| Saturday, January 18 |
| Future Oriole Brady Anderson is born in Silver Spring, MD. |
| Monday, January 20 |
| Future Oriole Ozzie Guillen is born in Oculare Del Tuy, Venezuela. |
| Wednesday, January 29 |
| Future Oriole John Habyan is born in Bay Shore, NY. |
| Friday, March 13 |
| Future Oriole Will Clark is born in New Orleans, LA. |
| Thursday, April 2 |
| Future Oriole Pete Incaviglia is born in Pebble Beach, CA. |
| Monday, April 13 |
| » Major-league debuts: Bobby Knoop (Angels) |
| Tuesday, April 14 |
| » Defeated White Sox (0-1), 5-3 | Comiskey Park I (1-0) | 1-0 | |
| » Starters: Milt Pappas vs Gary Peters | First | -- |
| Wednesday, April 15 |
| » Major-league debuts: Dick Kelley and Phil Niekro (Braves) |
| Thursday, April 16 |
| » Defeated White Sox (0-2), 4-3 | Comiskey Park I (2-0) | 2-0 | Won 2 |
| » Starters: Dave McNally vs Ray Herbert | First | -- |
| » Major-league debuts: Jerry McNertney (White Sox) |
| Friday, April 17 |
| » Defeated Yankees (0-2), 4-3 | Memorial Stadium (1-0) | 3-0 | Won 3 |
| » Starters: Jim Bouton vs Steve Barber | First | -- |
| » Major-league debuts: Pete Mikkelsen (Yankees) |
| Saturday, April 18 |
| » Defeated Yankees (0-3), 2-1 | Memorial Stadium (2-0) | 4-0 | Won 4 |
| » Starters: Al Downing vs Robin Roberts | First | -- |
| Sunday, April 19 |
| » Lost to Yankees (1-3), 5-3 | Memorial Stadium (2-1) | 4-1 | |
| » Starters: Bud Daley vs Milt Pappas | First | -- |
| Future Oriole Scott Kamieniecki is born in Mount Clemens, MI. |
| Thursday, April 23 |
| » Lost to Red Sox (4-2), 3-1 | Memorial Stadium (2-2) | 4-2 | Lost 2 |
| » Starters: Jack Lamabe vs Steve Barber | Second | 1½ out |
| » Defeated Red Sox (4-3), 1-0 | Memorial Stadium (3-2) | 5-2 | |
| » Starters: Dave Morehead vs Robin Roberts | Second | 1½ out |
| Saturday, April 25 |
| » Lost to Yankees (3-4), 4-1 | Yankee Stadium (0-1) | 5-3 | |
| » Starters: Milt Pappas vs Jim Bouton | Third | 1 out |
| Sunday, April 26 |
| » Lost to Yankees (4-4), 5-4 | Yankee Stadium (0-2) | 5-4 | Lost 2 |
| » Starters: Dave McNally vs Whitey Ford | Third | 1 out |
| Tuesday, April 28 |
| » Lost to Red Sox (5-6), 6-4 | Fenway Park (0-1) | 5-5 | Lost 3 |
| » Starters: Robin Roberts vs Jack Lamabe | Sixth | 1 out |
| Wednesday, April 29 |
| » Defeated Red Sox (5-7), 4-2 | Fenway Park (1-1) | 6-5 | |
| » Starters: Chuck Estrada vs Dave Morehead | Fourth | 1½ out |
| Thursday, April 30 |
| Future Oriole Jeff Reboulet is born in Dayton, OH. |
| Saturday, May 2 |
| » Lost to Indians (7-3), 6-4 | Memorial Stadium (3-3) | 6-6 | |
| » Starters: Jack Kralick vs Milt Pappas | Sixth | 2 out |
| Sunday, May 3 |
| » Defeated Indians (7-4), 5-2 | Memorial Stadium (4-3) | 7-6 | |
| » Starters: Tommy John vs Robin Roberts | Sixth | 2 out |
| » Lost to Indians (8-4), 3-0 | Memorial Stadium (4-4) | 7-7 | |
| » Starters: Mudcat Grant vs Dave McNally | Sixth | 2 out |
| Monday, May 4 |
| » Defeated Senators (8-11), 11-4 | Memorial Stadium (5-4) | 8-7 | |
| » Starters: Tom Cheney vs Chuck Estrada | Third | 2 out |
| Tuesday, May 5 |
| » Defeated Senators (8-12), 2-1 | Memorial Stadium (6-4) | 9-7 | Won 2 |
| » Starters: Jim Hannan vs Wally Bunker | Third | 1 out |
| Wednesday, May 6 |
| » Lost to Indians (10-5), 7-5 | Cleveland Stadium (0-1) | 9-8 | |
| » Starters: Mike McCormick vs Jack Kralick | Third | 2 out |
| Thursday, May 7 |
