| Saturday, January 2 |
| Future Red Sox Greg Swindell is born in Fort Worth, TX. |
| Wednesday, February 10 |
| Future Red Sox Lenny Webster is born in New Orleans, LA. |
| Saturday, March 6 |
| Former Red Sox Wally Schang dies in St.Louis, MO at the age of 76. |
| Monday, April 12 |
| » Defeated Senators (0-1), 7-2 | Robert F. Kennedy Stadium (1-0) | 1-0 | |
| » Starters: Bill Monbouquette vs Phil Ortega | First | -- |
| Wednesday, April 14 |
| » Lost to Senators (1-1), 6-4 | Robert F. Kennedy Stadium (1-1) | 1-1 | |
| » Starters: Earl Wilson vs Buster Narum | Third | 1 out |
| Saturday, April 17 |
| » Defeated Orioles (1-2), 12-9 | Fenway Park (1-0) | 2-1 | |
| » Starters: Robin Roberts vs Bill Monbouquette | Second | ½ out |
| » Major-league debuts: Jim Palmer (Orioles) |
| Sunday, April 18 |
| » Defeated Orioles (1-3), 11-4 | Fenway Park (2-0) | 3-1 | Won 2 |
| » Starters: Wally Bunker vs Earl Wilson | Second | ½ out |
| » Major-league debuts: Darold Knowles (Orioles) |
| Tuesday, April 20 |
| » Defeated Senators (3-4), 5-2 | Fenway Park (3-0) | 4-1 | Won 3 |
| » Starters: Buster Narum vs Dave Morehead | First | -- |
| Wednesday, April 21 |
| » Lost to White Sox (5-3), 3-1 | Fenway Park (3-1) | 4-2 | |
| » Starters: John Buzhardt vs Bill Monbouquette | Third | ½ out |
| Friday, April 23 |
| » Lost to Orioles (4-4), 4-2 | Memorial Stadium (0-1) | 4-3 | Lost 2 |
| » Starters: Jim Lonborg vs Robin Roberts | Fourth | 2 out |
| » Major-league debuts: Jim Lonborg (Red Sox) |
| Saturday, April 24 |
| » Defeated Orioles (4-5), 7-5 | Memorial Stadium (1-1) | 5-3 | |
| » Starters: Earl Wilson vs Milt Pappas | Fourth | 1 out |
| Tuesday, April 27 |
| » Lost to White Sox (8-3), 10-1 | Comiskey Park I (0-1) | 5-4 | |
| » Starters: Bill Monbouquette vs John Buzhardt | Fourth | 2 out |
| Friday, April 30 |
| » Lost to Tigers (8-4), 4-1 | Tiger Stadium (0-1) | 5-5 | Lost 2 |
| » Starters: Dave Morehead vs Hank Aguirre | Fifth | 2½ out |
| Saturday, May 1 |
| » Lost to Tigers (9-4), 9-8 | Tiger Stadium (0-2) | 5-6 | Lost 3 |
| » Starters: Jim Lonborg vs Dave Wickersham | Fifth | 3 out |
| Sunday, May 2 |
| » Defeated Tigers (9-5), 2-1 | Tiger Stadium (1-2) | 6-6 | |
| » Starters: Earl Wilson vs Phil Regan | Fifth | 2 out |
| » Defeated Tigers (9-6), 10-3 | Tiger Stadium (2-2) | 7-6 | Won 2 |
| » Starters: Bill Monbouquette vs Joe Sparma | Fifth | 2 out |
| Monday, May 3 |
| » Lost to Angels (9-8), 1-0 | Dodger Stadium (0-1) | 7-7 | |
| » Starters: Jerry Stephenson vs Dean Chance | Seventh | 2½ out |
| Tuesday, May 4 |
| » Lost to Angels (10-8), 7-1 | Dodger Stadium (0-2) | 7-8 | Lost 2 |
| » Starters: Dave Morehead vs Marcelino Lopez | Eighth | 3½ out |
| Wednesday, May 5 |
| » Lost to Angels (11-8), 6-4 | Dodger Stadium (0-3) | 7-9 | Lost 3 |
| » Starters: Jim Lonborg vs Fred Newman | Seventh | 5 out |
| Friday, May 7 |
| » Lost to Indians (9-7), 5-1 | Fenway Park (3-2) | 7-10 | Lost 4 |
| » Starters: Luis Tiant vs Earl Wilson | Seventh | 6 out |
| Saturday, May 8 |
| » Defeated Indians (9-8), 15-8 | Fenway Park (4-2) | 8-10 | |
| » Starters: Jack Kralick vs Bill Monbouquette | Seventh | 5 out |
| » Major-league debuts: Mike Hedlund (Indians) |
