| Sunday, February 7 |
| Former Cardinal Bruno Betzel dies in W.Hollywood, FL at the age of 71. |
| Thursday, February 11 |
| Former Cardinal Pete Noonan dies in Great Barrington, MA at the age of 84. |
| Tuesday, March 2 |
| Future Cardinal Ron Gant is born in Victoria, TX. |
| Friday, March 5 |
| Former Cardinal Pepper Martin dies in McAlester, OK at the age of 62. |
| Friday, March 12 |
| Future Cardinal Shawn Gilbert is born in Camden, NJ. |
| Monday, April 5 |
| Future Cardinal Cris Carpenter is born in St. Augustine, FL. |
| Monday, April 12 |
| » Tied Cubs, 10-10 | Wrigley Field (0-0) | 0-0 | |
| » Manager: Red Schoendienst |
| » Starters: Bob Gibson vs Larry Jackson | Second | ½ out |
| » Major-league debuts: Glenn Beckert and Roberto Pena (Cubs) Steve Carlton (Cardinals) |
| Tuesday, April 13 |
| » Lost to Cubs (1-0), 3-1 | Wrigley Field (0-1) | 0-1 | |
| » Starters: Curt Simmons vs Bob Buhl | Fourth | 1½ out |
| Wednesday, April 14 |
| » Lost to Cubs (2-0), 7-3 | Wrigley Field (0-2) | 0-2 | Lost 2 |
| » Starters: Ray Sadecki vs Dick Ellsworth | Fifth | 2 out |
| Thursday, April 15 |
| » Lost to Reds (2-1), 10-4 | Sportsman's Park III (0-1) | 0-3 | Lost 3 |
| » Starters: John Tsitouris vs Bob Purkey | Fifth | 2½ out |
| Saturday, April 17 |
| » Defeated Reds (2-2), 8-0 | Sportsman's Park III (1-1) | 1-3 | |
| » Starters: Jim O'Toole vs Bob Gibson | Fourth | 2 out |
| » Major-league debuts: Art Shamsky (Reds) |
| Sunday, April 18 |
| » Lost to Reds (3-2), 8-2 | Sportsman's Park III (1-2) | 1-4 | |
| » Starters: Sammy Ellis vs Curt Simmons | Seventh | 2½ out |
| Monday, April 19 |
| » Lost to Cubs (4-2), 7-3 | Sportsman's Park III (1-3) | 1-5 | Lost 2 |
| » Starters: Dick Ellsworth vs Ray Sadecki | Seventh | 3 out |
| » Major-league debuts: Nellie Briles (Cardinals) |
| Wednesday, April 21 |
| » Defeated Braves (3-4), 6-3 | Sportsman's Park III (2-3) | 2-5 | |
| » Starters: Bob Sadowski vs Bob Purkey | Ninth | 3 out |
| Friday, April 23 |
| » Defeated Reds (5-4), 6-3 | Crosley Field (1-0) | 3-5 | Won 2 |
| » Starters: Bob Gibson vs John Tsitouris | Eighth | 3 out |
| Saturday, April 24 |
| » Lost to Reds (6-4), 6-3 | Crosley Field (1-1) | 3-6 | |
| » Starters: Tracy Stallard vs Sammy Ellis | Ninth | 4 out |
| Tuesday, April 27 |
| » Lost to Braves (4-5), 9-5 | County Stadium (0-1) | 3-7 | Lost 2 |
| » Starters: Bob Purkey vs Denny Lemaster | Tenth | 4 out |
| Wednesday, April 28 |
| » Defeated Braves (4-6), 5-0 | County Stadium (1-1) | 4-7 | |
| » Starters: Bob Gibson vs Wade Blasingame | Tenth | 3½ out |
| Thursday, April 29 |
| » Lost to Braves (5-6), 4-1 | County Stadium (1-2) | 4-8 | |
| » Starters: Curt Simmons vs Bob Sadowski | Tenth | 4 out |
| Friday, April 30 |
| » Defeated Pirates (6-9), 3-2 | Sportsman's Park III (3-3) | 5-8 | |
| » Starters: Vern Law vs Ray Sadecki | Ninth | 4 out |
| Saturday, May 1 |
| » Defeated Pirates (6-10), 3-2 | Sportsman's Park III (4-3) | 6-8 | Won 2 |
| » Starters: Don Cardwell vs Tracy Stallard | Sixth | 4 out |
| Former Cardinal Hy Myers dies in Minerva, OH at the age of 77. |
| Sunday, May 2 |
| » Defeated Pirates (6-11), 9-5 | Sportsman's Park III (5-3) | 7-8 | Won 3 |
