| Friday, January 21 |
| Future Red Sox Chris Hammond is born in Atlanta, GA. |
| Monday, January 31 |
| Former Red Sox Pat Donahue dies in Springfield, OH at the age of 82. |
| Monday, February 14 |
| Former Red Sox Jack Coffey dies in Bronx, NY at the age of 80. |
| Friday, February 18 |
| Former Red Sox Marty McManus dies in St.Louis, MO at the age of 66. |
| Wednesday, March 9 |
| Former Red Sox Aaron Robinson dies in Lancaster, SC at the age of 51. Former Red Sox Elmer Steele dies in Rhinebeck, NY at the age of 80. |
| Thursday, March 10 |
| Future Red Sox Mike Timlin is born in Midland, TX. |
| Tuesday, March 29 |
| Future Red Sox Eric Gunderson is born in Portland, OR. |
| Tuesday, April 12 |
| » Lost to Orioles (1-0), 5-4 | Fenway Park (0-1) | 0-1 | |
| » Starters: Steve Barber vs Earl Wilson | Second | 1 out |
| » Major-league debuts: Guido Grilli and George Scott (Red Sox) Eddie Watt (Orioles) |
| Former Red Sox Joe Harris dies in Melrose, MA at the age of 85. |
| Wednesday, April 13 |
| » Lost to Orioles (2-0), 8-1 | Fenway Park (0-2) | 0-2 | Lost 2 |
| » Starters: Jim Palmer vs Dave Morehead | Fourth | 2 out |
| » Major-league debuts: Joe Foy and Pete Magrini (Red Sox) |
| Future Red Sox Wes Chamberlain is born in Chicago, IL. |
| Friday, April 15 |
| » Lost to Indians (2-0), 8-7 | Cleveland Stadium (0-1) | 0-3 | Lost 3 |
| » Starters: Jerry Stephenson vs Sam McDowell | Eighth | 3½ out |
| Saturday, April 16 |
| » Lost to Indians (3-0), 3-2 | Cleveland Stadium (0-2) | 0-4 | Lost 4 |
| » Starters: Dick Stigman vs Gary Bell | Eighth | 4½ out |
| Sunday, April 17 |
| » Lost to Indians (4-0), 6-0 | Cleveland Stadium (0-3) | 0-5 | Lost 5 |
| » Starters: Earl Wilson vs Luis Tiant | Eighth | 4½ out |
| Tuesday, April 19 |
| » Defeated Tigers (5-2), 7-0 | Fenway Park (1-2) | 1-5 | |
| » Starters: Bill Monbouquette vs Dave Morehead | Ninth | 5 out |
| » Lost to Tigers (6-2), 6-4 | Fenway Park (1-3) | 1-6 | |
| » Starters: Denny McLain vs Jim Lonborg | Ninth | 5 out |
| » Major-league debuts: Darrell Brandon (Red Sox) |
| Wednesday, April 20 |
| » Defeated Tigers (6-3), 5-3 | Fenway Park (2-3) | 2-6 | |
| » Starters: Dave Wickersham vs Jerry Stephenson | Sixth | 5 out |
| Thursday, April 21 |
| Future Red Sox Chris Donnels is born in Los Angeles, CA. |
| Friday, April 22 |
| Former Red Sox Lou Finney dies in Lafayette, AL at the age of 56. |
| Saturday, April 23 |
| » Lost to Indians (7-0), 5-4 | Fenway Park (2-4) | 2-7 | |
| » Starters: Gary Bell vs Dick Stigman | Eighth | 6 out |
| Monday, April 25 |
| » Defeated Yankees (1-10), 8-5 | Yankee Stadium (1-0) | 3-7 | |
| » Starters: Earl Wilson vs Bob Friend | Seventh | 6 out |
| Tuesday, April 26 |
| » Lost to Yankees (2-10), 7-6 | Yankee Stadium (1-1) | 3-8 | |
| » Starters: Jim Lonborg vs Whitey Ford | Seventh | 7 out |
| Wednesday, April 27 |
| » Lost to White Sox (9-3), 8-6 | Fenway Park (2-5) | 3-9 | Lost 2 |
| » Starters: John Buzhardt vs Jerry Stephenson | Seventh | 7½ out |
| Saturday, April 30 |
| » Lost to Angels (7-6), 16-9 | Fenway Park (2-6) | 3-10 | Lost 3 |
| » Starters: Dean Chance vs Earl Wilson | Eighth | 8½ out |
| Sunday, May 1 |
