| Saturday, January 2 |
| Future Astro Greg Swindell is born in Fort Worth, TX. |
| Wednesday, February 3 |
| Future Astro Rich Scheid is born in Staten Island, NY. |
| Monday, February 22 |
| Future Astro Eric Yelding is born in Montrose, AL. |
| Friday, March 12 |
| Future Astro Steve Finley is born in Paducah, KY. |
| Monday, April 12 |
| » Lost to Phillies (1-0), 2-0 | Astrodome (0-1) | 0-1 | |
| » Starters: Chris Short vs Bob Bruce | Third | 1 out |
| Wednesday, April 14 |
| » Defeated Mets (0-2), 7-6 | Shea Stadium (1-0) | 1-1 | |
| » Starters: Turk Farrell vs Warren Spahn | Third | 1 out |
| » Major-league debuts: Danny Napoleon (Mets) |
| Thursday, April 15 |
| » Lost to Mets (1-2), 5-4 | Shea Stadium (1-1) | 1-2 | |
| » Starters: Ken Johnson vs Jack Fisher | Fourth | 1½ out |
| Saturday, April 17 |
| » Lost to Pirates (3-1), 3-2 | Forbes Field (0-1) | 1-3 | Lost 2 |
| » Starters: Don Nottebart vs Bob Veale | Fourth | 2 out |
| Sunday, April 18 |
| » Defeated Pirates (3-2), 3-1 | Forbes Field (1-1) | 2-3 | |
| » Starters: Bob Bruce vs Vern Law | Sixth | 2 out |
| » Lost to Pirates (4-2), 5-4 | Forbes Field (1-2) | 2-4 | |
| » Starters: Don Larsen vs Don Cardwell | Sixth | 2 out |
| Monday, April 19 |
| » Lost to Phillies (3-2), 8-0 | Shibe Park (0-1) | 2-5 | Lost 2 |
| » Starters: Turk Farrell vs Jim Bunning | Sixth | 2½ out |
| Tuesday, April 20 |
| » Lost to Phillies (4-2), 2-1 | Shibe Park (0-2) | 2-6 | Lost 3 |
| » Starters: Ken Johnson vs Ray Herbert | Sixth | 3½ out |
| Wednesday, April 21 |
| » Defeated Phillies (4-3), 11-4 | Shibe Park (1-2) | 3-6 | |
| » Starters: Don Nottebart vs Chris Short | Eighth | 3 out |
| Friday, April 23 |
| » Defeated Pirates (5-4), 4-3 | Astrodome (1-1) | 4-6 | Won 2 |
| » Starters: Bob Veale vs Bob Bruce | Seventh | 3 out |
| Saturday, April 24 |
| » Defeated Pirates (5-5), 5-0 | Astrodome (2-1) | 5-6 | Won 3 |
| » Starters: Vern Law vs Turk Farrell | Fifth | 3 out |
| Sunday, April 25 |
| » Defeated Pirates (5-6), 5-4 | Astrodome (3-1) | 6-6 | Won 4 |
| » Starters: Don Cardwell vs Ken Johnson | Fifth | 2 out |
| Monday, April 26 |
| » Defeated Pirates (5-7), 2-0 | Astrodome (4-1) | 7-6 | Won 5 |
| » Starters: Bob Friend vs Dave Giusti | Fifth | 2 out |
| Tuesday, April 27 |
| » Defeated Mets (6-8), 3-2 | Astrodome (5-1) | 8-6 | Won 6 |
| » Starters: Jack Fisher vs Don Nottebart | Fourth | 1 out |
| Wednesday, April 28 |
| » Defeated Mets (6-9), 12-9 | Astrodome (6-1) | 9-6 | Won 7 |
| » Starters: Frank Lary vs Bob Bruce | Third | 1½ out |
| Friday, April 30 |
| » Defeated Cubs (7-6), 4-3 | Astrodome (7-1) | 10-6 | Won 8 |
| » Starters: Bob Buhl vs Turk Farrell | Third | ½ out |
| Saturday, May 1 |
| » Defeated Cubs (7-7), 6-4 | Astrodome (8-1) | 11-6 | Won 9 |
| » Starters: Lew Burdette vs Ken Johnson | Second | 1 out |
| » Defeated Cubs (7-8), 6-1 | Astrodome (9-1) | 12-6 | Won 10 |
| » Starters: Dick Ellsworth vs Dave Giusti | Second | 1 out |
| Sunday, May 2 |
| » Lost to Cubs (8-8), 6-3 | Astrodome (9-2) | 12-7 | |
| » Starters: Larry Jackson vs Don Nottebart | Third | 1 out |
| Tuesday, May 4 |
| » Lost to Braves (8-8), 9-3 | County Stadium (0-1) | 12-8 | Lost 2 |
| » Starters: Bob Bruce vs Tony Cloninger | Second | 1 out |
| Wednesday, May 5 |
