| Tuesday, January 25 |
| Future Athletic Richie Lewis is born in Muncie, IN. |
| Monday, January 31 |
| Former Athletic Pat Donahue dies in Springfield, OH at the age of 82. |
| Monday, March 21 |
| Future Athletic Roger Smithberg is born in Elgin, IL. |
| Friday, March 25 |
| Former Athletic Bill Morrisette dies in Virginia Beach, VA at the age of 74. |
| Tuesday, April 12 |
| » Lost to Twins (1-0), 2-1 | Metropolitan Stadium (0-1) | 0-1 | |
| » Starters: Catfish Hunter vs Mudcat Grant | Second | 1 out |
| Wednesday, April 13 |
| » Lost to Twins (2-0), 5-3 | Metropolitan Stadium (0-2) | 0-2 | Lost 2 |
| » Starters: Rollie Sheldon vs Camilo Pascual | Fourth | 2 out |
| Thursday, April 14 |
| » Lost to Twins (3-0), 4-2 | Metropolitan Stadium (0-3) | 0-3 | Lost 3 |
| » Starters: Fred Talbot vs Jim Kaat | Seventh | 3 out |
| Future Athletic Greg Myers is born in Riverside, CA. |
| Saturday, April 16 |
| » Lost to White Sox (2-1), 2-1 | Comiskey Park I (0-1) | 0-4 | Lost 4 |
| » Starters: Catfish Hunter vs Gary Peters | Eighth | 4½ out |
| Sunday, April 17 |
| » Lost to White Sox (3-1), 5-0 | Comiskey Park I (0-2) | 0-5 | Lost 5 |
| » Starters: Rollie Sheldon vs John Buzhardt | Eighth | 4½ out |
| Tuesday, April 19 |
| » Defeated Twins (3-3), 3-2 | Municipal Stadium (1-0) | 1-5 | |
| » Starters: Camilo Pascual vs Chuck Dobson | Eighth | 4½ out |
| Thursday, April 21 |
| » Major-league debuts: Jorge Rubio (Angels) |
| Saturday, April 23 |
| » Defeated White Sox (5-3), 2-1 | Municipal Stadium (2-0) | 2-5 | Won 2 |
| » Starters: John Buzhardt vs Catfish Hunter | Seventh | 5 out |
| » Major-league debuts: Lee Elia (White Sox) |
| Sunday, April 24 |
| » Lost to White Sox (6-3), 4-3 | Municipal Stadium (2-1) | 2-6 | |
| » Starters: Gary Peters vs Fred Talbot | Seventh | 5½ out |
| Monday, April 25 |
| » Lost to Indians (8-0), 2-0 | Cleveland Stadium (0-1) | 2-7 | Lost 2 |
| » Starters: Rollie Sheldon vs Sam McDowell | Eighth | 6½ out |
| Tuesday, April 26 |
| » Lost to Indians (9-0), 4-0 | Cleveland Stadium (0-2) | 2-8 | Lost 3 |
| » Starters: Chuck Dobson vs Luis Tiant | Eighth | 7½ out |
| Thursday, April 28 |
| » Lost to Tigers (10-4), 13-5 | Tiger Stadium (0-1) | 2-9 | Lost 4 |
| » Starters: Catfish Hunter vs Mickey Lolich | Eighth | 8½ out |
| Saturday, April 30 |
| » Lost to Yankees (3-11), 6-0 | Yankee Stadium (0-1) | 2-10 | Lost 5 |
| » Starters: Fred Talbot vs Mel Stottlemyre | Tenth | 9 out |
| Sunday, May 1 |
| » Defeated Yankees (3-12), 1-0 | Yankee Stadium (1-1) | 3-10 | |
| » Starters: Rollie Sheldon vs Whitey Ford | Tenth | 9½ out |
| » Lost to Yankees (4-12), 10-4 | Yankee Stadium (1-2) | 3-11 | |
| » Starters: Chuck Dobson vs Fritz Peterson | Tenth | 9½ out |
| Tuesday, May 3 |
| » Lost to Angels (9-7), 6-2 | Anaheim Stadium (0-1) | 3-12 | Lost 2 |
| » Starters: Catfish Hunter vs Marcelino Lopez | Tenth | 10 out |
| Wednesday, May 4 |
| » Lost to Angels (10-7), 13-2 | Anaheim Stadium (0-2) | 3-13 | Lost 3 |
| » Starters: Fred Talbot vs Dean Chance | Tenth | 11 out |
| Thursday, May 5 |
| » Lost to Angels (11-7), 1-0 | Anaheim Stadium (0-3) | 3-14 | Lost 4 |
| » Starters: Rollie Sheldon vs Fred Newman | Tenth | 12 out |
| Friday, May 6 |
| » Defeated Senators (6-11), 2-1 | Municipal Stadium (3-1) | 4-14 | |