| » Lost to Angels (8-6), 6-1 | Fenway Park (2-7) | 3-11 | Lost 4 |
| » Starters: Jim McGlothlin vs Dick Stigman | Eighth | 9 out |
| » Defeated Angels (8-7), 9-1 | Fenway Park (3-7) | 4-11 | |
| » Starters: Jack Sanford vs Jerry Stephenson | Eighth | 9 out |
| Tuesday, May 3 |
| » Lost to Tigers (11-7), 8-0 | Tiger Stadium (0-1) | 4-12 | |
| » Starters: Jose Santiago vs Mickey Lolich | Eighth | 9½ out |
| Wednesday, May 4 |
| » Defeated Tigers (11-8), 7-0 | Tiger Stadium (1-1) | 5-12 | |
| » Starters: Earl Wilson vs Bill Monbouquette | Eighth | 9½ out |
| Friday, May 6 |
| » Lost to Twins (8-7), 5-4 | Metropolitan Stadium (0-1) | 5-13 | |
| » Starters: Dick Stigman vs Dave Boswell | Eighth | 10 out |
| Saturday, May 7 |
| » Lost to Twins (9-7), 6-4 | Metropolitan Stadium (0-2) | 5-14 | Lost 2 |
| » Starters: Jerry Stephenson vs Camilo Pascual | Eighth | 11 out |
| Former Red Sox Bing Miller dies in Philadelphia, PA at the age of 72. |
| Sunday, May 8 |
| » Defeated Twins (9-8), 8-1 | Metropolitan Stadium (1-2) | 6-14 | |
| » Starters: Earl Wilson vs Jim Kaat | Seventh | 9 out |
| » Defeated Twins (9-9), 4-1 | Metropolitan Stadium (2-2) | 7-14 | Won 2 |
| » Starters: Jose Santiago vs Mudcat Grant | Seventh | 9 out |
| Monday, May 9 |
| » Lost to Athletics (6-15), 6-1 | Municipal Stadium (0-1) | 7-15 | |
| » Starters: Pete Magrini vs Rollie Sheldon | Sixth | 9½ out |
| Tuesday, May 10 |
| » Lost to Athletics (7-15), 3-2 | Municipal Stadium (0-2) | 7-16 | Lost 2 |
| » Starters: Dick Stigman vs Ralph Terry | Ninth | 10½ out |
| Wednesday, May 11 |
| » Lost to Athletics (8-15), 6-5 | Municipal Stadium (0-3) | 7-17 | Lost 3 |
| » Starters: Jose Santiago vs Catfish Hunter | Tenth | 10½ out |
| Friday, May 13 |
| » Lost to Angels (15-11), 4-1 | Anaheim Stadium (0-1) | 7-18 | Lost 4 |
| » Starters: Jerry Stephenson vs Dean Chance | Tenth | 11 out |
| Saturday, May 14 |
| » Lost to Angels (16-11), 6-4 | Anaheim Stadium (0-2) | 7-19 | Lost 5 |
| » Starters: Earl Wilson vs Jim McGlothlin | Tenth | 12 out |
| Sunday, May 15 |
| » Lost to Angels (17-11), 5-4 | Anaheim Stadium (0-3) | 7-20 | Lost 6 |
| » Starters: Dick Stigman vs Fred Newman | Tenth | 12 out |
| » Defeated Angels (17-12), 6-3 | Anaheim Stadium (1-3) | 8-20 | |
| » Starters: Jose Santiago vs George Brunet | Tenth | 12 out |
| Tuesday, May 17 |
| » Lost to Orioles (18-9), 8-6 | Memorial Stadium (0-1) | 8-21 | |
| » Starters: Jerry Stephenson vs Frank Bertaina | Tenth | 13 out |
| Wednesday, May 18 |
| » Defeated Orioles (18-10), 2-1 | Memorial Stadium (1-1) | 9-21 | |
| » Starters: Earl Wilson vs Jim Palmer | Ninth | 12 out |
| Thursday, May 19 |
| » Defeated Orioles (18-11), 3-1 | Memorial Stadium (2-1) | 10-21 | Won 2 |
| » Starters: Dick Stigman vs Steve Barber | Tenth | 11 out |
| Friday, May 20 |
| » Defeated Athletics (11-19), 3-0 | Fenway Park (4-7) | 11-21 | Won 3 |
| » Starters: Fred Talbot vs Jose Santiago | Tenth | 11 out |
| Saturday, May 21 |
| » Defeated Athletics (11-20), 6-5 | Fenway Park (5-7) | 12-21 | Won 4 |
| » Starters: Rollie Sheldon vs Jerry Stephenson | Ninth | 10 out |
| Sunday, May 22 |
| » Defeated Athletics (11-21), 5-1 | Fenway Park (6-7) | 13-21 | Won 5 |
