| Friday, January 3 |
| Future Indian Russ Swan is born in Fremont, CA. |
| Wednesday, January 22 |
| Future Indian Wayne Kirby is born in Williamsburg, VA. |
| Wednesday, March 4 |
| Future Indian Tom Lampkin is born in Cincinnati, OH. |
| Friday, April 10 |
| Future Indian Eric King is born in Oxnard, CA. |
| Monday, April 13 |
| » Major-league debuts: Bobby Knoop (Angels) |
| Tuesday, April 14 |
| » Lost to Twins (1-0), 7-6 | Cleveland Stadium (0-1) | 0-1 | |
| » Starters: Camilo Pascual vs Mudcat Grant | Third | 1 out |
| Wednesday, April 15 |
| » Major-league debuts: Dick Kelley and Phil Niekro (Braves) |
| Thursday, April 16 |
| » Major-league debuts: Jerry McNertney (White Sox) |
| Friday, April 17 |
| » Defeated Athletics (0-2), 6-4 | Cleveland Stadium (1-1) | 1-1 | |
| » Starters: Diego Segui vs Jack Kralick | Fourth | 1½ out |
| Sunday, April 19 |
| Future Indian Scott Kamieniecki is born in Mount Clemens, MI. |
| Tuesday, April 21 |
| » Defeated Athletics (1-3), 5-3 | Municipal Stadium (1-0) | 2-1 | Won 2 |
| » Starters: Mudcat Grant vs Diego Segui | Third | 1 out |
| Thursday, April 23 |
| » Defeated Angels (3-4), 3-2 | Dodger Stadium (1-0) | 3-1 | Won 3 |
| » Starters: Dick Donovan vs Ken McBride | First | -- |
| Friday, April 24 |
| » Defeated Angels (3-5), 5-2 | Dodger Stadium (2-0) | 4-1 | Won 4 |
| » Starters: Pedro Ramos vs Barry Latman | First | -- |
| Saturday, April 25 |
| » Defeated Angels (3-6), 2-1 | Dodger Stadium (3-0) | 5-1 | Won 5 |
| » Starters: Jack Kralick vs Bob Lee | First | -- |
| Sunday, April 26 |
| » Lost to Angels (4-6), 7-0 | Dodger Stadium (3-1) | 5-2 | |
| » Starters: Mudcat Grant vs Fred Newman | First | -- |
| » Major-league debuts: Sonny Siebert (Indians) |
| Tuesday, April 28 |
| » Lost to Twins (7-5), 9-8 | Metropolitan Stadium (0-1) | 5-3 | Lost 2 |
| » Starters: Dick Donovan vs Jim Roland | First | -- |
| Thursday, April 30 |
| » Defeated Twins (7-6), 8-4 | Metropolitan Stadium (1-1) | 6-3 | |
| » Starters: Pedro Ramos vs Dick Stigman | First | -- |
| Saturday, May 2 |
| » Defeated Orioles (6-6), 6-4 | Memorial Stadium (1-0) | 7-3 | Won 2 |
| » Starters: Jack Kralick vs Milt Pappas | First | -- |
| Sunday, May 3 |
| » Lost to Orioles (7-6), 5-2 | Memorial Stadium (1-1) | 7-4 | |
| » Starters: Tommy John vs Robin Roberts | First | -- |
| » Defeated Orioles (7-7), 3-0 | Memorial Stadium (2-1) | 8-4 | |
| » Starters: Mudcat Grant vs Dave McNally | First | -- |
| Monday, May 4 |
| » Defeated Red Sox (6-9), 7-5 | Fenway Park (1-0) | 9-4 | Won 2 |
| » Starters: Dick Donovan vs Bill Spanswick | First | -- |
| Tuesday, May 5 |
| » Lost to Red Sox (7-9), 4-0 | Fenway Park (1-1) | 9-5 | |
| » Starters: Pedro Ramos vs Dave Morehead | First | -- |
| » Major-league debuts: Tom Kelley (Indians) |
| Wednesday, May 6 |
| » Defeated Orioles (9-8), 7-5 | Cleveland Stadium (2-1) | 10-5 | |
| » Starters: Mike McCormick vs Jack Kralick | First | -- |
| Thursday, May 7 |
| » Defeated Orioles (9-9), 9-4 | Cleveland Stadium (3-1) | 11-5 | Won 2 |
| » Starters: Dave McNally vs Mudcat Grant | First | -- |
| Friday, May 8 |
| » Lost to Yankees (10-7), 10-3 | Cleveland Stadium (3-2) | 11-6 | |
| » Starters: Ralph Terry vs Tommy John | Second | ½ out |
