| Wednesday, January 20 |
| Former Senator Nick Altrock dies in Washington, DC at the age of 89. |
| Monday, April 12 |
| » Lost to Red Sox (1-0), 7-2 | Robert F. Kennedy Stadium (0-1) | 0-1 | |
| » Starters: Bill Monbouquette vs Phil Ortega | Third | 1 out |
| Wednesday, April 14 |
| » Defeated Red Sox (1-1), 6-4 | Robert F. Kennedy Stadium (1-1) | 1-1 | |
| » Starters: Earl Wilson vs Buster Narum | Third | 1 out |
| Thursday, April 15 |
| » Defeated White Sox (1-2), 3-1 | Comiskey Park I (1-0) | 2-1 | Won 2 |
| » Starters: Bennie Daniels vs John Buzhardt | Second | 1 out |
| Saturday, April 17 |
| » Lost to White Sox (2-2), 2-1 | Comiskey Park I (1-1) | 2-2 | |
| » Starters: Phil Ortega vs Bruce Howard | Third | 1 out |
| Sunday, April 18 |
| » Lost to White Sox (3-2), 5-1 | Comiskey Park I (1-2) | 2-3 | Lost 2 |
| » Starters: Frank Kreutzer vs Gary Peters | Fourth | 1½ out |
| » Defeated White Sox (3-3), 4-1 | Comiskey Park I (2-2) | 3-3 | |
| » Starters: Pete Richert vs Joe Horlen | Fourth | 1½ out |
| Tuesday, April 20 |
| » Lost to Red Sox (4-1), 5-2 | Fenway Park (0-1) | 3-4 | |
| » Starters: Buster Narum vs Dave Morehead | Sixth | 2 out |
| Wednesday, April 21 |
| » Lost to Orioles (2-4), 3-2 | Robert F. Kennedy Stadium (1-2) | 3-5 | Lost 2 |
| » Starters: Dave McNally vs Bennie Daniels | Seventh | 2½ out |
| Thursday, April 22 |
| » Lost to Orioles (3-4), 18-4 | Robert F. Kennedy Stadium (1-3) | 3-6 | Lost 3 |
| » Starters: Wally Bunker vs Phil Ortega | Eighth | 3½ out |
| Friday, April 23 |
| » Lost to White Sox (6-3), 5-3 | Robert F. Kennedy Stadium (1-4) | 3-7 | Lost 4 |
| » Starters: Juan Pizarro vs Pete Richert | Ninth | 4½ out |
| Saturday, April 24 |
| » Lost to White Sox (7-3), 6-2 | Robert F. Kennedy Stadium (1-5) | 3-8 | Lost 5 |
| » Starters: Bruce Howard vs Buster Narum | Ninth | 4½ out |
| Tuesday, April 27 |
| » Defeated Orioles (4-6), 5-2 | Memorial Stadium (1-0) | 4-8 | |
| » Starters: Bennie Daniels vs Dave McNally | Eighth | 4½ out |
| Wednesday, April 28 |
| » Lost to Orioles (5-6), 6-3 | Robert F. Kennedy Stadium (1-6) | 4-9 | |
| » Starters: Robin Roberts vs Pete Richert | Eighth | 5 out |
| Thursday, April 29 |
| » Lost to Orioles (6-6), 5-4 | Memorial Stadium (1-1) | 4-10 | Lost 2 |
| » Starters: Phil Ortega vs Wally Bunker | Seventh | 5½ out |
| Friday, April 30 |
| » Lost to Indians (6-4), 5-2 | Cleveland Stadium (0-1) | 4-11 | Lost 3 |
| » Starters: Buster Narum vs Ralph Terry | Seventh | 6 out |
| Saturday, May 1 |
| » Lost to Indians (7-4), 7-2 | Cleveland Stadium (0-2) | 4-12 | Lost 4 |
| » Starters: Bennie Daniels vs Luis Tiant | Sixth | 6½ out |
| Sunday, May 2 |
| » Defeated Indians (7-5), 3-2 | Cleveland Stadium (1-2) | 5-12 | |
| » Starters: Mike McCormick vs Jack Kralick | Eighth | 5½ out |
| » Defeated Indians (7-6), 4-2 | Cleveland Stadium (2-2) | 6-12 | Won 2 |
| » Starters: Dallas Green vs Sam McDowell | Eighth | 5½ out |
| Monday, May 3 |
| » Lost to Athletics (4-11), 5-3 | Municipal Stadium (0-1) | 6-13 | |
| » Starters: Pete Richert vs Diego Segui | Ninth | 6 out |
| Tuesday, May 4 |
| » Defeated Athletics (4-12), 4-2 | Municipal Stadium (1-1) | 7-13 | |
| » Starters: Phil Ortega vs John O'Donoghue | Ninth | 6 out |
| » Major-league debuts: Rene Lachemann (Athletics) |
| Friday, May 7 |
| » Defeated Yankees (8-11), 4-3 | Robert F. Kennedy Stadium (2-6) | 8-13 | Won 2 |