| » Lost to Braves (9-8), 2-1 | County Stadium (0-2) | 12-9 | Lost 3 |
| » Starters: Turk Farrell vs Wade Blasingame | Third | 2 out |
| Friday, May 7 |
| » Defeated Cubs (10-10), 5-4 | Wrigley Field (1-0) | 13-9 | |
| » Starters: Dave Giusti vs Lew Burdette | Second | 2½ out |
| Saturday, May 8 |
| » Defeated Cubs (10-11), 11-6 | Wrigley Field (2-0) | 14-9 | Won 2 |
| » Starters: Don Nottebart vs Cal Koonce | Second | 2½ out |
| Sunday, May 9 |
| » Defeated Cubs (10-12), 11-5 | Wrigley Field (3-0) | 15-9 | Won 3 |
| » Starters: Ken Johnson vs Bob Buhl | Third | 2 out |
| » Lost to Cubs (11-12), 7-1 | Wrigley Field (3-1) | 15-10 | |
| » Starters: Bob Bruce vs Dick Ellsworth | Third | 2 out |
| Monday, May 10 |
| » Lost to Dodgers (17-7), 3-2 | Dodger Stadium (0-1) | 15-11 | Lost 2 |
| » Starters: Danny Coombs vs Johnny Podres | Third | 3 out |
| Tuesday, May 11 |
| » Defeated Dodgers (17-8), 2-1 | Dodger Stadium (1-1) | 16-11 | |
| » Starters: Dave Giusti vs Claude Osteen | Third | 2 out |
| Wednesday, May 12 |
| » Lost to Dodgers (18-8), 4-2 | Dodger Stadium (1-2) | 16-12 | |
| » Starters: Don Nottebart vs Don Drysdale | Third | 3 out |
| Thursday, May 13 |
| » Lost to Dodgers (19-8), 3-0 | Dodger Stadium (1-3) | 16-13 | Lost 2 |
| » Starters: Bob Bruce vs Sandy Koufax | Third | 4 out |
| Friday, May 14 |
| » Lost to Giants (14-14), 2-1 | Candlestick Park (0-1) | 16-14 | Lost 3 |
| » Starters: Ken Johnson vs Gaylord Perry | Third | 4 out |
| Saturday, May 15 |
| » Lost to Giants (15-14), 8-2 | Candlestick Park (0-2) | 16-15 | Lost 4 |
| » Starters: Larry Dierker vs Ron Herbel | Fifth | 5 out |
| Sunday, May 16 |
| » Lost to Giants (16-14), 10-5 | Candlestick Park (0-3) | 16-16 | Lost 5 |
| » Starters: Dave Giusti vs Juan Marichal | Sixth | 6 out |
| » Lost to Giants (17-14), 4-3 | Candlestick Park (0-4) | 16-17 | Lost 6 |
| » Starters: Don Nottebart vs Bob Shaw | Sixth | 6 out |
| Monday, May 17 |
| » Lost to Dodgers (22-10), 5-3 | Astrodome (9-3) | 16-18 | Lost 7 |
| » Starters: Sandy Koufax vs Bob Bruce | Seventh | 7 out |
| Tuesday, May 18 |
| » Defeated Dodgers (22-11), 4-1 | Astrodome (10-3) | 17-18 | |
| » Starters: Jim Brewer vs Ken Johnson | Sixth | 6 out |
| Wednesday, May 19 |
| » Lost to Dodgers (23-11), 4-2 | Astrodome (10-4) | 17-19 | |
| » Starters: Claude Osteen vs Dave Giusti | Seventh | 7 out |
| Friday, May 21 |
| » Lost to Giants (19-16), 8-1 | Astrodome (10-5) | 17-20 | Lost 2 |
| » Starters: Ron Herbel vs Don Nottebart | Eighth | 7 out |
| Saturday, May 22 |
| » Lost to Giants (20-16), 10-1 | Astrodome (10-6) | 17-21 | Lost 3 |
| » Starters: Juan Marichal vs Bob Bruce | Seventh | 7½ out |
| » Defeated Giants (20-17), 3-2 | Astrodome (11-6) | 18-21 | |
| » Starters: Jack Sanford vs Turk Farrell | Seventh | 7½ out |
| Sunday, May 23 |
| » Lost to Giants (21-17), 5-2 | Astrodome (11-7) | 18-22 | |
| » Starters: Gaylord Perry vs Ken Johnson | Eighth | 7½ out |
| Monday, May 24 |
| » Lost to Reds (22-14), 5-2 | Astrodome (11-8) | 18-23 | Lost 2 |
| » Starters: Jim Maloney vs Dave Giusti | Eighth | 7½ out |
| Tuesday, May 25 |
| » Lost to Reds (23-14), 7-4 | Astrodome (11-9) | 18-24 | Lost 3 |
| » Starters: Sammy Ellis vs Don Nottebart | Eighth | 8½ out |
