| Saturday, February 5 |
| Future Cardinal Ray Giannelli is born in Brooklyn, NY. |
| Tuesday, February 8 |
| Former Cardinal Gene Paulette dies in Little Rock, AR at the age of 75. |
| Thursday, February 24 |
| Future Cardinal Rene Arocha is born in Havana, Cuba. Future Cardinal Rod Brewer is born in Eustis, FL. |
| Thursday, March 10 |
| Future Cardinal Mike Timlin is born in Midland, TX. |
| Monday, March 14 |
| Former Cardinal Lee Magee dies in Columbus, OH at the age of 77. |
| Monday, April 11 |
| Future Cardinal Steve Scarsone is born in Anaheim, CA. |
| Wednesday, April 13 |
| » Lost to Phillies (1-0), 3-2 | Sportsman's Park III (0-1) | 0-1 | |
| » Starters: Chris Short vs Curt Simmons | Fifth | 1½ out |
| Thursday, April 14 |
| » Lost to Phillies (2-0), 5-4 | Sportsman's Park III (0-2) | 0-2 | Lost 2 |
| » Starters: Ray Herbert vs Larry Jaster | Fifth | 2 out |
| Friday, April 15 |
| » Defeated Pirates (2-1), 9-2 | Forbes Field (1-0) | 1-2 | |
| » Starters: Bob Gibson vs Don Cardwell | Fifth | 2 out |
| » Major-league debuts: Woodie Fryman (Pirates) |
| Saturday, April 16 |
| » Lost to Pirates (3-1), 5-3 | Forbes Field (1-1) | 1-3 | |
| » Starters: Ray Washburn vs Tommie Sisk | Sixth | 2½ out |
| Sunday, April 17 |
| » Lost to Pirates (4-1), 6-5 | Forbes Field (1-2) | 1-4 | Lost 2 |
| » Starters: Nelson Briles vs Bob Veale | Seventh | 3½ out |
| Tuesday, April 19 |
| » Defeated Mets (2-2), 5-2 | Shea Stadium (1-0) | 2-4 | |
| » Starters: Larry Jaster vs Jack Fisher | Sixth | 3½ out |
| Thursday, April 21 |
| » Defeated Mets (2-3), 5-4 | Shea Stadium (2-0) | 3-4 | Won 2 |
| » Starters: Bob Gibson vs Rob Gardner | Fifth | 4 out |
| Friday, April 22 |
| » Defeated Pirates (8-2), 7-5 | Sportsman's Park III (1-2) | 4-4 | Won 3 |
| » Starters: Tommie Sisk vs Ray Washburn | Fifth | 3 out |
| Saturday, April 23 |
| » Lost to Pirates (9-2), 5-4 | Sportsman's Park III (1-3) | 4-5 | |
| » Starters: Steve Blass vs Nelson Briles | Sixth | 4 out |
| Sunday, April 24 |
| » Defeated Pirates (9-3), 5-2 | Sportsman's Park III (2-3) | 5-5 | |
| » Starters: Don Cardwell vs Ray Sadecki | Third | 3 out |
| Monday, April 25 |
| » Defeated Dodgers (7-6), 2-0 | Dodger Stadium (1-0) | 6-5 | Won 2 |
| » Starters: Larry Jaster vs Claude Osteen | Third | 2 out |
| Future Cardinal Darren Holmes is born in Asheville, NC. Future Cardinal Erik Pappas is born in Chicago, IL. |
| Tuesday, April 26 |
| » Lost to Dodgers (8-6), 4-2 | Dodger Stadium (1-1) | 6-6 | |
| » Starters: Bob Gibson vs Sandy Koufax | Fifth | 2½ out |
| » Major-league debuts: Jimy Williams (Cardinals) |
| Wednesday, April 27 |
| » Lost to Astros (7-8), 3-1 | Astrodome (0-1) | 6-7 | Lost 2 |
| » Starters: Ray Washburn vs Dave Giusti | Fifth | 3 out |
| Thursday, April 28 |
| » Lost to Astros (8-8), 4-2 | Astrodome (0-2) | 6-8 | Lost 3 |
| » Starters: Nelson Briles vs Robin Roberts | Sixth | 4 out |
| Friday, April 29 |
| » Defeated Giants (10-7), 5-1 | Candlestick Park (1-0) | 7-8 | |
| » Starters: Ray Sadecki vs Bob Shaw | Sixth | 3 out |
| Saturday, April 30 |
| » Lost to Giants (11-7), 6-1 | Candlestick Park (1-1) | 7-9 | |
