| Thursday, February 27 |
| Former Senator Tony Smith dies in Galveston, TX at the age of 80. |
| Wednesday, April 8 |
| Former Senator Mickey O'Neil dies in St.Louis, MO at the age of 64. |
| Monday, April 13 |
| » Lost to Angels (1-0), 4-0 | Robert F. Kennedy Stadium (0-1) | 0-1 | |
| » Starters: Ken McBride vs Claude Osteen | Third | 1 out |
| » Major-league debuts: Bobby Knoop (Angels) |
| Wednesday, April 15 |
| » Defeated Angels (1-1), 6-4 | Robert F. Kennedy Stadium (1-1) | 1-1 | |
| » Starters: Barry Latman vs Bennie Daniels | Third | ½ out |
| Thursday, April 16 |
| » Lost to Twins (2-0), 6-2 | Robert F. Kennedy Stadium (1-2) | 1-2 | |
| » Starters: Jim Kaat vs Carl Bouldin | Fourth | 1½ out |
| Friday, April 17 |
| » Defeated Twins (2-1), 4-3 | Robert F. Kennedy Stadium (2-2) | 2-2 | |
| » Starters: Lee Stange vs Tom Cheney | Fifth | 1½ out |
| Saturday, April 18 |
| » Lost to Twins (3-1), 8-6 | Robert F. Kennedy Stadium (2-3) | 2-3 | |
| » Starters: Dick Stigman vs Dave Stenhouse | Sixth | 2½ out |
| » Major-league debuts: Mike Brumley (Senators) Joe Nossek (Twins) |
| Sunday, April 19 |
| » Lost to Athletics (1-2), 5-1 | Robert F. Kennedy Stadium (2-4) | 2-4 | Lost 2 |
| » Starters: Orlando Pena vs Claude Osteen | Eighth | 2½ out |
| Tuesday, April 21 |
| » Major-league debuts: Walt Williams (Astros) Bobby Klaus (Reds) |
| Wednesday, April 22 |
| » Lost to Twins (5-2), 7-6 | Metropolitan Stadium (0-1) | 2-5 | Lost 3 |
| » Starters: Howie Koplitz vs Jim Kaat | Eighth | 3 out |
| Thursday, April 23 |
| » Defeated Twins (5-3), 5-4 | Metropolitan Stadium (1-1) | 3-5 | |
| » Starters: Carl Bouldin vs Lee Stange | Sixth | 2 out |
| Friday, April 24 |
| » Defeated Athletics (1-4), 6-1 | Municipal Stadium (1-0) | 4-5 | Won 2 |
| » Starters: Claude Osteen vs Orlando Pena | Sixth | 2 out |
| Saturday, April 25 |
| » Lost to Athletics (2-4), 3-1 | Municipal Stadium (1-1) | 4-6 | |
| » Starters: Tom Cheney vs Moe Drabowsky | Eighth | 3 out |
| Sunday, April 26 |
| » Defeated Athletics (2-5), 7-4 | Municipal Stadium (2-1) | 5-6 | |
| » Starters: Bennie Daniels vs Lew Krausse | Sixth | 2 out |
| Monday, April 27 |
| » Defeated Angels (4-7), 6-3 | Dodger Stadium (1-0) | 6-6 | Won 2 |
| » Starters: Buster Narum vs Ken McBride | Sixth | 2½ out |
| Tuesday, April 28 |
| » Lost to Angels (5-7), 2-1 | Dodger Stadium (1-1) | 6-7 | |
| » Starters: Claude Osteen vs Barry Latman | Seventh | 2½ out |
| Wednesday, April 29 |
| » Lost to Angels (6-7), 5-1 | Dodger Stadium (1-2) | 6-8 | Lost 2 |
| » Starters: Carl Bouldin vs Bob Lee | Seventh | 3 out |
| Friday, May 1 |
| » Lost to Yankees (5-4), 1-0 | Yankee Stadium (0-1) | 6-9 | Lost 3 |
| » Starters: Bennie Daniels vs Whitey Ford | Eighth | 3 out |
| Saturday, May 2 |
| » Defeated Yankees (5-5), 5-4 | Yankee Stadium (1-1) | 7-9 | |
| » Starters: Claude Osteen vs Jim Bouton | Seventh | 3 out |
| Sunday, May 3 |
| » Lost to Yankees (6-5), 4-0 | Yankee Stadium (1-2) | 7-10 | |
| » Starters: Dave Stenhouse vs Al Downing | Seventh | 3 out |
| » Defeated Yankees (6-6), 6-5 | Yankee Stadium (2-2) | 8-10 | |
| » Starters: Buster Narum vs Ralph Terry | Seventh | 3 out |
| Monday, May 4 |
| » Lost to Orioles (8-7), 11-4 | Memorial Stadium (0-1) | 8-11 | |
| » Starters: Tom Cheney vs Chuck Estrada | Seventh | 4 out |
| Tuesday, May 5 |
