| Sunday, January 16 |
| Future Indian Jack McDowell is born in Van Nuys, CA. |
| Saturday, January 29 |
| Former Indian Homer Summa dies in Los Angeles, CA at the age of 68. |
| Monday, January 31 |
| Former Indian Pat Donahue dies in Springfield, OH at the age of 82. |
| Sunday, February 13 |
| Future Indian Jerry Browne is born in Christiansted, V.I. |
| Monday, March 7 |
| Future Indian Mauro Gozzo is born in New Britain, CT. |
| Friday, March 11 |
| Future Indian Steve Reed is born in Los Angeles, CA. |
| Monday, April 11 |
| » Defeated Senators (0-1), 5-2 | Robert F. Kennedy Stadium (1-0) | 1-0 | |
| » Starters: Sam McDowell vs Pete Richert | First | -- |
| Thursday, April 14 |
| Future Indian David Justice is born in Cincinnati, OH. |
| Friday, April 15 |
| » Defeated Red Sox (0-3), 8-7 | Cleveland Stadium (1-0) | 2-0 | Won 2 |
| » Starters: Jerry Stephenson vs Sam McDowell | Second | 1 out |
| Saturday, April 16 |
| » Defeated Red Sox (0-4), 3-2 | Cleveland Stadium (2-0) | 3-0 | Won 3 |
| » Starters: Dick Stigman vs Gary Bell | Second | 1 out |
| Sunday, April 17 |
| » Defeated Red Sox (0-5), 6-0 | Cleveland Stadium (3-0) | 4-0 | Won 4 |
| » Starters: Earl Wilson vs Luis Tiant | First | -- |
| Tuesday, April 19 |
| » Defeated Yankees (1-6), 3-1 | Cleveland Stadium (4-0) | 5-0 | Won 5 |
| » Starters: Mel Stottlemyre vs Sam McDowell | First | -- |
| Wednesday, April 20 |
| » Defeated Yankees (1-7), 4-2 | Cleveland Stadium (5-0) | 6-0 | Won 6 |
| » Starters: Bob Friend vs Sonny Siebert | First | -- |
| Future Indian Tony Perezchica is born in Mexicali, Mexico. |
| Saturday, April 23 |
| » Defeated Red Sox (2-7), 5-4 | Fenway Park (1-0) | 7-0 | Won 7 |
| » Starters: Gary Bell vs Dick Stigman | First | -- |
| Monday, April 25 |
| » Defeated Athletics (2-7), 2-0 | Cleveland Stadium (6-0) | 8-0 | Won 8 |
| » Starters: Rollie Sheldon vs Sam McDowell | First | -- |
| Tuesday, April 26 |
| » Defeated Athletics (2-8), 4-0 | Cleveland Stadium (7-0) | 9-0 | Won 9 |
| » Starters: Chuck Dobson vs Luis Tiant | First | -- |
| Thursday, April 28 |
| » Defeated Angels (6-6), 2-1 | Cleveland Stadium (8-0) | 10-0 | Won 10 |
| » Starters: Marcelino Lopez vs Sonny Siebert | First | -- |
| Future Indian Jim Poole is born in Rochester, NY. |
| Friday, April 29 |
| » Lost to White Sox (10-3), 4-1 | Cleveland Stadium (8-1) | 10-1 | |
| » Starters: Gary Peters vs Gary Bell | First | -- |
| Sunday, May 1 |
| » Defeated White Sox (10-4), 1-0 | Cleveland Stadium (9-1) | 11-1 | |
| » Starters: Tommy John vs Sam McDowell | Second | ½ out |
| Tuesday, May 3 |
| » Defeated Yankees (4-13), 1-0 | Yankee Stadium (1-0) | 12-1 | Won 2 |
| » Starters: Luis Tiant vs Al Downing | First | -- |
| Wednesday, May 4 |
| » Defeated Yankees (4-14), 2-1 | Yankee Stadium (2-0) | 13-1 | Won 3 |
| » Starters: Sonny Siebert vs Mel Stottlemyre | First | -- |
| Thursday, May 5 |
| » Defeated Yankees (4-15), 4-0 | Yankee Stadium (3-0) | 14-1 | Won 4 |
| » Starters: John O'Donoghue vs Bob Friend | First | -- |
| Friday, May 6 |
| » Lost to Orioles (13-3), 3-2 | Memorial Stadium (0-1) | 14-2 | |
| » Starters: Sam McDowell vs Dave McNally | First | -- |
| Saturday, May 7 |
| » Defeated Orioles (13-4), 6-3 | Memorial Stadium (1-1) | 15-2 | |
