| Tuesday, January 25 |
| Future Tiger Richie Lewis is born in Muncie, IN. |
| Monday, February 14 |
| Former Tiger Jack Coffey dies in Bronx, NY at the age of 80. |
| Friday, February 18 |
| Former Tiger Marty McManus dies in St.Louis, MO at the age of 66. |
| Sunday, March 6 |
| Future Tiger Joe Hall is born in Paducah, KY. |
| Wednesday, March 9 |
| Former Tiger Aaron Robinson dies in Lancaster, SC at the age of 51. |
| Friday, March 25 |
| Former Tiger Bill Morrisette dies in Virginia Beach, VA at the age of 74. |
| Tuesday, April 12 |
| » Defeated Yankees (0-1), 2-1 | Yankee Stadium (1-0) | 1-0 | |
| » Starters: Mickey Lolich vs Whitey Ford | First | -- |
| Thursday, April 14 |
| » Defeated Yankees (0-2), 3-2 | Yankee Stadium (2-0) | 2-0 | Won 2 |
| » Starters: Denny McLain vs Mel Stottlemyre | First | -- |
| » Defeated Yankees (0-3), 5-2 | Yankee Stadium (3-0) | 3-0 | Won 3 |
| » Starters: Bill Monbouquette vs Bob Friend | First | -- |
| » Major-league debuts: Dooley Womack (Yankees) |
| Friday, April 15 |
| » Defeated Senators (0-2), 8-3 | Tiger Stadium (1-0) | 4-0 | Won 4 |
| » Starters: Jim Duckworth vs Dave Wickersham | First | -- |
| » Major-league debuts: Casey Cox (Senators) |
| Saturday, April 16 |
| » Defeated Senators (0-3), 7-5 | Tiger Stadium (2-0) | 5-0 | Won 5 |
| » Starters: Pete Richert vs Mickey Lolich | First | -- |
| » Major-league debuts: Dick Lines (Senators) |
| Sunday, April 17 |
| » Lost to Senators (1-3), 10-4 | Tiger Stadium (2-1) | 5-1 | |
| » Starters: Mike McCormick vs Hank Aguirre | Second | 1 out |
| Tuesday, April 19 |
| » Lost to Red Sox (1-5), 7-0 | Fenway Park (0-1) | 5-2 | Lost 2 |
| » Starters: Bill Monbouquette vs Dave Morehead | Fourth | 1½ out |
| » Defeated Red Sox (1-6), 6-4 | Fenway Park (1-1) | 6-2 | |
| » Starters: Denny McLain vs Jim Lonborg | Fourth | 1½ out |
| » Major-league debuts: Darrell Brandon (Red Sox) |
| Wednesday, April 20 |
| » Lost to Red Sox (2-6), 5-3 | Fenway Park (1-2) | 6-3 | |
| » Starters: Dave Wickersham vs Jerry Stephenson | Third | 1½ out |
| Thursday, April 21 |
| » Major-league debuts: Jorge Rubio (Angels) |
| Saturday, April 23 |
| » Lost to Senators (2-5), 5-3 | Robert F. Kennedy Stadium (0-1) | 6-4 | Lost 2 |
| » Starters: Mickey Lolich vs Mike McCormick | Fifth | 2½ out |
| Sunday, April 24 |
| » Defeated Senators (2-6), 4-0 | Robert F. Kennedy Stadium (1-1) | 7-4 | |
| » Starters: Bill Monbouquette vs Pete Richert | Third | 2½ out |
| » Defeated Senators (2-7), 4-1 | Robert F. Kennedy Stadium (2-1) | 8-4 | Won 2 |
| » Starters: Joe Sparma vs Jim Duckworth | Third | 2½ out |
| Monday, April 25 |
| » Defeated Twins (4-6), 3-0 | Tiger Stadium (3-1) | 9-4 | Won 3 |
| » Starters: Dave Boswell vs Denny McLain | Fourth | 2½ out |
| Thursday, April 28 |
| » Defeated Athletics (2-9), 13-5 | Tiger Stadium (4-1) | 10-4 | Won 4 |
| » Starters: Catfish Hunter vs Mickey Lolich | Fourth | 2 out |
| Future Tiger Jim Poole is born in Rochester, NY. |
| Friday, April 29 |
| » Lost to Orioles (10-1), 8-1 | Tiger Stadium (4-2) | 10-5 | |
| » Starters: Wally Bunker vs Bill Monbouquette | Third | 2 out |
| Saturday, April 30 |
| » Lost to Orioles (11-1), 3-2 | Tiger Stadium (4-3) | 10-6 | Lost 2 |
