| Saturday, January 2 |
| Future Twin Greg Swindell is born in Fort Worth, TX. |
| Wednesday, January 20 |
| Future Twin Kevin Maas is born in Castro Valley, CA. |
| Wednesday, February 10 |
| Future Twin Lenny Webster is born in New Orleans, LA. |
| Wednesday, March 17 |
| Future Twin John Smiley is born in Phoenixville, PA. |
| Monday, April 12 |
| » Defeated Yankees (0-1), 5-4 | Metropolitan Stadium (1-0) | 1-0 | |
| » Starters: Jim Bouton vs Jim Kaat | First | -- |
| » Major-league debuts: Cesar Tovar and Sandy Valdespino (Twins) Art Lopez (Yankees) |
| Thursday, April 15 |
| » Lost to Tigers (3-0), 6-4 | Metropolitan Stadium (1-1) | 1-1 | |
| » Starters: Dave Wickersham vs Camilo Pascual | Third | 1½ out |
| Saturday, April 17 |
| » Defeated Indians (1-2), 3-0 | Metropolitan Stadium (2-1) | 2-1 | |
| » Starters: Dick Donovan vs Jim Kaat | Second | ½ out |
| Sunday, April 18 |
| » Defeated Indians (1-3), 6-3 | Metropolitan Stadium (3-1) | 3-1 | Won 2 |
| » Starters: Ralph Terry vs Mudcat Grant | Second | ½ out |
| Tuesday, April 20 |
| » Major-league debuts: Bob Schroder (Giants) |
| Wednesday, April 21 |
| » Defeated Yankees (3-4), 7-2 | Yankee Stadium (1-0) | 4-1 | Won 3 |
| » Starters: Camilo Pascual vs Mel Stottlemyre | First | -- |
| Thursday, April 22 |
| » Defeated Yankees (3-5), 8-2 | Yankee Stadium (2-0) | 5-1 | Won 4 |
| » Starters: Jim Kaat vs Al Downing | First | -- |
| Friday, April 23 |
| » Defeated Tigers (5-3), 8-6 | Tiger Stadium (1-0) | 6-1 | Won 5 |
| » Starters: Mudcat Grant vs Dave Wickersham | First | -- |
| Saturday, April 24 |
| » Lost to Tigers (6-3), 7-4 | Tiger Stadium (1-1) | 6-2 | |
| » Starters: Dick Stigman vs Phil Regan | First | -- |
| » Major-league debuts: John Sevcik (Twins) |
| Tuesday, April 27 |
| » Defeated Indians (4-4), 11-1 | Cleveland Stadium (1-0) | 7-2 | |
| » Starters: Camilo Pascual vs Sam McDowell | First | -- |
| Wednesday, April 28 |
| » Lost to Indians (5-4), 9-3 | Cleveland Stadium (1-1) | 7-3 | |
| » Starters: Jim Kaat vs Jack Kralick | Second | ½ out |
| Friday, April 30 |
| » Defeated White Sox (8-4), 7-0 | Comiskey Park I (1-0) | 8-3 | |
| » Starters: Mudcat Grant vs Gary Peters | First | -- |
| Saturday, May 1 |
| » Lost to White Sox (9-4), 2-1 | Comiskey Park I (1-1) | 8-4 | |
| » Starters: Camilo Pascual vs Joe Horlen | Second | ½ out |
| Sunday, May 2 |
| » Defeated White Sox (9-5), 3-2 | Comiskey Park I (2-1) | 9-4 | |
| » Starters: Jim Kaat vs Tommy John | Second | ½ out |
| » Lost to White Sox (10-5), 5-4 | Comiskey Park I (2-2) | 9-5 | |
| » Starters: Dave Boswell vs Bruce Howard | Second | ½ out |
| Tuesday, May 4 |
| » Defeated Orioles (9-8), 7-3 | Metropolitan Stadium (4-1) | 10-5 | |
| » Starters: Wally Bunker vs Mudcat Grant | Second | ½ out |
| Wednesday, May 5 |
| » Defeated Orioles (9-9), 9-2 | Metropolitan Stadium (5-1) | 11-5 | Won 2 |
| » Starters: Steve Barber vs Camilo Pascual | Second | 1 out |
| Thursday, May 6 |
| » Lost to Orioles (10-9), 5-1 | Metropolitan Stadium (5-2) | 11-6 | |
| » Starters: Robin Roberts vs Jim Kaat | Second | 1½ out |
| Friday, May 7 |
| » Lost to White Sox (14-5), 13-5 | Metropolitan Stadium (5-3) | 11-7 | Lost 2 |
