| Friday, February 25 |
| Former Senator Garland Braxton dies in Norfolk, VA at the age of 66. |
| Monday, April 11 |
| » Lost to Indians (1-0), 5-2 | Robert F. Kennedy Stadium (0-1) | 0-1 | |
| » Starters: Sam McDowell vs Pete Richert | Third | 1 out |
| Friday, April 15 |
| » Lost to Tigers (4-0), 8-3 | Tiger Stadium (0-1) | 0-2 | Lost 2 |
| » Starters: Jim Duckworth vs Dave Wickersham | Seventh | 3 out |
| » Major-league debuts: Casey Cox (Senators) |
| Saturday, April 16 |
| » Lost to Tigers (5-0), 7-5 | Tiger Stadium (0-2) | 0-3 | Lost 3 |
| » Starters: Pete Richert vs Mickey Lolich | Seventh | 4 out |
| » Major-league debuts: Dick Lines (Senators) |
| Sunday, April 17 |
| » Defeated Tigers (5-1), 10-4 | Tiger Stadium (1-2) | 1-3 | |
| » Starters: Mike McCormick vs Hank Aguirre | Sixth | 3 out |
| Tuesday, April 19 |
| » Lost to Orioles (5-1), 14-8 | Memorial Stadium (0-1) | 1-4 | |
| » Starters: Phil Ortega vs Jim Palmer | Seventh | 4 out |
| Wednesday, April 20 |
| » Lost to Orioles (6-1), 6-3 | Memorial Stadium (0-2) | 1-5 | Lost 2 |
| » Starters: Pete Richert vs Wally Bunker | Seventh | 5 out |
| Saturday, April 23 |
| » Defeated Tigers (6-4), 5-3 | Robert F. Kennedy Stadium (1-1) | 2-5 | |
| » Starters: Mickey Lolich vs Mike McCormick | Seventh | 5 out |
| Sunday, April 24 |
| » Lost to Tigers (7-4), 4-0 | Robert F. Kennedy Stadium (1-2) | 2-6 | |
| » Starters: Bill Monbouquette vs Pete Richert | Eighth | 6 out |
| » Lost to Tigers (8-4), 4-1 | Robert F. Kennedy Stadium (1-3) | 2-7 | Lost 2 |
| » Starters: Joe Sparma vs Jim Duckworth | Eighth | 6 out |
| Monday, April 25 |
| » Lost to White Sox (7-3), 3-2 | Robert F. Kennedy Stadium (1-4) | 2-8 | Lost 3 |
| » Starters: Tommy John vs Phil Ortega | Ninth | 7 out |
| Tuesday, April 26 |
| » Lost to White Sox (8-3), 4-1 | Robert F. Kennedy Stadium (1-5) | 2-9 | Lost 4 |
| » Starters: Joe Horlen vs Diego Segui | Ninth | 8 out |
| Wednesday, April 27 |
| » Defeated Yankees (2-11), 2-0 | Yankee Stadium (1-0) | 3-9 | |
| » Starters: Mike McCormick vs Al Downing | Seventh | 7½ out |
| Sunday, May 1 |
| » Defeated Twins (4-7), 5-3 | Robert F. Kennedy Stadium (2-5) | 4-9 | Won 2 |
| » Starters: Jim Kaat vs Pete Richert | Seventh | 8½ out |
| » Lost to Twins (5-7), 3-1 | Robert F. Kennedy Stadium (2-6) | 4-10 | |
| » Starters: Mudcat Grant vs Mike McCormick | Seventh | 8½ out |
| Tuesday, May 3 |
| » Defeated Orioles (12-2), 3-0 | Robert F. Kennedy Stadium (3-6) | 5-10 | |
| » Starters: Jim Palmer vs Phil Ortega | Seventh | 8 out |
| Wednesday, May 4 |
| » Defeated Orioles (12-3), 3-2 | Robert F. Kennedy Stadium (4-6) | 6-10 | Won 2 |
| » Starters: Wally Bunker vs Jim Duckworth | Seventh | 8 out |
| Friday, May 6 |
| » Lost to Athletics (4-14), 2-1 | Municipal Stadium (0-1) | 6-11 | |
| » Starters: Pete Richert vs Chuck Dobson | Seventh | 8½ out |
| Saturday, May 7 |
| » Lost to Athletics (5-14), 5-2 | Municipal Stadium (0-2) | 6-12 | Lost 2 |
| » Starters: Mike McCormick vs Catfish Hunter | Seventh | 9½ out |
| Former Senator Bing Miller dies in Philadelphia, PA at the age of 72. |
| Sunday, May 8 |
| » Defeated Athletics (5-15), 3-2 | Municipal Stadium (1-2) | 7-12 | |
| » Starters: Phil Ortega vs Fred Talbot | Sixth | 8 out |
| Monday, May 9 |
| » Lost to Angels (13-9), 10-7 | Anaheim Stadium (0-1) | 7-13 | |