| » Starters: Gary Bell vs Steve Barber | First | -- |
| Sunday, May 8 |
| » Lost to Orioles (14-4), 8-2 | Memorial Stadium (1-2) | 15-3 | |
| » Starters: Sonny Siebert vs Jim Palmer | First | -- |
| » Lost to Orioles (15-4), 8-3 | Memorial Stadium (1-3) | 15-4 | Lost 2 |
| » Starters: Luis Tiant vs Wally Bunker | First | -- |
| Tuesday, May 10 |
| » Lost to Tigers (14-9), 3-2 | Cleveland Stadium (9-2) | 15-5 | Lost 3 |
| » Starters: Mickey Lolich vs Gary Bell | Second | 1 out |
| Wednesday, May 11 |
| Future Indian Trenidad Hubbard is born in Chicago, IL. |
| Friday, May 13 |
| » Defeated Orioles (16-7), 4-3 | Cleveland Stadium (10-2) | 16-5 | |
| » Starters: Jim Palmer vs Sam McDowell | First | -- |
| Future Indian Chris Nichting is born in Cincinnati, OH. |
| Saturday, May 14 |
| » Defeated Orioles (16-8), 2-1 | Cleveland Stadium (11-2) | 17-5 | Won 2 |
| » Starters: Wally Bunker vs Sonny Siebert | First | -- |
| Sunday, May 15 |
| » Lost to Orioles (17-8), 1-0 | Cleveland Stadium (11-3) | 17-6 | |
| » Starters: John Miller vs Gary Bell | First | -- |
| » Defeated Orioles (17-9), 2-1 | Cleveland Stadium (12-3) | 18-6 | |
| » Starters: Dave McNally vs Lee Stange | First | -- |
| Tuesday, May 17 |
| » Defeated Senators (10-18), 3-2 | Cleveland Stadium (13-3) | 19-6 | Won 2 |
| » Starters: Diego Segui vs Sam McDowell | First | -- |
| Wednesday, May 18 |
| » Lost to Senators (11-18), 4-3 | Cleveland Stadium (13-4) | 19-7 | |
| » Starters: Pete Richert vs Sonny Siebert | First | -- |
| Thursday, May 19 |
| » Lost to Senators (12-18), 7-2 | Cleveland Stadium (13-5) | 19-8 | Lost 2 |
| » Starters: Mike McCormick vs Luis Tiant | First | -- |
| Friday, May 20 |
| » Defeated White Sox (14-15), 3-2 | Comiskey Park I (1-0) | 20-8 | |
| » Starters: Gary Bell vs Tommy John | First | -- |
| Saturday, May 21 |
| » Lost to White Sox (15-15), 7-2 | Comiskey Park I (1-1) | 20-9 | |
| » Starters: Sam McDowell vs Juan Pizarro | First | -- |
| Sunday, May 22 |
| » Defeated White Sox (15-16), 3-2 | Comiskey Park I (2-1) | 21-9 | |
| » Starters: Sonny Siebert vs Gary Peters | First | -- |
| » Defeated White Sox (15-17), 4-1 | Comiskey Park I (3-1) | 22-9 | Won 2 |
| » Starters: John O'Donoghue vs Bruce Howard | First | -- |
| Future Indian Jose Mesa is born in Pueblo Viejo, D.R. |
| Tuesday, May 24 |
| » Lost to Tigers (21-12), 7-6 | Tiger Stadium (0-1) | 22-10 | |
| » Starters: Gary Bell vs Joe Sparma | First | -- |
| » Defeated Tigers (21-13), 2-0 | Tiger Stadium (1-1) | 23-10 | |
| » Starters: Luis Tiant vs Hank Aguirre | First | -- |
| Wednesday, May 25 |
| » Defeated Tigers (21-14), 13-2 | Tiger Stadium (2-1) | 24-10 | Won 2 |
| » Starters: Sam McDowell vs Denny McLain | First | -- |
| Thursday, May 26 |
| » Defeated Tigers (21-15), 8-4 | Tiger Stadium (3-1) | 25-10 | Won 3 |
| » Starters: Sonny Siebert vs Mickey Lolich | First | -- |
| Friday, May 27 |
| » Defeated Twins (17-18), 5-4 | Cleveland Stadium (14-5) | 26-10 | Won 4 |
| » Starters: Camilo Pascual vs John O'Donoghue | First | -- |
| Saturday, May 28 |
| » Defeated Twins (17-19), 2-1 | Cleveland Stadium (15-5) | 27-10 | Won 5 |
| » Starters: Dave Boswell vs Gary Bell | First | -- |
| Sunday, May 29 |