| Wednesday, May 26 |
| » Defeated Reds (23-15), 8-3 | Astrodome (12-9) | 19-24 | |
| » Starters: Billy McCool vs Bob Bruce | Eighth | 7½ out |
| Thursday, May 27 |
| » Defeated Cardinals (23-17), 6-1 | Astrodome (13-9) | 20-24 | Won 2 |
| » Starters: Ray Washburn vs Turk Farrell | Seventh | 7½ out |
| Friday, May 28 |
| » Defeated Cardinals (23-18), 3-2 | Astrodome (14-9) | 21-24 | Won 3 |
| » Starters: Ray Sadecki vs Dave Giusti | Sixth | 6½ out |
| Saturday, May 29 |
| » Defeated Cardinals (23-19), 4-3 | Astrodome (15-9) | 22-24 | Won 4 |
| » Starters: Tracy Stallard vs Don Nottebart | Sixth | 6½ out |
| Sunday, May 30 |
| » Lost to Braves (21-18), 6-5 | Astrodome (15-10) | 22-25 | |
| » Starters: Wade Blasingame vs Larry Dierker | Sixth | 7½ out |
| Monday, May 31 |
| » Defeated Braves (21-19), 7-2 | Astrodome (16-10) | 23-25 | |
| » Starters: Tony Cloninger vs Bob Bruce | Sixth | 7 out |
| Tuesday, June 1 |
| » Lost to Braves (22-19), 2-1 | Astrodome (16-11) | 23-26 | |
| » Starters: Denny Lemaster vs Turk Farrell | Sixth | 7½ out |
| Wednesday, June 2 |
| » Lost to Reds (25-20), 5-2 | Crosley Field (0-1) | 23-27 | Lost 2 |
| » Starters: Dave Giusti vs Sammy Ellis | Seventh | 8½ out |
| Thursday, June 3 |
| » Defeated Reds (25-21), 8-3 | Crosley Field (1-1) | 24-27 | |
| » Starters: Don Nottebart vs Gerry Arrigo | Sixth | 8½ out |
| Friday, June 4 |
| » Defeated Cardinals (24-24), 5-2 | Sportsman's Park III (1-0) | 25-27 | Won 2 |
| » Starters: Bob Bruce vs Bob Gibson | Sixth | 7½ out |
| Saturday, June 5 |
| » Lost to Cardinals (25-24), 4-3 | Sportsman's Park III (1-1) | 25-28 | |
| » Starters: Larry Dierker vs Curt Simmons | Sixth | 7½ out |
| Sunday, June 6 |
| » Defeated Cardinals (25-25), 10-1 | Sportsman's Park III (2-1) | 26-28 | |
| » Starters: Claude Raymond vs Ray Sadecki | Sixth | 7 out |
| Tuesday, June 8 |
| » Lost to Pirates (25-26), 7-6 | Forbes Field (1-3) | 26-29 | |
| » Starters: Turk Farrell vs Bob Friend | Sixth | 8½ out |
| Wednesday, June 9 |
| » Lost to Pirates (26-26), 11-3 | Forbes Field (1-4) | 26-30 | Lost 2 |
| » Starters: Don Nottebart vs Vern Law | Sixth | 8½ out |
| Thursday, June 10 |
| » Lost to Pirates (27-26), 4-2 | Forbes Field (1-5) | 26-31 | Lost 3 |
| » Starters: Bob Bruce vs Bob Veale | Eighth | 8½ out |
| Friday, June 11 |
| » Lost to Phillies (26-28), 6-5 | Shibe Park (1-3) | 26-32 | Lost 4 |
| » Starters: Dave Giusti vs Ray Culp | Seventh | 9½ out |
| Saturday, June 12 |
| » Lost to Phillies (27-28), 5-4 | Shibe Park (1-4) | 26-33 | Lost 5 |
| » Starters: Turk Farrell vs Jim Bunning | Eighth | 10½ out |
| Sunday, June 13 |
| » Lost to Phillies (28-28), 5-0 | Shibe Park (1-5) | 26-34 | Lost 6 |
| » Starters: Claude Raymond vs Chris Short | Eighth | 12 out |
| Monday, June 14 |
| » Lost to Cubs (25-32), 2-0 | Astrodome (16-12) | 26-35 | Lost 7 |
| » Starters: Larry Jackson vs Bob Bruce | Eighth | 12½ out |
| Tuesday, June 15 |
| » Lost to Cubs (26-32), 5-0 | Astrodome (16-13) | 26-36 | Lost 8 |
| » Starters: Bob Buhl vs Larry Dierker | Eighth | 12½ out |
| Wednesday, June 16 |
| » Defeated Cubs (26-33), 3-2 | Astrodome (17-13) | 27-36 | |
| » Starters: Dick Ellsworth vs Turk Farrell | Ninth | 12½ out |
| Thursday, June 17 |
