| Saturday, January 2 |
| Future Indian Greg Swindell is born in Fort Worth, TX. |
| Monday, January 4 |
| Future Indian Kevin Wickander is born in Fort Dodge, IA. |
| Tuesday, January 19 |
| Former Indian Jim Joe Edwards dies in Sarepta, MS at the age of 71. |
| Friday, February 12 |
| Future Indian Ruben Amaro, Jr. is born in Philadelphia, PA. |
| Sunday, March 7 |
| Future Indian Jack Armstrong is born in Englewood, NJ. |
| Wednesday, March 17 |
| Future Indian John Smiley is born in Phoenixville, PA. |
| Thursday, March 18 |
| Future Indian Geronimo Berroa is born in Santo Domingo, D.R. |
| Monday, March 22 |
| Future Indian Glenallen Hill is born in Santa Cruz, CA. |
| Saturday, April 10 |
| Future Indian Bruce Egloff is born in Denver, CO. |
| Sunday, April 11 |
| Future Indian Turner Ward is born in Orlando, FL. |
| Tuesday, April 13 |
| » Defeated Angels (0-1), 7-1 | Dodger Stadium (1-0) | 1-0 | |
| » Starters: Ralph Terry vs Fred Newman | Second | ½ out |
| » Major-league debuts: Dick Wantz (Angels) |
| Thursday, April 15 |
| » Lost to Athletics (1-2), 7-3 | Municipal Stadium (0-1) | 1-1 | |
| » Starters: Sam McDowell vs John O'Donoghue | Third | 1½ out |
| Saturday, April 17 |
| » Lost to Twins (2-1), 3-0 | Metropolitan Stadium (0-1) | 1-2 | Lost 2 |
| » Starters: Dick Donovan vs Jim Kaat | Fourth | 1½ out |
| Future Indian Craig Worthington is born in Los Angeles, CA. |
| Sunday, April 18 |
| » Lost to Twins (3-1), 6-3 | Metropolitan Stadium (0-2) | 1-3 | Lost 3 |
| » Starters: Ralph Terry vs Mudcat Grant | Sixth | 2½ out |
| Wednesday, April 21 |
| » Defeated Angels (3-4), 6-5 | Cleveland Stadium (1-0) | 2-3 | |
| » Starters: Fred Newman vs Sam McDowell | Sixth | 2 out |
| Friday, April 23 |
| » Defeated Athletics (2-6), 6-2 | Cleveland Stadium (2-0) | 3-3 | Won 2 |
| » Starters: Orlando Pena vs Dick Donovan | Fifth | 2½ out |
| Saturday, April 24 |
| » Defeated Athletics (2-7), 4-1 | Cleveland Stadium (3-0) | 4-3 | Won 3 |
| » Starters: Moe Drabowsky vs Ralph Terry | Fifth | 1½ out |
| Tuesday, April 27 |
| » Lost to Twins (7-2), 11-1 | Cleveland Stadium (3-1) | 4-4 | |
| » Starters: Camilo Pascual vs Sam McDowell | Fifth | 2½ out |
| Wednesday, April 28 |
| » Defeated Twins (7-3), 9-3 | Cleveland Stadium (4-1) | 5-4 | |
| » Starters: Jim Kaat vs Jack Kralick | Fourth | 2 out |
| Friday, April 30 |
| » Defeated Senators (4-11), 5-2 | Cleveland Stadium (5-1) | 6-4 | Won 2 |
| » Starters: Buster Narum vs Ralph Terry | Third | 1½ out |
| Saturday, May 1 |
| » Defeated Senators (4-12), 7-2 | Cleveland Stadium (6-1) | 7-4 | Won 3 |
| » Starters: Bennie Daniels vs Luis Tiant | Third | 1 out |
| Sunday, May 2 |
| » Lost to Senators (5-12), 3-2 | Cleveland Stadium (6-2) | 7-5 | |
| » Starters: Mike McCormick vs Jack Kralick | Fifth | 2 out |
| » Lost to Senators (6-12), 4-2 | Cleveland Stadium (6-3) | 7-6 | Lost 2 |
| » Starters: Dallas Green vs Sam McDowell | Fifth | 2 out |
| Tuesday, May 4 |
| » Lost to Yankees (8-9), 5-3 | Cleveland Stadium (6-4) | 7-7 | Lost 3 |
| » Starters: Jim Bouton vs Sonny Siebert | Sixth | 3 out |
| Wednesday, May 5 |
| » Defeated Yankees (8-10), 4-0 | Cleveland Stadium (7-4) | 8-7 | |