| » Starters: Pete Richert vs Chuck Dobson | Ninth | 11 out |
| Saturday, May 7 |
| » Defeated Senators (6-12), 5-2 | Municipal Stadium (4-1) | 5-14 | Won 2 |
| » Starters: Mike McCormick vs Catfish Hunter | Eighth | 11 out |
| Sunday, May 8 |
| » Lost to Senators (7-12), 3-2 | Municipal Stadium (4-2) | 5-15 | |
| » Starters: Phil Ortega vs Fred Talbot | Ninth | 10½ out |
| Monday, May 9 |
| » Defeated Red Sox (7-15), 6-1 | Municipal Stadium (5-2) | 6-15 | |
| » Starters: Pete Magrini vs Rollie Sheldon | Eighth | 10 out |
| Tuesday, May 10 |
| » Defeated Red Sox (7-16), 3-2 | Municipal Stadium (6-2) | 7-15 | Won 2 |
| » Starters: Dick Stigman vs Ralph Terry | Eighth | 10 out |
| Wednesday, May 11 |
| » Defeated Red Sox (7-17), 6-5 | Municipal Stadium (7-2) | 8-15 | Won 3 |
| » Starters: Jose Santiago vs Catfish Hunter | Eighth | 9 out |
| Thursday, May 12 |
| Future Athletic Rafael Bournigal is born in Azua, D.R. |
| Friday, May 13 |
| » Lost to Yankees (8-17), 4-2 | Municipal Stadium (7-3) | 8-16 | |
| » Starters: Whitey Ford vs Chuck Dobson | Eighth | 9½ out |
| Saturday, May 14 |
| » Defeated Yankees (8-18), 4-2 | Municipal Stadium (8-3) | 9-16 | |
| » Starters: Mel Stottlemyre vs Fred Talbot | Eighth | 9½ out |
| Sunday, May 15 |
| » Lost to Yankees (9-18), 5-2 | Municipal Stadium (8-4) | 9-17 | |
| » Starters: Al Downing vs Rollie Sheldon | Ninth | 10½ out |
| » Lost to Yankees (10-18), 3-1 | Municipal Stadium (8-5) | 9-18 | Lost 2 |
| » Starters: Bob Friend vs Ralph Terry | Ninth | 10½ out |
| Wednesday, May 18 |
| » Defeated Angels (17-13), 7-1 | Municipal Stadium (9-5) | 10-18 | |
| » Starters: Marcelino Lopez vs Catfish Hunter | Seventh | 9½ out |
| » Defeated Angels (17-14), 7-4 | Municipal Stadium (10-5) | 11-18 | Won 2 |
| » Starters: Dean Chance vs Chuck Dobson | Seventh | 9½ out |
| Friday, May 20 |
| » Lost to Red Sox (11-21), 3-0 | Fenway Park (0-1) | 11-19 | |
| » Starters: Fred Talbot vs Jose Santiago | Ninth | 10 out |
| Saturday, May 21 |
| » Lost to Red Sox (12-21), 6-5 | Fenway Park (0-2) | 11-20 | Lost 2 |
| » Starters: Rollie Sheldon vs Jerry Stephenson | Tenth | 10 out |
| Sunday, May 22 |
| » Lost to Red Sox (13-21), 5-1 | Fenway Park (0-3) | 11-21 | Lost 3 |
| » Starters: Ralph Terry vs Earl Wilson | Ninth | 11½ out |
| Monday, May 23 |
| » Defeated Senators (15-20), 5-3 | Robert F. Kennedy Stadium (1-0) | 12-21 | |
| » Starters: Catfish Hunter vs Mike McCormick | Tenth | 11 out |
| Tuesday, May 24 |
| » Lost to Senators (16-20), 2-1 | Robert F. Kennedy Stadium (1-1) | 12-22 | |
| » Starters: Chuck Dobson vs Phil Ortega | Tenth | 11½ out |
| Wednesday, May 25 |
| » Defeated Senators (16-21), 3-1 | Robert F. Kennedy Stadium (2-1) | 13-22 | |
| » Starters: Fred Talbot vs Diego Segui | Tenth | 11½ out |
| Friday, May 27 |
| » Lost to Orioles (22-15), 4-2 | Municipal Stadium (10-6) | 13-23 | |
| » Starters: Wally Bunker vs Rollie Sheldon | Tenth | 13 out |
| Future Athletic John Jaha is born in Portland, OR. |
| Saturday, May 28 |
| » Lost to Orioles (23-15), 9-2 | Municipal Stadium (10-7) | 13-24 | Lost 2 |
| » Starters: John Miller vs Ralph Terry | Tenth | 14 out |
| Sunday, May 29 |
| » Defeated Orioles (23-16), 6-3 | Municipal Stadium (11-7) | 14-24 | |
| » Starters: Jim Palmer vs Catfish Hunter | Tenth | 12½ out |