| » Starters: Ralph Terry vs Earl Wilson | Eighth | 10½ out |
| Tuesday, May 24 |
| » Defeated Twins (16-16), 11-2 | Fenway Park (7-7) | 14-21 | Won 6 |
| » Starters: Camilo Pascual vs Jose Santiago | Ninth | 10 out |
| Wednesday, May 25 |
| » Lost to Twins (17-16), 7-5 | Fenway Park (7-8) | 14-22 | |
| » Starters: Jim Kaat vs Jerry Stephenson | Ninth | 11 out |
| Future Red Sox Bill Haselman is born in Long Branch, NJ. Future Red Sox Dave Hollins is born in Buffalo, NY. |
| Thursday, May 26 |
| » Defeated Twins (17-17), 7-2 | Fenway Park (8-8) | 15-22 | |
| » Starters: Mudcat Grant vs Earl Wilson | Eighth | 11 out |
| Friday, May 27 |
| » Lost to Senators (17-21), 5-4 | Robert F. Kennedy Stadium (0-1) | 15-23 | |
| » Starters: Bob Sadowski vs Pete Richert | Ninth | 12 out |
| Saturday, May 28 |
| » Defeated Senators (17-22), 6-5 | Robert F. Kennedy Stadium (1-1) | 16-23 | |
| » Starters: Jim Lonborg vs Jim Hannan | Ninth | 12 out |
| Sunday, May 29 |
| » Lost to Senators (18-22), 3-2 | Robert F. Kennedy Stadium (1-2) | 16-24 | |
| » Starters: Jerry Stephenson vs Phil Ortega | Ninth | 11½ out |
| Monday, May 30 |
| » Lost to White Sox (18-20), 1-0 | Comiskey Park I (0-1) | 16-25 | Lost 2 |
| » Starters: Earl Wilson vs John Buzhardt | Ninth | 11½ out |
| » Lost to White Sox (19-20), 11-0 | Comiskey Park I (0-2) | 16-26 | Lost 3 |
| » Starters: Jose Santiago vs Jack Lamabe | Ninth | 11½ out |
| Tuesday, May 31 |
| » Defeated White Sox (19-21), 1-0 | Comiskey Park I (1-2) | 17-26 | |
| » Starters: Dick Stigman vs Joe Horlen | Ninth | 11½ out |
| Wednesday, June 1 |
| » Lost to Senators (21-23), 6-3 | Fenway Park (8-9) | 17-27 | |
| » Starters: Dick Bosman vs Jim Lonborg | Ninth | 11 out |
| » Defeated Senators (21-24), 5-0 | Fenway Park (9-9) | 18-27 | |
| » Starters: Jim Hannan vs Bob Sadowski | Ninth | 11 out |
| » Major-league debuts: Dick Bosman (Senators) |
| Thursday, June 2 |
| » Lost to Senators (22-24), 12-2 | Fenway Park (9-10) | 18-28 | |
| » Starters: Phil Ortega vs Jerry Stephenson | Tenth | 11 out |
| Friday, June 3 |
| » Lost to Yankees (20-24), 15-5 | Fenway Park (9-11) | 18-29 | Lost 2 |
| » Starters: Al Downing vs Earl Wilson | Ninth | 12 out |
| Saturday, June 4 |
| » Defeated Yankees (20-25), 6-3 | Fenway Park (10-11) | 19-29 | |
| » Starters: Mel Stottlemyre vs Jose Santiago | Eighth | 12 out |
| Sunday, June 5 |
| » Lost to Yankees (21-25), 5-3 | Fenway Park (10-12) | 19-30 | |
| » Starters: Jim Bouton vs Jim Lonborg | Ninth | 12 out |
| Tuesday, June 7 |
| » Lost to Tigers (29-19), 2-1 | Tiger Stadium (1-2) | 19-31 | Lost 2 |
| » Starters: Bob Sadowski vs Mickey Lolich | Ninth | 12 out |
| Future Red Sox Heathcliff Slocumb is born in Jamaica, NY. |
| Wednesday, June 8 |
| » Lost to Tigers (30-19), 5-4 | Tiger Stadium (1-3) | 19-32 | Lost 3 |
| » Starters: Earl Wilson vs Denny McLain | Ninth | 13½ out |
| Thursday, June 9 |
| » Lost to Tigers (31-19), 9-1 | Tiger Stadium (1-4) | 19-33 | Lost 4 |
| » Starters: Jose Santiago vs Dave Wickersham | Tenth | 14½ out |
| Friday, June 10 |
| » Lost to Orioles (35-19), 9-2 | Memorial Stadium (2-2) | 19-34 | Lost 5 |
