| Friday, January 17 |
| Future Pirate Jeff Tabaka is born in Barberton, OH. |
| Wednesday, April 8 |
| Former Pirate Jim Umbricht dies in Houston, TX at the age of 34. |
| Friday, April 10 |
| Former Pirate Chief Yellowhorse dies in Pawnee, OK at the age of 67. |
| Sunday, April 12 |
| Future Pirate Jerry Goff is born in San Rafael, CA. |
| Monday, April 13 |
| » Major-league debuts: Bobby Knoop (Angels) |
| Future Pirate Doug Strange is born in Greenville, SC. |
| Tuesday, April 14 |
| » Lost to Cubs (1-0), 8-4 | Forbes Field (0-1) | 0-1 | |
| » Starters: Larry Jackson vs Bob Veale | Second | 1 out |
| Wednesday, April 15 |
| » Defeated Cubs (1-1), 5-4 | Forbes Field (1-1) | 1-1 | |
| » Starters: Fred Norman vs Joe Gibbon | Third | 1 out |
| Thursday, April 16 |
| Former Pirate Charlie Case dies in Batavia, OH at the age of 85. |
| Friday, April 17 |
| » Defeated Mets (0-3), 4-3 | Shea Stadium (1-0) | 2-1 | Won 2 |
| » Starters: Bob Friend vs Jack Fisher | Third | 1 out |
| Saturday, April 18 |
| » Defeated Mets (0-4), 9-5 | Shea Stadium (2-0) | 3-1 | Won 3 |
| » Starters: Don Schwall vs Larry Bearnarth | First | -- |
| Sunday, April 19 |
| » Lost to Mets (1-4), 6-0 | Shea Stadium (2-1) | 3-2 | |
| » Starters: Bob Veale vs Al Jackson | Third | 1 out |
| Tuesday, April 21 |
| » Defeated Cubs (2-4), 8-5 | Wrigley Field (1-0) | 4-2 | |
| » Starters: Vern Law vs Fred Norman | Third | ½ out |
| Thursday, April 23 |
| » Lost to Phillies (5-1), 6-5 | Shibe Park (0-1) | 4-3 | |
| » Starters: Joe Gibbon vs Art Mahaffey | Third | 1½ out |
| Friday, April 24 |
| » Defeated Mets (1-6), 9-4 | Forbes Field (2-1) | 5-3 | |
| » Starters: Al Jackson vs Bob Friend | Third | 1½ out |
| Saturday, April 25 |
| » Defeated Mets (1-7), 5-4 | Forbes Field (3-1) | 6-3 | Won 2 |
| » Starters: Jack Fisher vs Bob Veale | Third | ½ out |
| Sunday, April 26 |
| » Defeated Mets (1-8), 4-3 | Forbes Field (4-1) | 7-3 | Won 3 |
| » Starters: Jay Hook vs Vern Law | Third | 1 out |
| » Lost to Mets (2-8), 3-2 | Forbes Field (4-2) | 7-4 | |
| » Starters: Tracy Stallard vs Don Schwall | Third | 1 out |
| Tuesday, April 28 |
| » Lost to Braves (7-5), 9-5 | County Stadium (0-1) | 7-5 | Lost 2 |
| » Starters: Bob Friend vs Denny Lemaster | Third | 2 out |
| Wednesday, April 29 |
| » Lost to Braves (8-5), 1-0 | County Stadium (0-2) | 7-6 | Lost 3 |
| » Starters: Bob Veale vs Tony Cloninger | Fifth | 2½ out |
| Friday, May 1 |
| » Lost to Cardinals (9-6), 6-2 | Sportsman's Park III (0-1) | 7-7 | Lost 4 |
| » Starters: Vern Law vs Roger Craig | Fifth | 4 out |
| Future Pirate Jose Lind is born in Toa Baja, P.R. |
| Saturday, May 2 |
| » Defeated Cardinals (9-7), 5-4 | Sportsman's Park III (1-1) | 8-7 | |
| » Starters: Bob Friend vs Curt Simmons | Fifth | 3 out |
| Sunday, May 3 |
| » Defeated Cardinals (9-8), 12-8 | Sportsman's Park III (2-1) | 9-7 | Won 2 |
| » Starters: Bob Veale vs Ernie Broglio | Third | 2 out |
| Monday, May 4 |
| » Defeated Reds (9-9), 4-2 | Crosley Field (1-0) | 10-7 | Won 3 |
| » Starters: Joe Gibbon vs Joey Jay | Fourth | 2 out |
| Tuesday, May 5 |