| » Lost to Indians (11-5), 9-4 | Cleveland Stadium (0-2) | 9-9 | Lost 2 |
| » Starters: Dave McNally vs Mudcat Grant | Fourth | 3 out |
| Friday, May 8 |
| » Defeated Tigers (9-10), 4-3 | Tiger Stadium (1-0) | 10-9 | |
| » Starters: Robin Roberts vs Mickey Lolich | Fourth | 2½ out |
| Saturday, May 9 |
| » Defeated Tigers (9-11), 7-6 | Tiger Stadium (2-0) | 11-9 | Won 2 |
| » Starters: Chuck Estrada vs Hank Aguirre | Third | 1½ out |
| Sunday, May 10 |
| » Defeated Tigers (9-12), 2-1 | Tiger Stadium (3-0) | 12-9 | Won 3 |
| » Starters: Milt Pappas vs Dave Wickersham | Third | 2 out |
| » Defeated Tigers (9-13), 7-1 | Tiger Stadium (4-0) | 13-9 | Won 4 |
| » Starters: Wally Bunker vs Ed Rakow | Third | 2 out |
| Monday, May 11 |
| » Lost to Senators (12-16), 6-4 | Robert F. Kennedy Stadium (0-1) | 13-10 | |
| » Starters: Mike McCormick vs Bennie Daniels | Fourth | 2½ out |
| Tuesday, May 12 |
| » Defeated Senators (12-17), 5-0 | Robert F. Kennedy Stadium (1-1) | 14-10 | |
| » Starters: Dave McNally vs Dave Stenhouse | Fourth | 2½ out |
| Thursday, May 14 |
| » Lost to Senators (13-17), 4-1 | Robert F. Kennedy Stadium (1-2) | 14-11 | |
| » Starters: Robin Roberts vs Buster Narum | Fourth | 2 out |
| Friday, May 15 |
| » Defeated Angels (12-16), 6-1 | Memorial Stadium (7-4) | 15-11 | |
| » Starters: Dean Chance vs Wally Bunker | Third | 2½ out |
| » Defeated Angels (12-17), 12-0 | Memorial Stadium (8-4) | 16-11 | Won 2 |
| » Starters: Bob Lee vs Milt Pappas | Third | 2½ out |
| Saturday, May 16 |
| » Defeated Angels (12-18), 5-1 | Memorial Stadium (9-4) | 17-11 | Won 3 |
| » Starters: Fred Newman vs Steve Barber | Third | 1½ out |
| Sunday, May 17 |
| » Lost to Angels (13-18), 9-4 | Memorial Stadium (9-5) | 17-12 | |
| » Starters: Ken McBride vs Dave McNally | Fourth | 2½ out |
| Tuesday, May 19 |
| » Defeated Athletics (11-19), 3-2 | Memorial Stadium (10-5) | 18-12 | |
| » Starters: Moe Drabowsky vs Robin Roberts | Second | 2½ out |
| Wednesday, May 20 |
| » Defeated Athletics (11-20), 8-3 | Memorial Stadium (11-5) | 19-12 | Won 2 |
| » Starters: Diego Segui vs Milt Pappas | Second | 3 out |
| Thursday, May 21 |
| » Defeated Athletics (11-21), 7-6 | Memorial Stadium (12-5) | 20-12 | Won 3 |
| » Starters: John O'Donoghue vs Wally Bunker | Second | 3½ out |
| Friday, May 22 |
| » Defeated Twins (18-15), 6-5 | Memorial Stadium (13-5) | 21-12 | Won 4 |
| » Starters: Jim Kaat vs Steve Barber | Second | 3½ out |
| Saturday, May 23 |
| » Lost to Twins (19-15), 5-1 | Memorial Stadium (13-6) | 21-13 | |
| » Starters: Lee Stange vs Dave McNally | Second | 3½ out |
| Sunday, May 24 |
| » Defeated Twins (19-16), 2-0 | Memorial Stadium (14-6) | 22-13 | |
| » Starters: Jim Roland vs Robin Roberts | Second | 3½ out |
| » Defeated Twins (19-17), 7-6 | Memorial Stadium (15-6) | 23-13 | Won 2 |
| » Starters: Dick Stigman vs Milt Pappas | Second | 3½ out |
| Monday, May 25 |
| » Lost to Tigers (17-19), 5-3 | Memorial Stadium (15-7) | 23-14 | |
| » Starters: Hank Aguirre vs Steve Barber | Second | 3½ out |
| Tuesday, May 26 |
| » Defeated Tigers (17-20), 2-1 | Memorial Stadium (16-7) | 24-14 | |
| » Starters: Mickey Lolich vs Wally Bunker | Second | 4 out |
| Wednesday, May 27 |
| » Lost to Tigers (18-20), 6-3 | Memorial Stadium (16-8) | 24-15 | |
| » Starters: Phil Regan vs Dave McNally | Second | 4½ out |
| Friday, May 29 |
| » Defeated Angels (16-27), 3-2 | Dodger Stadium (1-0) | 25-15 | |
