| Tuesday, January 25 |
| Future Oriole Richie Lewis is born in Muncie, IN. |
| Sunday, February 27 |
| Future Oriole Pete Smith is born in Abington, MA. |
| Wednesday, March 2 |
| Future Oriole Leo Gomez is born in Canovanas, P.R. |
| Thursday, March 3 |
| Future Oriole Francisco De la Rosa is born in La Romana, D.R. |
| Sunday, March 6 |
| Future Oriole Anthony Telford is born in San Jose, CA. |
| Thursday, March 10 |
| Future Oriole Mike Timlin is born in Midland, TX. |
| Monday, April 11 |
| Future Oriole Steve Scarsone is born in Anaheim, CA. |
| Tuesday, April 12 |
| » Defeated Red Sox (0-1), 5-4 | Fenway Park (1-0) | 1-0 | |
| » Starters: Steve Barber vs Earl Wilson | First | -- |
| » Major-league debuts: Guido Grilli and George Scott (Red Sox) Eddie Watt (Orioles) |
| Wednesday, April 13 |
| » Defeated Red Sox (0-2), 8-1 | Fenway Park (2-0) | 2-0 | Won 2 |
| » Starters: Jim Palmer vs Dave Morehead | First | -- |
| » Major-league debuts: Joe Foy and Pete Magrini (Red Sox) |
| Thursday, April 14 |
| Future Oriole Greg Myers is born in Riverside, CA. |
| Friday, April 15 |
| » Lost to Yankees (1-3), 3-2 | Memorial Stadium (0-1) | 2-1 | |
| » Starters: Fritz Peterson vs Wally Bunker | Fourth | 1½ out |
| » Major-league debuts: Fritz Peterson (Yankees) |
| Saturday, April 16 |
| » Defeated Yankees (1-4), 7-2 | Memorial Stadium (1-1) | 3-1 | |
| » Starters: Al Downing vs Dave McNally | Third | 1½ out |
| Sunday, April 17 |
| » Defeated Yankees (1-5), 5-4 | Memorial Stadium (2-1) | 4-1 | Won 2 |
| » Starters: Whitey Ford vs Steve Barber | Third | ½ out |
| Tuesday, April 19 |
| » Defeated Senators (1-4), 14-8 | Memorial Stadium (3-1) | 5-1 | Won 3 |
| » Starters: Phil Ortega vs Jim Palmer | Second | ½ out |
| Wednesday, April 20 |
| » Defeated Senators (1-5), 6-3 | Memorial Stadium (4-1) | 6-1 | Won 4 |
| » Starters: Pete Richert vs Wally Bunker | Second | ½ out |
| Saturday, April 23 |
| » Defeated Yankees (1-8), 4-3 | Yankee Stadium (1-0) | 7-1 | Won 5 |
| » Starters: Dave McNally vs Fritz Peterson | Second | ½ out |
| Sunday, April 24 |
| » Defeated Yankees (1-9), 2-1 | Yankee Stadium (2-0) | 8-1 | Won 6 |
| » Starters: Steve Barber vs Mel Stottlemyre | Second | 1 out |
| Monday, April 25 |
| Future Oriole Darren Holmes is born in Asheville, NC. |
| Tuesday, April 26 |
| » Defeated Angels (6-5), 7-3 | Memorial Stadium (5-1) | 9-1 | Won 7 |
| » Starters: Jim McGlothlin vs Jim Palmer | Second | ½ out |
| Thursday, April 28 |
| Future Oriole Jim Poole is born in Rochester, NY. |
| Friday, April 29 |
| » Defeated Tigers (10-5), 8-1 | Tiger Stadium (1-0) | 10-1 | Won 8 |
| » Starters: Wally Bunker vs Bill Monbouquette | First | -- |
| Saturday, April 30 |
| » Defeated Tigers (10-6), 3-2 | Tiger Stadium (2-0) | 11-1 | Won 9 |
| » Starters: Dave McNally vs Denny McLain | First | -- |
| Sunday, May 1 |
| » Defeated Tigers (10-7), 4-1 | Tiger Stadium (3-0) | 12-1 | Won 10 |
| » Starters: Steve Barber vs Joe Sparma | First | -- |
| Tuesday, May 3 |
| » Lost to Senators (5-10), 3-0 | Robert F. Kennedy Stadium (0-1) | 12-2 | |
| » Starters: Jim Palmer vs Phil Ortega | Second | ½ out |
| Wednesday, May 4 |
| » Lost to Senators (6-10), 3-2 | Robert F. Kennedy Stadium (0-2) | 12-3 | Lost 2 |
