Lonborg | Sixth | 18 out |
| » Lost to Red Sox (34-52), 5-1 | Fenway Park (1-2) | 38-44 | Lost 2 |
| » Starters: Bruce Howard vs Lee Stange | Sixth | 18 out |
| Saturday, July 9 |
| » Lost to Red Sox (35-52), 4-2 | Fenway Park (1-3) | 38-45 | Lost 3 |
| » Starters: Gary Peters vs Bucky Brandon | Sixth | 18½ out |
| Sunday, July 10 |
| » Lost to Red Sox (36-52), 8-4 | Fenway Park (1-4) | 38-46 | Lost 4 |
| » Starters: Joe Horlen vs Jose Santiago | Seventh | 19 out |
| » Lost to Red Sox (37-52), 10-6 | Fenway Park (1-5) | 38-47 | Lost 5 |
| » Starters: John Buzhardt vs Dave Morehead | Seventh | 19 out |
| Thursday, July 14 |
| » Defeated Indians (46-38), 2-1 | Comiskey Park I (21-20) | 39-47 | |
| » Starters: Gary Bell vs Tommy John | Sixth | 18 out |
| Friday, July 15 |
| » Defeated Indians (46-39), 4-2 | Comiskey Park I (22-20) | 40-47 | Won 2 |
| » Starters: Sonny Siebert vs Bruce Howard | Sixth | 17 out |
| Saturday, July 16 |
| » Defeated Indians (46-40), 7-2 | Comiskey Park I (23-20) | 41-47 | Won 3 |
| » Starters: Steve Hargan vs Joe Horlen | Sixth | 17 out |
| Sunday, July 17 |
| » Defeated Orioles (59-32), 5-1 | Comiskey Park I (24-20) | 42-47 | Won 4 |
| » Starters: Bill Short vs Gary Peters | Sixth | 17 out |
| » Lost to Orioles (60-32), 3-2 | Comiskey Park I (24-21) | 42-48 | |
| » Starters: Jim Palmer vs Jack Lamabe | Sixth | 17 out |
| Monday, July 18 |
| » Lost to Orioles (61-32), 5-3 | Comiskey Park I (24-22) | 42-49 | Lost 2 |
| » Starters: John Miller vs Juan Pizarro | Sixth | 18 out |
| Tuesday, July 19 |
| » Defeated Indians (49-41), 5-4 | Cleveland Stadium (2-1) | 43-49 | |
| » Starters: Bruce Howard vs Sonny Siebert | Sixth | 18 out |
| Wednesday, July 20 |
| » Defeated Indians (49-42), 6-3 | Cleveland Stadium (3-1) | 44-49 | Won 2 |
| » Starters: Joe Horlen vs Steve Hargan | Sixth | 18 out |
| Thursday, July 21 |
| » Defeated Indians (49-43), 7-2 | Cleveland Stadium (4-1) | 45-49 | Won 3 |
| » Starters: John Buzhardt vs Sonny Siebert | Sixth | 18 out |
| Friday, July 22 |
| » Lost to Orioles (65-32), 3-1 | Memorial Stadium (2-2) | 45-50 | |
| » Starters: Gary Peters vs Jim Palmer | Sixth | 19 out |
| Saturday, July 23 |
| » Lost to Orioles (66-32), 5-4 | Memorial Stadium (2-3) | 45-51 | Lost 2 |
| » Starters: Tommy John vs Bill Short | Sixth | 20 out |
| Sunday, July 24 |
| » Defeated Orioles (66-33), 4-0 | Memorial Stadium (3-3) | 46-51 | |
| » Starters: Bruce Howard vs Eddie Watt | Sixth | 19 out |
| Tuesday, July 26 |
| » Lost to Tigers (53-43), 3-1 | Comiskey Park I (24-23) | 46-52 | |
| » Starters: Mickey Lolich vs Joe Horlen | Sixth | 19 out |
| Wednesday, July 27 |
| » Defeated Tigers (53-44), 5-0 | Comiskey Park I (25-23) | 47-52 | |
| » Starters: Earl Wilson vs John Buzhardt | Sixth | 19 out |
| Thursday, July 28 |
| » Defeated Tigers (53-45), 2-1 | Comiskey Park I (26-23) | 48-52 | Won 2 |
