| Friday, January 3 |
| Future Red Sox Luis Rivera is born in Cidra, P.R. |
| Saturday, January 18 |
| Future Red Sox Brady Anderson is born in Silver Spring, MD. |
| Tuesday, February 25 |
| Future Red Sox Rich Rowland is born in Cloverdale, CA. |
| Monday, April 13 |
| » Major-league debuts: Bobby Knoop (Angels) |
| Tuesday, April 14 |
| » Major-league debuts: Vern Handrahan (Athletics) |
| Wednesday, April 15 |
| » Major-league debuts: Dick Kelley and Phil Niekro (Braves) |
| Thursday, April 16 |
| » Defeated Yankees (0-1), 4-3 | Yankee Stadium (1-0) | 1-0 | |
| » Starters: Bill Monbouquette vs Whitey Ford | Second | ½ out |
| » Major-league debuts: Tony Conigliaro (Red Sox) |
| Friday, April 17 |
| » Defeated White Sox (0-3), 4-1 | Fenway Park (1-0) | 2-0 | Won 2 |
| » Starters: Joe Horlen vs Jack Lamabe | Second | ½ out |
| » Major-league debuts: Dalton Jones (Red Sox) |
| Saturday, April 18 |
| » Lost to White Sox (1-3), 10-5 | Fenway Park (1-1) | 2-1 | |
| » Starters: Gary Peters vs Earl Wilson | Third | 1½ out |
| Sunday, April 19 |
| » Lost to White Sox (2-3), 6-0 | Fenway Park (1-2) | 2-2 | Lost 2 |
| » Starters: John Buzhardt vs Ed Connolly | Fifth | 1½ out |
| » Major-league debuts: Ed Connolly (Red Sox) |
| Monday, April 20 |
| » Defeated Yankees (1-4), 4-0 | Fenway Park (2-2) | 3-2 | |
| » Starters: Bob Meyer vs Bill Monbouquette | Third | 1 out |
| » Major-league debuts: Bob Meyer (Yankees) |
| Thursday, April 23 |
| » Defeated Orioles (4-2), 3-1 | Memorial Stadium (1-0) | 4-2 | Won 2 |
| » Starters: Jack Lamabe vs Steve Barber | Fourth | 1½ out |
| » Lost to Orioles (5-2), 1-0 | Memorial Stadium (1-1) | 4-3 | |
| » Starters: Dave Morehead vs Robin Roberts | Fourth | 1½ out |
| Friday, April 24 |
| » Lost to White Sox (3-4), 6-1 | Comiskey Park I (0-1) | 4-4 | Lost 2 |
| » Starters: Bill Monbouquette vs Juan Pizarro | Fifth | 1½ out |
| Saturday, April 25 |
| » Lost to White Sox (4-4), 4-2 | Comiskey Park I (0-2) | 4-5 | Lost 3 |
| » Starters: Ed Connolly vs John Buzhardt | Sixth | 2½ out |
| Sunday, April 26 |
| » Lost to White Sox (5-4), 2-1 | Comiskey Park I (0-3) | 4-6 | Lost 4 |
| » Starters: Bill Spanswick vs Fritz Ackley | Seventh | 2½ out |
| Tuesday, April 28 |
| » Defeated Orioles (5-5), 6-4 | Fenway Park (3-2) | 5-6 | |
| » Starters: Robin Roberts vs Jack Lamabe | Eighth | 1½ out |
| Wednesday, April 29 |
| » Lost to Orioles (6-5), 4-2 | Fenway Park (3-3) | 5-7 | |
| » Starters: Chuck Estrada vs Dave Morehead | Eighth | 2 out |
| Saturday, May 2 |
| » Lost to Tigers (8-6), 4-0 | Fenway Park (3-4) | 5-8 | Lost 2 |
| » Starters: Dave Wickersham vs Bill Monbouquette | Ninth | 3½ out |
| Sunday, May 3 |
| » Defeated Tigers (8-7), 11-7 | Fenway Park (4-4) | 6-8 | |
| » Starters: Phil Regan vs Jack Lamabe | Ninth | 3 out |
| Monday, May 4 |
| » Lost to Indians (9-4), 7-5 | Fenway Park (4-5) | 6-9 | |
| » Starters: Dick Donovan vs Bill Spanswick | Ninth | 4 out |
| Tuesday, May 5 |
| » Defeated Indians (9-5), 4-0 | Fenway Park (5-5) | 7-9 | |
| » Starters: Pedro Ramos vs Dave Morehead | Eighth | 3 out |
| » Major-league debuts: Tom Kelley (Indians) |
| Wednesday, May 6 |
| » Lost to Tigers (9-8), 6-3 | Tiger Stadium (0-1) | 7-10 | |