| Monday, May 30 |
| » Lost to Tigers (23-17), 5-2 | Municipal Stadium (11-8) | 14-25 | |
| » Starters: Denny McLain vs Chuck Dobson | Tenth | 12 out |
| Tuesday, May 31 |
| » Defeated Tigers (23-18), 7-1 | Municipal Stadium (12-8) | 15-25 | |
| » Starters: Bill Monbouquette vs Fred Talbot | Tenth | 12 out |
| Wednesday, June 1 |
| » Defeated Indians (28-15), 8-3 | Municipal Stadium (13-8) | 16-25 | Won 2 |
| » Starters: John O'Donoghue vs Rollie Sheldon | Tenth | 11 out |
| Thursday, June 2 |
| » Defeated Indians (28-16), 11-4 | Municipal Stadium (14-8) | 17-25 | Won 3 |
| » Starters: Gary Bell vs Ralph Terry | Ninth | 10 out |
| Friday, June 3 |
| » Lost to Orioles (28-17), 3-2 | Memorial Stadium (0-1) | 17-26 | |
| » Starters: Catfish Hunter vs Jim Palmer | Eighth | 11 out |
| Saturday, June 4 |
| » Lost to Orioles (29-17), 9-0 | Memorial Stadium (0-2) | 17-27 | Lost 2 |
| » Starters: Chuck Dobson vs Steve Barber | Ninth | 12½ out |
| » Lost to Orioles (30-17), 6-5 | Memorial Stadium (0-3) | 17-28 | Lost 3 |
| » Starters: Fred Talbot vs Dave McNally | Ninth | 12½ out |
| Sunday, June 5 |
| » Defeated Orioles (30-18), 9-4 | Memorial Stadium (1-3) | 18-28 | |
| » Starters: Rollie Sheldon vs Wally Bunker | Eighth | 11½ out |
| Tuesday, June 7 |
| » Lost to Twins (22-25), 6-1 | Metropolitan Stadium (0-4) | 18-29 | |
| » Starters: Rollie Sheldon vs Jim Kaat | Eighth | 11½ out |
| Wednesday, June 8 |
| » Defeated Twins (22-26), 5-4 | Metropolitan Stadium (1-4) | 19-29 | |
| » Starters: Fred Talbot vs Mudcat Grant | Eighth | 12 out |
| Thursday, June 9 |
| » Lost to Twins (23-26), 9-4 | Metropolitan Stadium (1-5) | 19-30 | |
| » Starters: Catfish Hunter vs Camilo Pascual | Ninth | 13 out |
| Friday, June 10 |
| » Defeated Angels (26-27), 3-2 | Anaheim Stadium (1-3) | 20-30 | |
| » Starters: Chuck Dobson vs Dean Chance | Ninth | 13 out |
| Saturday, June 11 |
| » Lost to Angels (27-27), 4-3 | Anaheim Stadium (1-4) | 20-31 | |
| » Starters: Ralph Terry vs Jim McGlothlin | Eighth | 13 out |
| Sunday, June 12 |
| » Defeated Angels (27-28), 4-1 | Anaheim Stadium (2-4) | 21-31 | |
| » Starters: Rollie Sheldon vs Marcelino Lopez | Eighth | 13 out |
| Monday, June 13 |
| » Defeated Twins (26-27), 5-2 | Municipal Stadium (15-8) | 22-31 | Won 2 |
| » Starters: Camilo Pascual vs Catfish Hunter | Eighth | 13 out |
| » Lost to Twins (27-27), 6-1 | Municipal Stadium (15-9) | 22-32 | |
| » Starters: Jim Perry vs Paul Lindblad | Eighth | 13 out |
| Tuesday, June 14 |
| » Lost to Twins (28-27), 6-3 | Municipal Stadium (15-10) | 22-33 | Lost 2 |
| » Starters: Dave Boswell vs Chuck Dobson | Eighth | 14½ out |
| Wednesday, June 15 |
| » Defeated White Sox (26-30), 5-4 | Comiskey Park I (1-2) | 23-33 | |
| » Starters: Lew Krausse vs Gary Peters | Eighth | 14½ out |
| Thursday, June 16 |
| » Lost to White Sox (27-30), 6-4 | Comiskey Park I (1-3) | 23-34 | |
| » Starters: Bill Stafford vs Bruce Howard | Eighth | 15 out |
| » Lost to White Sox (28-30), 5-2 | Comiskey Park I (1-4) | 23-35 | Lost 2 |
| » Starters: Ralph Terry vs Juan Pizarro | Eighth | 15 out |
| Friday, June 17 |
| » Lost to Angels (33-29), 4-2 | Municipal Stadium (15-11) | 23-36 | Lost 3 |
| » Starters: Marcelino Lopez vs Catfish Hunter | Ninth | 16 out |
| Saturday, June 18 |