| » Starters: Whitey Ford vs Ralph Terry | Fourth | 3½ out |
| Friday, May 7 |
| » Defeated Red Sox (7-10), 5-1 | Fenway Park (1-0) | 9-7 | Won 2 |
| » Starters: Luis Tiant vs Earl Wilson | Fourth | 3½ out |
| Saturday, May 8 |
| » Lost to Red Sox (8-10), 15-8 | Fenway Park (1-1) | 9-8 | |
| » Starters: Jack Kralick vs Bill Monbouquette | Fourth | 3½ out |
| » Major-league debuts: Mike Hedlund (Indians) |
| Sunday, May 9 |
| » Defeated Red Sox (8-11), 9-4 | Fenway Park (2-1) | 10-8 | |
| » Starters: Sam McDowell vs Dave Morehead | Fourth | 2 out |
| » Defeated Red Sox (8-12), 10-7 | Fenway Park (3-1) | 11-8 | Won 2 |
| » Starters: Sonny Siebert vs Jerry Stephenson | Fourth | 2 out |
| » Major-league debuts: Gerry Moses (Red Sox) |
| Tuesday, May 11 |
| » Lost to Orioles (13-11), 3-2 | Memorial Stadium (0-1) | 11-9 | |
| » Starters: Ralph Terry vs Steve Barber | Fourth | 3 out |
| Wednesday, May 12 |
| » Lost to Orioles (14-11), 4-2 | Memorial Stadium (0-2) | 11-10 | Lost 2 |
| » Starters: Luis Tiant vs Dave McNally | Sixth | 4 out |
| Thursday, May 13 |
| » Lost to Orioles (15-11), 3-2 | Memorial Stadium (0-3) | 11-11 | Lost 3 |
| » Starters: Jack Kralick vs Milt Pappas | Sixth | 4½ out |
| Friday, May 14 |
| » Defeated Senators (10-18), 2-1 | Robert F. Kennedy Stadium (1-0) | 12-11 | |
| » Starters: Sam McDowell vs Phil Ortega | Sixth | 4½ out |
| Future Indian Joey Cora is born in Caguas, P.R. |
| Saturday, May 15 |
| » Lost to Senators (11-18), 9-7 | Robert F. Kennedy Stadium (1-1) | 12-12 | |
| » Starters: Sonny Siebert vs Buster Narum | Sixth | 5½ out |
| Sunday, May 16 |
| » Lost to Senators (12-18), 8-7 | Robert F. Kennedy Stadium (1-2) | 12-13 | Lost 2 |
| » Starters: Ralph Terry vs Mike McCormick | Fifth | 6½ out |
| » Defeated Senators (12-19), 7-3 | Robert F. Kennedy Stadium (2-2) | 13-13 | |
| » Starters: Luis Tiant vs Frank Kreutzer | Fifth | 6½ out |
| Tuesday, May 18 |
| » Defeated Orioles (17-14), 1-0 | Cleveland Stadium (8-4) | 14-13 | Won 2 |
| » Starters: Robin Roberts vs Jack Kralick | Sixth | 7 out |
| Wednesday, May 19 |
| » Defeated Orioles (17-15), 2-0 | Cleveland Stadium (9-4) | 15-13 | Won 3 |
| » Starters: Steve Barber vs Sam McDowell | Fourth | 6 out |
| Thursday, May 20 |
| » Defeated Orioles (17-16), 5-2 | Cleveland Stadium (10-4) | 16-13 | Won 4 |
| » Starters: Dave McNally vs Sonny Siebert | Fourth | 5½ out |
| Friday, May 21 |
| » Defeated Red Sox (14-18), 11-6 | Cleveland Stadium (11-4) | 17-13 | Won 5 |
| » Starters: Earl Wilson vs Luis Tiant | Third | 4½ out |
| Saturday, May 22 |
| » Lost to Red Sox (15-18), 8-4 | Cleveland Stadium (11-5) | 17-14 | |
| » Starters: Dave Morehead vs Ralph Terry | Fourth | 4½ out |
| Sunday, May 23 |
| » Lost to Red Sox (16-18), 6-2 | Cleveland Stadium (11-6) | 17-15 | Lost 2 |
| » Starters: Jim Lonborg vs Sam McDowell | Sixth | 6 out |
| » Lost to Red Sox (17-18), 8-3 | Cleveland Stadium (11-7) | 17-16 | Lost 3 |
| » Starters: Jerry Stephenson vs Dick Donovan | Sixth | 6 out |
| Monday, May 24 |
| » Lost to Yankees (17-21), 15-5 | Yankee Stadium (0-1) | 17-17 | Lost 4 |
| » Starters: Jack Kralick vs Mel Stottlemyre | Sixth | 6 out |
| Tuesday, May 25 |