| » Starters: Wally Bunker vs Jim Duckworth | Second | 1½ out |
| Friday, May 6 |
| » Defeated Indians (14-2), 3-2 | Memorial Stadium (6-1) | 13-3 | |
| » Starters: Sam McDowell vs Dave McNally | Second | 1 out |
| Saturday, May 7 |
| » Lost to Indians (15-2), 6-3 | Memorial Stadium (6-2) | 13-4 | |
| » Starters: Gary Bell vs Steve Barber | Second | 2 out |
| Sunday, May 8 |
| » Defeated Indians (15-3), 8-2 | Memorial Stadium (7-2) | 14-4 | |
| » Starters: Sonny Siebert vs Jim Palmer | First | -- |
| » Defeated Indians (15-4), 8-3 | Memorial Stadium (8-2) | 15-4 | Won 2 |
| » Starters: Luis Tiant vs Wally Bunker | First | -- |
| Tuesday, May 10 |
| » Defeated White Sox (11-9), 3-2 | Memorial Stadium (9-2) | 16-4 | Won 3 |
| » Starters: Gary Peters vs John Miller | First | -- |
| Wednesday, May 11 |
| » Lost to White Sox (12-9), 3-2 | Memorial Stadium (9-3) | 16-5 | |
| » Starters: Tommy John vs Dave McNally | First | -- |
| » Major-league debuts: Gene Brabender (Orioles) |
| Future Oriole Trenidad Hubbard is born in Chicago, IL. |
| Thursday, May 12 |
| » Lost to White Sox (13-9), 5-3 | Memorial Stadium (9-4) | 16-6 | Lost 2 |
| » Starters: Bruce Howard vs Frank Bertaina | Second | 1 out |
| Friday, May 13 |
| » Lost to Indians (16-5), 4-3 | Cleveland Stadium (0-1) | 16-7 | Lost 3 |
| » Starters: Jim Palmer vs Sam McDowell | Second | 1 out |
| Saturday, May 14 |
| » Lost to Indians (17-5), 2-1 | Cleveland Stadium (0-2) | 16-8 | Lost 4 |
| » Starters: Wally Bunker vs Sonny Siebert | Second | 2 out |
| Sunday, May 15 |
| » Defeated Indians (17-6), 1-0 | Cleveland Stadium (1-2) | 17-8 | |
| » Starters: John Miller vs Gary Bell | Second | 2 out |
| » Lost to Indians (18-6), 2-1 | Cleveland Stadium (1-3) | 17-9 | |
| » Starters: Dave McNally vs Lee Stange | Second | 2 out |
| Tuesday, May 17 |
| » Defeated Red Sox (8-21), 8-6 | Memorial Stadium (10-4) | 18-9 | |
| » Starters: Jerry Stephenson vs Frank Bertaina | Second | 2 out |
| Wednesday, May 18 |
| » Lost to Red Sox (9-21), 2-1 | Memorial Stadium (10-5) | 18-10 | |
| » Starters: Earl Wilson vs Jim Palmer | Second | 2 out |
| Thursday, May 19 |
| » Lost to Red Sox (10-21), 3-1 | Memorial Stadium (10-6) | 18-11 | Lost 2 |
| » Starters: Dick Stigman vs Steve Barber | Second | 2 out |
| Friday, May 20 |
| » Defeated Tigers (17-12), 8-4 | Memorial Stadium (11-6) | 19-11 | |
| » Starters: Joe Sparma vs Wally Bunker | Second | 2½ out |
| » Lost to Tigers (18-12), 9-5 | Memorial Stadium (11-7) | 19-12 | |
| » Starters: Bill Monbouquette vs Dave McNally | Second | 2½ out |
| Saturday, May 21 |
| » Lost to Tigers (19-12), 7-5 | Memorial Stadium (11-8) | 19-13 | Lost 2 |
| » Starters: Denny McLain vs John Miller | Third | 2½ out |
| Sunday, May 22 |
| » Lost to Tigers (20-12), 3-2 | Memorial Stadium (11-9) | 19-14 | Lost 3 |
| » Starters: Mickey Lolich vs Frank Bertaina | Third | 4 out |
| Future Oriole Jose Mesa is born in Pueblo Viejo, D.R. |
| Tuesday, May 24 |
| » Defeated White Sox (15-18), 6-4 | Comiskey Park I (1-0) | 20-14 | |
| » Starters: Jim Palmer vs John Buzhardt | Third | 3½ out |
| Wednesday, May 25 |
| » Lost to White Sox (16-18), 3-2 | Comiskey Park I (1-1) | 20-15 | |