| » Lost to Orioles (9-7), 2-1 | Memorial Stadium (0-2) | 8-12 | Lost 2 |
| » Starters: Jim Hannan vs Wally Bunker | Ninth | 4 out |
| Wednesday, May 6 |
| » Lost to Yankees (8-6), 9-2 | Robert F. Kennedy Stadium (2-5) | 8-13 | Lost 3 |
| » Starters: Jim Bouton vs Bennie Daniels | Sixth | 4½ out |
| » Defeated Yankees (8-7), 5-4 | Robert F. Kennedy Stadium (3-5) | 9-13 | |
| » Starters: Stan Williams vs Claude Osteen | Sixth | 4½ out |
| Thursday, May 7 |
| » Lost to Yankees (9-7), 9-6 | Robert F. Kennedy Stadium (3-6) | 9-14 | |
| » Starters: Al Downing vs Dave Stenhouse | Eighth | 5½ out |
| Friday, May 8 |
| » Lost to Red Sox (9-10), 9-3 | Robert F. Kennedy Stadium (3-7) | 9-15 | Lost 2 |
| » Starters: Bill Spanswick vs Buster Narum | Ninth | 6 out |
| Saturday, May 9 |
| » Defeated Red Sox (9-11), 5-4 | Robert F. Kennedy Stadium (4-7) | 10-15 | |
| » Starters: Dave Morehead vs Tom Cheney | Eighth | 5 out |
| Sunday, May 10 |
| » Defeated Red Sox (9-12), 13-4 | Robert F. Kennedy Stadium (5-7) | 11-15 | Won 2 |
| » Starters: Bill Monbouquette vs Claude Osteen | Ninth | 5½ out |
| » Lost to Red Sox (10-12), 9-4 | Robert F. Kennedy Stadium (5-8) | 11-16 | |
| » Starters: Earl Wilson vs Jim Hannan | Ninth | 5½ out |
| Monday, May 11 |
| » Defeated Orioles (13-10), 6-4 | Robert F. Kennedy Stadium (6-8) | 12-16 | |
| » Starters: Mike McCormick vs Bennie Daniels | Eighth | 5 out |
| Tuesday, May 12 |
| » Lost to Orioles (14-10), 5-0 | Robert F. Kennedy Stadium (6-9) | 12-17 | |
| » Starters: Dave McNally vs Dave Stenhouse | Ninth | 5 out |
| Thursday, May 14 |
| » Defeated Orioles (14-11), 4-1 | Robert F. Kennedy Stadium (7-9) | 13-17 | |
| » Starters: Robin Roberts vs Buster Narum | Eighth | 4½ out |
| Former Senator Dave Altizer dies in Pleasant Hill, IL at the age of 88. |
| Friday, May 15 |
| » Lost to White Sox (14-8), 2-0 | Robert F. Kennedy Stadium (7-10) | 13-18 | |
| » Starters: John Buzhardt vs Claude Osteen | Eighth | 5½ out |
| Former Senator Harley Boss dies in Nashville, TN at the age of 56. |
| Saturday, May 16 |
| » Defeated White Sox (14-9), 3-1 | Robert F. Kennedy Stadium (8-10) | 14-18 | |
| » Starters: Ray Herbert vs Bennie Daniels | Sixth | 5½ out |
| Sunday, May 17 |
| » Lost to White Sox (15-9), 3-2 | Robert F. Kennedy Stadium (8-11) | 14-19 | |
| » Starters: Juan Pizarro vs Alan Koch | Seventh | 5½ out |
| Monday, May 18 |
| » Lost to Tigers (14-15), 7-6 | Robert F. Kennedy Stadium (8-12) | 14-20 | Lost 2 |
| » Starters: Frank Lary vs Jim Hannan | Ninth | 6 out |
| Tuesday, May 19 |
| » Lost to Tigers (15-15), 5-2 | Robert F. Kennedy Stadium (8-13) | 14-21 | Lost 3 |
| » Starters: Dave Wickersham vs Buster Narum | Ninth | 7 out |
| Wednesday, May 20 |
| » Defeated Tigers (15-16), 10-3 | Robert F. Kennedy Stadium (9-13) | 15-21 | |
| » Starters: Ed Rakow vs Claude Osteen | Seventh | 6½ out |
| » Major-league debuts: Joe Sparma (Tigers) |
| Thursday, May 21 |
| » Defeated Tigers (15-17), 8-2 | Robert F. Kennedy Stadium (10-13) | 16-21 | Won 2 |
| » Starters: Jack Hamilton vs Bennie Daniels | Sixth | 6 out |
| Friday, May 22 |
| » Lost to White Sox (17-9), 3-1 | Comiskey Park I (0-1) | 16-22 | |
| » Starters: Alan Koch vs Juan Pizarro | Sixth | 7 out |
| Saturday, May 23 |
| » Lost to White Sox (18-9), 14-2 | Comiskey Park I (0-2) | 16-23 | Lost 2 |
| » Starters: Jim Hannan vs John Buzhardt | Eighth | 8 out |
