| Tuesday, January 7 |
| Future Twin Allan Anderson is born in Lancaster, OH. |
| Tuesday, February 18 |
| Future Twin Kevin Tapani is born in Des Moines, IA. |
| Monday, April 13 |
| » Major-league debuts: Bobby Knoop (Angels) |
| Tuesday, April 14 |
| » Defeated Indians (0-1), 7-6 | Cleveland Stadium (1-0) | 1-0 | |
| » Starters: Camilo Pascual vs Mudcat Grant | First | -- |
| Wednesday, April 15 |
| » Major-league debuts: Dick Kelley and Phil Niekro (Braves) |
| Thursday, April 16 |
| » Defeated Senators (1-2), 6-2 | Robert F. Kennedy Stadium (1-0) | 2-0 | Won 2 |
| » Starters: Jim Kaat vs Carl Bouldin | First | -- |
| Friday, April 17 |
| » Lost to Senators (2-2), 4-3 | Robert F. Kennedy Stadium (1-1) | 2-1 | |
| » Starters: Lee Stange vs Tom Cheney | Third | 1 out |
| Saturday, April 18 |
| » Defeated Senators (2-3), 8-6 | Robert F. Kennedy Stadium (2-1) | 3-1 | |
| » Starters: Dick Stigman vs Dave Stenhouse | Second | 1 out |
| » Major-league debuts: Mike Brumley (Senators) Joe Nossek (Twins) |
| Sunday, April 19 |
| » Defeated Tigers (2-2), 12-3 | Tiger Stadium (1-0) | 4-1 | Won 2 |
| » Starters: Camilo Pascual vs Phil Regan | Second | ½ out |
| » Lost to Tigers (3-2), 3-1 | Tiger Stadium (1-1) | 4-2 | |
| » Starters: Jim Roland vs Dave Wickersham | Second | ½ out |
| Wednesday, April 22 |
| » Defeated Senators (2-5), 7-6 | Metropolitan Stadium (1-0) | 5-2 | |
| » Starters: Howie Koplitz vs Jim Kaat | Second | 1 out |
| Future Twin Jack Savage is born in Louisville, KY. |
| Thursday, April 23 |
| » Lost to Senators (3-5), 5-4 | Metropolitan Stadium (1-1) | 5-3 | |
| » Starters: Carl Bouldin vs Lee Stange | Third | 2 out |
| Friday, April 24 |
| » Lost to Tigers (5-3), 5-0 | Metropolitan Stadium (1-2) | 5-4 | Lost 2 |
| » Starters: Mickey Lolich vs Dick Stigman | Fourth | 2 out |
| Saturday, April 25 |
| » Lost to Tigers (6-3), 5-2 | Metropolitan Stadium (1-3) | 5-5 | Lost 3 |
| » Starters: Dave Wickersham vs Camilo Pascual | Fifth | 2 out |
| Sunday, April 26 |
| » Defeated Tigers (6-4), 3-2 | Metropolitan Stadium (2-3) | 6-5 | |
| » Starters: Phil Regan vs Jim Kaat | Fourth | 2 out |
| Tuesday, April 28 |
| » Defeated Indians (5-3), 9-8 | Metropolitan Stadium (3-3) | 7-5 | Won 2 |
| » Starters: Dick Donovan vs Jim Roland | Second | 2 out |
| Thursday, April 30 |
| » Lost to Indians (6-3), 8-4 | Metropolitan Stadium (3-4) | 7-6 | |
| » Starters: Pedro Ramos vs Dick Stigman | Fourth | 2 out |
| Future Twin Jeff Reboulet is born in Dayton, OH. |
| Friday, May 1 |
| » Defeated Athletics (4-7), 10-5 | Municipal Stadium (1-0) | 8-6 | |
| » Starters: Camilo Pascual vs Moe Drabowsky | Second | 2½ out |
| Saturday, May 2 |
| » Defeated Athletics (4-8), 7-3 | Municipal Stadium (2-0) | 9-6 | Won 2 |
| » Starters: Lee Stange vs Aurelio Monteagudo | Second | 2½ out |
| Sunday, May 3 |
| » Lost to Athletics (5-8), 7-4 | Municipal Stadium (2-1) | 9-7 | |
| » Starters: Jim Kaat vs Diego Segui | Fourth | 2½ out |
| » Lost to Athletics (6-8), 8-7 | Municipal Stadium (2-2) | 9-8 | Lost 2 |
| » Starters: Dick Stigman vs John O'Donoghue | Fourth | 2½ out |
| Monday, May 4 |
| » Lost to White Sox (8-5), 10-5 | Comiskey Park I (0-1) | 9-9 | Lost 3 |
| » Starters: Jim Roland vs Fritz Ackley | Fifth | 2½ out |