| » Starters: Dave McNally vs Denny McLain | Fourth | 3 out |
| Sunday, May 1 |
| » Lost to Orioles (12-1), 4-1 | Tiger Stadium (4-4) | 10-7 | Lost 3 |
| » Starters: Steve Barber vs Joe Sparma | Fourth | 4 out |
| Tuesday, May 3 |
| » Defeated Red Sox (4-12), 8-0 | Tiger Stadium (5-4) | 11-7 | |
| » Starters: Jose Santiago vs Mickey Lolich | Fourth | 3½ out |
| Wednesday, May 4 |
| » Lost to Red Sox (5-12), 7-0 | Tiger Stadium (5-5) | 11-8 | |
| » Starters: Earl Wilson vs Bill Monbouquette | Fifth | 4½ out |
| Friday, May 6 |
| » Defeated White Sox (10-7), 1-0 | Comiskey Park I (1-0) | 12-8 | |
| » Starters: Denny McLain vs Gary Peters | Fourth | 4 out |
| Saturday, May 7 |
| » Lost to White Sox (11-7), 1-0 | Comiskey Park I (1-1) | 12-9 | |
| » Starters: Joe Sparma vs Tommy John | Fifth | 5 out |
| Sunday, May 8 |
| » Defeated White Sox (11-8), 3-1 | Comiskey Park I (2-1) | 13-9 | |
| » Starters: Hank Aguirre vs Joe Horlen | Second | 3½ out |
| Tuesday, May 10 |
| » Defeated Indians (15-5), 3-2 | Cleveland Stadium (1-0) | 14-9 | Won 2 |
| » Starters: Mickey Lolich vs Gary Bell | Third | 3½ out |
| Friday, May 13 |
| » Defeated White Sox (13-10), 5-4 | Tiger Stadium (6-5) | 15-9 | Won 3 |
| » Starters: Joe Horlen vs Denny McLain | Third | 2½ out |
| Saturday, May 14 |
| » Lost to White Sox (14-10), 13-3 | Tiger Stadium (6-6) | 15-10 | |
| » Starters: Gary Peters vs Mickey Lolich | Third | 3½ out |
| Sunday, May 15 |
| » Defeated White Sox (14-11), 8-6 | Tiger Stadium (7-6) | 16-10 | |
| » Starters: Tommy John vs Hank Aguirre | Third | 3 out |
| Tuesday, May 17 |
| » Defeated Yankees (10-19), 7-2 | Tiger Stadium (8-6) | 17-10 | Won 2 |
| » Manager: Bob Swift |
| » Starters: Fritz Peterson vs Denny McLain | Third | 3 out |
| Wednesday, May 18 |
| » Lost to Yankees (11-19), 7-2 | Tiger Stadium (8-7) | 17-11 | |
| » Starters: Mel Stottlemyre vs Mickey Lolich | Third | 3 out |
| Friday, May 20 |
| » Lost to Orioles (19-11), 8-4 | Memorial Stadium (0-1) | 17-12 | Lost 2 |
| » Starters: Joe Sparma vs Wally Bunker | Third | 3 out |
| » Defeated Orioles (19-12), 9-5 | Memorial Stadium (1-1) | 18-12 | |
| » Starters: Bill Monbouquette vs Dave McNally | Third | 3 out |
| Saturday, May 21 |
| » Defeated Orioles (19-13), 7-5 | Memorial Stadium (2-1) | 19-12 | Won 2 |
| » Starters: Denny McLain vs John Miller | Second | 2 out |
| Sunday, May 22 |
| » Defeated Orioles (19-14), 3-2 | Memorial Stadium (3-1) | 20-12 | Won 3 |
| » Starters: Mickey Lolich vs Frank Bertaina | Second | 2½ out |
| Tuesday, May 24 |
| » Defeated Indians (22-10), 7-6 | Tiger Stadium (9-7) | 21-12 | Won 4 |
| » Starters: Gary Bell vs Joe Sparma | Second | 2½ out |
| » Lost to Indians (23-10), 2-0 | Tiger Stadium (9-8) | 21-13 | |
| » Starters: Luis Tiant vs Hank Aguirre | Second | 2½ out |
| Wednesday, May 25 |
| » Lost to Indians (24-10), 13-2 | Tiger Stadium (9-9) | 21-14 | Lost 2 |
| » Starters: Sam McDowell vs Denny McLain | Second | 3½ out |
| Future Tiger Bill Haselman is born in Long Branch, NJ. |
| Thursday, May 26 |
| » Lost to Indians (25-10), 8-4 | Tiger Stadium (9-10) | 21-15 | Lost 3 |
| » Starters: Sonny Siebert vs Mickey Lolich | Second | 4½ out |
| Friday, May 27 |
| » Lost to Angels (20-18), 3-2 | Tiger Stadium (9-11) | 21-16 | Lost 4 |