| Sunday, May 9 |
| » Lost to Indians (10-8), 9-4 | Fenway Park (4-3) | 8-11 | |
| » Starters: Sam McDowell vs Dave Morehead | Ninth | 5½ out |
| » Lost to Indians (11-8), 10-7 | Fenway Park (4-4) | 8-12 | Lost 2 |
| » Starters: Sonny Siebert vs Jerry Stephenson | Ninth | 5½ out |
| » Major-league debuts: Gerry Moses (Red Sox) |
| Monday, May 10 |
| » Defeated Yankees (9-14), 3-2 | Fenway Park (5-4) | 9-12 | |
| » Starters: Bill Stafford vs Jim Lonborg | Seventh | 5 out |
| Tuesday, May 11 |
| » Lost to Yankees (10-14), 5-3 | Fenway Park (5-5) | 9-13 | |
| » Starters: Mel Stottlemyre vs Earl Wilson | Eighth | 6 out |
| Wednesday, May 12 |
| » Defeated Yankees (10-15), 2-0 | Fenway Park (6-5) | 10-13 | |
| » Starters: Jim Bouton vs Bill Monbouquette | Seventh | 6 out |
| Thursday, May 13 |
| » Defeated Yankees (10-16), 4-1 | Fenway Park (7-5) | 11-13 | Won 2 |
| » Starters: Whitey Ford vs Dave Morehead | Seventh | 5½ out |
| » Major-league debuts: Horace Clarke (Yankees) |
| Friday, May 14 |
| » Lost to Tigers (15-11), 12-8 | Fenway Park (7-6) | 11-14 | |
| » Starters: Denny McLain vs Dennis Bennett | Seventh | 6½ out |
| Saturday, May 15 |
| » Lost to Tigers (16-11), 6-2 | Fenway Park (7-7) | 11-15 | Lost 2 |
| » Starters: Mickey Lolich vs Jim Lonborg | Eighth | 7½ out |
| Sunday, May 16 |
| » Defeated Tigers (16-12), 5-0 | Fenway Park (8-7) | 12-15 | |
| » Starters: Dave Wickersham vs Earl Wilson | Sixth | 7½ out |
| » Defeated Tigers (16-13), 4-3 | Fenway Park (9-7) | 13-15 | Won 2 |
| » Starters: Joe Sparma vs Bill Monbouquette | Sixth | 7½ out |
| Tuesday, May 18 |
| » Lost to Yankees (13-18), 4-3 | Yankee Stadium (0-1) | 13-16 | |
| » Starters: Dave Morehead vs Bill Stafford | Seventh | 9 out |
| Future Red Sox Erik Hanson is born in Kinnelon, NJ. |
| Wednesday, May 19 |
| » Defeated Yankees (13-19), 3-0 | Yankee Stadium (1-1) | 14-16 | |
| » Starters: Jim Lonborg vs Al Downing | Seventh | 8 out |
| Thursday, May 20 |
| » Lost to Yankees (14-19), 6-3 | Yankee Stadium (1-2) | 14-17 | |
| » Starters: Bill Monbouquette vs Mel Stottlemyre | Seventh | 8½ out |
| Future Red Sox Wayne Housie is born in Hampton, VA. |
| Friday, May 21 |
| » Lost to Indians (17-13), 11-6 | Cleveland Stadium (0-1) | 14-18 | Lost 2 |
| » Starters: Earl Wilson vs Luis Tiant | Seventh | 8½ out |
| Saturday, May 22 |
| » Defeated Indians (17-14), 8-4 | Cleveland Stadium (1-1) | 15-18 | |
| » Starters: Dave Morehead vs Ralph Terry | Seventh | 7½ out |
| Sunday, May 23 |
| » Defeated Indians (17-15), 6-2 | Cleveland Stadium (2-1) | 16-18 | Won 2 |
| » Starters: Jim Lonborg vs Sam McDowell | Seventh | 7 out |
| » Defeated Indians (17-16), 8-3 | Cleveland Stadium (3-1) | 17-18 | Won 3 |
| » Starters: Jerry Stephenson vs Dick Donovan | Seventh | 7 out |
| Former Red Sox Earl Webb dies in Jamestown, TN at the age of 68. |
| Tuesday, May 25 |
| » Lost to Twins (22-13), 17-5 | Fenway Park (9-8) | 17-19 | |
| » Starters: Mudcat Grant vs Bill Monbouquette | Seventh | 6½ out |
| Wednesday, May 26 |
| » Lost to Twins (23-13), 9-7 | Fenway Park (9-9) | 17-20 | Lost 2 |
| » Starters: Camilo Pascual vs Earl Wilson | Seventh | 6½ out |
| Thursday, May 27 |
| » Defeated Twins (23-14), 2-0 | Fenway Park (10-9) | 18-20 | |