| » Starters: Robin Roberts vs Dean Chance | Second | 4 out |
| Saturday, May 30 |
| » Defeated Angels (16-28), 6-0 | Dodger Stadium (2-0) | 26-15 | Won 2 |
| » Starters: Milt Pappas vs Ken McBride | Second | 4 out |
| Sunday, May 31 |
| » Defeated Angels (16-29), 2-1 | Dodger Stadium (3-0) | 27-15 | Won 3 |
| » Starters: Steve Barber vs Bo Belinsky | Second | 3½ out |
| Monday, June 1 |
| » Defeated Athletics (15-27), 8-4 | Municipal Stadium (1-0) | 28-15 | Won 4 |
| » Starters: Wally Bunker vs Aurelio Monteagudo | Second | 3½ out |
| Tuesday, June 2 |
| » Defeated Athletics (15-28), 4-0 | Municipal Stadium (2-0) | 29-15 | Won 5 |
| » Starters: Dave McNally vs Orlando Pena | First | -- |
| Wednesday, June 3 |
| » Defeated Athletics (15-29), 5-1 | Municipal Stadium (3-0) | 30-15 | Won 6 |
| » Starters: Robin Roberts vs Diego Segui | First | -- |
| Friday, June 5 |
| » Lost to Twins (27-21), 11-5 | Metropolitan Stadium (0-1) | 30-16 | |
| » Starters: Milt Pappas vs Lee Stange | Second | 3 out |
| Saturday, June 6 |
| » Defeated Twins (27-22), 2-1 | Metropolitan Stadium (1-1) | 31-16 | |
| » Starters: Steve Barber vs Dick Stigman | First | -- |
| Sunday, June 7 |
| » Lost to Twins (28-22), 5-2 | Metropolitan Stadium (1-2) | 31-17 | |
| » Starters: Wally Bunker vs Camilo Pascual | Second | 2½ out |
| Tuesday, June 9 |
| » Lost to White Sox (30-14), 9-5 | Comiskey Park I (2-1) | 31-18 | Lost 2 |
| » Starters: Dave McNally vs Juan Pizarro | Second | 2½ out |
| Wednesday, June 10 |
| » Lost to White Sox (31-14), 2-1 | Comiskey Park I (2-2) | 31-19 | Lost 3 |
| » Starters: Robin Roberts vs Gary Peters | Second | 2½ out |
| Thursday, June 11 |
| » Defeated White Sox (31-15), 3-1 | Comiskey Park I (3-2) | 32-19 | |
| » Starters: Milt Pappas vs Fred Talbot | Second | 2½ out |
| Friday, June 12 |
| » Lost to Red Sox (28-27), 7-3 | Fenway Park (1-2) | 32-20 | |
| » Starters: Steve Barber vs Dave Morehead | Second | 2 out |
| Saturday, June 13 |
| » Lost to Red Sox (29-27), 6-2 | Fenway Park (1-3) | 32-21 | Lost 2 |
| » Starters: Wally Bunker vs Earl Wilson | Second | 2 out |
| Sunday, June 14 |
| » Defeated Red Sox (29-28), 10-1 | Fenway Park (2-3) | 33-21 | |
| » Starters: Dave McNally vs Jack Lamabe | First | -- |
| » Defeated Red Sox (29-29), 8-1 | Fenway Park (3-3) | 34-21 | Won 2 |
| » Starters: Chuck Estrada vs Ed Connolly | First | -- |
| Monday, June 15 |
| » Lost to White Sox (32-20), 9-1 | Memorial Stadium (16-9) | 34-22 | |
| » Starters: Fred Talbot vs Robin Roberts | Second | 2 out |
| Tuesday, June 16 |
| » Lost to White Sox (33-20), 5-0 | Memorial Stadium (16-10) | 34-23 | Lost 2 |
| » Starters: Juan Pizarro vs Milt Pappas | Second | 2 out |
| » Defeated White Sox (33-21), 3-1 | Memorial Stadium (17-10) | 35-23 | |
| » Starters: Joe Horlen vs Steve Barber | Second | 2 out |
| Wednesday, June 17 |
| » Defeated White Sox (33-22), 6-1 | Memorial Stadium (18-10) | 36-23 | Won 2 |
| » Starters: John Buzhardt vs Wally Bunker | First | -- |
| Thursday, June 18 |
| » Lost to White Sox (34-22), 2-0 | Memorial Stadium (18-11) | 36-24 | |
| » Starters: Frank Kreutzer vs Dave McNally | Second | 2 out |
| Friday, June 19 |
| » Defeated Red Sox (31-32), 2-1 | Memorial Stadium (19-11) | 37-24 | |
| » Starters: Ed Connolly vs Robin Roberts | First | -- |
| » Defeated Red Sox (31-33), 6-5 | Memorial Stadium (20-11) | 38-24 | Won 2 |
