| Tuesday, January 5 |
| Former Athletic Frank Manush dies in Laguna Beach, CA at the age of 82. |
| Thursday, February 11 |
| Former Athletic Pete Noonan dies in Great Barrington, MA at the age of 84. |
| Wednesday, February 17 |
| Future Athletic Jim Bowie is born in Tokyo, Japan. |
| Tuesday, March 2 |
| Future Athletic Ron Gant is born in Victoria, TX. |
| Thursday, March 18 |
| Future Athletic Geronimo Berroa is born in Santo Domingo, D.R. |
| Monday, April 12 |
| » Lost to Tigers (1-0), 6-2 | Municipal Stadium (0-1) | 0-1 | |
| » Starters: Mickey Lolich vs Moe Drabowsky | Third | 1 out |
| Tuesday, April 13 |
| » Lost to Tigers (2-0), 11-4 | Municipal Stadium (0-2) | 0-2 | Lost 2 |
| » Starters: Hank Aguirre vs Diego Segui | Fourth | 2 out |
| Thursday, April 15 |
| » Defeated Indians (1-1), 7-3 | Municipal Stadium (1-2) | 1-2 | |
| » Starters: Sam McDowell vs John O'Donoghue | Fourth | 2 out |
| Saturday, April 17 |
| » Lost to Yankees (2-2), 5-2 | Municipal Stadium (1-3) | 1-3 | |
| » Starters: Al Downing vs Orlando Pena | Fifth | 2 out |
| Sunday, April 18 |
| » Lost to Yankees (3-2), 10-4 | Municipal Stadium (1-4) | 1-4 | Lost 2 |
| » Starters: Jim Bouton vs Moe Drabowsky | Seventh | 3 out |
| Monday, April 19 |
| » Defeated Yankees (3-3), 8-2 | Municipal Stadium (2-4) | 2-4 | |
| » Starters: Whitey Ford vs Diego Segui | Fifth | 2 out |
| Tuesday, April 20 |
| » Major-league debuts: Bob Schroder (Giants) |
| Wednesday, April 21 |
| » Lost to Tigers (5-2), 1-0 | Tiger Stadium (0-1) | 2-5 | |
| » Starters: John O'Donoghue vs Hank Aguirre | Ninth | 3 out |
| Friday, April 23 |
| » Lost to Indians (3-3), 6-2 | Cleveland Stadium (0-1) | 2-6 | Lost 2 |
| » Starters: Orlando Pena vs Dick Donovan | Tenth | 4½ out |
| Saturday, April 24 |
| » Lost to Indians (4-3), 4-1 | Cleveland Stadium (0-2) | 2-7 | Lost 3 |
| » Starters: Moe Drabowsky vs Ralph Terry | Tenth | 4½ out |
| Future Athletic Mike Blowers is born in Wurzburg, W.Germany. |
| Wednesday, April 28 |
| » Lost to Yankees (6-6), 5-1 | Yankee Stadium (0-1) | 2-8 | Lost 4 |
| » Starters: Diego Segui vs Al Downing | Ninth | 5½ out |
| Friday, April 30 |
| » Lost to Angels (6-7), 4-0 | Municipal Stadium (2-5) | 2-9 | Lost 5 |
| » Starters: Marcelino Lopez vs John O'Donoghue | Eighth | 6 out |
| Saturday, May 1 |
| » Lost to Angels (7-7), 3-1 | Municipal Stadium (2-6) | 2-10 | Lost 6 |
| » Starters: Rudy May vs Orlando Pena | Seventh | 6½ out |
| Sunday, May 2 |
| » Lost to Angels (8-7), 10-8 | Municipal Stadium (2-7) | 2-11 | Lost 7 |
| » Starters: Fred Newman vs Moe Drabowsky | Ninth | 6½ out |
| » Defeated Angels (8-8), 9-5 | Municipal Stadium (3-7) | 3-11 | |
| » Starters: Ken McBride vs Fred Talbot | Ninth | 6½ out |
| Future Athletic Felix Jose is born in Santo Domingo, D.R. |
| Monday, May 3 |
| » Defeated Senators (6-13), 5-3 | Municipal Stadium (4-7) | 4-11 | Won 2 |
| » Starters: Pete Richert vs Diego Segui | Tenth | 6 out |
| Tuesday, May 4 |
| » Lost to Senators (7-13), 4-2 | Municipal Stadium (4-8) | 4-12 | |
| » Starters: Phil Ortega vs John O'Donoghue | Tenth | 7 out |
| » Major-league debuts: Rene Lachemann (Athletics) |
| Thursday, May 6 |
| » Lost to Angels (12-8), 5-4 | Dodger Stadium (0-1) | 4-13 | Lost 2 |
| » Starters: Orlando Pena vs Rudy May | Tenth | 8½ out |