| » Lost to Twins (18-19), 5-1 | Cleveland Stadium (15-6) | 27-11 | |
| » Starters: Jim Kaat vs Tom Kelley | First | -- |
| » Lost to Twins (19-19), 1-0 | Cleveland Stadium (15-7) | 27-12 | Lost 2 |
| » Starters: Mudcat Grant vs Luis Tiant | First | -- |
| Monday, May 30 |
| » Lost to Angels (22-19), 4-3 | Anaheim Stadium (0-1) | 27-13 | Lost 3 |
| » Starters: Lee Stange vs Jim McGlothlin | First | -- |
| » Lost to Angels (23-19), 5-1 | Anaheim Stadium (0-2) | 27-14 | Lost 4 |
| » Starters: Jack Kralick vs Minnie Rojas | First | -- |
| » Major-league debuts: Minnie Rojas (Angels) |
| Tuesday, May 31 |
| » Defeated Angels (23-20), 7-5 | Anaheim Stadium (1-2) | 28-14 | |
| » Starters: Sonny Siebert vs Marcelino Lopez | First | -- |
| Wednesday, June 1 |
| » Lost to Athletics (16-25), 8-3 | Municipal Stadium (0-1) | 28-15 | |
| » Starters: John O'Donoghue vs Rollie Sheldon | First | -- |
| Thursday, June 2 |
| » Lost to Athletics (17-25), 11-4 | Municipal Stadium (0-2) | 28-16 | Lost 2 |
| » Starters: Gary Bell vs Ralph Terry | First | -- |
| Friday, June 3 |
| » Defeated Twins (20-24), 6-5 | Metropolitan Stadium (1-0) | 29-16 | |
| » Starters: Luis Tiant vs Mudcat Grant | First | -- |
| Saturday, June 4 |
| » Defeated Twins (20-25), 7-4 | Metropolitan Stadium (2-0) | 30-16 | Won 2 |
| » Starters: Tom Kelley vs Camilo Pascual | First | -- |
| » Major-league debuts: Buddy Booker (Indians) |
| Sunday, June 5 |
| » Lost to Twins (21-25), 9-4 | Metropolitan Stadium (2-1) | 30-17 | |
| » Starters: Sonny Siebert vs Dave Boswell | First | -- |
| Tuesday, June 7 |
| » Lost to Yankees (22-25), 7-2 | Cleveland Stadium (15-8) | 30-18 | Lost 2 |
| » Starters: Fritz Peterson vs John O'Donoghue | First | -- |
| Future Indian Heathcliff Slocumb is born in Jamaica, NY. |
| Wednesday, June 8 |
| » Defeated Yankees (22-26), 2-1 | Cleveland Stadium (16-8) | 31-18 | |
| » Starters: Mel Stottlemyre vs Gary Bell | Second | 1½ out |
| Friday, June 10 |
| » Defeated Senators (23-33), 2-0 | Cleveland Stadium (17-8) | 32-18 | Won 2 |
| » Starters: Phil Ortega vs Sonny Siebert | Second | 2 out |
| Saturday, June 11 |
| » Defeated Senators (23-34), 6-4 | Cleveland Stadium (18-8) | 33-18 | Won 3 |
| » Starters: Mike McCormick vs Sam McDowell | First | -- |
| Sunday, June 12 |
| » Defeated Senators (23-35), 6-3 | Cleveland Stadium (19-8) | 34-18 | Won 4 |
| » Starters: Pete Richert vs Gary Bell | First | -- |
| Tuesday, June 14 |
| » Defeated Red Sox (20-36), 8-7 | Cleveland Stadium (20-8) | 35-18 | Won 5 |
| » Starters: Jose Santiago vs Sonny Siebert | Second | 2 out |
| » Lost to Red Sox (21-36), 11-7 | Cleveland Stadium (20-9) | 35-19 | |
| » Starters: Dick Stigman vs Luis Tiant | Second | 2 out |
| Wednesday, June 15 |
| » Defeated Yankees (24-31), 8-5 | Yankee Stadium (4-0) | 36-19 | |
| » Starters: John O'Donoghue vs Fritz Peterson | Second | 2 out |
| Thursday, June 16 |
| » Lost to Yankees (25-31), 7-6 | Yankee Stadium (4-1) | 36-20 | |
| » Starters: Sam McDowell vs Fred Talbot | Second | 2 out |
| Friday, June 17 |
| » Lost to Senators (26-37), 5-4 | Robert F. Kennedy Stadium (1-1) | 36-21 | Lost 2 |
| » Starters: Gary Bell vs Diego Segui | Second | 2 out |
| Saturday, June 18 |
