| Tuesday, January 19 |
| Former White Sox Jim Joe Edwards dies in Sarepta, MS at the age of 71. |
| Thursday, January 21 |
| Future White Sox Matt Stark is born in Whittier, CA. |
| Tuesday, January 26 |
| Future White Sox Lou Frazier is born in St. Louis, MO. |
| Thursday, January 28 |
| Former White Sox Billy Sullivan dies in Newberg, OR at the age of 90. |
| Saturday, January 30 |
| Future White Sox Joel Davis is born in Jacksonville, FL. |
| Thursday, March 25 |
| Future White Sox Jerry Kutzler is born in Waukegan, IL. |
| Tuesday, April 13 |
| » Defeated Orioles (0-1), 5-3 | Memorial Stadium (1-0) | 1-0 | |
| » Starters: Gary Peters vs Steve Barber | Second | ½ out |
| » Major-league debuts: Davey Johnson (Orioles) |
| Wednesday, April 14 |
| » Lost to Orioles (1-1), 6-0 | Memorial Stadium (1-1) | 1-1 | |
| » Starters: Joe Horlen vs Milt Pappas | Third | 1 out |
| » Major-league debuts: Curt Blefary (Orioles) |
| Thursday, April 15 |
| » Lost to Senators (2-1), 3-1 | Comiskey Park I (0-1) | 1-2 | Lost 2 |
| » Starters: Bennie Daniels vs John Buzhardt | Fourth | 2 out |
| Saturday, April 17 |
| » Defeated Senators (2-2), 2-1 | Comiskey Park I (1-1) | 2-2 | |
| » Starters: Phil Ortega vs Bruce Howard | Third | 1 out |
| Sunday, April 18 |
| » Defeated Senators (2-3), 5-1 | Comiskey Park I (2-1) | 3-2 | Won 2 |
| » Starters: Frank Kreutzer vs Gary Peters | Fourth | 1½ out |
| » Lost to Senators (3-3), 4-1 | Comiskey Park I (2-2) | 3-3 | |
| » Starters: Pete Richert vs Joe Horlen | Fourth | 1½ out |
| Monday, April 19 |
| » Defeated Orioles (1-4), 7-2 | Comiskey Park I (3-2) | 4-3 | |
| » Starters: Milt Pappas vs Tommy John | Third | 1½ out |
| Wednesday, April 21 |
| » Defeated Red Sox (4-2), 3-1 | Fenway Park (1-0) | 5-3 | Won 2 |
| » Starters: John Buzhardt vs Bill Monbouquette | Fourth | 1½ out |
| Friday, April 23 |
| » Defeated Senators (3-7), 5-3 | Robert F. Kennedy Stadium (1-0) | 6-3 | Won 3 |
| » Starters: Juan Pizarro vs Pete Richert | Second | 1 out |
| Saturday, April 24 |
| » Defeated Senators (3-8), 6-2 | Robert F. Kennedy Stadium (2-0) | 7-3 | Won 4 |
| » Starters: Bruce Howard vs Buster Narum | Second | 1 out |
| Tuesday, April 27 |
| » Defeated Red Sox (5-4), 10-1 | Comiskey Park I (4-2) | 8-3 | Won 5 |
| » Starters: Bill Monbouquette vs John Buzhardt | Second | 1 out |
| Friday, April 30 |
| » Lost to Twins (8-3), 7-0 | Comiskey Park I (4-3) | 8-4 | |
| » Starters: Mudcat Grant vs Gary Peters | Second | ½ out |
| Saturday, May 1 |
| » Defeated Twins (8-4), 2-1 | Comiskey Park I (5-3) | 9-4 | |
| » Starters: Camilo Pascual vs Joe Horlen | First | -- |
| Sunday, May 2 |
| » Lost to Twins (9-4), 3-2 | Comiskey Park I (5-4) | 9-5 | |
| » Starters: Jim Kaat vs Tommy John | First | -- |
| » Defeated Twins (9-5), 5-4 | Comiskey Park I (6-4) | 10-5 | |
| » Starters: Dave Boswell vs Bruce Howard | First | -- |
| Tuesday, May 4 |
| » Defeated Tigers (9-7), 10-6 | Tiger Stadium (1-0) | 11-5 | Won 2 |
| » Starters: Gary Peters vs Denny McLain | First | -- |
| Wednesday, May 5 |
| » Defeated Tigers (9-8), 4-0 | Tiger Stadium (2-0) | 12-5 | Won 3 |
| » Starters: John Buzhardt vs Mickey Lolich | First | -- |