| » Lost to Angels (34-29), 7-3 | Municipal Stadium (15-12) | 23-37 | Lost 4 |
| » Starters: Dean Chance vs Chuck Dobson | Eighth | 17 out |
| Sunday, June 19 |
| » Defeated Angels (34-30), 1-0 | Municipal Stadium (16-12) | 24-37 | |
| » Starters: Clyde Wright vs Lew Krausse | Ninth | 16 out |
| » Defeated Angels (34-31), 3-2 | Municipal Stadium (17-12) | 25-37 | Won 2 |
| » Starters: Jim McGlothlin vs Paul Lindblad | Ninth | 16 out |
| Monday, June 20 |
| » Lost to White Sox (30-32), 3-1 | Municipal Stadium (17-13) | 25-38 | |
| » Starters: Joe Horlen vs Bill Stafford | Eighth | 16½ out |
| Tuesday, June 21 |
| » Defeated White Sox (30-33), 9-8 | Municipal Stadium (18-13) | 26-38 | |
| » Starters: Tommy John vs Ralph Terry | Eighth | 16 out |
| Wednesday, June 22 |
| » Lost to White Sox (31-33), 7-4 | Municipal Stadium (18-14) | 26-39 | |
| » Starters: Bruce Howard vs Catfish Hunter | Ninth | 16½ out |
| » Defeated White Sox (31-34), 3-1 | Municipal Stadium (19-14) | 27-39 | |
| » Starters: John Buzhardt vs Chuck Dobson | Ninth | 16½ out |
| Friday, June 24 |
| » Defeated Indians (40-25), 7-5 | Cleveland Stadium (1-2) | 28-39 | Won 2 |
| » Starters: Lew Krausse vs Jack Kralick | Seventh | 16 out |
| Saturday, June 25 |
| » Defeated Indians (40-26), 7-1 | Cleveland Stadium (2-2) | 29-39 | Won 3 |
| » Starters: Paul Lindblad vs Gary Bell | Eighth | 16 out |
| Sunday, June 26 |
| » Defeated Indians (40-27), 4-2 | Cleveland Stadium (3-2) | 30-39 | Won 4 |
| » Starters: Catfish Hunter vs Steve Hargan | Eighth | 16½ out |
| » Lost to Indians (41-27), 14-3 | Cleveland Stadium (3-3) | 30-40 | |
| » Starters: Bill Stafford vs Sonny Siebert | Eighth | 16½ out |
| Tuesday, June 28 |
| » Defeated Orioles (48-25), 4-3 | Municipal Stadium (20-14) | 31-40 | |
| » Starters: Jim Palmer vs Chuck Dobson | Eighth | 16 out |
| Wednesday, June 29 |
| » Lost to Orioles (49-25), 5-2 | Municipal Stadium (20-15) | 31-41 | |
| » Starters: Dave McNally vs Lew Krausse | Eighth | 17 out |
| Thursday, June 30 |
| » Lost to Orioles (50-25), 11-3 | Municipal Stadium (20-16) | 31-42 | Lost 2 |
| » Starters: Wally Bunker vs Ralph Terry | Eighth | 18 out |
| Friday, July 1 |
| » Lost to Tigers (45-27), 8-5 | Tiger Stadium (0-2) | 31-43 | Lost 3 |
| » Starters: Bill Stafford vs Denny McLain | Eighth | 19 out |
| » Defeated Tigers (45-28), 6-4 | Tiger Stadium (1-2) | 32-43 | |
| » Starters: Catfish Hunter vs Mickey Lolich | Eighth | 19 out |
| Saturday, July 2 |
| » Lost to Tigers (46-28), 7-3 | Tiger Stadium (1-3) | 32-44 | |
| » Starters: Paul Lindblad vs Earl Wilson | Eighth | 20½ out |
| Sunday, July 3 |
| » Defeated Tigers (46-29), 3-0 | Tiger Stadium (2-3) | 33-44 | |
| » Starters: Lew Krausse vs Dave Wickersham | Eighth | 20 out |
| » Defeated Tigers (46-30), 10-4 | Tiger Stadium (3-3) | 34-44 | Won 2 |
| » Starters: Jim Nash vs Hank Aguirre | Eighth | 20 out |
| Monday, July 4 |
| » Defeated Orioles (55-26), 9-6 | Memorial Stadium (2-3) | 35-44 | Won 3 |
| » Starters: Catfish Hunter vs Gene Brabender | Eighth | 19 out |
| Wednesday, July 6 |
| » Lost to Orioles (56-26), 11-0 | Memorial Stadium (2-4) | 35-45 | |
| » Starters: Bill Stafford vs Steve Barber | Seventh | 19 out |
| » Defeated Orioles (56-27), 9-8 | Memorial Stadium (3-4) | 36-45 | |
