| Monday, January 13 |
| Future White Sox Jose Nunez is born in Jarabacoa, D.R. Future White Sox Billy Jo Robidoux is born in Ware, MA. |
| Monday, January 20 |
| Future White Sox Ozzie Guillen is born in Oculare Del Tuy, Venezuela. |
| Friday, January 24 |
| Future White Sox Rob Dibble is born in Bridgeport, CT. |
| Thursday, February 13 |
| Future White Sox Dann Howitt is born in Battle Creek, MI. |
| Tuesday, February 18 |
| Future White Sox Kevin Tapani is born in Des Moines, IA. |
| Saturday, March 7 |
| Future White Sox Wayne Edwards is born in Burbank, CA. |
| Monday, April 6 |
| Future White Sox Ken Williams is born in Berkeley, CA. |
| Wednesday, April 8 |
| Former White Sox George Moriarty dies in Miami, FL at the age of 80. |
| Friday, April 10 |
| Future White Sox Eric King is born in Oxnard, CA. |
| Monday, April 13 |
| » Major-league debuts: Bobby Knoop (Angels) |
| Tuesday, April 14 |
| » Lost to Orioles (1-0), 5-3 | Comiskey Park I (0-1) | 0-1 | |
| » Starters: Milt Pappas vs Gary Peters | Third | 1 out |
| Wednesday, April 15 |
| » Major-league debuts: Dick Kelley and Phil Niekro (Braves) |
| Thursday, April 16 |
| » Lost to Orioles (2-0), 4-3 | Comiskey Park I (0-2) | 0-2 | Lost 2 |
| » Starters: Dave McNally vs Ray Herbert | Sixth | 2 out |
| » Major-league debuts: Jerry McNertney (White Sox) |
| Friday, April 17 |
| » Lost to Red Sox (2-0), 4-1 | Fenway Park (0-1) | 0-3 | Lost 3 |
| » Starters: Joe Horlen vs Jack Lamabe | Seventh | 3 out |
| » Major-league debuts: Dalton Jones (Red Sox) |
| Saturday, April 18 |
| » Defeated Red Sox (2-1), 10-5 | Fenway Park (1-1) | 1-3 | |
| » Starters: Gary Peters vs Earl Wilson | Seventh | 3 out |
| Sunday, April 19 |
| » Defeated Red Sox (2-2), 6-0 | Fenway Park (2-1) | 2-3 | Won 2 |
| » Starters: John Buzhardt vs Ed Connolly | Sixth | 2 out |
| » Major-league debuts: Ed Connolly (Red Sox) |
| Wednesday, April 22 |
| » Lost to Yankees (2-4), 3-0 | Comiskey Park I (0-3) | 2-4 | |
| » Starters: Whitey Ford vs Gary Peters | Seventh | 2½ out |
| Friday, April 24 |
| » Defeated Red Sox (4-4), 6-1 | Comiskey Park I (1-3) | 3-4 | |
| » Starters: Bill Monbouquette vs Juan Pizarro | Seventh | 2 out |
| Saturday, April 25 |
| » Defeated Red Sox (4-5), 4-2 | Comiskey Park I (2-3) | 4-4 | Won 2 |
| » Starters: Ed Connolly vs John Buzhardt | Fourth | 2 out |
| Sunday, April 26 |
| » Defeated Red Sox (4-6), 2-1 | Comiskey Park I (3-3) | 5-4 | Won 3 |
| » Starters: Bill Spanswick vs Fritz Ackley | Third | 1 out |
| Saturday, May 2 |
| » Defeated Angels (6-8), 3-1 | Comiskey Park I (4-3) | 6-4 | Won 4 |
| » Starters: Bo Belinsky vs Gary Peters | Third | 1 out |
| Sunday, May 3 |
| » Defeated Angels (6-9), 3-2 | Comiskey Park I (5-3) | 7-4 | Won 5 |
| » Starters: Ken McBride vs Juan Pizarro | Second | 1 out |
| » Lost to Angels (7-9), 6-2 | Comiskey Park I (5-4) | 7-5 | |
| » Starters: Fred Newman vs John Buzhardt | Second | 1 out |
| Monday, May 4 |
| » Defeated Twins (9-9), 10-5 | Comiskey Park I (6-4) | 8-5 | |
| » Starters: Jim Roland vs Fritz Ackley | Second | 1 out |
| Wednesday, May 6 |
| » Defeated Athletics (7-10), 6-4 | Comiskey Park I (7-4) | 9-5 | Won 2 |