| Friday, May 7 |
| » Lost to Angels (13-8), 5-4 | Dodger Stadium (0-2) | 4-14 | Lost 3 |
| » Starters: Moe Drabowsky vs Dean Chance | Tenth | 9 out |
| » Defeated Angels (13-9), 6-3 | Dodger Stadium (1-2) | 5-14 | |
| » Starters: Fred Talbot vs Ron Piche | Tenth | 9 out |
| » Major-league debuts: Tom Harrison (Athletics) |
| Saturday, May 8 |
| » Lost to Angels (14-9), 3-2 | Dodger Stadium (1-3) | 5-15 | |
| » Starters: Diego Segui vs Marcelino Lopez | Tenth | 9 out |
| Sunday, May 9 |
| » Lost to Angels (15-9), 5-3 | Dodger Stadium (1-4) | 5-16 | Lost 2 |
| » Starters: John O'Donoghue vs Fred Newman | Tenth | 9 out |
| Wednesday, May 12 |
| » Lost to White Sox (15-8), 7-4 | Comiskey Park I (0-1) | 5-17 | Lost 3 |
| » Starters: Fred Talbot vs Juan Pizarro | Tenth | 11 out |
| » Lost to White Sox (16-8), 6-4 | Comiskey Park I (0-2) | 5-18 | Lost 4 |
| » Starters: Rollie Sheldon vs John Buzhardt | Tenth | 11 out |
| Thursday, May 13 |
| » Lost to White Sox (17-8), 6-3 | Comiskey Park I (0-3) | 5-19 | Lost 5 |
| » Starters: Diego Segui vs Gary Peters | Tenth | 11½ out |
| » Major-league debuts: Catfish Hunter (Athletics) |
| Friday, May 14 |
| » Lost to Twins (17-8), 5-3 | Municipal Stadium (4-9) | 5-20 | Lost 6 |
| » Starters: Jim Kaat vs John O'Donoghue | Tenth | 12½ out |
| Saturday, May 15 |
| » Lost to Twins (18-8), 2-0 | Municipal Stadium (4-10) | 5-21 | Lost 7 |
| » Starters: Dave Boswell vs Don Buschhorn | Tenth | 13½ out |
| » Major-league debuts: Don Buschhorn (Athletics) |
| Sunday, May 16 |
| » Defeated Twins (18-9), 7-4 | Municipal Stadium (5-10) | 6-21 | |
| » Manager: Haywood Sullivan |
| » Starters: Mudcat Grant vs Diego Segui | Ninth | 13½ out |
| » Defeated Twins (18-10), 4-2 | Municipal Stadium (6-10) | 7-21 | Won 2 |
| » Starters: Dick Stigman vs Fred Talbot | Ninth | 13½ out |
| Monday, May 17 |
| » Lost to White Sox (22-8), 13-2 | Municipal Stadium (6-11) | 7-22 | |
| » Starters: Gary Peters vs Rollie Sheldon | Tenth | 14½ out |
| Former Athletic Bill Bartley dies in Cincinnati, OH at the age of 81. |
| Tuesday, May 18 |
| » Lost to White Sox (23-8), 5-4 | Municipal Stadium (6-12) | 7-23 | Lost 2 |
| » Starters: Joe Horlen vs Orlando Pena | Tenth | 15½ out |
| Wednesday, May 19 |
| » Defeated White Sox (23-9), 7-3 | Municipal Stadium (7-12) | 8-23 | |
| » Starters: Bruce Howard vs John O'Donoghue | Tenth | 14½ out |
| Thursday, May 20 |
| Future Athletic Todd Stottlemyre is born in Sunnyside, WA. |
| Friday, May 21 |
| » Lost to Twins (21-12), 6-4 | Metropolitan Stadium (0-1) | 8-24 | |
| » Starters: Diego Segui vs Camilo Pascual | Tenth | 14½ out |
| Saturday, May 22 |
| » Defeated Twins (21-13), 6-2 | Metropolitan Stadium (1-1) | 9-24 | |
| » Starters: Fred Talbot vs Jim Kaat | Tenth | 13½ out |
| Tuesday, May 25 |
| » Lost to Orioles (22-17), 6-3 | Memorial Stadium (0-1) | 9-25 | |
| » Starters: John O'Donoghue vs Milt Pappas | Tenth | 13½ out |
| Wednesday, May 26 |
| » Defeated Orioles (22-18), 6-3 | Memorial Stadium (1-1) | 10-25 | |
| » Starters: Diego Segui vs Robin Roberts | Tenth | 12½ out |
| Friday, May 28 |
| » Lost to Red Sox (19-20), 9-3 | Fenway Park (0-1) | 10-26 | |
| » Starters: Fred Talbot vs Jim Lonborg | Tenth | 13½ out |
| Sunday, May 30 |