| » Starters: Larry Jaster vs Bobby Bolin | Seventh | 3½ out |
| Sunday, May 1 |
| » Lost to Giants (12-7), 2-0 | Candlestick Park (1-2) | 7-10 | Lost 2 |
| » Starters: Bob Gibson vs Gaylord Perry | Sixth | 4½ out |
| Tuesday, May 3 |
| » Defeated Mets (5-8), 5-2 | Sportsman's Park III (3-3) | 8-10 | |
| » Starters: Tug McGraw vs Ray Washburn | Sixth | 4½ out |
| Wednesday, May 4 |
| » Lost to Mets (6-8), 8-0 | Sportsman's Park III (3-4) | 8-11 | |
| » Starters: Jack Hamilton vs Ray Sadecki | Seventh | 5½ out |
| Friday, May 6 |
| » Lost to Giants (16-7), 4-2 | Sportsman's Park III (3-5) | 8-12 | Lost 2 |
| » Starters: Gaylord Perry vs Bob Gibson | Seventh | 6½ out |
| Saturday, May 7 |
| » Lost to Giants (17-7), 15-2 | Sportsman's Park III (3-6) | 8-13 | Lost 3 |
| » Starters: Juan Marichal vs Art Mahaffey | Seventh | 7½ out |
| Sunday, May 8 |
| » Lost to Giants (18-7), 10-5 | Sportsman's Park III (3-7) | 8-14 | Lost 4 |
| » Starters: Bob Shaw vs Larry Jaster | Seventh | 8½ out |
| Tuesday, May 10 |
| » Defeated Cubs (6-18), 8-0 | Wrigley Field (1-0) | 9-14 | |
| » Starters: Bob Gibson vs Bill Faul | Ninth | 8½ out |
| Thursday, May 12 |
| » Defeated Braves (14-16), 4-3 | Busch Stadium II (1-0) | 10-14 | Won 2 |
| » Starters: Wade Blasingame vs Ray Washburn | Eighth | 9 out |
| Friday, May 13 |
| » Defeated Braves (14-17), 8-0 | Busch Stadium II (2-0) | 11-14 | Won 3 |
| » Starters: Ken Johnson vs Al Jackson | Seventh | 9 out |
| Saturday, May 14 |
| » Lost to Braves (15-17), 3-0 | Busch Stadium II (2-1) | 11-15 | |
| » Starters: Denny Lemaster vs Bob Gibson | Eighth | 9 out |
| Sunday, May 15 |
| » Defeated Braves (15-18), 5-3 | Busch Stadium II (3-1) | 12-15 | |
| » Starters: Tony Cloninger vs Art Mahaffey | Eighth | 8 out |
| Tuesday, May 17 |
| » Lost to Phillies (14-13), 5-3 | Shibe Park (0-1) | 12-16 | |
| » Starters: Curt Simmons vs Chris Short | Ninth | 8 out |
| Wednesday, May 18 |
| » Lost to Phillies (15-13), 4-3 | Shibe Park (0-2) | 12-17 | Lost 2 |
| » Starters: Bob Gibson vs Jim Bunning | Ninth | 9 out |
| Thursday, May 19 |
| » Defeated Phillies (15-14), 2-0 | Shibe Park (1-2) | 13-17 | |
| » Starters: Al Jackson vs Larry Jackson | Ninth | 8 out |
| Friday, May 20 |
| » Lost to Reds (15-15), 5-3 | Crosley Field (0-1) | 13-18 | |
| » Starters: Ray Washburn vs Joey Jay | Ninth | 8 out |
| Saturday, May 21 |
| » Lost to Reds (16-15), 4-1 | Crosley Field (0-2) | 13-19 | Lost 2 |
| » Starters: Art Mahaffey vs Jim Maloney | Eighth | 9 out |
| Sunday, May 22 |
| » Defeated Reds (16-16), 4-3 | Crosley Field (1-2) | 14-19 | |
| » Starters: Bob Gibson vs Jim O'Toole | Ninth | 8½ out |
| Former Cardinal Arnold Hauser dies in Aurora, IL at the age of 78. |
| Tuesday, May 24 |
| » Lost to Cubs (10-24), 2-0 | Busch Stadium II (3-2) | 14-20 | |
| » Starters: Bill Hands vs Al Jackson | Ninth | 9½ out |
| Wednesday, May 25 |
| » Defeated Cubs (10-25), 9-1 | Busch Stadium II (4-2) | 15-20 | |
| » Starters: Ken Holtzman vs Nelson Briles | Seventh | 8½ out |
| Thursday, May 26 |
| » Defeated Cubs (10-26), 3-2 | Busch Stadium II (5-2) | 16-20 | Won 2 |
| » Starters: Dick Ellsworth vs Bob Gibson | Seventh | 8½ out |
| Friday, May 27 |