| » Defeated Yankees (17-22), 5-1 | Yankee Stadium (1-1) | 18-17 | |
| » Starters: Sonny Siebert vs Jim Bouton | Fifth | 5 out |
| Wednesday, May 26 |
| » Defeated White Sox (24-14), 3-1 | Comiskey Park I (1-0) | 19-17 | Won 2 |
| » Starters: Luis Tiant vs Gary Peters | Fifth | 4 out |
| Thursday, May 27 |
| » Major-league debuts: Tom Egan (Angels) |
| Friday, May 28 |
| » Lost to Tigers (23-17), 1-0 | Tiger Stadium (0-1) | 19-18 | |
| » Starters: Ralph Terry vs Hank Aguirre | Fifth | 5 out |
| Saturday, May 29 |
| » Lost to Tigers (24-17), 1-0 | Tiger Stadium (0-2) | 19-19 | Lost 2 |
| » Starters: Jack Kralick vs Mickey Lolich | Sixth | 6 out |
| Sunday, May 30 |
| » Defeated Tigers (24-18), 10-2 | Tiger Stadium (1-2) | 20-19 | |
| » Starters: Sam McDowell vs Phil Regan | Fifth | 5½ out |
| Monday, May 31 |
| » Lost to White Sox (27-15), 4-3 | Cleveland Stadium (11-8) | 20-20 | |
| » Starters: John Buzhardt vs Sonny Siebert | Fifth | 5½ out |
| » Defeated White Sox (27-16), 4-3 | Cleveland Stadium (12-8) | 21-20 | |
| » Starters: Juan Pizarro vs Luis Tiant | Fifth | 5½ out |
| Friday, June 4 |
| » Defeated Tigers (25-20), 7-6 | Cleveland Stadium (13-8) | 22-20 | Won 2 |
| » Starters: Hank Aguirre vs Ralph Terry | Fifth | 6½ out |
| Future Indian Beau Allred is born in Mesa, AZ. |
| Saturday, June 5 |
| » Defeated Tigers (25-21), 2-1 | Cleveland Stadium (14-8) | 23-20 | Won 3 |
| » Starters: Mickey Lolich vs Sam McDowell | Fifth | 6 out |
| Sunday, June 6 |
| » Defeated Tigers (25-22), 10-1 | Cleveland Stadium (15-8) | 24-20 | Won 4 |
| » Starters: Joe Sparma vs Jack Kralick | Third | 6 out |
| Monday, June 7 |
| » Defeated Twins (31-16), 2-1 | Metropolitan Stadium (1-2) | 25-20 | Won 5 |
| » Starters: Luis Tiant vs Mudcat Grant | Third | 5 out |
| Tuesday, June 8 |
| » Lost to Twins (32-16), 6-2 | Metropolitan Stadium (1-3) | 25-21 | |
| » Starters: Sonny Siebert vs Camilo Pascual | Third | 6 out |
| Wednesday, June 9 |
| » Defeated Twins (32-17), 2-1 | Metropolitan Stadium (2-3) | 26-21 | |
| » Starters: Ralph Terry vs Jim Kaat | Third | 5 out |
| Thursday, June 10 |
| » Defeated Twins (32-18), 4-1 | Metropolitan Stadium (3-3) | 27-21 | Won 2 |
| » Starters: Sam McDowell vs Dave Boswell | Third | 4 out |
| Friday, June 11 |
| » Lost to Athletics (13-34), 5-2 | Municipal Stadium (0-2) | 27-22 | |
| » Starters: Jack Kralick vs Rollie Sheldon | Third | 5½ out |
| Saturday, June 12 |
| » Lost to Athletics (14-34), 7-0 | Municipal Stadium (0-3) | 27-23 | Lost 2 |
| » Starters: Luis Tiant vs Fred Talbot | Fourth | 5½ out |
| Sunday, June 13 |
| » Lost to Athletics (15-34), 8-4 | Municipal Stadium (0-4) | 27-24 | Lost 3 |
| » Starters: Sonny Siebert vs Don Buschhorn | Fourth | 5 out |
| » Defeated Athletics (15-35), 5-2 | Municipal Stadium (1-4) | 28-24 | |
| » Starters: Lee Stange vs John O'Donoghue | Fourth | 5 out |
| Monday, June 14 |
| » Defeated Yankees (26-30), 5-4 | Cleveland Stadium (16-8) | 29-24 | Won 2 |
| » Starters: Bill Stafford vs Ralph Terry | Fourth | 4½ out |
| Tuesday, June 15 |
| » Defeated Senators (25-35), 8-3 | Cleveland Stadium (17-8) | 30-24 | Won 3 |
| » Starters: Howie Koplitz vs Sam McDowell | Fourth | 4½ out |