| Tuesday, May 5 |
| » Major-league debuts: Tom Kelley (Indians) |
| Wednesday, May 6 |
| » Lost to Angels (9-10), 4-3 | Metropolitan Stadium (3-5) | 9-10 | Lost 4 |
| » Starters: Don Lee vs Camilo Pascual | Fourth | 3 out |
| Thursday, May 7 |
| » Defeated Angels (9-11), 9-1 | Metropolitan Stadium (4-5) | 10-10 | |
| » Starters: Fred Newman vs Jim Kaat | Fifth | 3 out |
| Friday, May 8 |
| » Lost to Athletics (8-11), 6-5 | Metropolitan Stadium (4-6) | 10-11 | |
| » Starters: Diego Segui vs Gerry Arrigo | Fifth | 3½ out |
| Saturday, May 9 |
| » Defeated Athletics (8-12), 10-8 | Metropolitan Stadium (5-6) | 11-11 | |
| » Starters: Orlando Pena vs Lee Stange | Fourth | 2½ out |
| Sunday, May 10 |
| » Defeated Athletics (8-13), 6-3 | Metropolitan Stadium (6-6) | 12-11 | Won 2 |
| » Starters: Aurelio Monteagudo vs Camilo Pascual | Fifth | 2½ out |
| Tuesday, May 12 |
| » Defeated White Sox (12-7), 11-1 | Metropolitan Stadium (7-6) | 13-11 | Won 3 |
| » Starters: Ray Herbert vs Jim Kaat | Fifth | 2½ out |
| Wednesday, May 13 |
| » Lost to White Sox (13-7), 5-1 | Metropolitan Stadium (7-7) | 13-12 | |
| » Starters: Juan Pizarro vs Dick Stigman | Fifth | 2½ out |
| Thursday, May 14 |
| » Defeated White Sox (13-8), 15-7 | Metropolitan Stadium (8-7) | 14-12 | |
| » Starters: Gary Peters vs Gerry Arrigo | Fifth | 2½ out |
| Friday, May 15 |
| » Defeated Red Sox (10-16), 1-0 | Fenway Park (1-0) | 15-12 | Won 2 |
| » Starters: Camilo Pascual vs Bill Monbouquette | Fifth | 2½ out |
| Saturday, May 16 |
| » Lost to Red Sox (11-16), 6-5 | Fenway Park (1-1) | 15-13 | |
| » Starters: Lee Stange vs Jack Lamabe | Fifth | 2½ out |
| Sunday, May 17 |
| » Lost to Red Sox (12-16), 6-2 | Fenway Park (1-2) | 15-14 | Lost 2 |
| » Starters: Jim Kaat vs Dave Morehead | Fifth | 3 out |
| » Defeated Red Sox (12-17), 6-5 | Fenway Park (2-2) | 16-14 | |
| » Starters: Dick Stigman vs Earl Wilson | Fifth | 3 out |
| Tuesday, May 19 |
| » Defeated Yankees (16-11), 7-2 | Yankee Stadium (1-0) | 17-14 | Won 2 |
| » Starters: Jim Roland vs Jim Bouton | Fifth | 3 out |
| Wednesday, May 20 |
| » Defeated Yankees (16-12), 7-4 | Yankee Stadium (2-0) | 18-14 | Won 3 |
| » Starters: Camilo Pascual vs Ralph Terry | Fourth | 3½ out |
| Friday, May 22 |
| » Lost to Orioles (21-12), 6-5 | Memorial Stadium (0-1) | 18-15 | |
| » Starters: Jim Kaat vs Steve Barber | Fourth | 3½ out |
| Saturday, May 23 |
| » Defeated Orioles (21-13), 5-1 | Memorial Stadium (1-1) | 19-15 | |
| » Starters: Lee Stange vs Dave McNally | Fifth | 3½ out |
| Sunday, May 24 |
| » Lost to Orioles (22-13), 2-0 | Memorial Stadium (1-2) | 19-16 | |
| » Starters: Jim Roland vs Robin Roberts | Fifth | 3½ out |
| » Lost to Orioles (23-13), 7-6 | Memorial Stadium (1-3) | 19-17 | Lost 2 |
| » Starters: Dick Stigman vs Milt Pappas | Fifth | 3½ out |
| Monday, May 25 |
| » Defeated Angels (15-24), 8-1 | Dodger Stadium (1-0) | 20-17 | |
| » Starters: Camilo Pascual vs Barry Latman | Fifth | 3½ out |
| Tuesday, May 26 |
| » Defeated Angels (15-25), 2-1 | Dodger Stadium (2-0) | 21-17 | Won 2 |
| » Starters: Jim Kaat vs Ken McBride | Fifth | 4 out |
| Wednesday, May 27 |
| » Lost to Angels (16-25), 4-1 | Dodger Stadium (2-1) | 21-18 | |