| » Starters: Lee Stange vs Wally Bunker | Tenth | 15½ out |
| Saturday, June 11 |
| » Defeated Orioles (35-20), 8-2 | Memorial Stadium (3-2) | 20-34 | |
| » Starters: Jim Lonborg vs John Miller | Ninth | 14½ out |
| Sunday, June 12 |
| » Lost to Orioles (36-20), 8-1 | Memorial Stadium (3-3) | 20-35 | |
| » Starters: Earl Wilson vs Steve Barber | Tenth | 15½ out |
| Tuesday, June 14 |
| » Lost to Indians (35-18), 8-7 | Cleveland Stadium (0-4) | 20-36 | Lost 2 |
| » Starters: Jose Santiago vs Sonny Siebert | Tenth | 16½ out |
| » Defeated Indians (35-19), 11-7 | Cleveland Stadium (1-4) | 21-36 | |
| » Starters: Dick Stigman vs Luis Tiant | Tenth | 16½ out |
| Wednesday, June 15 |
| » Lost to Tigers (35-22), 11-7 | Fenway Park (10-13) | 21-37 | |
| » Starters: Joe Sparma vs Jim Lonborg | Tenth | 17½ out |
| Thursday, June 16 |
| » Lost to Tigers (36-22), 16-4 | Fenway Park (10-14) | 21-38 | Lost 2 |
| » Starters: Denny McLain vs Rollie Sheldon | Ninth | 17½ out |
| Friday, June 17 |
| » Lost to Orioles (40-21), 5-3 | Fenway Park (10-15) | 21-39 | Lost 3 |
| » Starters: Steve Barber vs Jim Lonborg | Tenth | 18½ out |
| Saturday, June 18 |
| » Lost to Orioles (41-21), 16-6 | Fenway Park (10-16) | 21-40 | Lost 4 |
| » Starters: Jim Palmer vs Bob Sadowski | Ninth | 19½ out |
| Sunday, June 19 |
| » Lost to Orioles (42-21), 5-3 | Fenway Park (10-17) | 21-41 | Lost 5 |
| » Starters: Dave McNally vs Lee Stange | Tenth | 19½ out |
| » Defeated Orioles (42-22), 5-2 | Fenway Park (11-17) | 22-41 | |
| » Starters: John Miller vs Jose Santiago | Tenth | 19½ out |
| Tuesday, June 21 |
| » Lost to Indians (38-23), 2-1 | Fenway Park (11-18) | 22-42 | |
| » Starters: Gary Bell vs Rollie Sheldon | Ninth | 20 out |
| Wednesday, June 22 |
| » Lost to Indians (39-23), 3-2 | Fenway Park (11-19) | 22-43 | Lost 2 |
| » Starters: Steve Hargan vs Jim Lonborg | Tenth | 20½ out |
| » Defeated Indians (39-24), 6-5 | Fenway Park (12-19) | 23-43 | |
| » Starters: Sonny Siebert vs Bob Sadowski | Tenth | 20½ out |
| Thursday, June 23 |
| » Lost to Indians (40-24), 8-6 | Fenway Park (12-20) | 23-44 | |
| » Starters: Luis Tiant vs Lee Stange | Tenth | 21½ out |
| Friday, June 24 |
| » Defeated Senators (28-42), 5-1 | Fenway Park (13-20) | 24-44 | |
| » Starters: Pete Richert vs Jose Santiago | Ninth | 20½ out |
| Saturday, June 25 |
| » Lost to Senators (29-42), 4-3 | Fenway Park (13-21) | 24-45 | |
| » Starters: Dick Bosman vs Rollie Sheldon | Tenth | 21½ out |
| Sunday, June 26 |
| » Defeated Senators (29-43), 13-7 | Fenway Park (14-21) | 25-45 | |
| » Starters: Phil Ortega vs Jim Lonborg | Tenth | 22 out |
| » Lost to Senators (30-43), 9-3 | Fenway Park (14-22) | 25-46 | |
| » Starters: Jim Hannan vs Dave Morehead | Tenth | 22 out |
| Tuesday, June 28 |
| » Defeated Yankees (30-38), 5-3 | Fenway Park (15-22) | 26-46 | |
| » Starters: Al Downing vs Jose Santiago | Tenth | 21½ out |
| Wednesday, June 29 |
| » Lost to Yankees (31-38), 6-5 | Fenway Park (15-23) | 26-47 | |
| » Starters: Mel Stottlemyre vs Rollie Sheldon | Tenth | 22½ out |
| Future Red Sox Peter Hoy is born in Brockville, ON. |
| Thursday, June 30 |