| » Lost to Reds (10-9), 5-4 | Crosley Field (1-1) | 10-8 | |
| » Starters: Vern Law vs Joe Nuxhall | Fifth | 3 out |
| Wednesday, May 6 |
| » Defeated Cardinals (11-9), 1-0 | Forbes Field (5-2) | 11-8 | |
| » Starters: Ray Sadecki vs Bob Friend | Fourth | 2 out |
| Thursday, May 7 |
| » Lost to Cardinals (12-9), 4-2 | Forbes Field (5-3) | 11-9 | |
| » Starters: Curt Simmons vs Bob Veale | Fifth | 3 out |
| Friday, May 8 |
| » Lost to Braves (13-8), 2-1 | Forbes Field (5-4) | 11-10 | Lost 2 |
| » Starters: Tony Cloninger vs Joe Gibbon | Fifth | 4 out |
| Saturday, May 9 |
| » Defeated Braves (13-9), 10-0 | Forbes Field (6-4) | 12-10 | |
| » Starters: Denny Lemaster vs Vern Law | Fifth | 4 out |
| Sunday, May 10 |
| » Lost to Braves (14-9), 11-5 | Forbes Field (6-5) | 12-11 | |
| » Starters: Warren Spahn vs Bob Friend | Fifth | 3½ out |
| » Defeated Braves (14-10), 6-5 | Forbes Field (7-5) | 13-11 | |
| » Starters: Bob Sadowski vs Tommie Sisk | Fifth | 3½ out |
| » Major-league debuts: Steve Blass (Pirates) |
| Monday, May 11 |
| » Lost to Reds (13-12), 7-6 | Forbes Field (7-6) | 13-12 | |
| » Starters: Sammy Ellis vs Bob Veale | Fifth | 3½ out |
| Tuesday, May 12 |
| » Defeated Reds (13-13), 3-2 | Forbes Field (8-6) | 14-12 | |
| » Starters: Jim Maloney vs Joe Gibbon | Fifth | 3½ out |
| Friday, May 15 |
| » Lost to Dodgers (13-16), 6-0 | Dodger Stadium (0-1) | 14-13 | |
| » Starters: Bob Friend vs Phil Ortega | Fifth | 3 out |
| Saturday, May 16 |
| » Defeated Dodgers (13-17), 7-4 | Dodger Stadium (1-1) | 15-13 | |
| » Starters: Bob Veale vs Nick Willhite | Fourth | 2½ out |
| Sunday, May 17 |
| » Lost to Dodgers (14-17), 3-2 | Dodger Stadium (1-2) | 15-14 | |
| » Starters: Vern Law vs Sandy Koufax | Fourth | 3½ out |
| » Defeated Dodgers (14-18), 8-3 | Dodger Stadium (2-2) | 16-14 | |
| » Starters: Joe Gibbon vs Johnny Podres | Fourth | 3½ out |
| Monday, May 18 |
| » Defeated Dodgers (14-19), 4-2 | Dodger Stadium (3-2) | 17-14 | Won 2 |
| » Starters: Steve Blass vs Don Drysdale | Fourth | 2½ out |
| Tuesday, May 19 |
| » Lost to Astros (15-20), 3-1 | Colt Stadium (0-1) | 17-15 | |
| » Starters: Bob Friend vs Bob Bruce | Fourth | 3½ out |
| Wednesday, May 20 |
| » Defeated Astros (15-21), 4-3 | Colt Stadium (1-1) | 18-15 | |
| » Starters: Bob Veale vs Don Nottebart | Fourth | 2½ out |
| Thursday, May 21 |
| » Lost to Astros (16-21), 3-1 | Colt Stadium (1-2) | 18-16 | |
| » Starters: Vern Law vs Turk Farrell | Fifth | 3½ out |
| Friday, May 22 |
| » Lost to Giants (22-12), 8-3 | Candlestick Park (0-1) | 18-17 | Lost 2 |
| » Starters: Steve Blass vs Ron Herbel | Fifth | 4½ out |
| Saturday, May 23 |
| » Defeated Giants (22-13), 9-2 | Candlestick Park (1-1) | 19-17 | |
| » Starters: Bob Friend vs Gaylord Perry | Fifth | 3½ out |
| Sunday, May 24 |
| » Defeated Giants (22-14), 3-0 | Candlestick Park (2-1) | 20-17 | Won 2 |
| » Starters: Bob Veale vs Jack Sanford | Fifth | 2 out |
| » Defeated Giants (22-15), 5-3 | Candlestick Park (3-1) | 21-17 | Won 3 |
| » Starters: Tom Butters vs Bob Shaw | Fifth | 2 out |
| Tuesday, May 26 |