| » Lost to Red Sox (20-20), 3-2 | Fenway Park (0-2) | 10-27 | Lost 2 |
| » Starters: Rollie Sheldon vs Bill Monbouquette | Tenth | 14½ out |
| Monday, May 31 |
| » Lost to Senators (19-28), 5-2 | Robert F. Kennedy Stadium (0-1) | 10-28 | Lost 3 |
| » Starters: John O'Donoghue vs Howie Koplitz | Tenth | 15½ out |
| » Lost to Senators (20-28), 5-1 | Robert F. Kennedy Stadium (0-2) | 10-29 | Lost 4 |
| » Starters: Diego Segui vs Pete Richert | Tenth | 15½ out |
| Wednesday, June 2 |
| » Lost to Orioles (26-21), 6-4 | Municipal Stadium (7-13) | 10-30 | Lost 5 |
| » Starters: Steve Barber vs Fred Talbot | Tenth | 16½ out |
| Thursday, June 3 |
| » Major-league debuts: Bill Hands (Giants) |
| Saturday, June 5 |
| » Lost to Red Sox (22-24), 5-3 | Municipal Stadium (7-14) | 10-31 | Lost 6 |
| » Starters: Earl Wilson vs Diego Segui | Tenth | 18 out |
| » Major-league debuts: Jesse Hickman (Athletics) |
| Sunday, June 6 |
| » Lost to Red Sox (23-24), 9-4 | Municipal Stadium (7-15) | 10-32 | Lost 7 |
| » Starters: Dave Morehead vs Don Buschhorn | Tenth | 18½ out |
| » Defeated Red Sox (23-25), 4-3 | Municipal Stadium (8-15) | 11-32 | |
| » Starters: Dennis Bennett vs Rollie Sheldon | Tenth | 18½ out |
| Monday, June 7 |
| » Lost to Yankees (23-27), 4-2 | Municipal Stadium (8-16) | 11-33 | |
| » Starters: Jim Bouton vs Fred Talbot | Tenth | 18½ out |
| Tuesday, June 8 |
| » Defeated Yankees (23-28), 3-2 | Municipal Stadium (9-16) | 12-33 | |
| » Starters: Bill Stafford vs John O'Donoghue | Tenth | 18½ out |
| Wednesday, June 9 |
| » Lost to Yankees (24-28), 5-1 | Municipal Stadium (9-17) | 12-34 | |
| » Starters: Mel Stottlemyre vs Diego Segui | Tenth | 18½ out |
| Friday, June 11 |
| » Defeated Indians (27-22), 5-2 | Municipal Stadium (10-17) | 13-34 | |
| » Starters: Jack Kralick vs Rollie Sheldon | Tenth | 18½ out |
| Saturday, June 12 |
| » Defeated Indians (27-23), 7-0 | Municipal Stadium (11-17) | 14-34 | Won 2 |
| » Starters: Luis Tiant vs Fred Talbot | Tenth | 17½ out |
| Sunday, June 13 |
| » Defeated Indians (27-24), 8-4 | Municipal Stadium (12-17) | 15-34 | Won 3 |
| » Starters: Sonny Siebert vs Don Buschhorn | Tenth | 17 out |
| » Lost to Indians (28-24), 5-2 | Municipal Stadium (12-18) | 15-35 | |
| » Starters: Lee Stange vs John O'Donoghue | Tenth | 17 out |
| Tuesday, June 15 |
| » Defeated Angels (29-32), 5-0 | Municipal Stadium (13-18) | 16-35 | |
| » Starters: Marcelino Lopez vs Diego Segui | Tenth | 17 out |
| Wednesday, June 16 |
| » Lost to Angels (30-32), 7-1 | Municipal Stadium (13-19) | 16-36 | |
| » Starters: George Brunet vs Fred Talbot | Tenth | 17½ out |
| » Lost to Angels (31-32), 5-4 | Municipal Stadium (13-20) | 16-37 | Lost 2 |
| » Starters: Dean Chance vs Rollie Sheldon | Tenth | 17½ out |
| Thursday, June 17 |
| Future Athletic Mike Magnante is born in Glendale, CA. |
| Friday, June 18 |
| » Lost to Tigers (33-25), 3-1 | Tiger Stadium (0-2) | 16-38 | Lost 3 |
| » Starters: John O'Donoghue vs Hank Aguirre | Tenth | 18 out |
| Saturday, June 19 |
| » Lost to Tigers (34-25), 8-2 | Tiger Stadium (0-3) | 16-39 | Lost 4 |
| » Starters: Diego Segui vs Denny McLain | Tenth | 18 out |
| Sunday, June 20 |
| » Lost to Tigers (35-25), 12-8 | Tiger Stadium (0-4) | 16-40 | Lost 5 |
| » Starters: Catfish Hunter vs Mickey Lolich | Tenth | 19 out |