| » Starters: Denny McLain vs Jack Lamabe | Sixth | 18½ out |
| Friday, July 29 |
| » Lost to Yankees (47-52), 2-1 | Comiskey Park I (26-24) | 48-53 | |
| » Starters: Al Downing vs Bruce Howard | Seventh | 19½ out |
| Saturday, July 30 |
| » Defeated Yankees (47-53), 6-0 | Comiskey Park I (27-24) | 49-53 | |
| » Starters: Mel Stottlemyre vs Gary Peters | Sixth | 18½ out |
| Sunday, July 31 |
| » Defeated Yankees (47-54), 4-1 | Comiskey Park I (28-24) | 50-53 | Won 2 |
| » Starters: Fritz Peterson vs Joe Horlen | Sixth | 18 out |
| » Defeated Yankees (47-55), 5-0 | Comiskey Park I (29-24) | 51-53 | Won 3 |
| » Starters: Steve Hamilton vs Tommy John | Sixth | 18 out |
| Tuesday, August 2 |
| » Lost to Tigers (56-47), 5-0 | Tiger Stadium (1-3) | 51-54 | |
| » Starters: John Buzhardt vs Denny McLain | Sixth | 19 out |
| Wednesday, August 3 |
| » Lost to Tigers (57-47), 3-1 | Tiger Stadium (1-4) | 51-55 | Lost 2 |
| » Starters: Bruce Howard vs Mickey Lolich | Sixth | 18½ out |
| » Defeated Tigers (57-48), 6-3 | Tiger Stadium (2-4) | 52-55 | |
| » Starters: Jack Lamabe vs Johnny Podres | Sixth | 18½ out |
| Friday, August 5 |
| » Defeated Angels (57-51), 3-1 | Anaheim Stadium (4-3) | 53-55 | Won 2 |
| » Starters: Gary Peters vs Clyde Wright | Sixth | 17 out |
| Saturday, August 6 |
| » Defeated Angels (57-52), 7-1 | Anaheim Stadium (5-3) | 54-55 | Won 3 |
| » Starters: Tommy John vs George Brunet | Sixth | 17 out |
| Sunday, August 7 |
| » Defeated Angels (57-53), 9-8 | Anaheim Stadium (6-3) | 55-55 | Won 4 |
| » Starters: Joe Horlen vs Dean Chance | Sixth | 16 out |
| Tuesday, August 9 |
| » Defeated Athletics (50-62), 2-1 | Municipal Stadium (4-3) | 56-55 | Won 5 |
| » Starters: Bruce Howard vs Gil Blanco | Fifth | 15 out |
| Wednesday, August 10 |
| » Defeated Athletics (50-63), 9-2 | Municipal Stadium (5-3) | 57-55 | Won 6 |
| » Starters: Gary Peters vs Lew Krausse | Sixth | 15 out |
| Thursday, August 11 |
| » Defeated Athletics (50-64), 10-9 | Municipal Stadium (6-3) | 58-55 | Won 7 |
| » Starters: John Buzhardt vs Blue Moon Odom | Fifth | 15 out |
| Friday, August 12 |
| » Defeated Angels (58-56), 1-0 | Comiskey Park I (30-24) | 59-55 | Won 8 |
| » Starters: Dean Chance vs Tommy John | Fourth | 14½ out |
| Saturday, August 13 |
| » Lost to Angels (59-56), 7-3 | Comiskey Park I (30-25) | 59-56 | |
| » Starters: Fred Newman vs Joe Horlen | Fifth | 15½ out |
| Sunday, August 14 |
| » Defeated Angels (59-57), 4-0 | Comiskey Park I (31-25) | 60-56 | |
| » Starters: Marcelino Lopez vs Gary Peters | Fourth | 16 out |
| » Lost to Angels (60-57), 4-0 | Comiskey Park I (31-26) | 60-57 | |
| » Starters: Jim Coates vs Bruce Howard | Fourth | 16 out |
| Monday, August 15 |
| » Defeated Athletics (52-66), 4-3 | Comiskey Park I (32-26) | 61-57 | |
| » Starters: Lew Krausse vs Joe Horlen | Fourth | 16 out |
| Tuesday, August 16 |