| » Starters: Jim Kaat vs Dave Morehead | Seventh | 6 out |
| Friday, May 28 |
| » Defeated Athletics (10-26), 9-3 | Fenway Park (11-9) | 19-20 | Won 2 |
| » Starters: Fred Talbot vs Jim Lonborg | Seventh | 6 out |
| Saturday, May 29 |
| » Major-league debuts: Barry Moore (Senators) |
| Former Red Sox Mike McNally dies in Bethlehem, PA at the age of 73. |
| Sunday, May 30 |
| » Defeated Athletics (10-27), 3-2 | Fenway Park (12-9) | 20-20 | Won 3 |
| » Starters: Rollie Sheldon vs Bill Monbouquette | Sixth | 6 out |
| Monday, May 31 |
| » Lost to Angels (24-23), 5-3 | Fenway Park (12-10) | 20-21 | |
| » Starters: Dean Chance vs Earl Wilson | Sixth | 6 out |
| » Defeated Angels (24-24), 3-0 | Fenway Park (13-10) | 21-21 | |
| » Starters: Rudy May vs Dennis Bennett | Sixth | 6 out |
| Tuesday, June 1 |
| » Lost to Angels (25-24), 4-1 | Fenway Park (13-11) | 21-22 | |
| » Starters: George Brunet vs Dave Morehead | Seventh | 6½ out |
| Wednesday, June 2 |
| » Lost to Twins (28-15), 6-3 | Metropolitan Stadium (0-1) | 21-23 | Lost 2 |
| » Starters: Jim Lonborg vs Mudcat Grant | Seventh | 7½ out |
| Thursday, June 3 |
| » Lost to Twins (29-15), 4-3 | Metropolitan Stadium (0-2) | 21-24 | Lost 3 |
| » Starters: Bill Monbouquette vs Camilo Pascual | Seventh | 8½ out |
| Saturday, June 5 |
| » Defeated Athletics (10-31), 5-3 | Municipal Stadium (1-0) | 22-24 | |
| » Starters: Earl Wilson vs Diego Segui | Seventh | 8½ out |
| » Major-league debuts: Jesse Hickman (Athletics) |
| Sunday, June 6 |
| » Defeated Athletics (10-32), 9-4 | Municipal Stadium (2-0) | 23-24 | Won 2 |
| » Starters: Dave Morehead vs Don Buschhorn | Seventh | 9 out |
| » Lost to Athletics (11-32), 4-3 | Municipal Stadium (2-1) | 23-25 | |
| » Starters: Dennis Bennett vs Rollie Sheldon | Seventh | 9 out |
| Monday, June 7 |
| » Lost to White Sox (29-19), 7-3 | Fenway Park (13-12) | 23-26 | Lost 2 |
| » Starters: John Buzhardt vs Jim Lonborg | Seventh | 9 out |
| Tuesday, June 8 |
| » Lost to White Sox (30-19), 7-2 | Fenway Park (13-13) | 23-27 | Lost 3 |
| » Starters: Joe Horlen vs Bill Monbouquette | Seventh | 10 out |
| Wednesday, June 9 |
| » Defeated White Sox (30-20), 4-2 | Fenway Park (14-13) | 24-27 | |
| » Starters: Bruce Howard vs Earl Wilson | Seventh | 9 out |
| Thursday, June 10 |
| » Lost to White Sox (31-20), 4-2 | Fenway Park (14-14) | 24-28 | |
| » Starters: Gary Peters vs Dave Morehead | Seventh | 9 out |
| Friday, June 11 |
| » Lost to Orioles (29-25), 5-4 | Fenway Park (14-15) | 24-29 | Lost 2 |
| » Starters: Robin Roberts vs Dennis Bennett | Eighth | 10½ out |
| Saturday, June 12 |
| » Lost to Orioles (30-25), 5-4 | Fenway Park (14-16) | 24-30 | Lost 3 |
| » Starters: Jim Palmer vs Jim Lonborg | Eighth | 10½ out |
| Sunday, June 13 |
| » Lost to Orioles (31-25), 1-0 | Fenway Park (14-17) | 24-31 | Lost 4 |
| » Starters: Milt Pappas vs Bill Monbouquette | Eighth | 10½ out |
| Tuesday, June 15 |
| » Lost to Tigers (30-25), 6-5 | Tiger Stadium (2-3) | 24-32 | Lost 5 |
| » Starters: Earl Wilson vs Dave Wickersham | Eighth | 11½ out |
| Wednesday, June 16 |
| » Lost to Tigers (31-25), 9-4 | Tiger Stadium (2-4) | 24-33 | Lost 6 |