| » Starters: Bob Friend vs Bob Gibson | Fourth | 3½ out |
| » Defeated Pirates (6-12), 5-4 | Sportsman's Park III (6-3) | 8-8 | Won 4 |
| » Starters: Bob Veale vs Bob Purkey | Fourth | 3½ out |
| Future Cardinal Felix Jose is born in Santo Domingo, D.R. |
| Monday, May 3 |
| » Defeated Giants (8-11), 3-1 | Sportsman's Park III (7-3) | 9-8 | Won 5 |
| » Starters: Ron Herbel vs Curt Simmons | Fourth | 3 out |
| Tuesday, May 4 |
| » Lost to Giants (9-11), 9-2 | Sportsman's Park III (7-4) | 9-9 | |
| » Starters: Juan Marichal vs Ray Sadecki | Fourth | 3 out |
| Wednesday, May 5 |
| » Lost to Giants (10-11), 10-5 | Sportsman's Park III (7-5) | 9-10 | Lost 2 |
| » Starters: Bob Hendley vs Tracy Stallard | Seventh | 4 out |
| Friday, May 7 |
| » Defeated Phillies (9-11), 2-0 | Shibe Park (1-0) | 10-10 | |
| » Starters: Bob Gibson vs Chris Short | Fifth | 4½ out |
| Saturday, May 8 |
| » Lost to Phillies (10-11), 9-8 | Shibe Park (1-1) | 10-11 | |
| » Starters: Curt Simmons vs Bo Belinsky | Fifth | 5½ out |
| Sunday, May 9 |
| » Lost to Phillies (11-11), 4-2 | Shibe Park (1-2) | 10-12 | Lost 2 |
| » Starters: Ray Sadecki vs Art Mahaffey | Eighth | 5½ out |
| Monday, May 10 |
| » Lost to Phillies (12-11), 4-2 | Shibe Park (1-3) | 10-13 | Lost 3 |
| » Starters: Tracy Stallard vs Jim Bunning | Eighth | 6½ out |
| Tuesday, May 11 |
| » Defeated Mets (9-16), 4-3 | Shea Stadium (1-0) | 11-13 | |
| » Starters: Bob Gibson vs Warren Spahn | Seventh | 5½ out |
| Wednesday, May 12 |
| » Lost to Mets (10-16), 2-1 | Shea Stadium (1-1) | 11-14 | |
| » Starters: Curt Simmons vs Jack Fisher | Seventh | 6½ out |
| Friday, May 14 |
| » Defeated Pirates (9-19), 8-7 | Forbes Field (1-0) | 12-14 | |
| » Starters: Ray Sadecki vs Joe Gibbon | Eighth | 6 out |
| Saturday, May 15 |
| » Defeated Pirates (9-20), 5-1 | Forbes Field (2-0) | 13-14 | Won 2 |
| » Starters: Tracy Stallard vs Vern Law | Sixth | 6 out |
| Sunday, May 16 |
| » Defeated Pirates (9-21), 6-3 | Forbes Field (3-0) | 14-14 | Won 3 |
| » Starters: Bob Gibson vs Don Cardwell | Fourth | 5 out |
| » Defeated Pirates (9-22), 5-1 | Forbes Field (4-0) | 15-14 | Won 4 |
| » Starters: Ray Washburn vs Bob Veale | Fourth | 5 out |
| Monday, May 17 |
| » Lost to Phillies (16-14), 2-1 | Sportsman's Park III (7-6) | 15-15 | |
| » Starters: Bo Belinsky vs Curt Simmons | Sixth | 6 out |
| Tuesday, May 18 |
| » Defeated Phillies (16-15), 8-2 | Sportsman's Park III (8-6) | 16-15 | |
| » Starters: Art Mahaffey vs Ray Sadecki | Fifth | 5 out |
| Wednesday, May 19 |
| » Defeated Phillies (16-16), 7-6 | Sportsman's Park III (9-6) | 17-15 | Won 2 |
| » Starters: Jim Bunning vs Tracy Stallard | Fourth | 5 out |
| Thursday, May 20 |
| » Defeated Phillies (16-17), 12-2 | Sportsman's Park III (10-6) | 18-15 | Won 3 |
| » Starters: Chris Short vs Bob Gibson | Fourth | 4½ out |
| Future Cardinal Todd Stottlemyre is born in Sunnyside, WA. |
| Friday, May 21 |
| » Defeated Mets (13-21), 5-4 | Sportsman's Park III (11-6) | 19-15 | Won 4 |
| » Starters: Al Jackson vs Ray Washburn | Third | 3½ out |
| Saturday, May 22 |
| » Defeated Mets (13-22), 5-1 | Sportsman's Park III (12-6) | 20-15 | Won 5 |