| » Starters: Moe Drabowsky vs Gary Peters | First | -- |
| » Defeated Athletics (7-11), 11-4 | Comiskey Park I (8-4) | 10-5 | Won 3 |
| » Starters: Aurelio Monteagudo vs Ray Herbert | First | -- |
| Friday, May 8 |
| » Defeated Angels (9-12), 3-1 | Dodger Stadium (1-0) | 11-5 | Won 4 |
| » Starters: Juan Pizarro vs Ken McBride | First | -- |
| Saturday, May 9 |
| » Lost to Angels (10-12), 7-4 | Dodger Stadium (1-1) | 11-6 | |
| » Starters: John Buzhardt vs Bo Belinsky | First | -- |
| Sunday, May 10 |
| » Defeated Angels (10-13), 5-3 | Dodger Stadium (2-1) | 12-6 | |
| » Starters: Gary Peters vs Bob Lee | First | -- |
| Tuesday, May 12 |
| » Lost to Twins (13-11), 11-1 | Metropolitan Stadium (0-1) | 12-7 | |
| » Starters: Ray Herbert vs Jim Kaat | First | -- |
| Wednesday, May 13 |
| » Defeated Twins (13-12), 5-1 | Metropolitan Stadium (1-1) | 13-7 | |
| » Starters: Juan Pizarro vs Dick Stigman | First | -- |
| Thursday, May 14 |
| » Lost to Twins (14-12), 15-7 | Metropolitan Stadium (1-2) | 13-8 | |
| » Starters: Gary Peters vs Gerry Arrigo | First | -- |
| Former White Sox Dave Altizer dies in Pleasant Hill, IL at the age of 88. |
| Friday, May 15 |
| » Defeated Senators (13-18), 2-0 | Robert F. Kennedy Stadium (1-0) | 14-8 | |
| » Starters: John Buzhardt vs Claude Osteen | First | -- |
| Saturday, May 16 |
| » Lost to Senators (14-18), 3-1 | Robert F. Kennedy Stadium (1-1) | 14-9 | |
| » Starters: Ray Herbert vs Bennie Daniels | Second | 1 out |
| Sunday, May 17 |
| » Defeated Senators (14-19), 3-2 | Robert F. Kennedy Stadium (2-1) | 15-9 | |
| » Starters: Juan Pizarro vs Alan Koch | First | -- |
| Tuesday, May 19 |
| » Defeated Indians (16-12), 6-5 | Comiskey Park I (9-4) | 16-9 | Won 2 |
| » Starters: Sonny Siebert vs Gary Peters | First | -- |
| Wednesday, May 20 |
| Future White Sox Jeff Schwarz is born in Fort Pierce, FL. |
| Friday, May 22 |
| » Defeated Senators (16-22), 3-1 | Comiskey Park I (10-4) | 17-9 | Won 3 |
| » Starters: Alan Koch vs Juan Pizarro | First | -- |
| Saturday, May 23 |
| » Defeated Senators (16-23), 14-2 | Comiskey Park I (11-4) | 18-9 | Won 4 |
| » Starters: Jim Hannan vs John Buzhardt | First | -- |
| Sunday, May 24 |
| » Defeated Senators (16-24), 6-4 | Comiskey Park I (12-4) | 19-9 | Won 5 |
| » Starters: Claude Osteen vs Ray Herbert | First | -- |
| » Lost to Senators (17-24), 3-0 | Comiskey Park I (12-5) | 19-10 | |
| » Starters: Buster Narum vs Joe Horlen | First | -- |
| Monday, May 25 |
| » Defeated Athletics (12-25), 7-4 | Municipal Stadium (1-0) | 20-10 | |
| » Starters: Gary Peters vs John O'Donoghue | First | -- |
| Thursday, May 28 |
| » Lost to Athletics (13-25), 4-1 | Municipal Stadium (1-1) | 20-11 | |
| » Starters: Juan Pizarro vs Orlando Pena | First | -- |
| Friday, May 29 |
| » Defeated Tigers (18-21), 4-1 | Tiger Stadium (1-0) | 21-11 | |
| » Starters: John Buzhardt vs Dave Wickersham | First | -- |
| Saturday, May 30 |
| » Defeated Tigers (18-22), 10-4 | Tiger Stadium (2-0) | 22-11 | Won 2 |
| » Starters: Joe Horlen vs Hank Aguirre | First | -- |
| Sunday, May 31 |
| » Defeated Tigers (18-23), 5-3 | Tiger Stadium (3-0) | 23-11 | Won 3 |
| » Starters: Eddie Fisher vs Mickey Lolich | First | -- |