| » Starters: Bill Spanswick vs Chuck Estrada | First | -- |
| Saturday, June 20 |
| » Defeated Red Sox (31-34), 11-5 | Memorial Stadium (21-11) | 39-24 | Won 3 |
| » Starters: Dave Morehead vs Milt Pappas | First | -- |
| Sunday, June 21 |
| » Lost to Red Sox (32-34), 9-6 | Memorial Stadium (21-12) | 39-25 | |
| » Starters: Earl Wilson vs Steve Barber | Second | 2 out |
| Tuesday, June 23 |
| » Defeated Yankees (38-24), 9-8 | Memorial Stadium (22-12) | 40-25 | |
| » Starters: Rollie Sheldon vs Wally Bunker | First | -- |
| Wednesday, June 24 |
| » Defeated Yankees (38-25), 7-4 | Memorial Stadium (23-12) | 41-25 | Won 2 |
| » Starters: Whitey Ford vs Robin Roberts | First | -- |
| Thursday, June 25 |
| » Defeated Yankees (38-26), 3-1 | Memorial Stadium (24-12) | 42-25 | Won 3 |
| » Starters: Jim Bouton vs Steve Barber | First | -- |
| Friday, June 26 |
| » Defeated Senators (29-43), 9-4 | Robert F. Kennedy Stadium (2-2) | 43-25 | Won 4 |
| » Starters: Dave McNally vs Buster Narum | First | -- |
| Saturday, June 27 |
| » Defeated Senators (29-44), 3-1 | Robert F. Kennedy Stadium (3-2) | 44-25 | Won 5 |
| » Starters: Milt Pappas vs Jim Hannan | First | -- |
| Sunday, June 28 |
| » Defeated Senators (29-45), 6-4 | Robert F. Kennedy Stadium (4-2) | 45-25 | Won 6 |
| » Starters: Wally Bunker vs Alan Koch | First | -- |
| Monday, June 29 |
| » Defeated Twins (38-35), 6-3 | Memorial Stadium (25-12) | 46-25 | Won 7 |
| » Starters: Camilo Pascual vs Robin Roberts | First | -- |
| Tuesday, June 30 |
| » Lost to Twins (39-35), 3-1 | Memorial Stadium (25-13) | 46-26 | |
| » Starters: Gerry Arrigo vs Steve Barber | First | -- |
| Wednesday, July 1 |
| » Defeated Angels (35-42), 4-2 | Memorial Stadium (26-13) | 47-26 | |
| » Starters: Dean Chance vs Dave McNally | First | -- |
| Thursday, July 2 |
| » Lost to Angels (36-42), 10-6 | Memorial Stadium (26-14) | 47-27 | |
| » Starters: Bob Meyer vs Milt Pappas | First | -- |
| Friday, July 3 |
| » Defeated Athletics (30-47), 4-0 | Memorial Stadium (27-14) | 48-27 | |
| » Starters: Orlando Pena vs Wally Bunker | First | -- |
| Saturday, July 4 |
| » Tied Athletics, 6-6 | Memorial Stadium (27-14) | 48-27 | |
| » Starters: Moe Drabowsky vs Robin Roberts | First | -- |
| Sunday, July 5 |
| » Lost to Athletics (31-47), 3-1 | Memorial Stadium (27-15) | 48-28 | |
| » Starters: John O'Donoghue vs Steve Barber | First | -- |
| Thursday, July 9 |
| » Defeated Indians (34-43), 4-3 | Cleveland Stadium (1-2) | 49-28 | |
| » Starters: Wally Bunker vs Dick Donovan | First | -- |
| » Defeated Indians (34-44), 2-1 | Cleveland Stadium (2-2) | 50-28 | Won 2 |
| » Starters: Milt Pappas vs Sam McDowell | First | -- |
| Friday, July 10 |
| » Lost to Indians (35-44), 8-0 | Cleveland Stadium (2-3) | 50-29 | |
| » Starters: Steve Barber vs Jack Kralick | First | -- |
| Saturday, July 11 |
| » Defeated Indians (35-45), 7-4 | Cleveland Stadium (3-3) | 51-29 | |
| » Starters: Dave McNally vs Tommy John | First | -- |
| Sunday, July 12 |
| » Defeated Tigers (41-41), 4-2 | Tiger Stadium (5-0) | 52-29 | Won 2 |
| » Starters: Robin Roberts vs Hank Aguirre | First | -- |
| » Lost to Tigers (42-41), 4-3 | Tiger Stadium (5-1) | 52-30 | |
| » Starters: Chuck Estrada vs Mickey Lolich | First | -- |
| Monday, July 13 |
| » Lost to Tigers (43-41), 4-3 | Tiger Stadium (5-2) | 52-31 | Lost 2 |