| » Defeated Phillies (21-14), 13-4 | Forbes Field (9-6) | 22-17 | Won 4 |
| » Starters: Chris Short vs Vern Law | Third | 2 out |
| Wednesday, May 27 |
| » Lost to Phillies (22-14), 2-0 | Forbes Field (9-7) | 22-18 | |
| » Starters: Art Mahaffey vs Bob Friend | Fourth | 2 out |
| Thursday, May 28 |
| » Defeated Phillies (22-15), 6-5 | Forbes Field (10-7) | 23-18 | |
| » Starters: Dennis Bennett vs Bob Veale | Third | 2 out |
| Friday, May 29 |
| » Lost to Dodgers (19-23), 4-1 | Forbes Field (10-8) | 23-19 | |
| » Starters: Joe Moeller vs Steve Blass | Fourth | 2 out |
| Saturday, May 30 |
| » Lost to Dodgers (20-23), 10-3 | Forbes Field (10-9) | 23-20 | Lost 2 |
| » Starters: Don Drysdale vs Vern Law | Fourth | 3 out |
| Sunday, May 31 |
| » Lost to Dodgers (21-23), 6-4 | Forbes Field (10-10) | 23-21 | Lost 3 |
| » Starters: Sandy Koufax vs Bob Friend | Fourth | 4 out |
| Tuesday, June 2 |
| » Defeated Giants (26-18), 3-1 | Forbes Field (11-10) | 24-21 | |
| » Starters: Bob Hendley vs Bob Veale | Fourth | 4 out |
| Wednesday, June 3 |
| » Lost to Giants (27-18), 3-0 | Forbes Field (11-11) | 24-22 | |
| » Starters: Ron Herbel vs Vern Law | Fourth | 5 out |
| Thursday, June 4 |
| » Defeated Giants (27-19), 4-2 | Forbes Field (12-11) | 25-22 | |
| » Starters: Bobby Bolin vs Steve Blass | Fourth | 4 out |
| Friday, June 5 |
| » Defeated Astros (22-28), 4-3 | Forbes Field (13-11) | 26-22 | Won 2 |
| » Starters: Don Nottebart vs Bob Friend | Third | 3 out |
| Sunday, June 7 |
| » Lost to Astros (23-28), 6-3 | Forbes Field (13-12) | 26-23 | |
| » Starters: Ken Johnson vs Bob Veale | Fourth | 3½ out |
| » Defeated Astros (23-29), 6-1 | Forbes Field (14-12) | 27-23 | |
| » Starters: Bob Bruce vs Vern Law | Fourth | 3½ out |
| Tuesday, June 9 |
| » Lost to Phillies (28-19), 4-3 | Shibe Park (0-2) | 27-24 | |
| » Starters: Joe Gibbon vs Art Mahaffey | Fourth | 3 out |
| » Defeated Phillies (28-20), 4-0 | Shibe Park (1-2) | 28-24 | |
| » Starters: Steve Blass vs Ray Culp | Fourth | 3 out |
| Wednesday, June 10 |
| » Lost to Phillies (29-20), 4-1 | Shibe Park (1-3) | 28-25 | |
| » Starters: Bob Friend vs Chris Short | Fourth | 3½ out |
| Friday, June 12 |
| » Lost to Cubs (26-26), 7-1 | Wrigley Field (1-1) | 28-26 | Lost 2 |
| » Starters: Bob Veale vs Bob Buhl | Fourth | 3 out |
| Saturday, June 13 |
| » Defeated Cubs (26-27), 10-7 | Wrigley Field (2-1) | 29-26 | |
| » Starters: Vern Law vs Lew Burdette | Fourth | 3 out |
| Sunday, June 14 |
| » Lost to Cubs (27-27), 5-2 | Wrigley Field (2-2) | 29-27 | |
| » Starters: Steve Blass vs Dick Ellsworth | Fourth | 4½ out |
| Tuesday, June 16 |
| » Defeated Mets (19-41), 2-1 | Forbes Field (15-12) | 30-27 | |
| » Starters: Jack Fisher vs Bob Veale | Fourth | 4½ out |
| Wednesday, June 17 |
| » Defeated Mets (19-42), 3-2 | Forbes Field (16-12) | 31-27 | Won 2 |
| » Starters: Tracy Stallard vs Bob Friend | Third | 3½ out |
| Thursday, June 18 |
| » Defeated Mets (19-43), 10-0 | Forbes Field (17-12) | 32-27 | Won 3 |
| » Starters: Al Jackson vs Vern Law | Third | 3½ out |
| Saturday, June 20 |