| Sunday, May 24 |
| » Lost to White Sox (19-9), 6-4 | Comiskey Park I (0-3) | 16-24 | Lost 3 |
| » Starters: Claude Osteen vs Ray Herbert | Eighth | 8 out |
| » Defeated White Sox (19-10), 3-0 | Comiskey Park I (1-3) | 17-24 | |
| » Starters: Buster Narum vs Joe Horlen | Eighth | 8 out |
| Monday, May 25 |
| » Lost to Red Sox (19-18), 6-5 | Fenway Park (0-1) | 17-25 | |
| » Starters: Jim Duckworth vs Dave Morehead | Eighth | 9 out |
| Tuesday, May 26 |
| » Lost to Red Sox (20-18), 3-2 | Fenway Park (0-2) | 17-26 | Lost 2 |
| » Starters: Bennie Daniels vs Earl Wilson | Eighth | 9½ out |
| Wednesday, May 27 |
| » Defeated Red Sox (20-19), 9-8 | Fenway Park (1-2) | 18-26 | |
| » Starters: Alan Koch vs Bill Monbouquette | Eighth | 9 out |
| Friday, May 29 |
| » Defeated Indians (18-16), 8-4 | Robert F. Kennedy Stadium (11-13) | 19-26 | Won 2 |
| » Starters: Tommy John vs Claude Osteen | Eighth | 8½ out |
| Saturday, May 30 |
| » Lost to Indians (19-16), 10-2 | Robert F. Kennedy Stadium (11-14) | 19-27 | |
| » Starters: Pedro Ramos vs Buster Narum | Eighth | 9½ out |
| Sunday, May 31 |
| » Lost to Indians (20-16), 9-6 | Robert F. Kennedy Stadium (11-15) | 19-28 | Lost 2 |
| » Starters: Mudcat Grant vs Don Rudolph | Seventh | 11½ out |
| » Lost to Indians (21-16), 8-3 | Robert F. Kennedy Stadium (11-16) | 19-29 | Lost 3 |
| » Starters: Gary Bell vs Bennie Daniels | Seventh | 11½ out |
| Wednesday, June 3 |
| » Defeated Tigers (18-25), 6-2 | Tiger Stadium (1-0) | 20-29 | |
| » Starters: Claude Osteen vs Dave Wickersham | Eighth | 12 out |
| Friday, June 5 |
| » Defeated Indians (23-19), 5-3 | Cleveland Stadium (1-0) | 21-29 | Won 2 |
| » Starters: Buster Narum vs Pedro Ramos | Sixth | 11 out |
| Saturday, June 6 |
| » Lost to Indians (24-19), 6-4 | Cleveland Stadium (1-1) | 21-30 | |
| » Starters: Bennie Daniels vs Jack Kralick | Seventh | 12 out |
| Sunday, June 7 |
| » Lost to Indians (25-19), 3-2 | Cleveland Stadium (1-2) | 21-31 | Lost 2 |
| » Starters: Don Rudolph vs Sam McDowell | Seventh | 12 out |
| » Defeated Indians (25-20), 6-3 | Cleveland Stadium (2-2) | 22-31 | |
| » Starters: Alan Koch vs Gary Bell | Seventh | 12 out |
| Monday, June 8 |
| » Lost to Athletics (17-32), 5-4 | Robert F. Kennedy Stadium (11-17) | 22-32 | |
| » Starters: Moe Drabowsky vs Claude Osteen | Eighth | 12½ out |
| Tuesday, June 9 |
| » Defeated Athletics (17-33), 8-4 | Robert F. Kennedy Stadium (12-17) | 23-32 | |
| » Starters: John O'Donoghue vs Buster Narum | Eighth | 12 out |
| » Defeated Athletics (17-34), 5-1 | Robert F. Kennedy Stadium (13-17) | 24-32 | Won 2 |
| » Starters: Dan Pfister vs Tom Cheney | Eighth | 12 out |
| Wednesday, June 10 |
| » Defeated Athletics (17-35), 3-1 | Robert F. Kennedy Stadium (14-17) | 25-32 | Won 3 |
| » Starters: Ted Bowsfield vs Bennie Daniels | Eighth | 12 out |
| Friday, June 12 |
| » Lost to Twins (30-25), 5-3 | Robert F. Kennedy Stadium (14-18) | 25-33 | |
| » Starters: Camilo Pascual vs Alan Koch | Eighth | 11 out |
| Saturday, June 13 |
| » Defeated Twins (30-26), 4-2 | Robert F. Kennedy Stadium (15-18) | 26-33 | |
| » Starters: Jim Roland vs Claude Osteen | Eighth | 10 out |
| Sunday, June 14 |
| » Lost to Twins (31-26), 6-5 | Robert F. Kennedy Stadium (15-19) | 26-34 | |
| » Starters: Lee Stange vs Buster Narum | Eighth | 11 out |