| » Starters: Bill Monbouquette vs Dave Wickersham | Fifth | 4 out |
| Thursday, May 7 |
| » Defeated Tigers (9-9), 7-3 | Tiger Stadium (1-1) | 8-10 | |
| » Starters: Jack Lamabe vs Phil Regan | Seventh | 4 out |
| Friday, May 8 |
| » Defeated Senators (9-15), 9-3 | Robert F. Kennedy Stadium (1-0) | 9-10 | Won 2 |
| » Starters: Bill Spanswick vs Buster Narum | Sixth | 3½ out |
| Saturday, May 9 |
| » Lost to Senators (10-15), 5-4 | Robert F. Kennedy Stadium (1-1) | 9-11 | |
| » Starters: Dave Morehead vs Tom Cheney | Sixth | 3½ out |
| Sunday, May 10 |
| » Lost to Senators (11-15), 13-4 | Robert F. Kennedy Stadium (1-2) | 9-12 | Lost 2 |
| » Starters: Bill Monbouquette vs Claude Osteen | Sixth | 4 out |
| » Defeated Senators (11-16), 9-4 | Robert F. Kennedy Stadium (2-2) | 10-12 | |
| » Starters: Earl Wilson vs Jim Hannan | Sixth | 4 out |
| Monday, May 11 |
| » Lost to Indians (12-9), 11-7 | Cleveland Stadium (0-1) | 10-13 | |
| » Starters: Jack Lamabe vs Tommy John | Seventh | 4½ out |
| Future Red Sox Jeff Sellers is born in Compton, CA. |
| Tuesday, May 12 |
| » Lost to Indians (13-9), 6-5 | Cleveland Stadium (0-2) | 10-14 | Lost 2 |
| » Starters: Bill Spanswick vs Mudcat Grant | Eighth | 4½ out |
| Wednesday, May 13 |
| » Lost to Indians (14-9), 3-0 | Cleveland Stadium (0-3) | 10-15 | Lost 3 |
| » Starters: Dave Morehead vs Dick Donovan | Ninth | 5½ out |
| Friday, May 15 |
| » Lost to Twins (15-12), 1-0 | Fenway Park (5-6) | 10-16 | Lost 4 |
| » Starters: Camilo Pascual vs Bill Monbouquette | Tenth | 6 out |
| Saturday, May 16 |
| » Defeated Twins (15-13), 6-5 | Fenway Park (6-6) | 11-16 | |
| » Starters: Lee Stange vs Jack Lamabe | Eighth | 6 out |
| Sunday, May 17 |
| » Defeated Twins (15-14), 6-2 | Fenway Park (7-6) | 12-16 | Won 2 |
| » Starters: Jim Kaat vs Dave Morehead | Ninth | 5½ out |
| » Lost to Twins (16-14), 6-5 | Fenway Park (7-7) | 12-17 | |
| » Starters: Dick Stigman vs Earl Wilson | Ninth | 5½ out |
| Tuesday, May 19 |
| » Defeated Angels (13-19), 4-3 | Fenway Park (8-7) | 13-17 | |
| » Starters: Bo Belinsky vs Bill Monbouquette | Seventh | 5½ out |
| Wednesday, May 20 |
| » Defeated Angels (13-20), 4-3 | Fenway Park (9-7) | 14-17 | Won 2 |
| » Starters: Dean Chance vs Jack Lamabe | Sixth | 5 out |
| Thursday, May 21 |
| » Defeated Angels (13-21), 8-7 | Fenway Park (10-7) | 15-17 | Won 3 |
| » Starters: Barry Latman vs Dave Morehead | Fifth | 4½ out |
| Friday, May 22 |
| » Lost to Athletics (12-21), 4-3 | Fenway Park (10-8) | 15-18 | |
| » Starters: Orlando Pena vs Earl Wilson | Fifth | 5½ out |
| Saturday, May 23 |
| » Defeated Athletics (12-22), 5-4 | Fenway Park (11-8) | 16-18 | |
| » Starters: Aurelio Monteagudo vs Bill Monbouquette | Sixth | 5½ out |
| Sunday, May 24 |
| » Defeated Athletics (12-23), 6-2 | Fenway Park (12-8) | 17-18 | Won 2 |
| » Starters: Moe Drabowsky vs Jack Lamabe | Sixth | 4½ out |
| » Defeated Athletics (12-24), 3-1 | Fenway Park (13-8) | 18-18 | Won 3 |
| » Starters: Diego Segui vs Ed Connolly | Sixth | 4½ out |
| Monday, May 25 |
| » Defeated Senators (17-25), 6-5 | Fenway Park (14-8) | 19-18 | Won 4 |
| » Starters: Jim Duckworth vs Dave Morehead | Sixth | 4½ out |