| » Defeated Tigers (35-26), 2-1 | Tiger Stadium (1-4) | 17-40 | |
| » Starters: Rollie Sheldon vs Dave Wickersham | Tenth | 19 out |
| Tuesday, June 22 |
| » Defeated Yankees (28-36), 6-2 | Yankee Stadium (1-1) | 18-40 | Won 2 |
| » Starters: John O'Donoghue vs Jim Bouton | Ninth | 18½ out |
| » Lost to Yankees (29-36), 4-2 | Yankee Stadium (1-2) | 18-41 | |
| » Starters: Fred Talbot vs Bill Stafford | Ninth | 18½ out |
| Wednesday, June 23 |
| » Lost to Yankees (30-36), 8-3 | Yankee Stadium (1-3) | 18-42 | Lost 2 |
| » Starters: Diego Segui vs Whitey Ford | Tenth | 19½ out |
| » Major-league debuts: Santiago Rosario (Athletics) |
| Thursday, June 24 |
| » Defeated Yankees (30-37), 6-2 | Yankee Stadium (2-3) | 19-42 | |
| » Starters: Rollie Sheldon vs Mel Stottlemyre | Ninth | 18½ out |
| Friday, June 25 |
| » Lost to Indians (39-25), 2-0 | Cleveland Stadium (0-3) | 19-43 | |
| » Starters: Catfish Hunter vs Sam McDowell | Ninth | 19½ out |
| Saturday, June 26 |
| » Defeated Indians (39-26), 4-2 | Cleveland Stadium (1-3) | 20-43 | |
| » Starters: Fred Talbot vs Lee Stange | Ninth | 18½ out |
| Sunday, June 27 |
| » Lost to Indians (40-26), 10-7 | Cleveland Stadium (1-4) | 20-44 | |
| » Starters: John O'Donoghue vs Luis Tiant | Ninth | 20½ out |
| » Lost to Indians (41-26), 11-7 | Cleveland Stadium (1-5) | 20-45 | Lost 2 |
| » Starters: Wes Stock vs Floyd Weaver | Ninth | 20½ out |
| Wednesday, June 30 |
| » Defeated White Sox (42-28), 2-1 | Municipal Stadium (14-20) | 21-45 | |
| » Starters: Gary Peters vs Fred Talbot | Tenth | 19½ out |
| » Defeated White Sox (42-29), 4-3 | Municipal Stadium (15-20) | 22-45 | Won 2 |
| » Starters: Bruce Howard vs Rollie Sheldon | Tenth | 19½ out |
| Friday, July 2 |
| » Lost to Twins (44-28), 3-1 | Municipal Stadium (15-21) | 22-46 | |
| » Starters: Mudcat Grant vs John O'Donoghue | Tenth | 21 out |
| Future Athletic Steve Sparks is born in Tulsa, OK. |
| Saturday, July 3 |
| » Lost to Twins (45-28), 3-2 | Municipal Stadium (15-22) | 22-47 | Lost 2 |
| » Starters: Jim Kaat vs Diego Segui | Ninth | 21 out |
| Sunday, July 4 |
| » Lost to Twins (46-28), 5-2 | Municipal Stadium (15-23) | 22-48 | Lost 3 |
| » Starters: Camilo Pascual vs Fred Talbot | Ninth | 22 out |
| Monday, July 5 |
| » Lost to Orioles (44-34), 7-4 | Municipal Stadium (15-24) | 22-49 | Lost 4 |
| » Starters: Dave McNally vs Rollie Sheldon | Tenth | 23½ out |
| Tuesday, July 6 |
| » Lost to Orioles (45-34), 4-1 | Municipal Stadium (15-25) | 22-50 | Lost 5 |
| » Starters: Steve Barber vs Catfish Hunter | Tenth | 24½ out |
| Wednesday, July 7 |
| » Lost to Orioles (46-34), 1-0 | Municipal Stadium (15-26) | 22-51 | Lost 6 |
| » Starters: John Miller vs John O'Donoghue | Tenth | 25½ out |
| Thursday, July 8 |
| » Lost to Orioles (47-34), 10-6 | Municipal Stadium (15-27) | 22-52 | Lost 7 |
| » Starters: Wally Bunker vs Diego Segui | Tenth | 26 out |
| Friday, July 9 |
| » Lost to Tigers (45-35), 7-5 | Municipal Stadium (15-28) | 22-53 | Lost 8 |
| » Starters: Joe Sparma vs Fred Talbot | Tenth | 27 out |
| Saturday, July 10 |
| » Defeated Tigers (45-36), 4-3 | Municipal Stadium (16-28) | 23-53 | |
| » Starters: Denny McLain vs Rollie Sheldon | Tenth | 26½ out |
| Future Athletic Buddy Groom is born in Dallas, TX. |