| » Starters: Wally Bunker vs Dave Wickersham | First | -- |
| Tuesday, July 14 |
| » Lost to Yankees (50-31), 4-3 | Yankee Stadium (0-3) | 52-32 | Lost 3 |
| » Starters: Milt Pappas vs Al Downing | First | -- |
| Wednesday, July 15 |
| » Lost to Yankees (51-31), 2-0 | Yankee Stadium (0-4) | 52-33 | Lost 4 |
| » Starters: Dave McNally vs Whitey Ford | Second | 1½ out |
| Thursday, July 16 |
| » Defeated Yankees (51-32), 6-1 | Yankee Stadium (1-4) | 53-33 | |
| » Starters: Steve Barber vs Jim Bouton | First | -- |
| Friday, July 17 |
| » Defeated Tigers (44-44), 5-0 | Memorial Stadium (28-15) | 54-33 | Won 2 |
| » Starters: Dave Wickersham vs Robin Roberts | First | -- |
| Saturday, July 18 |
| » Defeated Tigers (44-45), 6-1 | Memorial Stadium (29-15) | 55-33 | Won 3 |
| » Starters: Hank Aguirre vs Milt Pappas | First | -- |
| » Lost to Tigers (45-45), 3-0 | Memorial Stadium (29-16) | 55-34 | |
| » Starters: Mickey Lolich vs Dave Vineyard | First | -- |
| Sunday, July 19 |
| » Defeated Tigers (45-46), 5-4 | Memorial Stadium (30-16) | 56-34 | |
| » Starters: Denny McLain vs Wally Bunker | First | -- |
| Monday, July 20 |
| Future Oriole Mark Lee is born in Williston, ND. |
| Tuesday, July 21 |
| » Lost to Indians (40-50), 4-2 | Memorial Stadium (30-17) | 56-35 | |
| » Starters: Lee Stange vs Dave McNally | Second | 2 out |
| » Lost to Indians (41-50), 8-5 | Memorial Stadium (30-18) | 56-36 | Lost 2 |
| » Starters: Pedro Ramos vs Steve Barber | Second | 2 out |
| Wednesday, July 22 |
| » Lost to Indians (42-50), 7-4 | Memorial Stadium (30-19) | 56-37 | Lost 3 |
| » Starters: Dick Donovan vs Milt Pappas | Second | 2 out |
| Thursday, July 23 |
| » Defeated Indians (42-51), 7-1 | Memorial Stadium (31-19) | 57-37 | |
| » Starters: Sam McDowell vs Robin Roberts | Second | 2 out |
| Friday, July 24 |
| » Defeated Senators (37-63), 2-1 | Memorial Stadium (32-19) | 58-37 | Won 2 |
| » Starters: Buster Narum vs Wally Bunker | First | -- |
| » Defeated Senators (37-64), 7-2 | Memorial Stadium (33-19) | 59-37 | Won 3 |
| » Starters: Steve Ridzik vs Dave Vineyard | First | -- |
| Saturday, July 25 |
| » Defeated Senators (37-65), 5-4 | Memorial Stadium (34-19) | 60-37 | Won 4 |
| » Starters: Bennie Daniels vs Steve Barber | First | -- |
| Future Oriole Jose Bautista is born in Bani, D.R. |
| Sunday, July 26 |
| » Lost to Senators (38-65), 4-1 | Memorial Stadium (34-20) | 60-38 | |
| » Starters: Dave Stenhouse vs Dave McNally | Second | 1½ out |
| Monday, July 27 |
| » Major-league debuts: Dave Eilers (Braves) |
| Tuesday, July 28 |
| » Lost to Twins (49-51), 7-4 | Metropolitan Stadium (1-3) | 60-39 | Lost 2 |
| » Starters: Robin Roberts vs Jim Kaat | Second | 1 out |
| Future Oriole Bob Milacki is born in Trenton, NJ. |
| Wednesday, July 29 |
| » Defeated Twins (49-52), 4-3 | Metropolitan Stadium (2-3) | 61-39 | |
| » Starters: Milt Pappas vs Mudcat Grant | Second | 1 out |
| Thursday, July 30 |
| » Defeated Twins (49-53), 7-4 | Metropolitan Stadium (3-3) | 62-39 | Won 2 |
| » Starters: Dave Vineyard vs Gerry Arrigo | Second | 1½ out |
| Friday, July 31 |
| » Defeated Athletics (39-63), 6-1 | Municipal Stadium (4-0) | 63-39 | Won 3 |
| » Starters: Wally Bunker vs John O'Donoghue | Second | 2 out |
| » Lost to Athletics (40-63), 7-6 | Municipal Stadium (4-1) | 63-40 | |
| » Starters: Dave McNally vs Ted Bowsfield | Second | 2 out |
| Saturday, August 1 |