| » Defeated Cubs (28-30), 2-0 | Forbes Field (18-12) | 33-27 | Won 4 |
| » Starters: Ernie Broglio vs Joe Gibbon | Third | 3½ out |
| Sunday, June 21 |
| » Lost to Cubs (29-30), 2-1 | Forbes Field (18-13) | 33-28 | |
| » Starters: Larry Jackson vs Bob Veale | Fourth | 5½ out |
| » Lost to Cubs (30-30), 7-2 | Forbes Field (18-14) | 33-29 | Lost 2 |
| » Starters: Lew Burdette vs Steve Blass | Fourth | 5½ out |
| Tuesday, June 23 |
| » Defeated Mets (20-48), 5-1 | Shea Stadium (3-1) | 34-29 | |
| » Starters: Vern Law vs Carl Willey | Third | 5 out |
| Wednesday, June 24 |
| » Defeated Mets (20-49), 3-1 | Shea Stadium (4-1) | 35-29 | Won 2 |
| » Starters: Bob Friend vs Galen Cisco | Third | 5 out |
| Thursday, June 25 |
| » Defeated Mets (20-50), 8-1 | Shea Stadium (5-1) | 36-29 | Won 3 |
| » Starters: Joe Gibbon vs Jack Fisher | Third | 4½ out |
| Friday, June 26 |
| » Defeated Reds (35-32), 8-3 | Forbes Field (19-14) | 37-29 | Won 4 |
| » Starters: Joey Jay vs Bob Veale | Third | 4½ out |
| Saturday, June 27 |
| » Defeated Reds (35-33), 4-2 | Forbes Field (20-14) | 38-29 | Won 5 |
| » Starters: Bob Purkey vs Steve Blass | Third | 3½ out |
| Sunday, June 28 |
| » Lost to Reds (36-33), 6-2 | Forbes Field (20-15) | 38-30 | |
| » Starters: John Tsitouris vs Vern Law | Third | 5 out |
| » Lost to Reds (37-33), 6-5 | Forbes Field (20-16) | 38-31 | Lost 2 |
| » Starters: Jim Maloney vs Bob Friend | Third | 5 out |
| Monday, June 29 |
| » Lost to Dodgers (34-38), 7-6 | Dodger Stadium (3-3) | 38-32 | Lost 3 |
| » Starters: Joe Gibbon vs Larry Miller | Third | 5 out |
| Wednesday, July 1 |
| » Lost to Giants (46-28), 2-1 | Candlestick Park (3-2) | 38-33 | Lost 4 |
| » Starters: Bob Veale vs Juan Marichal | Third | 6½ out |
| Thursday, July 2 |
| » Lost to Giants (47-28), 6-5 | Candlestick Park (3-3) | 38-34 | Lost 5 |
| » Starters: Steve Blass vs Bob Hendley | Fourth | 7½ out |
| Friday, July 3 |
| » Defeated Astros (36-42), 2-1 | Colt Stadium (2-2) | 39-34 | |
| » Starters: Vern Law vs Hal Brown | Fourth | 6½ out |
| Saturday, July 4 |
| » Lost to Astros (37-42), 3-1 | Colt Stadium (2-3) | 39-35 | |
| » Starters: Bob Friend vs Bob Bruce | Fourth | 7 out |
| Sunday, July 5 |
| » Defeated Astros (37-43), 7-1 | Colt Stadium (3-3) | 40-35 | |
| » Starters: Joe Gibbon vs Turk Farrell | Fourth | 7 out |
| Wednesday, July 8 |
| » Defeated Reds (42-36), 9-1 | Forbes Field (21-16) | 41-35 | Won 2 |
| » Starters: Jim Maloney vs Bob Veale | Third | 6½ out |
| Future Pirate Bob Kipper is born in Aurora, IL. |
| Thursday, July 9 |
| » Lost to Braves (39-40), 11-6 | Forbes Field (21-17) | 41-36 | |
| » Starters: Warren Spahn vs Vern Law | Fourth | 7½ out |
| Friday, July 10 |
| » Defeated Braves (39-41), 5-1 | Forbes Field (22-17) | 42-36 | |
| » Starters: Tony Cloninger vs Bob Friend | Fourth | 6½ out |
| Saturday, July 11 |
| » Lost to Braves (40-41), 9-8 | Forbes Field (22-18) | 42-37 | |
| » Starters: Denny Lemaster vs Joe Gibbon | Fourth | 6½ out |
| Monday, July 13 |
| » Lost to Cardinals (42-41), 5-4 | Forbes Field (22-19) | 42-38 | Lost 2 |