| Wednesday, June 16 |
| » Defeated Senators (25-36), 5-0 | Cleveland Stadium (18-8) | 31-24 | Won 4 |
| » Starters: Phil Ortega vs Luis Tiant | Fourth | 3½ out |
| Thursday, June 17 |
| » Defeated Senators (25-37), 5-0 | Cleveland Stadium (19-8) | 32-24 | Won 5 |
| » Starters: Bennie Daniels vs Sonny Siebert | Fourth | 3½ out |
| Friday, June 18 |
| » Defeated Angels (31-33), 3-2 | Cleveland Stadium (20-8) | 33-24 | Won 6 |
| » Starters: Rudy May vs Lee Stange | Third | 2½ out |
| Saturday, June 19 |
| » Defeated Angels (31-34), 1-0 | Cleveland Stadium (21-8) | 34-24 | Won 7 |
| » Starters: Fred Newman vs Ralph Terry | Third | 1½ out |
| Sunday, June 20 |
| » Defeated Angels (31-35), 5-0 | Cleveland Stadium (22-8) | 35-24 | Won 8 |
| » Starters: Marcelino Lopez vs Sam McDowell | Third | 1½ out |
| » Defeated Angels (31-36), 3-1 | Cleveland Stadium (23-8) | 36-24 | Won 9 |
| » Starters: Dean Chance vs Lee Stange | Third | 1½ out |
| Tuesday, June 22 |
| » Defeated Twins (38-24), 5-4 | Cleveland Stadium (24-8) | 37-24 | Won 10 |
| » Starters: Jim Kaat vs Luis Tiant | Second | ½ out |
| Wednesday, June 23 |
| » Lost to Twins (39-24), 6-3 | Cleveland Stadium (24-9) | 37-25 | |
| » Starters: Mudcat Grant vs Sonny Siebert | Third | 1½ out |
| Thursday, June 24 |
| » Defeated Twins (39-25), 3-1 | Cleveland Stadium (25-9) | 38-25 | |
| » Starters: Camilo Pascual vs Ralph Terry | Second | ½ out |
| Friday, June 25 |
| » Defeated Athletics (19-43), 2-0 | Cleveland Stadium (26-9) | 39-25 | Won 2 |
| » Starters: Catfish Hunter vs Sam McDowell | Second | ½ out |
| Saturday, June 26 |
| » Lost to Athletics (20-43), 4-2 | Cleveland Stadium (26-10) | 39-26 | |
| » Starters: Fred Talbot vs Lee Stange | Second | ½ out |
| Sunday, June 27 |
| » Defeated Athletics (20-44), 10-7 | Cleveland Stadium (27-10) | 40-26 | |
| » Starters: John O'Donoghue vs Luis Tiant | Second | ½ out |
| » Defeated Athletics (20-45), 11-7 | Cleveland Stadium (28-10) | 41-26 | Won 2 |
| » Starters: Wes Stock vs Floyd Weaver | Second | ½ out |
| Monday, June 28 |
| » Defeated Red Sox (29-41), 9-2 | Fenway Park (4-1) | 42-26 | Won 3 |
| » Starters: Luis Tiant vs Bill Monbouquette | First | -- |
| Tuesday, June 29 |
| » Defeated Red Sox (29-42), 8-5 | Fenway Park (5-1) | 43-26 | Won 4 |
| » Starters: Ralph Terry vs Dennis Bennett | First | -- |
| Wednesday, June 30 |
| » Lost to Senators (30-45), 2-1 | Robert F. Kennedy Stadium (2-3) | 43-27 | |
| » Starters: Sam McDowell vs Phil Ortega | First | -- |
| Thursday, July 1 |
| » Defeated Senators (30-46), 7-2 | Robert F. Kennedy Stadium (3-3) | 44-27 | |
| » Starters: Sonny Siebert vs Howie Koplitz | First | -- |
| Friday, July 2 |
| » Defeated Orioles (42-33), 8-0 | Memorial Stadium (1-3) | 45-27 | Won 2 |
| » Starters: Lee Stange vs John Miller | First | -- |
| Saturday, July 3 |
| » Lost to Orioles (43-33), 8-4 | Memorial Stadium (1-4) | 45-28 | |
| » Starters: Luis Tiant vs Wally Bunker | First | -- |
| Sunday, July 4 |
| » Defeated Orioles (43-34), 4-2 | Cleveland Stadium (29-10) | 46-28 | |
| » Starters: Milt Pappas vs Ralph Terry | First | -- |
| Monday, July 5 |
| » Lost to White Sox (44-31), 3-1 | Comiskey Park I (1-1) | 46-29 | |