| » Defeated Athletics (40-64), 5-2 | Municipal Stadium (5-1) | 64-40 | |
| » Starters: Frank Bertaina vs Orlando Pena | Second | 2 out |
| » Major-league debuts: Frank Bertaina (Orioles) |
| Sunday, August 2 |
| » Defeated Athletics (40-65), 8-7 | Municipal Stadium (6-1) | 65-40 | Won 2 |
| » Starters: Robin Roberts vs Diego Segui | Second | 2 out |
| Monday, August 3 |
| » Defeated Angels (56-54), 7-0 | Dodger Stadium (4-0) | 66-40 | Won 3 |
| » Starters: Milt Pappas vs Bo Belinsky | Second | 2½ out |
| Tuesday, August 4 |
| » Lost to Angels (57-54), 5-0 | Dodger Stadium (4-1) | 66-41 | |
| » Starters: Dave Vineyard vs Don Lee | Second | 2½ out |
| Future Oriole B.J. Surhoff is born in Bronx, NY. |
| Wednesday, August 5 |
| » Lost to Angels (58-54), 1-0 | Dodger Stadium (4-2) | 66-42 | Lost 2 |
| » Starters: Wally Bunker vs Dean Chance | Second | 2½ out |
| Friday, August 7 |
| » Defeated Yankees (64-41), 2-0 | Yankee Stadium (2-4) | 67-42 | |
| » Starters: Steve Barber vs Jim Bouton | First | -- |
| Saturday, August 8 |
| » Defeated Yankees (64-42), 6-5 | Yankee Stadium (3-4) | 68-42 | Won 2 |
| » Starters: Milt Pappas vs Whitey Ford | First | -- |
| Sunday, August 9 |
| » Lost to Yankees (65-42), 2-1 | Yankee Stadium (3-5) | 68-43 | |
| » Starters: Dave McNally vs Al Downing | First | -- |
| » Defeated Yankees (65-43), 4-2 | Yankee Stadium (4-5) | 69-43 | |
| » Starters: Robin Roberts vs Stan Williams | First | -- |
| Tuesday, August 11 |
| » Defeated Red Sox (53-61), 8-7 | Memorial Stadium (35-20) | 70-43 | Won 2 |
| » Starters: Bob Heffner vs Wally Bunker | First | -- |
| Wednesday, August 12 |
| » Defeated Red Sox (53-62), 7-0 | Memorial Stadium (36-20) | 71-43 | Won 3 |
| » Starters: Ed Connolly vs Milt Pappas | First | -- |
| Thursday, August 13 |
| » Defeated Red Sox (53-63), 7-1 | Memorial Stadium (37-20) | 72-43 | Won 4 |
| » Starters: Bill Monbouquette vs Robin Roberts | First | -- |
| Friday, August 14 |
| » Defeated Yankees (67-46), 5-4 | Memorial Stadium (38-20) | 73-43 | Won 5 |
| » Starters: Rollie Sheldon vs Steve Barber | First | -- |
| Future Oriole Mark Leonard is born in Mountain View, CA. Future Oriole Tommy Shields is born in Fairfax, VA. |
| Saturday, August 15 |
| » Lost to Yankees (68-46), 8-1 | Memorial Stadium (38-21) | 73-44 | |
| » Starters: Jim Bouton vs Dave McNally | First | -- |
| Future Oriole Jeff Huson is born in Scottsdale, AZ. |
| Sunday, August 16 |
| » Lost to Yankees (69-46), 3-1 | Memorial Stadium (38-22) | 73-45 | Lost 2 |
| » Starters: Mel Stottlemyre vs Milt Pappas | First | -- |
| Tuesday, August 18 |
| » Defeated Red Sox (54-66), 5-2 | Fenway Park (4-3) | 74-45 | |
| » Starters: Robin Roberts vs Bill Monbouquette | First | -- |
| Wednesday, August 19 |
| » Lost to Red Sox (55-66), 4-3 | Fenway Park (4-4) | 74-46 | |
| » Starters: Wally Bunker vs Earl Wilson | First | -- |
| Thursday, August 20 |
| » Lost to Red Sox (56-66), 4-3 | Fenway Park (4-5) | 74-47 | Lost 2 |
| » Starters: Dave Vineyard vs Dave Morehead | Second | ½ out |
| Friday, August 21 |
| » Defeated White Sox (75-48), 4-2 | Comiskey Park I (4-2) | 75-47 | |
| » Starters: Milt Pappas vs Juan Pizarro | First | -- |
| Saturday, August 22 |
| » Defeated White Sox (75-49), 4-2 | Comiskey Park I (5-2) | 76-47 | Won 2 |
| » Starters: Frank Bertaina vs Joe Horlen | First | -- |
| Sunday, August 23 |