| » Defeated Senators (26-38), 7-2 | Robert F. Kennedy Stadium (2-1) | 37-21 | |
| » Starters: Sonny Siebert vs Phil Ortega | Second | 2 out |
| Future Indian Sandy Alomar Jr. is born in Salinas, P.R. |
| Sunday, June 19 |
| » Lost to Senators (27-38), 2-1 | Robert F. Kennedy Stadium (2-2) | 37-22 | |
| » Starters: Jack Kralick vs Mike McCormick | Second | 2½ out |
| Monday, June 20 |
| » Lost to Senators (28-38), 4-2 | Robert F. Kennedy Stadium (2-3) | 37-23 | Lost 2 |
| » Starters: John O'Donoghue vs Pete Richert | Third | 3 out |
| Tuesday, June 21 |
| » Defeated Red Sox (22-42), 2-1 | Fenway Park (2-0) | 38-23 | |
| » Starters: Gary Bell vs Rollie Sheldon | Third | 2½ out |
| Wednesday, June 22 |
| » Defeated Red Sox (22-43), 3-2 | Fenway Park (3-0) | 39-23 | Won 2 |
| » Starters: Steve Hargan vs Jim Lonborg | Third | 3 out |
| » Lost to Red Sox (23-43), 6-5 | Fenway Park (3-1) | 39-24 | |
| » Starters: Sonny Siebert vs Bob Sadowski | Third | 3 out |
| Thursday, June 23 |
| » Defeated Red Sox (23-44), 8-6 | Fenway Park (4-1) | 40-24 | |
| » Starters: Luis Tiant vs Lee Stange | Third | 3 out |
| Friday, June 24 |
| » Lost to Athletics (28-39), 7-5 | Cleveland Stadium (20-10) | 40-25 | |
| » Starters: Lew Krausse vs Jack Kralick | Third | 3 out |
| Saturday, June 25 |
| » Lost to Athletics (29-39), 7-1 | Cleveland Stadium (20-11) | 40-26 | Lost 2 |
| » Starters: Paul Lindblad vs Gary Bell | Third | 4 out |
| Sunday, June 26 |
| » Lost to Athletics (30-39), 4-2 | Cleveland Stadium (20-12) | 40-27 | Lost 3 |
| » Starters: Catfish Hunter vs Steve Hargan | Third | 4½ out |
| » Defeated Athletics (30-40), 14-3 | Cleveland Stadium (21-12) | 41-27 | |
| » Starters: Bill Stafford vs Sonny Siebert | Third | 4½ out |
| Monday, June 27 |
| » Lost to Twins (34-36), 6-2 | Metropolitan Stadium (2-2) | 41-28 | |
| » Starters: Luis Tiant vs Jim Kaat | Third | 5½ out |
| Tuesday, June 28 |
| » Lost to Twins (35-36), 4-0 | Metropolitan Stadium (2-3) | 41-29 | Lost 2 |
| » Starters: John O'Donoghue vs Camilo Pascual | Third | 5½ out |
| Wednesday, June 29 |
| » Defeated Twins (35-37), 4-1 | Metropolitan Stadium (3-3) | 42-29 | |
| » Starters: Gary Bell vs Mudcat Grant | Third | 5½ out |
| Thursday, June 30 |
| » Defeated Twins (35-38), 4-0 | Metropolitan Stadium (4-3) | 43-29 | Won 2 |
| » Starters: Steve Hargan vs Jim Perry | Third | 5½ out |
| Friday, July 1 |
| » Defeated Angels (39-36), 5-0 | Cleveland Stadium (22-12) | 44-29 | Won 3 |
| » Starters: Dean Chance vs Sam McDowell | Third | 6 out |
| Saturday, July 2 |
| » Defeated Angels (39-37), 5-2 | Cleveland Stadium (23-12) | 45-29 | Won 4 |
| » Starters: Marcelino Lopez vs Sonny Siebert | Third | 6½ out |
| Sunday, July 3 |
| » Lost to Angels (40-37), 10-2 | Cleveland Stadium (23-13) | 45-30 | |
| » Starters: George Brunet vs Gary Bell | Third | 8 out |
| » Lost to Angels (41-37), 4-3 | Cleveland Stadium (23-14) | 45-31 | Lost 2 |
| » Starters: Clyde Wright vs Luis Tiant | Third | 8 out |
| Monday, July 4 |
| » Lost to Twins (36-43), 5-4 | Cleveland Stadium (23-15) | 45-32 | Lost 3 |
| » Starters: Jim Kaat vs Gary Bell | Third | 8 out |
| Tuesday, July 5 |
| » Lost to Twins (37-43), 4-3 | Cleveland Stadium (23-16) | 45-33 | Lost 4 |