| » Starters: Sam McDowell vs Bruce Howard | Second | 1½ out |
| Wednesday, July 7 |
| » Defeated White Sox (44-32), 4-2 | Comiskey Park I (2-1) | 47-29 | |
| » Starters: Luis Tiant vs Gary Peters | Second | 1½ out |
| » Defeated White Sox (44-33), 4-2 | Comiskey Park I (3-1) | 48-29 | Won 2 |
| » Starters: Lee Stange vs John Buzhardt | Second | 1½ out |
| Thursday, July 8 |
| » Lost to White Sox (45-33), 3-2 | Comiskey Park I (3-2) | 48-30 | |
| » Starters: Jack Kralick vs Tommy John | Second | 2 out |
| Friday, July 9 |
| » Lost to Angels (38-44), 4-3 | Dodger Stadium (1-1) | 48-31 | Lost 2 |
| » Starters: Ralph Terry vs George Brunet | Second | 3½ out |
| » Lost to Angels (39-44), 2-0 | Dodger Stadium (1-2) | 48-32 | Lost 3 |
| » Starters: Sonny Siebert vs Marcelino Lopez | Second | 3½ out |
| Saturday, July 10 |
| » Lost to Angels (40-44), 1-0 | Dodger Stadium (1-3) | 48-33 | Lost 4 |
| » Starters: Sam McDowell vs Fred Newman | Second | 4 out |
| Sunday, July 11 |
| » Lost to Angels (41-44), 2-0 | Dodger Stadium (1-4) | 48-34 | Lost 5 |
| » Starters: Lee Stange vs Dean Chance | Second | 5 out |
| Wednesday, July 14 |
| » Lost to White Sox (47-35), 12-10 | Cleveland Stadium (29-11) | 48-35 | Lost 6 |
| » Starters: Gary Peters vs Ralph Terry | Third | 5½ out |
| Thursday, July 15 |
| » Defeated Red Sox (31-52), 6-3 | Cleveland Stadium (30-11) | 49-35 | |
| » Starters: Jim Lonborg vs Sonny Siebert | Second | 5 out |
| Friday, July 16 |
| » Defeated Red Sox (31-53), 4-3 | Cleveland Stadium (31-11) | 50-35 | Won 2 |
| » Starters: Bill Monbouquette vs Sam McDowell | Second | 4 out |
| Saturday, July 17 |
| » Defeated Red Sox (31-54), 8-5 | Cleveland Stadium (32-11) | 51-35 | Won 3 |
| » Starters: Earl Wilson vs Luis Tiant | Second | 3 out |
| Sunday, July 18 |
| » Lost to Red Sox (32-54), 4-1 | Cleveland Stadium (32-12) | 51-36 | |
| » Starters: Dave Morehead vs Jack Kralick | Second | 3½ out |
| Monday, July 19 |
| » Defeated Orioles (51-37), 5-0 | Cleveland Stadium (33-12) | 52-36 | |
| » Starters: Steve Barber vs Lee Stange | Second | 3½ out |
| Tuesday, July 20 |
| » Lost to Orioles (52-37), 6-1 | Cleveland Stadium (33-13) | 52-37 | |
| » Starters: Dave McNally vs Ralph Terry | Second | 3½ out |
| Wednesday, July 21 |
| » Lost to Tigers (49-39), 10-5 | Tiger Stadium (1-3) | 52-38 | Lost 2 |
| » Starters: Sam McDowell vs Mickey Lolich | Fourth | 5½ out |
| » Lost to Tigers (50-39), 2-1 | Tiger Stadium (1-4) | 52-39 | Lost 3 |
| » Starters: Sonny Siebert vs Denny McLain | Fourth | 5½ out |
| Friday, July 23 |
| » Defeated Yankees (47-49), 5-2 | Cleveland Stadium (34-13) | 53-39 | |
| » Starters: Jim Bouton vs Luis Tiant | Third | 5 out |
| Saturday, July 24 |
| » Defeated Yankees (47-50), 3-0 | Cleveland Stadium (35-13) | 54-39 | Won 2 |
| » Starters: Pete Mikkelsen vs Sam McDowell | Third | 4 out |
| Sunday, July 25 |
| » Lost to Yankees (48-50), 3-0 | Cleveland Stadium (35-14) | 54-40 | |
| » Starters: Mel Stottlemyre vs Sonny Siebert | Third | 4½ out |
| » Defeated Yankees (48-51), 7-4 | Cleveland Stadium (36-14) | 55-40 | |
| » Starters: Al Downing vs Lee Stange | Third | 4½ out |