| » Lost to Twins (32-26), 9-2 | Robert F. Kennedy Stadium (15-20) | 26-35 | Lost 2 |
| » Starters: Jim Kaat vs Tom Cheney | Eighth | 11 out |
| Monday, June 15 |
| » Defeated Angels (24-37), 3-2 | Robert F. Kennedy Stadium (16-20) | 27-35 | |
| » Starters: Dean Chance vs Don Rudolph | Eighth | 10 out |
| Tuesday, June 16 |
| » Lost to Angels (25-37), 7-5 | Robert F. Kennedy Stadium (16-21) | 27-36 | |
| » Starters: Bob Meyer vs Bennie Daniels | Eighth | 10½ out |
| Wednesday, June 17 |
| » Lost to Angels (26-37), 5-3 | Robert F. Kennedy Stadium (16-22) | 27-37 | Lost 2 |
| » Starters: Bo Belinsky vs Buster Narum | Eighth | 11½ out |
| Friday, June 19 |
| » Lost to Athletics (24-37), 5-4 | Municipal Stadium (2-2) | 27-38 | Lost 3 |
| » Starters: Bennie Daniels vs Moe Drabowsky | Ninth | 12½ out |
| Saturday, June 20 |
| » Lost to Athletics (25-37), 8-2 | Municipal Stadium (2-3) | 27-39 | Lost 4 |
| » Starters: Jim Hannan vs Diego Segui | Ninth | 13½ out |
| Sunday, June 21 |
| » Defeated Athletics (25-38), 13-2 | Municipal Stadium (3-3) | 28-39 | |
| » Starters: Buster Narum vs Orlando Pena | Ninth | 12 out |
| » Defeated Athletics (25-39), 5-2 | Municipal Stadium (4-3) | 29-39 | Won 2 |
| » Starters: Alan Koch vs Ted Bowsfield | Ninth | 12 out |
| Monday, June 22 |
| » Lost to Angels (30-37), 5-2 | Dodger Stadium (1-3) | 29-40 | |
| » Starters: Don Rudolph vs Barry Latman | Ninth | 13 out |
| Tuesday, June 23 |
| » Lost to Angels (31-37), 2-0 | Dodger Stadium (1-4) | 29-41 | Lost 2 |
| » Starters: Bennie Daniels vs Dean Chance | Ninth | 13½ out |
| Wednesday, June 24 |
| » Lost to Angels (32-37), 9-5 | Dodger Stadium (1-5) | 29-42 | Lost 3 |
| » Starters: Claude Osteen vs Ken McBride | Ninth | 14½ out |
| Friday, June 26 |
| » Lost to Orioles (43-25), 9-4 | Robert F. Kennedy Stadium (16-23) | 29-43 | Lost 4 |
| » Starters: Dave McNally vs Buster Narum | Ninth | 16 out |
| Saturday, June 27 |
| » Lost to Orioles (44-25), 3-1 | Robert F. Kennedy Stadium (16-24) | 29-44 | Lost 5 |
| » Starters: Milt Pappas vs Jim Hannan | Ninth | 17 out |
| Sunday, June 28 |
| » Lost to Orioles (45-25), 6-4 | Robert F. Kennedy Stadium (16-25) | 29-45 | Lost 6 |
| » Starters: Wally Bunker vs Alan Koch | Ninth | 18 out |
| Monday, June 29 |
| » Defeated Tigers (32-37), 5-3 | Robert F. Kennedy Stadium (17-25) | 30-45 | |
| » Starters: Phil Regan vs Claude Osteen | Ninth | 18 out |
| Tuesday, June 30 |
| » Defeated Tigers (32-38), 6-5 | Robert F. Kennedy Stadium (18-25) | 31-45 | Won 2 |
| » Starters: Dave Wickersham vs Jim Hannan | Ninth | 17 out |
| Wednesday, July 1 |
| » Lost to White Sox (40-29), 8-7 | Comiskey Park I (1-4) | 31-46 | |
| » Starters: Buster Narum vs John Buzhardt | Ninth | 18½ out |
| » Lost to White Sox (41-29), 2-1 | Comiskey Park I (1-5) | 31-47 | Lost 2 |
| » Starters: Don Rudolph vs Joe Horlen | Ninth | 18½ out |
| Friday, July 3 |
| » Defeated Tigers (34-39), 3-1 | Tiger Stadium (2-0) | 32-47 | |
| » Starters: Bennie Daniels vs Ed Rakow | Ninth | 18½ out |
| » Lost to Tigers (35-39), 2-1 | Tiger Stadium (2-1) | 32-48 | |
| » Starters: Dave Stenhouse vs Phil Regan | Ninth | 18½ out |
| Saturday, July 4 |
| » Lost to Tigers (36-39), 5-3 | Tiger Stadium (2-2) | 32-49 | Lost 2 |
| » Starters: Claude Osteen vs Dave Wickersham | Ninth | 19 out |
| Sunday, July 5 |
| » Lost to Tigers (37-39), 7-6 | Tiger Stadium (2-3) | 32-50 | Lost 3 |