| » Starters: Steve Barber vs Tommy John | Third | 4½ out |
| Thursday, May 26 |
| » Defeated White Sox (16-19), 7-1 | Comiskey Park I (2-1) | 21-15 | |
| » Starters: Dave McNally vs Juan Pizarro | Second | 4½ out |
| Friday, May 27 |
| » Defeated Athletics (13-23), 4-2 | Municipal Stadium (1-0) | 22-15 | Won 2 |
| » Starters: Wally Bunker vs Rollie Sheldon | Second | 4½ out |
| Saturday, May 28 |
| » Defeated Athletics (13-24), 9-2 | Municipal Stadium (2-0) | 23-15 | Won 3 |
| » Starters: John Miller vs Ralph Terry | Second | 4½ out |
| Sunday, May 29 |
| » Lost to Athletics (14-24), 6-3 | Municipal Stadium (2-1) | 23-16 | |
| » Starters: Jim Palmer vs Catfish Hunter | Second | 4 out |
| Monday, May 30 |
| » Defeated Twins (19-20), 5-1 | Metropolitan Stadium (1-0) | 24-16 | |
| » Starters: Steve Barber vs Jim Merritt | Second | 3 out |
| » Lost to Twins (20-20), 7-4 | Metropolitan Stadium (1-1) | 24-17 | |
| » Starters: Frank Bertaina vs Dwight Siebler | Second | 3 out |
| Tuesday, May 31 |
| » Defeated Twins (20-21), 14-5 | Metropolitan Stadium (2-1) | 25-17 | |
| » Starters: Dave McNally vs Camilo Pascual | Second | 3 out |
| Wednesday, June 1 |
| » Defeated Angels (23-21), 9-7 | Anaheim Stadium (1-0) | 26-17 | Won 2 |
| » Starters: Wally Bunker vs Fred Newman | Second | 2 out |
| Thursday, June 2 |
| » Defeated Angels (23-22), 9-6 | Anaheim Stadium (2-0) | 27-17 | Won 3 |
| » Starters: John Miller vs Jack Sanford | Second | 1 out |
| Friday, June 3 |
| » Defeated Athletics (17-26), 3-2 | Memorial Stadium (12-9) | 28-17 | Won 4 |
| » Starters: Catfish Hunter vs Jim Palmer | Second | 1 out |
| Saturday, June 4 |
| » Defeated Athletics (17-27), 9-0 | Memorial Stadium (13-9) | 29-17 | Won 5 |
| » Starters: Chuck Dobson vs Steve Barber | Second | ½ out |
| » Defeated Athletics (17-28), 6-5 | Memorial Stadium (14-9) | 30-17 | Won 6 |
| » Starters: Fred Talbot vs Dave McNally | Second | ½ out |
| Sunday, June 5 |
| » Lost to Athletics (18-28), 9-4 | Memorial Stadium (14-10) | 30-18 | |
| » Starters: Rollie Sheldon vs Wally Bunker | Second | ½ out |
| Monday, June 6 |
| » Lost to Senators (23-28), 5-3 | Robert F. Kennedy Stadium (0-3) | 30-19 | Lost 2 |
| » Starters: John Miller vs Phil Ortega | Second | 1 out |
| Tuesday, June 7 |
| » Defeated Senators (23-29), 6-5 | Memorial Stadium (15-10) | 31-19 | |
| » Starters: Mike McCormick vs Frank Bertaina | Second | 1 out |
| Future Oriole Heathcliff Slocumb is born in Jamaica, NY. |
| Wednesday, June 8 |
| » Defeated Senators (23-30), 6-5 | Memorial Stadium (16-10) | 32-19 | Won 2 |
| » Starters: Pete Richert vs Jim Palmer | First | -- |
| » Defeated Senators (23-31), 8-7 | Memorial Stadium (17-10) | 33-19 | Won 3 |
| » Starters: Jim Hannan vs Steve Barber | First | -- |
| Thursday, June 9 |
| » Defeated Senators (23-32), 4-2 | Memorial Stadium (18-10) | 34-19 | Won 4 |
| » Starters: Diego Segui vs Dave McNally | First | -- |
| Friday, June 10 |
| » Defeated Red Sox (19-34), 9-2 | Memorial Stadium (19-10) | 35-19 | Won 5 |
| » Starters: Lee Stange vs Wally Bunker | First | -- |
| Saturday, June 11 |
| » Lost to Red Sox (20-34), 8-2 | Memorial Stadium (19-11) | 35-20 | |
| » Starters: Jim Lonborg vs John Miller | Second | 2 out |
| Sunday, June 12 |