| » Defeated Tigers (18-24), 8-3 | Tiger Stadium (4-0) | 24-11 | Won 4 |
| » Starters: Gary Peters vs Ed Rakow | First | -- |
| Monday, June 1 |
| » Lost to Indians (22-16), 3-0 | Cleveland Stadium (0-1) | 24-12 | |
| » Starters: Juan Pizarro vs Jack Kralick | First | -- |
| Tuesday, June 2 |
| » Lost to Indians (23-16), 3-2 | Cleveland Stadium (0-2) | 24-13 | Lost 2 |
| » Starters: John Buzhardt vs Sam McDowell | Second | 3½ out |
| Wednesday, June 3 |
| » Defeated Indians (23-17), 3-0 | Cleveland Stadium (1-2) | 25-13 | |
| » Starters: Joe Horlen vs Tommy John | Second | 3½ out |
| Thursday, June 4 |
| » Defeated Indians (23-18), 5-1 | Cleveland Stadium (2-2) | 26-13 | Won 2 |
| » Starters: Ray Herbert vs Dick Donovan | Second | 3 out |
| Friday, June 5 |
| » Defeated Tigers (18-26), 4-3 | Comiskey Park I (13-5) | 27-13 | Won 3 |
| » Starters: Mickey Lolich vs Juan Pizarro | First | -- |
| Saturday, June 6 |
| » Lost to Tigers (19-26), 4-3 | Comiskey Park I (13-6) | 27-14 | |
| » Starters: Denny McLain vs Gary Peters | Second | 3 out |
| Sunday, June 7 |
| » Defeated Tigers (19-27), 8-3 | Comiskey Park I (14-6) | 28-14 | |
| » Starters: Phil Regan vs John Buzhardt | First | -- |
| » Defeated Tigers (19-28), 2-1 | Comiskey Park I (15-6) | 29-14 | Won 2 |
| » Starters: Hank Aguirre vs Joe Horlen | First | -- |
| Former White Sox Elmer Stricklett dies in Santa Cruz, CA at the age of 88. |
| Tuesday, June 9 |
| » Defeated Orioles (31-18), 9-5 | Comiskey Park I (16-6) | 30-14 | Won 3 |
| » Starters: Dave McNally vs Juan Pizarro | First | -- |
| Wednesday, June 10 |
| » Defeated Orioles (31-19), 2-1 | Comiskey Park I (17-6) | 31-14 | Won 4 |
| » Starters: Robin Roberts vs Gary Peters | First | -- |
| Thursday, June 11 |
| » Lost to Orioles (32-19), 3-1 | Comiskey Park I (17-7) | 31-15 | |
| » Starters: Milt Pappas vs Fred Talbot | First | -- |
| Friday, June 12 |
| » Lost to Yankees (28-21), 6-1 | Yankee Stadium (0-1) | 31-16 | Lost 2 |
| » Starters: John Buzhardt vs Steve Hamilton | First | -- |
| » Lost to Yankees (29-21), 3-0 | Yankee Stadium (0-2) | 31-17 | Lost 3 |
| » Starters: Joe Horlen vs Whitey Ford | First | -- |
| Saturday, June 13 |
| » Lost to Yankees (30-21), 6-3 | Yankee Stadium (0-3) | 31-18 | Lost 4 |
| » Starters: Frank Kreutzer vs Al Downing | First | -- |
| Sunday, June 14 |
| » Lost to Yankees (31-21), 8-3 | Yankee Stadium (0-4) | 31-19 | Lost 5 |
| » Starters: Juan Pizarro vs Bud Daley | Second | 2 out |
| » Lost to Yankees (32-21), 4-3 | Yankee Stadium (0-5) | 31-20 | Lost 6 |
| » Starters: Gary Peters vs Rollie Sheldon | Second | 2 out |
| Monday, June 15 |
| » Defeated Orioles (34-22), 9-1 | Memorial Stadium (1-0) | 32-20 | |
| » Starters: Fred Talbot vs Robin Roberts | First | -- |
| Tuesday, June 16 |
| » Defeated Orioles (34-23), 5-0 | Memorial Stadium (2-0) | 33-20 | Won 2 |
| » Starters: Juan Pizarro vs Milt Pappas | First | -- |
| » Lost to Orioles (35-23), 3-1 | Memorial Stadium (2-1) | 33-21 | |
| » Starters: Joe Horlen vs Steve Barber | First | -- |
| Former White Sox Dick Culler dies in Chapel Hill, NC at the age of 50. |
| Wednesday, June 17 |
| » Lost to Orioles (36-23), 6-1 | Memorial Stadium (2-2) | 33-22 | Lost 2 |