| » Starters: Tommy John vs Dick Stigman | Second | 2½ out |
| Saturday, May 8 |
| » Defeated White Sox (14-6), 4-1 | Metropolitan Stadium (6-3) | 12-7 | |
| » Starters: Gary Peters vs Mudcat Grant | Second | 1½ out |
| Sunday, May 9 |
| » Defeated White Sox (14-7), 6-1 | Metropolitan Stadium (7-3) | 13-7 | Won 2 |
| » Starters: Bruce Howard vs Camilo Pascual | Second | ½ out |
| » Major-league debuts: Greg Bollo (White Sox) |
| Monday, May 10 |
| » Defeated White Sox (14-8), 4-3 | Metropolitan Stadium (8-3) | 14-7 | Won 3 |
| » Starters: Joe Horlen vs Jim Kaat | First | -- |
| Tuesday, May 11 |
| » Defeated Angels (15-10), 3-2 | Metropolitan Stadium (9-3) | 15-7 | Won 4 |
| » Starters: Dean Chance vs Dick Stigman | First | -- |
| Wednesday, May 12 |
| » Defeated Angels (15-11), 4-3 | Metropolitan Stadium (10-3) | 16-7 | Won 5 |
| » Starters: Rudy May vs Mudcat Grant | First | -- |
| Thursday, May 13 |
| » Lost to Angels (16-11), 4-3 | Metropolitan Stadium (10-4) | 16-8 | |
| » Starters: Fred Newman vs Camilo Pascual | Second | ½ out |
| Friday, May 14 |
| » Defeated Athletics (5-20), 5-3 | Municipal Stadium (1-0) | 17-8 | |
| » Starters: Jim Kaat vs John O'Donoghue | Second | ½ out |
| Saturday, May 15 |
| » Defeated Athletics (5-21), 2-0 | Municipal Stadium (2-0) | 18-8 | Won 2 |
| » Starters: Dave Boswell vs Don Buschhorn | Second | ½ out |
| » Major-league debuts: Don Buschhorn (Athletics) |
| Sunday, May 16 |
| » Lost to Athletics (6-21), 7-4 | Municipal Stadium (2-1) | 18-9 | |
| » Starters: Mudcat Grant vs Diego Segui | Second | 2½ out |
| » Lost to Athletics (7-21), 4-2 | Municipal Stadium (2-2) | 18-10 | Lost 2 |
| » Starters: Dick Stigman vs Fred Talbot | Second | 2½ out |
| Monday, May 17 |
| » Lost to Angels (17-15), 5-4 | Dodger Stadium (0-1) | 18-11 | Lost 3 |
| » Starters: Camilo Pascual vs Fred Newman | Second | 3½ out |
| Tuesday, May 18 |
| » Lost to Angels (18-15), 3-1 | Dodger Stadium (0-2) | 18-12 | Lost 4 |
| » Starters: Jim Kaat vs Marcelino Lopez | Second | 4½ out |
| Wednesday, May 19 |
| » Defeated Angels (18-16), 3-1 | Dodger Stadium (1-2) | 19-12 | |
| » Starters: Dave Boswell vs Dean Chance | Second | 3 out |
| » Defeated Angels (18-17), 3-1 | Dodger Stadium (2-2) | 20-12 | Won 2 |
| » Starters: Mudcat Grant vs Rudy May | Second | 3 out |
| Friday, May 21 |
| » Defeated Athletics (8-24), 6-4 | Metropolitan Stadium (11-4) | 21-12 | Won 3 |
| » Starters: Diego Segui vs Camilo Pascual | Second | 2 out |
| Saturday, May 22 |
| » Lost to Athletics (9-24), 6-2 | Metropolitan Stadium (11-5) | 21-13 | |
| » Starters: Fred Talbot vs Jim Kaat | Second | 2 out |
| Tuesday, May 25 |
| » Defeated Red Sox (17-19), 17-5 | Fenway Park (1-0) | 22-13 | |
| » Starters: Mudcat Grant vs Bill Monbouquette | Second | 1 out |
| Wednesday, May 26 |
| » Defeated Red Sox (17-20), 9-7 | Fenway Park (2-0) | 23-13 | Won 2 |
| » Starters: Camilo Pascual vs Earl Wilson | First | -- |
| Thursday, May 27 |
| » Lost to Red Sox (18-20), 2-0 | Fenway Park (2-1) | 23-14 | |
| » Starters: Jim Kaat vs Dave Morehead | Second | ½ out |
| Friday, May 28 |
| » Defeated Senators (18-26), 4-1 | Robert F. Kennedy Stadium (1-0) | 24-14 | |
| » Starters: Dave Boswell vs Phil Ortega | Second | ½ out |