| » Starters: Jack Fisher vs Curt Simmons | Third | 3½ out |
| Sunday, May 23 |
| » Defeated Mets (13-23), 8-7 | Sportsman's Park III (13-6) | 21-15 | Won 6 |
| » Starters: Gary Kroll vs Ray Sadecki | Third | 2½ out |
| Monday, May 24 |
| » Defeated Dodgers (24-14), 6-4 | Dodger Stadium (1-0) | 22-15 | Won 7 |
| » Starters: Tracy Stallard vs Claude Osteen | Third | 1½ out |
| Tuesday, May 25 |
| » Lost to Dodgers (25-14), 2-0 | Dodger Stadium (1-1) | 22-16 | |
| » Starters: Bob Gibson vs Don Drysdale | Third | 2½ out |
| Wednesday, May 26 |
| » Defeated Dodgers (25-15), 2-1 | Dodger Stadium (2-1) | 23-16 | |
| » Starters: Curt Simmons vs Sandy Koufax | Third | 1½ out |
| Thursday, May 27 |
| » Lost to Astros (20-24), 6-1 | Astrodome (0-1) | 23-17 | |
| » Starters: Ray Washburn vs Turk Farrell | Third | 2½ out |
| Friday, May 28 |
| » Lost to Astros (21-24), 3-2 | Astrodome (0-2) | 23-18 | Lost 2 |
| » Starters: Ray Sadecki vs Dave Giusti | Third | 2½ out |
| Saturday, May 29 |
| » Lost to Astros (22-24), 4-3 | Astrodome (0-3) | 23-19 | Lost 3 |
| » Starters: Tracy Stallard vs Don Nottebart | Third | 3½ out |
| Sunday, May 30 |
| » Lost to Giants (25-20), 3-2 | Candlestick Park (0-1) | 23-20 | Lost 4 |
| » Starters: Bob Gibson vs Ron Herbel | Fifth | 4½ out |
| Monday, May 31 |
| » Lost to Giants (26-20), 4-1 | Candlestick Park (0-2) | 23-21 | Lost 5 |
| » Starters: Curt Simmons vs Gaylord Perry | Fifth | 5 out |
| Tuesday, June 1 |
| » Defeated Giants (26-21), 2-1 | Candlestick Park (1-2) | 24-21 | |
| » Starters: Ray Sadecki vs Juan Marichal | Fifth | 4½ out |
| Wednesday, June 2 |
| » Lost to Dodgers (30-17), 4-1 | Sportsman's Park III (13-7) | 24-22 | |
| » Starters: Don Drysdale vs Ray Washburn | Fifth | 5½ out |
| Thursday, June 3 |
| » Lost to Dodgers (31-17), 11-10 | Sportsman's Park III (13-8) | 24-23 | Lost 2 |
| » Starters: Sandy Koufax vs Bob Purkey | Fifth | 6½ out |
| Friday, June 4 |
| » Lost to Astros (25-27), 5-2 | Sportsman's Park III (13-9) | 24-24 | Lost 3 |
| » Starters: Bob Bruce vs Bob Gibson | Fifth | 6½ out |
| Saturday, June 5 |
| » Defeated Astros (25-28), 4-3 | Sportsman's Park III (14-9) | 25-24 | |
| » Starters: Larry Dierker vs Curt Simmons | Fifth | 5½ out |
| Sunday, June 6 |
| » Lost to Astros (26-28), 10-1 | Sportsman's Park III (14-10) | 25-25 | |
| » Starters: Claude Raymond vs Ray Sadecki | Fifth | 6 out |
| Tuesday, June 8 |
| » Lost to Reds (28-22), 5-4 | Sportsman's Park III (14-11) | 25-26 | Lost 2 |
| » Starters: Gerry Arrigo vs Bob Gibson | Fifth | 7½ out |
| Wednesday, June 9 |
| » Defeated Reds (28-23), 6-4 | Sportsman's Park III (15-11) | 26-26 | |
| » Starters: Joey Jay vs Curt Simmons | Fifth | 6½ out |
| Thursday, June 10 |
| » Lost to Reds (29-23), 8-7 | Sportsman's Park III (15-12) | 26-27 | |
| » Starters: Jim Maloney vs Ray Sadecki | Sixth | 6½ out |
| Friday, June 11 |
| » Lost to Braves (29-21), 8-2 | Sportsman's Park III (15-13) | 26-28 | Lost 2 |
| » Starters: Denny Lemaster vs Ray Washburn | Sixth | 7½ out |
| Saturday, June 12 |
| » Lost to Braves (30-21), 4-1 | Sportsman's Park III (15-14) | 26-29 | Lost 3 |