| » Starters: Lee Stange vs Bo Belinsky | Fourth | 5 out |
| » Defeated Angels (16-26), 4-3 | Dodger Stadium (3-1) | 22-18 | |
| » Starters: Gerry Arrigo vs Willie Smith | Fourth | 5 out |
| Friday, May 29 |
| » Defeated Red Sox (20-20), 3-2 | Metropolitan Stadium (9-7) | 23-18 | Won 2 |
| » Starters: Jack Lamabe vs Jim Roland | Fourth | 4½ out |
| Saturday, May 30 |
| » Defeated Red Sox (20-21), 7-3 | Metropolitan Stadium (10-7) | 24-18 | Won 3 |
| » Starters: Dave Morehead vs Camilo Pascual | Fourth | 4½ out |
| Sunday, May 31 |
| » Lost to Red Sox (21-21), 4-3 | Metropolitan Stadium (10-8) | 24-19 | |
| » Starters: Earl Wilson vs Lee Stange | Fourth | 4 out |
| Monday, June 1 |
| » Defeated Yankees (21-17), 2-1 | Metropolitan Stadium (11-8) | 25-19 | |
| » Starters: Ralph Terry vs Dick Stigman | Fourth | 4 out |
| Tuesday, June 2 |
| » Defeated Yankees (21-18), 6-2 | Metropolitan Stadium (12-8) | 26-19 | Won 2 |
| » Starters: Jim Bouton vs Gerry Arrigo | Fourth | 3½ out |
| Wednesday, June 3 |
| » Lost to Yankees (22-18), 3-0 | Metropolitan Stadium (12-9) | 26-20 | |
| » Starters: Whitey Ford vs Jim Roland | Fourth | 4½ out |
| Thursday, June 4 |
| » Lost to Yankees (23-18), 9-7 | Metropolitan Stadium (12-10) | 26-21 | Lost 2 |
| » Starters: Al Downing vs Jim Perry | Fourth | 5 out |
| Friday, June 5 |
| » Defeated Orioles (30-16), 11-5 | Metropolitan Stadium (13-10) | 27-21 | |
| » Starters: Milt Pappas vs Lee Stange | Third | 4 out |
| Saturday, June 6 |
| » Lost to Orioles (31-16), 2-1 | Metropolitan Stadium (13-11) | 27-22 | |
| » Starters: Steve Barber vs Dick Stigman | Fourth | 5 out |
| Sunday, June 7 |
| » Defeated Orioles (31-17), 5-2 | Metropolitan Stadium (14-11) | 28-22 | |
| » Starters: Wally Bunker vs Camilo Pascual | Fourth | 4½ out |
| Monday, June 8 |
| » Lost to Tigers (20-28), 10-5 | Tiger Stadium (1-2) | 28-23 | |
| » Starters: Jim Roland vs Dave Wickersham | Fifth | 5 out |
| Tuesday, June 9 |
| » Lost to Tigers (21-28), 16-1 | Tiger Stadium (1-3) | 28-24 | Lost 2 |
| » Starters: Jim Kaat vs Denny McLain | Fifth | 6 out |
| Wednesday, June 10 |
| » Lost to Tigers (22-28), 5-4 | Tiger Stadium (1-4) | 28-25 | Lost 3 |
| » Starters: Lee Stange vs Mickey Lolich | Fifth | 7 out |
| Thursday, June 11 |
| » Defeated Tigers (22-29), 4-2 | Tiger Stadium (2-4) | 29-25 | |
| » Starters: Dick Stigman vs Ed Rakow | Fourth | 6 out |
| Friday, June 12 |
| » Defeated Senators (25-33), 5-3 | Robert F. Kennedy Stadium (3-1) | 30-25 | Won 2 |
| » Starters: Camilo Pascual vs Alan Koch | Fourth | 4½ out |
| Saturday, June 13 |
| » Lost to Senators (26-33), 4-2 | Robert F. Kennedy Stadium (3-2) | 30-26 | |
| » Starters: Jim Roland vs Claude Osteen | Fourth | 4½ out |
| Sunday, June 14 |
| » Defeated Senators (26-34), 6-5 | Robert F. Kennedy Stadium (4-2) | 31-26 | |
| » Starters: Lee Stange vs Buster Narum | Fourth | 3½ out |
| » Defeated Senators (26-35), 9-2 | Robert F. Kennedy Stadium (5-2) | 32-26 | Won 2 |
| » Starters: Jim Kaat vs Tom Cheney | Fourth | 3½ out |
| Tuesday, June 16 |
| » Lost to Indians (28-27), 5-3 | Cleveland Stadium (1-1) | 32-27 | |
| » Starters: Dick Stigman vs Jack Kralick | Fourth | 3½ out |
| Wednesday, June 17 |
| » Lost to Indians (29-27), 3-2 | Cleveland Stadium (1-2) | 32-28 | Lost 2 |