| » Starters: John Buzhardt vs Wally Bunker | Second | 2 out |
| Thursday, June 18 |
| » Defeated Orioles (36-24), 2-0 | Memorial Stadium (3-2) | 34-22 | |
| » Starters: Frank Kreutzer vs Dave McNally | First | -- |
| Saturday, June 20 |
| » Lost to Yankees (35-23), 1-0 | Comiskey Park I (17-8) | 34-23 | |
| » Starters: Whitey Ford vs Gary Peters | Third | 3 out |
| Sunday, June 21 |
| » Lost to Yankees (36-23), 2-0 | Comiskey Park I (17-9) | 34-24 | Lost 2 |
| » Starters: Jim Bouton vs Juan Pizarro | Third | 2½ out |
| » Lost to Yankees (37-23), 2-1 | Comiskey Park I (17-10) | 34-25 | Lost 3 |
| » Starters: Al Downing vs Joe Horlen | Third | 2½ out |
| Monday, June 22 |
| » Lost to Yankees (38-23), 6-5 | Comiskey Park I (17-11) | 34-26 | Lost 4 |
| » Starters: Steve Hamilton vs John Buzhardt | Third | 3½ out |
| Tuesday, June 23 |
| » Defeated Red Sox (32-35), 2-0 | Comiskey Park I (18-11) | 35-26 | |
| » Starters: Jack Lamabe vs Fred Talbot | Third | 3 out |
| Wednesday, June 24 |
| » Defeated Red Sox (32-36), 8-1 | Comiskey Park I (19-11) | 36-26 | Won 2 |
| » Starters: Ed Connolly vs Gary Peters | Third | 3 out |
| Friday, June 26 |
| » Lost to Twins (36-33), 2-0 | Metropolitan Stadium (1-3) | 36-27 | |
| » Starters: Joe Horlen vs Gerry Arrigo | Third | 4 out |
| » Defeated Twins (36-34), 9-4 | Metropolitan Stadium (2-3) | 37-27 | |
| » Starters: Juan Pizarro vs Camilo Pascual | Third | 4 out |
| Saturday, June 27 |
| » Lost to Twins (37-34), 5-3 | Metropolitan Stadium (2-4) | 37-28 | |
| » Starters: John Buzhardt vs Jim Kaat | Third | 5 out |
| Sunday, June 28 |
| » Lost to Twins (38-34), 9-3 | Metropolitan Stadium (2-5) | 37-29 | Lost 2 |
| » Starters: Fred Talbot vs Dick Stigman | Third | 6 out |
| Monday, June 29 |
| » Defeated Indians (33-36), 5-1 | Cleveland Stadium (3-2) | 38-29 | |
| » Starters: Gary Peters vs Sam McDowell | Third | 6 out |
| Tuesday, June 30 |
| » Defeated Indians (33-37), 12-3 | Cleveland Stadium (4-2) | 39-29 | Won 2 |
| » Starters: Juan Pizarro vs Jack Kralick | Third | 5 out |
| Wednesday, July 1 |
| » Defeated Senators (31-46), 8-7 | Comiskey Park I (20-11) | 40-29 | Won 3 |
| » Starters: Buster Narum vs John Buzhardt | Third | 4½ out |
| » Defeated Senators (31-47), 2-1 | Comiskey Park I (21-11) | 41-29 | Won 4 |
| » Starters: Don Rudolph vs Joe Horlen | Third | 4½ out |
| Thursday, July 2 |
| Future White Sox Jose Canseco is born in Havana, Cuba. Future White Sox Joe Magrane is born in Des Moines, IA. |
| Friday, July 3 |
| » Lost to Indians (34-39), 2-1 | Comiskey Park I (21-12) | 41-30 | |
| » Starters: Dick Donovan vs Fred Talbot | Third | 5 out |
| Future White Sox Warren Newson is born in Newnan, GA. |
| Saturday, July 4 |
| » Defeated Indians (34-40), 4-0 | Comiskey Park I (22-12) | 42-30 | |
| » Starters: Sam McDowell vs Gary Peters | Third | 4½ out |
| Sunday, July 5 |
| » Defeated Indians (34-41), 2-0 | Comiskey Park I (23-12) | 43-30 | Won 2 |
| » Starters: Jack Kralick vs Juan Pizarro | Second | 3 out |
| » Defeated Indians (34-42), 5-0 | Comiskey Park I (24-12) | 44-30 | Won 3 |
| » Starters: Lee Stange vs Joe Horlen | Second | 3 out |
| Wednesday, July 8 |