| » Starters: Marcelino Lopez vs Bill Monbouquette | Third | 5½ out |
| Saturday, May 28 |
| » Defeated Angels (20-19), 5-4 | Tiger Stadium (10-11) | 22-16 | |
| » Starters: Fred Newman vs Dave Wickersham | Third | 5½ out |
| Sunday, May 29 |
| » Lost to Angels (21-19), 2-1 | Tiger Stadium (10-12) | 22-17 | |
| » Starters: George Brunet vs Hank Aguirre | Third | 5 out |
| Monday, May 30 |
| » Defeated Athletics (14-25), 5-2 | Municipal Stadium (1-0) | 23-17 | |
| » Starters: Denny McLain vs Chuck Dobson | Third | 3½ out |
| Tuesday, May 31 |
| » Lost to Athletics (15-25), 7-1 | Municipal Stadium (1-1) | 23-18 | |
| » Starters: Bill Monbouquette vs Fred Talbot | Third | 4½ out |
| Wednesday, June 1 |
| » Defeated Twins (20-22), 9-4 | Metropolitan Stadium (1-0) | 24-18 | |
| » Starters: Dave Wickersham vs Dave Boswell | Third | 3½ out |
| Thursday, June 2 |
| » Defeated Twins (20-23), 7-6 | Metropolitan Stadium (2-0) | 25-18 | Won 2 |
| » Starters: Mickey Lolich vs Jim Kaat | Third | 2½ out |
| Friday, June 3 |
| » Defeated Angels (23-23), 1-0 | Anaheim Stadium (1-0) | 26-18 | Won 3 |
| » Starters: Hank Aguirre vs Marcelino Lopez | Third | 2½ out |
| Saturday, June 4 |
| » Lost to Angels (24-23), 4-1 | Anaheim Stadium (1-1) | 26-19 | |
| » Starters: Denny McLain vs George Brunet | Third | 3½ out |
| Sunday, June 5 |
| » Defeated Angels (24-24), 8-4 | Anaheim Stadium (2-1) | 27-19 | |
| » Starters: Bill Monbouquette vs Dean Chance | Third | 2 out |
| » Defeated Angels (24-25), 4-1 | Anaheim Stadium (3-1) | 28-19 | Won 2 |
| » Starters: Joe Sparma vs Howie Reed | Third | 2 out |
| Tuesday, June 7 |
| » Defeated Red Sox (19-31), 2-1 | Tiger Stadium (11-12) | 29-19 | Won 3 |
| » Starters: Bob Sadowski vs Mickey Lolich | Third | 1 out |
| Wednesday, June 8 |
| » Defeated Red Sox (19-32), 5-4 | Tiger Stadium (12-12) | 30-19 | Won 4 |
| » Starters: Earl Wilson vs Denny McLain | Third | 1½ out |
| Thursday, June 9 |
| » Defeated Red Sox (19-33), 9-1 | Tiger Stadium (13-12) | 31-19 | Won 5 |
| » Starters: Jose Santiago vs Dave Wickersham | Third | 1½ out |
| Friday, June 10 |
| » Defeated Yankees (22-27), 6-2 | Tiger Stadium (14-12) | 32-19 | Won 6 |
| » Starters: Jim Bouton vs Hank Aguirre | Third | 1½ out |
| Saturday, June 11 |
| » Lost to Yankees (23-27), 6-3 | Tiger Stadium (14-13) | 32-20 | |
| » Starters: Fritz Peterson vs Joe Sparma | Third | 1½ out |
| Sunday, June 12 |
| » Defeated Yankees (23-28), 7-5 | Tiger Stadium (15-13) | 33-20 | |
| » Starters: Mel Stottlemyre vs Denny McLain | Third | 2 out |
| » Lost to Yankees (24-28), 12-10 | Tiger Stadium (15-14) | 33-21 | |
| » Starters: Fred Talbot vs Mickey Lolich | Third | 2 out |
| Monday, June 13 |
| » Defeated Senators (23-36), 4-3 | Tiger Stadium (16-14) | 34-21 | |
| » Starters: Diego Segui vs Dave Wickersham | Third | 1½ out |
| Tuesday, June 14 |
| » Lost to Senators (24-36), 3-2 | Tiger Stadium (16-15) | 34-22 | |
| » Starters: Phil Ortega vs Bill Monbouquette | Third | 3 out |
| Wednesday, June 15 |
| » Defeated Red Sox (21-37), 11-7 | Fenway Park (2-2) | 35-22 | |
| » Starters: Joe Sparma vs Jim Lonborg | Third | 3 out |
| Thursday, June 16 |