| » Starters: Buster Narum vs Denny McLain | Tenth | 19½ out |
| » Lost to Tigers (38-39), 3-0 | Tiger Stadium (2-4) | 32-51 | Lost 4 |
| » Starters: Alan Koch vs Joe Sparma | Tenth | 19½ out |
| Thursday, July 9 |
| » Lost to Yankees (46-31), 6-5 | Robert F. Kennedy Stadium (18-26) | 32-52 | Lost 5 |
| » Starters: Al Downing vs Claude Osteen | Tenth | 21 out |
| Friday, July 10 |
| » Lost to Yankees (47-31), 4-1 | Robert F. Kennedy Stadium (18-27) | 32-53 | Lost 6 |
| » Starters: Whitey Ford vs Buster Narum | Tenth | 21 out |
| Saturday, July 11 |
| » Lost to Yankees (48-31), 3-2 | Robert F. Kennedy Stadium (18-28) | 32-54 | Lost 7 |
| » Starters: Jim Bouton vs Dave Stenhouse | Tenth | 22 out |
| Sunday, July 12 |
| » Lost to Red Sox (40-44), 5-3 | Robert F. Kennedy Stadium (18-29) | 32-55 | Lost 8 |
| » Starters: Jack Lamabe vs Bennie Daniels | Ninth | 22 out |
| » Defeated Red Sox (40-45), 10-3 | Robert F. Kennedy Stadium (19-29) | 33-55 | |
| » Starters: Dave Morehead vs Alan Koch | Ninth | 22 out |
| Monday, July 13 |
| » Lost to Red Sox (41-45), 7-0 | Robert F. Kennedy Stadium (19-30) | 33-56 | |
| » Starters: Bill Monbouquette vs Jim Duckworth | Tenth | 22 out |
| Tuesday, July 14 |
| » Defeated Twins (46-40), 4-3 | Metropolitan Stadium (2-1) | 34-56 | |
| » Starters: Claude Osteen vs Jim Kaat | Ninth | 21 out |
| Wednesday, July 15 |
| » Lost to Twins (47-40), 6-0 | Metropolitan Stadium (2-2) | 34-57 | |
| » Starters: Don Rudolph vs Mudcat Grant | Tenth | 21½ out |
| Thursday, July 16 |
| » Defeated Twins (47-41), 7-2 | Metropolitan Stadium (3-2) | 35-57 | |
| » Starters: Dave Stenhouse vs Camilo Pascual | Tenth | 21 out |
| Friday, July 17 |
| » Lost to Red Sox (43-47), 5-0 | Fenway Park (1-3) | 35-58 | |
| » Starters: Alan Koch vs Bill Monbouquette | Tenth | 22 out |
| Saturday, July 18 |
| » Lost to Red Sox (44-47), 12-6 | Fenway Park (1-4) | 35-59 | Lost 2 |
| » Starters: Bennie Daniels vs Earl Wilson | Tenth | 22½ out |
| Sunday, July 19 |
| » Lost to Red Sox (45-47), 11-10 | Fenway Park (1-5) | 35-60 | Lost 3 |
| » Starters: Claude Osteen vs Dave Morehead | Ninth | 23 out |
| » Defeated Red Sox (45-48), 5-4 | Fenway Park (2-5) | 36-60 | |
| » Starters: Buster Narum vs Arnold Earley | Ninth | 23 out |
| Tuesday, July 21 |
| » Lost to Yankees (54-34), 7-1 | Yankee Stadium (2-3) | 36-61 | |
| » Starters: Dave Stenhouse vs Jim Bouton | Tenth | 22½ out |
| Wednesday, July 22 |
| » Lost to Yankees (55-34), 6-3 | Yankee Stadium (2-4) | 36-62 | Lost 2 |
| » Starters: Alan Koch vs Al Downing | Ninth | 23½ out |
| Thursday, July 23 |
| » Defeated Yankees (55-35), 2-1 | Yankee Stadium (3-4) | 37-62 | |
| » Starters: Claude Osteen vs Stan Williams | Ninth | 22½ out |
| Friday, July 24 |
| » Lost to Orioles (58-37), 2-1 | Memorial Stadium (0-3) | 37-63 | |
| » Starters: Buster Narum vs Wally Bunker | Tenth | 24½ out |
| » Lost to Orioles (59-37), 7-2 | Memorial Stadium (0-4) | 37-64 | Lost 2 |
| » Starters: Steve Ridzik vs Dave Vineyard | Tenth | 24½ out |
| Saturday, July 25 |
| » Lost to Orioles (60-37), 5-4 | Memorial Stadium (0-5) | 37-65 | Lost 3 |
| » Starters: Bennie Daniels vs Steve Barber | Tenth | 25½ out |
| Sunday, July 26 |
| » Defeated Orioles (60-38), 4-1 | Memorial Stadium (1-5) | 38-65 | |
| » Starters: Dave Stenhouse vs Dave McNally | Tenth | 25 out |
| Monday, July 27 |