| » Starters: Dave Morehead vs Mickey Lolich | Eighth | 11½ out |
| Thursday, June 17 |
| » Lost to Tigers (32-25), 6-5 | Tiger Stadium (2-5) | 24-34 | Lost 7 |
| » Starters: Jerry Stephenson vs Joe Sparma | Eighth | 12½ out |
| Friday, June 18 |
| » Lost to White Sox (36-23), 4-3 | Comiskey Park I (0-2) | 24-35 | Lost 8 |
| » Starters: Jim Lonborg vs Juan Pizarro | Ninth | 12½ out |
| Saturday, June 19 |
| » Defeated White Sox (36-24), 2-1 | Comiskey Park I (1-2) | 25-35 | |
| » Starters: Bill Monbouquette vs Bruce Howard | Eighth | 11½ out |
| Sunday, June 20 |
| » Lost to White Sox (37-24), 4-3 | Comiskey Park I (1-3) | 25-36 | |
| » Starters: Dennis Bennett vs Gary Peters | Eighth | 13 out |
| Tuesday, June 22 |
| » Lost to Orioles (37-26), 4-1 | Memorial Stadium (1-2) | 25-37 | Lost 2 |
| » Starters: Dave Morehead vs John Miller | Seventh | 12½ out |
| » Defeated Orioles (37-27), 4-2 | Memorial Stadium (2-2) | 26-37 | |
| » Starters: Earl Wilson vs Robin Roberts | Seventh | 12½ out |
| Wednesday, June 23 |
| » Lost to Orioles (38-27), 6-4 | Memorial Stadium (2-3) | 26-38 | |
| » Starters: Jim Lonborg vs Steve Barber | Eighth | 13½ out |
| Thursday, June 24 |
| » Lost to Orioles (39-27), 4-1 | Memorial Stadium (2-4) | 26-39 | Lost 2 |
| » Starters: Bill Monbouquette vs Milt Pappas | Eighth | 13½ out |
| Friday, June 25 |
| » Defeated Senators (27-41), 8-6 | Fenway Park (15-17) | 27-39 | |
| » Starters: Buster Narum vs Dennis Bennett | Seventh | 13½ out |
| Saturday, June 26 |
| » Lost to Senators (28-41), 12-7 | Fenway Park (15-18) | 27-40 | |
| » Starters: Howie Koplitz vs Dave Morehead | Eighth | 13½ out |
| Sunday, June 27 |
| » Defeated Senators (28-42), 4-1 | Fenway Park (16-18) | 28-40 | |
| » Starters: Bennie Daniels vs Jim Lonborg | Seventh | 13½ out |
| » Defeated Senators (28-43), 5-4 | Fenway Park (17-18) | 29-40 | Won 2 |
| » Starters: Frank Kreutzer vs Earl Wilson | Seventh | 13½ out |
| Monday, June 28 |
| » Lost to Indians (42-26), 9-2 | Fenway Park (17-19) | 29-41 | |
| » Starters: Luis Tiant vs Bill Monbouquette | Seventh | 14 out |
| Tuesday, June 29 |
| » Lost to Indians (43-26), 8-5 | Fenway Park (17-20) | 29-42 | Lost 2 |
| » Starters: Ralph Terry vs Dennis Bennett | Eighth | 15 out |
| Thursday, July 1 |
| » Lost to Tigers (40-31), 2-1 | Fenway Park (17-21) | 29-43 | Lost 3 |
| » Starters: Mickey Lolich vs Earl Wilson | Eighth | 15½ out |
| Friday, July 2 |
| » Lost to Yankees (37-39), 16-2 | Fenway Park (17-22) | 29-44 | Lost 4 |
| » Starters: Mel Stottlemyre vs Dave Morehead | Ninth | 16½ out |
| Saturday, July 3 |
| » Lost to Yankees (38-39), 6-2 | Fenway Park (17-23) | 29-45 | Lost 5 |
| » Starters: Al Downing vs Jim Lonborg | Eighth | 16½ out |
| Sunday, July 4 |
| » Defeated Yankees (38-40), 5-3 | Fenway Park (18-23) | 30-45 | |
| » Starters: Jim Bouton vs Bill Monbouquette | Eighth | 16½ out |
| Monday, July 5 |
| » Lost to Twins (47-28), 6-2 | Metropolitan Stadium (0-3) | 30-46 | |
| » Starters: Earl Wilson vs Dave Boswell | Ninth | 18½ out |
| » Lost to Twins (48-28), 2-0 | Metropolitan Stadium (0-4) | 30-47 | Lost 2 |
| » Starters: Dave Morehead vs Jim Perry | Ninth | 18½ out |
| Tuesday, July 6 |