| » Defeated Red Sox (21-38), 16-4 | Fenway Park (3-2) | 36-22 | Won 2 |
| » Starters: Denny McLain vs Rollie Sheldon | Third | 2 out |
| Friday, June 17 |
| » Lost to Yankees (26-31), 5-2 | Yankee Stadium (3-1) | 36-23 | |
| » Starters: Earl Wilson vs Mel Stottlemyre | Third | 3 out |
| Saturday, June 18 |
| » Defeated Yankees (26-32), 4-3 | Yankee Stadium (4-1) | 37-23 | |
| » Starters: Hank Aguirre vs Al Downing | Third | 3 out |
| Sunday, June 19 |
| » Defeated Yankees (26-33), 2-1 | Yankee Stadium (5-1) | 38-23 | Won 2 |
| » Starters: Dave Wickersham vs Jim Bouton | Third | 2½ out |
| Tuesday, June 21 |
| » Defeated Senators (28-39), 5-2 | Robert F. Kennedy Stadium (3-1) | 39-23 | Won 3 |
| » Starters: Denny McLain vs Diego Segui | Second | 2 out |
| Wednesday, June 22 |
| » Defeated Senators (28-40), 12-2 | Robert F. Kennedy Stadium (4-1) | 40-23 | Won 4 |
| » Starters: Mickey Lolich vs Phil Ortega | Second | 2 out |
| Thursday, June 23 |
| » Defeated Senators (28-41), 6-1 | Robert F. Kennedy Stadium (5-1) | 41-23 | Won 5 |
| » Starters: Earl Wilson vs Mike McCormick | Second | 2 out |
| Friday, June 24 |
| » Defeated Twins (30-35), 2-1 | Tiger Stadium (17-15) | 42-23 | Won 6 |
| » Starters: Jim Kaat vs Dave Wickersham | Second | 1½ out |
| » Lost to Twins (31-35), 9-2 | Tiger Stadium (17-16) | 42-24 | |
| » Starters: Camilo Pascual vs Hank Aguirre | Second | 1½ out |
| Saturday, June 25 |
| » Defeated Twins (31-36), 1-0 | Tiger Stadium (18-16) | 43-24 | |
| » Starters: Mudcat Grant vs Denny McLain | Second | 1½ out |
| Sunday, June 26 |
| » Lost to Twins (32-36), 7-5 | Tiger Stadium (18-17) | 43-25 | |
| » Starters: Dave Boswell vs Joe Sparma | Second | 3 out |
| » Lost to Twins (33-36), 7-1 | Tiger Stadium (18-18) | 43-26 | Lost 2 |
| » Starters: Jim Perry vs Mickey Lolich | Second | 3 out |
| Former Tiger Lil Stoner dies in Enid, OK at the age of 68. |
| Tuesday, June 28 |
| » Defeated Angels (38-35), 15-3 | Anaheim Stadium (4-1) | 44-26 | |
| » Starters: Earl Wilson vs Clyde Wright | Second | 2½ out |
| Wednesday, June 29 |
| » Lost to Angels (39-35), 6-2 | Anaheim Stadium (4-2) | 44-27 | |
| » Starters: Dave Wickersham vs George Brunet | Second | 3½ out |
| Friday, July 1 |
| » Defeated Athletics (31-43), 8-5 | Tiger Stadium (19-18) | 45-27 | |
| » Starters: Bill Stafford vs Denny McLain | Second | 5 out |
| » Lost to Athletics (32-43), 6-4 | Tiger Stadium (19-19) | 45-28 | |
| » Starters: Catfish Hunter vs Mickey Lolich | Second | 5 out |
| Saturday, July 2 |
| » Defeated Athletics (32-44), 7-3 | Tiger Stadium (20-19) | 46-28 | |
| » Starters: Paul Lindblad vs Earl Wilson | Second | 5½ out |
| Sunday, July 3 |
| » Lost to Athletics (33-44), 3-0 | Tiger Stadium (20-20) | 46-29 | |
| » Starters: Lew Krausse vs Dave Wickersham | Second | 7 out |
| » Lost to Athletics (34-44), 10-4 | Tiger Stadium (20-21) | 46-30 | Lost 2 |
| » Starters: Jim Nash vs Hank Aguirre | Second | 7 out |
| Monday, July 4 |
| » Lost to Angels (42-37), 11-6 | Tiger Stadium (20-22) | 46-31 | Lost 3 |
| » Starters: Jim McGlothlin vs Mickey Lolich | Second | 7 out |
| Tuesday, July 5 |
| » Lost to Angels (43-37), 4-3 | Tiger Stadium (20-23) | 46-32 | Lost 4 |
| » Starters: Dean Chance vs Denny McLain | Second | 7½ out |