| » Defeated Tigers (9-9), 4-1 | Tiger Stadium (3-0) | 13-5 | Won 4 |
| » Starters: Joe Horlen vs Dave Wickersham | First | -- |
| Friday, May 7 |
| » Defeated Twins (11-7), 13-5 | Metropolitan Stadium (1-0) | 14-5 | Won 5 |
| » Starters: Tommy John vs Dick Stigman | First | -- |
| Saturday, May 8 |
| » Lost to Twins (12-7), 4-1 | Metropolitan Stadium (1-1) | 14-6 | |
| » Starters: Gary Peters vs Mudcat Grant | First | -- |
| Sunday, May 9 |
| » Lost to Twins (13-7), 6-1 | Metropolitan Stadium (1-2) | 14-7 | Lost 2 |
| » Starters: Bruce Howard vs Camilo Pascual | First | -- |
| » Major-league debuts: Greg Bollo (White Sox) |
| Monday, May 10 |
| » Lost to Twins (14-7), 4-3 | Metropolitan Stadium (1-3) | 14-8 | Lost 3 |
| » Starters: Joe Horlen vs Jim Kaat | Second | ½ out |
| Wednesday, May 12 |
| » Defeated Athletics (5-17), 7-4 | Comiskey Park I (7-4) | 15-8 | |
| » Starters: Fred Talbot vs Juan Pizarro | Second | ½ out |
| » Defeated Athletics (5-18), 6-4 | Comiskey Park I (8-4) | 16-8 | Won 2 |
| » Starters: Rollie Sheldon vs John Buzhardt | Second | ½ out |
| Thursday, May 13 |
| » Defeated Athletics (5-19), 6-3 | Comiskey Park I (9-4) | 17-8 | Won 3 |
| » Starters: Diego Segui vs Gary Peters | First | -- |
| » Major-league debuts: Catfish Hunter (Athletics) |
| Friday, May 14 |
| » Defeated Angels (16-12), 2-1 | Comiskey Park I (10-4) | 18-8 | Won 4 |
| » Starters: Marcelino Lopez vs Joe Horlen | First | -- |
| Future White Sox Joey Cora is born in Caguas, P.R. Former White Sox Lee Quillen dies in St.Paul, MN at the age of 84. |
| Saturday, May 15 |
| » Defeated Angels (16-13), 8-3 | Comiskey Park I (11-4) | 19-8 | Won 5 |
| » Starters: Dean Chance vs Bruce Howard | First | -- |
| Future White Sox Isidro Marquez is born in Navojoa, Mexico. |
| Sunday, May 16 |
| » Defeated Angels (16-14), 6-2 | Comiskey Park I (12-4) | 20-8 | Won 6 |
| » Starters: Rudy May vs John Buzhardt | First | -- |
| » Defeated Angels (16-15), 5-4 | Comiskey Park I (13-4) | 21-8 | Won 7 |
| » Starters: George Brunet vs Tommy John | First | -- |
| Monday, May 17 |
| » Defeated Athletics (7-22), 13-2 | Municipal Stadium (1-0) | 22-8 | Won 8 |
| » Starters: Gary Peters vs Rollie Sheldon | First | -- |
| Tuesday, May 18 |
| » Defeated Athletics (7-23), 5-4 | Municipal Stadium (2-0) | 23-8 | Won 9 |
| » Starters: Joe Horlen vs Orlando Pena | First | -- |
| Wednesday, May 19 |
| » Lost to Athletics (8-23), 7-3 | Municipal Stadium (2-1) | 23-9 | |
| » Starters: Bruce Howard vs John O'Donoghue | First | -- |
| Friday, May 21 |
| » Lost to Angels (19-17), 1-0 | Dodger Stadium (0-1) | 23-10 | Lost 2 |
| » Starters: Tommy John vs Fred Newman | First | -- |
| Saturday, May 22 |
| » Lost to Angels (20-17), 6-3 | Dodger Stadium (0-2) | 23-11 | Lost 3 |
| » Starters: Gary Peters vs Marcelino Lopez | First | -- |
| Sunday, May 23 |
| » Defeated Angels (20-18), 8-3 | Dodger Stadium (1-2) | 24-11 | |
| » Starters: Joe Horlen vs Dean Chance | First | -- |
| Former White Sox Earl Webb dies in Jamestown, TN at the age of 68. |
| Monday, May 24 |
| » Lost to Tigers (20-17), 8-3 | Comiskey Park I (13-5) | 24-12 | |