| » Starters: Tom Cheney vs Jim McGlothlin | Fifth | 8½ out |
| Tuesday, May 10 |
| » Defeated Angels (13-10), 4-1 | Anaheim Stadium (1-1) | 8-13 | |
| » Starters: Pete Richert vs Fred Newman | Seventh | 8½ out |
| Wednesday, May 11 |
| » Lost to Angels (14-10), 7-6 | Anaheim Stadium (1-2) | 8-14 | |
| » Starters: Mike McCormick vs George Brunet | Seventh | 8½ out |
| Thursday, May 12 |
| » Defeated Angels (14-11), 4-2 | Anaheim Stadium (2-2) | 9-14 | |
| » Starters: Phil Ortega vs Marcelino Lopez | Seventh | 7½ out |
| Friday, May 13 |
| » Lost to Twins (11-10), 9-5 | Metropolitan Stadium (0-1) | 9-15 | |
| » Starters: Jim Duckworth vs Jim Kaat | Seventh | 8½ out |
| Saturday, May 14 |
| » Defeated Twins (11-11), 5-4 | Metropolitan Stadium (1-1) | 10-15 | |
| » Starters: Pete Richert vs Mudcat Grant | Seventh | 8½ out |
| Sunday, May 15 |
| » Lost to Twins (12-11), 6-2 | Metropolitan Stadium (1-2) | 10-16 | |
| » Starters: Mike McCormick vs Jim Perry | Seventh | 9 out |
| Monday, May 16 |
| » Lost to Twins (13-11), 2-1 | Metropolitan Stadium (1-3) | 10-17 | Lost 2 |
| » Starters: Phil Ortega vs Camilo Pascual | Seventh | 9½ out |
| Tuesday, May 17 |
| » Lost to Indians (19-6), 3-2 | Cleveland Stadium (0-1) | 10-18 | Lost 3 |
| » Starters: Diego Segui vs Sam McDowell | Seventh | 10½ out |
| Wednesday, May 18 |
| » Defeated Indians (19-7), 4-3 | Cleveland Stadium (1-1) | 11-18 | |
| » Starters: Pete Richert vs Sonny Siebert | Seventh | 9½ out |
| Thursday, May 19 |
| » Defeated Indians (19-8), 7-2 | Cleveland Stadium (2-1) | 12-18 | Won 2 |
| » Starters: Mike McCormick vs Luis Tiant | Seventh | 8½ out |
| Friday, May 20 |
| » Defeated Angels (17-15), 6-5 | Robert F. Kennedy Stadium (5-6) | 13-18 | Won 3 |
| » Starters: George Brunet vs Phil Ortega | Seventh | 8½ out |
| Saturday, May 21 |
| » Defeated Angels (17-16), 5-3 | Robert F. Kennedy Stadium (6-6) | 14-18 | Won 4 |
| » Starters: Dean Chance vs Diego Segui | Seventh | 7½ out |
| Sunday, May 22 |
| » Defeated Angels (17-17), 6-2 | Robert F. Kennedy Stadium (7-6) | 15-18 | Won 5 |
| » Starters: Fred Newman vs Pete Richert | Seventh | 8½ out |
| » Lost to Angels (18-17), 2-1 | Robert F. Kennedy Stadium (7-7) | 15-19 | |
| » Starters: Jim McGlothlin vs Jim Hannan | Seventh | 8½ out |
| Monday, May 23 |
| » Lost to Athletics (12-21), 5-3 | Robert F. Kennedy Stadium (7-8) | 15-20 | Lost 2 |
| » Starters: Catfish Hunter vs Mike McCormick | Eighth | 9 out |
| Tuesday, May 24 |
| » Defeated Athletics (12-22), 2-1 | Robert F. Kennedy Stadium (8-8) | 16-20 | |
| » Starters: Chuck Dobson vs Phil Ortega | Seventh | 8½ out |
| Wednesday, May 25 |
| » Lost to Athletics (13-22), 3-1 | Robert F. Kennedy Stadium (8-9) | 16-21 | |
| » Starters: Fred Talbot vs Diego Segui | Eighth | 9½ out |
| Friday, May 27 |
| » Defeated Red Sox (15-23), 5-4 | Robert F. Kennedy Stadium (9-9) | 17-21 | |
| » Starters: Bob Sadowski vs Pete Richert | Seventh | 10 out |
| Saturday, May 28 |
| » Lost to Red Sox (16-23), 6-5 | Robert F. Kennedy Stadium (9-10) | 17-22 | |
| » Starters: Jim Lonborg vs Jim Hannan | Eighth | 11 out |
| Sunday, May 29 |
| » Defeated Red Sox (16-24), 3-2 | Robert F. Kennedy Stadium (10-10) | 18-22 | |
| » Starters: Jerry Stephenson vs Phil Ortega | Seventh | 9½ out |
| Monday, May 30 |