| » Starters: Ken Johnson vs Bob Gibson | Seventh | 8½ out |
| Sunday, June 13 |
| » Lost to Braves (31-21), 4-2 | Sportsman's Park III (15-15) | 26-30 | Lost 4 |
| » Starters: Wade Blasingame vs Curt Simmons | Seventh | 9½ out |
| » Defeated Braves (31-22), 12-2 | Sportsman's Park III (16-15) | 27-30 | |
| » Starters: Hank Fischer vs Bob Purkey | Seventh | 9½ out |
| Monday, June 14 |
| » Defeated Pirates (29-28), 5-2 | Sportsman's Park III (17-15) | 28-30 | Won 2 |
| » Starters: Bob Veale vs Steve Carlton | Sixth | 9 out |
| Tuesday, June 15 |
| » Lost to Pirates (30-28), 10-6 | Sportsman's Park III (17-16) | 28-31 | |
| » Starters: Don Cardwell vs Ray Sadecki | Sixth | 9 out |
| Wednesday, June 16 |
| » Lost to Pirates (31-28), 10-9 | Sportsman's Park III (17-17) | 28-32 | Lost 2 |
| » Starters: Bob Friend vs Ray Washburn | Seventh | 10 out |
| Thursday, June 17 |
| » Lost to Pirates (32-28), 4-1 | Sportsman's Park III (17-18) | 28-33 | Lost 3 |
| » Starters: Vern Law vs Bob Gibson | Sixth | 11 out |
| Friday, June 18 |
| » Defeated Braves (33-24), 5-4 | County Stadium (2-2) | 29-33 | |
| » Starters: Curt Simmons vs Wade Blasingame | Seventh | 10 out |
| » Major-league debuts: Don Dennis (Cardinals) |
| Saturday, June 19 |
| » Lost to Braves (34-24), 6-5 | County Stadium (2-3) | 29-34 | |
| » Starters: Ray Sadecki vs Tony Cloninger | Seventh | 11 out |
| Sunday, June 20 |
| » Defeated Braves (34-25), 6-4 | County Stadium (3-3) | 30-34 | |
| » Starters: Bob Purkey vs Denny Lemaster | Seventh | 10½ out |
| Tuesday, June 22 |
| » Lost to Reds (37-27), 5-4 | Crosley Field (1-2) | 30-35 | |
| » Starters: Bob Gibson vs Joey Jay | Seventh | 11½ out |
| » Lost to Reds (38-27), 4-2 | Crosley Field (1-3) | 30-36 | Lost 2 |
| » Starters: Ray Washburn vs John Tsitouris | Seventh | 11½ out |
| Wednesday, June 23 |
| » Lost to Reds (39-27), 6-2 | Crosley Field (1-4) | 30-37 | Lost 3 |
| » Starters: Curt Simmons vs Jim Maloney | Seventh | 12 out |
| Thursday, June 24 |
| » Defeated Reds (39-28), 11-4 | Crosley Field (2-4) | 31-37 | |
| » Starters: Tracy Stallard vs Jim O'Toole | Seventh | 11 out |
| Friday, June 25 |
| » Lost to Cubs (31-37), 12-4 | Sportsman's Park III (17-19) | 31-38 | |
| » Starters: Bob Buhl vs Bob Purkey | Eighth | 12 out |
| Saturday, June 26 |
| » Defeated Cubs (31-38), 8-1 | Sportsman's Park III (18-19) | 32-38 | |
| » Starters: Cal Koonce vs Steve Carlton | Seventh | 11 out |
| Sunday, June 27 |
| » Defeated Cubs (31-39), 8-0 | Sportsman's Park III (19-19) | 33-38 | Won 2 |
| » Starters: Ernie Broglio vs Bob Gibson | Seventh | 10½ out |
| » Lost to Cubs (32-39), 6-3 | Sportsman's Park III (19-20) | 33-39 | |
| » Starters: Bob Hendley vs Curt Simmons | Seventh | 10½ out |
| Monday, June 28 |
| » Lost to Phillies (36-34), 3-0 | Shibe Park (1-4) | 33-40 | Lost 2 |
| » Starters: Tracy Stallard vs Chris Short | Eighth | 10½ out |
| Tuesday, June 29 |
| » Lost to Phillies (37-34), 7-1 | Shibe Park (1-5) | 33-41 | Lost 3 |
| » Starters: Bob Purkey vs Bo Belinsky | Eighth | 11½ out |
| Wednesday, June 30 |
| » Defeated Pirates (39-35), 7-1 | Forbes Field (5-0) | 34-41 | |