| » Starters: Mickey Lolich vs John Buzhardt | First | -- |
| Tuesday, May 25 |
| » Lost to Tigers (21-17), 7-5 | Comiskey Park I (13-6) | 24-13 | Lost 2 |
| » Starters: Dave Wickersham vs Tommy John | First | -- |
| Wednesday, May 26 |
| » Lost to Indians (19-17), 3-1 | Comiskey Park I (13-7) | 24-14 | Lost 3 |
| » Starters: Luis Tiant vs Gary Peters | Second | 1 out |
| Friday, May 28 |
| » Defeated Yankees (17-24), 2-0 | Comiskey Park I (14-7) | 25-14 | |
| » Starters: Bill Stafford vs Joe Horlen | First | -- |
| Saturday, May 29 |
| » Defeated Yankees (17-25), 6-3 | Comiskey Park I (15-7) | 26-14 | Won 2 |
| » Starters: Al Downing vs Tommy John | First | -- |
| Sunday, May 30 |
| » Lost to Yankees (18-25), 3-2 | Comiskey Park I (15-8) | 26-15 | |
| » Starters: Mel Stottlemyre vs Gary Peters | Second | ½ out |
| Monday, May 31 |
| » Defeated Indians (20-20), 4-3 | Cleveland Stadium (1-0) | 27-15 | |
| » Starters: John Buzhardt vs Sonny Siebert | Second | ½ out |
| » Lost to Indians (21-20), 4-3 | Cleveland Stadium (1-1) | 27-16 | |
| » Starters: Juan Pizarro vs Luis Tiant | Second | ½ out |
| Friday, June 4 |
| » Defeated Yankees (19-27), 2-0 | Yankee Stadium (1-0) | 28-16 | |
| » Starters: Joe Horlen vs Bill Stafford | Second | 1½ out |
| Saturday, June 5 |
| » Lost to Yankees (20-27), 4-3 | Yankee Stadium (1-1) | 28-17 | |
| » Starters: Gary Peters vs Mel Stottlemyre | Second | 2 out |
| Sunday, June 6 |
| » Lost to Yankees (21-27), 6-1 | Yankee Stadium (1-2) | 28-18 | Lost 2 |
| » Starters: Tommy John vs Whitey Ford | Second | 3½ out |
| » Lost to Yankees (22-27), 12-0 | Yankee Stadium (1-3) | 28-19 | Lost 3 |
| » Starters: Juan Pizarro vs Al Downing | Second | 3½ out |
| Monday, June 7 |
| » Defeated Red Sox (23-26), 7-3 | Fenway Park (2-0) | 29-19 | |
| » Starters: John Buzhardt vs Jim Lonborg | Second | 2½ out |
| Tuesday, June 8 |
| » Defeated Red Sox (23-27), 7-2 | Fenway Park (3-0) | 30-19 | Won 2 |
| » Starters: Joe Horlen vs Bill Monbouquette | Second | 2½ out |
| Wednesday, June 9 |
| » Lost to Red Sox (24-27), 4-2 | Fenway Park (3-1) | 30-20 | |
| » Starters: Bruce Howard vs Earl Wilson | Second | 2½ out |
| Thursday, June 10 |
| » Defeated Red Sox (24-28), 4-2 | Fenway Park (4-1) | 31-20 | |
| » Starters: Gary Peters vs Dave Morehead | Second | 1½ out |
| Friday, June 11 |
| » Defeated Senators (24-32), 5-2 | Robert F. Kennedy Stadium (3-0) | 32-20 | Won 2 |
| » Starters: Juan Pizarro vs Phil Ortega | Second | 1½ out |
| » Defeated Senators (24-33), 5-4 | Robert F. Kennedy Stadium (4-0) | 33-20 | Won 3 |
| » Starters: John Buzhardt vs Mike McCormick | Second | 1½ out |
| Saturday, June 12 |
| » Lost to Senators (25-33), 7-1 | Robert F. Kennedy Stadium (4-1) | 33-21 | |
| » Starters: Joe Horlen vs Bennie Daniels | Second | 1½ out |
| Sunday, June 13 |
| » Defeated Senators (25-34), 2-1 | Robert F. Kennedy Stadium (5-1) | 34-21 | |
| » Starters: Bruce Howard vs Pete Richert | Second | ½ out |
| Tuesday, June 15 |
| » Lost to Twins (35-20), 4-0 | Comiskey Park I (15-9) | 34-22 | |
| » Starters: Mudcat Grant vs Gary Peters | Second | 1½ out |
| Wednesday, June 16 |