| » Lost to Yankees (18-21), 4-2 | Robert F. Kennedy Stadium (10-11) | 18-23 | |
| » Starters: Al Downing vs Mike McCormick | Seventh | 8½ out |
| » Defeated Yankees (18-22), 2-1 | Robert F. Kennedy Stadium (11-11) | 19-23 | |
| » Starters: Jim Bouton vs Diego Segui | Seventh | 8½ out |
| Tuesday, May 31 |
| » Defeated Yankees (18-23), 5-1 | Robert F. Kennedy Stadium (12-11) | 20-23 | Won 2 |
| » Starters: Mel Stottlemyre vs Pete Richert | Seventh | 8½ out |
| Wednesday, June 1 |
| » Defeated Red Sox (17-27), 6-3 | Fenway Park (1-0) | 21-23 | Won 3 |
| » Starters: Dick Bosman vs Jim Lonborg | Seventh | 8 out |
| » Lost to Red Sox (18-27), 5-0 | Fenway Park (1-1) | 21-24 | |
| » Starters: Jim Hannan vs Bob Sadowski | Seventh | 8 out |
| » Major-league debuts: Dick Bosman (Senators) |
| Thursday, June 2 |
| » Defeated Red Sox (18-28), 12-2 | Fenway Park (2-1) | 22-24 | |
| » Starters: Phil Ortega vs Jerry Stephenson | Fifth | 7 out |
| Friday, June 3 |
| » Lost to White Sox (21-22), 8-0 | Comiskey Park I (0-1) | 22-25 | |
| » Starters: Mike McCormick vs Jack Lamabe | Sixth | 8 out |
| Saturday, June 4 |
| » Lost to White Sox (22-22), 6-0 | Comiskey Park I (0-2) | 22-26 | Lost 2 |
| » Starters: Pete Richert vs John Buzhardt | Sixth | 9 out |
| Sunday, June 5 |
| » Lost to White Sox (23-22), 4-1 | Comiskey Park I (0-3) | 22-27 | Lost 3 |
| » Starters: Diego Segui vs Joe Horlen | Seventh | 9½ out |
| » Lost to White Sox (24-22), 12-0 | Comiskey Park I (0-4) | 22-28 | Lost 4 |
| » Starters: Dick Bosman vs Gary Peters | Seventh | 9½ out |
| Monday, June 6 |
| » Defeated Orioles (30-19), 5-3 | Robert F. Kennedy Stadium (13-11) | 23-28 | |
| » Starters: John Miller vs Phil Ortega | Seventh | 9 out |
| Tuesday, June 7 |
| » Lost to Orioles (31-19), 6-5 | Memorial Stadium (0-3) | 23-29 | |
| » Starters: Mike McCormick vs Frank Bertaina | Seventh | 9 out |
| Wednesday, June 8 |
| » Lost to Orioles (32-19), 6-5 | Memorial Stadium (0-4) | 23-30 | Lost 2 |
| » Starters: Pete Richert vs Jim Palmer | Seventh | 11 out |
| » Lost to Orioles (33-19), 8-7 | Memorial Stadium (0-5) | 23-31 | Lost 3 |
| » Starters: Jim Hannan vs Steve Barber | Seventh | 11 out |
| Thursday, June 9 |
| » Lost to Orioles (34-19), 4-2 | Memorial Stadium (0-6) | 23-32 | Lost 4 |
| » Starters: Diego Segui vs Dave McNally | Eighth | 12 out |
| Friday, June 10 |
| » Lost to Indians (32-18), 2-0 | Cleveland Stadium (2-2) | 23-33 | Lost 5 |
| » Starters: Phil Ortega vs Sonny Siebert | Eighth | 13 out |
| Saturday, June 11 |
| » Lost to Indians (33-18), 6-4 | Cleveland Stadium (2-3) | 23-34 | Lost 6 |
| » Starters: Mike McCormick vs Sam McDowell | Seventh | 13 out |
| Sunday, June 12 |
| » Lost to Indians (34-18), 6-3 | Cleveland Stadium (2-4) | 23-35 | Lost 7 |
| » Starters: Pete Richert vs Gary Bell | Ninth | 14 out |
| Monday, June 13 |
| » Lost to Tigers (34-21), 4-3 | Tiger Stadium (1-3) | 23-36 | Lost 8 |
| » Starters: Diego Segui vs Dave Wickersham | Ninth | 14½ out |
| Tuesday, June 14 |
| » Defeated Tigers (34-22), 3-2 | Tiger Stadium (2-3) | 24-36 | |
| » Starters: Phil Ortega vs Bill Monbouquette | Ninth | 15 out |
| Wednesday, June 15 |
| » Lost to Orioles (39-20), 6-4 | Robert F. Kennedy Stadium (13-12) | 24-37 | |
| » Starters: Wally Bunker vs Dick Bosman | Ninth | 16 out |