| » Starters: Ray Washburn vs Vern Law | Eighth | 11 out |
| Thursday, July 1 |
| » Defeated Pirates (39-36), 7-6 | Forbes Field (6-0) | 35-41 | Won 2 |
| » Starters: Curt Simmons vs Bob Veale | Eighth | 10 out |
| Friday, July 2 |
| » Defeated Mets (27-51), 6-3 | Shea Stadium (2-1) | 36-41 | Won 3 |
| » Starters: Bob Gibson vs Frank Lary | Seventh | 9 out |
| Saturday, July 3 |
| » Defeated Mets (27-52), 2-0 | Shea Stadium (3-1) | 37-41 | Won 4 |
| » Starters: Tracy Stallard vs Jack Fisher | Seventh | 9 out |
| Sunday, July 4 |
| » Defeated Mets (27-53), 6-2 | Shea Stadium (4-1) | 38-41 | Won 5 |
| » Starters: Bob Purkey vs Galen Cisco | Seventh | 8 out |
| Monday, July 5 |
| » Defeated Giants (42-35), 3-2 | Sportsman's Park III (20-20) | 39-41 | Won 6 |
| » Starters: Gaylord Perry vs Ray Washburn | Seventh | 7 out |
| Tuesday, July 6 |
| » Defeated Giants (42-36), 3-2 | Sportsman's Park III (21-20) | 40-41 | Won 7 |
| » Starters: Juan Marichal vs Curt Simmons | Seventh | 7 out |
| Former Cardinal Jimmy Ring dies in New York, NY at the age of 71. |
| Wednesday, July 7 |
| » Lost to Giants (43-36), 4-2 | Sportsman's Park III (21-21) | 40-42 | |
| » Starters: Bob Shaw vs Bob Gibson | Seventh | 7 out |
| Friday, July 9 |
| » Defeated Cubs (37-45), 7-3 | Wrigley Field (1-2) | 41-42 | |
| » Starters: Tracy Stallard vs Bob Buhl | Seventh | 7 out |
| Saturday, July 10 |
| » Lost to Cubs (38-45), 5-3 | Wrigley Field (1-3) | 41-43 | |
| » Starters: Ray Washburn vs Dick Ellsworth | Seventh | 8 out |
| Sunday, July 11 |
| » Lost to Cubs (39-45), 6-0 | Wrigley Field (1-4) | 41-44 | Lost 2 |
| » Starters: Curt Simmons vs Larry Jackson | Seventh | 8½ out |
| » Lost to Cubs (40-45), 6-0 | Wrigley Field (1-5) | 41-45 | Lost 3 |
| » Starters: Ray Sadecki vs Cal Koonce | Seventh | 8½ out |
| Thursday, July 15 |
| » Defeated Mets (29-57), 6-5 | Sportsman's Park III (22-21) | 42-45 | |
| » Starters: Jack Fisher vs Curt Simmons | Seventh | 8½ out |
| Future Cardinal Scott Livingstone is born in Dallas, TX. |
| Friday, July 16 |
| » Defeated Mets (29-58), 8-5 | Sportsman's Park III (23-21) | 43-45 | Won 2 |
| » Starters: Al Jackson vs Bob Gibson | Seventh | 8½ out |
| Saturday, July 17 |
| » Defeated Mets (29-59), 4-1 | Sportsman's Park III (24-21) | 44-45 | Won 3 |
| » Starters: Larry Miller vs Bob Purkey | Sixth | 8½ out |
| Sunday, July 18 |
| » Defeated Phillies (46-42), 3-1 | Sportsman's Park III (25-21) | 45-45 | Won 4 |
| » Starters: Bo Belinsky vs Tracy Stallard | Sixth | 8½ out |
| Monday, July 19 |
| » Lost to Phillies (47-42), 5-2 | Sportsman's Park III (25-22) | 45-46 | |
| » Starters: Chris Short vs Ray Washburn | Sixth | 9½ out |
| Tuesday, July 20 |
| » Defeated Phillies (47-43), 4-3 | Sportsman's Park III (26-22) | 46-46 | |
| » Starters: Jim Bunning vs Curt Simmons | Sixth | 9½ out |
| Wednesday, July 21 |
| » Lost to Astros (41-49), 2-0 | Astrodome (0-4) | 46-47 | |
| » Starters: Bob Gibson vs Bob Bruce | Sixth | 9½ out |
| Thursday, July 22 |
| » Lost to Astros (42-49), 3-2 | Astrodome (0-5) | 46-48 | Lost 2 |
| » Starters: Bob Purkey vs Larry Dierker | Seventh | 9½ out |
| Future Cardinal Gary Buckels is born in LaMirada, CA. |