| » Starters: Roger Craig vs Steve Blass | Fourth | 8 out |
| » Lost to Cardinals (43-41), 12-5 | Forbes Field (22-20) | 42-39 | Lost 3 |
| » Starters: Mike Cuellar vs Vern Law | Fourth | 8 out |
| Tuesday, July 14 |
| » Defeated Phillies (49-33), 4-3 | Forbes Field (23-20) | 43-39 | |
| » Starters: Cal McLish vs Bob Veale | Fourth | 7 out |
| Wednesday, July 15 |
| » Defeated Phillies (49-34), 3-0 | Forbes Field (24-20) | 44-39 | Won 2 |
| » Starters: Jim Bunning vs Bob Friend | Fourth | 6 out |
| Thursday, July 16 |
| » Lost to Phillies (50-34), 7-5 | Forbes Field (24-21) | 44-40 | |
| » Starters: Art Mahaffey vs Joe Gibbon | Fourth | 6 out |
| Saturday, July 18 |
| » Defeated Braves (45-43), 8-2 | County Stadium (1-2) | 45-40 | |
| » Starters: Bob Veale vs Warren Spahn | Fourth | 5½ out |
| Sunday, July 19 |
| » Lost to Braves (46-43), 6-2 | County Stadium (1-3) | 45-41 | |
| » Starters: Bob Friend vs Tony Cloninger | Fifth | 6½ out |
| » Lost to Braves (47-43), 5-4 | County Stadium (1-4) | 45-42 | Lost 2 |
| » Starters: Steve Blass vs Denny Lemaster | Fifth | 6½ out |
| Tuesday, July 21 |
| » Defeated Cardinals (47-45), 8-4 | Sportsman's Park III (3-1) | 46-42 | |
| » Starters: Joe Gibbon vs Ray Sadecki | Fourth | 6 out |
| Wednesday, July 22 |
| » Defeated Cardinals (47-46), 13-2 | Sportsman's Park III (4-1) | 47-42 | Won 2 |
| » Starters: Bob Veale vs Roger Craig | Fourth | 6 out |
| Thursday, July 23 |
| » Defeated Cardinals (47-47), 8-5 | Sportsman's Park III (5-1) | 48-42 | Won 3 |
| » Starters: Don Schwall vs Mike Cuellar | Fourth | 6 out |
| » Major-league debuts: Ed Spiezio (Cardinals) |
| Friday, July 24 |
| » Lost to Reds (53-43), 2-0 | Crosley Field (1-2) | 48-43 | |
| » Starters: Bob Friend vs Jim O'Toole | Fourth | 7 out |
| Future Pirate Barry Bonds is born in Riverside, CA. |
| Saturday, July 25 |
| » Defeated Reds (53-44), 6-3 | Crosley Field (2-2) | 49-43 | |
| » Starters: Vern Law vs Joe Nuxhall | Fourth | 6 out |
| Sunday, July 26 |
| » Lost to Reds (54-44), 7-2 | Crosley Field (2-3) | 49-44 | |
| » Starters: Joe Gibbon vs Joey Jay | Fourth | 5 out |
| » Defeated Reds (54-45), 5-1 | Crosley Field (3-3) | 50-44 | |
| » Starters: Bob Veale vs John Tsitouris | Fourth | 5 out |
| » Major-league debuts: Tony Perez (Reds) |
| Wednesday, July 29 |
| » Defeated Astros (45-56), 5-2 | Forbes Field (25-21) | 51-44 | Won 2 |
| » Starters: Turk Farrell vs Bob Friend | Fourth | 4½ out |
| Thursday, July 30 |
| » Defeated Astros (45-57), 1-0 | Forbes Field (26-21) | 52-44 | Won 3 |
| » Starters: Bob Bruce vs Vern Law | Third | 4 out |
| » Defeated Astros (45-58), 8-3 | Forbes Field (27-21) | 53-44 | Won 4 |
| » Starters: Jim Owens vs Don Schwall | Third | 4 out |
| Friday, July 31 |
| » Lost to Giants (59-44), 8-6 | Forbes Field (27-22) | 53-45 | |
| » Starters: Bobby Bolin vs Bob Veale | Fourth | 5 out |
| Saturday, August 1 |
| » Defeated Giants (59-45), 6-1 | Forbes Field (28-22) | 54-45 | |
| » Starters: Ron Herbel vs Joe Gibbon | Fourth | 5 out |
| Sunday, August 2 |
| » Lost to Giants (60-45), 2-1 | Forbes Field (28-23) | 54-46 | |