| Thursday, June 16 |
| » Defeated Orioles (39-21), 2-1 | Robert F. Kennedy Stadium (14-12) | 25-37 | |
| » Starters: Frank Bertaina vs Pete Richert | Seventh | 15 out |
| Friday, June 17 |
| » Defeated Indians (36-21), 5-4 | Robert F. Kennedy Stadium (15-12) | 26-37 | Won 2 |
| » Starters: Gary Bell vs Diego Segui | Eighth | 15 out |
| Saturday, June 18 |
| » Lost to Indians (37-21), 7-2 | Robert F. Kennedy Stadium (15-13) | 26-38 | |
| » Starters: Sonny Siebert vs Phil Ortega | Seventh | 16 out |
| Sunday, June 19 |
| » Defeated Indians (37-22), 2-1 | Robert F. Kennedy Stadium (16-13) | 27-38 | |
| » Starters: Jack Kralick vs Mike McCormick | Eighth | 15½ out |
| Monday, June 20 |
| » Defeated Indians (37-23), 4-2 | Robert F. Kennedy Stadium (17-13) | 28-38 | Won 2 |
| » Starters: John O'Donoghue vs Pete Richert | Seventh | 15 out |
| Tuesday, June 21 |
| » Lost to Tigers (39-23), 5-2 | Robert F. Kennedy Stadium (17-14) | 28-39 | |
| » Starters: Denny McLain vs Diego Segui | Seventh | 15½ out |
| Wednesday, June 22 |
| » Lost to Tigers (40-23), 12-2 | Robert F. Kennedy Stadium (17-15) | 28-40 | Lost 2 |
| » Starters: Mickey Lolich vs Phil Ortega | Eighth | 16½ out |
| Thursday, June 23 |
| » Lost to Tigers (41-23), 6-1 | Robert F. Kennedy Stadium (17-16) | 28-41 | Lost 3 |
| » Starters: Earl Wilson vs Mike McCormick | Ninth | 17½ out |
| Friday, June 24 |
| » Lost to Red Sox (24-44), 5-1 | Fenway Park (2-2) | 28-42 | Lost 4 |
| » Starters: Pete Richert vs Jose Santiago | Eighth | 17½ out |
| Saturday, June 25 |
| » Defeated Red Sox (24-45), 4-3 | Fenway Park (3-2) | 29-42 | |
| » Starters: Dick Bosman vs Rollie Sheldon | Ninth | 17½ out |
| Sunday, June 26 |
| » Lost to Red Sox (25-45), 13-7 | Fenway Park (3-3) | 29-43 | |
| » Starters: Phil Ortega vs Jim Lonborg | Ninth | 18 out |
| » Defeated Red Sox (25-46), 9-3 | Fenway Park (4-3) | 30-43 | |
| » Starters: Jim Hannan vs Dave Morehead | Ninth | 18 out |
| Tuesday, June 28 |
| » Defeated White Sox (32-38), 4-1 | Comiskey Park I (1-4) | 31-43 | Won 2 |
| » Starters: Mike McCormick vs Jack Lamabe | Ninth | 17½ out |
| Wednesday, June 29 |
| » Lost to White Sox (33-38), 5-0 | Comiskey Park I (1-5) | 31-44 | |
| » Starters: Pete Richert vs Bruce Howard | Ninth | 18½ out |
| Friday, July 1 |
| » Lost to Yankees (32-39), 8-6 | Robert F. Kennedy Stadium (17-17) | 31-45 | Lost 2 |
| » Starters: Fred Talbot vs Phil Ortega | Ninth | 20½ out |
| Saturday, July 2 |
| » Defeated Yankees (32-40), 10-4 | Robert F. Kennedy Stadium (18-17) | 32-45 | |
| » Starters: Whitey Ford vs Mike McCormick | Ninth | 21 out |
| Sunday, July 3 |
| » Lost to Yankees (33-40), 6-5 | Robert F. Kennedy Stadium (18-18) | 32-46 | |
| » Starters: Al Downing vs Pete Richert | Ninth | 22 out |
| Monday, July 4 |
| » Defeated Red Sox (28-51), 6-4 | Fenway Park (5-3) | 33-46 | |
| » Starters: Dick Bosman vs Jim Lonborg | Ninth | 21½ out |
| » Lost to Red Sox (29-51), 1-0 | Fenway Park (5-4) | 33-47 | |
| » Starters: Jim Hannan vs Lee Stange | Ninth | 21½ out |
| Wednesday, July 6 |
| » Defeated White Sox (37-41), 4-3 | Robert F. Kennedy Stadium (19-18) | 34-47 | |
| » Starters: John Buzhardt vs Phil Ortega | Ninth | 20½ out |
| » Defeated White Sox (37-42), 3-2 | Robert F. Kennedy Stadium (20-18) | 35-47 | Won 2 |