| Tuesday, May 26 |
| » Defeated Senators (17-26), 3-2 | Fenway Park (15-8) | 20-18 | Won 5 |
| » Starters: Bennie Daniels vs Earl Wilson | Sixth | 4 out |
| Wednesday, May 27 |
| » Lost to Senators (18-26), 9-8 | Fenway Park (15-9) | 20-19 | |
| » Starters: Alan Koch vs Bill Monbouquette | Sixth | 4½ out |
| Friday, May 29 |
| » Lost to Twins (23-18), 3-2 | Metropolitan Stadium (0-1) | 20-20 | Lost 2 |
| » Starters: Jack Lamabe vs Jim Roland | Sixth | 5 out |
| Saturday, May 30 |
| » Lost to Twins (24-18), 7-3 | Metropolitan Stadium (0-2) | 20-21 | Lost 3 |
| » Starters: Dave Morehead vs Camilo Pascual | Sixth | 6 out |
| Sunday, May 31 |
| » Defeated Twins (24-19), 4-3 | Metropolitan Stadium (1-2) | 21-21 | |
| » Starters: Earl Wilson vs Lee Stange | Fifth | 6½ out |
| Former Red Sox Rabbit Warstler dies in N.Canton, OH at the age of 61. |
| Monday, June 1 |
| » Defeated Angels (16-30), 4-3 | Dodger Stadium (1-0) | 22-21 | Won 2 |
| » Starters: Bill Monbouquette vs Barry Latman | Sixth | 5½ out |
| Tuesday, June 2 |
| » Lost to Angels (17-30), 1-0 | Dodger Stadium (1-1) | 22-22 | |
| » Starters: Jack Lamabe vs Dean Chance | Sixth | 7 out |
| Wednesday, June 3 |
| » Lost to Angels (18-30), 2-0 | Dodger Stadium (1-2) | 22-23 | Lost 2 |
| » Starters: Dave Morehead vs Fred Newman | Sixth | 8½ out |
| » Lost to Angels (19-30), 9-8 | Dodger Stadium (1-3) | 22-24 | Lost 3 |
| » Starters: Bill Spanswick vs Ken McBride | Sixth | 8½ out |
| Friday, June 5 |
| » Defeated Athletics (15-30), 14-7 | Municipal Stadium (1-0) | 23-24 | |
| » Starters: Earl Wilson vs Moe Drabowsky | Fifth | 7½ out |
| Saturday, June 6 |
| » Defeated Athletics (15-31), 8-6 | Municipal Stadium (2-0) | 24-24 | Won 2 |
| » Starters: Jack Lamabe vs John O'Donoghue | Fifth | 7½ out |
| Sunday, June 7 |
| » Defeated Athletics (15-32), 9-5 | Municipal Stadium (3-0) | 25-24 | Won 3 |
| » Starters: Bill Monbouquette vs Orlando Pena | Sixth | 7½ out |
| » Lost to Athletics (16-32), 8-6 | Municipal Stadium (3-1) | 25-25 | |
| » Starters: Dave Morehead vs Diego Segui | Sixth | 7½ out |
| Tuesday, June 9 |
| » Defeated Yankees (25-20), 5-2 | Fenway Park (16-9) | 26-25 | |
| » Starters: Al Downing vs Earl Wilson | Sixth | 7½ out |
| Wednesday, June 10 |
| » Defeated Yankees (25-21), 7-6 | Fenway Park (17-9) | 27-25 | Won 2 |
| » Starters: Stan Williams vs Jack Lamabe | Sixth | 8 out |
| » Lost to Yankees (26-21), 10-6 | Fenway Park (17-10) | 27-26 | |
| » Starters: Ralph Terry vs Bill Spanswick | Sixth | 8 out |
| Thursday, June 11 |
| » Lost to Yankees (27-21), 8-4 | Fenway Park (17-11) | 27-27 | Lost 2 |
| » Starters: Jim Bouton vs Bill Monbouquette | Sixth | 8 out |
| Friday, June 12 |
| » Defeated Orioles (32-20), 7-3 | Fenway Park (18-11) | 28-27 | |
| » Starters: Steve Barber vs Dave Morehead | Sixth | 6½ out |
| Saturday, June 13 |
| » Defeated Orioles (32-21), 6-2 | Fenway Park (19-11) | 29-27 | Won 2 |
| » Starters: Wally Bunker vs Earl Wilson | Sixth | 5½ out |
| Sunday, June 14 |
| » Lost to Orioles (33-21), 10-1 | Fenway Park (19-12) | 29-28 | |
| » Starters: Dave McNally vs Jack Lamabe | Sixth | 6½ out |
| » Lost to Orioles (34-21), 8-1 | Fenway Park (19-13) | 29-29 | Lost 2 |