| » Lost to Reds (19-17), 6-5 | Busch Stadium II (5-3) | 16-21 | |
| » Starters: Jim Maloney vs Art Mahaffey | Eighth | 8½ out |
| Saturday, May 28 |
| » Defeated Reds (19-18), 3-1 | Busch Stadium II (6-3) | 17-21 | |
| » Starters: Jim O'Toole vs Al Jackson | Eighth | 7½ out |
| Sunday, May 29 |
| » Defeated Reds (19-19), 3-2 | Busch Stadium II (7-3) | 18-21 | Won 2 |
| » Starters: Joey Jay vs Nelson Briles | Seventh | 7½ out |
| Monday, May 30 |
| » Defeated Astros (25-20), 3-1 | Busch Stadium II (8-3) | 19-21 | Won 3 |
| » Starters: Turk Farrell vs Bob Gibson | Seventh | 7½ out |
| Tuesday, May 31 |
| » Defeated Astros (25-21), 3-0 | Busch Stadium II (9-3) | 20-21 | Won 4 |
| » Starters: Barry Latman vs Ray Washburn | Sixth | 7½ out |
| Wednesday, June 1 |
| » Lost to Dodgers (28-18), 1-0 | Busch Stadium II (9-4) | 20-22 | |
| » Starters: Sandy Koufax vs Al Jackson | Sixth | 8½ out |
| Thursday, June 2 |
| » Lost to Dodgers (29-18), 2-0 | Busch Stadium II (9-5) | 20-23 | Lost 2 |
| » Starters: Don Sutton vs Nelson Briles | Sixth | 9½ out |
| Friday, June 3 |
| » Defeated Braves (20-30), 3-2 | Atlanta-Fulton County Stadium (1-0) | 21-23 | |
| » Starters: Bob Gibson vs Hank Fischer | Sixth | 8½ out |
| Saturday, June 4 |
| » Lost to Braves (21-30), 2-1 | Atlanta-Fulton County Stadium (1-1) | 21-24 | |
| » Starters: Curt Simmons vs Arnold Umbach | Sixth | 9 out |
| » Lost to Braves (22-30), 4-1 | Atlanta-Fulton County Stadium (1-2) | 21-25 | Lost 2 |
| » Starters: Tracy Stallard vs Tony Cloninger | Sixth | 9 out |
| Sunday, June 5 |
| » Lost to Braves (23-30), 14-4 | Atlanta-Fulton County Stadium (1-3) | 21-26 | Lost 3 |
| » Starters: Al Jackson vs Clay Carroll | Seventh | 10 out |
| Tuesday, June 7 |
| » Lost to Pirates (30-20), 9-1 | Forbes Field (1-3) | 21-27 | Lost 4 |
| » Starters: Bob Gibson vs Don Cardwell | Eighth | 9½ out |
| Future Cardinal Heathcliff Slocumb is born in Jamaica, NY. |
| Wednesday, June 8 |
| » Defeated Pirates (30-21), 11-5 | Forbes Field (2-3) | 22-27 | |
| » Starters: Nelson Briles vs Vern Law | Sixth | 8½ out |
| Thursday, June 9 |
| » Defeated Pirates (30-22), 4-2 | Forbes Field (3-3) | 23-27 | Won 2 |
| » Starters: Al Jackson vs Woodie Fryman | Sixth | 8½ out |
| Friday, June 10 |
| » Defeated Phillies (30-23), 5-4 | Shibe Park (2-2) | 24-27 | Won 3 |
| » Starters: Curt Simmons vs Rick Wise | Sixth | 7½ out |
| Saturday, June 11 |
| » Defeated Phillies (30-24), 2-0 | Shibe Park (3-2) | 25-27 | Won 4 |
| » Starters: Bob Gibson vs Jim Bunning | Sixth | 7½ out |
| Sunday, June 12 |
| » Lost to Phillies (31-24), 5-3 | Shibe Park (3-3) | 25-28 | |
| » Starters: Nelson Briles vs Chris Short | Sixth | 7½ out |
| Monday, June 13 |
| » Lost to Mets (21-30), 5-2 | Shea Stadium (2-1) | 25-29 | Lost 2 |
| » Starters: Al Jackson vs Bob Shaw | Sixth | 8 out |
| » Defeated Mets (21-31), 4-1 | Shea Stadium (3-1) | 26-29 | |
| » Starters: Ray Washburn vs Jack Hamilton | Sixth | 8 out |
| Future Cardinal Scott Coolbaugh is born in Binghamton, NY. |
| Tuesday, June 14 |
| » Defeated Mets (21-32), 9-2 | Shea Stadium (4-1) | 27-29 | Won 2 |
| » Starters: Tracy Stallard vs Dick Rusteck | Sixth | 8 out |