| Sunday, July 11 |
| » Lost to Tigers (46-36), 4-2 | Municipal Stadium (16-29) | 23-54 | |
| » Starters: Hank Aguirre vs Wes Stock | Tenth | 27½ out |
| Thursday, July 15 |
| » Lost to Twins (54-29), 11-3 | Metropolitan Stadium (1-2) | 23-55 | Lost 2 |
| » Starters: Fred Talbot vs Jim Kaat | Tenth | 27½ out |
| » Defeated Twins (54-30), 3-2 | Metropolitan Stadium (2-2) | 24-55 | |
| » Starters: Rollie Sheldon vs Jim Perry | Tenth | 27½ out |
| Friday, July 16 |
| » Defeated Twins (54-31), 10-2 | Metropolitan Stadium (3-2) | 25-55 | Won 2 |
| » Starters: Diego Segui vs Mudcat Grant | Tenth | 26½ out |
| Saturday, July 17 |
| » Defeated Twins (54-32), 5-4 | Metropolitan Stadium (4-2) | 26-55 | Won 3 |
| » Starters: John O'Donoghue vs Dick Stigman | Tenth | 25½ out |
| Sunday, July 18 |
| » Lost to White Sox (51-35), 3-2 | Comiskey Park I (0-4) | 26-56 | |
| » Starters: Catfish Hunter vs John Buzhardt | Eighth | 25½ out |
| » Defeated White Sox (51-36), 7-5 | Comiskey Park I (1-4) | 27-56 | |
| » Starters: Fred Talbot vs Gary Peters | Eighth | 25½ out |
| Monday, July 19 |
| » Defeated White Sox (51-37), 6-3 | Comiskey Park I (2-4) | 28-56 | Won 2 |
| » Starters: Rollie Sheldon vs Joe Horlen | Ninth | 25½ out |
| Wednesday, July 21 |
| » Lost to Orioles (53-37), 1-0 | Memorial Stadium (1-2) | 28-57 | |
| » Starters: John O'Donoghue vs Milt Pappas | Tenth | 27 out |
| » Lost to Orioles (54-37), 9-2 | Memorial Stadium (1-3) | 28-58 | Lost 2 |
| » Starters: Diego Segui vs John Miller | Tenth | 27 out |
| Future Athletic Mike Bordick is born in Marquette, MI. |
| Thursday, July 22 |
| » Defeated Orioles (54-38), 9-2 | Memorial Stadium (2-3) | 29-58 | |
| » Starters: Fred Talbot vs Wally Bunker | Tenth | 27 out |
| Friday, July 23 |
| » Lost to Senators (40-55), 5-3 | Robert F. Kennedy Stadium (0-3) | 29-59 | |
| » Starters: Catfish Hunter vs Mike McCormick | Tenth | 27 out |
| Saturday, July 24 |
| » Lost to Senators (41-55), 9-2 | Robert F. Kennedy Stadium (0-4) | 29-60 | Lost 2 |
| » Starters: Rollie Sheldon vs Phil Ortega | Tenth | 27 out |
| Sunday, July 25 |
| » Lost to Senators (42-55), 4-3 | Robert F. Kennedy Stadium (0-5) | 29-61 | Lost 3 |
| » Starters: Diego Segui vs Howie Koplitz | Tenth | 27½ out |
| » Defeated Senators (42-56), 5-3 | Robert F. Kennedy Stadium (1-5) | 30-61 | |
| » Starters: John O'Donoghue vs Buster Narum | Tenth | 27½ out |
| Future Athletic Torey Lovullo is born in Santa Monica, CA. |
| Tuesday, July 27 |
| » Defeated Red Sox (35-61), 7-3 | Fenway Park (1-2) | 31-61 | Won 2 |
| » Starters: Fred Talbot vs Jerry Stephenson | Tenth | 27 out |
| » Defeated Red Sox (35-62), 10-8 | Fenway Park (2-2) | 32-61 | Won 3 |
| » Starters: Catfish Hunter vs Jim Lonborg | Tenth | 27 out |
| Wednesday, July 28 |
| » Lost to Red Sox (36-62), 6-0 | Fenway Park (2-3) | 32-62 | |
| » Starters: Rollie Sheldon vs Bill Monbouquette | Tenth | 28 out |
| Thursday, July 29 |
| » Lost to Red Sox (37-62), 6-4 | Fenway Park (2-4) | 32-63 | Lost 2 |
| » Starters: Diego Segui vs Earl Wilson | Tenth | 28½ out |
| Friday, July 30 |
| » Lost to Senators (44-58), 3-1 | Municipal Stadium (16-30) | 32-64 | Lost 3 |
| » Starters: Mike McCormick vs John O'Donoghue | Ninth | 29½ out |
| Saturday, July 31 |
| » Defeated Senators (44-59), 5-4 | Municipal Stadium (17-30) | 33-64 | |