| » Starters: Jim Merritt vs Tom Kelley | Third | 8½ out |
| Wednesday, July 6 |
| » Lost to Twins (38-43), 4-3 | Cleveland Stadium (23-17) | 45-34 | Lost 5 |
| » Starters: Dave Boswell vs Sam McDowell | Third | 9 out |
| Future Indian Jeremy Hernandez is born in Burbank, CA. Former Indian Sad Sam Jones dies in Barnesville, OH at the age of 74 |
| Thursday, July 7 |
| Future Indian Dave Burba is born in Dayton, OH. Future Indian Jeff Shaw is born in Washington Court House, OH. |
| Friday, July 8 |
| » Lost to Athletics (37-45), 2-1 | Municipal Stadium (0-3) | 45-35 | Lost 6 |
| » Starters: Sonny Siebert vs Lew Krausse | Third | 10 out |
| Saturday, July 9 |
| » Defeated Athletics (37-46), 6-3 | Municipal Stadium (1-3) | 46-35 | |
| » Starters: Gary Bell vs Catfish Hunter | Third | 9½ out |
| Sunday, July 10 |
| » Lost to Athletics (38-46), 4-1 | Municipal Stadium (1-4) | 46-36 | |
| » Starters: Sam McDowell vs Jim Nash | Third | 10 out |
| » Lost to Athletics (39-46), 5-3 | Municipal Stadium (1-5) | 46-37 | Lost 2 |
| » Starters: Steve Hargan vs Bill Stafford | Third | 10 out |
| Monday, July 11 |
| Future Indian Efrain Valdez is born in Nizao, D.R. |
| Thursday, July 14 |
| » Lost to White Sox (39-47), 2-1 | Comiskey Park I (3-2) | 46-38 | Lost 3 |
| » Starters: Gary Bell vs Tommy John | Third | 10 out |
| Friday, July 15 |
| » Lost to White Sox (40-47), 4-2 | Comiskey Park I (3-3) | 46-39 | Lost 4 |
| » Starters: Sonny Siebert vs Bruce Howard | Fourth | 10 out |
| Saturday, July 16 |
| » Lost to White Sox (41-47), 7-2 | Comiskey Park I (3-4) | 46-40 | Lost 5 |
| » Starters: Steve Hargan vs Joe Horlen | Fourth | 11 out |
| Sunday, July 17 |
| » Defeated Tigers (50-37), 7-3 | Tiger Stadium (4-1) | 47-40 | |
| » Starters: Tom Kelley vs Hank Aguirre | Third | 10 out |
| » Defeated Tigers (50-38), 15-2 | Tiger Stadium (5-1) | 48-40 | Won 2 |
| » Starters: John O'Donoghue vs Joe Sparma | Third | 10 out |
| Monday, July 18 |
| » Defeated Angels (49-42), 6-1 | Cleveland Stadium (24-17) | 49-40 | Won 3 |
| » Starters: Marcelino Lopez vs Gary Bell | Third | 10 out |
| Tuesday, July 19 |
| » Lost to White Sox (43-49), 5-4 | Cleveland Stadium (24-18) | 49-41 | |
| » Starters: Bruce Howard vs Sonny Siebert | Third | 11 out |
| Future Indian David Segui is born in Kansas City, KS. |
| Wednesday, July 20 |
| » Lost to White Sox (44-49), 6-3 | Cleveland Stadium (24-19) | 49-42 | Lost 2 |
| » Starters: Joe Horlen vs Steve Hargan | Fourth | 12 out |
| Thursday, July 21 |
| » Lost to White Sox (45-49), 7-2 | Cleveland Stadium (24-20) | 49-43 | Lost 3 |
| » Starters: John Buzhardt vs Sonny Siebert | Third | 13 out |
| Friday, July 22 |
| » Lost to Tigers (51-41), 10-5 | Cleveland Stadium (24-21) | 49-44 | Lost 4 |
| » Starters: Mickey Lolich vs Gary Bell | Fourth | 14 out |
| Former Indian Frank Delahanty dies in Cleveland, OH at the age of 84. |
| Saturday, July 23 |
| » Defeated Tigers (51-42), 6-5 | Cleveland Stadium (25-21) | 50-44 | |
| » Starters: Joe Sparma vs John O'Donoghue | Fourth | 14 out |
| Sunday, July 24 |
| » Defeated Tigers (51-43), 3-0 | Cleveland Stadium (26-21) | 51-44 | Won 2 |
| » Starters: Denny McLain vs Steve Hargan | Fourth | 13½ out |
| » Lost to Tigers (52-43), 2-1 | Cleveland Stadium (26-22) | 51-45 | |