| Future Indian Torey Lovullo is born in Santa Monica, CA. |
| Tuesday, July 27 |
| » Defeated White Sox (52-43), 7-3 | Cleveland Stadium (37-14) | 56-40 | Won 2 |
| » Starters: John Buzhardt vs Ralph Terry | Third | 4½ out |
| Wednesday, July 28 |
| » Defeated White Sox (52-44), 4-2 | Cleveland Stadium (38-14) | 57-40 | Won 3 |
| » Starters: Joe Horlen vs Sam McDowell | Third | 4½ out |
| Thursday, July 29 |
| » Lost to White Sox (53-44), 9-4 | Cleveland Stadium (38-15) | 57-41 | |
| » Starters: Tommy John vs Luis Tiant | Third | 5 out |
| Friday, July 30 |
| » Defeated Yankees (50-54), 5-0 | Yankee Stadium (2-1) | 58-41 | |
| » Starters: Sonny Siebert vs Al Downing | Second | 5 out |
| Saturday, July 31 |
| » Lost to Yankees (51-54), 7-6 | Yankee Stadium (2-2) | 58-42 | |
| » Starters: Luis Tiant vs Whitey Ford | Second | 6 out |
| Sunday, August 1 |
| » Lost to Yankees (52-54), 10-6 | Yankee Stadium (2-3) | 58-43 | Lost 2 |
| » Starters: Ralph Terry vs Jim Bouton | Third | 5½ out |
| » Defeated Yankees (52-55), 4-1 | Yankee Stadium (3-3) | 59-43 | |
| » Starters: Sam McDowell vs Jack Cullen | Third | 5½ out |
| Tuesday, August 3 |
| » Lost to Tigers (58-45), 12-7 | Cleveland Stadium (38-16) | 59-44 | |
| » Starters: Mickey Lolich vs Steve Hargan | Third | 6½ out |
| » Major-league debuts: Steve Hargan (Indians) |
| Wednesday, August 4 |
| » Defeated Tigers (58-46), 4-1 | Cleveland Stadium (39-16) | 60-44 | |
| » Starters: Joe Sparma vs Sonny Siebert | Third | 6½ out |
| Future Indian Matt Merullo is born in Winchester, MA. |
| Thursday, August 5 |
| » Defeated Tigers (58-47), 5-2 | Cleveland Stadium (40-16) | 61-44 | Won 2 |
| » Starters: Dave Wickersham vs Sam McDowell | Third | 6½ out |
| Friday, August 6 |
| » Lost to White Sox (58-48), 11-5 | Comiskey Park I (3-3) | 61-45 | |
| » Starters: Ralph Terry vs Joe Horlen | Third | 7½ out |
| Saturday, August 7 |
| » Lost to White Sox (59-48), 4-3 | Comiskey Park I (3-4) | 61-46 | Lost 2 |
| » Starters: Luis Tiant vs John Buzhardt | Third | 8½ out |
| Sunday, August 8 |
| » Defeated White Sox (59-49), 6-4 | Comiskey Park I (4-4) | 62-46 | |
| » Starters: Sonny Siebert vs Gary Peters | Third | 8½ out |
| Monday, August 9 |
| » Lost to Angels (50-60), 9-0 | Cleveland Stadium (40-17) | 62-47 | |
| » Starters: Dean Chance vs Sam McDowell | Third | 9 out |
| Tuesday, August 10 |
| » Lost to Angels (51-60), 5-2 | Cleveland Stadium (40-18) | 62-48 | Lost 2 |
| » Starters: Marcelino Lopez vs Steve Hargan | Third | 10 out |
| Wednesday, August 11 |
| » Defeated Angels (51-61), 6-0 | Cleveland Stadium (41-18) | 63-48 | |
| » Starters: George Brunet vs Luis Tiant | Third | 9 out |
| Thursday, August 12 |
| » Lost to Angels (52-61), 5-1 | Cleveland Stadium (41-19) | 63-49 | |
| » Starters: Fred Newman vs Jack Kralick | Third | 10 out |
| Friday, August 13 |
| » Defeated Twins (74-41), 3-1 | Cleveland Stadium (42-19) | 64-49 | |
| » Starters: Jim Perry vs Sonny Siebert | Third | 9 out |
| » Major-league debuts: Andy Kosco (Twins) |
| Saturday, August 14 |
| » Defeated Twins (74-42), 3-1 | Cleveland Stadium (43-19) | 65-49 | Won 2 |
| » Starters: Jim Kaat vs Sam McDowell | Second | 8 out |
| Sunday, August 15 |