| » Starters: Buster Narum vs Fred Talbot | Ninth | 29½ out |
| Sunday, August 1 |
| » Lost to Senators (45-59), 3-2 | Municipal Stadium (17-31) | 33-65 | |
| » Starters: Pete Richert vs Rollie Sheldon | Tenth | 29 out |
| » Defeated Senators (45-60), 3-2 | Municipal Stadium (18-31) | 34-65 | |
| » Starters: Phil Ortega vs Catfish Hunter | Tenth | 29 out |
| Tuesday, August 3 |
| » Lost to Red Sox (39-64), 10-5 | Municipal Stadium (18-32) | 34-66 | |
| » Starters: Earl Wilson vs Diego Segui | Tenth | 30 out |
| Wednesday, August 4 |
| » Lost to Red Sox (40-64), 5-1 | Municipal Stadium (18-33) | 34-67 | Lost 2 |
| » Starters: Dave Morehead vs John O'Donoghue | Tenth | 31 out |
| Thursday, August 5 |
| » Defeated Red Sox (40-65), 5-1 | Municipal Stadium (19-33) | 35-67 | |
| » Starters: Jim Lonborg vs Fred Talbot | Tenth | 31 out |
| Friday, August 6 |
| » Defeated Orioles (62-44), 9-4 | Municipal Stadium (20-33) | 36-67 | Won 2 |
| » Starters: Milt Pappas vs Rollie Sheldon | Tenth | 31 out |
| Saturday, August 7 |
| » Defeated Orioles (62-45), 7-4 | Municipal Stadium (21-33) | 37-67 | Won 3 |
| » Starters: Steve Barber vs Catfish Hunter | Ninth | 31 out |
| » Major-league debuts: Mark Belanger (Orioles) |
| Sunday, August 8 |
| » Lost to Orioles (63-45), 9-5 | Municipal Stadium (21-34) | 37-68 | |
| » Starters: Wally Bunker vs Diego Segui | Ninth | 31½ out |
| » Defeated Orioles (63-46), 4-3 | Municipal Stadium (22-34) | 38-68 | |
| » Starters: Dave McNally vs John O'Donoghue | Ninth | 31½ out |
| Tuesday, August 10 |
| » Lost to Tigers (60-49), 3-0 | Tiger Stadium (1-5) | 38-69 | |
| » Starters: Fred Talbot vs Dave Wickersham | Ninth | 32½ out |
| Wednesday, August 11 |
| » Lost to Tigers (61-49), 6-2 | Tiger Stadium (1-6) | 38-70 | Lost 2 |
| » Starters: Catfish Hunter vs Joe Sparma | Tenth | 33 out |
| » Lost to Tigers (62-49), 5-4 | Tiger Stadium (1-7) | 38-71 | Lost 3 |
| » Starters: Rollie Sheldon vs Mickey Lolich | Tenth | 33 out |
| Thursday, August 12 |
| » Lost to Tigers (63-49), 11-1 | Tiger Stadium (1-8) | 38-72 | Lost 4 |
| » Starters: Diego Segui vs Hank Aguirre | Ninth | 34 out |
| Friday, August 13 |
| » Lost to Yankees (58-59), 3-1 | Yankee Stadium (2-4) | 38-73 | Lost 5 |
| » Starters: John O'Donoghue vs Jack Cullen | Ninth | 34 out |
| Saturday, August 14 |
| » Lost to Yankees (59-59), 3-2 | Yankee Stadium (2-5) | 38-74 | Lost 6 |
| » Starters: Fred Talbot vs Whitey Ford | Tenth | 34 out |
| Sunday, August 15 |
| » Defeated Yankees (59-60), 4-1 | Yankee Stadium (3-5) | 39-74 | |
| » Starters: Catfish Hunter vs Mel Stottlemyre | Ninth | 34 out |
| » Lost to Yankees (60-60), 7-3 | Yankee Stadium (3-6) | 39-75 | |
| » Starters: Rollie Sheldon vs Bill Stafford | Ninth | 34 out |
| Tuesday, August 17 |
| » Defeated Indians (66-51), 3-2 | Cleveland Stadium (2-5) | 40-75 | |
| » Starters: Lew Krausse vs Lee Stange | Eighth | 33 out |
| Wednesday, August 18 |
| » Defeated Indians (66-52), 4-2 | Cleveland Stadium (3-5) | 41-75 | Won 2 |
| » Starters: John O'Donoghue vs Sam McDowell | Ninth | 33 out |
| » Lost to Indians (67-52), 4-1 | Cleveland Stadium (3-6) | 41-76 | |
| » Starters: Fred Talbot vs Jack Kralick | Ninth | 33 out |
| Friday, August 20 |