| » Starters: Mel Stottlemyre vs Mike McCormick | Eighth | 6½ out |
| » Defeated Yankees (8-12), 7-3 | Robert F. Kennedy Stadium (3-6) | 9-13 | Won 3 |
| » Starters: Al Downing vs Dallas Green | Eighth | 6½ out |
| Saturday, May 8 |
| » Lost to Yankees (9-12), 7-3 | Robert F. Kennedy Stadium (3-7) | 9-14 | |
| » Starters: Jim Bouton vs Pete Richert | Ninth | 6½ out |
| Sunday, May 9 |
| » Defeated Yankees (9-13), 5-4 | Robert F. Kennedy Stadium (4-7) | 10-14 | |
| » Starters: Whitey Ford vs Phil Ortega | Seventh | 5½ out |
| Tuesday, May 11 |
| » Lost to Tigers (12-11), 7-6 | Robert F. Kennedy Stadium (4-8) | 10-15 | |
| » Starters: Dave Wickersham vs Frank Kreutzer | Ninth | 6½ out |
| Wednesday, May 12 |
| » Lost to Tigers (13-11), 5-2 | Robert F. Kennedy Stadium (4-9) | 10-16 | Lost 2 |
| » Starters: Joe Sparma vs Mike McCormick | Ninth | 7½ out |
| Thursday, May 13 |
| » Lost to Tigers (14-11), 13-3 | Robert F. Kennedy Stadium (4-10) | 10-17 | Lost 3 |
| » Starters: Hank Aguirre vs Bennie Daniels | Ninth | 8 out |
| Friday, May 14 |
| » Lost to Indians (12-11), 2-1 | Robert F. Kennedy Stadium (4-11) | 10-18 | Lost 4 |
| » Starters: Sam McDowell vs Phil Ortega | Ninth | 9 out |
| Saturday, May 15 |
| » Defeated Indians (12-12), 9-7 | Robert F. Kennedy Stadium (5-11) | 11-18 | |
| » Starters: Sonny Siebert vs Buster Narum | Ninth | 9 out |
| Sunday, May 16 |
| » Defeated Indians (12-13), 8-7 | Robert F. Kennedy Stadium (6-11) | 12-18 | Won 2 |
| » Starters: Ralph Terry vs Mike McCormick | Eighth | 10 out |
| » Lost to Indians (13-13), 7-3 | Robert F. Kennedy Stadium (6-12) | 12-19 | |
| » Starters: Luis Tiant vs Frank Kreutzer | Eighth | 10 out |
| Tuesday, May 18 |
| » Defeated Tigers (16-14), 15-9 | Tiger Stadium (1-0) | 13-19 | |
| » Starters: Phil Ortega vs Hank Aguirre | Ninth | 10½ out |
| Wednesday, May 19 |
| » Lost to Tigers (17-14), 4-0 | Tiger Stadium (1-1) | 13-20 | |
| » Starters: Bennie Daniels vs Denny McLain | Ninth | 10½ out |
| Former Senator Eric Erickson dies in Jamestown, NY at the age of 71. |
| Thursday, May 20 |
| » Lost to Tigers (18-14), 9-8 | Tiger Stadium (1-2) | 13-21 | Lost 2 |
| » Starters: Frank Kreutzer vs Mickey Lolich | Ninth | 11 out |
| Friday, May 21 |
| » Defeated Yankees (14-20), 5-4 | Yankee Stadium (1-0) | 14-21 | |
| » Starters: Mike McCormick vs Jim Bouton | Ninth | 10 out |
| Saturday, May 22 |
| » Lost to Yankees (15-20), 6-0 | Yankee Stadium (1-1) | 14-22 | |
| » Starters: Pete Richert vs Whitey Ford | Ninth | 10 out |
| Sunday, May 23 |
| » Defeated Yankees (15-21), 7-3 | Yankee Stadium (2-1) | 15-22 | |
| » Starters: Phil Ortega vs Bill Stafford | Ninth | 10½ out |
| » Lost to Yankees (16-21), 3-2 | Yankee Stadium (2-2) | 15-23 | |
| » Starters: Buster Narum vs Al Downing | Ninth | 10½ out |
| Monday, May 24 |
| » Lost to Orioles (21-17), 2-1 | Robert F. Kennedy Stadium (6-13) | 15-24 | Lost 2 |
| » Starters: Jim Palmer vs Bennie Daniels | Ninth | 10½ out |
| Tuesday, May 25 |
| » Defeated Angels (20-19), 7-3 | Robert F. Kennedy Stadium (7-13) | 16-24 | |
| » Starters: Fred Newman vs Mike McCormick | Ninth | 9 out |
| » Defeated Angels (20-20), 6-5 | Robert F. Kennedy Stadium (8-13) | 17-24 | Won 2 |
| » Starters: Rudy May vs Howie Koplitz | Ninth | 9 out |
| Wednesday, May 26 |
| » Lost to Angels (21-20), 2-1 | Robert F. Kennedy Stadium (8-14) | 17-25 | |
| » Starters: Marcelino Lopez vs Pete Richert | Ninth | 9 out |