| » Defeated Twins (35-21), 3-1 | Comiskey Park I (16-9) | 35-22 | |
| » Starters: Camilo Pascual vs John Buzhardt | Second | ½ out |
| Thursday, June 17 |
| » Lost to Twins (36-21), 3-1 | Comiskey Park I (16-10) | 35-23 | |
| » Starters: Jim Kaat vs Joe Horlen | Second | 1½ out |
| Friday, June 18 |
| » Defeated Red Sox (24-35), 4-3 | Comiskey Park I (17-10) | 36-23 | |
| » Starters: Jim Lonborg vs Juan Pizarro | Second | ½ out |
| Saturday, June 19 |
| » Lost to Red Sox (25-35), 2-1 | Comiskey Park I (17-11) | 36-24 | |
| » Starters: Bill Monbouquette vs Bruce Howard | Second | ½ out |
| Sunday, June 20 |
| » Defeated Red Sox (25-36), 4-3 | Comiskey Park I (18-11) | 37-24 | |
| » Starters: Dennis Bennett vs Gary Peters | Second | 1 out |
| Wednesday, June 23 |
| » Lost to Senators (27-39), 5-1 | Comiskey Park I (18-12) | 37-25 | |
| » Starters: Pete Richert vs John Buzhardt | Second | 1 out |
| » Defeated Senators (27-40), 5-0 | Comiskey Park I (19-12) | 38-25 | |
| » Starters: Bennie Daniels vs Juan Pizarro | Second | 1 out |
| Friday, June 25 |
| » Defeated Orioles (39-28), 6-0 | Comiskey Park I (20-12) | 39-25 | Won 2 |
| » Starters: Wally Bunker vs Joe Horlen | Second | ½ out |
| Saturday, June 26 |
| » Lost to Orioles (40-28), 2-0 | Comiskey Park I (20-13) | 39-26 | |
| » Starters: Dave McNally vs Gary Peters | Second | ½ out |
| Sunday, June 27 |
| » Defeated Orioles (40-29), 6-2 | Comiskey Park I (21-13) | 40-26 | |
| » Starters: John Miller vs Tommy John | Second | ½ out |
| » Defeated Orioles (40-30), 4-0 | Comiskey Park I (22-13) | 41-26 | Won 2 |
| » Starters: Steve Barber vs Bruce Howard | Second | ½ out |
| Monday, June 28 |
| » Defeated Twins (42-27), 17-4 | Metropolitan Stadium (2-3) | 42-26 | Won 3 |
| » Starters: John Buzhardt vs Dave Boswell | First | -- |
| Tuesday, June 29 |
| » Lost to Twins (43-27), 7-6 | Metropolitan Stadium (2-4) | 42-27 | |
| » Starters: Joe Horlen vs Jim Kaat | Third | 1 out |
| Wednesday, June 30 |
| » Lost to Athletics (21-45), 2-1 | Municipal Stadium (2-2) | 42-28 | Lost 2 |
| » Starters: Gary Peters vs Fred Talbot | Third | 1½ out |
| » Lost to Athletics (22-45), 4-3 | Municipal Stadium (2-3) | 42-29 | Lost 3 |
| » Starters: Bruce Howard vs Rollie Sheldon | Third | 1½ out |
| Friday, July 2 |
| » Lost to Angels (34-41), 5-4 | Dodger Stadium (1-3) | 42-30 | Lost 4 |
| » Starters: Joe Horlen vs Dean Chance | Third | 3 out |
| Saturday, July 3 |
| » Lost to Angels (35-41), 5-1 | Dodger Stadium (1-4) | 42-31 | Lost 5 |
| » Starters: John Buzhardt vs Marcelino Lopez | Second | 3 out |
| Sunday, July 4 |
| » Defeated Angels (35-42), 1-0 | Dodger Stadium (2-4) | 43-31 | |
| » Starters: Tommy John vs George Brunet | Second | 3 out |
| Monday, July 5 |
| » Defeated Indians (46-29), 3-1 | Comiskey Park I (23-13) | 44-31 | Won 2 |
| » Starters: Sam McDowell vs Bruce Howard | Third | 3½ out |
| Wednesday, July 7 |
| » Lost to Indians (47-29), 4-2 | Comiskey Park I (23-14) | 44-32 | |
| » Starters: Luis Tiant vs Gary Peters | Fourth | 5½ out |
| » Lost to Indians (48-29), 4-2 | Comiskey Park I (23-15) | 44-33 | Lost 2 |
| » Starters: Lee Stange vs John Buzhardt | Fourth | 5½ out |