| » Starters: Bob Hendley vs Bob Friend | Fourth | 5 out |
| Monday, August 3 |
| » Defeated Giants (60-46), 3-2 | Forbes Field (29-23) | 55-46 | |
| » Starters: Bobby Bolin vs Vern Law | Third | 4½ out |
| Future Pirate Kevin Elster is born in San Pedro, CA. |
| Tuesday, August 4 |
| » Lost to Dodgers (52-51), 5-1 | Forbes Field (29-24) | 55-47 | |
| » Starters: Sandy Koufax vs Bob Veale | Fourth | 5½ out |
| » Lost to Dodgers (53-51), 10-7 | Forbes Field (29-25) | 55-48 | Lost 2 |
| » Starters: Joe Moeller vs Don Schwall | Fourth | 5½ out |
| » Major-league debuts: John Gelnar (Pirates) |
| Wednesday, August 5 |
| » Defeated Dodgers (53-52), 4-3 | Forbes Field (30-25) | 56-48 | |
| » Starters: Don Drysdale vs Joe Gibbon | Fourth | 6 out |
| Thursday, August 6 |
| » Defeated Dodgers (53-53), 4-1 | Forbes Field (31-25) | 57-48 | Won 2 |
| » Starters: Larry Miller vs Bob Friend | Fourth | 5 out |
| Friday, August 7 |
| » Lost to Cubs (51-55), 7-3 | Forbes Field (31-26) | 57-49 | |
| » Starters: Larry Jackson vs Vern Law | Fourth | 6½ out |
| » Lost to Cubs (52-55), 4-3 | Forbes Field (31-27) | 57-50 | Lost 2 |
| » Starters: Ernie Broglio vs Steve Blass | Fourth | 6½ out |
| Saturday, August 8 |
| » Defeated Cubs (52-56), 5-2 | Forbes Field (32-27) | 58-50 | |
| » Starters: Lew Burdette vs Bob Veale | Fourth | 6½ out |
| Sunday, August 9 |
| » Defeated Cubs (52-57), 2-0 | Forbes Field (33-27) | 59-50 | Won 2 |
| » Starters: Bob Buhl vs Don Schwall | Fourth | 6½ out |
| Tuesday, August 11 |
| » Lost to Mets (35-78), 3-2 | Forbes Field (33-28) | 59-51 | |
| » Starters: Jack Fisher vs Bob Friend | Fourth | 7½ out |
| Wednesday, August 12 |
| » Defeated Mets (35-79), 5-4 | Forbes Field (34-28) | 60-51 | |
| » Starters: Dennis Ribant vs Joe Gibbon | Fourth | 7½ out |
| Thursday, August 13 |
| Future Pirate Tom Prince is born in Kankakee, IL. |
| Friday, August 14 |
| » Defeated Cubs (53-60), 3-2 | Wrigley Field (3-2) | 61-51 | Won 2 |
| » Starters: Bob Veale vs Bob Buhl | Fourth | 8 out |
| » Lost to Cubs (54-60), 4-2 | Wrigley Field (3-3) | 61-52 | |
| » Starters: Vern Law vs Lew Burdette | Fourth | 8 out |
| Saturday, August 15 |
| » Defeated Cubs (54-61), 5-4 | Wrigley Field (4-3) | 62-52 | |
| » Starters: Don Schwall vs Dick Ellsworth | Third | 8 out |
| Sunday, August 16 |
| » Lost to Cubs (55-61), 5-4 | Wrigley Field (4-4) | 62-53 | |
| » Starters: Bob Friend vs Larry Jackson | Third | 7½ out |
| » Defeated Cubs (55-62), 7-4 | Wrigley Field (5-4) | 63-53 | |
| » Starters: Steve Blass vs Sterling Slaughter | Third | 7½ out |
| Future Pirate Rick Reed is born in Huntington, WV. |
| Monday, August 17 |
| » Lost to Mets (37-82), 5-0 | Shea Stadium (5-2) | 63-54 | |
| » Starters: Bob Veale vs Dennis Ribant | Fourth | 8½ out |
| Tuesday, August 18 |
| » Lost to Mets (38-82), 7-3 | Shea Stadium (5-3) | 63-55 | Lost 2 |
| » Starters: Joe Gibbon vs Al Jackson | Fifth | 8½ out |
| Wednesday, August 19 |
| » Lost to Mets (39-82), 4-2 | Shea Stadium (5-4) | 63-56 | Lost 3 |
| » Starters: Vern Law vs Tracy Stallard | Fifth | 9½ out |