| » Lost to Cubs (27-33), 6-5 | Astrodome (17-14) | 27-37 | |
| » Starters: Bob Hendley vs Dave Giusti | Eighth | 13½ out |
| Future Astro Mike Magnante is born in Glendale, CA. |
| Friday, June 18 |
| » Defeated Pirates (32-29), 5-1 | Astrodome (18-14) | 28-37 | |
| » Starters: Bob Veale vs Bob Bruce | Ninth | 12½ out |
| Saturday, June 19 |
| » Lost to Pirates (33-29), 5-3 | Astrodome (18-15) | 28-38 | |
| » Starters: Don Cardwell vs Claude Raymond | Ninth | 13½ out |
| Sunday, June 20 |
| » Lost to Phillies (31-31), 3-2 | Astrodome (18-16) | 28-39 | Lost 2 |
| » Starters: Jim Bunning vs Larry Dierker | Ninth | 14½ out |
| » Lost to Phillies (32-31), 7-1 | Astrodome (18-17) | 28-40 | Lost 3 |
| » Starters: Bo Belinsky vs Mike Cuellar | Ninth | 14½ out |
| Former Astro Jay Dahl dies in Salisbury, NC at the age of 20. |
| Monday, June 21 |
| » Defeated Phillies (32-32), 6-2 | Astrodome (19-17) | 29-40 | |
| » Starters: Ray Culp vs Turk Farrell | Ninth | 13½ out |
| Tuesday, June 22 |
| » Lost to Phillies (33-32), 7-2 | Astrodome (19-18) | 29-41 | |
| » Starters: Chris Short vs Bob Bruce | Ninth | 14½ out |
| Thursday, June 24 |
| » Defeated Mets (23-46), 4-2 | Astrodome (20-18) | 30-41 | |
| » Starters: Jack Fisher vs Claude Raymond | Ninth | 13½ out |
| Friday, June 25 |
| » Defeated Mets (23-47), 6-2 | Astrodome (21-18) | 31-41 | Won 2 |
| » Starters: Warren Spahn vs Larry Dierker | Ninth | 13½ out |
| Saturday, June 26 |
| » Defeated Mets (23-48), 2-0 | Astrodome (22-18) | 32-41 | Won 3 |
| » Starters: Frank Lary vs Turk Farrell | Ninth | 12½ out |
| Sunday, June 27 |
| » Defeated Mets (23-49), 4-2 | Astrodome (23-18) | 33-41 | Won 4 |
| » Starters: Al Jackson vs Bob Bruce | Ninth | 11½ out |
| Monday, June 28 |
| » Lost to Cubs (33-39), 7-2 | Wrigley Field (3-2) | 33-42 | |
| » Starters: Dave Giusti vs Larry Jackson | Ninth | 11½ out |
| Wednesday, June 30 |
| » Defeated Giants (40-33), 6-4 | Astrodome (24-18) | 34-42 | |
| » Starters: Gaylord Perry vs Turk Farrell | Ninth | 11½ out |
| Friday, July 2 |
| » Defeated Dodgers (46-33), 4-3 | Astrodome (25-18) | 35-42 | Won 2 |
| » Starters: Don Drysdale vs Bob Bruce | Ninth | 10 out |
| Saturday, July 3 |
| » Lost to Dodgers (47-33), 3-1 | Astrodome (25-19) | 35-43 | |
| » Starters: Sandy Koufax vs Larry Dierker | Ninth | 11 out |
| Sunday, July 4 |
| » Defeated Dodgers (47-34), 3-1 | Astrodome (26-19) | 36-43 | |
| » Starters: Claude Osteen vs Claude Raymond | Ninth | 10 out |
| Monday, July 5 |
| » Defeated Braves (38-37), 5-4 | County Stadium (1-2) | 37-43 | Won 2 |
| » Starters: Turk Farrell vs Wade Blasingame | Eighth | 9 out |
| Wednesday, July 7 |
| » Lost to Braves (39-37), 5-2 | County Stadium (1-3) | 37-44 | |
| » Starters: Bob Bruce vs Ken Johnson | Eighth | 9½ out |
| Thursday, July 8 |
| » Lost to Braves (40-37), 9-8 | County Stadium (1-4) | 37-45 | Lost 2 |
| » Starters: Don Nottebart vs Tony Cloninger | Ninth | 10½ out |
| Friday, July 9 |
| » Defeated Mets (29-55), 6-2 | Shea Stadium (2-1) | 38-45 | |
| » Starters: Larry Dierker vs Jack Fisher | Eighth | 10 out |
| » Major-league debuts: Dennis Musgraves (Mets) |
| Saturday, July 10 |
| » Defeated Mets (29-56), 10-1 | Shea Stadium (3-1) | 39-45 | Won 2 |
| » Starters: Turk Farrell vs Warren Spahn | Eighth | 10 out |