| » Defeated Yankees (31-39), 3-2 | Fenway Park (16-23) | 27-47 | |
| » Starters: Jim Bouton vs Jim Lonborg | Tenth | 22½ out |
| Friday, July 1 |
| » Lost to White Sox (34-38), 2-1 | Comiskey Park I (1-3) | 27-48 | |
| » Starters: Bucky Brandon vs John Buzhardt | Tenth | 24 out |
| Saturday, July 2 |
| » Lost to White Sox (35-38), 6-0 | Comiskey Park I (1-4) | 27-49 | Lost 2 |
| » Starters: Jose Santiago vs Joe Horlen | Tenth | 25½ out |
| Sunday, July 3 |
| » Defeated White Sox (35-39), 5-2 | Comiskey Park I (2-4) | 28-49 | |
| » Starters: Rollie Sheldon vs Jack Lamabe | Tenth | 26 out |
| » Lost to White Sox (36-39), 3-2 | Comiskey Park I (2-5) | 28-50 | |
| » Starters: Dick Stigman vs Tommy John | Tenth | 26 out |
| Monday, July 4 |
| » Lost to Senators (33-46), 6-4 | Fenway Park (16-24) | 28-51 | Lost 2 |
| » Starters: Dick Bosman vs Jim Lonborg | Tenth | 25½ out |
| » Defeated Senators (33-47), 1-0 | Fenway Park (17-24) | 29-51 | |
| » Starters: Jim Hannan vs Lee Stange | Tenth | 25½ out |
| Tuesday, July 5 |
| » Defeated Yankees (34-42), 7-1 | Yankee Stadium (2-1) | 30-51 | Won 2 |
| » Starters: Bucky Brandon vs Fred Talbot | Tenth | 25 out |
| Former Red Sox Pete Fox dies in Detroit, MI at the age of 58. |
| Wednesday, July 6 |
| » Defeated Yankees (34-43), 5-3 | Yankee Stadium (3-1) | 31-51 | Won 3 |
| » Starters: Jose Santiago vs Whitey Ford | Tenth | 24 out |
| » Defeated Yankees (34-44), 5-4 | Yankee Stadium (4-1) | 32-51 | Won 4 |
| » Starters: Dave Morehead vs Jim Bouton | Tenth | 24 out |
| Former Red Sox Sad Sam Jones dies in Barnesville, OH at the age of 74. |
| Thursday, July 7 |
| » Lost to Yankees (35-44), 5-2 | Yankee Stadium (4-2) | 32-52 | |
| » Starters: Rollie Sheldon vs Al Downing | Tenth | 24½ out |
| Friday, July 8 |
| » Defeated White Sox (38-43), 3-1 | Fenway Park (18-24) | 33-52 | |
| » Starters: Jack Lamabe vs Jim Lonborg | Tenth | 24 out |
| » Defeated White Sox (38-44), 5-1 | Fenway Park (19-24) | 34-52 | Won 2 |
| » Starters: Bruce Howard vs Lee Stange | Tenth | 24 out |
| Saturday, July 9 |
| » Defeated White Sox (38-45), 4-2 | Fenway Park (20-24) | 35-52 | Won 3 |
| » Starters: Gary Peters vs Bucky Brandon | Tenth | 23½ out |
| Sunday, July 10 |
| » Defeated White Sox (38-46), 8-4 | Fenway Park (21-24) | 36-52 | Won 4 |
| » Starters: Joe Horlen vs Jose Santiago | Tenth | 22 out |
| » Defeated White Sox (38-47), 10-6 | Fenway Park (22-24) | 37-52 | Won 5 |
| » Starters: John Buzhardt vs Dave Morehead | Tenth | 22 out |
| Thursday, July 14 |
| » Lost to Angels (47-39), 3-2 | Anaheim Stadium (1-4) | 37-53 | |
| » Starters: Dennis Bennett vs Marcelino Lopez | Ninth | 22 out |
| Friday, July 15 |
| » Lost to Angels (48-39), 4-2 | Anaheim Stadium (1-5) | 37-54 | Lost 2 |
| » Starters: Bucky Brandon vs George Brunet | Ninth | 22 out |
| Saturday, July 16 |
| » Defeated Angels (48-40), 7-1 | Anaheim Stadium (2-5) | 38-54 | |
| » Starters: Jose Santiago vs Dean Chance | Tenth | 22 out |
| Sunday, July 17 |
| » Lost to Athletics (41-48), 3-2 | Municipal Stadium (0-4) | 38-55 | |
| » Starters: Rollie Sheldon vs Jim Nash | Tenth | 22 out |
| » Defeated Athletics (41-49), 3-2 | Municipal Stadium (1-4) | 39-55 | |