| Saturday, May 29 |
| » Defeated Senators (18-27), 11-8 | Robert F. Kennedy Stadium (2-0) | 25-14 | Won 2 |
| » Starters: Mudcat Grant vs Bennie Daniels | Second | ½ out |
| » Major-league debuts: Barry Moore (Senators) |
| Sunday, May 30 |
| » Defeated Senators (18-28), 6-0 | Robert F. Kennedy Stadium (3-0) | 26-14 | Won 3 |
| » Starters: Camilo Pascual vs Mike McCormick | First | -- |
| Monday, May 31 |
| » Defeated Orioles (24-21), 6-0 | Memorial Stadium (1-0) | 27-14 | Won 4 |
| » Starters: Jim Kaat vs Robin Roberts | First | -- |
| » Lost to Orioles (25-21), 5-4 | Memorial Stadium (1-1) | 27-15 | |
| » Starters: Dick Stigman vs Jim Palmer | First | -- |
| Wednesday, June 2 |
| » Defeated Red Sox (21-23), 6-3 | Metropolitan Stadium (12-5) | 28-15 | |
| » Starters: Jim Lonborg vs Mudcat Grant | First | -- |
| Thursday, June 3 |
| » Defeated Red Sox (21-24), 4-3 | Metropolitan Stadium (13-5) | 29-15 | Won 2 |
| » Starters: Bill Monbouquette vs Camilo Pascual | First | -- |
| Friday, June 4 |
| » Defeated Senators (22-29), 9-5 | Metropolitan Stadium (14-5) | 30-15 | Won 3 |
| » Starters: Howie Koplitz vs Jim Kaat | First | -- |
| Sunday, June 6 |
| » Defeated Senators (22-30), 11-2 | Metropolitan Stadium (15-5) | 31-15 | Won 4 |
| » Starters: Phil Ortega vs Dave Boswell | First | -- |
| Monday, June 7 |
| » Lost to Indians (25-20), 2-1 | Metropolitan Stadium (15-6) | 31-16 | |
| » Starters: Luis Tiant vs Mudcat Grant | First | -- |
| Tuesday, June 8 |
| » Defeated Indians (25-21), 6-2 | Metropolitan Stadium (16-6) | 32-16 | |
| » Starters: Sonny Siebert vs Camilo Pascual | First | -- |
| Wednesday, June 9 |
| » Lost to Indians (26-21), 2-1 | Metropolitan Stadium (16-7) | 32-17 | |
| » Starters: Ralph Terry vs Jim Kaat | First | -- |
| Thursday, June 10 |
| » Lost to Indians (27-21), 4-1 | Metropolitan Stadium (16-8) | 32-18 | Lost 2 |
| » Starters: Sam McDowell vs Dave Boswell | First | -- |
| Friday, June 11 |
| » Defeated Tigers (27-24), 5-4 | Tiger Stadium (2-1) | 33-18 | |
| » Starters: Mudcat Grant vs Joe Sparma | First | -- |
| » Defeated Tigers (27-25), 5-4 | Tiger Stadium (3-1) | 34-18 | Won 2 |
| » Starters: Mel Nelson vs Mickey Lolich | First | -- |
| Saturday, June 12 |
| » Lost to Tigers (28-25), 8-5 | Tiger Stadium (3-2) | 34-19 | |
| » Starters: Camilo Pascual vs Denny McLain | First | -- |
| Sunday, June 13 |
| » Lost to Tigers (29-25), 5-4 | Tiger Stadium (3-3) | 34-20 | Lost 2 |
| » Starters: Jim Kaat vs Hank Aguirre | First | -- |
| Tuesday, June 15 |
| » Defeated White Sox (34-22), 4-0 | Comiskey Park I (3-2) | 35-20 | |
| » Starters: Mudcat Grant vs Gary Peters | First | -- |
| Wednesday, June 16 |
| » Lost to White Sox (35-22), 3-1 | Comiskey Park I (3-3) | 35-21 | |
| » Starters: Camilo Pascual vs John Buzhardt | First | -- |
| Thursday, June 17 |
| » Defeated White Sox (35-23), 3-1 | Comiskey Park I (4-3) | 36-21 | |
| » Starters: Jim Kaat vs Joe Horlen | First | -- |
| Friday, June 18 |
| » Lost to Yankees (27-33), 10-2 | Yankee Stadium (2-1) | 36-22 | |
| » Starters: Mel Nelson vs Bill Stafford | First | -- |
| Saturday, June 19 |
| » Lost to Yankees (28-33), 5-3 | Yankee Stadium (2-2) | 36-23 | Lost 2 |