| Thursday, July 15 |
| Future Astro Kirt Manwaring is born in Elmira, NY. |
| Friday, July 16 |
| » Lost to Giants (46-38), 2-1 | Candlestick Park (0-5) | 39-46 | |
| » Starters: Bob Bruce vs Bob Shaw | Ninth | 11 out |
| Saturday, July 17 |
| » Lost to Giants (47-38), 7-0 | Candlestick Park (0-6) | 39-47 | Lost 2 |
| » Starters: Turk Farrell vs Juan Marichal | Ninth | 12 out |
| Sunday, July 18 |
| » Defeated Giants (47-39), 5-2 | Candlestick Park (1-6) | 40-47 | |
| » Starters: Claude Raymond vs Gaylord Perry | Eighth | 12 out |
| Monday, July 19 |
| » Lost to Dodgers (56-38), 8-3 | Dodger Stadium (1-4) | 40-48 | |
| » Starters: Don Nottebart vs Don Drysdale | Ninth | 13 out |
| Tuesday, July 20 |
| » Lost to Dodgers (57-38), 3-2 | Dodger Stadium (1-5) | 40-49 | Lost 2 |
| » Starters: Mike Cuellar vs Sandy Koufax | Ninth | 14 out |
| Wednesday, July 21 |
| » Defeated Cardinals (46-47), 2-0 | Astrodome (27-19) | 41-49 | |
| » Starters: Bob Gibson vs Bob Bruce | Ninth | 13 out |
| Thursday, July 22 |
| » Defeated Cardinals (46-48), 3-2 | Astrodome (28-19) | 42-49 | Won 2 |
| » Starters: Bob Purkey vs Larry Dierker | Ninth | 12 out |
| Friday, July 23 |
| » Lost to Reds (54-41), 9-1 | Astrodome (28-20) | 42-50 | |
| » Starters: Joey Jay vs Claude Raymond | Ninth | 12 out |
| Saturday, July 24 |
| » Defeated Reds (54-42), 4-2 | Astrodome (29-20) | 43-50 | |
| » Starters: Sammy Ellis vs Don Nottebart | Eighth | 11½ out |
| » Lost to Reds (55-42), 2-0 | Astrodome (29-21) | 43-51 | |
| » Starters: Joe Nuxhall vs Turk Farrell | Eighth | 11½ out |
| » Major-league debuts: Ted Davidson (Reds) |
| Sunday, July 25 |
| » Lost to Reds (56-42), 3-1 | Astrodome (29-22) | 43-52 | Lost 2 |
| » Starters: John Tsitouris vs Mike Cuellar | Ninth | 12½ out |
| Monday, July 26 |
| » Lost to Braves (52-43), 6-0 | Astrodome (29-23) | 43-53 | Lost 3 |
| » Starters: Wade Blasingame vs Bob Bruce | Ninth | 13½ out |
| Tuesday, July 27 |
| » Lost to Braves (53-43), 7-1 | Astrodome (29-24) | 43-54 | Lost 4 |
| » Starters: Tony Cloninger vs Larry Dierker | Ninth | 14½ out |
| Wednesday, July 28 |
| » Lost to Braves (54-43), 6-4 | Astrodome (29-25) | 43-55 | Lost 5 |
| » Starters: Ken Johnson vs Turk Farrell | Ninth | 14½ out |
| Friday, July 30 |
| » Lost to Reds (58-44), 7-1 | Crosley Field (1-2) | 43-56 | Lost 6 |
| » Starters: Don Nottebart vs Joe Nuxhall | Ninth | 15½ out |
| Saturday, July 31 |
| » Lost to Reds (59-44), 11-4 | Crosley Field (1-3) | 43-57 | Lost 7 |
| » Starters: Bob Bruce vs Jim Maloney | Ninth | 15½ out |
| Sunday, August 1 |
| » Lost to Reds (60-44), 6-4 | Crosley Field (1-4) | 43-58 | Lost 8 |
| » Starters: Mike Cuellar vs Joey Jay | Ninth | 16 out |
| » Defeated Reds (60-45), 7-6 | Crosley Field (2-4) | 44-58 | |
| » Starters: Dave Giusti vs John Tsitouris | Ninth | 16 out |
| Tuesday, August 3 |
| » Defeated Cardinals (52-53), 10-7 | Sportsman's Park III (3-1) | 45-58 | Won 2 |
| » Starters: Larry Dierker vs Bob Purkey | Ninth | 15½ out |
| » Lost to Cardinals (53-53), 7-0 | Sportsman's Park III (3-2) | 45-59 | |
| » Starters: Turk Farrell vs Ray Washburn | Ninth | 15½ out |
| Wednesday, August 4 |
| » Lost to Cardinals (54-53), 9-4 | Sportsman's Park III (3-3) | 45-60 | Lost 2 |