| » Starters: Chuck Estrada vs Ed Connolly | Sixth | 6½ out |
| Tuesday, June 16 |
| » Defeated Yankees (32-22), 6-5 | Yankee Stadium (2-0) | 30-29 | |
| » Starters: Dave Morehead vs Jim Bouton | Sixth | 6 out |
| » Lost to Yankees (33-22), 7-5 | Yankee Stadium (2-1) | 30-30 | |
| » Starters: Bill Monbouquette vs Whitey Ford | Sixth | 6 out |
| Wednesday, June 17 |
| » Defeated Yankees (33-23), 4-3 | Yankee Stadium (3-1) | 31-30 | |
| » Starters: Earl Wilson vs Al Downing | Sixth | 6 out |
| Thursday, June 18 |
| » Lost to Yankees (34-23), 6-3 | Yankee Stadium (3-2) | 31-31 | |
| » Starters: Jack Lamabe vs Rollie Sheldon | Sixth | 6 out |
| Friday, June 19 |
| » Lost to Orioles (37-24), 2-1 | Memorial Stadium (1-2) | 31-32 | Lost 2 |
| » Starters: Ed Connolly vs Robin Roberts | Sixth | 8 out |
| » Lost to Orioles (38-24), 6-5 | Memorial Stadium (1-3) | 31-33 | Lost 3 |
| » Starters: Bill Spanswick vs Chuck Estrada | Sixth | 8 out |
| Saturday, June 20 |
| » Lost to Orioles (39-24), 11-5 | Memorial Stadium (1-4) | 31-34 | Lost 4 |
| » Starters: Dave Morehead vs Milt Pappas | Sixth | 9 out |
| Sunday, June 21 |
| » Defeated Orioles (39-25), 9-6 | Memorial Stadium (2-4) | 32-34 | |
| » Starters: Earl Wilson vs Steve Barber | Sixth | 8 out |
| Tuesday, June 23 |
| » Lost to White Sox (35-26), 2-0 | Comiskey Park I (0-4) | 32-35 | |
| » Starters: Jack Lamabe vs Fred Talbot | Sixth | 9 out |
| Wednesday, June 24 |
| » Lost to White Sox (36-26), 8-1 | Comiskey Park I (0-5) | 32-36 | Lost 2 |
| » Starters: Ed Connolly vs Gary Peters | Sixth | 10 out |
| Friday, June 26 |
| » Defeated Indians (32-33), 3-2 | Fenway Park (20-13) | 33-36 | |
| » Starters: Tommy John vs Dave Morehead | Seventh | 10½ out |
| Saturday, June 27 |
| » Lost to Indians (33-33), 4-2 | Fenway Park (20-14) | 33-37 | |
| » Starters: Sonny Siebert vs Earl Wilson | Seventh | 11½ out |
| Sunday, June 28 |
| » Defeated Indians (33-34), 8-5 | Fenway Park (21-14) | 34-37 | |
| » Starters: Pedro Ramos vs Jack Lamabe | Fifth | 11 out |
| » Defeated Indians (33-35), 4-3 | Fenway Park (22-14) | 35-37 | Won 2 |
| » Starters: Dick Donovan vs Bill Monbouquette | Fifth | 11 out |
| Monday, June 29 |
| » Defeated Athletics (28-45), 4-3 | Fenway Park (23-14) | 36-37 | Won 3 |
| » Starters: Ted Bowsfield vs Earl Wilson | Fifth | 11 out |
| Tuesday, June 30 |
| » Lost to Athletics (29-45), 2-1 | Fenway Park (23-15) | 36-38 | |
| » Starters: Moe Drabowsky vs Dave Morehead | Fifth | 11 out |
| Wednesday, July 1 |
| » Lost to Twins (40-35), 14-3 | Fenway Park (23-16) | 36-39 | Lost 2 |
| » Starters: Mudcat Grant vs Ed Connolly | Fifth | 12 out |
| Thursday, July 2 |
| » Lost to Twins (41-35), 15-9 | Fenway Park (23-17) | 36-40 | Lost 3 |
| » Starters: Jim Kaat vs Jack Lamabe | Fifth | 12 out |
| Future Red Sox Jose Canseco is born in Havana, Cuba. |
| Friday, July 3 |
| » Lost to Angels (37-42), 5-3 | Fenway Park (23-18) | 36-41 | Lost 4 |
| » Starters: Barry Latman vs Bill Monbouquette | Sixth | 13 out |
| Saturday, July 4 |
| » Defeated Angels (37-43), 13-5 | Fenway Park (24-18) | 37-41 | |
| » Starters: Ken McBride vs Earl Wilson | Sixth | 12½ out |