| » Starters: Joe Horlen vs Mike McCormick | Ninth | 20½ out |
| Former Senator Sad Sam Jones dies in Barnesville, OH at the age of 74. |
| Thursday, July 7 |
| » Lost to White Sox (38-42), 8-5 | Robert F. Kennedy Stadium (20-19) | 35-48 | |
| » Starters: Tommy John vs Pete Richert | Ninth | 21 out |
| Friday, July 8 |
| » Defeated Yankees (35-45), 7-6 | Yankee Stadium (2-0) | 36-48 | |
| » Starters: Dick Bosman vs Mel Stottlemyre | Ninth | 21½ out |
| » Lost to Yankees (36-45), 7-5 | Yankee Stadium (2-1) | 36-49 | |
| » Starters: Jim Hannan vs Fritz Peterson | Ninth | 21½ out |
| Saturday, July 9 |
| » Defeated Yankees (36-46), 3-0 | Yankee Stadium (3-1) | 37-49 | |
| » Starters: Diego Segui vs Fred Talbot | Ninth | 21 out |
| Sunday, July 10 |
| » Defeated Yankees (36-47), 3-2 | Yankee Stadium (4-1) | 38-49 | Won 2 |
| » Starters: Mike McCormick vs Jim Bouton | Eighth | 19½ out |
| » Defeated Yankees (36-48), 9-2 | Yankee Stadium (5-1) | 39-49 | Won 3 |
| » Starters: Bob Humphreys vs Dooley Womack | Eighth | 19½ out |
| Thursday, July 14 |
| » Lost to Twins (41-45), 3-1 | Metropolitan Stadium (1-4) | 39-50 | |
| » Starters: Phil Ortega vs Mudcat Grant | Seventh | 19½ out |
| Friday, July 15 |
| » Lost to Twins (42-45), 5-4 | Metropolitan Stadium (1-5) | 39-51 | Lost 2 |
| » Starters: Mike McCormick vs Jim Kaat | Seventh | 19½ out |
| Saturday, July 16 |
| » Lost to Twins (43-45), 6-2 | Metropolitan Stadium (1-6) | 39-52 | Lost 3 |
| » Starters: Diego Segui vs Dave Boswell | Ninth | 20½ out |
| Sunday, July 17 |
| » Lost to Angels (49-40), 5-0 | Anaheim Stadium (2-3) | 39-53 | Lost 4 |
| » Starters: Dick Bosman vs Clyde Wright | Ninth | 20½ out |
| » Defeated Angels (49-41), 3-1 | Anaheim Stadium (3-3) | 40-53 | |
| » Starters: Jim Hannan vs Jack Sanford | Ninth | 20½ out |
| Tuesday, July 19 |
| » Lost to Twins (44-48), 5-4 | Robert F. Kennedy Stadium (20-20) | 40-54 | |
| » Starters: Jim Kaat vs Pete Richert | Eighth | 22½ out |
| » Lost to Twins (45-48), 4-0 | Robert F. Kennedy Stadium (20-21) | 40-55 | Lost 2 |
| » Starters: Jim Perry vs Phil Ortega | Eighth | 22½ out |
| Wednesday, July 20 |
| » Lost to Twins (46-48), 3-1 | Robert F. Kennedy Stadium (20-22) | 40-56 | Lost 3 |
| » Starters: Dave Boswell vs Mike McCormick | Ninth | 23½ out |
| Thursday, July 21 |
| » Lost to Twins (47-48), 1-0 | Robert F. Kennedy Stadium (20-23) | 40-57 | Lost 4 |
| » Starters: Jim Merritt vs Jim Hannan | Tenth | 24½ out |
| Friday, July 22 |
| » Lost to Athletics (42-51), 7-2 | Robert F. Kennedy Stadium (20-24) | 40-58 | Lost 5 |
| » Starters: Jim Nash vs Diego Segui | Tenth | 25½ out |
| Saturday, July 23 |
| » Defeated Athletics (42-52), 8-1 | Robert F. Kennedy Stadium (21-24) | 41-58 | |
| » Starters: Bill Stafford vs Barry Moore | Tenth | 25½ out |
| Sunday, July 24 |
| » Defeated Athletics (42-53), 6-2 | Robert F. Kennedy Stadium (22-24) | 42-58 | Won 2 |
| » Starters: Catfish Hunter vs Pete Richert | Ninth | 24 out |
| » Defeated Athletics (42-54), 7-4 | Robert F. Kennedy Stadium (23-24) | 43-58 | Won 3 |
| » Starters: Jim Dickson vs Phil Ortega | Ninth | 24 out |
| Monday, July 25 |
| » Lost to Indians (52-45), 6-3 | Robert F. Kennedy Stadium (23-25) | 43-59 | |
| » Starters: Sonny Siebert vs Mike McCormick | Ninth | 24½ out |
| Tuesday, July 26 |