| » Defeated Red Sox (20-35), 8-1 | Memorial Stadium (20-11) | 36-20 | |
| » Starters: Earl Wilson vs Steve Barber | Second | 2 out |
| Monday, June 13 |
| » Defeated Yankees (24-29), 8-0 | Memorial Stadium (21-11) | 37-20 | Won 2 |
| » Starters: Al Downing vs Jim Palmer | Second | 2½ out |
| Tuesday, June 14 |
| » Defeated Yankees (24-30), 2-1 | Memorial Stadium (22-11) | 38-20 | Won 3 |
| » Starters: Jim Bouton vs Dave McNally | First | -- |
| Wednesday, June 15 |
| » Defeated Senators (24-37), 6-4 | Robert F. Kennedy Stadium (1-3) | 39-20 | Won 4 |
| » Starters: Wally Bunker vs Dick Bosman | First | -- |
| Thursday, June 16 |
| » Lost to Senators (25-37), 2-1 | Robert F. Kennedy Stadium (1-4) | 39-21 | |
| » Starters: Frank Bertaina vs Pete Richert | First | -- |
| Friday, June 17 |
| » Defeated Red Sox (21-39), 5-3 | Fenway Park (3-0) | 40-21 | |
| » Starters: Steve Barber vs Jim Lonborg | First | -- |
| Saturday, June 18 |
| » Defeated Red Sox (21-40), 16-6 | Fenway Park (4-0) | 41-21 | Won 2 |
| » Starters: Jim Palmer vs Bob Sadowski | First | -- |
| Sunday, June 19 |
| » Defeated Red Sox (21-41), 5-3 | Fenway Park (5-0) | 42-21 | Won 3 |
| » Starters: Dave McNally vs Lee Stange | First | -- |
| » Lost to Red Sox (22-41), 5-2 | Fenway Park (5-1) | 42-22 | |
| » Starters: John Miller vs Jose Santiago | First | -- |
| Tuesday, June 21 |
| » Defeated Yankees (26-34), 7-5 | Yankee Stadium (3-0) | 43-22 | |
| » Starters: Wally Bunker vs Mel Stottlemyre | First | -- |
| » Lost to Yankees (27-34), 8-3 | Yankee Stadium (3-1) | 43-23 | |
| » Starters: Frank Bertaina vs Fritz Peterson | First | -- |
| Wednesday, June 22 |
| » Defeated Yankees (27-35), 3-0 | Yankee Stadium (4-1) | 44-23 | |
| » Starters: Steve Barber vs Fred Talbot | First | -- |
| Thursday, June 23 |
| » Defeated Yankees (27-36), 5-2 | Yankee Stadium (5-1) | 45-23 | Won 2 |
| » Starters: Jim Palmer vs Al Downing | First | -- |
| Friday, June 24 |
| » Lost to Angels (38-31), 5-4 | Anaheim Stadium (2-1) | 45-24 | |
| » Starters: Dave McNally vs Clyde Wright | First | -- |
| Saturday, June 25 |
| » Defeated Angels (38-32), 1-0 | Anaheim Stadium (3-1) | 46-24 | |
| » Starters: Wally Bunker vs George Brunet | First | -- |
| Sunday, June 26 |
| » Defeated Angels (38-33), 12-7 | Anaheim Stadium (4-1) | 47-24 | Won 2 |
| » Starters: Frank Bertaina vs Dean Chance | First | -- |
| Monday, June 27 |
| » Defeated Angels (38-34), 4-1 | Anaheim Stadium (5-1) | 48-24 | Won 3 |
| » Starters: Steve Barber vs Marcelino Lopez | First | -- |
| Future Oriole Jeff Conine is born in Tacoma, WA. |
| Tuesday, June 28 |
| » Lost to Athletics (31-40), 4-3 | Municipal Stadium (2-2) | 48-25 | |
| » Starters: Jim Palmer vs Chuck Dobson | First | -- |
| Wednesday, June 29 |
| » Defeated Athletics (31-41), 5-2 | Municipal Stadium (3-2) | 49-25 | |
| » Starters: Dave McNally vs Lew Krausse | First | -- |
| Thursday, June 30 |
| » Defeated Athletics (31-42), 11-3 | Municipal Stadium (4-2) | 50-25 | Won 2 |
| » Starters: Wally Bunker vs Ralph Terry | First | -- |
| Friday, July 1 |
| » Defeated Twins (35-39), 4-1 | Memorial Stadium (23-11) | 51-25 | Won 3 |
| » Starters: Jim Kaat vs Steve Barber | First | -- |