| Future White Sox Ken Patterson is born in Costa Mesa, CA. |
| Thursday, July 9 |
| » Lost to Angels (38-44), 3-0 | Dodger Stadium (2-2) | 44-31 | |
| » Starters: Gary Peters vs Bo Belinsky | Third | 4½ out |
| Friday, July 10 |
| » Defeated Angels (38-45), 7-4 | Dodger Stadium (3-2) | 45-31 | |
| » Starters: Juan Pizarro vs Bob Meyer | Third | 3 out |
| » Defeated Angels (38-46), 6-1 | Dodger Stadium (4-2) | 46-31 | Won 2 |
| » Starters: Joe Horlen vs Barry Latman | Third | 3 out |
| Saturday, July 11 |
| » Lost to Angels (39-46), 1-0 | Dodger Stadium (4-3) | 46-32 | |
| » Starters: Fred Talbot vs Dean Chance | Third | 4 out |
| Sunday, July 12 |
| » Defeated Athletics (31-51), 3-1 | Municipal Stadium (2-1) | 47-32 | |
| » Starters: John Buzhardt vs John O'Donoghue | Third | 3 out |
| » Defeated Athletics (31-52), 11-4 | Municipal Stadium (3-1) | 48-32 | Won 2 |
| » Starters: Eddie Fisher vs Moe Drabowsky | Third | 3 out |
| Monday, July 13 |
| » Defeated Athletics (31-53), 8-6 | Municipal Stadium (4-1) | 49-32 | Won 3 |
| » Starters: Gary Peters vs Jose Santiago | Third | 2½ out |
| » Lost to Athletics (32-53), 8-7 | Municipal Stadium (4-2) | 49-33 | |
| » Starters: Ray Herbert vs Dan Pfister | Third | 2½ out |
| Tuesday, July 14 |
| » Defeated Red Sox (41-46), 4-2 | Fenway Park (3-1) | 50-33 | |
| » Starters: Juan Pizarro vs Earl Wilson | Third | 1½ out |
| Wednesday, July 15 |
| » Lost to Red Sox (42-46), 11-2 | Fenway Park (3-2) | 50-34 | |
| » Starters: Fred Talbot vs Arnold Earley | Third | 2 out |
| Thursday, July 16 |
| » Defeated Red Sox (42-47), 9-3 | Fenway Park (4-2) | 51-34 | |
| » Starters: John Buzhardt vs Jack Lamabe | Third | 1½ out |
| Friday, July 17 |
| » Defeated Athletics (34-56), 6-1 | Comiskey Park I (25-12) | 52-34 | Won 2 |
| » Starters: Moe Drabowsky vs Gary Peters | Third | 1½ out |
| Sunday, July 19 |
| » Defeated Athletics (34-57), 3-2 | Comiskey Park I (26-12) | 53-34 | Won 3 |
| » Starters: Diego Segui vs Juan Pizarro | Second | 1 out |
| » Defeated Athletics (34-58), 4-3 | Comiskey Park I (27-12) | 54-34 | Won 4 |
| » Starters: John O'Donoghue vs Ray Herbert | Second | 1 out |
| Monday, July 20 |
| » Defeated Angels (47-48), 9-0 | Comiskey Park I (28-12) | 55-34 | Won 5 |
| » Starters: Barry Latman vs Fred Talbot | Second | ½ out |
| Tuesday, July 21 |
| » Lost to Angels (48-48), 2-0 | Comiskey Park I (28-13) | 55-35 | |
| » Starters: Bo Belinsky vs John Buzhardt | Third | 1½ out |
| » Lost to Angels (49-48), 3-2 | Comiskey Park I (28-14) | 55-36 | Lost 2 |
| » Starters: Bob Meyer vs Gary Peters | Third | 1½ out |
| Wednesday, July 22 |
| » Lost to Angels (50-48), 3-2 | Comiskey Park I (28-15) | 55-37 | Lost 3 |
| » Starters: Fred Newman vs Joe Horlen | Third | 1½ out |
| Thursday, July 23 |
| » Defeated Angels (50-49), 2-1 | Comiskey Park I (29-15) | 56-37 | |
| » Starters: Dean Chance vs Ray Herbert | Third | 1½ out |
| Friday, July 24 |
| » Lost to Twins (48-48), 6-3 | Comiskey Park I (29-16) | 56-38 | |
| » Starters: Mudcat Grant vs Juan Pizarro | Third | 2 out |
| Saturday, July 25 |
| » Defeated Twins (48-49), 6-5 | Comiskey Park I (30-16) | 57-38 | |