| » Major-league debuts: Dave Eilers (Braves) |
| Tuesday, July 28 |
| » Defeated Indians (43-55), 4-3 | Robert F. Kennedy Stadium (20-30) | 39-65 | Won 2 |
| » Starters: Luis Tiant vs Claude Osteen | Tenth | 24½ out |
| Wednesday, July 29 |
| » Defeated Indians (43-56), 4-1 | Robert F. Kennedy Stadium (21-30) | 40-65 | Won 3 |
| » Starters: Sam McDowell vs Buster Narum | Tenth | 24½ out |
| Thursday, July 30 |
| » Defeated Indians (43-57), 8-7 | Robert F. Kennedy Stadium (22-30) | 41-65 | Won 4 |
| » Starters: Dick Donovan vs Alan Koch | Ninth | 24 out |
| Friday, July 31 |
| » Lost to White Sox (61-40), 6-0 | Robert F. Kennedy Stadium (22-31) | 41-66 | |
| » Starters: Juan Pizarro vs Bennie Daniels | Tenth | 24 out |
| Saturday, August 1 |
| » Lost to White Sox (62-40), 9-8 | Robert F. Kennedy Stadium (22-32) | 41-67 | Lost 2 |
| » Starters: John Buzhardt vs Dave Stenhouse | Tenth | 25 out |
| Sunday, August 2 |
| » Lost to White Sox (63-40), 2-1 | Robert F. Kennedy Stadium (22-33) | 41-68 | Lost 3 |
| » Starters: Joe Horlen vs Claude Osteen | Tenth | 26½ out |
| » Lost to White Sox (64-40), 3-1 | Robert F. Kennedy Stadium (22-34) | 41-69 | Lost 4 |
| » Starters: Ray Herbert vs Buster Narum | Tenth | 26½ out |
| Monday, August 3 |
| » Lost to Indians (48-58), 4-2 | Cleveland Stadium (2-3) | 41-70 | Lost 5 |
| » Starters: Frank Kreutzer vs Dick Donovan | Tenth | 27 out |
| Tuesday, August 4 |
| » Defeated Indians (48-59), 4-2 | Cleveland Stadium (3-3) | 42-70 | |
| » Starters: Don Rudolph vs Pedro Ramos | Tenth | 26 out |
| Wednesday, August 5 |
| » Lost to Indians (49-59), 9-0 | Cleveland Stadium (3-4) | 42-71 | |
| » Starters: Alan Koch vs Lee Stange | Tenth | 26 out |
| Thursday, August 6 |
| Former Senator Curly Ogden dies in Upland, PA at the age of 64. |
| Friday, August 7 |
| » Defeated Angels (58-55), 4-3 | Dodger Stadium (2-5) | 43-71 | |
| » Starters: Claude Osteen vs Fred Newman | Tenth | 26½ out |
| Saturday, August 8 |
| » Lost to Angels (59-55), 3-0 | Dodger Stadium (2-6) | 43-72 | |
| » Starters: Buster Narum vs Aubrey Gatewood | Ninth | 27½ out |
| Sunday, August 9 |
| » Defeated Angels (59-56), 6-5 | Dodger Stadium (3-6) | 44-72 | |
| » Starters: Frank Kreutzer vs Dean Chance | Eighth | 27 out |
| Tuesday, August 11 |
| » Defeated Athletics (42-71), 5-2 | Municipal Stadium (5-3) | 45-72 | Won 2 |
| » Starters: Claude Osteen vs Diego Segui | Ninth | 27 out |
| Wednesday, August 12 |
| » Defeated Athletics (42-72), 4-3 | Municipal Stadium (6-3) | 46-72 | Won 3 |
| » Starters: Buster Narum vs Jose Santiago | Ninth | 27 out |
| Friday, August 14 |
| » Defeated Angels (60-58), 7-3 | Robert F. Kennedy Stadium (23-34) | 47-72 | Won 4 |
| » Starters: Aubrey Gatewood vs Dave Stenhouse | Ninth | 28 out |
| » Lost to Angels (61-58), 7-0 | Robert F. Kennedy Stadium (23-35) | 47-73 | |
| » Starters: Dean Chance vs Alan Koch | Ninth | 28 out |
| Saturday, August 15 |
| » Defeated Angels (61-59), 6-2 | Robert F. Kennedy Stadium (24-35) | 48-73 | |
| » Starters: Ken McBride vs Claude Osteen | Ninth | 27 out |
| Sunday, August 16 |
| » Defeated Angels (61-60), 4-1 | Robert F. Kennedy Stadium (25-35) | 49-73 | Won 2 |
| » Starters: Don Lee vs Buster Narum | Eighth | 26 out |
| Tuesday, August 18 |
| » Lost to Twins (60-60), 6-1 | Robert F. Kennedy Stadium (25-36) | 49-74 | |