| Thursday, May 27 |
| » Defeated Angels (21-21), 9-6 | Robert F. Kennedy Stadium (9-14) | 18-25 | |
| » Starters: Dean Chance vs Buster Narum | Ninth | 8½ out |
| » Major-league debuts: Tom Egan (Angels) |
| Friday, May 28 |
| » Lost to Twins (24-14), 4-1 | Robert F. Kennedy Stadium (9-15) | 18-26 | |
| » Starters: Dave Boswell vs Phil Ortega | Ninth | 9½ out |
| Saturday, May 29 |
| » Lost to Twins (25-14), 11-8 | Robert F. Kennedy Stadium (9-16) | 18-27 | Lost 2 |
| » Starters: Mudcat Grant vs Bennie Daniels | Ninth | 10½ out |
| » Major-league debuts: Barry Moore (Senators) |
| Former Senator Mike McNally dies in Bethlehem, PA at the age of 73. |
| Sunday, May 30 |
| » Lost to Twins (26-14), 6-0 | Robert F. Kennedy Stadium (9-17) | 18-28 | Lost 3 |
| » Starters: Camilo Pascual vs Mike McCormick | Ninth | 11 out |
| Monday, May 31 |
| » Defeated Athletics (10-28), 5-2 | Robert F. Kennedy Stadium (10-17) | 19-28 | |
| » Starters: John O'Donoghue vs Howie Koplitz | Ninth | 10 out |
| » Defeated Athletics (10-29), 5-1 | Robert F. Kennedy Stadium (11-17) | 20-28 | Won 2 |
| » Starters: Diego Segui vs Pete Richert | Ninth | 10 out |
| Wednesday, June 2 |
| » Defeated Angels (25-25), 13-0 | Dodger Stadium (1-0) | 21-28 | Won 3 |
| » Starters: Phil Ortega vs Fred Newman | Eighth | 9½ out |
| » Defeated Angels (25-26), 7-1 | Dodger Stadium (2-0) | 22-28 | Won 4 |
| » Starters: Bennie Daniels vs Aubrey Gatewood | Eighth | 9½ out |
| Friday, June 4 |
| » Lost to Twins (30-15), 9-5 | Metropolitan Stadium (0-1) | 22-29 | |
| » Starters: Howie Koplitz vs Jim Kaat | Eighth | 11 out |
| Sunday, June 6 |
| » Lost to Twins (31-15), 11-2 | Metropolitan Stadium (0-2) | 22-30 | Lost 2 |
| » Starters: Phil Ortega vs Dave Boswell | Ninth | 12 out |
| Tuesday, June 8 |
| » Defeated Orioles (27-24), 2-0 | Robert F. Kennedy Stadium (12-17) | 23-30 | |
| » Starters: Steve Barber vs Pete Richert | Ninth | 11½ out |
| Wednesday, June 9 |
| » Defeated Orioles (27-25), 3-2 | Memorial Stadium (2-1) | 24-30 | Won 2 |
| » Starters: Howie Koplitz vs Milt Pappas | Ninth | 10½ out |
| Thursday, June 10 |
| » Lost to Orioles (28-25), 5-1 | Robert F. Kennedy Stadium (12-18) | 24-31 | |
| » Starters: Wally Bunker vs Buster Narum | Eighth | 10½ out |
| Friday, June 11 |
| » Lost to White Sox (32-20), 5-2 | Robert F. Kennedy Stadium (12-19) | 24-32 | Lost 2 |
| » Starters: Juan Pizarro vs Phil Ortega | Ninth | 12½ out |
| » Lost to White Sox (33-20), 5-4 | Robert F. Kennedy Stadium (12-20) | 24-33 | Lost 3 |
| » Starters: John Buzhardt vs Mike McCormick | Ninth | 12½ out |
| Saturday, June 12 |
| » Defeated White Sox (33-21), 7-1 | Robert F. Kennedy Stadium (13-20) | 25-33 | |
| » Starters: Joe Horlen vs Bennie Daniels | Ninth | 11½ out |
| Sunday, June 13 |
| » Lost to White Sox (34-21), 2-1 | Robert F. Kennedy Stadium (13-21) | 25-34 | |
| » Starters: Bruce Howard vs Pete Richert | Ninth | 11½ out |
| Tuesday, June 15 |
| » Lost to Indians (30-24), 8-3 | Cleveland Stadium (2-3) | 25-35 | Lost 2 |
| » Starters: Howie Koplitz vs Sam McDowell | Ninth | 12½ out |
| Wednesday, June 16 |
| » Lost to Indians (31-24), 5-0 | Cleveland Stadium (2-4) | 25-36 | Lost 3 |
| » Starters: Phil Ortega vs Luis Tiant | Ninth | 12½ out |
| Thursday, June 17 |
| » Lost to Indians (32-24), 5-0 | Cleveland Stadium (2-5) | 25-37 | Lost 4 |
| » Starters: Bennie Daniels vs Sonny Siebert | Ninth | 13½ out |