| » Starters: Jim Roland vs Fred Talbot | Third | 2 out |
| Sunday, July 26 |
| » Defeated Twins (48-50), 5-4 | Comiskey Park I (31-16) | 58-38 | Won 2 |
| » Starters: Camilo Pascual vs Gary Peters | Third | 1 out |
| » Defeated Twins (48-51), 3-0 | Comiskey Park I (32-16) | 59-38 | Won 3 |
| » Starters: Dick Stigman vs John Buzhardt | Third | 1 out |
| Former White Sox Harry Smith dies in Dunbar, NE at the age of 75. |
| Monday, July 27 |
| » Major-league debuts: Dave Eilers (Braves) |
| Tuesday, July 28 |
| » Lost to Tigers (49-52), 6-3 | Tiger Stadium (4-1) | 59-39 | |
| » Starters: Joe Horlen vs Mickey Lolich | Third | 1½ out |
| Wednesday, July 29 |
| » Lost to Tigers (50-52), 3-2 | Tiger Stadium (4-2) | 59-40 | Lost 2 |
| » Starters: Ray Herbert vs Hank Aguirre | Third | 2½ out |
| Thursday, July 30 |
| » Defeated Tigers (50-53), 2-0 | Tiger Stadium (5-2) | 60-40 | |
| » Starters: Gary Peters vs Dave Wickersham | Third | 2 out |
| Friday, July 31 |
| » Defeated Senators (41-66), 6-0 | Robert F. Kennedy Stadium (3-1) | 61-40 | Won 2 |
| » Starters: Juan Pizarro vs Bennie Daniels | Third | 1 out |
| Saturday, August 1 |
| » Defeated Senators (41-67), 9-8 | Robert F. Kennedy Stadium (4-1) | 62-40 | Won 3 |
| » Starters: John Buzhardt vs Dave Stenhouse | Third | 1 out |
| Sunday, August 2 |
| » Defeated Senators (41-68), 2-1 | Robert F. Kennedy Stadium (5-1) | 63-40 | Won 4 |
| » Starters: Joe Horlen vs Claude Osteen | Third | 1½ out |
| » Defeated Senators (41-69), 3-1 | Robert F. Kennedy Stadium (6-1) | 64-40 | Won 5 |
| » Starters: Ray Herbert vs Buster Narum | Third | 1½ out |
| Tuesday, August 4 |
| » Lost to Tigers (52-57), 4-3 | Comiskey Park I (32-17) | 64-41 | |
| » Starters: Dave Wickersham vs Gary Peters | Third | 1½ out |
| Wednesday, August 5 |
| » Lost to Tigers (53-57), 3-1 | Comiskey Park I (32-18) | 64-42 | Lost 2 |
| » Starters: Denny McLain vs Juan Pizarro | Third | 1½ out |
| Thursday, August 6 |
| » Lost to Tigers (54-57), 5-2 | Comiskey Park I (32-19) | 64-43 | Lost 3 |
| » Starters: Mickey Lolich vs Joe Horlen | Third | 1½ out |
| Friday, August 7 |
| » Defeated Red Sox (52-58), 2-0 | Comiskey Park I (33-19) | 65-43 | |
| » Starters: Ed Connolly vs Ray Herbert | Third | 1½ out |
| Saturday, August 8 |
| » Defeated Red Sox (52-59), 9-2 | Comiskey Park I (34-19) | 66-43 | Won 2 |
| » Starters: Dave Morehead vs Fred Talbot | Second | 1½ out |
| Sunday, August 9 |
| » Lost to Red Sox (53-59), 6-3 | Comiskey Park I (34-20) | 66-44 | |
| » Starters: Bill Monbouquette vs John Buzhardt | Second | 1½ out |
| » Defeated Red Sox (53-60), 4-1 | Comiskey Park I (35-20) | 67-44 | |
| » Starters: Earl Wilson vs Gary Peters | Second | 1½ out |
| Tuesday, August 11 |
| » Defeated Yankees (65-44), 6-4 | Yankee Stadium (1-5) | 68-44 | Won 2 |
| » Starters: Joe Horlen vs Ralph Terry | Second | 1 out |
| » Defeated Yankees (65-45), 8-2 | Yankee Stadium (2-5) | 69-44 | Won 3 |
| » Starters: Juan Pizarro vs Jim Bouton | Second | 1 out |
| Future White Sox Carlos Martinez is born in LaGuaira, Venezuela. |
| Wednesday, August 12 |
| » Lost to Yankees (66-45), 7-3 | Yankee Stadium (2-6) | 69-45 | |
| » Starters: Ray Herbert vs Mel Stottlemyre | Second | 2 out |