| » Lost to White Sox (68-51), 3-1 | Municipal Stadium (22-35) | 41-77 | Lost 2 |
| » Starters: Gary Peters vs Catfish Hunter | Ninth | 34½ out |
| Saturday, August 21 |
| » Lost to White Sox (69-51), 7-6 | Municipal Stadium (22-36) | 41-78 | Lost 3 |
| » Starters: Tommy John vs Rollie Sheldon | Tenth | 35½ out |
| Sunday, August 22 |
| » Lost to White Sox (70-51), 8-3 | Municipal Stadium (22-37) | 41-79 | Lost 4 |
| » Starters: Joe Horlen vs Fred Talbot | Tenth | 36 out |
| » Lost to White Sox (71-51), 2-1 | Municipal Stadium (22-38) | 41-80 | Lost 5 |
| » Starters: John Buzhardt vs John O'Donoghue | Tenth | 36 out |
| Monday, August 23 |
| » Defeated Tigers (70-54), 4-3 | Municipal Stadium (23-38) | 42-80 | |
| » Starters: Mickey Lolich vs Rollie Sheldon | Tenth | 36 out |
| Tuesday, August 24 |
| » Lost to Tigers (71-54), 8-2 | Municipal Stadium (23-39) | 42-81 | |
| » Starters: Denny McLain vs Lew Krausse | Tenth | 36 out |
| Future Athletic Webster Garrison is born in Marrero, LA. |
| Wednesday, August 25 |
| » Defeated Tigers (71-55), 5-0 | Municipal Stadium (24-39) | 43-81 | |
| » Starters: Joe Sparma vs Catfish Hunter | Tenth | 36 out |
| Thursday, August 26 |
| » Defeated Tigers (71-56), 5-3 | Municipal Stadium (25-39) | 44-81 | Won 2 |
| » Starters: Hank Aguirre vs Fred Talbot | Tenth | 36 out |
| Friday, August 27 |
| » Defeated Yankees (64-65), 1-0 | Municipal Stadium (26-39) | 45-81 | Won 3 |
| » Starters: Whitey Ford vs John O'Donoghue | Tenth | 36 out |
| Saturday, August 28 |
| » Defeated Yankees (64-66), 4-0 | Municipal Stadium (27-39) | 46-81 | Won 4 |
| » Starters: Mel Stottlemyre vs Rollie Sheldon | Tenth | 35 out |
| Sunday, August 29 |
| » Lost to Yankees (65-66), 4-3 | Municipal Stadium (27-40) | 46-82 | |
| » Starters: Al Downing vs Lew Krausse | Tenth | 35 out |
| Tuesday, August 31 |
| » Lost to Indians (73-57), 8-1 | Municipal Stadium (27-41) | 46-83 | Lost 2 |
| » Starters: Sam McDowell vs Catfish Hunter | Tenth | 35 out |
| » Defeated Indians (73-58), 3-2 | Municipal Stadium (28-41) | 47-83 | |
| » Starters: Sonny Siebert vs Fred Talbot | Tenth | 35 out |
| Wednesday, September 1 |
| » Defeated Indians (73-59), 4-3 | Municipal Stadium (29-41) | 48-83 | Won 2 |
| » Starters: Luis Tiant vs John O'Donoghue | Tenth | 35 out |
| » Major-league debuts: Richie Scheinblum (Indians) |
| Thursday, September 2 |
| » Lost to Indians (74-59), 10-6 | Municipal Stadium (29-42) | 48-84 | |
| » Starters: Ralph Terry vs Rollie Sheldon | Tenth | 35 out |
| Friday, September 3 |
| » Defeated Angels (62-74), 4-1 | Dodger Stadium (2-4) | 49-84 | |
| » Starters: Dick Joyce vs George Brunet | Ninth | 34½ out |
| » Defeated Angels (62-75), 1-0 | Dodger Stadium (3-4) | 50-84 | Won 2 |
| » Starters: Lew Krausse vs Fred Newman | Ninth | 34½ out |
| » Major-league debuts: Dick Joyce (Athletics) |
| Saturday, September 4 |
| » Lost to Angels (63-75), 4-1 | Dodger Stadium (3-5) | 50-85 | |
| » Starters: Catfish Hunter vs Dean Chance | Tenth | 34½ out |
| Sunday, September 5 |
| » Lost to Angels (64-75), 4-3 | Dodger Stadium (3-6) | 50-86 | Lost 2 |
| » Starters: Fred Talbot vs Rudy May | Tenth | 34½ out |
| Monday, September 6 |
| » Lost to Twins (87-53), 8-6 | Municipal Stadium (29-43) | 50-87 | Lost 3 |
| » Starters: Camilo Pascual vs John O'Donoghue | Tenth | 34½ out |