| » Starters: Lee Stange vs Bill Stafford | Tenth | 22 out |
| Wednesday, July 20 |
| » Defeated Angels (49-43), 6-1 | Fenway Park (23-24) | 40-55 | Won 2 |
| » Starters: George Brunet vs Bucky Brandon | Ninth | 23½ out |
| » Lost to Angels (50-43), 1-0 | Fenway Park (23-25) | 40-56 | |
| » Starters: Dean Chance vs Dennis Bennett | Ninth | 23½ out |
| Thursday, July 21 |
| » Defeated Angels (50-44), 7-3 | Fenway Park (24-25) | 41-56 | |
| » Starters: Fred Newman vs Jose Santiago | Ninth | 23½ out |
| Friday, July 22 |
| » Defeated Twins (47-49), 6-5 | Fenway Park (25-25) | 42-56 | Won 2 |
| » Starters: Mudcat Grant vs Lee Stange | Ninth | 23½ out |
| Saturday, July 23 |
| » Lost to Twins (48-49), 10-4 | Fenway Park (25-26) | 42-57 | |
| » Starters: Jim Kaat vs Rollie Sheldon | Ninth | 24½ out |
| Sunday, July 24 |
| » Lost to Twins (49-49), 4-2 | Fenway Park (25-27) | 42-58 | Lost 2 |
| » Starters: Jim Perry vs Bucky Brandon | Tenth | 24½ out |
| Tuesday, July 26 |
| » Defeated Athletics (42-55), 8-5 | Fenway Park (26-27) | 43-58 | |
| » Starters: Lew Krausse vs Dennis Bennett | Tenth | 23½ out |
| Wednesday, July 27 |
| » Lost to Athletics (43-55), 14-2 | Fenway Park (26-28) | 43-59 | |
| » Starters: Jim Nash vs Jose Santiago | Tenth | 24½ out |
| Friday, July 29 |
| » Lost to Senators (46-59), 13-4 | Robert F. Kennedy Stadium (1-3) | 43-60 | Lost 2 |
| » Starters: Bucky Brandon vs Pete Richert | Tenth | 26 out |
| » Lost to Senators (47-59), 6-5 | Robert F. Kennedy Stadium (1-4) | 43-61 | Lost 3 |
| » Starters: Rollie Sheldon vs Phil Ortega | Tenth | 26 out |
| Saturday, July 30 |
| » Defeated Senators (47-60), 8-2 | Robert F. Kennedy Stadium (2-4) | 44-61 | |
| » Starters: Jose Santiago vs Mike McCormick | Tenth | 25 out |
| Sunday, July 31 |
| » Defeated Senators (47-61), 5-2 | Robert F. Kennedy Stadium (3-4) | 45-61 | Won 2 |
| » Starters: Dennis Bennett vs Jim Hannan | Tenth | 25 out |
| Monday, August 1 |
| » Lost to Twins (52-52), 6-2 | Metropolitan Stadium (2-3) | 45-62 | |
| » Starters: Lee Stange vs Mudcat Grant | Tenth | 25½ out |
| Tuesday, August 2 |
| » Lost to Twins (53-52), 7-3 | Metropolitan Stadium (2-4) | 45-63 | Lost 2 |
| » Starters: Bucky Brandon vs Jim Perry | Tenth | 26½ out |
| Future Red Sox Tim Wakefield is born in Melbourne, FL. |
| Wednesday, August 3 |
| » Lost to Twins (54-52), 7-2 | Metropolitan Stadium (2-5) | 45-64 | Lost 3 |
| » Starters: Rollie Sheldon vs Dave Boswell | Tenth | 26½ out |
| Thursday, August 4 |
| » Lost to Twins (55-52), 2-1 | Metropolitan Stadium (2-6) | 45-65 | Lost 4 |
| » Starters: Jose Santiago vs Jim Kaat | Tenth | 26½ out |
| Friday, August 5 |
| » Lost to Tigers (58-48), 2-0 | Tiger Stadium (1-5) | 45-66 | Lost 5 |
| » Starters: Dennis Bennett vs Earl Wilson | Tenth | 26½ out |
| Saturday, August 6 |
| » Defeated Tigers (58-49), 8-2 | Tiger Stadium (2-5) | 46-66 | |
| » Starters: Lee Stange vs Denny McLain | Tenth | 26½ out |
| Future Red Sox Stan Belinda is born in Huntingdon, PA. |
| Sunday, August 7 |
| » Lost to Tigers (59-49), 9-2 | Tiger Stadium (2-6) | 46-67 | |
| » Starters: Jim Lonborg vs Bill Monbouquette | Tenth | 26 out |