| » Starters: Johnny Podres vs Tom Kelley | Fourth | 13½ out |
| Monday, July 25 |
| » Defeated Senators (43-59), 6-3 | Robert F. Kennedy Stadium (3-3) | 52-45 | |
| » Starters: Sonny Siebert vs Mike McCormick | Third | 13 out |
| Tuesday, July 26 |
| » Defeated Orioles (66-34), 7-4 | Memorial Stadium (2-3) | 53-45 | Won 2 |
| » Starters: Gary Bell vs Steve Barber | Third | 12 out |
| Wednesday, July 27 |
| » Lost to Orioles (67-34), 7-1 | Memorial Stadium (2-4) | 53-46 | |
| » Starters: John O'Donoghue vs Dave McNally | Third | 13 out |
| » Major-league debuts: Larry Haney (Orioles) |
| Friday, July 29 |
| » Lost to Angels (53-48), 2-1 | Anaheim Stadium (1-3) | 53-47 | Lost 2 |
| » Starters: Sonny Siebert vs George Brunet | Third | 14 out |
| Saturday, July 30 |
| » Lost to Angels (54-48), 2-1 | Anaheim Stadium (1-4) | 53-48 | Lost 3 |
| » Starters: Gary Bell vs Dean Chance | Fourth | 14 out |
| » Major-league debuts: Jay Johnstone (Angels) |
| Sunday, July 31 |
| » Defeated Angels (54-49), 3-2 | Anaheim Stadium (2-4) | 54-48 | |
| » Starters: Steve Hargan vs Fred Newman | Third | 14 out |
| Tuesday, August 2 |
| » Lost to Orioles (70-35), 8-6 | Cleveland Stadium (26-23) | 54-49 | |
| » Starters: Dave McNally vs Sam McDowell | Fourth | 15 out |
| Wednesday, August 3 |
| » Defeated Orioles (70-36), 9-6 | Cleveland Stadium (27-23) | 55-49 | |
| » Starters: Jim Palmer vs Sonny Siebert | Third | 14 out |
| Thursday, August 4 |
| » Defeated Orioles (70-37), 3-1 | Cleveland Stadium (28-23) | 56-49 | Won 2 |
| » Starters: Bill Short vs Gary Bell | Fourth | 13 out |
| Friday, August 5 |
| » Defeated Yankees (48-59), 5-4 | Cleveland Stadium (29-23) | 57-49 | Won 3 |
| » Starters: Fred Talbot vs Steve Hargan | Third | 12½ out |
| » Lost to Yankees (49-59), 3-0 | Cleveland Stadium (29-24) | 57-50 | |
| » Starters: Steve Hamilton vs John O'Donoghue | Third | 12½ out |
| Saturday, August 6 |
| » Lost to Yankees (50-59), 5-4 | Cleveland Stadium (29-25) | 57-51 | Lost 2 |
| » Starters: Jim Bouton vs Sam McDowell | Third | 13½ out |
| Sunday, August 7 |
| » Defeated Yankees (50-60), 6-4 | Cleveland Stadium (30-25) | 58-51 | |
| » Starters: Mel Stottlemyre vs Sonny Siebert | Third | 12 out |
| » Defeated Yankees (50-61), 5-3 | Cleveland Stadium (31-25) | 59-51 | Won 2 |
| » Starters: Al Downing vs Tom Kelley | Third | 12 out |
| Monday, August 8 |
| » Lost to Red Sox (48-67), 3-1 | Fenway Park (4-2) | 59-52 | |
| » Starters: Gary Bell vs Jose Santiago | Third | 12½ out |
| Tuesday, August 9 |
| » Defeated Red Sox (48-68), 5-0 | Fenway Park (5-2) | 60-52 | |
| » Starters: Steve Hargan vs Dennis Bennett | Third | 11½ out |
| Wednesday, August 10 |
| » Lost to Red Sox (49-68), 2-0 | Fenway Park (5-3) | 60-53 | |
| » Starters: Sam McDowell vs Lee Stange | Third | 12½ out |
| Thursday, August 11 |
| » Lost to Red Sox (50-68), 13-3 | Fenway Park (5-4) | 60-54 | Lost 2 |
| » Starters: Sonny Siebert vs Jim Lonborg | Third | 13½ out |
| Friday, August 12 |
| » Defeated Yankees (51-64), 3-2 | Yankee Stadium (5-1) | 61-54 | |
| » Starters: Gary Bell vs Al Downing | Third | 13 out |
| Saturday, August 13 |
| » Defeated Yankees (51-65), 2-1 | Yankee Stadium (6-1) | 62-54 | Won 2 |