| Friday, July 23 |
| » Defeated Dodgers (57-41), 4-3 | Dodger Stadium (3-1) | 47-48 | |
| » Starters: Tracy Stallard vs Don Drysdale | Seventh | 8½ out |
| Saturday, July 24 |
| » Defeated Dodgers (57-42), 3-2 | Dodger Stadium (4-1) | 48-48 | Won 2 |
| » Starters: Ray Sadecki vs Sandy Koufax | Seventh | 7½ out |
| Sunday, July 25 |
| » Lost to Dodgers (58-42), 5-1 | Dodger Stadium (4-2) | 48-49 | |
| » Starters: Curt Simmons vs Claude Osteen | Seventh | 8½ out |
| Monday, July 26 |
| » Defeated Giants (52-42), 7-4 | Candlestick Park (2-2) | 49-49 | |
| » Starters: Bob Gibson vs Juan Marichal | Seventh | 8½ out |
| Tuesday, July 27 |
| » Defeated Giants (52-43), 3-0 | Candlestick Park (3-2) | 50-49 | Won 2 |
| » Starters: Bob Purkey vs Warren Spahn | Seventh | 8½ out |
| Wednesday, July 28 |
| » Lost to Giants (53-43), 8-5 | Candlestick Park (3-3) | 50-50 | |
| » Starters: Tracy Stallard vs Ron Herbel | Sixth | 8½ out |
| Thursday, July 29 |
| Future Cardinal Luis Alicea is born in Santurce, P.R. |
| Friday, July 30 |
| » Lost to Dodgers (61-43), 4-2 | Sportsman's Park III (26-23) | 50-51 | Lost 2 |
| » Starters: Claude Osteen vs Curt Simmons | Seventh | 9½ out |
| Saturday, July 31 |
| » Defeated Dodgers (61-44), 4-3 | Sportsman's Park III (27-23) | 51-51 | |
| » Starters: Don Drysdale vs Bob Gibson | Sixth | 8½ out |
| Sunday, August 1 |
| » Lost to Dodgers (62-44), 3-2 | Sportsman's Park III (27-24) | 51-52 | |
| » Starters: Sandy Koufax vs Ray Sadecki | Seventh | 9½ out |
| Monday, August 2 |
| » Defeated Dodgers (62-45), 6-5 | Sportsman's Park III (28-24) | 52-52 | |
| » Starters: Johnny Podres vs Tracy Stallard | Seventh | 8½ out |
| Tuesday, August 3 |
| » Lost to Astros (45-58), 10-7 | Sportsman's Park III (28-25) | 52-53 | |
| » Starters: Larry Dierker vs Bob Purkey | Seventh | 8½ out |
| » Defeated Astros (45-59), 7-0 | Sportsman's Park III (29-25) | 53-53 | |
| » Starters: Turk Farrell vs Ray Washburn | Seventh | 8½ out |
| Wednesday, August 4 |
| » Defeated Astros (45-60), 9-4 | Sportsman's Park III (30-25) | 54-53 | Won 2 |
| » Starters: Don Nottebart vs Curt Simmons | Seventh | 8 out |
| Thursday, August 5 |
| » Defeated Astros (45-61), 3-1 | Sportsman's Park III (31-25) | 55-53 | Won 3 |
| » Starters: Bob Bruce vs Bob Gibson | Seventh | 8 out |
| Friday, August 6 |
| » Lost to Giants (59-46), 3-2 | Sportsman's Park III (31-26) | 55-54 | |
| » Starters: Gaylord Perry vs Ray Sadecki | Seventh | 8 out |
| Saturday, August 7 |
| » Lost to Giants (60-46), 10-4 | Sportsman's Park III (31-27) | 55-55 | Lost 2 |
| » Starters: Bob Shaw vs Tracy Stallard | Seventh | 9 out |
| Sunday, August 8 |
| » Lost to Giants (61-46), 6-4 | Sportsman's Park III (31-28) | 55-56 | Lost 3 |
| » Starters: Warren Spahn vs Curt Simmons | Seventh | 9 out |
| Tuesday, August 10 |
| » Lost to Braves (62-48), 5-3 | County Stadium (3-4) | 55-57 | Lost 4 |
| » Starters: Bob Gibson vs Tony Cloninger | Seventh | 10 out |
| Wednesday, August 11 |
| » Lost to Braves (63-48), 5-2 | County Stadium (3-5) | 55-58 | Lost 5 |
| » Starters: Ray Washburn vs Ken Johnson | Seventh | 11 out |
| Thursday, August 12 |