| » Defeated Twins (35-40), 2-0 | Memorial Stadium (24-11) | 52-25 | Won 4 |
| » Starters: Jim Merritt vs Bill Short | First | -- |
| Saturday, July 2 |
| » Defeated Twins (35-41), 6-5 | Memorial Stadium (25-11) | 53-25 | Won 5 |
| » Starters: Dave Boswell vs John Miller | First | -- |
| » Defeated Twins (35-42), 3-2 | Memorial Stadium (26-11) | 54-25 | Won 6 |
| » Starters: Mudcat Grant vs Eddie Watt | First | -- |
| Sunday, July 3 |
| » Defeated Twins (35-43), 4-2 | Memorial Stadium (27-11) | 55-25 | Won 7 |
| » Starters: Jim Perry vs Dave McNally | First | -- |
| Monday, July 4 |
| » Lost to Athletics (35-44), 9-6 | Memorial Stadium (27-12) | 55-26 | |
| » Starters: Catfish Hunter vs Gene Brabender | First | -- |
| Wednesday, July 6 |
| » Defeated Athletics (35-45), 11-0 | Memorial Stadium (28-12) | 56-26 | |
| » Starters: Bill Stafford vs Steve Barber | First | -- |
| » Lost to Athletics (36-45), 9-8 | Memorial Stadium (28-13) | 56-27 | |
| » Starters: Paul Lindblad vs Wally Bunker | First | -- |
| Friday, July 8 |
| » Defeated Angels (44-38), 2-1 | Memorial Stadium (29-13) | 57-27 | |
| » Starters: Marcelino Lopez vs Bill Short | First | -- |
| Saturday, July 9 |
| » Defeated Angels (44-39), 10-2 | Memorial Stadium (30-13) | 58-27 | Won 2 |
| » Starters: Dean Chance vs Jim Palmer | First | -- |
| » Lost to Angels (45-39), 2-1 | Memorial Stadium (30-14) | 58-28 | |
| » Starters: Clyde Wright vs Dave McNally | First | -- |
| Sunday, July 10 |
| » Lost to Angels (46-39), 4-0 | Memorial Stadium (30-15) | 58-29 | Lost 2 |
| » Starters: George Brunet vs Steve Barber | First | -- |
| Thursday, July 14 |
| » Lost to Tigers (49-35), 4-3 | Tiger Stadium (3-1) | 58-30 | Lost 3 |
| » Starters: Steve Barber vs Earl Wilson | First | -- |
| Friday, July 15 |
| » Lost to Tigers (50-35), 8-5 | Tiger Stadium (3-2) | 58-31 | Lost 4 |
| » Starters: Wally Bunker vs Dave Wickersham | First | -- |
| Saturday, July 16 |
| » Defeated Tigers (50-36), 8-2 | Tiger Stadium (4-2) | 59-31 | |
| » Starters: Dave McNally vs Denny McLain | First | -- |
| Sunday, July 17 |
| » Lost to White Sox (42-47), 5-1 | Comiskey Park I (2-2) | 59-32 | |
| » Starters: Bill Short vs Gary Peters | First | -- |
| » Defeated White Sox (42-48), 3-2 | Comiskey Park I (3-2) | 60-32 | |
| » Starters: Jim Palmer vs Jack Lamabe | First | -- |
| Monday, July 18 |
| » Defeated White Sox (42-49), 5-3 | Comiskey Park I (4-2) | 61-32 | Won 2 |
| » Starters: John Miller vs Juan Pizarro | First | -- |
| Tuesday, July 19 |
| » Defeated Tigers (50-39), 13-3 | Memorial Stadium (31-15) | 62-32 | Won 3 |
| » Starters: Earl Wilson vs Eddie Watt | First | -- |
| Future Oriole David Segui is born in Kansas City, KS. |
| Wednesday, July 20 |
| » Defeated Tigers (50-40), 10-7 | Memorial Stadium (32-15) | 63-32 | Won 4 |
| » Starters: Denny McLain vs Wally Bunker | First | -- |
| Thursday, July 21 |
| » Defeated Tigers (50-41), 6-4 | Memorial Stadium (33-15) | 64-32 | Won 5 |
| » Starters: Bill Monbouquette vs Dave McNally | First | -- |
| Friday, July 22 |
| » Defeated White Sox (45-50), 3-1 | Memorial Stadium (34-15) | 65-32 | Won 6 |
| » Starters: Gary Peters vs Jim Palmer | First | -- |
| Saturday, July 23 |
| » Defeated White Sox (45-51), 5-4 | Memorial Stadium (35-15) | 66-32 | Won 7 |