| Thursday, August 20 |
| » Lost to Phillies (73-46), 2-0 | Shibe Park (1-4) | 63-57 | Lost 4 |
| » Starters: Bob Friend vs Art Mahaffey | Fourth | 11½ out |
| » Lost to Phillies (74-46), 3-2 | Shibe Park (1-5) | 63-58 | Lost 5 |
| » Starters: Don Schwall vs Rick Wise | Fourth | 11½ out |
| Friday, August 21 |
| » Lost to Phillies (75-46), 2-0 | Shibe Park (1-6) | 63-59 | Lost 6 |
| » Starters: Bob Veale vs Chris Short | Sixth | 12½ out |
| Saturday, August 22 |
| » Defeated Phillies (75-47), 9-4 | Shibe Park (2-6) | 64-59 | |
| » Starters: Frank Bork vs Dennis Bennett | Fifth | 11½ out |
| Sunday, August 23 |
| » Lost to Phillies (76-47), 9-3 | Shibe Park (2-7) | 64-60 | |
| » Starters: Joe Gibbon vs Jim Bunning | Fourth | 12½ out |
| Monday, August 24 |
| » Lost to Cardinals (66-58), 5-1 | Sportsman's Park III (5-2) | 64-61 | Lost 2 |
| » Starters: Bob Friend vs Bob Gibson | Fifth | 12½ out |
| Tuesday, August 25 |
| » Lost to Cardinals (67-58), 7-6 | Sportsman's Park III (5-3) | 64-62 | Lost 3 |
| » Starters: Bob Veale vs Curt Simmons | Sixth | 12½ out |
| Wednesday, August 26 |
| » Lost to Cardinals (68-58), 4-2 | Sportsman's Park III (5-4) | 64-63 | Lost 4 |
| » Starters: Frank Bork vs Mike Cuellar | Sixth | 13½ out |
| Friday, August 28 |
| » Defeated Phillies (77-50), 4-2 | Forbes Field (35-28) | 65-63 | |
| » Starters: Jim Bunning vs Joe Gibbon | Sixth | 12½ out |
| Saturday, August 29 |
| » Lost to Phillies (78-50), 10-8 | Forbes Field (35-29) | 65-64 | |
| » Starters: Art Mahaffey vs Bob Friend | Sixth | 13½ out |
| Sunday, August 30 |
| » Defeated Phillies (78-51), 10-2 | Forbes Field (36-29) | 66-64 | |
| » Starters: Chris Short vs Bob Veale | Fifth | 12½ out |
| Tuesday, September 1 |
| » Defeated Dodgers (63-67), 5-2 | Forbes Field (37-29) | 67-64 | Won 2 |
| » Starters: Phil Ortega vs Bob Friend | Fifth | 12½ out |
| Wednesday, September 2 |
| » Lost to Dodgers (64-67), 8-5 | Forbes Field (37-30) | 67-65 | |
| » Starters: Howie Reed vs Joe Gibbon | Fifth | 13½ out |
| Friday, September 4 |
| » Defeated Astros (58-78), 10-2 | Forbes Field (38-30) | 68-65 | |
| » Starters: Bob Bruce vs Bob Veale | Fifth | 13 out |
| Saturday, September 5 |
| » Defeated Astros (58-79), 4-1 | Forbes Field (39-30) | 69-65 | Won 2 |
| » Starters: Ken Johnson vs Bob Friend | Fifth | 13 out |
| Sunday, September 6 |
| » Defeated Astros (58-80), 1-0 | Forbes Field (40-30) | 70-65 | Won 3 |
| » Starters: Don Nottebart vs Vern Law | Fifth | 12 out |
| Monday, September 7 |
| » Lost to Giants (77-62), 6-4 | Forbes Field (40-31) | 70-66 | |
| » Starters: Gaylord Perry vs Joe Gibbon | Fourth | 13 out |
| » Lost to Giants (78-62), 9-6 | Forbes Field (40-32) | 70-67 | Lost 2 |
| » Starters: Ron Herbel vs Don Schwall | Fourth | 13 out |
| Wednesday, September 9 |
| » Defeated Reds (77-62), 4-1 | Forbes Field (41-32) | 71-67 | |
| » Starters: Joey Jay vs Bob Veale | Fifth | 11½ out |
| Thursday, September 10 |
| » Lost to Reds (78-62), 3-0 | Forbes Field (41-33) | 71-68 | |
| » Starters: Bob Purkey vs Bob Friend | Fifth | 12½ out |
| Friday, September 11 |