| » Starters: Paul Lindblad vs Wally Bunker | Seventh | 19 out |
| Friday, July 8 |
| » Defeated Indians (45-35), 2-1 | Municipal Stadium (21-16) | 37-45 | Won 2 |
| » Starters: Sonny Siebert vs Lew Krausse | Seventh | 19 out |
| Saturday, July 9 |
| » Lost to Indians (46-35), 6-3 | Municipal Stadium (21-17) | 37-46 | |
| » Starters: Gary Bell vs Catfish Hunter | Seventh | 19½ out |
| Sunday, July 10 |
| » Defeated Indians (46-36), 4-1 | Municipal Stadium (22-17) | 38-46 | |
| » Starters: Sam McDowell vs Jim Nash | Sixth | 18 out |
| » Defeated Indians (46-37), 5-3 | Municipal Stadium (23-17) | 39-46 | Won 2 |
| » Starters: Steve Hargan vs Bill Stafford | Sixth | 18 out |
| Thursday, July 14 |
| » Lost to Yankees (37-48), 5-4 | Municipal Stadium (23-18) | 39-47 | |
| » Starters: Al Downing vs Catfish Hunter | Sixth | 18 out |
| Friday, July 15 |
| » Defeated Yankees (37-49), 5-4 | Municipal Stadium (24-18) | 40-47 | |
| » Starters: Mel Stottlemyre vs Lew Krausse | Sixth | 17 out |
| Saturday, July 16 |
| » Lost to Yankees (38-49), 9-5 | Municipal Stadium (24-19) | 40-48 | |
| » Starters: Fritz Peterson vs Paul Lindblad | Seventh | 18 out |
| Sunday, July 17 |
| » Defeated Red Sox (38-55), 3-2 | Municipal Stadium (25-19) | 41-48 | |
| » Starters: Rollie Sheldon vs Jim Nash | Seventh | 18 out |
| » Lost to Red Sox (39-55), 3-2 | Municipal Stadium (25-20) | 41-49 | |
| » Starters: Lee Stange vs Bill Stafford | Seventh | 18 out |
| Wednesday, July 20 |
| » Lost to Yankees (42-49), 4-0 | Yankee Stadium (1-3) | 41-50 | Lost 2 |
| » Starters: Catfish Hunter vs Mel Stottlemyre | Eighth | 20 out |
| Thursday, July 21 |
| » Lost to Yankees (43-49), 4-3 | Yankee Stadium (1-4) | 41-51 | Lost 3 |
| » Starters: Lew Krausse vs Fritz Peterson | Eighth | 21 out |
| Friday, July 22 |
| » Defeated Senators (40-58), 7-2 | Robert F. Kennedy Stadium (3-1) | 42-51 | |
| » Starters: Jim Nash vs Diego Segui | Eighth | 21 out |
| Saturday, July 23 |
| » Lost to Senators (41-58), 8-1 | Robert F. Kennedy Stadium (3-2) | 42-52 | |
| » Starters: Bill Stafford vs Barry Moore | Eighth | 22 out |
| Sunday, July 24 |
| » Lost to Senators (42-58), 6-2 | Robert F. Kennedy Stadium (3-3) | 42-53 | Lost 2 |
| » Starters: Catfish Hunter vs Pete Richert | Eighth | 22½ out |
| » Lost to Senators (43-58), 7-4 | Robert F. Kennedy Stadium (3-4) | 42-54 | Lost 3 |
| » Starters: Jim Dickson vs Phil Ortega | Eighth | 22½ out |
| Tuesday, July 26 |
| » Lost to Red Sox (43-58), 8-5 | Fenway Park (0-4) | 42-55 | Lost 4 |
| » Starters: Lew Krausse vs Dennis Bennett | Eighth | 22½ out |
| Wednesday, July 27 |
| » Defeated Red Sox (43-59), 14-2 | Fenway Park (1-4) | 43-55 | |
| » Starters: Jim Nash vs Jose Santiago | Eighth | 22½ out |
| Friday, July 29 |
| » Defeated Tigers (53-46), 4-1 | Municipal Stadium (26-20) | 44-55 | Won 2 |
| » Starters: Johnny Podres vs Lew Krausse | Eighth | 22½ out |
| Saturday, July 30 |
| » Defeated Tigers (53-47), 2-1 | Municipal Stadium (27-20) | 45-55 | Won 3 |
| » Starters: Mickey Lolich vs Blue Moon Odom | Eighth | 21½ out |
| Sunday, July 31 |
| » Lost to Tigers (54-47), 5-4 | Municipal Stadium (27-21) | 45-56 | |
| » Starters: Bill Monbouquette vs Jim Nash | Eighth | 23 out |
| » Lost to Tigers (55-47), 7-1 | Municipal Stadium (27-22) | 45-57 | Lost 2 |