| Former Cardinal Bill Walker dies in E.St.Louis, IL at the age of 63. |
| Wednesday, June 15 |
| » Defeated Pirates (33-25), 1-0 | Busch Stadium II (10-5) | 28-29 | Won 3 |
| » Starters: Bob Veale vs Bob Gibson | Fifth | 8 out |
| Thursday, June 16 |
| » Lost to Pirates (34-25), 2-1 | Busch Stadium II (10-6) | 28-30 | |
| » Starters: Steve Blass vs Nelson Briles | Sixth | 9 out |
| Friday, June 17 |
| » Lost to Phillies (35-27), 6-5 | Busch Stadium II (10-7) | 28-31 | Lost 2 |
| » Starters: Larry Jackson vs Curt Simmons | Sixth | 10 out |
| Saturday, June 18 |
| » Defeated Phillies (35-28), 3-2 | Busch Stadium II (11-7) | 29-31 | |
| » Starters: Bob Buhl vs Al Jackson | Sixth | 9 out |
| Sunday, June 19 |
| » Defeated Phillies (35-29), 1-0 | Busch Stadium II (12-7) | 30-31 | Won 2 |
| » Starters: Jim Bunning vs Ray Washburn | Sixth | 7½ out |
| » Defeated Phillies (35-30), 5-1 | Busch Stadium II (13-7) | 31-31 | Won 3 |
| » Starters: Rick Wise vs Bob Gibson | Sixth | 7½ out |
| Monday, June 20 |
| » Defeated Mets (24-37), 4-2 | Busch Stadium II (14-7) | 32-31 | Won 4 |
| » Starters: Dick Selma vs Nelson Briles | Sixth | 7 out |
| Tuesday, June 21 |
| » Lost to Mets (25-37), 2-1 | Busch Stadium II (14-8) | 32-32 | |
| » Starters: Bob Shaw vs Tracy Stallard | Sixth | 8 out |
| Wednesday, June 22 |
| » Lost to Mets (26-37), 2-0 | Busch Stadium II (14-9) | 32-33 | Lost 2 |
| » Starters: Jack Fisher vs Al Jackson | Sixth | 9½ out |
| Thursday, June 23 |
| » Defeated Astros (36-32), 2-1 | Astrodome (1-2) | 33-33 | |
| » Starters: Bob Gibson vs Dave Giusti | Fifth | 9½ out |
| Friday, June 24 |
| » Lost to Astros (37-32), 4-1 | Astrodome (1-3) | 33-34 | |
| » Starters: Nelson Briles vs Larry Dierker | Sixth | 9½ out |
| Saturday, June 25 |
| » Lost to Astros (38-32), 3-2 | Astrodome (1-4) | 33-35 | Lost 2 |
| » Starters: Ray Washburn vs Mike Cuellar | Seventh | 9½ out |
| Sunday, June 26 |
| » Lost to Astros (39-32), 6-3 | Astrodome (1-5) | 33-36 | Lost 3 |
| » Starters: Al Jackson vs Turk Farrell | Seventh | 10½ out |
| Monday, June 27 |
| » Lost to Giants (46-27), 2-1 | Busch Stadium II (14-10) | 33-37 | Lost 4 |
| » Starters: Ron Herbel vs Bob Gibson | Seventh | 11½ out |
| Tuesday, June 28 |
| » Lost to Giants (47-27), 7-1 | Busch Stadium II (14-11) | 33-38 | Lost 5 |
| » Starters: Bobby Bolin vs Tracy Stallard | Seventh | 12½ out |
| Wednesday, June 29 |
| » Defeated Giants (47-28), 2-1 | Busch Stadium II (15-11) | 34-38 | |
| » Starters: Juan Marichal vs Nelson Briles | Seventh | 11½ out |
| Friday, July 1 |
| » Defeated Dodgers (41-33), 2-0 | Dodger Stadium (2-1) | 35-38 | Won 2 |
| » Starters: Al Jackson vs Sandy Koufax | Seventh | 12 out |
| Saturday, July 2 |
| » Lost to Dodgers (42-33), 7-2 | Dodger Stadium (2-2) | 35-39 | |
| » Starters: Bob Gibson vs Claude Osteen | Seventh | 12 out |
| Sunday, July 3 |
| » Defeated Dodgers (42-34), 2-0 | Dodger Stadium (3-2) | 36-39 | |
| » Starters: Larry Jaster vs Don Drysdale | Sixth | 11 out |
| Monday, July 4 |
| » Defeated Giants (49-31), 6-2 | Candlestick Park (2-2) | 37-39 | Won 2 |
| » Starters: Ray Washburn vs Juan Marichal | Sixth | 11 out |