| » Defeated Braves (63-49), 5-4 | County Stadium (4-5) | 56-58 | |
| » Starters: Tracy Stallard vs Wade Blasingame | Seventh | 10½ out |
| Friday, August 13 |
| » Defeated Reds (63-51), 7-2 | Sportsman's Park III (32-28) | 57-58 | Won 2 |
| » Starters: Jim Maloney vs Curt Simmons | Seventh | 10½ out |
| Saturday, August 14 |
| » Lost to Reds (64-51), 4-2 | Sportsman's Park III (32-29) | 57-59 | |
| » Starters: Joe Nuxhall vs Ray Sadecki | Seventh | 11½ out |
| Sunday, August 15 |
| » Defeated Reds (64-52), 12-7 | Sportsman's Park III (33-29) | 58-59 | |
| » Starters: Sammy Ellis vs Bob Gibson | Seventh | 10½ out |
| Monday, August 16 |
| » Lost to Braves (67-49), 10-8 | Sportsman's Park III (33-30) | 58-60 | |
| » Starters: Wade Blasingame vs Bob Purkey | Seventh | 10½ out |
| Tuesday, August 17 |
| » Lost to Braves (68-49), 4-1 | Sportsman's Park III (33-31) | 58-61 | Lost 2 |
| » Starters: Denny Lemaster vs Tracy Stallard | Seventh | 11½ out |
| Wednesday, August 18 |
| » Lost to Braves (69-49), 5-3 | Sportsman's Park III (33-32) | 58-62 | Lost 3 |
| » Starters: Tony Cloninger vs Curt Simmons | Seventh | 12 out |
| Thursday, August 19 |
| » Defeated Braves (69-50), 5-4 | Sportsman's Park III (34-32) | 59-62 | |
| » Starters: Ken Johnson vs Ray Sadecki | Seventh | 11½ out |
| Friday, August 20 |
| » Defeated Mets (36-85), 8-1 | Shea Stadium (5-1) | 60-62 | Won 2 |
| » Starters: Bob Gibson vs Al Jackson | Seventh | 11 out |
| Saturday, August 21 |
| » Lost to Mets (37-85), 6-2 | Shea Stadium (5-2) | 60-63 | |
| » Starters: Bob Purkey vs Jack Fisher | Seventh | 11½ out |
| Sunday, August 22 |
| » Lost to Mets (38-85), 7-5 | Shea Stadium (5-3) | 60-64 | Lost 2 |
| » Starters: Tracy Stallard vs Darrell Sutherland | Seventh | 12 out |
| » Lost to Mets (39-85), 4-2 | Shea Stadium (5-4) | 60-65 | Lost 3 |
| » Starters: Ray Washburn vs Tug McGraw | Seventh | 12 out |
| Monday, August 23 |
| » Defeated Cubs (59-69), 10-2 | Sportsman's Park III (35-32) | 61-65 | |
| » Starters: Larry Jackson vs Curt Simmons | Seventh | 12 out |
| Tuesday, August 24 |
| » Defeated Cubs (59-70), 7-6 | Sportsman's Park III (36-32) | 62-65 | Won 2 |
| » Starters: Bill Faul vs Ray Sadecki | Seventh | 11 out |
| Wednesday, August 25 |
| » Lost to Cubs (60-70), 6-3 | Sportsman's Park III (36-33) | 62-66 | |
| » Starters: Dick Ellsworth vs Bob Gibson | Seventh | 11 out |
| Thursday, August 26 |
| » Defeated Cubs (60-71), 7-4 | Sportsman's Park III (37-33) | 63-66 | |
| » Starters: Billy Hoeft vs Bob Purkey | Sixth | 10 out |
| Friday, August 27 |
| » Defeated Reds (71-56), 6-5 | Crosley Field (3-4) | 64-66 | Won 2 |
| » Starters: Tracy Stallard vs Joey Jay | Sixth | 10 out |
| Saturday, August 28 |
| » Lost to Reds (72-56), 8-2 | Crosley Field (3-5) | 64-67 | |
| » Starters: Curt Simmons vs Jim Maloney | Seventh | 11 out |
| Sunday, August 29 |
| » Defeated Reds (72-57), 10-4 | Crosley Field (4-5) | 65-67 | |
| » Starters: Ray Sadecki vs Sammy Ellis | Seventh | 10 out |
| Tuesday, August 31 |
| » Defeated Cubs (63-72), 3-0 | Wrigley Field (2-5) | 66-67 | Won 2 |
| » Starters: Bob Gibson vs Dick Ellsworth | Sixth | 9½ out |
| Wednesday, September 1 |