| » Starters: Earl Wilson vs Gil Blanco | Eighth | 23 out |
| Monday, August 1 |
| » Lost to Senators (48-61), 6-4 | Municipal Stadium (27-23) | 45-58 | Lost 3 |
| » Starters: Barry Moore vs Ralph Terry | Ninth | 23½ out |
| Tuesday, August 2 |
| » Defeated Senators (48-62), 4-3 | Municipal Stadium (28-23) | 46-58 | |
| » Starters: Frank Kreutzer vs Lew Krausse | Eighth | 23½ out |
| Wednesday, August 3 |
| » Lost to Senators (49-62), 4-3 | Municipal Stadium (28-24) | 46-59 | |
| » Starters: Pete Richert vs Blue Moon Odom | Ninth | 23½ out |
| Thursday, August 4 |
| » Defeated Senators (49-63), 4-3 | Municipal Stadium (29-24) | 47-59 | |
| » Starters: Phil Ortega vs Jim Nash | Eighth | 22½ out |
| Friday, August 5 |
| » Defeated Twins (55-53), 4-2 | Municipal Stadium (30-24) | 48-59 | Won 2 |
| » Starters: Jim Merritt vs Gil Blanco | Eighth | 21½ out |
| Saturday, August 6 |
| » Lost to Twins (56-53), 5-0 | Municipal Stadium (30-25) | 48-60 | |
| » Starters: Mudcat Grant vs Lew Krausse | Eighth | 22½ out |
| Sunday, August 7 |
| » Lost to Twins (57-53), 2-1 | Municipal Stadium (30-26) | 48-61 | Lost 2 |
| » Starters: Dave Boswell vs Blue Moon Odom | Eighth | 22 out |
| » Defeated Twins (57-54), 4-2 | Municipal Stadium (31-26) | 49-61 | |
| » Starters: Jim Perry vs Paul Lindblad | Eighth | 22 out |
| Monday, August 8 |
| » Defeated Twins (57-55), 6-1 | Municipal Stadium (32-26) | 50-61 | Won 2 |
| » Starters: Jim Kaat vs Jim Nash | Seventh | 21½ out |
| Tuesday, August 9 |
| » Lost to White Sox (56-55), 2-1 | Municipal Stadium (32-27) | 50-62 | |
| » Starters: Bruce Howard vs Gil Blanco | Eighth | 21½ out |
| Wednesday, August 10 |
| » Lost to White Sox (57-55), 9-2 | Municipal Stadium (32-28) | 50-63 | Lost 2 |
| » Starters: Gary Peters vs Lew Krausse | Eighth | 22½ out |
| Thursday, August 11 |
| » Lost to White Sox (58-55), 10-9 | Municipal Stadium (32-29) | 50-64 | Lost 3 |
| » Starters: John Buzhardt vs Blue Moon Odom | Eighth | 23½ out |
| Friday, August 12 |
| » Lost to Twins (60-56), 6-2 | Metropolitan Stadium (1-6) | 50-65 | Lost 4 |
| » Starters: Paul Lindblad vs Jim Perry | Ninth | 24 out |
| Sunday, August 14 |
| » Defeated Twins (60-57), 5-0 | Metropolitan Stadium (2-6) | 51-65 | |
| » Starters: Jim Nash vs Mudcat Grant | Seventh | 24 out |
| » Defeated Twins (60-58), 4-3 | Metropolitan Stadium (3-6) | 52-65 | Won 2 |
| » Starters: Gil Blanco vs Jim Merritt | Seventh | 24 out |
| Future Athletic Dana Allison is born in Front Royal, VA. |
| Monday, August 15 |
| » Lost to White Sox (61-57), 4-3 | Comiskey Park I (1-5) | 52-66 | |
| » Starters: Lew Krausse vs Joe Horlen | Eighth | 25 out |
| Future Athletic Scott Brosius is born in Hillsboro, OR. |
| Tuesday, August 16 |
| » Defeated White Sox (61-58), 4-2 | Comiskey Park I (2-5) | 53-66 | |
| » Starters: Blue Moon Odom vs Tommy John | Seventh | 25 out |
| Wednesday, August 17 |
| » Lost to White Sox (62-58), 4-2 | Comiskey Park I (2-6) | 53-67 | |
| » Starters: Paul Lindblad vs John Buzhardt | Sixth | 26½ out |
| » Lost to White Sox (63-58), 5-1 | Comiskey Park I (2-7) | 53-68 | Lost 2 |
| » Starters: Vern Handrahan vs Jack Lamabe | Sixth | 26½ out |
| Friday, August 19 |
| » Lost to Yankees (54-68), 7-5 | Yankee Stadium (1-5) | 53-69 | Lost 3 |