| » Starters: Don Nottebart vs Curt Simmons | Ninth | 16 out |
| Thursday, August 5 |
| » Lost to Cardinals (55-53), 3-1 | Sportsman's Park III (3-4) | 45-61 | Lost 3 |
| » Starters: Bob Bruce vs Bob Gibson | Ninth | 17 out |
| Friday, August 6 |
| » Lost to Braves (59-47), 8-4 | County Stadium (1-5) | 45-62 | Lost 4 |
| » Starters: Ron Taylor vs Tony Cloninger | Ninth | 17 out |
| Saturday, August 7 |
| » Defeated Braves (59-48), 4-0 | County Stadium (2-5) | 46-62 | |
| » Starters: Turk Farrell vs Ken Johnson | Ninth | 17 out |
| Sunday, August 8 |
| » Lost to Braves (60-48), 8-5 | County Stadium (2-6) | 46-63 | |
| » Starters: Don Nottebart vs Wade Blasingame | Ninth | 17½ out |
| » Lost to Braves (61-48), 8-3 | County Stadium (2-7) | 46-64 | Lost 2 |
| » Starters: Larry Dierker vs Denny Lemaster | Ninth | 17½ out |
| Monday, August 9 |
| » Defeated Phillies (58-53), 8-0 | Astrodome (30-25) | 47-64 | |
| » Starters: Lew Burdette vs Robin Roberts | Ninth | 17 out |
| Tuesday, August 10 |
| » Lost to Phillies (59-53), 2-0 | Astrodome (30-26) | 47-65 | |
| » Starters: Jim Bunning vs Bob Bruce | Ninth | 18 out |
| Future Astro Al Osuna is born in Inglewood, CA. |
| Wednesday, August 11 |
| » Lost to Phillies (60-53), 5-1 | Astrodome (30-27) | 47-66 | Lost 2 |
| » Starters: Ray Culp vs Danny Coombs | Ninth | 19 out |
| Thursday, August 12 |
| » Lost to Phillies (61-53), 7-3 | Astrodome (30-28) | 47-67 | Lost 3 |
| » Starters: Chris Short vs Turk Farrell | Ninth | 19½ out |
| Friday, August 13 |
| » Defeated Mets (34-81), 3-2 | Astrodome (31-28) | 48-67 | |
| » Starters: Jack Fisher vs Don Nottebart | Ninth | 19½ out |
| Saturday, August 14 |
| » Lost to Mets (35-81), 1-0 | Astrodome (31-29) | 48-68 | |
| » Starters: Galen Cisco vs Larry Dierker | Ninth | 20½ out |
| Sunday, August 15 |
| » Lost to Mets (36-81), 3-0 | Astrodome (31-30) | 48-69 | Lost 2 |
| » Starters: Al Jackson vs Bob Bruce | Ninth | 20½ out |
| Monday, August 16 |
| » Defeated Pirates (61-60), 3-0 | Astrodome (32-30) | 49-69 | |
| » Starters: Bob Friend vs Robin Roberts | Ninth | 19½ out |
| Future Astro Xavier Hernandez is born in Port Arthur, TX. |
| Tuesday, August 17 |
| » Lost to Pirates (62-60), 8-6 | Astrodome (32-31) | 49-70 | |
| » Starters: Vern Law vs Turk Farrell | Ninth | 20½ out |
| Wednesday, August 18 |
| » Lost to Pirates (63-60), 8-7 | Astrodome (32-32) | 49-71 | Lost 2 |
| » Starters: Bob Veale vs Don Nottebart | Ninth | 21 out |
| Friday, August 20 |
| » Defeated Cubs (57-67), 7-4 | Wrigley Field (4-2) | 50-71 | |
| » Starters: Bob Bruce vs Bob Buhl | Ninth | 21 out |
| » Lost to Cubs (58-67), 2-0 | Wrigley Field (4-3) | 50-72 | |
| » Starters: Larry Dierker vs Bill Faul | Ninth | 21 out |
| Saturday, August 21 |
| » Defeated Cubs (58-68), 9-2 | Wrigley Field (5-3) | 51-72 | |
| » Starters: Robin Roberts vs Dick Ellsworth | Ninth | 20½ out |
| Sunday, August 22 |
| » Lost to Cubs (59-68), 3-1 | Wrigley Field (5-4) | 51-73 | |
| » Starters: Turk Farrell vs Billy Hoeft | Ninth | 20½ out |
| Tuesday, August 24 |
| » Defeated Phillies (66-58), 4-3 | Shibe Park (2-5) | 52-73 | |
| » Starters: Don Nottebart vs Chris Short | Ninth | 20 out |
| Wednesday, August 25 |
| » Defeated Phillies (66-59), 7-6 | Shibe Park (3-5) | 53-73 | Won 2 |