| » Lost to Twins (49-28), 9-0 | Metropolitan Stadium (0-5) | 30-48 | Lost 3 |
| » Starters: Jerry Stephenson vs Mudcat Grant | Ninth | 19½ out |
| Wednesday, July 7 |
| » Lost to Twins (50-28), 5-2 | Metropolitan Stadium (0-6) | 30-49 | Lost 4 |
| » Starters: Jim Lonborg vs Jim Kaat | Ninth | 20½ out |
| Friday, July 9 |
| » Lost to Senators (35-49), 2-1 | Robert F. Kennedy Stadium (1-2) | 30-50 | Lost 5 |
| » Starters: Bill Monbouquette vs Pete Richert | Ninth | 21 out |
| » Defeated Senators (35-50), 10-1 | Robert F. Kennedy Stadium (2-2) | 31-50 | |
| » Starters: Earl Wilson vs Buster Narum | Ninth | 21 out |
| Saturday, July 10 |
| » Lost to Senators (36-50), 5-3 | Robert F. Kennedy Stadium (2-3) | 31-51 | |
| » Starters: Dave Morehead vs Phil Ortega | Ninth | 21½ out |
| Thursday, July 15 |
| » Lost to Indians (49-35), 6-3 | Cleveland Stadium (3-2) | 31-52 | Lost 2 |
| » Starters: Jim Lonborg vs Sonny Siebert | Ninth | 22½ out |
| Friday, July 16 |
| » Lost to Indians (50-35), 4-3 | Cleveland Stadium (3-3) | 31-53 | Lost 3 |
| » Starters: Bill Monbouquette vs Sam McDowell | Ninth | 22½ out |
| Saturday, July 17 |
| » Lost to Indians (51-35), 8-5 | Cleveland Stadium (3-4) | 31-54 | Lost 4 |
| » Starters: Earl Wilson vs Luis Tiant | Ninth | 22½ out |
| Sunday, July 18 |
| » Defeated Indians (51-36), 4-1 | Cleveland Stadium (4-4) | 32-54 | |
| » Starters: Dave Morehead vs Jack Kralick | Seventh | 22 out |
| Monday, July 19 |
| » Defeated Yankees (44-48), 3-1 | Yankee Stadium (2-2) | 33-54 | Won 2 |
| » Starters: Jim Lonborg vs Jim Bouton | Eighth | 22 out |
| Tuesday, July 20 |
| » Lost to Yankees (45-48), 6-3 | Yankee Stadium (2-3) | 33-55 | |
| » Starters: Bill Monbouquette vs Mel Stottlemyre | Eighth | 22 out |
| Wednesday, July 21 |
| » Lost to Twins (57-34), 8-6 | Fenway Park (18-24) | 33-56 | Lost 2 |
| » Starters: Jim Kaat vs Earl Wilson | Ninth | 24 out |
| » Lost to Twins (58-34), 11-8 | Fenway Park (18-25) | 33-57 | Lost 3 |
| » Starters: Dick Stigman vs Bob Heffner | Ninth | 24 out |
| Former Red Sox Hugh Bedient dies in Jamestown, NY at the age of 76. |
| Thursday, July 22 |
| » Lost to Twins (59-34), 11-5 | Fenway Park (18-26) | 33-58 | Lost 4 |
| » Starters: Mudcat Grant vs Dave Morehead | Ninth | 25 out |
| Friday, July 23 |
| » Lost to Angels (45-50), 7-3 | Fenway Park (18-27) | 33-59 | Lost 5 |
| » Starters: Fred Newman vs Jim Lonborg | Ninth | 25 out |
| Saturday, July 24 |
| » Defeated Angels (45-51), 8-5 | Fenway Park (19-27) | 34-59 | |
| » Starters: Dean Chance vs Bill Monbouquette | Ninth | 24 out |
| Sunday, July 25 |
| » Defeated Angels (45-52), 5-4 | Fenway Park (20-27) | 35-59 | Won 2 |
| » Starters: Marcelino Lopez vs Earl Wilson | Ninth | 24 out |
| Monday, July 26 |
| » Lost to Angels (46-52), 6-2 | Fenway Park (20-28) | 35-60 | |
| » Starters: George Brunet vs Dave Morehead | Ninth | 25 out |
| Tuesday, July 27 |
| » Lost to Athletics (31-61), 7-3 | Fenway Park (20-29) | 35-61 | Lost 2 |
| » Starters: Fred Talbot vs Jerry Stephenson | Ninth | 26 out |
| » Lost to Athletics (32-61), 10-8 | Fenway Park (20-30) | 35-62 | Lost 3 |
| » Starters: Catfish Hunter vs Jim Lonborg | Ninth | 26 out |
| Wednesday, July 28 |