| » Lost to Twins (75-42), 4-3 | Cleveland Stadium (43-20) | 65-50 | |
| » Starters: Mudcat Grant vs Luis Tiant | Second | 8 out |
| » Defeated Twins (75-43), 6-4 | Cleveland Stadium (44-20) | 66-50 | |
| » Starters: Dick Stigman vs Steve Hargan | Second | 8 out |
| Former Indian Stan Pitula dies in Hackensack, NJ at the age of 35. |
| Tuesday, August 17 |
| » Lost to Athletics (40-75), 3-2 | Cleveland Stadium (44-21) | 66-51 | |
| » Starters: Lew Krausse vs Lee Stange | Third | 8 out |
| Future Indian Alex Cole is born in Fayetteville, NC. |
| Wednesday, August 18 |
| » Lost to Athletics (41-75), 4-2 | Cleveland Stadium (44-22) | 66-52 | Lost 2 |
| » Starters: John O'Donoghue vs Sam McDowell | Fourth | 8 out |
| » Defeated Athletics (41-76), 4-1 | Cleveland Stadium (45-22) | 67-52 | |
| » Starters: Fred Talbot vs Jack Kralick | Fourth | 8 out |
| Friday, August 20 |
| » Lost to Senators (53-69), 3-2 | Robert F. Kennedy Stadium (3-4) | 67-53 | |
| » Starters: Luis Tiant vs Buster Narum | Fourth | 9½ out |
| Saturday, August 21 |
| » Lost to Senators (54-69), 4-2 | Robert F. Kennedy Stadium (3-5) | 67-54 | Lost 2 |
| » Starters: Steve Hargan vs Mike McCormick | Fifth | 10½ out |
| Sunday, August 22 |
| » Defeated Senators (54-70), 8-5 | Robert F. Kennedy Stadium (4-5) | 68-54 | |
| » Starters: Sam McDowell vs Phil Ortega | Fifth | 9½ out |
| Monday, August 23 |
| » Lost to Angels (57-68), 8-2 | Dodger Stadium (1-5) | 68-55 | |
| » Starters: Jack Kralick vs Marcelino Lopez | Fifth | 10½ out |
| Tuesday, August 24 |
| » Lost to Angels (58-68), 7-1 | Dodger Stadium (1-6) | 68-56 | Lost 2 |
| » Starters: Luis Tiant vs George Brunet | Fifth | 10½ out |
| Wednesday, August 25 |
| » Defeated Angels (58-69), 6-3 | Dodger Stadium (2-6) | 69-56 | |
| » Starters: Steve Hargan vs Jack Sanford | Fifth | 10 out |
| » Defeated Angels (58-70), 8-2 | Dodger Stadium (3-6) | 70-56 | Won 2 |
| » Starters: Ralph Terry vs Fred Newman | Fifth | 10 out |
| Friday, August 27 |
| » Lost to Twins (83-47), 7-0 | Metropolitan Stadium (3-4) | 70-57 | |
| » Starters: Sam McDowell vs Mudcat Grant | Fifth | 11½ out |
| Saturday, August 28 |
| » Defeated Twins (83-48), 6-5 | Metropolitan Stadium (4-4) | 71-57 | |
| » Starters: Luis Tiant vs Jim Perry | Fourth | 10½ out |
| Sunday, August 29 |
| » Defeated Twins (83-49), 3-1 | Metropolitan Stadium (5-4) | 72-57 | Won 2 |
| » Starters: Steve Hargan vs Jim Merritt | Third | 9½ out |
| Monday, August 30 |
| Former Indian Frank Papish dies in Pueblo, CO at the age of 48. |
| Tuesday, August 31 |
| » Defeated Athletics (46-83), 8-1 | Municipal Stadium (2-4) | 73-57 | Won 3 |
| » Starters: Sam McDowell vs Catfish Hunter | Fourth | 9½ out |
| » Lost to Athletics (47-83), 3-2 | Municipal Stadium (2-5) | 73-58 | |
| » Starters: Sonny Siebert vs Fred Talbot | Fourth | 9½ out |
| Wednesday, September 1 |
| » Lost to Athletics (48-83), 4-3 | Municipal Stadium (2-6) | 73-59 | Lost 2 |
| » Starters: Luis Tiant vs John O'Donoghue | Fourth | 10½ out |
| » Major-league debuts: Richie Scheinblum (Indians) |
| Former Indian Ivy Olson dies in Inglewood, CA at the age of 80. |
| Thursday, September 2 |