| » Defeated Tigers (59-50), 7-6 | Tiger Stadium (3-6) | 47-67 | |
| » Starters: Bucky Brandon vs Mickey Lolich | Tenth | 26 out |
| Monday, August 8 |
| » Defeated Indians (59-52), 3-1 | Fenway Park (27-28) | 48-67 | Won 2 |
| » Starters: Gary Bell vs Jose Santiago | Ninth | 25½ out |
| Tuesday, August 9 |
| » Lost to Indians (60-52), 5-0 | Fenway Park (27-29) | 48-68 | |
| » Starters: Steve Hargan vs Dennis Bennett | Tenth | 25½ out |
| Wednesday, August 10 |
| » Defeated Indians (60-53), 2-0 | Fenway Park (28-29) | 49-68 | |
| » Starters: Sam McDowell vs Lee Stange | Tenth | 25½ out |
| Thursday, August 11 |
| » Defeated Indians (60-54), 13-3 | Fenway Park (29-29) | 50-68 | Won 2 |
| » Starters: Sonny Siebert vs Jim Lonborg | Ninth | 25½ out |
| Friday, August 12 |
| » Defeated Tigers (61-52), 13-9 | Fenway Park (30-29) | 51-68 | Won 3 |
| » Starters: Bill Monbouquette vs Bucky Brandon | Tenth | 25 out |
| Saturday, August 13 |
| » Lost to Tigers (62-52), 13-1 | Fenway Park (30-30) | 51-69 | |
| » Starters: Earl Wilson vs Jose Santiago | Ninth | 26 out |
| Sunday, August 14 |
| » Defeated Tigers (62-53), 8-5 | Fenway Park (31-30) | 52-69 | |
| » Starters: Denny McLain vs Dennis Bennett | Eighth | 25½ out |
| » Defeated Tigers (62-54), 5-3 | Fenway Park (32-30) | 53-69 | Won 2 |
| » Starters: Joe Sparma vs Lee Stange | Eighth | 25½ out |
| Monday, August 15 |
| » Lost to Orioles (77-41), 4-2 | Fenway Park (32-31) | 53-70 | |
| » Starters: Dave McNally vs Jim Lonborg | Ninth | 26½ out |
| Tuesday, August 16 |
| » Lost to Orioles (78-41), 6-4 | Fenway Park (32-32) | 53-71 | Lost 2 |
| » Starters: Moe Drabowsky vs Bucky Brandon | Tenth | 27½ out |
| Future Red Sox Terry Shumpert is born in Paducah, KY. |
| Wednesday, August 17 |
| » Lost to Orioles (79-41), 8-4 | Fenway Park (32-33) | 53-72 | Lost 3 |
| » Starters: Jim Palmer vs Jose Santiago | Eighth | 28½ out |
| Thursday, August 18 |
| Future Red Sox Bob Zupcic is born in Pittsburgh, PA. |
| Friday, August 19 |
| » Lost to Twins (65-58), 2-1 | Fenway Park (32-34) | 53-73 | Lost 4 |
| » Starters: Jim Kaat vs Lee Stange | Ninth | 28½ out |
| Saturday, August 20 |
| » Lost to Twins (66-58), 4-2 | Fenway Park (32-35) | 53-74 | Lost 5 |
| » Starters: Jim Perry vs Dennis Bennett | Ninth | 29½ out |
| Sunday, August 21 |
| » Defeated Twins (66-59), 6-4 | Fenway Park (33-35) | 54-74 | |
| » Starters: Dave Boswell vs Jim Lonborg | Ninth | 28½ out |
| Wednesday, August 24 |
| » Lost to Athletics (55-71), 4-2 | Fenway Park (33-36) | 54-75 | |
| » Starters: Jim Nash vs Bucky Brandon | Ninth | 28½ out |
| » Lost to Athletics (56-71), 8-3 | Fenway Park (33-37) | 54-76 | Lost 2 |
| » Starters: Lew Krausse vs Jose Santiago | Ninth | 28½ out |
| Thursday, August 25 |
| » Defeated Athletics (56-72), 8-6 | Fenway Park (34-37) | 55-76 | |
| » Starters: Blue Moon Odom vs Dennis Bennett | Tenth | 28 out |
| » Defeated Athletics (56-73), 4-1 | Fenway Park (35-37) | 56-76 | Won 2 |
| » Starters: Paul Lindblad vs Hank Fischer | Tenth | 28 out |
| Friday, August 26 |
| » Lost to Orioles (82-45), 3-2 | Memorial Stadium (3-4) | 56-77 | |
| » Starters: Lee Stange vs John Miller | Ninth | 29 out |