| » Defeated Angels (52-47), 6-2 | Robert F. Kennedy Stadium (24-25) | 44-59 | |
| » Starters: Fred Newman vs Jim Hannan | Ninth | 23½ out |
| Wednesday, July 27 |
| » Defeated Angels (52-48), 7-5 | Robert F. Kennedy Stadium (25-25) | 45-59 | Won 2 |
| » Starters: Clyde Wright vs Barry Moore | Ninth | 23½ out |
| Friday, July 29 |
| » Defeated Red Sox (43-60), 13-4 | Robert F. Kennedy Stadium (26-25) | 46-59 | Won 3 |
| » Starters: Bucky Brandon vs Pete Richert | Ninth | 23 out |
| » Defeated Red Sox (43-61), 6-5 | Robert F. Kennedy Stadium (27-25) | 47-59 | Won 4 |
| » Starters: Rollie Sheldon vs Phil Ortega | Ninth | 23 out |
| Saturday, July 30 |
| » Lost to Red Sox (44-61), 8-2 | Robert F. Kennedy Stadium (27-26) | 47-60 | |
| » Starters: Jose Santiago vs Mike McCormick | Ninth | 23 out |
| Former Senator Harry Hedgpeth dies in Richmond, VA at the age of 78. |
| Sunday, July 31 |
| » Lost to Red Sox (45-61), 5-2 | Robert F. Kennedy Stadium (27-27) | 47-61 | Lost 2 |
| » Starters: Dennis Bennett vs Jim Hannan | Ninth | 24 out |
| Monday, August 1 |
| » Defeated Athletics (45-58), 6-4 | Municipal Stadium (2-2) | 48-61 | |
| » Starters: Barry Moore vs Ralph Terry | Eighth | 23½ out |
| Tuesday, August 2 |
| » Lost to Athletics (46-58), 4-3 | Municipal Stadium (2-3) | 48-62 | |
| » Starters: Frank Kreutzer vs Lew Krausse | Ninth | 24½ out |
| Wednesday, August 3 |
| » Defeated Athletics (46-59), 4-3 | Municipal Stadium (3-3) | 49-62 | |
| » Starters: Pete Richert vs Blue Moon Odom | Eighth | 23½ out |
| Thursday, August 4 |
| » Lost to Athletics (47-59), 4-3 | Municipal Stadium (3-4) | 49-63 | |
| » Starters: Phil Ortega vs Jim Nash | Ninth | 23½ out |
| Friday, August 5 |
| » Defeated Orioles (70-38), 4-2 | Memorial Stadium (1-6) | 50-63 | |
| » Starters: Jim Hannan vs Eddie Watt | Ninth | 22½ out |
| Saturday, August 6 |
| » Lost to Orioles (71-38), 4-0 | Memorial Stadium (1-7) | 50-64 | |
| » Starters: Barry Moore vs Dave McNally | Ninth | 23½ out |
| Sunday, August 7 |
| » Defeated Orioles (71-39), 6-2 | Robert F. Kennedy Stadium (28-27) | 51-64 | |
| » Starters: John Miller vs Pete Richert | Ninth | 22½ out |
| Monday, August 8 |
| » Lost to Tigers (60-50), 5-3 | Robert F. Kennedy Stadium (28-28) | 51-65 | |
| » Starters: Johnny Podres vs Mike McCormick | Eighth | 23 out |
| » Major-league debuts: Tim Cullen (Senators) |
| Tuesday, August 9 |
| » Lost to Tigers (61-50), 8-3 | Robert F. Kennedy Stadium (28-29) | 51-66 | Lost 2 |
| » Starters: Earl Wilson vs Frank Kreutzer | Ninth | 23 out |
| Wednesday, August 10 |
| » Defeated Tigers (61-51), 6-3 | Robert F. Kennedy Stadium (29-29) | 52-66 | |
| » Starters: Denny McLain vs Jim Hannan | Ninth | 23 out |
| Friday, August 12 |
| » Lost to Orioles (74-40), 2-1 | Robert F. Kennedy Stadium (29-30) | 52-67 | |
| » Starters: Moe Drabowsky vs Pete Richert | Eighth | 23½ out |
| » Defeated Orioles (74-41), 4-1 | Robert F. Kennedy Stadium (30-30) | 53-67 | |
| » Starters: John Miller vs Barry Moore | Eighth | 23½ out |
| Saturday, August 13 |
| » Lost to Orioles (75-41), 5-2 | Memorial Stadium (1-8) | 53-68 | |
| » Starters: Phil Ortega vs Jim Palmer | Seventh | 24½ out |
| Sunday, August 14 |
| » Lost to Orioles (76-41), 6-0 | Robert F. Kennedy Stadium (30-31) | 53-69 | Lost 2 |
| » Starters: Eddie Watt vs Frank Kreutzer | Eighth | 25½ out |