| » Starters: Mudcat Grant vs Whitey Ford | First | -- |
| Sunday, June 20 |
| » Defeated Yankees (28-34), 6-4 | Yankee Stadium (3-2) | 37-23 | |
| » Starters: Camilo Pascual vs Mel Stottlemyre | First | -- |
| » Defeated Yankees (28-35), 7-4 | Yankee Stadium (4-2) | 38-23 | Won 2 |
| » Starters: Dave Boswell vs Al Downing | First | -- |
| Tuesday, June 22 |
| » Lost to Indians (37-24), 5-4 | Cleveland Stadium (1-2) | 38-24 | |
| » Starters: Jim Kaat vs Luis Tiant | First | -- |
| Wednesday, June 23 |
| » Defeated Indians (37-25), 6-3 | Cleveland Stadium (2-2) | 39-24 | |
| » Starters: Mudcat Grant vs Sonny Siebert | First | -- |
| Thursday, June 24 |
| » Lost to Indians (38-25), 3-1 | Cleveland Stadium (2-3) | 39-25 | |
| » Starters: Camilo Pascual vs Ralph Terry | First | -- |
| Friday, June 25 |
| » Defeated Tigers (37-28), 4-3 | Metropolitan Stadium (17-8) | 40-25 | |
| » Starters: Dave Wickersham vs Dave Boswell | First | -- |
| Saturday, June 26 |
| » Lost to Tigers (38-28), 5-2 | Metropolitan Stadium (17-9) | 40-26 | |
| » Starters: Mickey Lolich vs Bill Pleis | First | -- |
| Sunday, June 27 |
| » Defeated Tigers (38-29), 6-4 | Metropolitan Stadium (18-9) | 41-26 | |
| » Starters: Joe Sparma vs Mudcat Grant | First | -- |
| » Defeated Tigers (38-30), 6-5 | Metropolitan Stadium (19-9) | 42-26 | Won 2 |
| » Starters: Hank Aguirre vs Mel Nelson | First | -- |
| Monday, June 28 |
| » Lost to White Sox (42-26), 17-4 | Metropolitan Stadium (19-10) | 42-27 | |
| » Starters: John Buzhardt vs Dave Boswell | Second | ½ out |
| Tuesday, June 29 |
| » Defeated White Sox (42-27), 7-6 | Metropolitan Stadium (20-10) | 43-27 | |
| » Starters: Joe Horlen vs Jim Kaat | Second | ½ out |
| Wednesday, June 30 |
| » Lost to Angels (33-41), 5-0 | Dodger Stadium (2-3) | 43-28 | |
| » Starters: Bill Pleis vs Fred Newman | Second | ½ out |
| Friday, July 2 |
| » Defeated Athletics (22-46), 3-1 | Municipal Stadium (3-2) | 44-28 | |
| » Starters: Mudcat Grant vs John O'Donoghue | Second | 1 out |
| Saturday, July 3 |
| » Defeated Athletics (22-47), 3-2 | Municipal Stadium (4-2) | 45-28 | Won 2 |
| » Starters: Jim Kaat vs Diego Segui | First | -- |
| Sunday, July 4 |
| » Defeated Athletics (22-48), 5-2 | Municipal Stadium (5-2) | 46-28 | Won 3 |
| » Starters: Camilo Pascual vs Fred Talbot | First | -- |
| Monday, July 5 |
| » Defeated Red Sox (30-46), 6-2 | Metropolitan Stadium (21-10) | 47-28 | Won 4 |
| » Starters: Earl Wilson vs Dave Boswell | First | -- |
| » Defeated Red Sox (30-47), 2-0 | Metropolitan Stadium (22-10) | 48-28 | Won 5 |
| » Starters: Dave Morehead vs Jim Perry | First | -- |
| Tuesday, July 6 |
| » Defeated Red Sox (30-48), 9-0 | Metropolitan Stadium (23-10) | 49-28 | Won 6 |
| » Starters: Jerry Stephenson vs Mudcat Grant | First | -- |
| Wednesday, July 7 |
| » Defeated Red Sox (30-49), 5-2 | Metropolitan Stadium (24-10) | 50-28 | Won 7 |
| » Starters: Jim Lonborg vs Jim Kaat | First | -- |
| Friday, July 9 |
| » Defeated Yankees (40-44), 8-3 | Metropolitan Stadium (25-10) | 51-28 | Won 8 |
| » Starters: Jim Bouton vs Dave Boswell | First | -- |
| » Major-league debuts: Jim Brenneman (Yankees) |
| Saturday, July 10 |
| » Defeated Yankees (40-45), 4-1 | Metropolitan Stadium (26-10) | 52-28 | Won 9 |