| » Defeated Astros (58-85), 3-0 | Colt Stadium (4-3) | 72-68 | |
| » Starters: Vern Law vs Don Nottebart | Sixth | 12½ out |
| Saturday, September 12 |
| » Lost to Astros (59-85), 2-1 | Colt Stadium (4-4) | 72-69 | |
| » Starters: Tom Butters vs Don Larsen | Sixth | 12½ out |
| Sunday, September 13 |
| » Defeated Astros (59-86), 3-0 | Colt Stadium (5-4) | 73-69 | |
| » Starters: Don Cardwell vs Turk Farrell | Sixth | 12½ out |
| Monday, September 14 |
| » Defeated Dodgers (72-72), 7-2 | Dodger Stadium (4-3) | 74-69 | Won 2 |
| » Starters: Bob Veale vs Howie Reed | Fifth | 12½ out |
| Tuesday, September 15 |
| » Lost to Dodgers (73-72), 5-3 | Dodger Stadium (4-4) | 74-70 | |
| » Starters: Bob Friend vs Larry Miller | Fifth | 13½ out |
| Wednesday, September 16 |
| » Defeated Dodgers (73-73), 7-5 | Dodger Stadium (5-4) | 75-70 | |
| » Starters: Vern Law vs Phil Ortega | Fifth | 12½ out |
| » Major-league debuts: Willie Crawford and John Purdin (Dodgers) |
| Friday, September 18 |
| » Defeated Giants (81-67), 4-3 | Candlestick Park (4-3) | 76-70 | Won 2 |
| » Starters: Bob Veale vs Dick Estelle | Fifth | 12 out |
| Saturday, September 19 |
| » Lost to Giants (82-67), 13-4 | Candlestick Park (4-4) | 76-71 | |
| » Starters: Bob Friend vs Juan Marichal | Fifth | 12 out |
| » Major-league debuts: Jerry May (Pirates) |
| Sunday, September 20 |
| » Lost to Giants (83-67), 4-3 | Candlestick Park (4-5) | 76-72 | Lost 2 |
| » Starters: Don Cardwell vs Gaylord Perry | Fifth | 13 out |
| Tuesday, September 22 |
| » Lost to Braves (78-72), 2-0 | Forbes Field (41-34) | 76-73 | Lost 3 |
| » Starters: Denny Lemaster vs Bob Veale | Sixth | 12½ out |
| Wednesday, September 23 |
| » Defeated Braves (78-73), 7-4 | Forbes Field (42-34) | 77-73 | |
| » Starters: Tony Cloninger vs Vern Law | Sixth | 11½ out |
| Thursday, September 24 |
| » Lost to Cardinals (85-67), 4-2 | Forbes Field (42-35) | 77-74 | |
| » Starters: Bob Gibson vs Wilbur Wood | Sixth | 12 out |
| » Lost to Cardinals (86-67), 4-0 | Forbes Field (42-36) | 77-75 | Lost 2 |
| » Starters: Ray Sadecki vs Tom Butters | Sixth | 12 out |
| Friday, September 25 |
| » Lost to Cardinals (87-67), 5-3 | Forbes Field (42-37) | 77-76 | Lost 3 |
| » Starters: Gordie Richardson vs Don Cardwell | Sixth | 12 out |
| Saturday, September 26 |
| » Lost to Cardinals (88-67), 6-3 | Forbes Field (42-38) | 77-77 | Lost 4 |
| » Starters: Curt Simmons vs Bob Veale | Sixth | 12 out |
| Sunday, September 27 |
| » Lost to Cardinals (89-67), 5-0 | Forbes Field (42-39) | 77-78 | Lost 5 |
| » Starters: Roger Craig vs Vern Law | Sixth | 13 out |
| Tuesday, September 29 |
| » Defeated Reds (91-67), 2-0 | Crosley Field (4-3) | 78-78 | |
| » Starters: Bob Friend vs Billy McCool | Fifth | 12 out |
| Wednesday, September 30 |
| » Defeated Reds (91-68), 1-0 | Crosley Field (5-3) | 79-78 | Won 2 |
| » Starters: Bob Veale vs Jim Maloney | Sixth | 12 out |
| Thursday, October 1 |
| » Lost to Reds (92-68), 5-4 | Crosley Field (5-4) | 79-79 | |
| » Starters: Joe Gibbon vs Bob Purkey | Sixth | 12½ out |
| Friday, October 2 |