| » Lost to Athletics (53-66), 4-2 | Comiskey Park I (32-27) | 61-58 | |
| » Starters: Blue Moon Odom vs Tommy John | Fifth | 17 out |
| Wednesday, August 17 |
| » Defeated Athletics (53-67), 4-2 | Comiskey Park I (33-27) | 62-58 | |
| » Starters: Paul Lindblad vs John Buzhardt | Fourth | 16½ out |
| » Defeated Athletics (53-68), 5-1 | Comiskey Park I (34-27) | 63-58 | Won 2 |
| » Starters: Vern Handrahan vs Jack Lamabe | Fourth | 16½ out |
| Thursday, August 18 |
| » Lost to Indians (65-57), 2-0 | Cleveland Stadium (4-2) | 63-59 | |
| » Starters: Gary Peters vs Sam McDowell | Fifth | 17 out |
| Future White Sox Bob Zupcic is born in Pittsburgh, PA. |
| Friday, August 19 |
| » Lost to Indians (66-57), 3-2 | Cleveland Stadium (4-3) | 63-60 | Lost 2 |
| » Starters: Joe Horlen vs Sonny Siebert | Fifth | 17 out |
| Saturday, August 20 |
| » Defeated Indians (66-58), 4-1 | Cleveland Stadium (5-3) | 64-60 | |
| » Starters: Tommy John vs Gary Bell | Fourth | 17 out |
| Sunday, August 21 |
| » Defeated Indians (66-59), 3-2 | Cleveland Stadium (6-3) | 65-60 | Won 2 |
| » Starters: John Buzhardt vs Steve Hargan | Fourth | 16 out |
| Tuesday, August 23 |
| » Defeated Tigers (67-56), 2-1 | Tiger Stadium (3-4) | 66-60 | Won 3 |
| » Starters: Gary Peters vs Johnny Podres | Fifth | 15 out |
| Wednesday, August 24 |
| » Lost to Tigers (68-56), 6-2 | Tiger Stadium (3-5) | 66-61 | |
| » Starters: Tommy John vs Mickey Lolich | Fifth | 15 out |
| Thursday, August 25 |
| » Lost to Tigers (69-56), 8-0 | Tiger Stadium (3-6) | 66-62 | Lost 2 |
| » Starters: Joe Horlen vs Denny McLain | Fifth | 16 out |
| Future White Sox Albert Belle is born in Shreveport, LA. |
| Friday, August 26 |
| » Lost to Twins (68-61), 7-4 | Comiskey Park I (34-28) | 66-63 | Lost 3 |
| » Starters: Jim Merritt vs John Buzhardt | Fourth | 17 out |
| Saturday, August 27 |
| » Lost to Twins (69-61), 1-0 | Comiskey Park I (34-29) | 66-64 | Lost 4 |
| » Starters: Jim Kaat vs Gary Peters | Sixth | 17 out |
| Sunday, August 28 |
| » Defeated Twins (69-62), 4-3 | Comiskey Park I (35-29) | 67-64 | |
| » Starters: Mudcat Grant vs Bruce Howard | Fifth | 15½ out |
| » Defeated Twins (69-63), 7-6 | Comiskey Park I (36-29) | 68-64 | Won 2 |
| » Starters: Dwight Siebler vs Jack Lamabe | Fifth | 15½ out |
| Monday, August 29 |
| » Defeated Indians (68-64), 2-0 | Comiskey Park I (37-29) | 69-64 | Won 3 |
| » Starters: Gary Bell vs Tommy John | Fourth | 14½ out |
| Former White Sox Al DeVormer dies in Grand Rapids, MI at the age of 76. |
| Tuesday, August 30 |
| » Lost to Indians (69-64), 6-2 | Comiskey Park I (37-30) | 69-65 | |
| » Starters: Steve Hargan vs John Buzhardt | Fifth | 14½ out |
| Wednesday, August 31 |
| » Defeated Tigers (71-60), 7-6 | Comiskey Park I (38-30) | 70-65 | |
| » Starters: Hank Aguirre vs Dennis Higgins | Fourth | 14 out |
| » Defeated Tigers (71-61), 3-1 | Comiskey Park I (39-30) | 71-65 | Won 2 |