| » Starters: Tommy John vs Bill Short | First | -- |
| Sunday, July 24 |
| » Lost to White Sox (46-51), 4-0 | Memorial Stadium (35-16) | 66-33 | |
| » Starters: Bruce Howard vs Eddie Watt | First | -- |
| Tuesday, July 26 |
| » Lost to Indians (53-45), 7-4 | Memorial Stadium (35-17) | 66-34 | Lost 2 |
| » Starters: Gary Bell vs Steve Barber | First | -- |
| Wednesday, July 27 |
| » Defeated Indians (53-46), 7-1 | Memorial Stadium (36-17) | 67-34 | |
| » Starters: John O'Donoghue vs Dave McNally | First | -- |
| » Major-league debuts: Larry Haney (Orioles) |
| Friday, July 29 |
| » Defeated Twins (50-51), 3-0 | Metropolitan Stadium (3-1) | 68-34 | Won 2 |
| » Starters: Jim Palmer vs Jim Merritt | First | -- |
| Saturday, July 30 |
| » Lost to Twins (51-51), 7-0 | Metropolitan Stadium (3-2) | 68-35 | |
| » Starters: Bill Short vs Dave Boswell | First | -- |
| Sunday, July 31 |
| » Defeated Twins (51-52), 4-0 | Metropolitan Stadium (4-2) | 69-35 | |
| » Starters: Eddie Watt vs Jim Kaat | First | -- |
| Tuesday, August 2 |
| » Defeated Indians (54-49), 8-6 | Cleveland Stadium (2-3) | 70-35 | Won 2 |
| » Starters: Dave McNally vs Sam McDowell | First | -- |
| Wednesday, August 3 |
| » Lost to Indians (55-49), 9-6 | Cleveland Stadium (2-4) | 70-36 | |
| » Starters: Jim Palmer vs Sonny Siebert | First | -- |
| Thursday, August 4 |
| » Lost to Indians (56-49), 3-1 | Cleveland Stadium (2-5) | 70-37 | Lost 2 |
| » Starters: Bill Short vs Gary Bell | First | -- |
| Friday, August 5 |
| » Lost to Senators (50-63), 4-2 | Memorial Stadium (36-18) | 70-38 | Lost 3 |
| » Starters: Jim Hannan vs Eddie Watt | First | -- |
| Saturday, August 6 |
| » Defeated Senators (50-64), 4-0 | Memorial Stadium (37-18) | 71-38 | |
| » Starters: Barry Moore vs Dave McNally | First | -- |
| Sunday, August 7 |
| » Lost to Senators (51-64), 6-2 | Robert F. Kennedy Stadium (1-5) | 71-39 | |
| » Starters: John Miller vs Pete Richert | First | -- |
| Tuesday, August 9 |
| » Lost to Yankees (51-61), 4-1 | Yankee Stadium (5-2) | 71-40 | Lost 2 |
| » Starters: Jim Palmer vs Fritz Peterson | First | -- |
| Wednesday, August 10 |
| » Defeated Yankees (51-62), 9-4 | Yankee Stadium (6-2) | 72-40 | |
| » Starters: Eddie Watt vs Fred Talbot | First | -- |
| Thursday, August 11 |
| » Defeated Yankees (51-63), 6-5 | Yankee Stadium (7-2) | 73-40 | Won 2 |
| » Starters: Dave McNally vs Mel Stottlemyre | First | -- |
| Friday, August 12 |
| » Defeated Senators (52-67), 2-1 | Robert F. Kennedy Stadium (2-5) | 74-40 | Won 3 |
| » Starters: Moe Drabowsky vs Pete Richert | First | -- |
| » Lost to Senators (53-67), 4-1 | Robert F. Kennedy Stadium (2-6) | 74-41 | |
| » Starters: John Miller vs Barry Moore | First | -- |
| Saturday, August 13 |
| » Defeated Senators (53-68), 5-2 | Memorial Stadium (38-18) | 75-41 | |
| » Starters: Phil Ortega vs Jim Palmer | First | -- |
| Sunday, August 14 |
| » Defeated Senators (53-69), 6-0 | Robert F. Kennedy Stadium (3-6) | 76-41 | Won 2 |
| » Starters: Eddie Watt vs Frank Kreutzer | First | -- |
| Monday, August 15 |
| » Defeated Red Sox (53-70), 4-2 | Fenway Park (6-1) | 77-41 | Won 3 |
| » Starters: Dave McNally vs Jim Lonborg | First | -- |
| Tuesday, August 16 |