| » Defeated Athletics (48-84), 10-6 | Municipal Stadium (3-6) | 74-59 | |
| » Starters: Ralph Terry vs Rollie Sheldon | Third | 9½ out |
| Friday, September 3 |
| » Lost to Orioles (73-59), 5-3 | Memorial Stadium (1-5) | 74-60 | |
| » Starters: Steve Hargan vs Wally Bunker | Fifth | 10½ out |
| Saturday, September 4 |
| » Lost to Orioles (74-59), 1-0 | Memorial Stadium (1-6) | 74-61 | Lost 2 |
| » Starters: Sam McDowell vs Steve Barber | Fifth | 10½ out |
| Sunday, September 5 |
| » Lost to Orioles (75-59), 9-5 | Memorial Stadium (1-7) | 74-62 | Lost 3 |
| » Starters: Lee Stange vs John Miller | Fifth | 10½ out |
| Monday, September 6 |
| » Defeated Senators (62-78), 5-3 | Cleveland Stadium (46-22) | 75-62 | |
| » Starters: Pete Craig vs Sonny Siebert | Fourth | 9½ out |
| » Defeated Senators (62-79), 4-3 | Cleveland Stadium (47-22) | 76-62 | Won 2 |
| » Starters: Frank Kreutzer vs Luis Tiant | Fourth | 9½ out |
| Tuesday, September 7 |
| » Defeated White Sox (82-59), 9-5 | Comiskey Park I (5-4) | 77-62 | Won 3 |
| » Starters: Jack Kralick vs Juan Pizarro | Fourth | 9 out |
| Wednesday, September 8 |
| » Lost to Red Sox (56-87), 5-3 | Cleveland Stadium (47-23) | 77-63 | |
| » Starters: Dennis Bennett vs Sam McDowell | Fourth | 10 out |
| Thursday, September 9 |
| » Major-league debuts: Ron Tompkins (Athletics) |
| Friday, September 10 |
| » Lost to Tigers (79-64), 2-0 | Cleveland Stadium (47-24) | 77-64 | Lost 2 |
| » Starters: Mickey Lolich vs Sonny Siebert | Fifth | 11½ out |
| Saturday, September 11 |
| » Lost to Tigers (80-64), 5-3 | Cleveland Stadium (47-25) | 77-65 | Lost 3 |
| » Starters: Joe Sparma vs Luis Tiant | Fifth | 12½ out |
| Sunday, September 12 |
| » Major-league debuts: Jim French (Senators) |
| Tuesday, September 14 |
| » Lost to Red Sox (57-90), 5-4 | Fenway Park (5-2) | 77-66 | Lost 4 |
| » Starters: Sam McDowell vs Bill Monbouquette | Fifth | 14 out |
| Wednesday, September 15 |
| » Defeated Red Sox (57-91), 8-4 | Fenway Park (6-2) | 78-66 | |
| » Starters: Sonny Siebert vs Dennis Bennett | Fifth | 14 out |
| Thursday, September 16 |
| » Lost to Red Sox (58-91), 2-0 | Fenway Park (6-3) | 78-67 | |
| » Starters: Luis Tiant vs Dave Morehead | Fifth | 14½ out |
| » Major-league debuts: Bill Davis (Indians) |
| Friday, September 17 |
| » Lost to White Sox (85-65), 5-4 | Cleveland Stadium (47-26) | 78-68 | Lost 2 |
| » Starters: Gary Peters vs Tom Kelley | Fifth | 14½ out |
| Saturday, September 18 |
| » Lost to White Sox (86-65), 8-5 | Cleveland Stadium (47-27) | 78-69 | Lost 3 |
| » Starters: Tommy John vs Steve Hargan | Fifth | 15½ out |
| Sunday, September 19 |
| » Lost to White Sox (87-65), 7-5 | Cleveland Stadium (47-28) | 78-70 | Lost 4 |
| » Starters: Juan Pizarro vs Sonny Siebert | Fifth | 16½ out |
| Monday, September 20 |
| » Defeated Tigers (83-68), 5-4 | Cleveland Stadium (48-28) | 79-70 | |
| » Starters: Hank Aguirre vs Luis Tiant | Fifth | 15½ out |
| Tuesday, September 21 |
| » Lost to Yankees (75-78), 9-4 | Yankee Stadium (3-4) | 79-71 | |
| » Starters: Ralph Terry vs Mel Stottlemyre | Fifth | 15½ out |
| » Major-league debuts: Ralph Gagliano (Indians) |
| Wednesday, September 22 |
| » Defeated Yankees (75-79), 4-3 | Yanke |