| » Starters: Camilo Pascual vs Sam McDowell | Fifth | 5 out |
| » Lost to Indians (30-27), 5-0 | Cleveland Stadium (1-3) | 32-29 | Lost 3 |
| » Starters: Jim Roland vs Pedro Ramos | Fifth | 5 out |
| Friday, June 19 |
| » Defeated Tigers (26-33), 7-6 | Metropolitan Stadium (15-11) | 33-29 | |
| » Starters: Mickey Lolich vs Jim Kaat | Fourth | 5 out |
| Saturday, June 20 |
| » Lost to Tigers (27-33), 8-7 | Metropolitan Stadium (15-12) | 33-30 | |
| » Starters: Phil Regan vs Mudcat Grant | Fourth | 6 out |
| Sunday, June 21 |
| » Lost to Tigers (28-33), 4-2 | Metropolitan Stadium (15-13) | 33-31 | Lost 2 |
| » Starters: Dave Wickersham vs Dick Stigman | Fourth | 6 out |
| Monday, June 22 |
| » Tied Indians, 8-8 | Metropolitan Stadium (15-13) | 33-31 | |
| » Starters: Sam McDowell vs Camilo Pascual | Fourth | 6½ out |
| Tuesday, June 23 |
| » Defeated Indians (30-31), 6-2 | Metropolitan Stadium (16-13) | 34-31 | |
| » Starters: Pedro Ramos vs Jim Kaat | Fourth | 6 out |
| Wednesday, June 24 |
| » Lost to Indians (31-31), 12-3 | Metropolitan Stadium (16-14) | 34-32 | |
| » Starters: Dick Donovan vs Dick Stigman | Fourth | 6½ out |
| » Defeated Indians (31-32), 3-2 | Metropolitan Stadium (17-14) | 35-32 | |
| » Starters: Sam McDowell vs Jim Roland | Fourth | 6½ out |
| Thursday, June 25 |
| » Lost to Indians (32-32), 8-1 | Metropolitan Stadium (17-15) | 35-33 | |
| » Starters: Jack Kralick vs Mudcat Grant | Fourth | 7½ out |
| Friday, June 26 |
| » Defeated White Sox (36-27), 2-0 | Metropolitan Stadium (18-15) | 36-33 | |
| » Starters: Joe Horlen vs Gerry Arrigo | Fourth | 8 out |
| » Lost to White Sox (37-27), 9-4 | Metropolitan Stadium (18-16) | 36-34 | |
| » Starters: Juan Pizarro vs Camilo Pascual | Fourth | 8 out |
| Saturday, June 27 |
| » Defeated White Sox (37-28), 5-3 | Metropolitan Stadium (19-16) | 37-34 | |
| » Starters: John Buzhardt vs Jim Kaat | Fourth | 8 out |
| Sunday, June 28 |
| » Defeated White Sox (37-29), 9-3 | Metropolitan Stadium (20-16) | 38-34 | Won 2 |
| » Starters: Fred Talbot vs Dick Stigman | Fourth | 8 out |
| Monday, June 29 |
| » Lost to Orioles (46-25), 6-3 | Memorial Stadium (1-4) | 38-35 | |
| » Starters: Camilo Pascual vs Robin Roberts | Fourth | 9 out |
| Tuesday, June 30 |
| » Defeated Orioles (46-26), 3-1 | Memorial Stadium (2-4) | 39-35 | |
| » Starters: Gerry Arrigo vs Steve Barber | Fourth | 8 out |
| Wednesday, July 1 |
| » Defeated Red Sox (36-39), 14-3 | Fenway Park (3-2) | 40-35 | Won 2 |
| » Starters: Mudcat Grant vs Ed Connolly | Fourth | 8 out |
| Thursday, July 2 |
| » Defeated Red Sox (36-40), 15-9 | Fenway Park (4-2) | 41-35 | Won 3 |
| » Starters: Jim Kaat vs Jack Lamabe | Fourth | 7 out |
| Friday, July 3 |
| » Defeated Yankees (43-30), 1-0 | Yankee Stadium (3-0) | 42-35 | Won 4 |
| » Starters: Dick Stigman vs Stan Williams | Fourth | 7 out |
| Saturday, July 4 |
| » Lost to Yankees (44-30), 7-5 | Yankee Stadium (3-1) | 42-36 | |
| » Starters: Gerry Arrigo vs Jim Bouton | Fourth | 8 out |
| » Lost to Yankees (45-30), 2-1 | Yankee Stadium (3-2) | 42-37 | Lost 2 |
| » Starters: Camilo Pascual vs Al Downing | Fourth | 8 out |
| Sunday, July 5 |
| » Defeated Yankees (45-31), 9-2 | Yankee Stadium (4-2) | 43-37 | |