| » Defeated Red Sox (53-71), 6-4 | Fenway Park (7-1) | 78-41 | Won 4 |
| » Starters: Moe Drabowsky vs Bucky Brandon | First | -- |
| Wednesday, August 17 |
| » Defeated Red Sox (53-72), 8-4 | Fenway Park (8-1) | 79-41 | Won 5 |
| » Starters: Jim Palmer vs Jose Santiago | First | -- |
| Friday, August 19 |
| » Lost to Tigers (66-54), 10-4 | Tiger Stadium (4-3) | 79-42 | |
| » Starters: Eddie Watt vs Mickey Lolich | First | -- |
| Saturday, August 20 |
| » Defeated Tigers (66-55), 8-3 | Tiger Stadium (5-3) | 80-42 | |
| » Starters: Dave McNally vs Denny McLain | First | -- |
| Sunday, August 21 |
| » Lost to Tigers (67-55), 9-4 | Tiger Stadium (5-4) | 80-43 | |
| » Starters: Moe Drabowsky vs Earl Wilson | First | -- |
| Tuesday, August 23 |
| » Lost to Indians (67-59), 2-1 | Memorial Stadium (38-19) | 80-44 | Lost 2 |
| » Starters: Sam McDowell vs Jim Palmer | First | -- |
| Wednesday, August 24 |
| » Lost to Indians (68-59), 10-4 | Memorial Stadium (38-20) | 80-45 | Lost 3 |
| » Starters: Sonny Siebert vs Eddie Watt | First | -- |
| Thursday, August 25 |
| » Defeated Indians (68-60), 4-3 | Memorial Stadium (39-20) | 81-45 | |
| » Starters: Gary Bell vs Dave McNally | First | -- |
| Future Oriole Albert Belle is born in Shreveport, LA. |
| Friday, August 26 |
| » Defeated Red Sox (56-77), 3-2 | Memorial Stadium (40-20) | 82-45 | Won 2 |
| » Starters: Lee Stange vs John Miller | First | -- |
| Saturday, August 27 |
| » Lost to Red Sox (57-77), 3-2 | Memorial Stadium (40-21) | 82-46 | |
| » Starters: Jim Lonborg vs Frank Bertaina | First | -- |
| Sunday, August 28 |
| » Lost to Red Sox (58-77), 3-2 | Memorial Stadium (40-22) | 82-47 | Lost 2 |
| » Starters: Bucky Brandon vs Jim Palmer | First | -- |
| Monday, August 29 |
| » Lost to Tigers (70-59), 6-3 | Memorial Stadium (40-23) | 82-48 | Lost 3 |
| » Starters: Denny McLain vs Dave McNally | First | -- |
| Tuesday, August 30 |
| » Lost to Tigers (71-59), 5-4 | Memorial Stadium (40-24) | 82-49 | Lost 4 |
| » Starters: Earl Wilson vs Eddie Watt | First | -- |
| Wednesday, August 31 |
| » Defeated Indians (69-65), 5-1 | Cleveland Stadium (3-5) | 83-49 | |
| » Starters: John Miller vs Sam McDowell | First | -- |
| Thursday, September 1 |
| » Lost to Indians (70-65), 4-1 | Cleveland Stadium (3-6) | 83-50 | |
| » Starters: Jim Palmer vs Sonny Siebert | First | -- |
| Friday, September 2 |
| » Lost to White Sox (72-66), 9-8 | Comiskey Park I (4-3) | 83-51 | Lost 2 |
| » Starters: Dave McNally vs Tommy John | First | -- |
| Saturday, September 3 |
| » Defeated White Sox (72-67), 4-1 | Comiskey Park I (5-3) | 84-51 | |
| » Starters: Wally Bunker vs Jack Lamabe | First | -- |
| Sunday, September 4 |
| » Defeated White Sox (72-68), 8-5 | Comiskey Park I (6-3) | 85-51 | Won 2 |
| » Starters: Eddie Watt vs Gary Peters | First | -- |
| Monday, September 5 |
| » Defeated Yankees (62-78), 5-4 | Memorial Stadium (41-24) | 86-51 | Won 3 |
| » Starters: Fritz Peterson vs John Miller | First | -- |
| » Defeated Yankees (62-79), 7-4 | Memorial Stadium (42-24) | 87-51 | Won 4 |
| » Starters: Al Downing vs Jim Palmer | First | -- |
| Tuesday, September 6 |
| » Defeated Yankees (62-80), 4-1 | Memorial Stadium (43-24) | 88-51 | Won 5 |