| Former Tiger Pete Fox dies in Detroit, MI at the age of 58. |
| Wednesday, July 6 |
| » Lost to Angels (44-37), 1-0 | Tiger Stadium (20-24) | 46-33 | Lost 5 |
| » Starters: George Brunet vs Earl Wilson | Second | 8 out |
| Thursday, July 7 |
| » Defeated Twins (38-44), 4-3 | Metropolitan Stadium (3-0) | 47-33 | |
| » Starters: Dave Wickersham vs Mudcat Grant | Second | 7½ out |
| Friday, July 8 |
| » Lost to Twins (39-44), 6-1 | Metropolitan Stadium (3-1) | 47-34 | |
| » Starters: Mickey Lolich vs Jim Kaat | Second | 8½ out |
| Saturday, July 9 |
| » Defeated Twins (39-45), 8-1 | Metropolitan Stadium (4-1) | 48-34 | |
| » Starters: Denny McLain vs Jim Merritt | Second | 8 out |
| Sunday, July 10 |
| » Lost to Twins (40-45), 4-2 | Metropolitan Stadium (4-2) | 48-35 | |
| » Starters: Earl Wilson vs Dave Boswell | Second | 8 out |
| Thursday, July 14 |
| » Defeated Orioles (58-30), 4-3 | Tiger Stadium (21-24) | 49-35 | |
| » Manager: Frank Skaff |
| » Starters: Steve Barber vs Earl Wilson | Second | 7 out |
| Friday, July 15 |
| » Defeated Orioles (58-31), 8-5 | Tiger Stadium (22-24) | 50-35 | Won 2 |
| » Starters: Wally Bunker vs Dave Wickersham | Second | 6 out |
| Saturday, July 16 |
| » Lost to Orioles (59-31), 8-2 | Tiger Stadium (22-25) | 50-36 | |
| » Starters: Dave McNally vs Denny McLain | Second | 7 out |
| Sunday, July 17 |
| » Lost to Indians (47-40), 7-3 | Tiger Stadium (22-26) | 50-37 | Lost 2 |
| » Starters: Tom Kelley vs Hank Aguirre | Second | 8 out |
| » Lost to Indians (48-40), 15-2 | Tiger Stadium (22-27) | 50-38 | Lost 3 |
| » Starters: John O'Donoghue vs Joe Sparma | Second | 8 out |
| Tuesday, July 19 |
| » Lost to Orioles (62-32), 13-3 | Memorial Stadium (3-2) | 50-39 | Lost 4 |
| » Starters: Earl Wilson vs Eddie Watt | Second | 9½ out |
| Wednesday, July 20 |
| » Lost to Orioles (63-32), 10-7 | Memorial Stadium (3-3) | 50-40 | Lost 5 |
| » Starters: Denny McLain vs Wally Bunker | Second | 10½ out |
| Thursday, July 21 |
| » Lost to Orioles (64-32), 6-4 | Memorial Stadium (3-4) | 50-41 | Lost 6 |
| » Starters: Bill Monbouquette vs Dave McNally | Second | 11½ out |
| Friday, July 22 |
| » Defeated Indians (49-44), 10-5 | Cleveland Stadium (2-0) | 51-41 | |
| » Starters: Mickey Lolich vs Gary Bell | Second | 11½ out |
| Saturday, July 23 |
| » Lost to Indians (50-44), 6-5 | Cleveland Stadium (2-1) | 51-42 | |
| » Starters: Joe Sparma vs John O'Donoghue | Second | 12½ out |
| Sunday, July 24 |
| » Lost to Indians (51-44), 3-0 | Cleveland Stadium (2-2) | 51-43 | Lost 2 |
| » Starters: Denny McLain vs Steve Hargan | Second | 12 out |
| » Defeated Indians (51-45), 2-1 | Cleveland Stadium (3-2) | 52-43 | |
| » Starters: Johnny Podres vs Tom Kelley | Second | 12 out |
| Tuesday, July 26 |
| » Defeated White Sox (46-52), 3-1 | Comiskey Park I (3-1) | 53-43 | Won 2 |
| » Starters: Mickey Lolich vs Joe Horlen | Second | 11 out |
| Wednesday, July 27 |
| » Lost to White Sox (47-52), 5-0 | Comiskey Park I (3-2) | 53-44 | |
| » Starters: Earl Wilson vs John Buzhardt | Second | 12 out |
| Thursday, July 28 |
| » Lost to White Sox (48-52), 2-1 | Comiskey Park I (3-3) | 53-45 | Lost 2 |
| » Starters: Denny McLain vs Jack Lamabe | Second | 12½ out |
| Friday, July 29 |