| Thursday, July 8 |
| » Defeated Indians (48-30), 3-2 | Comiskey Park I (24-15) | 45-33 | |
| » Starters: Jack Kralick vs Tommy John | Fourth | 5 out |
| Friday, July 9 |
| » Lost to Orioles (48-34), 1-0 | Memorial Stadium (1-2) | 45-34 | |
| » Starters: Bruce Howard vs Milt Pappas | Fourth | 6 out |
| Saturday, July 10 |
| » Defeated Orioles (48-35), 6-4 | Memorial Stadium (2-2) | 46-34 | |
| » Starters: Gary Peters vs Robin Roberts | Fourth | 6 out |
| » Lost to Orioles (49-35), 5-3 | Memorial Stadium (2-3) | 46-35 | |
| » Starters: Joe Horlen vs Dave McNally | Fourth | 6 out |
| Wednesday, July 14 |
| » Defeated Indians (48-35), 12-10 | Cleveland Stadium (2-1) | 47-35 | |
| » Starters: Gary Peters vs Ralph Terry | Fourth | 6 out |
| Thursday, July 15 |
| » Defeated Angels (41-45), 5-2 | Comiskey Park I (25-15) | 48-35 | Won 2 |
| » Starters: Marcelino Lopez vs Joe Horlen | Third | 5½ out |
| Friday, July 16 |
| » Defeated Angels (41-46), 4-3 | Comiskey Park I (26-15) | 49-35 | Won 3 |
| » Starters: George Brunet vs Bruce Howard | Third | 4½ out |
| Saturday, July 17 |
| » Defeated Angels (41-47), 5-2 | Comiskey Park I (27-15) | 50-35 | Won 4 |
| » Starters: Rudy May vs Tommy John | Third | 3½ out |
| Sunday, July 18 |
| » Defeated Athletics (26-56), 3-2 | Comiskey Park I (28-15) | 51-35 | Won 5 |
| » Starters: Catfish Hunter vs John Buzhardt | Second | 3½ out |
| » Lost to Athletics (27-56), 7-5 | Comiskey Park I (28-16) | 51-36 | |
| » Starters: Fred Talbot vs Gary Peters | Second | 3½ out |
| Monday, July 19 |
| » Lost to Athletics (28-56), 6-3 | Comiskey Park I (28-17) | 51-37 | Lost 2 |
| » Starters: Rollie Sheldon vs Joe Horlen | Third | 4½ out |
| Wednesday, July 21 |
| » Lost to Yankees (46-48), 7-6 | Yankee Stadium (1-4) | 51-38 | Lost 3 |
| » Starters: Tommy John vs Al Downing | Third | 5½ out |
| Thursday, July 22 |
| » Lost to Yankees (47-48), 3-1 | Yankee Stadium (1-5) | 51-39 | Lost 4 |
| » Starters: Gary Peters vs Whitey Ford | Fourth | 6½ out |
| Friday, July 23 |
| » Lost to Tigers (51-39), 6-5 | Tiger Stadium (3-1) | 51-40 | Lost 5 |
| » Starters: John Buzhardt vs Hank Aguirre | Fifth | 6½ out |
| Saturday, July 24 |
| » Lost to Tigers (52-39), 7-4 | Tiger Stadium (3-2) | 51-41 | Lost 6 |
| » Starters: Joe Horlen vs Dave Wickersham | Fifth | 6½ out |
| Sunday, July 25 |
| » Defeated Tigers (52-40), 10-6 | Tiger Stadium (4-2) | 52-41 | |
| » Starters: Tommy John vs Mickey Lolich | Fifth | 7 out |
| » Lost to Tigers (53-40), 13-2 | Tiger Stadium (4-3) | 52-42 | |
| » Starters: Bruce Howard vs Denny McLain | Fifth | 7 out |
| Tuesday, July 27 |
| » Lost to Indians (56-40), 7-3 | Cleveland Stadium (2-2) | 52-43 | Lost 2 |
| » Starters: John Buzhardt vs Ralph Terry | Fifth | 8 out |
| Wednesday, July 28 |
| » Lost to Indians (57-40), 4-2 | Cleveland Stadium (2-3) | 52-44 | Lost 3 |
| » Starters: Joe Horlen vs Sam McDowell | Fifth | 9 out |
| Thursday, July 29 |
| » Defeated Indians (57-41), 9-4 | Cleveland Stadium (3-3) | 53-44 | |
| » Starters: Tommy John vs Luis Tiant | Fifth | 8½ out |
| Friday, July 30 |
| » Lost to Tigers (56-42), 3-1 | Comiskey Park I (28-18) | 53-45 | |