| » Starters: Whitey Ford vs Jim Perry | First | -- |
| » Lost to Yankees (41-45), 8-6 | Metropolitan Stadium (26-11) | 52-29 | |
| » Starters: Mel Stottlemyre vs Mudcat Grant | First | -- |
| Sunday, July 11 |
| » Defeated Yankees (41-46), 6-5 | Metropolitan Stadium (27-11) | 53-29 | |
| » Starters: Al Downing vs Jim Kaat | First | -- |
| Thursday, July 15 |
| » Defeated Athletics (23-55), 11-3 | Metropolitan Stadium (28-11) | 54-29 | Won 2 |
| » Starters: Fred Talbot vs Jim Kaat | First | -- |
| » Lost to Athletics (24-55), 3-2 | Metropolitan Stadium (28-12) | 54-30 | |
| » Starters: Rollie Sheldon vs Jim Perry | First | -- |
| Friday, July 16 |
| » Lost to Athletics (25-55), 10-2 | Metropolitan Stadium (28-13) | 54-31 | Lost 2 |
| » Starters: Diego Segui vs Mudcat Grant | First | -- |
| Saturday, July 17 |
| » Lost to Athletics (26-55), 5-4 | Metropolitan Stadium (28-14) | 54-32 | Lost 3 |
| » Starters: John O'Donoghue vs Dick Stigman | First | -- |
| Sunday, July 18 |
| » Lost to Angels (42-47), 5-3 | Metropolitan Stadium (28-15) | 54-33 | Lost 4 |
| » Starters: Fred Newman vs Jim Kaat | First | -- |
| » Defeated Angels (42-48), 5-4 | Metropolitan Stadium (29-15) | 55-33 | |
| » Starters: Ken McBride vs Mudcat Grant | First | -- |
| » Major-league debuts: Frank Quilici (Twins) |
| Monday, July 19 |
| » Defeated Angels (42-49), 5-2 | Metropolitan Stadium (30-15) | 56-33 | Won 2 |
| » Starters: Dean Chance vs Jim Perry | First | -- |
| Tuesday, July 20 |
| » Lost to Angels (43-49), 9-1 | Metropolitan Stadium (30-16) | 56-34 | |
| » Starters: Marcelino Lopez vs Camilo Pascual | First | -- |
| Wednesday, July 21 |
| » Defeated Red Sox (33-56), 8-6 | Fenway Park (3-1) | 57-34 | |
| » Starters: Jim Kaat vs Earl Wilson | First | -- |
| » Defeated Red Sox (33-57), 11-8 | Fenway Park (4-1) | 58-34 | Won 2 |
| » Starters: Dick Stigman vs Bob Heffner | First | -- |
| Thursday, July 22 |
| » Defeated Red Sox (33-58), 11-5 | Fenway Park (5-1) | 59-34 | Won 3 |
| » Starters: Mudcat Grant vs Dave Morehead | First | -- |
| Friday, July 23 |
| » Lost to Orioles (55-38), 3-2 | Memorial Stadium (1-2) | 59-35 | |
| » Starters: Jim Perry vs Steve Barber | First | -- |
| Saturday, July 24 |
| » Lost to Orioles (56-38), 3-1 | Memorial Stadium (1-3) | 59-36 | Lost 2 |
| » Starters: Camilo Pascual vs Dave McNally | First | -- |
| Sunday, July 25 |
| » Defeated Orioles (56-39), 8-5 | Memorial Stadium (2-3) | 60-36 | |
| » Starters: Jim Kaat vs John Miller | First | -- |
| Monday, July 26 |
| » Defeated Orioles (56-40), 8-2 | Memorial Stadium (3-3) | 61-36 | Won 2 |
| » Starters: Mudcat Grant vs Milt Pappas | First | -- |
| Tuesday, July 27 |
| » Lost to Senators (43-56), 10-7 | Robert F. Kennedy Stadium (3-1) | 61-37 | |
| » Starters: Jim Perry vs Pete Richert | First | -- |
| » Defeated Senators (43-57), 9-5 | Robert F. Kennedy Stadium (4-1) | 62-37 | |
| » Starters: Jim Kaat vs Bennie Daniels | First | -- |
| Wednesday, July 28 |
| » Defeated Senators (43-58), 8-1 | Robert F. Kennedy Stadium (5-1) | 63-37 | Won 2 |
| » Starters: Camilo Pascual vs Phil Ortega | First | -- |
| Friday, July 30 |
| » Defeated Orioles (58-41), 3-2 | Metropolitan Stadium (31-16) | 64-37 | Won 3 |