| Friday, June 18 |
| » Defeated Orioles (34-26), 2-0 | Memorial Stadium (3-1) | 26-37 | |
| » Starters: Pete Richert vs Jim Palmer | Eighth | 12½ out |
| Saturday, June 19 |
| » Lost to Orioles (35-26), 3-1 | Memorial Stadium (3-2) | 26-38 | |
| » Starters: Buster Narum vs Milt Pappas | Ninth | 12½ out |
| Sunday, June 20 |
| » Lost to Orioles (36-26), 13-2 | Memorial Stadium (3-3) | 26-39 | Lost 2 |
| » Starters: Howie Koplitz vs Wally Bunker | Ninth | 14 out |
| Wednesday, June 23 |
| » Defeated White Sox (37-25), 5-1 | Comiskey Park I (3-2) | 27-39 | |
| » Starters: Pete Richert vs John Buzhardt | Ninth | 14 out |
| » Lost to White Sox (38-25), 5-0 | Comiskey Park I (3-3) | 27-40 | |
| » Starters: Bennie Daniels vs Juan Pizarro | Ninth | 14 out |
| Friday, June 25 |
| » Lost to Red Sox (27-39), 8-6 | Fenway Park (0-2) | 27-41 | Lost 2 |
| » Starters: Buster Narum vs Dennis Bennett | Eighth | 14½ out |
| Saturday, June 26 |
| » Defeated Red Sox (27-40), 12-7 | Fenway Park (1-2) | 28-41 | |
| » Starters: Howie Koplitz vs Dave Morehead | Seventh | 13½ out |
| Sunday, June 27 |
| » Lost to Red Sox (28-40), 4-1 | Fenway Park (1-3) | 28-42 | |
| » Starters: Bennie Daniels vs Jim Lonborg | Eighth | 15½ out |
| » Lost to Red Sox (29-40), 5-4 | Fenway Park (1-4) | 28-43 | Lost 2 |
| » Starters: Frank Kreutzer vs Earl Wilson | Eighth | 15½ out |
| Monday, June 28 |
| » Lost to Yankees (34-37), 3-0 | Robert F. Kennedy Stadium (13-22) | 28-44 | Lost 3 |
| » Starters: Mel Stottlemyre vs Pete Richert | Eighth | 16½ out |
| » Lost to Yankees (35-37), 4-3 | Robert F. Kennedy Stadium (13-23) | 28-45 | Lost 4 |
| » Starters: Bill Stafford vs Mike McCormick | Eighth | 16½ out |
| Tuesday, June 29 |
| » Defeated Yankees (35-38), 2-1 | Robert F. Kennedy Stadium (14-23) | 29-45 | |
| » Starters: Al Downing vs Buster Narum | Ninth | 16½ out |
| Wednesday, June 30 |
| » Defeated Indians (43-27), 2-1 | Robert F. Kennedy Stadium (15-23) | 30-45 | Won 2 |
| » Starters: Sam McDowell vs Phil Ortega | Ninth | 15½ out |
| Thursday, July 1 |
| » Lost to Indians (44-27), 7-2 | Robert F. Kennedy Stadium (15-24) | 30-46 | |
| » Starters: Sonny Siebert vs Howie Koplitz | Ninth | 16½ out |
| Friday, July 2 |
| » Defeated Tigers (40-32), 6-0 | Robert F. Kennedy Stadium (16-24) | 31-46 | |
| » Starters: Hank Aguirre vs Frank Kreutzer | Eighth | 16½ out |
| Saturday, July 3 |
| » Lost to Tigers (41-32), 1-0 | Robert F. Kennedy Stadium (16-25) | 31-47 | |
| » Starters: Denny McLain vs Pete Richert | Seventh | 16½ out |
| Sunday, July 4 |
| » Defeated Tigers (41-33), 6-3 | Robert F. Kennedy Stadium (17-25) | 32-47 | |
| » Starters: Dave Wickersham vs Buster Narum | Seventh | 16½ out |
| Monday, July 5 |
| » Lost to Angels (36-42), 5-2 | Dodger Stadium (2-1) | 32-48 | |
| » Starters: Mike McCormick vs Rudy May | Eighth | 17½ out |
| » Defeated Angels (36-43), 4-3 | Dodger Stadium (3-1) | 33-48 | |
| » Starters: Phil Ortega vs Fred Newman | Eighth | 17½ out |
| Tuesday, July 6 |
| » Lost to Angels (37-43), 6-2 | Dodger Stadium (3-2) | 33-49 | |
| » Starters: Bennie Daniels vs Dean Chance | Eighth | 18½ out |
| Wednesday, July 7 |
| » Defeated Angels (37-44), 3-1 | Dodger Stadium (4-2) | 34-49 | |
| » Starters: Frank Kreutzer vs Ken McBride | Eighth | 18½ out |
| Friday, July 9 |
| » Defeated Red Sox (30-50), 2-1 | Robert F. Kennedy Stadium (18-25) | 35-49 | Won 2 |