| Monday, August 15 |
| » Lost to Indians (63-56), 4-3 | Cleveland Stadium (2-5) | 53-70 | Lost 3 |
| » Starters: Mike McCormick vs Sonny Siebert | Ninth | 26½ out |
| Tuesday, August 16 |
| » Defeated Indians (63-57), 6-5 | Cleveland Stadium (3-5) | 54-70 | |
| » Starters: Jim Hannan vs Gary Bell | Ninth | 26½ out |
| Wednesday, August 17 |
| » Lost to Indians (64-57), 5-3 | Cleveland Stadium (3-6) | 54-71 | |
| » Starters: Pete Richert vs Steve Hargan | Seventh | 27½ out |
| Friday, August 19 |
| » Defeated Angels (60-62), 5-3 | Robert F. Kennedy Stadium (31-31) | 55-71 | |
| » Starters: Jim Coates vs Barry Moore | Eighth | 26½ out |
| Saturday, August 20 |
| » Lost to Angels (61-62), 5-4 | Robert F. Kennedy Stadium (31-32) | 55-72 | |
| » Starters: George Brunet vs Mike McCormick | Eighth | 27½ out |
| Sunday, August 21 |
| » Defeated Angels (61-63), 7-4 | Robert F. Kennedy Stadium (32-32) | 56-72 | |
| » Starters: Ramon Lopez vs Phil Ortega | Seventh | 26½ out |
| Tuesday, August 23 |
| » Lost to Twins (67-59), 7-0 | Robert F. Kennedy Stadium (32-33) | 56-73 | |
| » Starters: Jim Kaat vs Pete Richert | Eighth | 26 out |
| » Defeated Twins (67-60), 4-3 | Robert F. Kennedy Stadium (33-33) | 57-73 | |
| » Starters: Mudcat Grant vs Frank Kreutzer | Eighth | 26 out |
| Wednesday, August 24 |
| » Defeated Twins (67-61), 6-5 | Robert F. Kennedy Stadium (34-33) | 58-73 | Won 2 |
| » Starters: Jim Perry vs Barry Moore | Seventh | 25 out |
| Friday, August 26 |
| » Defeated Indians (68-61), 1-0 | Robert F. Kennedy Stadium (35-33) | 59-73 | Won 3 |
| » Starters: Steve Hargan vs Mike McCormick | Sixth | 25½ out |
| Saturday, August 27 |
| » Defeated Indians (68-62), 3-1 | Robert F. Kennedy Stadium (36-33) | 60-73 | Won 4 |
| » Starters: Sam McDowell vs Phil Ortega | Seventh | 24½ out |
| Sunday, August 28 |
| » Defeated Indians (68-63), 3-2 | Robert F. Kennedy Stadium (37-33) | 61-73 | Won 5 |
| » Starters: Sonny Siebert vs Pete Richert | Seventh | 23½ out |
| Monday, August 29 |
| » Lost to Twins (70-63), 6-1 | Metropolitan Stadium (1-7) | 61-74 | |
| » Starters: Frank Kreutzer vs Jim Perry | Eighth | 23½ out |
| Tuesday, August 30 |
| » Lost to Twins (71-63), 3-1 | Metropolitan Stadium (1-8) | 61-75 | Lost 2 |
| » Starters: Jim Hannan vs Jim Merritt | Eighth | 23½ out |
| Wednesday, August 31 |
| » Defeated Athletics (58-77), 3-0 | Municipal Stadium (4-4) | 62-75 | |
| » Starters: Mike McCormick vs Gil Blanco | Seventh | 24 out |
| » Lost to Athletics (59-77), 4-0 | Municipal Stadium (4-5) | 62-76 | |
| » Starters: Barry Moore vs Paul Lindblad | Seventh | 24 out |
| Friday, September 2 |
| » Lost to Angels (68-67), 6-5 | Anaheim Stadium (3-4) | 62-77 | Lost 2 |
| » Starters: Phil Ortega vs Fred Newman | Eighth | 23½ out |
| Saturday, September 3 |
| » Lost to Angels (69-67), 7-6 | Anaheim Stadium (3-5) | 62-78 | Lost 3 |
| » Starters: Pete Richert vs George Brunet | Eighth | 24½ out |
| Sunday, September 4 |
| » Defeated Angels (69-68), 5-3 | Anaheim Stadium (4-5) | 63-78 | |
| » Starters: Jim Hannan vs Dean Chance | Seventh | 24½ out |
| Monday, September 5 |
| » Defeated Tigers (76-62), 6-4 | Tiger Stadium (3-3) | 64-78 | Won 2 |
| » Starters: Mike McCormick vs Mickey Lolich | Seventh | 25½ out |
| » Lost to Tigers (77-62), 7-4 | Tiger Stadium (3-4) | 64-79 | |