| » Starters: Jim Nash vs Fred Talbot | Seventh | 26 out |
| » Defeated Yankees (54-69), 1-0 | Yankee Stadium (2-5) | 54-69 | |
| » Starters: Lew Krausse vs Fritz Peterson | Seventh | 26 out |
| Saturday, August 20 |
| » Lost to Yankees (55-69), 8-5 | Yankee Stadium (2-6) | 54-70 | |
| » Starters: Gil Blanco vs Mel Stottlemyre | Seventh | 27 out |
| Sunday, August 21 |
| » Lost to Yankees (56-69), 7-3 | Yankee Stadium (2-7) | 54-71 | Lost 2 |
| » Starters: Blue Moon Odom vs Al Downing | Eighth | 27 out |
| Wednesday, August 24 |
| » Defeated Red Sox (54-75), 4-2 | Fenway Park (2-4) | 55-71 | |
| » Starters: Jim Nash vs Bucky Brandon | Eighth | 25 out |
| » Defeated Red Sox (54-76), 8-3 | Fenway Park (3-4) | 56-71 | Won 2 |
| » Starters: Lew Krausse vs Jose Santiago | Eighth | 25 out |
| Thursday, August 25 |
| » Lost to Red Sox (55-76), 8-6 | Fenway Park (3-5) | 56-72 | |
| » Starters: Blue Moon Odom vs Dennis Bennett | Ninth | 26½ out |
| » Lost to Red Sox (56-76), 4-1 | Fenway Park (3-6) | 56-73 | Lost 2 |
| » Starters: Paul Lindblad vs Hank Fischer | Ninth | 26½ out |
| Friday, August 26 |
| » Lost to Angels (65-63), 5-4 | Anaheim Stadium (2-5) | 56-74 | Lost 3 |
| » Starters: Gil Blanco vs Jim Coates | Eighth | 27½ out |
| Saturday, August 27 |
| » Lost to Angels (66-63), 6-5 | Anaheim Stadium (2-6) | 56-75 | Lost 4 |
| » Starters: Ken Sanders vs Dean Chance | Ninth | 27½ out |
| Sunday, August 28 |
| » Defeated Angels (66-64), 2-1 | Anaheim Stadium (3-6) | 57-75 | |
| » Starters: Jim Nash vs Fred Newman | Ninth | 26½ out |
| Monday, August 29 |
| » Lost to Yankees (60-72), 7-2 | Municipal Stadium (32-30) | 57-76 | |
| » Starters: Fred Talbot vs Lew Krausse | Tenth | 26½ out |
| Tuesday, August 30 |
| » Defeated Yankees (60-73), 4-1 | Municipal Stadium (33-30) | 58-76 | |
| » Starters: Mel Stottlemyre vs Blue Moon Odom | Tenth | 25½ out |
| Wednesday, August 31 |
| » Lost to Senators (62-75), 3-0 | Municipal Stadium (33-31) | 58-77 | |
| » Starters: Mike McCormick vs Gil Blanco | Tenth | 26 out |
| » Defeated Senators (62-76), 4-0 | Municipal Stadium (34-31) | 59-77 | |
| » Starters: Barry Moore vs Paul Lindblad | Tenth | 26 out |
| Friday, September 2 |
| » Defeated Red Sox (60-79), 5-1 | Municipal Stadium (35-31) | 60-77 | Won 2 |
| » Starters: Hank Fischer vs Lew Krausse | Ninth | 24½ out |
| Saturday, September 3 |
| » Lost to Red Sox (61-79), 7-0 | Municipal Stadium (35-32) | 60-78 | |
| » Starters: Jim Lonborg vs Catfish Hunter | Tenth | 25½ out |
| » Major-league debuts: Rick Monday (Athletics) |
| Sunday, September 4 |
| » Lost to Red Sox (62-79), 3-0 | Municipal Stadium (35-33) | 60-79 | Lost 2 |
| » Starters: Bucky Brandon vs Blue Moon Odom | Tenth | 26 out |
| » Defeated Red Sox (62-80), 7-2 | Municipal Stadium (36-33) | 61-79 | |
| » Starters: Jose Santiago vs Gil Blanco | Tenth | 26 out |
| Monday, September 5 |
| » Defeated Angels (69-69), 4-1 | Municipal Stadium (37-33) | 62-79 | Won 2 |
| » Starters: Marcelino Lopez vs Jim Nash | Eighth | 26½ out |
| Tuesday, September 6 |
| » Lost to Angels (70-69), 4-3 | Municipal Stadium (37-34) | 62-80 | |
| » Starters: Fred Newman vs Paul Lindblad | Eighth | 27½ out |
| Wednesday, September 7 |
| » Defeated Angels (70-70), 6-3 | Municipal Stadium (38-34) | 63-80 | |