| » Starters: Camilo Pascual vs Steve Ridzik | Eighth | 27 out |
| Wednesday, August 19 |
| » Lost to Twins (61-60), 3-1 | Robert F. Kennedy Stadium (25-37) | 49-75 | Lost 2 |
| » Starters: Jim Kaat vs Dave Stenhouse | Ninth | 27 out |
| Friday, August 21 |
| » Lost to Athletics (46-76), 3-2 | Robert F. Kennedy Stadium (25-38) | 49-76 | Lost 3 |
| » Starters: John O'Donoghue vs Claude Osteen | Ninth | 27½ out |
| Saturday, August 22 |
| » Lost to Athletics (47-76), 6-2 | Robert F. Kennedy Stadium (25-39) | 49-77 | Lost 4 |
| » Starters: Orlando Pena vs Buster Narum | Ninth | 28½ out |
| Sunday, August 23 |
| » Lost to Athletics (48-76), 3-1 | Robert F. Kennedy Stadium (25-40) | 49-78 | Lost 5 |
| » Starters: Diego Segui vs Bennie Daniels | Ninth | 28½ out |
| » Defeated Athletics (48-77), 8-5 | Robert F. Kennedy Stadium (26-40) | 50-78 | |
| » Starters: Jose Santiago vs Frank Kreutzer | Ninth | 28½ out |
| Tuesday, August 25 |
| » Lost to Yankees (72-52), 4-1 | Yankee Stadium (3-5) | 50-79 | |
| » Starters: Claude Osteen vs Whitey Ford | Ninth | 28½ out |
| Wednesday, August 26 |
| » Defeated Yankees (72-53), 2-0 | Yankee Stadium (4-5) | 51-79 | |
| » Starters: Buster Narum vs Mel Stottlemyre | Ninth | 27½ out |
| Friday, August 28 |
| » Defeated Twins (64-65), 3-1 | Metropolitan Stadium (4-2) | 52-79 | Won 2 |
| » Starters: Frank Kreutzer vs Jim Kaat | Ninth | 27 out |
| Saturday, August 29 |
| » Defeated Twins (64-66), 5-4 | Metropolitan Stadium (5-2) | 53-79 | Won 3 |
| » Starters: Steve Ridzik vs Dick Stigman | Eighth | 27 out |
| Sunday, August 30 |
| » Lost to Twins (65-66), 5-4 | Metropolitan Stadium (5-3) | 53-80 | |
| » Starters: Claude Osteen vs Camilo Pascual | Ninth | 27 out |
| Monday, August 31 |
| » Lost to Twins (66-66), 2-1 | Metropolitan Stadium (5-4) | 53-81 | Lost 2 |
| » Starters: Buster Narum vs Mudcat Grant | Ninth | 27½ out |
| Tuesday, September 1 |
| » Lost to Indians (66-67), 3-0 | Robert F. Kennedy Stadium (26-41) | 53-82 | Lost 3 |
| » Starters: Sam McDowell vs Frank Kreutzer | Ninth | 27½ out |
| Wednesday, September 2 |
| » Lost to Indians (67-67), 9-0 | Robert F. Kennedy Stadium (26-42) | 53-83 | Lost 4 |
| » Starters: Lee Stange vs Don Rudolph | Eighth | 28½ out |
| Friday, September 4 |
| » Lost to Tigers (72-66), 1-0 | Robert F. Kennedy Stadium (26-43) | 53-84 | Lost 5 |
| » Starters: Dave Wickersham vs Claude Osteen | Ninth | 29 out |
| Saturday, September 5 |
| » Lost to Tigers (73-66), 4-0 | Robert F. Kennedy Stadium (26-44) | 53-85 | Lost 6 |
| » Starters: Mickey Lolich vs Buster Narum | Ninth | 30 out |
| Sunday, September 6 |
| » Lost to Tigers (74-66), 9-3 | Robert F. Kennedy Stadium (26-45) | 53-86 | Lost 7 |
| » Starters: Hank Aguirre vs Frank Kreutzer | Ninth | 30½ out |
| Monday, September 7 |
| » Defeated White Sox (84-57), 3-0 | Robert F. Kennedy Stadium (27-45) | 54-86 | |
| » Starters: Ray Herbert vs Bennie Daniels | Ninth | 29 out |
| » Defeated White Sox (84-58), 6-2 | Robert F. Kennedy Stadium (28-45) | 55-86 | Won 2 |
| » Starters: Fred Talbot vs Dave Stenhouse | Ninth | 29 out |
| Wednesday, September 9 |
| » Lost to Orioles (84-56), 6-3 | Robert F. Kennedy Stadium (28-46) | 55-87 | |
| » Starters: Robin Roberts vs Buster Narum | Ninth | 29 out |
| » Defeated Orioles (84-57), 4-3 | Robert F. Kennedy Stadium (29-46) | 56-87 | |
| » Starters: Steve Barber vs Claude Osteen | Ninth | 29 out |