| » Starters: Dave McNally vs Mudcat Grant | First | -- |
| Saturday, July 31 |
| » Defeated Orioles (58-42), 2-1 | Metropolitan Stadium (32-16) | 65-37 | Won 4 |
| » Starters: John Miller vs Jim Perry | First | -- |
| Sunday, August 1 |
| » Lost to Orioles (59-42), 7-6 | Metropolitan Stadium (32-17) | 65-38 | |
| » Starters: Milt Pappas vs Jim Kaat | First | -- |
| Monday, August 2 |
| » Defeated Orioles (59-43), 6-5 | Metropolitan Stadium (33-17) | 66-38 | |
| » Starters: Steve Barber vs Jim Merritt | First | -- |
| » Major-league debuts: Jim Merritt (Twins) |
| Tuesday, August 3 |
| » Defeated Senators (45-61), 4-3 | Metropolitan Stadium (34-17) | 67-38 | Won 2 |
| » Starters: Bennie Daniels vs Mudcat Grant | First | -- |
| » Lost to Senators (46-61), 4-2 | Metropolitan Stadium (34-18) | 67-39 | |
| » Starters: Mike McCormick vs Dwight Siebler | First | -- |
| Wednesday, August 4 |
| » Defeated Senators (46-62), 4-3 | Metropolitan Stadium (35-18) | 68-39 | |
| » Starters: Buster Narum vs Jim Perry | First | -- |
| Future Twin Matt Merullo is born in Winchester, MA. |
| Thursday, August 5 |
| » Defeated Senators (46-63), 8-5 | Metropolitan Stadium (36-18) | 69-39 | Won 2 |
| » Starters: Pete Richert vs Jim Kaat | First | -- |
| Friday, August 6 |
| » Defeated Red Sox (40-66), 9-3 | Metropolitan Stadium (37-18) | 70-39 | Won 3 |
| » Starters: Bill Monbouquette vs Jim Merritt | First | -- |
| Saturday, August 7 |
| » Defeated Red Sox (40-67), 9-4 | Metropolitan Stadium (38-18) | 71-39 | Won 4 |
| » Starters: Earl Wilson vs Mudcat Grant | First | -- |
| Sunday, August 8 |
| » Defeated Red Sox (40-68), 8-0 | Metropolitan Stadium (39-18) | 72-39 | Won 5 |
| » Starters: Dave Morehead vs Jim Perry | First | -- |
| Tuesday, August 10 |
| » Defeated Yankees (56-58), 7-3 | Yankee Stadium (5-2) | 73-39 | Won 6 |
| » Starters: Jim Kaat vs Whitey Ford | First | -- |
| Wednesday, August 11 |
| » Lost to Yankees (57-58), 5-4 | Yankee Stadium (5-3) | 73-40 | |
| » Starters: Mudcat Grant vs Mel Stottlemyre | First | -- |
| Thursday, August 12 |
| » Defeated Yankees (57-59), 8-2 | Yankee Stadium (6-3) | 74-40 | |
| » Starters: Jim Merritt vs Al Downing | First | -- |
| Friday, August 13 |
| » Lost to Indians (64-49), 3-1 | Cleveland Stadium (2-4) | 74-41 | |
| » Starters: Jim Perry vs Sonny Siebert | First | -- |
| » Major-league debuts: Andy Kosco (Twins) |
| Saturday, August 14 |
| » Lost to Indians (65-49), 3-1 | Cleveland Stadium (2-5) | 74-42 | Lost 2 |
| » Starters: Jim Kaat vs Sam McDowell | First | -- |
| Sunday, August 15 |
| » Defeated Indians (65-50), 4-3 | Cleveland Stadium (3-5) | 75-42 | |
| » Starters: Mudcat Grant vs Luis Tiant | First | -- |
| » Lost to Indians (66-50), 6-4 | Cleveland Stadium (3-6) | 75-43 | |
| » Starters: Dick Stigman vs Steve Hargan | First | -- |
| Tuesday, August 17 |
| » Lost to Tigers (67-50), 7-4 | Tiger Stadium (3-4) | 75-44 | Lost 2 |
| » Starters: Jim Merritt vs Hank Aguirre | First | -- |
| Future Twin Alex Cole is born in Fayetteville, NC. |
| Thursday, August 19 |
| » Defeated Tigers (67-51), 8-3 | Tiger Stadium (4-4) | 76-44 | |
| » Starters: Mudcat Grant vs Dave Wickersham | First | -- |