| » Starters: Steve Hargan vs Jim Bouton | Third | 13 out |
| Sunday, August 14 |
| » Lost to Yankees (52-65), 7-3 | Yankee Stadium (6-2) | 62-55 | |
| » Starters: Sam McDowell vs Fritz Peterson | Third | 14½ out |
| » Lost to Yankees (53-65), 6-4 | Yankee Stadium (6-3) | 62-56 | Lost 2 |
| » Starters: Jack Kralick vs Fred Talbot | Third | 14½ out |
| Monday, August 15 |
| » Defeated Senators (53-70), 4-3 | Cleveland Stadium (32-25) | 63-56 | |
| » Starters: Mike McCormick vs Sonny Siebert | Third | 14½ out |
| Tuesday, August 16 |
| » Lost to Senators (54-70), 6-5 | Cleveland Stadium (32-26) | 63-57 | |
| » Starters: Jim Hannan vs Gary Bell | Third | 15½ out |
| Wednesday, August 17 |
| » Defeated Senators (54-71), 5-3 | Cleveland Stadium (33-26) | 64-57 | |
| » Starters: Pete Richert vs Steve Hargan | Third | 15½ out |
| Thursday, August 18 |
| » Defeated White Sox (63-59), 2-0 | Cleveland Stadium (34-26) | 65-57 | Won 2 |
| » Starters: Gary Peters vs Sam McDowell | Third | 15 out |
| Friday, August 19 |
| » Defeated White Sox (63-60), 3-2 | Cleveland Stadium (35-26) | 66-57 | Won 3 |
| » Starters: Joe Horlen vs Sonny Siebert | Third | 14 out |
| Saturday, August 20 |
| » Lost to White Sox (64-60), 4-1 | Cleveland Stadium (35-27) | 66-58 | |
| » Manager: George Strickland |
| » Starters: Tommy John vs Gary Bell | Third | 15 out |
| Sunday, August 21 |
| » Lost to White Sox (65-60), 3-2 | Cleveland Stadium (35-28) | 66-59 | Lost 2 |
| » Starters: John Buzhardt vs Steve Hargan | Third | 15 out |
| Tuesday, August 23 |
| » Defeated Orioles (80-44), 2-1 | Memorial Stadium (3-4) | 67-59 | |
| » Starters: Sam McDowell vs Jim Palmer | Third | 14 out |
| Wednesday, August 24 |
| » Defeated Orioles (80-45), 10-4 | Memorial Stadium (4-4) | 68-59 | Won 2 |
| » Starters: Sonny Siebert vs Eddie Watt | Third | 13 out |
| Thursday, August 25 |
| » Lost to Orioles (81-45), 4-3 | Memorial Stadium (4-5) | 68-60 | |
| » Starters: Gary Bell vs Dave McNally | Third | 14 out |
| Future Indian Albert Belle is born in Shreveport, LA. Former Indian Sam Zoldak dies in New Hyde Park, NY at the age of 48 |
| Friday, August 26 |
| » Lost to Senators (59-73), 1-0 | Robert F. Kennedy Stadium (3-4) | 68-61 | Lost 2 |
| » Starters: Steve Hargan vs Mike McCormick | Third | 15 out |
| Saturday, August 27 |
| » Lost to Senators (60-73), 3-1 | Robert F. Kennedy Stadium (3-5) | 68-62 | Lost 3 |
| » Starters: Sam McDowell vs Phil Ortega | Fourth | 15 out |
| Sunday, August 28 |
| » Lost to Senators (61-73), 3-2 | Robert F. Kennedy Stadium (3-6) | 68-63 | Lost 4 |
| » Starters: Sonny Siebert vs Pete Richert | Fourth | 15 out |
| Monday, August 29 |
| » Lost to White Sox (69-64), 2-0 | Comiskey Park I (3-5) | 68-64 | Lost 5 |
| » Starters: Gary Bell vs Tommy John | Fifth | 15 out |
| Tuesday, August 30 |
| » Defeated White Sox (69-65), 6-2 | Comiskey Park I (4-5) | 69-64 | |
| » Starters: Steve Hargan vs John Buzhardt | Fourth | 14 out |
| Wednesday, August 31 |
| » Lost to Orioles (83-49), 5-1 | Cleveland Stadium (35-29) | 69-65 | |
| » Starters: John Miller vs Sam McDowell | Fifth | 15 out |
| Thursday, September 1 |
| » Defeated Orioles (83-50), 4-1 | Cleveland Stadium (36-29) | 70-65 | |