| » Defeated Athletics (32-62), 6-0 | Fenway Park (21-30) | 36-62 | |
| » Starters: Rollie Sheldon vs Bill Monbouquette | Ninth | 26 out |
| Thursday, July 29 |
| » Defeated Athletics (32-63), 6-4 | Fenway Park (22-30) | 37-62 | Won 2 |
| » Starters: Diego Segui vs Earl Wilson | Ninth | 25½ out |
| Future Red Sox Luis Alicea is born in Santurce, P.R. |
| Friday, July 30 |
| » Lost to Angels (47-54), 9-2 | Dodger Stadium (0-4) | 37-63 | |
| » Starters: Dave Morehead vs Dean Chance | Eighth | 26½ out |
| Saturday, July 31 |
| » Defeated Angels (47-55), 4-3 | Dodger Stadium (1-4) | 38-63 | |
| » Starters: Jim Lonborg vs Marcelino Lopez | Eighth | 26½ out |
| Sunday, August 1 |
| » Lost to Angels (48-55), 5-4 | Dodger Stadium (1-5) | 38-64 | |
| » Starters: Bill Monbouquette vs George Brunet | Ninth | 26½ out |
| Monday, August 2 |
| » Major-league debuts: Jim Merritt (Twins) |
| Tuesday, August 3 |
| » Defeated Athletics (34-66), 10-5 | Municipal Stadium (3-1) | 39-64 | |
| » Starters: Earl Wilson vs Diego Segui | Ninth | 26½ out |
| Wednesday, August 4 |
| » Defeated Athletics (34-67), 5-1 | Municipal Stadium (4-1) | 40-64 | Won 2 |
| » Starters: Dave Morehead vs John O'Donoghue | Ninth | 26½ out |
| Thursday, August 5 |
| » Lost to Athletics (35-67), 5-1 | Municipal Stadium (4-2) | 40-65 | |
| » Starters: Jim Lonborg vs Fred Talbot | Ninth | 27½ out |
| Friday, August 6 |
| » Lost to Twins (70-39), 9-3 | Metropolitan Stadium (0-7) | 40-66 | Lost 2 |
| » Starters: Bill Monbouquette vs Jim Merritt | Ninth | 28½ out |
| Saturday, August 7 |
| » Lost to Twins (71-39), 9-4 | Metropolitan Stadium (0-8) | 40-67 | Lost 3 |
| » Starters: Earl Wilson vs Mudcat Grant | Eighth | 29½ out |
| Sunday, August 8 |
| » Lost to Twins (72-39), 8-0 | Metropolitan Stadium (0-9) | 40-68 | Lost 4 |
| » Starters: Dave Morehead vs Jim Perry | Eighth | 30½ out |
| Tuesday, August 10 |
| » Defeated Orioles (63-47), 15-5 | Fenway Park (23-30) | 41-68 | |
| » Starters: Milt Pappas vs Jim Lonborg | Eighth | 31 out |
| » Lost to Orioles (64-47), 12-4 | Fenway Park (23-31) | 41-69 | |
| » Starters: John Miller vs Bill Monbouquette | Eighth | 31 out |
| Wednesday, August 11 |
| » Defeated Orioles (64-48), 8-3 | Fenway Park (24-31) | 42-69 | |
| » Starters: Steve Barber vs Earl Wilson | Ninth | 30 out |
| Thursday, August 12 |
| » Lost to Orioles (65-48), 5-3 | Fenway Park (24-32) | 42-70 | |
| » Starters: Dave McNally vs Dave Morehead | Eighth | 31 out |
| Friday, August 13 |
| » Defeated White Sox (61-51), 3-2 | Fenway Park (25-32) | 43-70 | |
| » Starters: John Buzhardt vs Dennis Bennett | Eighth | 30 out |
| Future Red Sox Mark Lemke is born in Utica, NY. |
| Saturday, August 14 |
| » Lost to White Sox (62-51), 5-3 | Fenway Park (25-33) | 43-71 | |
| » Starters: Bruce Howard vs Jim Lonborg | Ninth | 30 out |
| Sunday, August 15 |
| » Lost to White Sox (63-51), 7-4 | Fenway Park (25-34) | 43-72 | Lost 2 |
| » Starters: Tommy John vs Bill Monbouquette | Eighth | 30½ out |
| Monday, August 16 |
| » Lost to White Sox (64-51), 5-4 | Fenway Park (25-35) | 43-73 | Lost 3 |
| » Starters: Joe Horlen vs Earl Wilson | Eighth | 31 out |
| Tuesday, August 17 |
| » Lost to Orioles (66-51), 3-1 | Memorial Stadium (2-5) | 43-74 | Lost 4 |