| » Lost to Giants (50-31), 3-2 | Candlestick Park (2-3) | 37-40 | |
| » Starters: Nelson Briles vs Gaylord Perry | Sixth | 11 out |
| Tuesday, July 5 |
| » Defeated Giants (50-32), 3-1 | Candlestick Park (3-3) | 38-40 | |
| » Starters: Al Jackson vs Ron Herbel | Sixth | 10 out |
| Wednesday, July 6 |
| » Lost to Giants (51-32), 3-2 | Candlestick Park (3-4) | 38-41 | |
| » Starters: Tracy Stallard vs Bobby Bolin | Sixth | 11 out |
| Friday, July 8 |
| » Lost to Astros (44-39), 6-1 | Busch Stadium II (15-12) | 38-42 | Lost 2 |
| » Starters: Bob Bruce vs Bob Gibson | Sixth | 12½ out |
| Saturday, July 9 |
| » Defeated Astros (44-40), 7-1 | Busch Stadium II (16-12) | 39-42 | |
| » Starters: Larry Dierker vs Ray Washburn | Sixth | 12½ out |
| Sunday, July 10 |
| » Lost to Astros (45-40), 6-5 | Busch Stadium II (16-13) | 39-43 | |
| » Starters: Dave Giusti vs Al Jackson | Sixth | 12½ out |
| Thursday, July 14 |
| » Lost to Reds (38-46), 9-2 | Crosley Field (1-3) | 39-44 | Lost 2 |
| » Starters: Nelson Briles vs Jim Maloney | Sixth | 12 out |
| » Defeated Reds (38-47), 9-7 | Crosley Field (2-3) | 40-44 | |
| » Starters: Tracy Stallard vs Milt Pappas | Sixth | 12 out |
| Friday, July 15 |
| » Defeated Reds (38-48), 9-2 | Crosley Field (3-3) | 41-44 | Won 2 |
| » Starters: Ray Washburn vs Sammy Ellis | Sixth | 12 out |
| Saturday, July 16 |
| » Lost to Reds (39-48), 5-3 | Crosley Field (3-4) | 41-45 | |
| » Starters: Al Jackson vs Jim O'Toole | Sixth | 12 out |
| Sunday, July 17 |
| » Defeated Cubs (28-59), 4-3 | Busch Stadium II (17-13) | 42-45 | |
| » Starters: Curt Simmons vs Nelson Briles | Seventh | 12 out |
| » Lost to Cubs (29-59), 7-2 | Busch Stadium II (17-14) | 42-46 | |
| » Starters: Ken Holtzman vs Art Mahaffey | Seventh | 12 out |
| Monday, July 18 |
| » Defeated Cubs (29-60), 7-6 | Busch Stadium II (18-14) | 43-46 | |
| » Starters: Dick Ellsworth vs Larry Jaster | Seventh | 11 out |
| Tuesday, July 19 |
| » Defeated Braves (44-48), 10-9 | Busch Stadium II (19-14) | 44-46 | Won 2 |
| » Starters: Tony Cloninger vs Tracy Stallard | Sixth | 10½ out |
| Wednesday, July 20 |
| » Defeated Braves (44-49), 6-3 | Busch Stadium II (20-14) | 45-46 | Won 3 |
| » Starters: Ken Johnson vs Ray Washburn | Sixth | 10½ out |
| Thursday, July 21 |
| » Defeated Braves (44-50), 7-4 | Busch Stadium II (21-14) | 46-46 | Won 4 |
| » Starters: Denny Lemaster vs Al Jackson | Sixth | 9½ out |
| Friday, July 22 |
| » Defeated Cubs (30-64), 9-4 | Wrigley Field (2-0) | 47-46 | Won 5 |
| » Starters: Don Dennis vs Dick Ellsworth | Sixth | 8½ out |
| Saturday, July 23 |
| » Defeated Cubs (30-65), 4-0 | Wrigley Field (3-0) | 48-46 | Won 6 |
| » Starters: Bob Gibson vs Robin Roberts | Fifth | 8½ out |
| Sunday, July 24 |
| » Lost to Cubs (31-65), 10-7 | Wrigley Field (3-1) | 48-47 | |
| » Starters: Nelson Briles vs Cal Koonce | Fifth | 9 out |
| » Defeated Cubs (31-66), 7-4 | Wrigley Field (4-1) | 49-47 | |
| » Starters: Larry Jaster vs Ken Holtzman | Fifth | 9 out |
| Tuesday, July 26 |
| » Defeated Braves (45-53), 4-3 | Atlanta-Fulton County Stadium (2-3) | 50-47 | Won 2 |
| » Starters: Al Jackson vs Denny Lemaster | Fifth | 8½ out |