| » Starters: Jim Bouton vs Dave McNally | First | -- |
| Wednesday, September 7 |
| » Defeated Yankees (62-81), 3-2 | Memorial Stadium (44-24) | 89-51 | Won 6 |
| » Starters: Mel Stottlemyre vs Wally Bunker | First | -- |
| Friday, September 9 |
| » Lost to Twins (78-65), 6-1 | Metropolitan Stadium (4-3) | 89-52 | |
| » Starters: Eddie Watt vs Jim Kaat | First | -- |
| Saturday, September 10 |
| » Lost to Twins (79-65), 7-2 | Metropolitan Stadium (4-4) | 89-53 | Lost 2 |
| » Starters: John Miller vs Jim Merritt | First | -- |
| Sunday, September 11 |
| » Lost to Twins (80-65), 11-6 | Metropolitan Stadium (4-5) | 89-54 | Lost 3 |
| » Starters: Dave McNally vs Mudcat Grant | First | -- |
| » Major-league debuts: Ron Clark (Twins) |
| Monday, September 12 |
| » Lost to Angels (73-71), 6-5 | Memorial Stadium (44-25) | 89-55 | Lost 4 |
| » Starters: George Brunet vs Wally Bunker | First | -- |
| Thursday, September 15 |
| » Defeated Angels (73-72), 2-0 | Memorial Stadium (45-25) | 90-55 | |
| » Starters: Dean Chance vs Tom Phoebus | First | -- |
| » Defeated Angels (73-73), 4-3 | Memorial Stadium (46-25) | 91-55 | Won 2 |
| » Starters: Marcelino Lopez vs Eddie Watt | First | -- |
| » Major-league debuts: Tom Phoebus (Orioles) |
| Friday, September 16 |
| » Lost to White Sox (77-73), 4-0 | Memorial Stadium (46-26) | 91-56 | |
| » Starters: Joe Horlen vs Dave McNally | First | -- |
| » Major-league debuts: Mike Epstein (Orioles) |
| Saturday, September 17 |
| » Lost to White Sox (78-73), 3-1 | Memorial Stadium (46-27) | 91-57 | Lost 2 |
| » Starters: Tommy John vs Jim Palmer | First | -- |
| Sunday, September 18 |
| » Lost to White Sox (79-73), 4-3 | Memorial Stadium (46-28) | 91-58 | Lost 3 |
| » Starters: Bruce Howard vs Wally Bunker | First | -- |
| Monday, September 19 |
| » Defeated Angels (74-76), 11-9 | Memorial Stadium (47-28) | 92-58 | |
| » Starters: Marcelino Lopez vs Steve Barber | First | -- |
| Tuesday, September 20 |
| » Defeated Athletics (70-82), 4-0 | Municipal Stadium (5-2) | 93-58 | Won 2 |
| » Starters: Tom Phoebus vs Catfish Hunter | First | -- |
| Wednesday, September 21 |
| » Defeated Athletics (70-83), 10-8 | Municipal Stadium (6-2) | 94-58 | Won 3 |
| » Starters: Dave McNally vs Jim Nash | First | -- |
| Thursday, September 22 |
| » Defeated Athletics (70-84), 6-1 | Municipal Stadium (7-2) | 95-58 | Won 4 |
| » Starters: Jim Palmer vs Lew Krausse | First | -- |
| Friday, September 23 |
| » Lost to Angels (76-78), 2-0 | Anaheim Stadium (5-2) | 95-59 | |
| » Starters: Steve Barber vs Marcelino Lopez | First | -- |
| Future Oriole Pete Harnisch is born in Commack, NY. |
| Saturday, September 24 |
| » Defeated Angels (76-79), 6-3 | Anaheim Stadium (6-2) | 96-59 | |
| » Starters: Wally Bunker vs Clyde Wright | First | -- |
| Sunday, September 25 |
| » Lost to Angels (77-79), 6-1 | Anaheim Stadium (6-3) | 96-60 | |
| » Starters: Tom Phoebus vs Dean Chance | First | -- |
| Friday, September 30 |
| » Lost to Twins (87-72), 10-7 | Memorial Stadium (47-29) | 96-61 | Lost 2 |
| » Starters: Mudcat Grant vs Dave McNally | First | -- |
| » Lost to Twins (88-72), 8-2 | Memorial Stadium (47-30) | 96-62 | Lost 3 |
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