| Sunday, July 5 |
| » Defeated Angels (37-44), 9-6 | Fenway Park (25-18) | 38-41 | Won 2 |
| » Starters: Dean Chance vs Dave Morehead | Sixth | 11½ out |
| Thursday, July 9 |
| » Lost to Tigers (39-39), 4-3 | Tiger Stadium (1-2) | 38-42 | |
| » Starters: Bill Monbouquette vs Dave Wickersham | Sixth | 13 out |
| Friday, July 10 |
| » Defeated Tigers (39-40), 7-6 | Tiger Stadium (2-2) | 39-42 | |
| » Starters: Earl Wilson vs Phil Regan | Sixth | 12½ out |
| » Lost to Tigers (40-40), 8-3 | Tiger Stadium (2-3) | 39-43 | |
| » Starters: Dave Morehead vs Ed Rakow | Sixth | 12½ out |
| Saturday, July 11 |
| » Lost to Tigers (41-40), 8-1 | Tiger Stadium (2-4) | 39-44 | Lost 2 |
| » Starters: Arnold Earley vs Joe Sparma | Sixth | 13½ out |
| Sunday, July 12 |
| » Defeated Senators (32-55), 5-3 | Robert F. Kennedy Stadium (3-2) | 40-44 | |
| » Starters: Jack Lamabe vs Bennie Daniels | Sixth | 13½ out |
| » Lost to Senators (33-55), 10-3 | Robert F. Kennedy Stadium (3-3) | 40-45 | |
| » Starters: Dave Morehead vs Alan Koch | Sixth | 13½ out |
| Monday, July 13 |
| » Defeated Senators (33-56), 7-0 | Robert F. Kennedy Stadium (4-3) | 41-45 | |
| » Starters: Bill Monbouquette vs Jim Duckworth | Sixth | 12½ out |
| Future Red Sox Greg Litton is born in New Orleans, LA. |
| Tuesday, July 14 |
| » Lost to White Sox (50-33), 4-2 | Fenway Park (25-19) | 41-46 | |
| » Starters: Juan Pizarro vs Earl Wilson | Sixth | 12½ out |
| Wednesday, July 15 |
| » Defeated White Sox (50-34), 11-2 | Fenway Park (26-19) | 42-46 | |
| » Starters: Fred Talbot vs Arnold Earley | Seventh | 12 out |
| Thursday, July 16 |
| » Lost to White Sox (51-34), 9-3 | Fenway Park (26-20) | 42-47 | |
| » Starters: John Buzhardt vs Jack Lamabe | Seventh | 12½ out |
| Friday, July 17 |
| » Defeated Senators (35-58), 5-0 | Fenway Park (27-20) | 43-47 | |
| » Starters: Alan Koch vs Bill Monbouquette | Seventh | 12½ out |
| Saturday, July 18 |
| » Defeated Senators (35-59), 12-6 | Fenway Park (28-20) | 44-47 | Won 2 |
| » Starters: Bennie Daniels vs Earl Wilson | Seventh | 12 out |
| Sunday, July 19 |
| » Defeated Senators (35-60), 11-10 | Fenway Park (29-20) | 45-47 | Won 3 |
| » Starters: Claude Osteen vs Dave Morehead | Seventh | 12½ out |
| » Lost to Senators (36-60), 5-4 | Fenway Park (29-21) | 45-48 | |
| » Starters: Buster Narum vs Arnold Earley | Seventh | 12½ out |
| Monday, July 20 |
| » Lost to Tigers (46-46), 7-5 | Fenway Park (29-22) | 45-49 | Lost 2 |
| » Starters: Phil Regan vs Bob Heffner | Seventh | 13 out |
| Tuesday, July 21 |
| » Defeated Tigers (46-47), 7-5 | Fenway Park (30-22) | 46-49 | |
| » Starters: Dave Wickersham vs Bill Monbouquette | Seventh | 11½ out |
| Wednesday, July 22 |
| » Lost to Tigers (47-47), 8-6 | Fenway Park (30-23) | 46-50 | |
| » Starters: Ed Rakow vs Earl Wilson | Sixth | 12½ out |
| Former Red Sox Bill Narleski dies in Laurel Springs, NJ at the age of 66. |
| Thursday, July 23 |
| » Defeated Tigers (47-48), 4-3 | Fenway Park (31-23) | 47-50 | |
| » Starters: Joe Sparma vs Dave Morehead | Sixth | 11½ out |
| Friday, July 24 |
| » Lost to Indians (43-51), 6-1 | Cleveland Stadium (0-4) | 47-51 | |
| » Starters: Bob Heffner vs Luis Tiant | Seventh | 13 out |