| Wednesday, July 27 |
| » Defeated Braves (45-54), 9-7 | Atlanta-Fulton County Stadium (3-3) | 51-47 | Won 3 |
| » Starters: Ray Washburn vs Joey Jay | Fifth | 7½ out |
| Thursday, July 28 |
| » Defeated Braves (45-55), 7-5 | Atlanta-Fulton County Stadium (4-3) | 52-47 | Won 4 |
| » Starters: Bob Gibson vs Don Schwall | Fourth | 7 out |
| Friday, July 29 |
| » Defeated Dodgers (58-41), 4-0 | Busch Stadium II (22-14) | 53-47 | Won 5 |
| » Starters: Don Drysdale vs Larry Jaster | Fourth | 7 out |
| Saturday, July 30 |
| » Defeated Dodgers (58-42), 3-1 | Busch Stadium II (23-14) | 54-47 | Won 6 |
| » Starters: Don Sutton vs Al Jackson | Fourth | 6 out |
| Sunday, July 31 |
| » Lost to Dodgers (59-42), 6-4 | Busch Stadium II (23-15) | 54-48 | |
| » Starters: Claude Osteen vs Steve Carlton | Fifth | 5½ out |
| Monday, August 1 |
| » Lost to Reds (51-53), 3-2 | Busch Stadium II (23-16) | 54-49 | Lost 2 |
| » Starters: Jim O'Toole vs Ray Washburn | Fifth | 6½ out |
| Tuesday, August 2 |
| » Lost to Reds (52-53), 6-3 | Busch Stadium II (23-17) | 54-50 | Lost 3 |
| » Starters: Joe Nuxhall vs Al Jackson | Fifth | 7½ out |
| Wednesday, August 3 |
| » Lost to Reds (53-53), 3-1 | Busch Stadium II (23-18) | 54-51 | Lost 4 |
| » Starters: Jim Maloney vs Bob Gibson | Fifth | 8½ out |
| Thursday, August 4 |
| » Lost to Reds (54-53), 7-1 | Busch Stadium II (23-19) | 54-52 | Lost 5 |
| » Starters: Sammy Ellis vs Larry Jaster | Fifth | 8½ out |
| Friday, August 5 |
| » Defeated Mets (48-59), 7-1 | Shea Stadium (5-1) | 55-52 | |
| » Starters: Steve Carlton vs Bob Shaw | Fifth | 7½ out |
| Saturday, August 6 |
| » Defeated Mets (48-60), 10-8 | Shea Stadium (6-1) | 56-52 | Won 2 |
| » Starters: Ray Washburn vs Bob Friend | Fifth | 7½ out |
| Sunday, August 7 |
| » Defeated Mets (48-61), 4-1 | Shea Stadium (7-1) | 57-52 | Won 3 |
| » Starters: Bob Gibson vs Gerry Arrigo | Fifth | 7 out |
| » Lost to Mets (49-61), 4-1 | Shea Stadium (7-2) | 57-53 | |
| » Starters: Al Jackson vs Jack Fisher | Fifth | 7 out |
| Tuesday, August 9 |
| » Defeated Phillies (60-52), 3-2 | Busch Stadium II (24-19) | 58-53 | |
| » Starters: Jim Bunning vs Larry Jaster | Fifth | 7 out |
| Wednesday, August 10 |
| » Lost to Phillies (61-52), 5-1 | Busch Stadium II (24-20) | 58-54 | |
| » Starters: Chris Short vs Steve Carlton | Fifth | 8 out |
| Thursday, August 11 |
| » Defeated Phillies (61-53), 5-1 | Busch Stadium II (25-20) | 59-54 | |
| » Starters: Larry Jackson vs Al Jackson | Fifth | 8 out |
| Friday, August 12 |
| » Lost to Mets (50-64), 6-2 | Busch Stadium II (25-21) | 59-55 | |
| » Starters: Jack Fisher vs Ray Washburn | Fifth | 9 out |
| Saturday, August 13 |
| » Defeated Mets (50-65), 9-6 | Busch Stadium II (26-21) | 60-55 | |
| » Starters: Bob Friend vs Bob Gibson | Fifth | 8 out |
| Sunday, August 14 |
| » Lost to Mets (51-65), 5-4 | Busch Stadium II (26-22) | 60-56 | |
| » Starters: Dennis Ribant vs Larry Jaster | Fifth | 8½ out |
| » Defeated Mets (51-66), 4-3 | Busch Stadium II (27-22) | 61-56 | |
| » Starters: Bob Shaw vs Steve Carlton | Fifth | 8½ out |
| Tuesday, August 16 |
| » Lost to Giants (70-50), 3-1 | Candlestick Park (3-5) | 61-57 | |