| » Starters: Bill Monbouquette vs Pete Richert | Eighth | 19 out |
| » Lost to Red Sox (31-50), 10-1 | Robert F. Kennedy Stadium (18-26) | 35-50 | |
| » Starters: Earl Wilson vs Buster Narum | Eighth | 19 out |
| Saturday, July 10 |
| » Defeated Red Sox (31-51), 5-3 | Robert F. Kennedy Stadium (19-26) | 36-50 | |
| » Starters: Dave Morehead vs Phil Ortega | Eighth | 18½ out |
| Thursday, July 15 |
| » Lost to Yankees (42-46), 2-1 | Yankee Stadium (2-3) | 36-51 | |
| » Starters: Phil Ortega vs Mel Stottlemyre | Eighth | 19½ out |
| Friday, July 16 |
| » Lost to Yankees (43-46), 9-5 | Yankee Stadium (2-4) | 36-52 | Lost 2 |
| » Starters: Pete Richert vs Al Downing | Eighth | 19½ out |
| Saturday, July 17 |
| » Lost to Yankees (44-46), 5-4 | Yankee Stadium (2-5) | 36-53 | Lost 3 |
| » Starters: Buster Narum vs Whitey Ford | Eighth | 19½ out |
| Sunday, July 18 |
| » Defeated Yankees (44-47), 3-0 | Yankee Stadium (3-5) | 37-53 | |
| » Starters: Mike McCormick vs Pete Mikkelsen | Sixth | 19 out |
| Monday, July 19 |
| » Defeated Tigers (47-39), 8-0 | Tiger Stadium (2-2) | 38-53 | Won 2 |
| » Starters: Phil Ortega vs Mickey Lolich | Seventh | 19 out |
| Tuesday, July 20 |
| » Lost to Tigers (48-39), 2-0 | Tiger Stadium (2-3) | 38-54 | |
| » Starters: Howie Koplitz vs Dave Wickersham | Seventh | 19 out |
| Wednesday, July 21 |
| » Lost to Angels (44-49), 2-0 | Robert F. Kennedy Stadium (19-27) | 38-55 | Lost 2 |
| » Starters: George Brunet vs Buster Narum | Eighth | 20½ out |
| Thursday, July 22 |
| » Defeated Angels (44-50), 5-1 | Robert F. Kennedy Stadium (20-27) | 39-55 | |
| » Starters: Rudy May vs Pete Richert | Eighth | 20½ out |
| Friday, July 23 |
| » Defeated Athletics (29-59), 5-3 | Robert F. Kennedy Stadium (21-27) | 40-55 | Won 2 |
| » Starters: Catfish Hunter vs Mike McCormick | Eighth | 19½ out |
| Saturday, July 24 |
| » Defeated Athletics (29-60), 9-2 | Robert F. Kennedy Stadium (22-27) | 41-55 | Won 3 |
| » Starters: Rollie Sheldon vs Phil Ortega | Eighth | 18½ out |
| Sunday, July 25 |
| » Defeated Athletics (29-61), 4-3 | Robert F. Kennedy Stadium (23-27) | 42-55 | Won 4 |
| » Starters: Diego Segui vs Howie Koplitz | Eighth | 19 out |
| » Lost to Athletics (30-61), 5-3 | Robert F. Kennedy Stadium (23-28) | 42-56 | |
| » Starters: John O'Donoghue vs Buster Narum | Eighth | 19 out |
| Tuesday, July 27 |
| » Defeated Twins (61-37), 10-7 | Robert F. Kennedy Stadium (24-28) | 43-56 | |
| » Starters: Jim Perry vs Pete Richert | Eighth | 19½ out |
| » Lost to Twins (62-37), 9-5 | Robert F. Kennedy Stadium (24-29) | 43-57 | |
| » Starters: Jim Kaat vs Bennie Daniels | Eighth | 19½ out |
| Wednesday, July 28 |
| » Lost to Twins (63-37), 8-1 | Robert F. Kennedy Stadium (24-30) | 43-58 | Lost 2 |
| » Starters: Camilo Pascual vs Phil Ortega | Eighth | 20½ out |
| Friday, July 30 |
| » Defeated Athletics (32-64), 3-1 | Municipal Stadium (2-1) | 44-58 | |
| » Starters: Mike McCormick vs John O'Donoghue | Seventh | 20½ out |
| Saturday, July 31 |
| » Lost to Athletics (33-64), 5-4 | Municipal Stadium (2-2) | 44-59 | |
| » Starters: Buster Narum vs Fred Talbot | Seventh | 21½ out |
| Sunday, August 1 |
| » Defeated Athletics (33-65), 3-2 | Municipal Stadium (3-2) | 45-59 | |
| » Starters: Pete Richert vs Rollie Sheldon | Eighth | 21 out |
| » Lost to Athletics (34-65), 3-2 | Municipal Stadium (3-3) | 45-60 | |