| » Starters: Mickey Lolich vs Juan Pizarro | Fourth | 9½ out |
| Saturday, July 31 |
| » Defeated Tigers (56-43), 4-3 | Comiskey Park I (29-18) | 54-45 | |
| » Starters: Joe Sparma vs Frank Lary | Fourth | 9½ out |
| Sunday, August 1 |
| » Defeated Tigers (56-44), 1-0 | Comiskey Park I (30-18) | 55-45 | Won 2 |
| » Starters: Hank Aguirre vs Joe Horlen | Fifth | 9 out |
| » Lost to Tigers (57-44), 2-1 | Comiskey Park I (30-19) | 55-46 | |
| » Starters: Dave Wickersham vs Tommy John | Fifth | 9 out |
| Monday, August 2 |
| » Defeated Tigers (57-45), 2-0 | Comiskey Park I (31-19) | 56-46 | |
| » Starters: Denny McLain vs Gary Peters | Fourth | 9 out |
| Tuesday, August 3 |
| » Defeated Yankees (52-56), 3-2 | Comiskey Park I (32-19) | 57-46 | Won 2 |
| » Starters: Mel Stottlemyre vs John Buzhardt | Fifth | 8½ out |
| Wednesday, August 4 |
| » Lost to Yankees (53-56), 4-3 | Comiskey Park I (32-20) | 57-47 | |
| » Starters: Al Downing vs Juan Pizarro | Fifth | 9½ out |
| Future White Sox Matt Merullo is born in Winchester, MA. |
| Thursday, August 5 |
| » Lost to Yankees (54-56), 3-0 | Comiskey Park I (32-21) | 57-48 | Lost 2 |
| » Starters: Whitey Ford vs Tommy John | Fifth | 10½ out |
| Friday, August 6 |
| » Defeated Indians (61-45), 11-5 | Comiskey Park I (33-21) | 58-48 | |
| » Starters: Ralph Terry vs Joe Horlen | Fifth | 10½ out |
| Saturday, August 7 |
| » Defeated Indians (61-46), 4-3 | Comiskey Park I (34-21) | 59-48 | Won 2 |
| » Starters: Luis Tiant vs John Buzhardt | Fourth | 10½ out |
| Sunday, August 8 |
| » Lost to Indians (62-46), 6-4 | Comiskey Park I (34-22) | 59-49 | |
| » Starters: Sonny Siebert vs Gary Peters | Fourth | 11½ out |
| Tuesday, August 10 |
| » Defeated Senators (48-65), 6-0 | Comiskey Park I (35-22) | 60-49 | |
| » Starters: Bennie Daniels vs Tommy John | Fourth | 11½ out |
| Wednesday, August 11 |
| » Lost to Senators (49-65), 5-2 | Comiskey Park I (35-23) | 60-50 | |
| » Starters: Pete Richert vs Joe Horlen | Fifth | 11 out |
| » Defeated Senators (49-66), 7-0 | Comiskey Park I (36-23) | 61-50 | |
| » Starters: Mike McCormick vs Juan Pizarro | Fifth | 11 out |
| Friday, August 13 |
| » Lost to Red Sox (43-70), 3-2 | Fenway Park (4-2) | 61-51 | |
| » Starters: John Buzhardt vs Dennis Bennett | Fourth | 11½ out |
| Saturday, August 14 |
| » Defeated Red Sox (43-71), 5-3 | Fenway Park (5-2) | 62-51 | |
| » Starters: Bruce Howard vs Jim Lonborg | Fifth | 10½ out |
| Sunday, August 15 |
| » Defeated Red Sox (43-72), 7-4 | Fenway Park (6-2) | 63-51 | Won 2 |
| » Starters: Tommy John vs Bill Monbouquette | Fourth | 10 out |
| Monday, August 16 |
| » Defeated Red Sox (43-73), 5-4 | Fenway Park (7-2) | 64-51 | Won 3 |
| » Starters: Joe Horlen vs Earl Wilson | Fourth | 9½ out |
| Tuesday, August 17 |
| » Defeated Senators (52-67), 7-2 | Robert F. Kennedy Stadium (6-1) | 65-51 | Won 4 |
| » Starters: John Buzhardt vs Mike McCormick | Third | 8 out |
| » Defeated Senators (52-68), 5-1 | Robert F. Kennedy Stadium (7-1) | 66-51 | Won 5 |
| » Starters: Juan Pizarro vs Bennie Daniels | Third | 8 out |
| Wednesday, August 18 |
| » Defeated Senators (52-69), 8-2 | Robert F. Kennedy Stadium (8-1) | 67-51 | Won 6 |