| Saturday, August 27 |
| » Defeated Orioles (82-46), 3-2 | Memorial Stadium (4-4) | 57-77 | |
| » Starters: Jim Lonborg vs Frank Bertaina | Tenth | 28 out |
| Sunday, August 28 |
| » Defeated Orioles (82-47), 3-2 | Memorial Stadium (5-4) | 58-77 | Won 2 |
| » Starters: Bucky Brandon vs Jim Palmer | Tenth | 27 out |
| Monday, August 29 |
| » Defeated Angels (66-65), 4-3 | Anaheim Stadium (3-5) | 59-77 | Won 3 |
| » Starters: Jose Santiago vs George Brunet | Ninth | 26 out |
| Former Red Sox Al DeVormer dies in Grand Rapids, MI at the age of 76. |
| Tuesday, August 30 |
| » Defeated Angels (66-66), 7-6 | Anaheim Stadium (4-5) | 60-77 | Won 4 |
| » Starters: Dennis Bennett vs Jim Coates | Ninth | 25 out |
| Wednesday, August 31 |
| » Lost to Twins (72-63), 11-2 | Metropolitan Stadium (2-7) | 60-78 | |
| » Starters: Lee Stange vs Jim Kaat | Ninth | 26 out |
| Future Red Sox Jeff Frye is born in Oakland, CA. |
| Friday, September 2 |
| » Lost to Athletics (60-77), 5-1 | Municipal Stadium (1-5) | 60-79 | Lost 2 |
| » Starters: Hank Fischer vs Lew Krausse | Tenth | 25½ out |
| Saturday, September 3 |
| » Defeated Athletics (60-78), 7-0 | Municipal Stadium (2-5) | 61-79 | |
| » Starters: Jim Lonborg vs Catfish Hunter | Ninth | 25½ out |
| » Major-league debuts: Rick Monday (Athletics) |
| Sunday, September 4 |
| » Defeated Athletics (60-79), 3-0 | Municipal Stadium (3-5) | 62-79 | Won 2 |
| » Starters: Bucky Brandon vs Blue Moon Odom | Ninth | 26 out |
| » Lost to Athletics (61-79), 7-2 | Municipal Stadium (3-6) | 62-80 | |
| » Starters: Jose Santiago vs Gil Blanco | Ninth | 26 out |
| Monday, September 5 |
| » Defeated Indians (70-70), 5-1 | Cleveland Stadium (2-4) | 63-80 | |
| » Starters: Lee Stange vs Steve Hargan | Ninth | 27 out |
| » Lost to Indians (71-70), 3-1 | Cleveland Stadium (2-5) | 63-81 | |
| » Starters: Dennis Bennett vs Sonny Siebert | Ninth | 27 out |
| Tuesday, September 6 |
| » Lost to Indians (72-70), 6-2 | Cleveland Stadium (2-6) | 63-82 | Lost 2 |
| » Starters: Hank Fischer vs Gary Bell | Ninth | 28 out |
| Wednesday, September 7 |
| » Defeated Indians (72-71), 5-4 | Cleveland Stadium (3-6) | 64-82 | |
| » Starters: Jim Lonborg vs George Culver | Ninth | 28 out |
| » Major-league debuts: George Culver (Indians) |
| Friday, September 9 |
| » Lost to Yankees (63-81), 2-1 | Fenway Park (35-38) | 64-83 | |
| » Manager: Pete Runnels |
| » Starters: Fred Talbot vs Bucky Brandon | Tenth | 28 out |
| » Major-league debuts: Stan Bahnsen (Yankees) |
| Saturday, September 10 |
| » Lost to Yankees (64-81), 5-1 | Fenway Park (35-39) | 64-84 | Lost 2 |
| » Starters: Al Downing vs Jose Santiago | Tenth | 28 out |
| Sunday, September 11 |
| » Lost to Yankees (65-81), 4-2 | Fenway Park (35-40) | 64-85 | Lost 3 |
| » Starters: Jim Bouton vs Lee Stange | Tenth | 28 out |
| » Major-league debuts: John Miller (Yankees) |
| Tuesday, September 13 |
| » Defeated White Sox (76-71), 10-1 | Fenway Park (36-40) | 65-85 | |
| » Starters: Tommy John vs Jim Lonborg | Tenth | 27 out |
| Former Red Sox Ralph Comstock dies in Toledo, OH at the age of 76. |
| Wednesday, September 14 |
| » Defeated White Sox (76-72), 2-1 | |