| » Starters: Al Jackson vs Gaylord Perry | Fifth | 9½ out |
| Wednesday, August 17 |
| » Lost to Giants (71-50), 4-3 | Candlestick Park (3-6) | 61-58 | Lost 2 |
| » Starters: Ray Washburn vs Juan Marichal | Fifth | 9½ out |
| Thursday, August 18 |
| » Lost to Dodgers (68-51), 3-1 | Dodger Stadium (3-3) | 61-59 | Lost 3 |
| » Starters: Bob Gibson vs Don Drysdale | Fifth | 9½ out |
| Friday, August 19 |
| » Defeated Dodgers (68-52), 4-0 | Dodger Stadium (4-3) | 62-59 | |
| » Starters: Larry Jaster vs Claude Osteen | Fifth | 8½ out |
| Future Cardinal Woody Williams is born in Houston, TX. |
| Saturday, August 20 |
| » Defeated Dodgers (68-53), 3-2 | Dodger Stadium (5-3) | 63-59 | Won 2 |
| » Starters: Al Jackson vs Don Sutton | Fifth | 8½ out |
| Sunday, August 21 |
| » Lost to Dodgers (69-53), 4-1 | Dodger Stadium (5-4) | 63-60 | |
| » Starters: Ray Washburn vs Sandy Koufax | Fifth | 9½ out |
| Monday, August 22 |
| » Defeated Astros (56-69), 3-0 | Astrodome (2-5) | 64-60 | |
| » Starters: Steve Carlton vs Bob Bruce | Fifth | 9½ out |
| Tuesday, August 23 |
| » Defeated Astros (56-70), 3-0 | Astrodome (3-5) | 65-60 | Won 2 |
| » Starters: Bob Gibson vs Larry Dierker | Fifth | 9½ out |
| Wednesday, August 24 |
| » Lost to Astros (57-70), 7-2 | Astrodome (3-6) | 65-61 | |
| » Starters: Larry Jaster vs Mike Cuellar | Fifth | 9½ out |
| Former Cardinal Wheezer Dell dies in Independence, CA at the age of 81. |
| Friday, August 26 |
| » Lost to Pirates (75-52), 7-4 | Busch Stadium II (27-23) | 65-62 | Lost 2 |
| » Starters: Woodie Fryman vs Al Jackson | Fifth | 10 out |
| Saturday, August 27 |
| » Defeated Pirates (75-53), 5-1 | Busch Stadium II (28-23) | 66-62 | |
| » Starters: Steve Blass vs Bob Gibson | Fifth | 9½ out |
| Sunday, August 28 |
| » Defeated Pirates (75-54), 3-2 | Busch Stadium II (29-23) | 67-62 | Won 2 |
| » Starters: Vern Law vs Ray Washburn | Fourth | 9 out |
| » Lost to Pirates (76-54), 5-1 | Busch Stadium II (29-24) | 67-63 | |
| » Starters: Billy O'Dell vs Steve Carlton | Fourth | 9 out |
| Monday, August 29 |
| » Lost to Reds (66-65), 2-0 | Crosley Field (3-5) | 67-64 | Lost 2 |
| » Starters: Larry Jaster vs Joe Nuxhall | Fourth | 9 out |
| Former Cardinal Bobby Schang dies in Sacramento, CA at the age of 80. |
| Tuesday, August 30 |
| » Lost to Reds (67-65), 6-4 | Crosley Field (3-6) | 67-65 | Lost 3 |
| » Starters: Al Jackson vs Sammy Ellis | Fourth | 10 out |
| Wednesday, August 31 |
| » Lost to Braves (63-68), 8-5 | Busch Stadium II (29-25) | 67-66 | Lost 4 |
| » Starters: Ken Johnson vs Bob Gibson | Fifth | 11 out |
| Thursday, September 1 |
| » Defeated Braves (63-69), 7-4 | Busch Stadium II (30-25) | 68-66 | |
| » Starters: Dick Kelley vs Steve Carlton | Fourth | 10 out |
| Friday, September 2 |
| » Defeated Giants (78-57), 6-5 | Busch Stadium II (31-25) | 69-66 | Won 2 |
| » Starters: Joe Gibbon vs Ray Washburn | Fifth | 10 out |
| Saturday, September 3 |
| » Defeated Giants (78-58), 3-2 | Busch Stadium II (32-25) | 70-66 | Won 3 |
| » Starters: Bobby Bolin vs Larry Jaster | Fifth | 10 out |
| Sunday, September 4 |