| » Starters: Bruce Howard vs Phil Ortega | Third | 7½ out |
| Friday, August 20 |
| » Defeated Athletics (41-77), 3-1 | Municipal Stadium (3-3) | 68-51 | Won 7 |
| » Starters: Gary Peters vs Catfish Hunter | Second | 8 out |
| Saturday, August 21 |
| » Defeated Athletics (41-78), 7-6 | Municipal Stadium (4-3) | 69-51 | Won 8 |
| » Starters: Tommy John vs Rollie Sheldon | Second | 8 out |
| Sunday, August 22 |
| » Defeated Athletics (41-79), 8-3 | Municipal Stadium (5-3) | 70-51 | Won 9 |
| » Starters: Joe Horlen vs Fred Talbot | Second | 6½ out |
| » Defeated Athletics (41-80), 2-1 | Municipal Stadium (6-3) | 71-51 | Won 10 |
| » Starters: John Buzhardt vs John O'Donoghue | Second | 6½ out |
| Monday, August 23 |
| » Lost to Orioles (68-53), 2-1 | Comiskey Park I (36-24) | 71-52 | |
| » Starters: Steve Barber vs Juan Pizarro | Second | 7½ out |
| Tuesday, August 24 |
| » Defeated Orioles (68-54), 6-5 | Comiskey Park I (37-24) | 72-52 | |
| » Starters: Dave McNally vs Bruce Howard | Second | 6½ out |
| Wednesday, August 25 |
| » Lost to Orioles (69-54), 2-1 | Comiskey Park I (37-25) | 72-53 | |
| » Starters: Milt Pappas vs Gary Peters | Second | 7½ out |
| Thursday, August 26 |
| » Lost to Orioles (70-54), 8-1 | Comiskey Park I (37-26) | 72-54 | Lost 2 |
| » Starters: John Miller vs Tommy John | Second | 8½ out |
| Friday, August 27 |
| » Defeated Red Sox (48-80), 3-2 | Comiskey Park I (38-26) | 73-54 | |
| » Starters: Jerry Stephenson vs Joe Horlen | Second | 9 out |
| » Lost to Red Sox (49-80), 6-1 | Comiskey Park I (38-27) | 73-55 | |
| » Starters: Dennis Bennett vs John Buzhardt | Second | 9 out |
| Saturday, August 28 |
| » Defeated Red Sox (49-81), 5-3 | Comiskey Park I (39-27) | 74-55 | |
| » Starters: Jim Lonborg vs Juan Pizarro | Second | 8 out |
| Sunday, August 29 |
| » Defeated Red Sox (49-82), 3-2 | Comiskey Park I (40-27) | 75-55 | Won 2 |
| » Starters: Bill Monbouquette vs Bruce Howard | Second | 6½ out |
| » Defeated Red Sox (49-83), 3-2 | Comiskey Park I (41-27) | 76-55 | Won 3 |
| » Starters: Earl Wilson vs Gary Peters | Second | 6½ out |
| Monday, August 30 |
| Former White Sox Frank Papish dies in Pueblo, CO at the age of 48. |
| Tuesday, August 31 |
| » Lost to Orioles (71-57), 4-0 | Memorial Stadium (2-4) | 76-56 | |
| » Starters: Joe Horlen vs John Miller | Second | 7½ out |
| » Lost to Orioles (72-57), 7-2 | Memorial Stadium (2-5) | 76-57 | Lost 2 |
| » Starters: John Buzhardt vs Steve Barber | Second | 7½ out |
| Thursday, September 2 |
| » Defeated Orioles (72-58), 5-3 | Memorial Stadium (3-5) | 77-57 | |
| » Starters: Tommy John vs Dave McNally | Second | 6½ out |
| » Defeated Orioles (72-59), 9-3 | Memorial Stadium (4-5) | 78-57 | Won 2 |
| » Starters: Juan Pizarro vs Milt Pappas | Second | 6½ out |
| Friday, September 3 |
| » Lost to Twins (86-51), 6-4 | Metropolitan Stadium (2-5) | 78-58 | |
| » Starters: Bruce Howard vs Jim Kaat | Second | 7½ out |
| Saturday, September 4 |
| » Defeated Twins (86-52), 5-4 | Metropolitan Stadium (3-5) | 79-58 | |
| » Starters: John Buzhardt vs Mudcat Grant | Second | 6½ out |
| » Major-league debuts: Ted Uhlaender (Twins) |