| » Major-league debuts: Paul Blair (Orioles) |
| Thursday, September 10 |
| » Lost to Orioles (85-57), 12-5 | Robert F. Kennedy Stadium (29-47) | 56-88 | |
| » Starters: Milt Pappas vs Frank Kreutzer | Ninth | 30 out |
| Friday, September 11 |
| » Lost to Tigers (76-68), 5-4 | Tiger Stadium (2-5) | 56-89 | Lost 2 |
| » Starters: Dave Stenhouse vs Dave Wickersham | Ninth | 30½ out |
| Saturday, September 12 |
| » Lost to Tigers (77-68), 6-5 | Tiger Stadium (2-6) | 56-90 | Lost 3 |
| » Starters: Bennie Daniels vs Mickey Lolich | Ninth | 31½ out |
| Sunday, September 13 |
| » Defeated Tigers (77-69), 5-1 | Tiger Stadium (3-6) | 57-90 | |
| » Starters: Claude Osteen vs Phil Regan | Ninth | 30½ out |
| Wednesday, September 16 |
| » Lost to Indians (73-72), 3-1 | Cleveland Stadium (3-5) | 57-91 | |
| » Starters: Buster Narum vs Sonny Siebert | Eighth | 31 out |
| » Lost to Indians (74-72), 3-2 | Cleveland Stadium (3-6) | 57-92 | Lost 2 |
| » Starters: Frank Kreutzer vs Sam McDowell | Eighth | 31 out |
| Friday, September 18 |
| » Defeated White Sox (88-62), 5-4 | Comiskey Park I (2-5) | 58-92 | |
| » Starters: Claude Osteen vs Juan Pizarro | Ninth | 31 out |
| Saturday, September 19 |
| » Defeated White Sox (88-63), 1-0 | Comiskey Park I (3-5) | 59-92 | Won 2 |
| » Starters: Bennie Daniels vs Joe Horlen | Ninth | 31 out |
| Sunday, September 20 |
| » Lost to White Sox (89-63), 4-3 | Comiskey Park I (3-6) | 59-93 | |
| » Starters: Buster Narum vs Gary Peters | Ninth | 32 out |
| Tuesday, September 22 |
| » Lost to Red Sox (69-84), 3-0 | Robert F. Kennedy Stadium (29-48) | 59-94 | Lost 2 |
| » Starters: Bill Monbouquette vs Claude Osteen | Ninth | 33½ out |
| Wednesday, September 23 |
| » Defeated Red Sox (69-85), 1-0 | Robert F. Kennedy Stadium (30-48) | 60-94 | |
| » Starters: Pete Charton vs Don Loun | Seventh | 34 out |
| Friday, September 25 |
| » Lost to Yankees (94-59), 6-5 | Robert F. Kennedy Stadium (30-49) | 60-95 | |
| » Starters: Jim Bouton vs Buster Narum | Seventh | 35 out |
| Saturday, September 26 |
| » Lost to Yankees (95-59), 7-0 | Robert F. Kennedy Stadium (30-50) | 60-96 | Lost 2 |
| » Starters: Mel Stottlemyre vs Claude Osteen | Seventh | 36 out |
| Former Senator Paul Zahniser dies in Klamath Falls, OR at the age of 69. |
| Sunday, September 27 |
| » Defeated Yankees (95-60), 3-2 | Robert F. Kennedy Stadium (31-50) | 61-96 | |
| » Starters: Whitey Ford vs Bennie Daniels | Eighth | 35 out |
| Wednesday, September 30 |
| » Lost to Orioles (94-64), 8-4 | Memorial Stadium (1-6) | 61-97 | |
| » Starters: Buster Narum vs Wally Bunker | Eighth | 36 out |
| » Defeated Orioles (94-65), 6-3 | Memorial Stadium (2-6) | 62-97 | |
| » Starters: Claude Osteen vs Milt Pappas | Eighth | 36 out |
| Thursday, October 1 |
| » Lost to Orioles (95-65), 2-0 | Memorial Stadium (2-7) | 62-98 | |
| » Starters: Frank Kreutzer vs Dave McNally | Eighth | 35½ out |
| Saturday, October 3 |
| » Lost to Red Sox (71-90), 7-0 | Fenway Park (2-6) | 62-99 | Lost 2 |
| » Starters: Don Loun vs Bill Monbouquette | Ninth | 37 out |
| » Major-league debuts: Mike Ryan (Red Sox) |
| Sunday, October 4 |
| » Lost to Red Sox (72-90), 14-8 | Fenway Park (2-7) | 62-100 | Lost 3 |
| » Starters: Pete Craig vs Bob Heffner | Eighth | 37 out |
Game information provided by Retrosheet (www.retrosheet.org) |