| » Lost to Athletics (44-55), 4-1 | Municipal Stadium (1-2) | 53-46 | Lost 3 |
| » Starters: Johnny Podres vs Lew Krausse | Second | 13½ out |
| Saturday, July 30 |
| » Lost to Athletics (45-55), 2-1 | Municipal Stadium (1-3) | 53-47 | Lost 4 |
| » Starters: Mickey Lolich vs Blue Moon Odom | Second | 13½ out |
| Sunday, July 31 |
| » Defeated Athletics (45-56), 5-4 | Municipal Stadium (2-3) | 54-47 | |
| » Starters: Bill Monbouquette vs Jim Nash | Second | 13 out |
| » Defeated Athletics (45-57), 7-1 | Municipal Stadium (3-3) | 55-47 | Won 2 |
| » Starters: Earl Wilson vs Gil Blanco | Second | 13 out |
| Tuesday, August 2 |
| » Defeated White Sox (51-54), 5-0 | Tiger Stadium (23-27) | 56-47 | Won 3 |
| » Starters: John Buzhardt vs Denny McLain | Second | 13 out |
| Wednesday, August 3 |
| » Defeated White Sox (51-55), 3-1 | Tiger Stadium (24-27) | 57-47 | Won 4 |
| » Starters: Bruce Howard vs Mickey Lolich | Second | 12½ out |
| » Lost to White Sox (52-55), 6-3 | Tiger Stadium (24-28) | 57-48 | |
| » Starters: Jack Lamabe vs Johnny Podres | Second | 12½ out |
| Thursday, August 4 |
| Former Tiger Pug Cavet dies in San Luis Obispo, CA at the age of 77. |
| Friday, August 5 |
| » Defeated Red Sox (45-66), 2-0 | Tiger Stadium (25-28) | 58-48 | |
| » Starters: Dennis Bennett vs Earl Wilson | Second | 11 out |
| Saturday, August 6 |
| » Lost to Red Sox (46-66), 8-2 | Tiger Stadium (25-29) | 58-49 | |
| » Starters: Lee Stange vs Denny McLain | Second | 12 out |
| Sunday, August 7 |
| » Defeated Red Sox (46-67), 9-2 | Tiger Stadium (26-29) | 59-49 | |
| » Starters: Jim Lonborg vs Bill Monbouquette | Second | 11½ out |
| » Lost to Red Sox (47-67), 7-6 | Tiger Stadium (26-30) | 59-50 | |
| » Starters: Bucky Brandon vs Mickey Lolich | Second | 11½ out |
| Monday, August 8 |
| » Defeated Senators (51-65), 5-3 | Robert F. Kennedy Stadium (6-1) | 60-50 | |
| » Starters: Johnny Podres vs Mike McCormick | Second | 11 out |
| » Major-league debuts: Tim Cullen (Senators) |
| Tuesday, August 9 |
| » Defeated Senators (51-66), 8-3 | Robert F. Kennedy Stadium (7-1) | 61-50 | Won 2 |
| » Starters: Earl Wilson vs Frank Kreutzer | Second | 10 out |
| Future Tiger Bob Scanlan is born in Los Angeles, CA. |
| Wednesday, August 10 |
| » Lost to Senators (52-66), 6-3 | Robert F. Kennedy Stadium (7-2) | 61-51 | |
| » Starters: Denny McLain vs Jim Hannan | Second | 11 out |
| Friday, August 12 |
| » Lost to Red Sox (51-68), 13-9 | Fenway Park (3-3) | 61-52 | Lost 2 |
| » Starters: Bill Monbouquette vs Bucky Brandon | Second | 12 out |
| Saturday, August 13 |
| » Defeated Red Sox (51-69), 13-1 | Fenway Park (4-3) | 62-52 | |
| » Starters: Earl Wilson vs Jose Santiago | Second | 12 out |
| Sunday, August 14 |
| » Lost to Red Sox (52-69), 8-5 | Fenway Park (4-4) | 62-53 | |
| » Starters: Denny McLain vs Dennis Bennett | Second | 13½ out |
| » Lost to Red Sox (53-69), 5-3 | Fenway Park (4-5) | 62-54 | Lost 2 |
| » Starters: Joe Sparma vs Lee Stange | Second | 13½ out |
| Monday, August 15 |
| » Defeated Yankees (53-66), 6-5 | Tiger Stadium (27-30) | 63-54 | |
| » Starters: Mel Stottlemyre vs Mickey Lolich | Second | 13½ out |
| Tuesday, August 16 |
| » Defeated Yankees (53-67), 6-3 | Tiger Stadium (28-30) | 64-54 | Won 2 |