| » Defeated Twins (87-54), 4-3 | Municipal Stadium (30-43) | 51-87 | |
| » Starters: Jim Merritt vs Rollie Sheldon | Tenth | 34½ out |
| Wednesday, September 8 |
| » Lost to Angels (65-77), 5-3 | Municipal Stadium (30-44) | 51-88 | |
| » Starters: Dean Chance vs Dick Joyce | Tenth | 35½ out |
| » Major-league debuts: Randy Schwartz (Athletics) |
| Thursday, September 9 |
| » Lost to Angels (66-77), 7-2 | Municipal Stadium (30-45) | 51-89 | Lost 2 |
| » Starters: Fred Newman vs Lew Krausse | Tenth | 36½ out |
| » Major-league debuts: Ron Tompkins (Athletics) |
| Friday, September 10 |
| » Lost to Orioles (81-60), 5-2 | Memorial Stadium (2-4) | 51-90 | Lost 3 |
| » Starters: Fred Talbot vs Milt Pappas | Tenth | 37 out |
| » Defeated Orioles (81-61), 10-5 | Memorial Stadium (3-4) | 52-90 | |
| » Starters: Catfish Hunter vs John Miller | Tenth | 37 out |
| Saturday, September 11 |
| » Defeated Orioles (81-62), 3-2 | Memorial Stadium (4-4) | 53-90 | Won 2 |
| » Starters: Rollie Sheldon vs Wally Bunker | Tenth | 37 out |
| Tuesday, September 14 |
| » Lost to Twins (93-54), 4-3 | Metropolitan Stadium (4-3) | 53-91 | |
| » Starters: John O'Donoghue vs Jim Kaat | Tenth | 38½ out |
| Future Athletic Troy Neel is born in Freeport, TX. |
| Wednesday, September 15 |
| » Lost to Twins (94-54), 7-5 | Metropolitan Stadium (4-4) | 53-92 | Lost 2 |
| » Starters: Catfish Hunter vs Jim Perry | Tenth | 39½ out |
| Thursday, September 16 |
| » Major-league debuts: Jim Ray (Astros) |
| Friday, September 17 |
| » Defeated Red Sox (58-92), 8-7 | Fenway Park (3-4) | 54-92 | |
| » Starters: Rollie Sheldon vs Jim Lonborg | Tenth | 38½ out |
| Saturday, September 18 |
| » Lost to Red Sox (59-92), 5-3 | Fenway Park (3-5) | 54-93 | |
| » Starters: Dick Joyce vs Earl Wilson | Tenth | 39½ out |
| Sunday, September 19 |
| » Lost to Red Sox (60-92), 3-2 | Fenway Park (3-6) | 54-94 | Lost 2 |
| » Starters: Fred Talbot vs Bill Monbouquette | Tenth | 40½ out |
| Monday, September 20 |
| » Defeated Twins (96-56), 8-2 | Metropolitan Stadium (5-4) | 55-94 | |
| » Starters: Catfish Hunter vs Mudcat Grant | Tenth | 39½ out |
| Tuesday, September 21 |
| » Lost to Senators (66-85), 4-3 | Municipal Stadium (30-46) | 55-95 | |
| » Starters: Jim Duckworth vs Rollie Sheldon | Tenth | 39½ out |
| Wednesday, September 22 |
| » Lost to Senators (67-85), 8-2 | Municipal Stadium (30-47) | 55-96 | Lost 2 |
| » Starters: Pete Richert vs Ron Tompkins | Tenth | 39½ out |
| Future Athletic Mark Guthrie is born in Buffalo, NY. |
| Thursday, September 23 |
| » Defeated Senators (67-86), 8-7 | Municipal Stadium (31-47) | 56-96 | |
| » Starters: Mike McCormick vs Fred Talbot | Tenth | 39 out |
| Friday, September 24 |
| » Defeated Red Sox (60-96), 8-0 | Municipal Stadium (32-47) | 57-96 | Won 2 |
| » Starters: Earl Wilson vs Catfish Hunter | Tenth | 38½ out |
| Saturday, September 25 |
| » Lost to Red Sox (61-96), 5-2 | Municipal Stadium (32-48) | 57-97 | |
| » Starters: Bill Monbouquette vs Satchel Paige | Tenth | 40 out |
| Sunday, September 26 |
| » Defeated Red Sox (61-97), 2-1 | Municipal Stadium (33-48) | 58-97 | |
| » Starters: Dennis Bennett vs Rollie Sheldon | Tenth | 40 out |
| Monday, September 27 |
| » Lost to Orioles (91-64), 6-4 | Memorial Stadi |