| Saturday, July 25 |
| » Defeated Indians (43-52), 4-3 | Cleveland Stadium (1-4) | 48-51 | |
| » Starters: Bill Monbouquette vs Jack Kralick | Seventh | 13 out |
| Sunday, July 26 |
| » Defeated Indians (43-53), 6-1 | Cleveland Stadium (2-4) | 49-51 | Won 2 |
| » Starters: Earl Wilson vs Lee Stange | Fifth | 12 out |
| » Defeated Indians (43-54), 3-1 | Cleveland Stadium (3-4) | 50-51 | Won 3 |
| » Starters: Ed Connolly vs Pedro Ramos | Fifth | 12 out |
| Tuesday, July 28 |
| » Lost to Athletics (39-61), 2-1 | Municipal Stadium (3-2) | 50-52 | |
| » Starters: Dave Morehead vs Orlando Pena | Sixth | 12½ out |
| Wednesday, July 29 |
| » Defeated Athletics (39-62), 3-2 | Municipal Stadium (4-2) | 51-52 | |
| » Starters: Bob Heffner vs Diego Segui | Fifth | 12½ out |
| Former Red Sox Vean Gregg dies in Aberdeen, WA at the age of 80. |
| Friday, July 31 |
| » Defeated Angels (54-53), 4-3 | Dodger Stadium (2-3) | 52-52 | Won 2 |
| » Starters: Bill Monbouquette vs Aubrey Gatewood | Fifth | 11½ out |
| » Major-league debuts: Bill Kelso (Angels) Tony Horton (Red Sox) |
| Saturday, August 1 |
| » Lost to Angels (55-53), 4-1 | Dodger Stadium (2-4) | 52-53 | |
| » Starters: Earl Wilson vs Dean Chance | Fifth | 12½ out |
| Sunday, August 2 |
| » Lost to Angels (56-53), 2-1 | Dodger Stadium (2-5) | 52-54 | Lost 2 |
| » Starters: Dave Morehead vs Fred Newman | Fifth | 13½ out |
| Tuesday, August 4 |
| » Lost to Twins (51-55), 12-4 | Metropolitan Stadium (1-3) | 52-55 | Lost 3 |
| » Starters: Bill Monbouquette vs Mudcat Grant | Fifth | 13½ out |
| » Major-league debuts: Jay Ritchie (Red Sox) |
| Wednesday, August 5 |
| » Lost to Twins (52-55), 6-1 | Metropolitan Stadium (1-4) | 52-56 | Lost 4 |
| » Starters: Earl Wilson vs Camilo Pascual | Seventh | 13½ out |
| Thursday, August 6 |
| » Lost to Twins (53-55), 6-5 | Metropolitan Stadium (1-5) | 52-57 | Lost 5 |
| » Starters: Bob Heffner vs Jim Roland | Seventh | 14½ out |
| Friday, August 7 |
| » Lost to White Sox (65-43), 2-0 | Comiskey Park I (0-6) | 52-58 | Lost 6 |
| » Starters: Ed Connolly vs Ray Herbert | Seventh | 15½ out |
| Saturday, August 8 |
| » Lost to White Sox (66-43), 9-2 | Comiskey Park I (0-7) | 52-59 | Lost 7 |
| » Starters: Dave Morehead vs Fred Talbot | Seventh | 16½ out |
| Sunday, August 9 |
| » Defeated White Sox (66-44), 6-3 | Comiskey Park I (1-7) | 53-59 | |
| » Starters: Bill Monbouquette vs John Buzhardt | Seventh | 16½ out |
| » Lost to White Sox (67-44), 4-1 | Comiskey Park I (1-8) | 53-60 | |
| » Starters: Earl Wilson vs Gary Peters | Seventh | 16½ out |
| Tuesday, August 11 |
| » Lost to Orioles (70-43), 8-7 | Memorial Stadium (2-5) | 53-61 | Lost 2 |
| » Starters: Bob Heffner vs Wally Bunker | Eighth | 17½ out |
| Wednesday, August 12 |
| » Lost to Orioles (71-43), 7-0 | Memorial Stadium (2-6) | 53-62 | Lost 3 |
| » Starters: Ed Connolly vs Milt Pappas | Eighth | 18½ out |
| Thursday, August 13 |
| » Lost to Orioles (72-43), 7-1 | Memorial Stadium (2-7) | 53-63 | Lost 4 |
| » Starters: Bill Monbouquette vs Robin Roberts | Eighth | 19½ out |
| Friday, August 14 |
| » Lost to White Sox (70-46), 11-1 | Fenway Park (31-24) | 53-64 | Lost 5 |