| » Major-league debuts: Mel Stottlemyre (Yankees) |
| Thursday, August 13 |
| » Lost to Yankees (67-45), 5-2 | Yankee Stadium (2-7) | 69-46 | Lost 2 |
| » Starters: Gary Peters vs Al Downing | Second | 3 out |
| Friday, August 14 |
| » Defeated Red Sox (53-64), 11-1 | Fenway Park (5-2) | 70-46 | |
| » Starters: John Buzhardt vs Earl Wilson | Second | 3 out |
| Saturday, August 15 |
| » Lost to Red Sox (54-64), 5-2 | Fenway Park (5-3) | 70-47 | |
| » Starters: Fred Talbot vs Dave Morehead | Second | 3 out |
| Sunday, August 16 |
| » Defeated Red Sox (54-65), 2-1 | Fenway Park (6-3) | 71-47 | |
| » Starters: Joe Horlen vs Ed Connolly | Second | 2 out |
| Monday, August 17 |
| » Defeated Yankees (69-47), 2-1 | Comiskey Park I (36-20) | 72-47 | Won 2 |
| » Starters: Ralph Terry vs Juan Pizarro | Second | 1½ out |
| Former White Sox Happy Felsch dies in Milwaukee, WI at the age of 73. |
| Tuesday, August 18 |
| » Defeated Yankees (69-48), 4-3 | Comiskey Park I (37-20) | 73-47 | Won 3 |
| » Starters: Al Downing vs Gary Peters | Second | 1½ out |
| Wednesday, August 19 |
| » Defeated Yankees (69-49), 4-2 | Comiskey Park I (38-20) | 74-47 | Won 4 |
| » Starters: Jim Bouton vs Ray Herbert | Second | ½ out |
| Thursday, August 20 |
| » Defeated Yankees (69-50), 5-0 | Comiskey Park I (39-20) | 75-47 | Won 5 |
| » Starters: Whitey Ford vs John Buzhardt | First | -- |
| Friday, August 21 |
| » Lost to Orioles (75-47), 4-2 | Comiskey Park I (39-21) | 75-48 | |
| » Starters: Milt Pappas vs Juan Pizarro | Second | ½ out |
| Future White Sox Shawn Hillegas is born in Dos Palos, CA. |
| Saturday, August 22 |
| » Lost to Orioles (76-47), 4-2 | Comiskey Park I (39-22) | 75-49 | Lost 2 |
| » Starters: Frank Bertaina vs Joe Horlen | Second | 1½ out |
| Sunday, August 23 |
| » Lost to Orioles (77-47), 7-3 | Comiskey Park I (39-23) | 75-50 | Lost 3 |
| » Starters: Wally Bunker vs Ray Herbert | Second | 1½ out |
| » Defeated Orioles (77-48), 3-1 | Comiskey Park I (40-23) | 76-50 | |
| » Starters: Steve Barber vs Gary Peters | Second | 1½ out |
| Monday, August 24 |
| » Lost to Twins (63-62), 4-3 | Comiskey Park I (40-24) | 76-51 | |
| » Starters: Jim Kaat vs John Buzhardt | Second | 2 out |
| Tuesday, August 25 |
| » Defeated Twins (63-63), 1-0 | Comiskey Park I (41-24) | 77-51 | |
| » Starters: Dick Stigman vs Juan Pizarro | Second | 1 out |
| Wednesday, August 26 |
| » Defeated Twins (63-64), 2-1 | Comiskey Park I (42-24) | 78-51 | Won 2 |
| » Starters: Camilo Pascual vs Joe Horlen | Second | 1 out |
| Future White Sox Chad Kreuter is born in Greenbrae, CA. |
| Thursday, August 27 |
| » Lost to Twins (64-64), 5-2 | Comiskey Park I (42-25) | 78-52 | |
| » Starters: Mudcat Grant vs Ray Herbert | Second | 1½ out |
| Friday, August 28 |
| » Defeated Orioles (77-51), 2-1 | Memorial Stadium (4-2) | 79-52 | |
| » Starters: Gary Peters vs Wally Bunker | Second | 1½ out |
| » Lost to Orioles (78-51), 8-3 | Memorial Stadium (4-3) | 79-53 | |
| » Starters: John Buzhardt vs Steve Barber | Second | 1½ out |
| Saturday, August 29 |
| » Lost to Orioles (79-51), 5-0 | Memorial Stadium (4-4) | 79-54 | Lost 2 |
| » Starters: Juan Pizarro vs Milt Pappas | Second | 1½ out |