| » Starters: Phil Ortega vs Catfish Hunter | Eighth | 21 out |
| Monday, August 2 |
| » Major-league debuts: Jim Merritt (Twins) |
| Tuesday, August 3 |
| » Lost to Twins (67-38), 4-3 | Metropolitan Stadium (0-3) | 45-61 | Lost 2 |
| » Starters: Bennie Daniels vs Mudcat Grant | Eighth | 21½ out |
| » Defeated Twins (67-39), 4-2 | Metropolitan Stadium (1-3) | 46-61 | |
| » Starters: Mike McCormick vs Dwight Siebler | Eighth | 21½ out |
| Wednesday, August 4 |
| » Lost to Twins (68-39), 4-3 | Metropolitan Stadium (1-4) | 46-62 | |
| » Starters: Buster Narum vs Jim Perry | Eighth | 22½ out |
| Thursday, August 5 |
| » Lost to Twins (69-39), 8-5 | Metropolitan Stadium (1-5) | 46-63 | Lost 2 |
| » Starters: Pete Richert vs Jim Kaat | Eighth | 23½ out |
| Friday, August 6 |
| » Lost to Angels (49-58), 6-1 | Dodger Stadium (4-3) | 46-64 | Lost 3 |
| » Starters: Phil Ortega vs Marcelino Lopez | Eighth | 24½ out |
| Saturday, August 7 |
| » Defeated Angels (49-59), 2-1 | Dodger Stadium (5-3) | 47-64 | |
| » Starters: Mike McCormick vs George Brunet | Seventh | 24½ out |
| Sunday, August 8 |
| » Defeated Angels (49-60), 6-4 | Dodger Stadium (6-3) | 48-64 | Won 2 |
| » Starters: Buster Narum vs Fred Newman | Seventh | 24½ out |
| Tuesday, August 10 |
| » Lost to White Sox (60-49), 6-0 | Comiskey Park I (3-4) | 48-65 | |
| » Starters: Bennie Daniels vs Tommy John | Seventh | 25½ out |
| Wednesday, August 11 |
| » Defeated White Sox (60-50), 5-2 | Comiskey Park I (4-4) | 49-65 | |
| » Starters: Pete Richert vs Joe Horlen | Eighth | 25 out |
| » Lost to White Sox (61-50), 7-0 | Comiskey Park I (4-5) | 49-66 | |
| » Starters: Mike McCormick vs Juan Pizarro | Eighth | 25 out |
| Friday, August 13 |
| » Defeated Orioles (65-49), 4-2 | Memorial Stadium (4-3) | 50-66 | |
| » Starters: Phil Ortega vs Wally Bunker | Seventh | 24½ out |
| Saturday, August 14 |
| » Defeated Orioles (65-50), 8-5 | Memorial Stadium (5-3) | 51-66 | Won 2 |
| » Starters: Frank Kreutzer vs Milt Pappas | Eighth | 23½ out |
| Sunday, August 15 |
| » Defeated Orioles (65-51), 4-2 | Memorial Stadium (6-3) | 52-66 | Won 3 |
| » Starters: Pete Richert vs John Miller | Seventh | 23 out |
| Tuesday, August 17 |
| » Lost to White Sox (65-51), 7-2 | Robert F. Kennedy Stadium (24-31) | 52-67 | |
| » Starters: John Buzhardt vs Mike McCormick | Sixth | 23½ out |
| » Lost to White Sox (66-51), 5-1 | Robert F. Kennedy Stadium (24-32) | 52-68 | Lost 2 |
| » Starters: Juan Pizarro vs Bennie Daniels | Sixth | 23½ out |
| Wednesday, August 18 |
| » Lost to White Sox (67-51), 8-2 | Robert F. Kennedy Stadium (24-33) | 52-69 | Lost 3 |
| » Starters: Bruce Howard vs Phil Ortega | Seventh | 24 out |
| Friday, August 20 |
| » Defeated Indians (67-53), 3-2 | Robert F. Kennedy Stadium (25-33) | 53-69 | |
| » Starters: Luis Tiant vs Buster Narum | Seventh | 24½ out |
| Saturday, August 21 |
| » Defeated Indians (67-54), 4-2 | Robert F. Kennedy Stadium (26-33) | 54-69 | Won 2 |
| » Starters: Steve Hargan vs Mike McCormick | Eighth | 24½ out |
| Sunday, August 22 |
| » Lost to Indians (68-54), 8-5 | Robert F. Kennedy Stadium (26-34) | 54-70 | |
| » Starters: Sam McDowell vs Phil Ortega | Eighth | 24½ out |
| Tuesday, August 24 |
| » Lost to Red Sox (46-78), 9-4 | Fenway Park (1-5) | 54-71 | Lost 2 |
| » Starters: Buster Narum vs Jim Lonborg | Eighth | 24½ out |
| » Defeated Red Sox (46-79), 8-5 | Fenway Park (2-5) | 55-71 | |