| » Defeated Cubs (63-73), 9-0 | Wrigley Field (3-5) | 67-67 | Won 3 |
| » Starters: Tracy Stallard vs Larry Jackson | Seventh | 8 out |
| Thursday, September 2 |
| » Lost to Cubs (64-73), 5-3 | Wrigley Field (3-6) | 67-68 | |
| » Starters: Curt Simmons vs Bob Hendley | Seventh | 9 out |
| Friday, September 3 |
| » Lost to Mets (45-92), 6-3 | Sportsman's Park III (37-34) | 67-69 | Lost 2 |
| » Starters: Dick Selma vs Ray Sadecki | Seventh | 10 out |
| » Major-league debuts: Bobby Tolan (Cardinals) Greg Goossen (Mets) |
| Saturday, September 4 |
| » Major-league debuts: Ken Holtzman (Cubs) |
| Sunday, September 5 |
| » Defeated Mets (45-93), 3-0 | Sportsman's Park III (38-34) | 68-69 | |
| » Starters: Tug McGraw vs Bob Gibson | Seventh | 10 out |
| » Defeated Mets (45-94), 3-1 | Sportsman's Park III (39-34) | 69-69 | Won 2 |
| » Starters: Rob Gardner vs Ray Washburn | Seventh | 10 out |
| » Major-league debuts: George Kernek (Cardinals) |
| Monday, September 6 |
| » Defeated Phillies (69-68), 10-3 | Sportsman's Park III (40-34) | 70-69 | Won 3 |
| » Starters: Bo Belinsky vs Tracy Stallard | Sixth | 9½ out |
| » Lost to Phillies (70-68), 10-5 | Sportsman's Park III (40-35) | 70-70 | |
| » Starters: Chris Short vs Curt Simmons | Sixth | 9½ out |
| » Major-league debuts: Dennis Aust (Cardinals) |
| Wednesday, September 8 |
| » Lost to Pirates (77-66), 2-1 | Sportsman's Park III (40-36) | 70-71 | Lost 2 |
| » Starters: Bob Friend vs Ray Sadecki | Sixth | 10 out |
| Thursday, September 9 |
| » Major-league debuts: Byron Browne and Don Young (Cubs) |
| Future Cardinal Todd Zeile is born in Van Nuys, CA. |
| Friday, September 10 |
| » Lost to Phillies (72-68), 5-4 | Shibe Park (1-6) | 70-72 | Lost 3 |
| » Starters: Bob Gibson vs Jim Bunning | Seventh | 11½ out |
| » Major-league debuts: Ferguson Jenkins (Phillies) |
| Future Cardinal Tim Sherrill is born in Harrison, AR. |
| Saturday, September 11 |
| » Lost to Phillies (73-68), 3-1 | Shibe Park (1-7) | 70-73 | Lost 4 |
| » Starters: Tracy Stallard vs Chris Short | Seventh | 12½ out |
| Tuesday, September 14 |
| » Defeated Pirates (79-68), 3-2 | Forbes Field (7-0) | 71-73 | |
| » Starters: Bob Gibson vs Bob Friend | Sixth | 14 out |
| Wednesday, September 15 |
| » Defeated Pirates (79-69), 7-3 | Forbes Field (8-0) | 72-73 | Won 2 |
| » Starters: Ray Sadecki vs Bob Veale | Seventh | 14 out |
| » Major-league debuts: George Spriggs (Pirates) |
| Thursday, September 16 |
| » Defeated Pirates (79-70), 2-1 | Forbes Field (9-0) | 73-73 | Won 3 |
| » Starters: Tracy Stallard vs Tommie Sisk | Sixth | 14 out |
| Friday, September 17 |
| » Lost to Dodgers (84-64), 3-2 | Sportsman's Park III (40-37) | 73-74 | |
| » Starters: Don Drysdale vs Curt Simmons | Sixth | 14 out |
| » Major-league debuts: Larry Jaster (Cardinals) |
| Saturday, September 18 |
| » Lost to Dodgers (85-64), 1-0 | Sportsman's Park III (40-38) | 73-75 | Lost 2 |
| » Starters: Sandy Koufax vs Ray Washburn | Seventh | 15 out |
| Sunday, September 19 |
| » Lost to Dodgers (86-64), 5-0 | Sportsman's Park III (40-39) | 73-76 | Lost 3 |
| » Starters: Claude Osteen vs Bob Gibson | Seventh | |