| Sunday, August 30 |
| » Defeated Orioles (79-52), 3-0 | Memorial Stadium (5-4) | 80-54 | |
| » Starters: Joe Horlen vs Robin Roberts | Second | 1½ out |
| Tuesday, September 1 |
| » Lost to Tigers (71-65), 8-0 | Comiskey Park I (42-26) | 80-55 | |
| » Starters: Mickey Lolich vs Ray Herbert | Second | 1½ out |
| Wednesday, September 2 |
| » Defeated Tigers (71-66), 7-0 | Comiskey Park I (43-26) | 81-55 | |
| » Starters: Hank Aguirre vs Gary Peters | Second | 1½ out |
| Friday, September 4 |
| » Defeated Indians (67-68), 6-5 | Comiskey Park I (44-26) | 82-55 | Won 2 |
| » Starters: Luis Tiant vs Juan Pizarro | Second | 1 out |
| Saturday, September 5 |
| » Defeated Indians (67-69), 8-2 | Comiskey Park I (45-26) | 83-55 | Won 3 |
| » Starters: Sonny Siebert vs Joe Horlen | First | -- |
| » Major-league debuts: Vern Fuller (Indians) |
| Sunday, September 6 |
| » Lost to Indians (68-69), 2-0 | Comiskey Park I (45-27) | 83-56 | |
| » Starters: Jack Kralick vs Gary Peters | First | -- |
| » Defeated Indians (68-70), 3-2 | Comiskey Park I (46-27) | 84-56 | |
| » Starters: Dick Donovan vs John Buzhardt | First | -- |
| Monday, September 7 |
| » Lost to Senators (54-86), 3-0 | Robert F. Kennedy Stadium (6-2) | 84-57 | |
| » Starters: Ray Herbert vs Bennie Daniels | Second | 1½ out |
| » Lost to Senators (55-86), 6-2 | Robert F. Kennedy Stadium (6-3) | 84-58 | Lost 2 |
| » Starters: Fred Talbot vs Dave Stenhouse | Second | 1½ out |
| Tuesday, September 8 |
| Former White Sox Buck Redfern dies in Asheville, NC at the age of 63. |
| Wednesday, September 9 |
| » Lost to Twins (71-70), 5-2 | Metropolitan Stadium (2-6) | 84-59 | Lost 3 |
| » Starters: Juan Pizarro vs Mudcat Grant | Second | 1 out |
| Thursday, September 10 |
| » Defeated Twins (71-71), 2-1 | Metropolitan Stadium (3-6) | 85-59 | |
| » Starters: Joe Horlen vs Jim Kaat | Second | 1 out |
| Friday, September 11 |
| » Defeated Indians (70-72), 7-3 | Cleveland Stadium (5-2) | 86-59 | Won 2 |
| » Starters: Gary Peters vs Jack Kralick | Second | ½ out |
| Future White Sox Ellis Burks is born in Vicksburg, MS. |
| Saturday, September 12 |
| » Lost to Indians (71-72), 11-10 | Cleveland Stadium (5-3) | 86-60 | |
| » Starters: Ray Herbert vs Sam McDowell | Second | 1½ out |
| Sunday, September 13 |
| » Lost to Indians (72-72), 5-4 | Cleveland Stadium (5-4) | 86-61 | Lost 2 |
| » Starters: Juan Pizarro vs Luis Tiant | Third | 1½ out |
| Future White Sox Greg Hibbard is born in New Orleans, LA. |
| Tuesday, September 15 |
| » Defeated Tigers (77-70), 3-2 | Tiger Stadium (6-2) | 87-61 | |
| » Starters: Joe Horlen vs Dave Wickersham | Second | 1 out |
| » Major-league debuts: Marv Staehle (White Sox) |
| Wednesday, September 16 |
| » Defeated Tigers (77-71), 4-1 | Tiger Stadium (7-2) | 88-61 | Won 2 |
| » Starters: Gary Peters vs Mickey Lolich | First | -- |
| Friday, September 18 |
| » Lost to Senators (58-92), 5-4 | Comiskey Park I (46-28) | 88-62 | |
| » Starters: Claude Osteen vs Juan Pizarro | Third | 2 out |
| Saturday, September 19 |
| » Lost to Senators (59-92), 1-0 | Comiskey Park I (46-29) | 88-63 | Lost 2 |
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