| » Starters: Bob Bruce vs Ray Culp | Ninth | 19 out |
| Thursday, August 26 |
| » Defeated Phillies (66-60), 6-4 | Shibe Park (4-5) | 54-73 | Won 3 |
| » Starters: Robin Roberts vs Jim Bunning | Eighth | 18 out |
| Friday, August 27 |
| » Lost to Pirates (70-61), 10-9 | Forbes Field (1-6) | 54-74 | |
| » Starters: Turk Farrell vs Vern Law | Eighth | 19 out |
| Saturday, August 28 |
| » Defeated Pirates (70-62), 9-6 | Forbes Field (2-6) | 55-74 | |
| » Starters: Larry Dierker vs Don Cardwell | Ninth | 19 out |
| Sunday, August 29 |
| » Lost to Pirates (71-62), 4-2 | Forbes Field (2-7) | 55-75 | |
| » Starters: Don Nottebart vs Bob Friend | Ninth | 19 out |
| Tuesday, August 31 |
| » Defeated Mets (43-89), 4-3 | Shea Stadium (4-1) | 56-75 | |
| » Starters: Robin Roberts vs Larry Miller | Eighth | 18 out |
| » Defeated Mets (43-90), 3-2 | Shea Stadium (5-1) | 57-75 | Won 2 |
| » Starters: Bob Bruce vs Tug McGraw | Eighth | 18 out |
| Wednesday, September 1 |
| » Lost to Mets (44-90), 4-1 | Shea Stadium (5-2) | 57-76 | |
| » Starters: Danny Coombs vs Al Jackson | Ninth | 17 out |
| » Defeated Mets (44-91), 8-5 | Shea Stadium (6-2) | 58-76 | |
| » Starters: Turk Farrell vs Rob Gardner | Ninth | 17 out |
| » Major-league debuts: Kevin Collins and Rob Gardner (Mets) |
| Thursday, September 2 |
| » Defeated Mets (44-92), 4-3 | Shea Stadium (7-2) | 59-76 | Won 2 |
| » Starters: Larry Dierker vs Jack Fisher | Ninth | 17 out |
| » Major-league debuts: Bud Harrelson and Dick Selma (Mets) |
| Friday, September 3 |
| » Lost to Dodgers (77-59), 3-0 | Astrodome (32-33) | 59-77 | |
| » Starters: Nick Willhite vs Don Nottebart | Ninth | 18 out |
| Saturday, September 4 |
| » Lost to Dodgers (78-59), 5-0 | Astrodome (32-34) | 59-78 | Lost 2 |
| » Starters: Jim Brewer vs Bob Bruce | Ninth | 19 out |
| Sunday, September 5 |
| » Lost to Dodgers (79-59), 4-2 | Astrodome (32-35) | 59-79 | Lost 3 |
| » Starters: Sandy Koufax vs Robin Roberts | Ninth | 20 out |
| Future Astro Jeff Baldwin is born in Milford, DE. |
| Monday, September 6 |
| » Defeated Cubs (65-76), 2-1 | Astrodome (33-35) | 60-79 | |
| » Starters: Larry Jackson vs Turk Farrell | Eighth | 19 out |
| Tuesday, September 7 |
| » Major-league debuts: Luke Walker (Pirates) |
| Wednesday, September 8 |
| » Lost to Giants (78-59), 12-3 | Candlestick Park (1-7) | 60-80 | |
| » Starters: Don Nottebart vs Bobby Bolin | Eighth | 19½ out |
| Thursday, September 9 |
| » Lost to Giants (79-59), 4-0 | Candlestick Park (1-8) | 60-81 | Lost 2 |
| » Starters: Bob Bruce vs Juan Marichal | Eighth | 20½ out |
| Friday, September 10 |
| » Lost to Dodgers (81-61), 5-2 | Dodger Stadium (1-6) | 60-82 | Lost 3 |
| » Starters: Robin Roberts vs Don Drysdale | Ninth | 21½ out |
| Saturday, September 11 |
| » Lost to Dodgers (82-61), 8-3 | Dodger Stadium (1-7) | 60-83 | Lost 4 |
| » Starters: Turk Farrell vs Claude Osteen | Ninth | 22½ out |
| » Major-league debuts: Norm Miller (Astros) |
| Sunday, September 12 |
| » Defeated Dodgers (82-62), 3-2 | Dodger Stadium (2-7) | 61-83 | |
| » Starters: Larry Dierker vs Johnny Podres | Ninth | 23 out |
| Monday, September 13 |
| » Lost to Giants (84-59), 5-1 | Astrodome (33-36) | 61-84 | |