| » Starters: Dave Morehead vs Steve Barber | Seventh | 31 out |
| Future Red Sox Alex Cole is born in Fayetteville, NC. |
| Wednesday, August 18 |
| » Lost to Orioles (67-51), 3-2 | Memorial Stadium (2-6) | 43-75 | Lost 5 |
| » Starters: Dennis Bennett vs Dave McNally | Eighth | 31½ out |
| Thursday, August 19 |
| » Defeated Orioles (67-52), 11-3 | Memorial Stadium (3-6) | 44-75 | |
| » Starters: Jim Lonborg vs Wally Bunker | Seventh | 32 out |
| Friday, August 20 |
| » Lost to Tigers (68-52), 2-0 | Fenway Park (25-36) | 44-76 | |
| » Starters: Denny McLain vs Bill Monbouquette | Eighth | 33 out |
| » Lost to Tigers (69-52), 3-2 | Fenway Park (25-37) | 44-77 | Lost 2 |
| » Starters: Joe Sparma vs Earl Wilson | Eighth | 33 out |
| Saturday, August 21 |
| » Defeated Tigers (69-53), 13-10 | Fenway Park (26-37) | 45-77 | |
| » Starters: Hank Aguirre vs Dave Morehead | Ninth | 33 out |
| Former Red Sox Bill Harris dies in Indian Trail, NC at the age of 66. |
| Sunday, August 22 |
| » Lost to Tigers (70-53), 2-1 | Fenway Park (26-38) | 45-78 | |
| » Starters: Joe Sparma vs Dennis Bennett | Ninth | 33 out |
| Tuesday, August 24 |
| » Defeated Senators (54-71), 9-4 | Fenway Park (27-38) | 46-78 | |
| » Starters: Buster Narum vs Jim Lonborg | Ninth | 33 out |
| » Lost to Senators (55-71), 8-5 | Fenway Park (27-39) | 46-79 | |
| » Starters: Jim Duckworth vs Bill Monbouquette | Ninth | 33 out |
| Wednesday, August 25 |
| » Defeated Senators (55-72), 8-3 | Fenway Park (28-39) | 47-79 | |
| » Starters: Mike McCormick vs Earl Wilson | Ninth | 33 out |
| Thursday, August 26 |
| » Defeated Senators (55-73), 4-2 | Fenway Park (29-39) | 48-79 | Won 2 |
| » Starters: Phil Ortega vs Dave Morehead | Ninth | 33 out |
| Future Red Sox Carlos Quintana is born in Estado Miranda, Venezuela. Future Red Sox Jeff Richardson is born in Grand Island, NE. |
| Friday, August 27 |
| » Lost to White Sox (73-54), 3-2 | Comiskey Park I (1-4) | 48-80 | |
| » Starters: Jerry Stephenson vs Joe Horlen | Ninth | 33½ out |
| » Defeated White Sox (73-55), 6-1 | Comiskey Park I (2-4) | 49-80 | |
| » Starters: Dennis Bennett vs John Buzhardt | Ninth | 33½ out |
| Saturday, August 28 |
| » Lost to White Sox (74-55), 5-3 | Comiskey Park I (2-5) | 49-81 | |
| » Starters: Jim Lonborg vs Juan Pizarro | Ninth | 33½ out |
| Sunday, August 29 |
| » Lost to White Sox (75-55), 3-2 | Comiskey Park I (2-6) | 49-82 | Lost 2 |
| » Starters: Bill Monbouquette vs Bruce Howard | Ninth | 34 out |
| » Lost to White Sox (76-55), 3-2 | Comiskey Park I (2-7) | 49-83 | Lost 3 |
| » Starters: Earl Wilson vs Gary Peters | Ninth | 34 out |
| Tuesday, August 31 |
| » Defeated Senators (58-74), 4-0 | Robert F. Kennedy Stadium (3-3) | 50-83 | |
| » Starters: Dave Morehead vs Pete Richert | Ninth | 33 out |
| » Defeated Senators (58-75), 8-5 | Robert F. Kennedy Stadium (4-3) | 51-83 | Won 2 |
| » Starters: Dennis Bennett vs Howie Koplitz | Ninth | 33 out |
| Wednesday, September 1 |
| » Lost to Senators (59-75), 8-7 | Robert F. Kennedy Stadium (4-4) | 51-84 | |
| » Starters: Jim Lonborg vs Frank Kreutzer | Ninth | 34 out |
| Thursday, September 2 |