| » Starters: Jim Duckworth vs Bill Monbouquette | Eighth | 24½ out |
| Wednesday, August 25 |
| » Lost to Red Sox (47-79), 8-3 | Fenway Park (2-6) | 55-72 | |
| » Starters: Mike McCormick vs Earl Wilson | Eighth | 25½ out |
| Thursday, August 26 |
| » Lost to Red Sox (48-79), 4-2 | Fenway Park (2-7) | 55-73 | Lost 2 |
| » Starters: Phil Ortega vs Dave Morehead | Eighth | 26½ out |
| Friday, August 27 |
| » Defeated Orioles (70-55), 2-1 | Robert F. Kennedy Stadium (27-34) | 56-73 | |
| » Starters: Steve Barber vs Frank Kreutzer | Eighth | 26½ out |
| Saturday, August 28 |
| » Defeated Orioles (70-56), 5-4 | Robert F. Kennedy Stadium (28-34) | 57-73 | Won 2 |
| » Starters: Dave McNally vs Jim Duckworth | Eighth | 25½ out |
| Sunday, August 29 |
| » Defeated Orioles (70-57), 5-4 | Robert F. Kennedy Stadium (29-34) | 58-73 | Won 3 |
| » Starters: Milt Pappas vs Buster Narum | Eighth | 24½ out |
| Tuesday, August 31 |
| » Lost to Red Sox (50-83), 4-0 | Robert F. Kennedy Stadium (29-35) | 58-74 | |
| » Starters: Dave Morehead vs Pete Richert | Eighth | 25½ out |
| » Lost to Red Sox (51-83), 8-5 | Robert F. Kennedy Stadium (29-36) | 58-75 | Lost 2 |
| » Starters: Dennis Bennett vs Howie Koplitz | Eighth | 25½ out |
| Wednesday, September 1 |
| » Defeated Red Sox (51-84), 8-7 | Robert F. Kennedy Stadium (30-36) | 59-75 | |
| » Starters: Jim Lonborg vs Frank Kreutzer | Eighth | 25½ out |
| Thursday, September 2 |
| » Defeated Red Sox (51-85), 5-4 | Robert F. Kennedy Stadium (31-36) | 60-75 | Won 2 |
| » Starters: Earl Wilson vs Mike McCormick | Eighth | 24½ out |
| Friday, September 3 |
| » Lost to Tigers (75-60), 10-2 | Tiger Stadium (2-4) | 60-76 | |
| » Starters: Buster Narum vs Hank Aguirre | Eighth | 25½ out |
| Saturday, September 4 |
| » Defeated Tigers (75-61), 1-0 | Tiger Stadium (3-4) | 61-76 | |
| » Starters: Jim Duckworth vs Dave Wickersham | Eighth | 24½ out |
| Sunday, September 5 |
| » Defeated Tigers (75-62), 2-1 | Tiger Stadium (4-4) | 62-76 | Won 2 |
| » Starters: Pete Richert vs Mickey Lolich | Eighth | 24 out |
| » Lost to Tigers (76-62), 11-2 | Tiger Stadium (4-5) | 62-77 | |
| » Starters: Phil Ortega vs Phil Regan | Eighth | 24 out |
| Monday, September 6 |
| » Lost to Indians (75-62), 5-3 | Cleveland Stadium (2-6) | 62-78 | Lost 2 |
| » Starters: Pete Craig vs Sonny Siebert | Eighth | 25 out |
| » Lost to Indians (76-62), 4-3 | Cleveland Stadium (2-7) | 62-79 | Lost 3 |
| » Starters: Frank Kreutzer vs Luis Tiant | Eighth | 25 out |
| Tuesday, September 7 |
| » Major-league debuts: Mike Jurewicz and Roy White (Yankees) |
| Wednesday, September 8 |
| » Lost to Yankees (69-75), 6-5 | Yankee Stadium (3-6) | 62-80 | Lost 4 |
| » Starters: Jim Duckworth vs Jim Bouton | Eighth | 26 out |
| » Major-league debuts: Bobby Murcer (Yankees) |
| Friday, September 10 |
| » Defeated Angels (66-78), 4-1 | Robert F. Kennedy Stadium (32-36) | 63-80 | |
| » Starters: Marcelino Lopez vs Pete Richert | Eighth | 26½ out |
| Saturday, September 11 |
| » Lost to Angels (67-78), 6-5 | Robert F. Kennedy Stadium (32-37) | 63-81 | |
| » Starters: George Brunet vs Buster Narum | Eighth | 27½ out |
| » Major-league debuts: Brant Alyea (Senators) |
| Sunday, September 12 |
| » Defeated Angels (67-79), 7-1 | Robert F. Kennedy Stadium (33-37) | 64-81 | |
| » Starters: Dean Chance vs Frank Kreutzer | Eighth | 27½ out |
| » Major-league debuts: Jim French (Senators) |