| » Defeated White Sox (75-50), 7-3 | Comiskey Park I (6-2) | 77-47 | Won 3 |
| » Starters: Wally Bunker vs Ray Herbert | First | -- |
| » Lost to White Sox (76-50), 3-1 | Comiskey Park I (6-3) | 77-48 | |
| » Starters: Steve Barber vs Gary Peters | First | -- |
| Future Oriole Jeff Manto is born in Bristol, PA. |
| Tuesday, August 25 |
| » Lost to Indians (61-66), 5-3 | Memorial Stadium (38-23) | 77-49 | Lost 2 |
| » Starters: Sam McDowell vs Milt Pappas | First | -- |
| Wednesday, August 26 |
| » Lost to Indians (62-66), 3-2 | Memorial Stadium (38-24) | 77-50 | Lost 3 |
| » Starters: Lee Stange vs Robin Roberts | First | -- |
| Friday, August 28 |
| » Lost to White Sox (79-52), 2-1 | Memorial Stadium (38-25) | 77-51 | Lost 4 |
| » Starters: Gary Peters vs Wally Bunker | First | -- |
| » Defeated White Sox (79-53), 8-3 | Memorial Stadium (39-25) | 78-51 | |
| » Starters: John Buzhardt vs Steve Barber | First | -- |
| Saturday, August 29 |
| » Defeated White Sox (79-54), 5-0 | Memorial Stadium (40-25) | 79-51 | Won 2 |
| » Starters: Juan Pizarro vs Milt Pappas | First | -- |
| Sunday, August 30 |
| » Lost to White Sox (80-54), 3-0 | Memorial Stadium (40-26) | 79-52 | |
| » Starters: Joe Horlen vs Robin Roberts | First | -- |
| Tuesday, September 1 |
| » Lost to Twins (67-66), 2-1 | Metropolitan Stadium (3-4) | 79-53 | Lost 2 |
| » Starters: Steve Barber vs Jim Kaat | First | -- |
| Wednesday, September 2 |
| » Defeated Twins (67-67), 2-0 | Metropolitan Stadium (4-4) | 80-53 | |
| » Starters: Milt Pappas vs Dick Stigman | First | -- |
| Thursday, September 3 |
| » Defeated Twins (67-68), 4-1 | Metropolitan Stadium (5-4) | 81-53 | Won 2 |
| » Starters: Wally Bunker vs Camilo Pascual | First | -- |
| Friday, September 4 |
| » Lost to Angels (71-69), 7-1 | Dodger Stadium (4-3) | 81-54 | |
| » Starters: Robin Roberts vs Fred Newman | First | -- |
| » Major-league debuts: Lou Piniella (Orioles) |
| Saturday, September 5 |
| » Lost to Angels (72-69), 1-0 | Dodger Stadium (4-4) | 81-55 | Lost 2 |
| » Starters: Steve Barber vs George Brunet | Second | 1 out |
| Sunday, September 6 |
| » Defeated Angels (72-70), 2-0 | Dodger Stadium (5-4) | 82-55 | |
| » Starters: Milt Pappas vs Barry Latman | Second | 1½ out |
| Monday, September 7 |
| » Defeated Athletics (50-89), 6-1 | Municipal Stadium (7-1) | 83-55 | Won 2 |
| » Starters: Wally Bunker vs Orlando Pena | First | -- |
| » Lost to Athletics (51-89), 6-1 | Municipal Stadium (7-2) | 83-56 | |
| » Starters: Dave McNally vs Bob Meyer | First | -- |
| Wednesday, September 9 |
| » Defeated Senators (55-87), 6-3 | Robert F. Kennedy Stadium (5-2) | 84-56 | |
| » Starters: Robin Roberts vs Buster Narum | First | -- |
| » Lost to Senators (56-87), 4-3 | Robert F. Kennedy Stadium (5-3) | 84-57 | |
| » Starters: Steve Barber vs Claude Osteen | First | -- |
| » Major-league debuts: Paul Blair (Orioles) |
| Thursday, September 10 |
| » Defeated Senators (56-88), 12-5 | Robert F. Kennedy Stadium (6-3) | 85-57 | |
| » Starters: Milt Pappas vs Frank Kreutzer | First | -- |
| Friday, September 11 |
| » Defeated Athletics (51-90), 5-2 | Memorial Stadium (41-26) | 86-57 | Won 2 |
| » Starters: John O'Donoghue vs Wally Bunker | First | -- |
| » Lost to Athletics (52-90), 8-0 | Memorial Stadium (41-27) | 86-58 | |
| » Starters: Blue Moon Odom vs Dave Vineyard | First | -- |
| Saturday, September 12 |