| » Starters: Frank Kreutzer vs Johnny Podres | Seventh | 25½ out |
| Tuesday, September 6 |
| » Lost to Tigers (78-62), 8-2 | Tiger Stadium (3-5) | 64-80 | Lost 2 |
| » Starters: Barry Moore vs Denny McLain | Seventh | 26½ out |
| » Major-league debuts: Dave Baldwin (Senators) |
| Wednesday, September 7 |
| » Lost to Tigers (79-62), 4-0 | Tiger Stadium (3-6) | 64-81 | Lost 3 |
| » Starters: Phil Ortega vs Earl Wilson | Eighth | 27½ out |
| Friday, September 9 |
| » Lost to White Sox (74-70), 1-0 | Comiskey Park I (1-6) | 64-82 | Lost 4 |
| » Starters: Pete Richert vs Gary Peters | Ninth | 27½ out |
| » Major-league debuts: Buddy Bradford (White Sox) Hank Allen (Senators) |
| Saturday, September 10 |
| » Lost to White Sox (75-70), 1-0 | Comiskey Park I (1-7) | 64-83 | Lost 5 |
| » Starters: Mike McCormick vs Bruce Howard | Ninth | 27½ out |
| Sunday, September 11 |
| » Lost to White Sox (76-70), 4-1 | Comiskey Park I (1-8) | 64-84 | Lost 6 |
| » Starters: Jim Hannan vs Fred Klages | Ninth | 27½ out |
| » Major-league debuts: Ed Stroud (White Sox) |
| Tuesday, September 13 |
| » Defeated Yankees (65-82), 3-2 | Yankee Stadium (6-1) | 65-84 | |
| » Starters: Phil Ortega vs Fritz Peterson | Ninth | 26½ out |
| » Major-league debuts: Bill Henry (Yankees) |
| Thursday, September 15 |
| » Defeated Yankees (65-83), 5-4 | Yankee Stadium (7-1) | 66-84 | Won 2 |
| » Starters: Pete Richert vs Mel Stottlemyre | Tenth | 27½ out |
| » Lost to Yankees (66-83), 10-5 | Yankee Stadium (7-2) | 66-85 | |
| » Starters: Mike McCormick vs Stan Bahnsen | Tenth | 27½ out |
| Friday, September 16 |
| » Game at Robert F. Kennedy Stadium interrupted in the 3rd inning with the score of Athletics 0, Senators 0. Completed on September 18. |
| Sunday, September 18 |
| » Lost to Athletics (70-80), 3-0 | Robert F. Kennedy Stadium (37-34) | 66-86 | Lost 2 |
| » Starters: Lew Krausse vs Barry Moore | Ninth | 26 out |
| » Defeated Athletics (70-81), 1-0 | Robert F. Kennedy Stadium (38-34) | 67-86 | |
| » Starters: Blue Moon Odom vs Phil Ortega | Ninth | 26 out |
| Friday, September 23 |
| » Defeated White Sox (80-74), 5-4 | Robert F. Kennedy Stadium (39-34) | 68-86 | Won 2 |
| » Starters: Tommy John vs Pete Richert | Ninth | 27 out |
| Saturday, September 24 |
| » Lost to White Sox (81-74), 6-2 | Robert F. Kennedy Stadium (39-35) | 68-87 | |
| » Starters: Bruce Howard vs Mike McCormick | Ninth | 28 out |
| Sunday, September 25 |
| » Defeated White Sox (81-75), 6-4 | Robert F. Kennedy Stadium (40-35) | 69-87 | |
| » Starters: Jack Lamabe vs Phil Ortega | Eighth | 26½ out |
| » Defeated White Sox (81-76), 2-1 | Robert F. Kennedy Stadium (41-35) | 70-87 | Won 2 |
| » Starters: Fred Klages vs Barry Moore | Eighth | 26½ out |
| Former Senator Jim Stevens dies in Baltimore, MD at the age of 78. |
| Monday, September 26 |
| » Lost to Red Sox (71-88), 5-0 | Robert F. Kennedy Stadium (41-36) | 70-88 | |
| » Starters: Bucky Brandon vs Jim Hannan | Eighth | 26½ out |
| » Defeated Red Sox (71-89), 3-2 | Robert F. Kennedy Stadium (42-36) | 71-88 | |
| » Starters: Dennis Bennett vs Joe Coleman | Eighth | 26½ out |
| Monday, October 10 |
| Former Senator Patsy Gharrity dies in Beloit, WI at the age of 75. |
Game information provided by Retrosheet (www.retrosheet.org) |