| » Starters: Johnny Podres vs Gary Peters | Fourth | 14 out |
| Thursday, September 1 |
| » Lost to Tigers (72-61), 7-5 | Comiskey Park I (39-31) | 71-66 | |
| » Starters: Mickey Lolich vs Bruce Howard | Fifth | 14 out |
| Friday, September 2 |
| » Defeated Orioles (83-51), 9-8 | Comiskey Park I (40-31) | 72-66 | |
| » Starters: Dave McNally vs Tommy John | Fourth | 13 out |
| Saturday, September 3 |
| » Lost to Orioles (84-51), 4-1 | Comiskey Park I (40-32) | 72-67 | |
| » Starters: Wally Bunker vs Jack Lamabe | Fourth | 14 out |
| Sunday, September 4 |
| » Lost to Orioles (85-51), 8-5 | Comiskey Park I (40-33) | 72-68 | Lost 2 |
| » Starters: Eddie Watt vs Gary Peters | Fourth | 15 out |
| Monday, September 5 |
| » Defeated Twins (75-65), 7-4 | Metropolitan Stadium (2-5) | 73-68 | |
| » Starters: Bruce Howard vs Camilo Pascual | Fourth | 15½ out |
| Tuesday, September 6 |
| » Lost to Twins (76-65), 4-3 | Metropolitan Stadium (2-6) | 73-69 | |
| » Starters: Tommy John vs Mudcat Grant | Fourth | 16½ out |
| Wednesday, September 7 |
| » Lost to Twins (77-65), 6-4 | Metropolitan Stadium (2-7) | 73-70 | Lost 2 |
| » Starters: Jack Lamabe vs Jim Perry | Fourth | 17½ out |
| Friday, September 9 |
| » Defeated Senators (64-82), 1-0 | Comiskey Park I (41-33) | 74-70 | |
| » Starters: Pete Richert vs Gary Peters | Fourth | 16½ out |
| » Major-league debuts: Buddy Bradford (White Sox) Hank Allen (Senators) |
| Saturday, September 10 |
| » Defeated Senators (64-83), 1-0 | Comiskey Park I (42-33) | 75-70 | Won 2 |
| » Starters: Mike McCormick vs Bruce Howard | Fourth | 15½ out |
| Sunday, September 11 |
| » Defeated Senators (64-84), 4-1 | Comiskey Park I (43-33) | 76-70 | Won 3 |
| » Starters: Jim Hannan vs Fred Klages | Fourth | 14½ out |
| » Major-league debuts: Ed Stroud (White Sox) |
| Tuesday, September 13 |
| » Lost to Red Sox (65-85), 10-1 | Fenway Park (1-6) | 76-71 | |
| » Starters: Tommy John vs Jim Lonborg | Fourth | 14½ out |
| Wednesday, September 14 |
| » Lost to Red Sox (66-85), 2-1 | Fenway Park (1-7) | 76-72 | Lost 2 |
| » Starters: Bruce Howard vs Hank Fischer | Fourth | 15 out |
| Thursday, September 15 |
| » Lost to Red Sox (67-85), 5-4 | Fenway Park (1-8) | 76-73 | Lost 3 |
| » Starters: Jack Lamabe vs Bucky Brandon | Fourth | 16½ out |
| Friday, September 16 |
| » Defeated Orioles (91-56), 4-0 | Memorial Stadium (4-3) | 77-73 | |
| » Starters: Joe Horlen vs Dave McNally | Fourth | 15½ out |
| » Major-league debuts: Mike Epstein (Orioles) |
| Saturday, September 17 |
| » Defeated Orioles (91-57), 3-1 | Memorial Stadium (5-3) | 78-73 | Won 2 |
| » Starters: Tommy John vs Jim Palmer | Fourth | 14½ out |
| Sunday, September 18 |
| » Defeated Orioles (91-58), 4-3 | Memorial Stadium (6-3) | 79-73 | Won 3 |
| » Starters: Bruce Howard vs Wally Bunker | Fourth | 13½ out |
| Thursday, September 22 |
| » Defeated Yankees (66-87), 4-1 |