| » Defeated Athletics (52-91), 1-0 | Memorial Stadium (42-27) | 87-58 | |
| » Starters: Bob Meyer vs Frank Bertaina | First | -- |
| Sunday, September 13 |
| » Lost to Athletics (53-91), 7-5 | Memorial Stadium (42-28) | 87-59 | |
| » Starters: Diego Segui vs Steve Barber | First | -- |
| Monday, September 14 |
| » Defeated Twins (72-74), 4-3 | Memorial Stadium (43-28) | 88-59 | |
| » Starters: Mudcat Grant vs Milt Pappas | First | -- |
| Tuesday, September 15 |
| » Lost to Twins (73-74), 2-1 | Memorial Stadium (43-29) | 88-60 | |
| » Starters: Jim Kaat vs Robin Roberts | First | -- |
| Wednesday, September 16 |
| » Lost to Twins (74-74), 2-1 | Memorial Stadium (43-30) | 88-61 | Lost 2 |
| » Starters: Camilo Pascual vs Wally Bunker | First | -- |
| Friday, September 18 |
| » Defeated Angels (76-75), 10-8 | Memorial Stadium (44-30) | 89-61 | |
| » Starters: Barry Latman vs Milt Pappas | Second | 2 out |
| Sunday, September 20 |
| » Lost to Angels (77-75), 8-5 | Memorial Stadium (44-31) | 89-62 | |
| » Starters: Dean Chance vs Frank Bertaina | Second | 2 out |
| » Defeated Angels (77-76), 8-2 | Memorial Stadium (45-31) | 90-62 | |
| » Starters: George Brunet vs Wally Bunker | Second | 2 out |
| Tuesday, September 22 |
| » Lost to Tigers (79-73), 2-1 | Tiger Stadium (5-3) | 90-63 | |
| » Starters: Milt Pappas vs Hank Aguirre | Second | 2½ out |
| Wednesday, September 23 |
| » Lost to Tigers (80-73), 10-3 | Tiger Stadium (5-4) | 90-64 | Lost 2 |
| » Starters: Steve Barber vs Phil Regan | Second | 4 out |
| Thursday, September 24 |
| Future Oriole Rafael Palmeiro is born in Havana, Cuba. |
| Friday, September 25 |
| » Defeated Indians (76-78), 10-6 | Cleveland Stadium (4-3) | 91-64 | |
| » Starters: Wally Bunker vs Lee Stange | Second | 4 out |
| Saturday, September 26 |
| » Defeated Indians (76-79), 5-3 | Cleveland Stadium (5-3) | 92-64 | Won 2 |
| » Starters: Milt Pappas vs Luis Tiant | Second | 4 out |
| Sunday, September 27 |
| » Defeated Indians (76-80), 4-0 | Cleveland Stadium (6-3) | 93-64 | Won 3 |
| » Starters: Robin Roberts vs Sonny Siebert | Second | 3 out |
| Wednesday, September 30 |
| » Defeated Senators (61-97), 8-4 | Memorial Stadium (46-31) | 94-64 | Won 4 |
| » Starters: Buster Narum vs Wally Bunker | Third | 4 out |
| » Lost to Senators (62-97), 6-3 | Memorial Stadium (46-32) | 94-65 | |
| » Starters: Claude Osteen vs Milt Pappas | Third | 4 out |
| Thursday, October 1 |
| » Defeated Senators (62-98), 2-0 | Memorial Stadium (47-32) | 95-65 | |
| » Starters: Frank Kreutzer vs Dave McNally | Third | 2½ out |
| Friday, October 2 |
| » Defeated Tigers (85-76), 10-4 | Memorial Stadium (48-32) | 96-65 | Won 2 |
| » Starters: Joe Sparma vs Robin Roberts | Third | 2½ out |
| Saturday, October 3 |
| » Defeated Tigers (85-77), 7-6 | Memorial Stadium (49-32) | 97-65 | Won 3 |
| » Starters: Bill Faul vs Milt Pappas | Third | 2½ out |
| Sunday, October 4 |
| Future Oriole Mark McLemore is born in San Diego, CA. |
| Monday, October 5 |
| Future Oriole Terry Mathews is born in Alexandria, LA. |
| Saturday, December 5 |
| Future Oriole Gene Harris is born in Sebring, FL. |
| Wednesday, December 16 |
| Future Oriole Billy Ripken is born in Havre De Grace, MD. Future Oriole Billy Ripken is born in Havre De Grace, MD. |
| Saturday, December 19 |
| Future Oriole Mike Fetters is born in Van Nuys, CA. |
Game information provided by Retrosheet (www.retrosheet.org) |