| Sunday, September 5 |
| » Defeated Twins (86-53), 2-0 | Metropolitan Stadium (4-5) | 80-58 | Won 2 |
| » Starters: Joe Horlen vs Jim Perry | Second | 5½ out |
| Monday, September 6 |
| » Defeated Angels (64-76), 2-1 | Comiskey Park I (42-27) | 81-58 | Won 3 |
| » Starters: Marcelino Lopez vs Gary Peters | Second | 4½ out |
| » Defeated Angels (64-77), 4-3 | Comiskey Park I (43-27) | 82-58 | Won 4 |
| » Starters: Jack Sanford vs Tommy John | Second | 4½ out |
| Tuesday, September 7 |
| » Lost to Indians (77-62), 9-5 | Comiskey Park I (43-28) | 82-59 | |
| » Starters: Jack Kralick vs Juan Pizarro | Second | 5 out |
| Wednesday, September 8 |
| » Lost to Twins (88-54), 3-2 | Comiskey Park I (43-29) | 82-60 | Lost 2 |
| » Starters: Mudcat Grant vs John Buzhardt | Second | 6 out |
| Thursday, September 9 |
| » Lost to Twins (89-54), 10-4 | Comiskey Park I (43-30) | 82-61 | Lost 3 |
| » Starters: Jim Kaat vs Joe Horlen | Second | 7 out |
| Friday, September 10 |
| » Lost to Yankees (70-75), 3-1 | Comiskey Park I (43-31) | 82-62 | Lost 4 |
| » Starters: Mel Stottlemyre vs Gary Peters | Third | 8 out |
| Saturday, September 11 |
| » Lost to Yankees (71-75), 3-1 | Comiskey Park I (43-32) | 82-63 | Lost 5 |
| » Starters: Whitey Ford vs Bruce Howard | Second | 9 out |
| Sunday, September 12 |
| » Defeated Yankees (71-76), 4-1 | Comiskey Park I (44-32) | 83-63 | |
| » Starters: Al Downing vs Tommy John | Second | 9 out |
| Tuesday, September 14 |
| » Lost to Angels (68-79), 7-1 | Dodger Stadium (2-5) | 83-64 | |
| » Starters: Juan Pizarro vs Fred Newman | Third | 10 out |
| » Major-league debuts: Jackie Hernandez (Angels) Bill Voss (White Sox) |
| Wednesday, September 15 |
| » Defeated Angels (68-80), 8-1 | Dodger Stadium (3-5) | 84-64 | |
| » Starters: John Buzhardt vs George Brunet | Third | 10½ out |
| » Lost to Angels (69-80), 2-1 | Dodger Stadium (3-6) | 84-65 | |
| » Starters: Joe Horlen vs Marcelino Lopez | Third | 10½ out |
| » Major-league debuts: Duane Josephson (White Sox) |
| Thursday, September 16 |
| » Major-league debuts: Bill Davis (Indians) |
| Friday, September 17 |
| » Defeated Indians (78-68), 5-4 | Cleveland Stadium (4-3) | 85-65 | |
| » Starters: Gary Peters vs Tom Kelley | Second | 9½ out |
| Saturday, September 18 |
| » Defeated Indians (78-69), 8-5 | Cleveland Stadium (5-3) | 86-65 | Won 2 |
| » Starters: Tommy John vs Steve Hargan | Second | 9½ out |
| Sunday, September 19 |
| » Defeated Indians (78-70), 7-5 | Cleveland Stadium (6-3) | 87-65 | Won 3 |
| » Starters: Juan Pizarro vs Sonny Siebert | Second | 9½ out |
| Monday, September 20 |
| » Major-league debuts: Jim McGlothin (Angels) |
| Tuesday, September 21 |
| » Lost to Tigers (84-68), 6-2 | Tiger Stadium (4-4) | 87-66 | |
| » Starters: Joe Horlen vs Denny McLain | Third | 9 out |
| Wednesday, September 22 |
| » Defeated Tigers (84-69), 2-1 | Tiger Stadium (5-4) | 88-66 | |
| » Starters: John Buzhardt vs Mickey Lolich | Third | 8 out |
| Saturday, September 25 |
| » Defeated Yankees (75-81), 3-1 | Yankee Stadium (2-5) | 89-66 | Won 2 |
| » Starters: Tommy John vs Bill Stafford | Third | 8 out |
| » Defeated |