| » Starters: John Buzhardt vs Earl Wilson | Eighth | 20½ out |
| Saturday, August 15 |
| » Defeated White Sox (70-47), 5-2 | Fenway Park (32-24) | 54-64 | |
| » Starters: Fred Talbot vs Dave Morehead | Eighth | 19½ out |
| Sunday, August 16 |
| » Lost to White Sox (71-47), 2-1 | Fenway Park (32-25) | 54-65 | |
| » Starters: Joe Horlen vs Ed Connolly | Seventh | 19½ out |
| Tuesday, August 18 |
| » Lost to Orioles (74-45), 5-2 | Fenway Park (32-26) | 54-66 | Lost 2 |
| » Starters: Robin Roberts vs Bill Monbouquette | Seventh | 20½ out |
| Wednesday, August 19 |
| » Defeated Orioles (74-46), 4-3 | Fenway Park (33-26) | 55-66 | |
| » Starters: Wally Bunker vs Earl Wilson | Eighth | 19½ out |
| Thursday, August 20 |
| » Defeated Orioles (74-47), 4-3 | Fenway Park (34-26) | 56-66 | Won 2 |
| » Starters: Dave Vineyard vs Dave Morehead | Sixth | 19 out |
| Friday, August 21 |
| » Defeated Yankees (69-51), 7-0 | Fenway Park (35-26) | 57-66 | Won 3 |
| » Starters: Ralph Terry vs Bob Heffner | Seventh | 18½ out |
| Saturday, August 22 |
| » Defeated Yankees (69-52), 5-3 | Fenway Park (36-26) | 58-66 | Won 4 |
| » Starters: Al Downing vs Bill Monbouquette | Eighth | 19 out |
| » Lost to Yankees (70-52), 8-0 | Fenway Park (36-27) | 58-67 | |
| » Starters: Mel Stottlemyre vs Jack Lamabe | Eighth | 19 out |
| Sunday, August 23 |
| » Lost to Yankees (71-52), 4-3 | Fenway Park (36-28) | 58-68 | Lost 2 |
| » Starters: Jim Bouton vs Earl Wilson | Eighth | 19½ out |
| Future Red Sox Jeff Manto is born in Bristol, PA. |
| Monday, August 24 |
| Future Red Sox Kip Gross is born in Scottsbluff, NE. |
| Tuesday, August 25 |
| » Lost to Tigers (66-63), 11-6 | Fenway Park (36-29) | 58-69 | Lost 3 |
| » Starters: Denny McLain vs Dave Morehead | Eighth | 19½ out |
| Wednesday, August 26 |
| » Lost to Tigers (67-63), 4-1 | Fenway Park (36-30) | 58-70 | Lost 4 |
| » Starters: Dave Wickersham vs Bob Heffner | Eighth | 19½ out |
| Thursday, August 27 |
| » Lost to Tigers (68-63), 5-4 | Fenway Park (36-31) | 58-71 | Lost 5 |
| » Starters: Joe Sparma vs Jack Lamabe | Eighth | 20 out |
| Friday, August 28 |
| » Defeated Yankees (72-54), 5-3 | Yankee Stadium (4-2) | 59-71 | |
| » Starters: Bill Monbouquette vs Al Downing | Eighth | 19½ out |
| Saturday, August 29 |
| » Lost to Yankees (73-54), 10-2 | Yankee Stadium (4-3) | 59-72 | |
| » Starters: Earl Wilson vs Jim Bouton | Seventh | 21 out |
| » Lost to Yankees (74-54), 6-1 | Yankee Stadium (4-4) | 59-73 | Lost 2 |
| » Starters: Dave Morehead vs Whitey Ford | Seventh | 21 out |
| Sunday, August 30 |
| » Lost to Yankees (75-54), 9-3 | Yankee Stadium (4-5) | 59-74 | Lost 3 |
| » Starters: Bob Heffner vs Mel Stottlemyre | Eighth | 21 out |
| Tuesday, September 1 |
| » Defeated Athletics (49-84), 3-2 | Municipal Stadium (5-2) | 60-74 | |
| » Starters: Jack Lamabe vs Diego Segui | Eighth | 20 out |
| Future Red Sox David West is born in Memphis, TN. |
| Wednesday, September 2 |
| » Lost to Athletics (50-84), 9-5 | Municipal Stadium (5-3) | 60-75 | |
| » Starters: Bill Monbouquette vs Orlando Pena | Seventh | 21 out |
| Thursday, September 3 |
| » Defeated Athletics (50-85), 7-5 | Municipal Stadium (6-3) | 61-75 | |