| » Lost to Giants (79-58), 9-2 | Busch Stadium II (32-26) | 70-67 | |
| » Starters: Juan Marichal vs Al Jackson | Fifth | 11 out |
| Monday, September 5 |
| » Defeated Astros (61-79), 4-1 | Busch Stadium II (33-26) | 71-67 | |
| » Starters: Turk Farrell vs Bob Gibson | Fifth | 11 out |
| » Lost to Astros (62-79), 6-0 | Busch Stadium II (33-27) | 71-68 | |
| » Starters: Larry Dierker vs Steve Carlton | Fifth | 11 out |
| Tuesday, September 6 |
| » Lost to Astros (63-79), 4-3 | Busch Stadium II (33-28) | 71-69 | Lost 2 |
| » Starters: Chris Zachary vs Nelson Briles | Fifth | 11 out |
| Wednesday, September 7 |
| » Defeated Astros (63-80), 6-5 | Busch Stadium II (34-28) | 72-69 | |
| » Starters: Dave Giusti vs Larry Jaster | Fifth | 10 out |
| Friday, September 9 |
| » Lost to Pirates (83-59), 3-2 | Forbes Field (3-4) | 72-70 | |
| » Starters: Ray Washburn vs Woodie Fryman | Fifth | 11 out |
| Saturday, September 10 |
| » Defeated Pirates (83-60), 6-5 | Forbes Field (4-4) | 73-70 | |
| » Starters: Bob Gibson vs Vern Law | Fifth | 10 out |
| Sunday, September 11 |
| » Defeated Pirates (83-61), 4-3 | Forbes Field (5-4) | 74-70 | Won 2 |
| » Starters: Al Jackson vs Bob Veale | Fifth | 10 out |
| » Major-league debuts: Dick Hughes (Cardinals) |
| Tuesday, September 13 |
| » Defeated Reds (71-73), 3-2 | Busch Stadium II (35-28) | 75-70 | Won 3 |
| » Starters: Jim O'Toole vs Larry Jaster | Fifth | 10½ out |
| Wednesday, September 14 |
| » Defeated Reds (71-74), 6-2 | Busch Stadium II (36-28) | 76-70 | Won 4 |
| » Starters: Sammy Ellis vs Ray Washburn | Fifth | 10 out |
| Friday, September 16 |
| » Defeated Cubs (53-94), 3-1 | Wrigley Field (5-1) | 77-70 | Won 5 |
| » Starters: Bob Gibson vs Curt Simmons | Fifth | 10 out |
| » Defeated Cubs (53-95), 4-0 | Wrigley Field (6-1) | 78-70 | Won 6 |
| » Starters: Al Jackson vs Rich Nye | Fifth | 10 out |
| » Major-league debuts: Rich Nye (Cubs) |
| Saturday, September 17 |
| » Defeated Cubs (53-96), 6-5 | Wrigley Field (7-1) | 79-70 | Won 7 |
| » Starters: Dick Hughes vs Ken Holtzman | Fourth | 9 out |
| Sunday, September 18 |
| » Lost to Cubs (54-96), 3-2 | Wrigley Field (7-2) | 79-71 | |
| » Starters: Larry Jaster vs Dick Ellsworth | Fifth | 9 out |
| Monday, September 19 |
| » Major-league debuts: Don Bosch (Pirates) |
| Tuesday, September 20 |
| » Lost to Braves (80-71), 5-1 | Atlanta-Fulton County Stadium (4-4) | 79-72 | Lost 2 |
| » Starters: Ray Washburn vs Tony Cloninger | Sixth | 10½ out |
| » Major-league debuts: Bill Robinson (Braves) Ron Willis (Cardinals) |
| Wednesday, September 21 |
| » Lost to Braves (81-71), 4-0 | Atlanta-Fulton County Stadium (4-5) | 79-73 | Lost 3 |
| » Starters: Bob Gibson vs Dick Kelley | Sixth | 10½ out |
| Friday, September 23 |
| » Lost to Phillies (82-72), 5-4 | Shibe Park (3-4) | 79-74 | Lost 4 |
| » Starters: Larry Jaster vs Larry Jackson | Fifth | 12 out |
| Saturday, September 24 |
| » Lost to Phillies (83-72), 5-4 | Shibe Park (3-5) | 79-75 | Lost 5 |
| » Starters: Al Jackson vs Jim Bunning | Sixth | 12 out |
| Future Cardinal Bernard Gilkey is born in St. Louis, MO. |
| Sunday, September 25 |
| » Lost to Phillies (84-72), 4-3 | Shibe Park (3-6) |