| » Starters: Al Downing vs Johnny Podres | Second | 13½ out |
| Wednesday, August 17 |
| » Defeated Yankees (53-68), 4-2 | Tiger Stadium (29-30) | 65-54 | Won 3 |
| » Starters: Jim Bouton vs Earl Wilson | Second | 13½ out |
| Friday, August 19 |
| » Defeated Orioles (79-42), 10-4 | Tiger Stadium (30-30) | 66-54 | Won 4 |
| » Starters: Eddie Watt vs Mickey Lolich | Second | 12½ out |
| Saturday, August 20 |
| » Lost to Orioles (80-42), 8-3 | Tiger Stadium (30-31) | 66-55 | |
| » Starters: Dave McNally vs Denny McLain | Second | 13½ out |
| Sunday, August 21 |
| » Defeated Orioles (80-43), 9-4 | Tiger Stadium (31-31) | 67-55 | |
| » Starters: Moe Drabowsky vs Earl Wilson | Second | 12½ out |
| Tuesday, August 23 |
| » Lost to White Sox (66-60), 2-1 | Tiger Stadium (31-32) | 67-56 | |
| » Starters: Gary Peters vs Johnny Podres | Second | 12½ out |
| Wednesday, August 24 |
| » Defeated White Sox (66-61), 6-2 | Tiger Stadium (32-32) | 68-56 | |
| » Starters: Tommy John vs Mickey Lolich | Second | 11½ out |
| Thursday, August 25 |
| » Defeated White Sox (66-62), 8-0 | Tiger Stadium (33-32) | 69-56 | Won 2 |
| » Starters: Joe Horlen vs Denny McLain | Second | 11½ out |
| Friday, August 26 |
| » Lost to Yankees (57-72), 6-5 | Yankee Stadium (5-2) | 69-57 | |
| » Starters: Earl Wilson vs Al Downing | Second | 12½ out |
| Saturday, August 27 |
| » Lost to Yankees (58-72), 11-1 | Yankee Stadium (5-3) | 69-58 | Lost 2 |
| » Starters: Johnny Podres vs Jim Bouton | Second | 12½ out |
| Sunday, August 28 |
| » Lost to Yankees (59-72), 8-1 | Yankee Stadium (5-4) | 69-59 | Lost 3 |
| » Starters: Mickey Lolich vs Fritz Peterson | Second | 12½ out |
| Monday, August 29 |
| » Defeated Orioles (82-48), 6-3 | Memorial Stadium (4-4) | 70-59 | |
| » Starters: Denny McLain vs Dave McNally | Second | 11½ out |
| Tuesday, August 30 |
| » Defeated Orioles (82-49), 5-4 | Memorial Stadium (5-4) | 71-59 | Won 2 |
| » Starters: Earl Wilson vs Eddie Watt | Second | 10½ out |
| Wednesday, August 31 |
| » Lost to White Sox (70-65), 7-6 | Comiskey Park I (3-4) | 71-60 | |
| » Starters: Hank Aguirre vs Dennis Higgins | Second | 12 out |
| » Lost to White Sox (71-65), 3-1 | Comiskey Park I (3-5) | 71-61 | Lost 2 |
| » Starters: Johnny Podres vs Gary Peters | Second | 12 out |
| Thursday, September 1 |
| » Defeated White Sox (71-66), 7-5 | Comiskey Park I (4-5) | 72-61 | |
| » Starters: Mickey Lolich vs Bruce Howard | Second | 11 out |
| Friday, September 2 |
| » Defeated Indians (70-66), 4-2 | Cleveland Stadium (4-2) | 73-61 | Won 2 |
| » Starters: Denny McLain vs Gary Bell | Second | 9½ out |
| » Defeated Indians (70-67), 7-5 | Cleveland Stadium (5-2) | 74-61 | Won 3 |
| » Starters: Joe Sparma vs John O'Donoghue | Second | 9½ out |
| Saturday, September 3 |
| » Defeated Indians (70-68), 8-1 | Cleveland Stadium (6-2) | 75-61 | Won 4 |
| » Starters: Earl Wilson vs Tom Kelley | Second | 9½ out |
| Sunday, September 4 |
| » Defeated Indians (70-69), 4-3 | Cleveland Stadium (7-2) | 76-61 | Won 5 |
| » Starters: Hank Aguirre vs Sam McDowell | Second | 9½ out |
| Monday, September 5 |
| » Lost to Senators (64-78), 6-4 | Tiger Stadium (33-33) | 76-62 | |