| » Starters: George Brunet vs Lew Krausse | Seventh | 27½ out |
| Friday, September 9 |
| » Defeated Tigers (79-63), 2-1 | Municipal Stadium (39-34) | 64-80 | Won 2 |
| » Starters: Johnny Podres vs Blue Moon Odom | Seventh | 26½ out |
| Saturday, September 10 |
| » Defeated Tigers (79-64), 5-0 | Municipal Stadium (40-34) | 65-80 | Won 3 |
| » Starters: Denny McLain vs Jim Nash | Seventh | 25½ out |
| » Major-league debuts: George Korince (Tigers) |
| Sunday, September 11 |
| » Defeated Tigers (79-65), 5-1 | Municipal Stadium (41-34) | 66-80 | Won 4 |
| » Starters: Earl Wilson vs Lew Krausse | Seventh | 24½ out |
| Tuesday, September 13 |
| » Defeated Indians (73-74), 3-1 | Cleveland Stadium (4-3) | 67-80 | Won 5 |
| » Starters: Paul Lindblad vs Steve Hargan | Seventh | 23½ out |
| Wednesday, September 14 |
| » Defeated Indians (73-75), 3-0 | Cleveland Stadium (5-3) | 68-80 | Won 6 |
| » Starters: Blue Moon Odom vs Sam McDowell | Seventh | 23 out |
| Thursday, September 15 |
| » Defeated Indians (73-76), 1-0 | Cleveland Stadium (6-3) | 69-80 | Won 7 |
| » Starters: Bill Edgerton vs Sonny Siebert | Seventh | 23½ out |
| Friday, September 16 |
| » Game at Robert F. Kennedy Stadium interrupted in the 3rd inning with the score of Athletics 0, Senators 0. Completed on September 18. |
| Sunday, September 18 |
| » Defeated Senators (66-86), 3-0 | Robert F. Kennedy Stadium (4-4) | 70-80 | Won 8 |
| » Starters: Lew Krausse vs Barry Moore | Seventh | 22 out |
| » Lost to Senators (67-86), 1-0 | Robert F. Kennedy Stadium (4-5) | 70-81 | |
| » Starters: Blue Moon Odom vs Phil Ortega | Seventh | 22 out |
| Tuesday, September 20 |
| » Lost to Orioles (93-58), 4-0 | Municipal Stadium (41-35) | 70-82 | Lost 2 |
| » Starters: Tom Phoebus vs Catfish Hunter | Seventh | 23½ out |
| Wednesday, September 21 |
| » Lost to Orioles (94-58), 10-8 | Municipal Stadium (41-36) | 70-83 | Lost 3 |
| » Starters: Dave McNally vs Jim Nash | Seventh | 24½ out |
| Thursday, September 22 |
| » Lost to Orioles (95-58), 6-1 | Municipal Stadium (41-37) | 70-84 | Lost 4 |
| » Starters: Jim Palmer vs Lew Krausse | Seventh | 25½ out |
| Friday, September 23 |
| » Defeated Indians (77-78), 2-0 | Municipal Stadium (42-37) | 71-84 | |
| » Starters: Gary Bell vs Blue Moon Odom | Seventh | 24½ out |
| Saturday, September 24 |
| » Lost to Indians (78-78), 3-1 | Municipal Stadium (42-38) | 71-85 | |
| » Starters: Luis Tiant vs Paul Lindblad | Seventh | 25½ out |
| Sunday, September 25 |
| » Lost to Indians (79-78), 4-2 | Municipal Stadium (42-39) | 71-86 | Lost 2 |
| » Starters: Steve Hargan vs Jim Nash | Seventh | 25½ out |
| Friday, September 30 |
| » Defeated Tigers (88-72), 8-5 | Tiger Stadium (4-3) | 72-86 | |
| » Starters: Blue Moon Odom vs Earl Wilson | Sixth | 24 out |
| Saturday, October 1 |
| » Defeated Tigers (88-73), 5-2 | Tiger Stadium (5-3) | 73-86 | Won 2 |
| » Starters: Jim Nash vs Denny McLain | Seventh | 23½ out |
| Sunday, October 2 |
| » Defeated Tigers (88-74), 7-5 | Tiger Stadium (6-3) | 74-86 | Won 3 |
| » Starters: Catfish Hunter vs Johnny Podres | Seventh | 23 out |
| Tuesday, October 25 |
| Future Athletic Mike Harkey is born in San Diego, CA. |
| Monday, November 7 |
| Future Athletic Andy Tomberlin is born in Monroe, NC. |
| Friday, November 11 |
|