| » Starters: Mudcat Grant vs Whitey Ford | Fourth | 7 out |
| Wednesday, July 8 |
| Future Twin Bob Kipper is born in Aurora, IL. |
| Thursday, July 9 |
| » Defeated Athletics (31-48), 2-1 | Municipal Stadium (3-2) | 44-37 | Won 2 |
| » Starters: Jim Kaat vs Jose Santiago | Fourth | 7½ out |
| Friday, July 10 |
| » Defeated Athletics (31-49), 9-3 | Municipal Stadium (4-2) | 45-37 | Won 3 |
| » Starters: Mudcat Grant vs Diego Segui | Fourth | 6½ out |
| Saturday, July 11 |
| » Defeated Athletics (31-50), 5-4 | Municipal Stadium (5-2) | 46-37 | Won 4 |
| » Starters: Camilo Pascual vs Orlando Pena | Fourth | 6½ out |
| Sunday, July 12 |
| » Lost to Angels (40-46), 2-1 | Dodger Stadium (3-2) | 46-38 | |
| » Starters: Dick Stigman vs Fred Newman | Fourth | 7½ out |
| » Lost to Angels (41-46), 3-2 | Dodger Stadium (3-3) | 46-39 | Lost 2 |
| » Starters: Gerry Arrigo vs Don Lee | Fourth | 7½ out |
| Tuesday, July 14 |
| » Lost to Senators (34-56), 4-3 | Metropolitan Stadium (20-17) | 46-40 | Lost 3 |
| » Starters: Claude Osteen vs Jim Kaat | Fourth | 7 out |
| Wednesday, July 15 |
| » Defeated Senators (34-57), 6-0 | Metropolitan Stadium (21-17) | 47-40 | |
| » Starters: Don Rudolph vs Mudcat Grant | Fourth | 6½ out |
| Thursday, July 16 |
| » Lost to Senators (35-57), 7-2 | Metropolitan Stadium (21-18) | 47-41 | |
| » Starters: Dave Stenhouse vs Camilo Pascual | Fourth | 7 out |
| Friday, July 17 |
| » Lost to Angels (44-47), 1-0 | Metropolitan Stadium (21-19) | 47-42 | Lost 2 |
| » Starters: Fred Newman vs Dick Stigman | Fourth | 8 out |
| Saturday, July 18 |
| » Lost to Angels (45-47), 3-2 | Metropolitan Stadium (21-20) | 47-43 | Lost 3 |
| » Starters: Bo Belinsky vs Jim Kaat | Fourth | 8½ out |
| Sunday, July 19 |
| » Lost to Angels (46-47), 8-6 | Metropolitan Stadium (21-21) | 47-44 | Lost 4 |
| » Starters: Don Lee vs Gerry Arrigo | Fourth | 10 out |
| » Lost to Angels (47-47), 4-0 | Metropolitan Stadium (21-22) | 47-45 | Lost 5 |
| » Starters: Dean Chance vs Mudcat Grant | Fourth | 10 out |
| Tuesday, July 21 |
| » Lost to Athletics (35-58), 5-4 | Metropolitan Stadium (21-23) | 47-46 | Lost 6 |
| » Starters: Jose Santiago vs Camilo Pascual | Fifth | 9½ out |
| Wednesday, July 22 |
| » Lost to Athletics (36-58), 6-4 | Metropolitan Stadium (21-24) | 47-47 | Lost 7 |
| » Starters: Orlando Pena vs Dick Stigman | Fifth | 10½ out |
| Thursday, July 23 |
| » Lost to Athletics (37-58), 4-3 | Metropolitan Stadium (21-25) | 47-48 | Lost 8 |
| » Starters: Diego Segui vs Jim Kaat | Fifth | 10½ out |
| Friday, July 24 |
| » Defeated White Sox (56-38), 6-3 | Comiskey Park I (1-1) | 48-48 | |
| » Starters: Mudcat Grant vs Juan Pizarro | Fourth | 11 out |
| Saturday, July 25 |
| » Lost to White Sox (57-38), 6-5 | Comiskey Park I (1-2) | 48-49 | |
| » Starters: Jim Roland vs Fred Talbot | Fifth | 12 out |
| Sunday, July 26 |
| » Lost to White Sox (58-38), 5-4 | Comiskey Park I (1-3) | 48-50 | Lost 2 |
| » Starters: Camilo Pascual vs Gary Peters | Sixth | 13 out |
| » Lost to White Sox (59-38), 3-0 | Comiskey Park I (1-4) | 48-51 | Lost 3 |
| » Starters: Dick Stigman vs John Buzhardt | Sixth | 13 out |
| Monday, July 27 |
| » Major-league debuts: Dave Eilers (Braves) |
| Tuesday, July 28 |