| » Defeated Tigers (67-52), 2-1 | Tiger Stadium (5-4) | 77-44 | Won 2 |
| » Starters: Jim Kaat vs Mickey Lolich | First | -- |
| Friday, August 20 |
| » Lost to Angels (55-66), 3-1 | Dodger Stadium (2-4) | 77-45 | |
| » Starters: Jim Perry vs Jack Sanford | First | -- |
| » Defeated Angels (55-67), 3-1 | Dodger Stadium (3-4) | 78-45 | |
| » Starters: Dave Boswell vs George Brunet | First | -- |
| Saturday, August 21 |
| » Defeated Angels (55-68), 4-2 | Dodger Stadium (4-4) | 79-45 | Won 2 |
| » Starters: Jim Merritt vs Fred Newman | First | -- |
| Sunday, August 22 |
| » Lost to Angels (56-68), 4-1 | Dodger Stadium (4-5) | 79-46 | |
| » Starters: Jim Kaat vs Dean Chance | First | -- |
| Monday, August 23 |
| » Defeated Yankees (63-62), 4-3 | Metropolitan Stadium (40-18) | 80-46 | |
| » Starters: Whitey Ford vs Mudcat Grant | First | -- |
| Tuesday, August 24 |
| » Lost to Yankees (64-62), 2-1 | Metropolitan Stadium (40-19) | 80-47 | |
| » Starters: Mel Stottlemyre vs Jim Perry | First | -- |
| Wednesday, August 25 |
| » Defeated Yankees (64-63), 5-4 | Metropolitan Stadium (41-19) | 81-47 | |
| » Starters: Al Downing vs Jim Merritt | First | -- |
| Thursday, August 26 |
| » Defeated Yankees (64-64), 9-2 | Metropolitan Stadium (42-19) | 82-47 | Won 2 |
| » Starters: Jack Cullen vs Jim Kaat | First | -- |
| Friday, August 27 |
| » Defeated Indians (70-57), 7-0 | Metropolitan Stadium (43-19) | 83-47 | Won 3 |
| » Starters: Sam McDowell vs Mudcat Grant | First | -- |
| Saturday, August 28 |
| » Lost to Indians (71-57), 6-5 | Metropolitan Stadium (43-20) | 83-48 | |
| » Starters: Luis Tiant vs Jim Perry | First | -- |
| Sunday, August 29 |
| » Lost to Indians (72-57), 3-1 | Metropolitan Stadium (43-21) | 83-49 | Lost 2 |
| » Starters: Steve Hargan vs Jim Merritt | First | -- |
| Monday, August 30 |
| » Defeated Tigers (72-59), 3-2 | Metropolitan Stadium (44-21) | 84-49 | |
| » Starters: Hank Aguirre vs Jim Kaat | First | -- |
| Tuesday, August 31 |
| » Lost to Tigers (73-59), 7-6 | Metropolitan Stadium (44-22) | 84-50 | |
| » Starters: Mickey Lolich vs Mudcat Grant | First | -- |
| Wednesday, September 1 |
| » Defeated Tigers (73-60), 5-2 | Metropolitan Stadium (45-22) | 85-50 | |
| » Starters: Dave Wickersham vs Jim Perry | First | -- |
| Thursday, September 2 |
| » Lost to Tigers (74-60), 5-4 | Metropolitan Stadium (45-23) | 85-51 | |
| » Starters: Joe Sparma vs Jim Merritt | First | -- |
| Friday, September 3 |
| » Defeated White Sox (78-58), 6-4 | Metropolitan Stadium (46-23) | 86-51 | |
| » Starters: Bruce Howard vs Jim Kaat | First | -- |
| Saturday, September 4 |
| » Lost to White Sox (79-58), 5-4 | Metropolitan Stadium (46-24) | 86-52 | |
| » Starters: John Buzhardt vs Mudcat Grant | First | -- |
| » Major-league debuts: Ted Uhlaender (Twins) |
| Sunday, September 5 |
| » Lost to White Sox (80-58), 2-0 | Metropolitan Stadium (46-25) | 86-53 | Lost 2 |
| » Starters: Joe Horlen vs Jim Perry | First | -- |
| Monday, September 6 |
| » Defeated Athletics (50-87), 8-6 | Municipal Stadium (6-2) | 87-53 | |
| » Starters: Camilo Pascual vs John O'Donoghue | First | -- |
| » Lost to Athletics (51-87), 4-3 | Municipal Stadium (6-3) | 87-54 | |