| » Starters: Mike McCormick vs Mickey Lolich | Second | 10½ out |
| » Defeated Senators (64-79), 7-4 | Tiger Stadium (34-33) | 77-62 | |
| » Starters: Frank Kreutzer vs Johnny Podres | Second | 10½ out |
| Tuesday, September 6 |
| » Defeated Senators (64-80), 8-2 | Tiger Stadium (35-33) | 78-62 | Won 2 |
| » Starters: Barry Moore vs Denny McLain | Second | 10½ out |
| » Major-league debuts: Dave Baldwin (Senators) |
| Wednesday, September 7 |
| » Defeated Senators (64-81), 4-0 | Tiger Stadium (36-33) | 79-62 | Won 3 |
| » Starters: Phil Ortega vs Earl Wilson | Second | 10½ out |
| Friday, September 9 |
| » Lost to Athletics (64-80), 2-1 | Municipal Stadium (3-4) | 79-63 | |
| » Starters: Johnny Podres vs Blue Moon Odom | Second | 10½ out |
| Saturday, September 10 |
| » Lost to Athletics (65-80), 5-0 | Municipal Stadium (3-5) | 79-64 | Lost 2 |
| » Starters: Denny McLain vs Jim Nash | Second | 10½ out |
| » Major-league debuts: George Korince (Tigers) |
| Future Tiger Riccardo Ingram is born in Douglas, GA. |
| Sunday, September 11 |
| » Lost to Athletics (66-80), 5-1 | Municipal Stadium (3-6) | 79-65 | Lost 3 |
| » Starters: Earl Wilson vs Lew Krausse | Third | 10½ out |
| Tuesday, September 13 |
| » Defeated Twins (80-66), 6-5 | Tiger Stadium (37-33) | 80-65 | |
| » Starters: Jim Kaat vs Mickey Lolich | Second | 9½ out |
| Former Tiger Ralph Comstock dies in Toledo, OH at the age of 76. |
| Wednesday, September 14 |
| » Defeated Twins (80-67), 3-2 | Tiger Stadium (38-33) | 81-65 | Won 2 |
| » Starters: Jim Perry vs Denny McLain | Second | 9 out |
| Thursday, September 15 |
| » Defeated Twins (80-68), 8-5 | Tiger Stadium (39-33) | 82-65 | Won 3 |
| » Starters: Mudcat Grant vs Johnny Podres | Second | 9½ out |
| » Major-league debuts: George Mitterwald (Twins) |
| Friday, September 16 |
| » Defeated Indians (73-77), 3-1 | Tiger Stadium (40-33) | 83-65 | Won 4 |
| » Starters: Gary Bell vs Hank Aguirre | Second | 8½ out |
| Saturday, September 17 |
| » Lost to Indians (74-77), 6-2 | Tiger Stadium (40-34) | 83-66 | |
| » Starters: Steve Hargan vs Mickey Lolich | Second | 8½ out |
| Sunday, September 18 |
| » Lost to Indians (75-77), 6-5 | Tiger Stadium (40-35) | 83-67 | Lost 2 |
| » Starters: Sam McDowell vs Denny McLain | Second | 8½ out |
| Wednesday, September 21 |
| » Defeated Angels (74-77), 2-1 | Tiger Stadium (41-35) | 84-67 | |
| » Starters: Dean Chance vs Earl Wilson | Second | 9½ out |
| Thursday, September 22 |
| » Lost to Angels (75-77), 5-3 | Tiger Stadium (41-36) | 84-68 | |
| » Starters: Fred Newman vs Mickey Lolich | Second | 10 out |
| » Defeated Angels (75-78), 7-0 | Tiger Stadium (42-36) | 85-68 | |
| » Starters: Jorge Rubio vs Johnny Podres | Second | 10 out |
| Friday, September 23 |
| » Lost to Twins (84-70), 12-4 | Metropolitan Stadium (4-3) | 85-69 | |
| » Starters: Denny McLain vs Mudcat Grant | Second | 10 out |
| » Major-league debuts: Arlo Brunsberg (Tigers) |
| Saturday, September 24 |
| » Defeated Twins (84-71), 8-1 | Metropolitan Stadium (5-3) | 86-69 | |
| » Starters: Dave Wickersham vs Jim Merritt | Second | 10 out |
| Sunday, September 25 |
| » Lost to Twins (85-71), 1-0 | Metropolitan Stadium (5-4) | 86-70 | |
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