| » Defeated Orioles (60-39), 7-4 | Metropolitan Stadium (22-25) | 49-51 | |
| » Starters: Robin Roberts vs Jim Kaat | Fifth | 12½ out |
| Wednesday, July 29 |
| » Lost to Orioles (61-39), 4-3 | Metropolitan Stadium (22-26) | 49-52 | |
| » Starters: Milt Pappas vs Mudcat Grant | Seventh | 13½ out |
| Thursday, July 30 |
| » Lost to Orioles (62-39), 7-4 | Metropolitan Stadium (22-27) | 49-53 | Lost 2 |
| » Starters: Dave Vineyard vs Gerry Arrigo | Seventh | 14 out |
| Friday, July 31 |
| » Defeated Yankees (61-38), 4-3 | Metropolitan Stadium (23-27) | 50-53 | |
| » Starters: Al Downing vs Camilo Pascual | Sixth | 13 out |
| Saturday, August 1 |
| » Lost to Yankees (62-38), 6-4 | Metropolitan Stadium (23-28) | 50-54 | |
| » Starters: Ralph Terry vs Dick Stigman | Sixth | 14 out |
| Sunday, August 2 |
| » Lost to Yankees (63-38), 2-0 | Metropolitan Stadium (23-29) | 50-55 | Lost 2 |
| » Starters: Jim Bouton vs Jim Kaat | Sixth | 15 out |
| Tuesday, August 4 |
| » Defeated Red Sox (52-55), 12-4 | Metropolitan Stadium (24-29) | 51-55 | |
| » Starters: Bill Monbouquette vs Mudcat Grant | Sixth | 14 out |
| » Major-league debuts: Jay Ritchie (Red Sox) |
| Wednesday, August 5 |
| » Defeated Red Sox (52-56), 6-1 | Metropolitan Stadium (25-29) | 52-55 | Won 2 |
| » Starters: Earl Wilson vs Camilo Pascual | Fifth | 13 out |
| Thursday, August 6 |
| » Defeated Red Sox (52-57), 6-5 | Metropolitan Stadium (26-29) | 53-55 | Won 3 |
| » Starters: Bob Heffner vs Jim Roland | Fifth | 13 out |
| Friday, August 7 |
| » Lost to Indians (50-59), 10-4 | Cleveland Stadium (1-4) | 53-56 | |
| » Starters: Dick Stigman vs Luis Tiant | Sixth | 14½ out |
| » Lost to Indians (51-59), 8-2 | Cleveland Stadium (1-5) | 53-57 | Lost 2 |
| » Starters: Jim Kaat vs Sam McDowell | Sixth | 14½ out |
| Saturday, August 8 |
| » Lost to Indians (52-59), 16-8 | Cleveland Stadium (1-6) | 53-58 | Lost 3 |
| » Starters: Mudcat Grant vs Dick Donovan | Sixth | 15½ out |
| Sunday, August 9 |
| » Lost to Indians (53-59), 7-0 | Cleveland Stadium (1-7) | 53-59 | Lost 4 |
| » Starters: Camilo Pascual vs Sonny Siebert | Sixth | 15½ out |
| » Defeated Indians (53-60), 3-1 | Cleveland Stadium (2-7) | 54-59 | |
| » Starters: Jim Kaat vs Lee Stange | Sixth | 15½ out |
| Tuesday, August 11 |
| » Defeated Tigers (58-58), 5-3 | Metropolitan Stadium (27-29) | 55-59 | Won 2 |
| » Starters: Hank Aguirre vs Dick Stigman | Sixth | 15½ out |
| Wednesday, August 12 |
| » Lost to Tigers (59-58), 6-2 | Metropolitan Stadium (27-30) | 55-60 | |
| » Starters: Mickey Lolich vs Mudcat Grant | Sixth | 16½ out |
| Thursday, August 13 |
| » Defeated Tigers (59-59), 6-3 | Metropolitan Stadium (28-30) | 56-60 | |
| » Starters: Dave Wickersham vs Camilo Pascual | Sixth | 16½ out |
| Future Twin Tom Prince is born in Kankakee, IL. |
| Friday, August 14 |
| » Defeated Indians (54-62), 7-6 | Metropolitan Stadium (29-30) | 57-60 | Won 2 |
| » Starters: Lee Stange vs Jim Kaat | Sixth | 16½ out |
| Saturday, August 15 |
| » Defeated Indians (54-63), 9-3 | Metropolitan Stadium (30-30) | 58-60 | Won 3 |
| » Starters: Luis Tiant vs Dick Stigman | Sixth | 15½ out |
| Sunday, August 16 |
| » Defeated Indians (54-64), 13-2 | Metropolitan Stadium (31-30) | 59-60 | Won 4 |
| » Starters: Sonny Siebert vs Mudcat Grant | Fifth | 14½ out |