| » Starters: Jim Merritt vs Rollie Sheldon | First | -- |
| Tuesday, September 7 |
| » Major-league debuts: Wayne Redmond (Tigers) |
| Wednesday, September 8 |
| » Defeated White Sox (82-60), 3-2 | Comiskey Park I (5-3) | 88-54 | |
| » Starters: Mudcat Grant vs John Buzhardt | First | -- |
| Thursday, September 9 |
| » Defeated White Sox (82-61), 10-4 | Comiskey Park I (6-3) | 89-54 | Won 2 |
| » Starters: Jim Kaat vs Joe Horlen | First | -- |
| Friday, September 10 |
| » Defeated Red Sox (56-88), 8-5 | Fenway Park (6-1) | 90-54 | Won 3 |
| » Starters: Jim Perry vs Dave Morehead | First | -- |
| Saturday, September 11 |
| » Defeated Red Sox (56-89), 8-4 | Fenway Park (7-1) | 91-54 | Won 4 |
| » Starters: Camilo Pascual vs Jim Lonborg | First | -- |
| Sunday, September 12 |
| » Defeated Red Sox (56-90), 2-0 | Fenway Park (8-1) | 92-54 | Won 5 |
| » Starters: Mudcat Grant vs Earl Wilson | First | -- |
| Tuesday, September 14 |
| » Defeated Athletics (53-91), 4-3 | Metropolitan Stadium (47-25) | 93-54 | Won 6 |
| » Starters: John O'Donoghue vs Jim Kaat | First | -- |
| Wednesday, September 15 |
| » Defeated Athletics (53-92), 7-5 | Metropolitan Stadium (48-25) | 94-54 | Won 7 |
| » Starters: Catfish Hunter vs Jim Perry | First | -- |
| Thursday, September 16 |
| » Major-league debuts: Jim Ray (Astros) |
| Friday, September 17 |
| » Lost to Senators (65-83), 2-1 | Metropolitan Stadium (48-26) | 94-55 | |
| » Starters: Pete Richert vs Camilo Pascual | First | -- |
| Saturday, September 18 |
| » Defeated Senators (65-84), 4-2 | Metropolitan Stadium (49-26) | 95-55 | |
| » Starters: Phil Ortega vs Jim Kaat | First | -- |
| » Major-league debuts: Paul Casanova (Senators) |
| Sunday, September 19 |
| » Defeated Senators (65-85), 8-1 | Metropolitan Stadium (50-26) | 96-55 | Won 2 |
| » Starters: Frank Kreutzer vs Jim Perry | First | -- |
| Monday, September 20 |
| » Lost to Athletics (55-94), 8-2 | Metropolitan Stadium (50-27) | 96-56 | |
| » Starters: Catfish Hunter vs Mudcat Grant | First | -- |
| Tuesday, September 21 |
| » Lost to Orioles (85-64), 6-4 | Metropolitan Stadium (50-28) | 96-57 | Lost 2 |
| » Starters: Milt Pappas vs Camilo Pascual | First | -- |
| Wednesday, September 22 |
| » Lost to Orioles (86-64), 5-2 | Metropolitan Stadium (50-29) | 96-58 | Lost 3 |
| » Starters: Dave McNally vs Jim Kaat | First | -- |
| » Major-league debuts: Pete Cimino (Twins) |
| Future Twin Mark Guthrie is born in Buffalo, NY. |
| Friday, September 24 |
| Future Twin Scott Leius is born in Yonkers, NY. |
| Saturday, September 25 |
| » Defeated Senators (67-87), 5-0 | Robert F. Kennedy Stadium (6-1) | 97-58 | |
| » Starters: Mudcat Grant vs Frank Kreutzer | First | -- |
| » Defeated Senators (67-88), 5-3 | Robert F. Kennedy Stadium (7-1) | 98-58 | Won 2 |
| » Starters: Camilo Pascual vs Jim Duckworth | First | -- |
| Sunday, September 26 |
| » Defeated Senators (67-89), 2-1 | Robert F. Kennedy Stadium (8-1) | 99-58 | Won 3 |
| » Starters: Jim Kaat vs Pete Richert | First | -- |
| Tuesday, September 28 |
| » Lost to Orioles (92-64), 4-2 | Memorial Stadium (3-4) | 99-59 | |
| » Starters: Jim Perry vs Wally Bunker | First | -- |
| Wednesday, September 29 |
| » Defeated Orioles (92-65 |