| » Starters: Jim Palmer vs Sonny Siebert | Fourth | 14 out |
| Friday, September 2 |
| » Lost to Tigers (73-61), 4-2 | Cleveland Stadium (36-30) | 70-66 | |
| » Starters: Denny McLain vs Gary Bell | Fifth | 14½ out |
| » Lost to Tigers (74-61), 7-5 | Cleveland Stadium (36-31) | 70-67 | Lost 2 |
| » Starters: Joe Sparma vs John O'Donoghue | Fifth | 14½ out |
| Saturday, September 3 |
| » Lost to Tigers (75-61), 8-1 | Cleveland Stadium (36-32) | 70-68 | Lost 3 |
| » Starters: Earl Wilson vs Tom Kelley | Fifth | 15½ out |
| Sunday, September 4 |
| » Lost to Tigers (76-61), 4-3 | Cleveland Stadium (36-33) | 70-69 | Lost 4 |
| » Starters: Hank Aguirre vs Sam McDowell | Fifth | 16½ out |
| Monday, September 5 |
| » Lost to Red Sox (63-80), 5-1 | Cleveland Stadium (36-34) | 70-70 | Lost 5 |
| » Starters: Lee Stange vs Steve Hargan | Fifth | 17½ out |
| » Defeated Red Sox (63-81), 3-1 | Cleveland Stadium (37-34) | 71-70 | |
| » Starters: Dennis Bennett vs Sonny Siebert | Fifth | 17½ out |
| Tuesday, September 6 |
| » Defeated Red Sox (63-82), 6-2 | Cleveland Stadium (38-34) | 72-70 | Won 2 |
| » Starters: Hank Fischer vs Gary Bell | Fifth | 17½ out |
| Wednesday, September 7 |
| » Lost to Red Sox (64-82), 5-4 | Cleveland Stadium (38-35) | 72-71 | |
| » Starters: Jim Lonborg vs George Culver | Fifth | 18½ out |
| » Major-league debuts: George Culver (Indians) |
| Friday, September 9 |
| » Defeated Angels (70-71), 8-7 | Cleveland Stadium (39-35) | 73-71 | |
| » Starters: Dean Chance vs Sam McDowell | Fifth | 17½ out |
| Saturday, September 10 |
| » Lost to Angels (71-71), 9-2 | Cleveland Stadium (39-36) | 73-72 | |
| » Starters: Marcelino Lopez vs Bob Heffner | Fifth | 17½ out |
| Sunday, September 11 |
| » Lost to Angels (72-71), 8-2 | Cleveland Stadium (39-37) | 73-73 | Lost 2 |
| » Starters: Fred Newman vs Gary Bell | Sixth | 17½ out |
| Tuesday, September 13 |
| » Lost to Athletics (67-80), 3-1 | Cleveland Stadium (39-38) | 73-74 | Lost 3 |
| » Starters: Paul Lindblad vs Steve Hargan | Sixth | 17½ out |
| Wednesday, September 14 |
| » Lost to Athletics (68-80), 3-0 | Cleveland Stadium (39-39) | 73-75 | Lost 4 |
| » Starters: Blue Moon Odom vs Sam McDowell | Sixth | 18 out |
| Thursday, September 15 |
| » Lost to Athletics (69-80), 1-0 | Cleveland Stadium (39-40) | 73-76 | Lost 5 |
| » Starters: Bill Edgerton vs Sonny Siebert | Sixth | 19½ out |
| Friday, September 16 |
| » Lost to Tigers (83-65), 3-1 | Tiger Stadium (5-2) | 73-77 | Lost 6 |
| » Starters: Gary Bell vs Hank Aguirre | Sixth | 19½ out |
| Saturday, September 17 |
| » Defeated Tigers (83-66), 6-2 | Tiger Stadium (6-2) | 74-77 | |
| » Starters: Steve Hargan vs Mickey Lolich | Sixth | 18½ out |
| Sunday, September 18 |
| » Defeated Tigers (83-67), 6-5 | Tiger Stadium (7-2) | 75-77 | Won 2 |
| » Starters: Sam McDowell vs Denny McLain | Sixth | 17½ out |
| Tuesday, September 20 |
| » Defeated Twins (83-69), 4-1 | Cleveland Stadium (40-40) | 76-77 | Won 3 |
| » Starters: Jim Perry vs Luis Tiant | Fifth | 18 out |
| Wednesday, September 21 |
| » Defeated Twins (83-70), 6-2 | Cleveland Stadium (41-40) | 77-77 | Won 4 |
| » Starters: Jim Kaat vs Steve Hargan | Fifth | 18 out |
| Friday, September 23 |
| » Lost to Athletics (71 |