| Future Twin Rick Reed is born in Huntington, WV. |
| Tuesday, August 18 |
| » Defeated Senators (49-74), 6-1 | Robert F. Kennedy Stadium (6-2) | 60-60 | Won 5 |
| » Starters: Camilo Pascual vs Steve Ridzik | Fifth | 14½ out |
| Wednesday, August 19 |
| » Defeated Senators (49-75), 3-1 | Robert F. Kennedy Stadium (7-2) | 61-60 | Won 6 |
| » Starters: Jim Kaat vs Dave Stenhouse | Fifth | 13½ out |
| Friday, August 21 |
| » Lost to Tigers (64-62), 4-1 | Tiger Stadium (2-5) | 61-61 | |
| » Starters: Dick Stigman vs Dave Wickersham | Sixth | 14 out |
| Sunday, August 23 |
| » Defeated Tigers (64-63), 6-5 | Tiger Stadium (3-5) | 62-61 | |
| » Starters: Camilo Pascual vs Mickey Lolich | Fifth | 14½ out |
| » Lost to Tigers (65-63), 5-2 | Tiger Stadium (3-6) | 62-62 | |
| » Starters: Mudcat Grant vs Hank Aguirre | Fifth | 14½ out |
| Monday, August 24 |
| » Defeated White Sox (76-51), 4-3 | Comiskey Park I (2-4) | 63-62 | |
| » Starters: Jim Kaat vs John Buzhardt | Fifth | 14 out |
| Tuesday, August 25 |
| » Lost to White Sox (77-51), 1-0 | Comiskey Park I (2-5) | 63-63 | |
| » Starters: Dick Stigman vs Juan Pizarro | Fifth | 14 out |
| Wednesday, August 26 |
| » Lost to White Sox (78-51), 2-1 | Comiskey Park I (2-6) | 63-64 | Lost 2 |
| » Starters: Camilo Pascual vs Joe Horlen | Fifth | 14 out |
| Thursday, August 27 |
| » Defeated White Sox (78-52), 5-2 | Comiskey Park I (3-6) | 64-64 | |
| » Starters: Mudcat Grant vs Ray Herbert | Fifth | 13½ out |
| Friday, August 28 |
| » Lost to Senators (52-79), 3-1 | Metropolitan Stadium (31-31) | 64-65 | |
| » Starters: Frank Kreutzer vs Jim Kaat | Fifth | 14 out |
| Saturday, August 29 |
| » Lost to Senators (53-79), 5-4 | Metropolitan Stadium (31-32) | 64-66 | Lost 2 |
| » Starters: Steve Ridzik vs Dick Stigman | Sixth | 15 out |
| Sunday, August 30 |
| » Defeated Senators (53-80), 5-4 | Metropolitan Stadium (32-32) | 65-66 | |
| » Starters: Claude Osteen vs Camilo Pascual | Sixth | 14 out |
| Monday, August 31 |
| » Defeated Senators (53-81), 2-1 | Metropolitan Stadium (33-32) | 66-66 | Won 2 |
| » Starters: Buster Narum vs Mudcat Grant | Fifth | 13½ out |
| Tuesday, September 1 |
| » Defeated Orioles (79-53), 2-1 | Metropolitan Stadium (34-32) | 67-66 | Won 3 |
| » Starters: Steve Barber vs Jim Kaat | Fifth | 12½ out |
| Future Twin David West is born in Memphis, TN. |
| Wednesday, September 2 |
| » Lost to Orioles (80-53), 2-0 | Metropolitan Stadium (34-33) | 67-67 | |
| » Starters: Milt Pappas vs Dick Stigman | Fifth | 13½ out |
| Thursday, September 3 |
| » Lost to Orioles (81-53), 4-1 | Metropolitan Stadium (34-34) | 67-68 | Lost 2 |
| » Starters: Wally Bunker vs Camilo Pascual | Seventh | 14½ out |
| Friday, September 4 |
| » Defeated Red Sox (61-76), 14-3 | Metropolitan Stadium (35-34) | 68-68 | |
| » Starters: Bob Heffner vs Mudcat Grant | Sixth | 13½ out |
| » Major-league debuts: Rich Reese (Twins) |
| Saturday, September 5 |
| » Defeated Red Sox (61-77), 10-4 | Metropolitan Stadium (36-34) | 69-68 | Won 2 |
| » Starters: Jack Lamabe vs Jim Kaat | Sixth | 13½ out |
| Sunday, September 6 |
| » Defeated Red Sox (61-78), 2-1 | Metropolitan Stadium (37-34) | 70-68 | Won 3 |
| » Starters: Bill Monbouquette vs Gerry Arrigo | Sixth | 13 out |