| » Starters: Earl Wilson vs Moe Drabowsky | Eighth | 21 out |
| Friday, September 4 |
| » Lost to Twins (68-68), 14-3 | Metropolitan Stadium (1-6) | 61-76 | |
| » Starters: Bob Heffner vs Mudcat Grant | Eighth | 21 out |
| » Major-league debuts: Rich Reese (Twins) |
| Saturday, September 5 |
| » Lost to Twins (69-68), 10-4 | Metropolitan Stadium (1-7) | 61-77 | Lost 2 |
| » Starters: Jack Lamabe vs Jim Kaat | Eighth | 22 out |
| Sunday, September 6 |
| » Lost to Twins (70-68), 2-1 | Metropolitan Stadium (1-8) | 61-78 | Lost 3 |
| » Starters: Bill Monbouquette vs Gerry Arrigo | Eighth | 22½ out |
| Monday, September 7 |
| » Lost to Angels (73-70), 4-1 | Dodger Stadium (2-6) | 61-79 | Lost 4 |
| » Starters: Dave Morehead vs Dean Chance | Eighth | 23 out |
| » Lost to Angels (74-70), 4-3 | Dodger Stadium (2-7) | 61-80 | Lost 5 |
| » Starters: Pete Charton vs Ken McBride | Eighth | 23 out |
| » Major-league debuts: Jack Hiatt (Angels) |
| Future Red Sox Sergio Valdez is born in Elias Pina, D.R. |
| Wednesday, September 9 |
| » Defeated Indians (69-71), 6-5 | Cleveland Stadium (4-4) | 62-80 | |
| » Starters: Earl Wilson vs Luis Tiant | Eighth | 22½ out |
| Thursday, September 10 |
| » Lost to Indians (70-71), 5-4 | Cleveland Stadium (4-5) | 62-81 | |
| » Starters: Jack Lamabe vs Sonny Siebert | Eighth | 23½ out |
| Friday, September 11 |
| » Defeated Angels (74-71), 3-0 | Fenway Park (37-31) | 63-81 | |
| » Starters: Dean Chance vs Bill Monbouquette | Eighth | 23 out |
| Future Red Sox Ellis Burks is born in Vicksburg, MS. |
| Saturday, September 12 |
| » Lost to Angels (75-71), 3-2 | Fenway Park (37-32) | 63-82 | |
| » Starters: Fred Newman vs Pete Charton | Eighth | 24 out |
| Sunday, September 13 |
| » Defeated Angels (75-72), 4-3 | Fenway Park (38-32) | 64-82 | |
| » Starters: Aubrey Gatewood vs Earl Wilson | Eighth | 23 out |
| Monday, September 14 |
| » Lost to Athletics (54-91), 7-6 | Fenway Park (38-33) | 64-83 | |
| » Starters: Orlando Pena vs Dave Gray | Eighth | 24 out |
| Tuesday, September 15 |
| » Defeated Athletics (54-92), 8-0 | Fenway Park (39-33) | 65-83 | |
| » Starters: John O'Donoghue vs Ed Connolly | Eighth | 23 out |
| Wednesday, September 16 |
| » Defeated Athletics (54-93), 10-1 | Fenway Park (40-33) | 66-83 | Won 2 |
| » Starters: Blue Moon Odom vs Bill Monbouquette | Seventh | 22 out |
| Friday, September 18 |
| » Defeated Twins (74-75), 7-6 | Fenway Park (41-33) | 67-83 | Won 3 |
| » Starters: Dave Boswell vs Pete Charton | Eighth | 22 out |
| » Major-league debuts: Dave Boswell (Twins) |
| Saturday, September 19 |
| » Defeated Twins (74-76), 7-2 | Fenway Park (42-33) | 68-83 | Won 4 |
| » Starters: Mudcat Grant vs Earl Wilson | Eighth | 22 out |
| Sunday, September 20 |
| » Lost to Twins (75-76), 12-4 | Fenway Park (42-34) | 68-84 | |
| » Starters: Jim Kaat vs Ed Connolly | Eighth | 23 out |
| Tuesday, September 22 |
| » Defeated Senators (59-94), 3-0 | Robert F. Kennedy Stadium (5-3) | 69-84 | |
| » Starters: Bill Monbouquette vs Claude Osteen | Eighth | 23½ out |
| Wednesday, September 23 |
| » Lost to Senators (60-94), 1-0 | Robert F. Kennedy Stadium (5-4) | 69-85 | |
| » Starters: Pete Charton vs Don |