| Tuesday, September 14 |
| » Lost to Yankees (72-76), 3-1 | Robert F. Kennedy Stadium (33-38) | 64-82 | |
| » Starters: Rich Beck vs Jim Duckworth | Eighth | 28½ out |
| » Major-league debuts: Rich Beck (Yankees) |
| Wednesday, September 15 |
| » Lost to Yankees (73-76), 5-3 | Robert F. Kennedy Stadium (33-39) | 64-83 | Lost 2 |
| » Starters: Mel Stottlemyre vs Pete Craig | Eighth | 29½ out |
| Thursday, September 16 |
| » Major-league debuts: Jim Ray (Astros) |
| Friday, September 17 |
| » Defeated Twins (94-55), 2-1 | Metropolitan Stadium (2-5) | 65-83 | |
| » Starters: Pete Richert vs Camilo Pascual | Eighth | 28½ out |
| Saturday, September 18 |
| » Lost to Twins (95-55), 4-2 | Metropolitan Stadium (2-6) | 65-84 | |
| » Starters: Phil Ortega vs Jim Kaat | Eighth | 29½ out |
| » Major-league debuts: Paul Casanova (Senators) |
| Sunday, September 19 |
| » Lost to Twins (96-55), 8-1 | Metropolitan Stadium (2-7) | 65-85 | Lost 2 |
| » Starters: Frank Kreutzer vs Jim Perry | Eighth | 30½ out |
| Tuesday, September 21 |
| » Defeated Athletics (55-95), 4-3 | Municipal Stadium (4-3) | 66-85 | |
| » Starters: Jim Duckworth vs Rollie Sheldon | Eighth | 29 out |
| Wednesday, September 22 |
| » Defeated Athletics (55-96), 8-2 | Municipal Stadium (5-3) | 67-85 | Won 2 |
| » Starters: Pete Richert vs Ron Tompkins | Eighth | 28 out |
| Thursday, September 23 |
| » Lost to Athletics (56-96), 8-7 | Municipal Stadium (5-4) | 67-86 | |
| » Starters: Mike McCormick vs Fred Talbot | Eighth | 28½ out |
| Saturday, September 25 |
| » Lost to Twins (97-58), 5-0 | Robert F. Kennedy Stadium (33-40) | 67-87 | Lost 2 |
| » Starters: Mudcat Grant vs Frank Kreutzer | Eighth | 30½ out |
| » Lost to Twins (98-58), 5-3 | Robert F. Kennedy Stadium (33-41) | 67-88 | Lost 3 |
| » Starters: Camilo Pascual vs Jim Duckworth | Eighth | 30½ out |
| Sunday, September 26 |
| » Lost to Twins (99-58), 2-1 | Robert F. Kennedy Stadium (33-42) | 67-89 | Lost 4 |
| » Starters: Jim Kaat vs Pete Richert | Eighth | 31½ out |
| Tuesday, September 28 |
| » Defeated Athletics (58-99), 6-1 | Robert F. Kennedy Stadium (34-42) | 68-89 | |
| » Starters: Catfish Hunter vs Joe Coleman | Eighth | 31 out |
| » Lost to Athletics (59-99), 8-6 | Robert F. Kennedy Stadium (34-43) | 68-90 | |
| » Starters: John O'Donoghue vs Pete Craig | Eighth | 31 out |
| » Major-league debuts: Joe Coleman (Senators) |
| Wednesday, September 29 |
| » Defeated Athletics (59-100), 9-0 | Robert F. Kennedy Stadium (35-43) | 69-90 | |
| » Starters: Diego Segui vs Jim Hannan | Eighth | 31 out |
| Saturday, October 2 |
| » Lost to Tigers (88-72), 9-1 | Robert F. Kennedy Stadium (35-44) | 69-91 | |
| » Starters: Denny McLain vs Jim Duckworth | Eighth | 32 out |
| » Lost to Tigers (89-72), 6-2 | Robert F. Kennedy Stadium (35-45) | 69-92 | Lost 2 |
| » Starters: Mickey Lolich vs Pete Richert | Eighth | 32 out |
| Sunday, October 3 |
| » Defeated Tigers (89-73), 3-2 | Robert F. Kennedy Stadium (36-45) | 70-92 | |
| » Starters: Joe Sparma vs Joe Coleman | Eighth | 32 out |
| Tuesday, October 5 |
| Former Senator Wid Matthews dies in Hollywood, CA at the age of 69. |
| Sunday, November 14 |
| Former Senator Dixie Walker dies in Leeds, AL at the age of 79. |
| Sunday, December 19 |
| Former Senator John Knight dies in Walnut Creek, CA at the age of 81. |
Game information provided by Retrosheet (www.retrosheet.org) |