| Monday, September 7 |
| » Lost to Yankees (80-56), 5-4 | Metropolitan Stadium (37-35) | 70-69 | |
| » Starters: Jim Bouton vs Dick Stigman | Sixth | 13 out |
| Tuesday, September 8 |
| » Lost to Yankees (81-56), 2-1 | Metropolitan Stadium (37-36) | 70-70 | Lost 2 |
| » Starters: Mel Stottlemyre vs Camilo Pascual | Sixth | 13½ out |
| Wednesday, September 9 |
| » Defeated White Sox (84-59), 5-2 | Metropolitan Stadium (38-36) | 71-70 | |
| » Starters: Juan Pizarro vs Mudcat Grant | Sixth | 13 out |
| Thursday, September 10 |
| » Lost to White Sox (85-59), 2-1 | Metropolitan Stadium (38-37) | 71-71 | |
| » Starters: Joe Horlen vs Jim Kaat | Sixth | 14 out |
| Friday, September 11 |
| » Defeated Yankees (82-58), 5-3 | Yankee Stadium (5-2) | 72-71 | |
| » Starters: Gerry Arrigo vs Jim Bouton | Sixth | 13½ out |
| » Major-league debuts: Roger Repoz (Yankees) |
| Saturday, September 12 |
| » Lost to Yankees (83-58), 4-3 | Yankee Stadium (5-3) | 72-72 | |
| » Starters: Camilo Pascual vs Mel Stottlemyre | Sixth | 14½ out |
| Sunday, September 13 |
| » Lost to Yankees (84-58), 5-2 | Yankee Stadium (5-4) | 72-73 | Lost 2 |
| » Starters: Dick Stigman vs Whitey Ford | Seventh | 14½ out |
| » Major-league debuts: Mike Hegan (Yankees) |
| Monday, September 14 |
| » Lost to Orioles (88-59), 4-3 | Memorial Stadium (2-5) | 72-74 | Lost 3 |
| » Starters: Mudcat Grant vs Milt Pappas | Seventh | 15½ out |
| Tuesday, September 15 |
| » Defeated Orioles (88-60), 2-1 | Memorial Stadium (3-5) | 73-74 | |
| » Starters: Jim Kaat vs Robin Roberts | Seventh | 14½ out |
| Wednesday, September 16 |
| » Defeated Orioles (88-61), 2-1 | Memorial Stadium (4-5) | 74-74 | Won 2 |
| » Starters: Camilo Pascual vs Wally Bunker | Sixth | 13½ out |
| Friday, September 18 |
| » Lost to Red Sox (67-83), 7-6 | Fenway Park (4-3) | 74-75 | |
| » Starters: Dave Boswell vs Pete Charton | Seventh | 14½ out |
| » Major-league debuts: Dave Boswell (Twins) |
| Saturday, September 19 |
| » Lost to Red Sox (68-83), 7-2 | Fenway Park (4-4) | 74-76 | Lost 2 |
| » Starters: Mudcat Grant vs Earl Wilson | Seventh | 15½ out |
| Sunday, September 20 |
| » Defeated Red Sox (68-84), 12-4 | Fenway Park (5-4) | 75-76 | |
| » Starters: Jim Kaat vs Ed Connolly | Seventh | 15½ out |
| Tuesday, September 22 |
| » Lost to Athletics (55-96), 10-9 | Municipal Stadium (5-3) | 75-77 | |
| » Starters: Camilo Pascual vs Blue Moon Odom | Seventh | 17 out |
| Wednesday, September 23 |
| » Defeated Athletics (55-97), 2-1 | Municipal Stadium (6-3) | 76-77 | |
| » Starters: Dave Boswell vs Lew Krausse | Fifth | 17½ out |
| Friday, September 25 |
| » Lost to Angels (79-77), 1-0 | Dodger Stadium (3-4) | 76-78 | |
| » Starters: Jim Kaat vs Dean Chance | Fifth | 18½ out |
| Saturday, September 26 |
| » Lost to Angels (80-77), 2-0 | Dodger Stadium (3-5) | 76-79 | Lost 2 |
| » Starters: Mudcat Grant vs Bill Kelso | Fifth | 19½ out |
| Sunday, September 27 |
| » Defeated Angels (80-78), 3-1 | Dodger Stadium (4-5) | 77-79 | |
| » Starters: Camilo Pascual vs Fred Newman | Fifth | 18½ out |
| Tuesday, September 29 |
| » Lost to Athletics (56-100), 7-6 | Metropolitan Stadium (38-38) | 77-80 | |
| » Starters: Lew Krausse vs Dave Boswell | Sixth | |