| » Lost to Senators (60-75), 5-4 | Robert F. Kennedy Stadium (4-5) | 51-85 | Lost 2 |
| » Starters: Earl Wilson vs Mike McCormick | Ninth | 34 out |
| Future Red Sox Jose Melendez is born in Naguabo, P.R. |
| Friday, September 3 |
| » Lost to Yankees (68-68), 9-0 | Yankee Stadium (2-4) | 51-86 | Lost 3 |
| » Starters: Bill Monbouquette vs Al Downing | Tenth | 35 out |
| Saturday, September 4 |
| » Defeated Yankees (68-69), 1-0 | Yankee Stadium (3-4) | 52-86 | |
| » Starters: Dave Morehead vs Jim Bouton | Ninth | 33½ out |
| » Defeated Yankees (68-70), 7-2 | Yankee Stadium (4-4) | 53-86 | Won 2 |
| » Starters: Dennis Bennett vs Jack Cullen | Ninth | 33½ out |
| Sunday, September 5 |
| » Defeated Yankees (68-71), 4-3 | Yankee Stadium (5-4) | 54-86 | Won 3 |
| » Starters: Jim Lonborg vs Mel Stottlemyre | Ninth | 32½ out |
| Monday, September 6 |
| » Defeated Tigers (76-63), 4-1 | Tiger Stadium (3-5) | 55-86 | Won 4 |
| » Starters: Earl Wilson vs Joe Sparma | Ninth | 32 out |
| » Major-league debuts: John Hiller (Tigers) |
| Tuesday, September 7 |
| » Lost to Tigers (77-63), 5-3 | Tiger Stadium (3-6) | 55-87 | |
| » Starters: Bill Monbouquette vs Julio Navarro | Ninth | 32½ out |
| » Major-league debuts: Wayne Redmond (Tigers) |
| Wednesday, September 8 |
| » Defeated Indians (77-63), 5-3 | Cleveland Stadium (5-4) | 56-87 | |
| » Starters: Dennis Bennett vs Sam McDowell | Ninth | 32½ out |
| Friday, September 10 |
| » Lost to Twins (90-54), 8-5 | Fenway Park (29-40) | 56-88 | |
| » Starters: Jim Perry vs Dave Morehead | Ninth | 34 out |
| Saturday, September 11 |
| » Lost to Twins (91-54), 8-4 | Fenway Park (29-41) | 56-89 | Lost 2 |
| » Starters: Camilo Pascual vs Jim Lonborg | Ninth | 35 out |
| Sunday, September 12 |
| » Lost to Twins (92-54), 2-0 | Fenway Park (29-42) | 56-90 | Lost 3 |
| » Starters: Mudcat Grant vs Earl Wilson | Ninth | 36 out |
| Monday, September 13 |
| Future Red Sox Steve Curry is born in Winter Park, FL. |
| Tuesday, September 14 |
| » Defeated Indians (77-66), 5-4 | Fenway Park (30-42) | 57-90 | |
| » Starters: Sam McDowell vs Bill Monbouquette | Ninth | 36 out |
| Wednesday, September 15 |
| » Lost to Indians (78-66), 8-4 | Fenway Park (30-43) | 57-91 | |
| » Starters: Sonny Siebert vs Dennis Bennett | Ninth | 37 out |
| Thursday, September 16 |
| » Defeated Indians (78-67), 2-0 | Fenway Park (31-43) | 58-91 | |
| » Starters: Luis Tiant vs Dave Morehead | Ninth | 36½ out |
| » Major-league debuts: Bill Davis (Indians) |
| Friday, September 17 |
| » Lost to Athletics (54-92), 8-7 | Fenway Park (31-44) | 58-92 | |
| » Starters: Rollie Sheldon vs Jim Lonborg | Ninth | 36½ out |
| Saturday, September 18 |
| » Defeated Athletics (54-93), 5-3 | Fenway Park (32-44) | 59-92 | |
| » Starters: Dick Joyce vs Earl Wilson | Ninth | 36½ out |
| Sunday, September 19 |
| » Defeated Athletics (54-94), 3-2 | Fenway Park (33-44) | 60-92 | Won 2 |
| » Starters: Fred Talbot vs Bill Monbouquette | Ninth | 36½ out |
| Tuesday, September 21 |
| » Lost to Angels (71-81), 4-0 | Dodger Stadium (1-6) | 60-93 | |
| » Starters: Dennis Bennett vs Fred Newman | Ninth | 36 out |
| Wednesday, September 22 |
| » Lost to Angels (72-81), 10-1 | Dodger Stadium (1-7) | 60-94 | Lost 2 |
| »</ |