| » Starters: Juan Marichal vs Don Nottebart | Ninth | 24 out |
| Tuesday, September 14 |
| » Lost to Giants (85-59), 7-5 | Astrodome (33-37) | 61-85 | Lost 2 |
| » Starters: Ron Herbel vs Bob Bruce | Eighth | 25 out |
| Wednesday, September 15 |
| » Lost to Giants (86-59), 3-2 | Astrodome (33-38) | 61-86 | Lost 3 |
| » Starters: Bob Shaw vs Robin Roberts | Ninth | 26 out |
| » Major-league debuts: Chuck Harrison (Astros) |
| Thursday, September 16 |
| » Lost to Giants (87-59), 5-1 | Astrodome (33-39) | 61-87 | Lost 4 |
| » Starters: Bobby Bolin vs Turk Farrell | Eighth | 27 out |
| » Major-league debuts: Jim Ray (Astros) |
| Friday, September 17 |
| » Lost to Reds (84-64), 4-2 | Crosley Field (2-5) | 61-88 | Lost 5 |
| » Starters: Larry Dierker vs Sammy Ellis | Eighth | 27 out |
| Sunday, September 19 |
| » Defeated Reds (84-65), 8-6 | Crosley Field (3-5) | 62-88 | |
| » Starters: Bob Bruce vs Joey Jay | Ninth | 28 out |
| » Lost to Reds (85-65), 4-3 | Crosley Field (3-6) | 62-89 | |
| » Starters: Jack Lamabe vs Joe Nuxhall | Ninth | 28 out |
| Tuesday, September 21 |
| » Lost to Cardinals (74-76), 3-0 | Sportsman's Park III (3-5) | 62-90 | Lost 2 |
| » Starters: Chris Zachary vs Ray Sadecki | Ninth | 28½ out |
| Wednesday, September 22 |
| » Lost to Cardinals (75-76), 4-1 | Sportsman's Park III (3-6) | 62-91 | Lost 3 |
| » Starters: Jim Ray vs Larry Jaster | Ninth | 28½ out |
| Saturday, September 25 |
| » Lost to Reds (88-66), 1-0 | Astrodome (33-40) | 62-92 | Lost 4 |
| » Starters: Jim Maloney vs Robin Roberts | Ninth | 29 out |
| Sunday, September 26 |
| » Defeated Reds (88-67), 4-2 | Astrodome (34-40) | 63-92 | |
| » Starters: Joe Nuxhall vs Bob Bruce | Eighth | 28 out |
| Monday, September 27 |
| » Defeated Braves (83-73), 4-3 | Astrodome (35-40) | 64-92 | Won 2 |
| » Starters: Wade Blasingame vs Larry Dierker | Eighth | 28 out |
| Tuesday, September 28 |
| » Lost to Braves (84-73), 7-1 | Astrodome (35-41) | 64-93 | |
| » Starters: Tony Cloninger vs Chris Zachary | Ninth | 29 out |
| » Major-league debuts: Bruce Von Hoff (Astros) |
| Wednesday, September 29 |
| » Lost to Braves (85-73), 5-1 | Astrodome (35-42) | 64-94 | Lost 2 |
| » Starters: Ken Johnson vs Jack Lamabe | Ninth | 30 out |
| Thursday, September 30 |
| » Lost to Cardinals (78-80), 19-8 | Astrodome (35-43) | 64-95 | Lost 3 |
| » Starters: Nelson Briles vs Jim Ray | Ninth | 31 out |
| Friday, October 1 |
| » Defeated Cardinals (78-81), 4-2 | Astrodome (36-43) | 65-95 | |
| » Starters: Ray Sadecki vs Robin Roberts | Ninth | 30 out |
| Saturday, October 2 |
| » Lost to Cardinals (79-81), 6-3 | Astrodome (36-44) | 65-96 | |
| » Starters: Larry Jaster vs Don Arlich | Eighth | 31 out |
| » Major-league debuts: Don Arlich (Astros) |
| Sunday, October 3 |
| » Lost to Cardinals (80-81), 5-2 | Astrodome (36-45) | 65-97 | Lost 2 |
| » Starters: Bob Gibson vs Carroll Sembera | Ninth | 32 out |
| Tuesday, December 14 |
| Future Astro Craig Biggio is born in Smithtown, NY. |
| Thursday, December 16 |
| Future Astro Randy Hennis is born in Clearlake, CA. Future Astro Chris Jones is born in Utica, NY. |
| Saturday, December 18 |
| Future Astro Willie Blair is born in Paintsville, KY. |
Game information provided by Retrosheet (www.retrosheet.org) |