| Saturday, May 9 |
| » Lost to Yankees (11-7), 6-2 | Cleveland Stadium (3-3) | 11-7 | Lost 2 |
| » Starters: Whitey Ford vs Pedro Ramos | Second | ½ out |
| Sunday, May 10 |
| » Lost to Yankees (12-7), 12-2 | Cleveland Stadium (3-4) | 11-8 | Lost 3 |
| » Starters: Jim Bouton vs Dick Donovan | Fourth | 2 out |
| » Lost to Yankees (13-7), 3-2 | Cleveland Stadium (3-5) | 11-9 | Lost 4 |
| » Starters: Stan Williams vs Jack Kralick | Fourth | 2 out |
| Monday, May 11 |
| » Defeated Red Sox (10-13), 11-7 | Cleveland Stadium (4-5) | 12-9 | |
| » Starters: Jack Lamabe vs Tommy John | Third | 1½ out |
| Future Indian Bobby Witt is born in Arlington, VA. |
| Tuesday, May 12 |
| » Defeated Red Sox (10-14), 6-5 | Cleveland Stadium (5-5) | 13-9 | Won 2 |
| » Starters: Bill Spanswick vs Mudcat Grant | Third | 1½ out |
| Wednesday, May 13 |
| » Defeated Red Sox (10-15), 3-0 | Cleveland Stadium (6-5) | 14-9 | Won 3 |
| » Starters: Dave Morehead vs Dick Donovan | Third | 1½ out |
| Thursday, May 14 |
| Former Indian Dave Altizer dies in Pleasant Hill, IL at the age of 88. |
| Friday, May 15 |
| » Defeated Tigers (11-14), 10-6 | Tiger Stadium (1-0) | 15-9 | Won 4 |
| » Starters: Pedro Ramos vs Dave Wickersham | Second | 1 out |
| Former Indian Harley Boss dies in Nashville, TN at the age of 56. |
| Saturday, May 16 |
| » Defeated Tigers (11-15), 2-1 | Tiger Stadium (2-0) | 16-9 | Won 5 |
| » Starters: Jack Kralick vs Ed Rakow | First | -- |
| Sunday, May 17 |
| » Lost to Tigers (12-15), 3-1 | Tiger Stadium (2-1) | 16-10 | |
| » Starters: Tommy John vs Hank Aguirre | Third | 1½ out |
| » Lost to Tigers (13-15), 4-1 | Tiger Stadium (2-2) | 16-11 | Lost 2 |
| » Starters: Mudcat Grant vs Mickey Lolich | Third | 1½ out |
| Tuesday, May 19 |
| » Lost to White Sox (16-9), 6-5 | Comiskey Park I (0-1) | 16-12 | Lost 3 |
| » Starters: Sonny Siebert vs Gary Peters | Fourth | 1½ out |
| Friday, May 22 |
| » Defeated Tigers (15-18), 5-3 | Cleveland Stadium (7-5) | 17-12 | |
| » Starters: Mickey Lolich vs Jack Kralick | Third | 1½ out |
| Saturday, May 23 |
| » Defeated Tigers (15-19), 11-9 | Cleveland Stadium (8-5) | 18-12 | Won 2 |
| » Starters: Phil Regan vs Tommy John | Third | 1½ out |
| Sunday, May 24 |
| » Lost to Tigers (16-19), 7-5 | Cleveland Stadium (8-6) | 18-13 | |
| » Starters: Dave Wickersham vs Pedro Ramos | Third | 2 out |
| Tuesday, May 26 |
| » Lost to Yankees (19-14), 3-2 | Yankee Stadium (0-1) | 18-14 | Lost 2 |
| » Starters: Mudcat Grant vs Whitey Ford | Fourth | 3 out |
| Wednesday, May 27 |
| » Lost to Yankees (20-14), 7-2 | Yankee Stadium (0-2) | 18-15 | Lost 3 |
| » Starters: Jack Kralick vs Al Downing | Fifth | 3½ out |
| Friday, May 29 |
| » Lost to Senators (19-26), 8-4 | Robert F. Kennedy Stadium (0-1) | 18-16 | Lost 4 |
| » Starters: Tommy John vs Claude Osteen | Fifth | 4 out |
| Saturday, May 30 |
| » Defeated Senators (19-27), 10-2 | Robert F. Kennedy Stadium (1-1) | 19-16 | |
| » Starters: Pedro Ramos vs Buster Narum | Fifth | 4 out |
| Sunday, May 31 |
| » Defeated Senators (19-28), 9-6 | Robert F. Kennedy Stadium (2-1) | 20-16 | Won 2 |
| » Starters: Mudcat Grant vs Don Rudolph | Third | 4 out |
| » Defeated Senators (19-29), 8-3 | Robert F. Kennedy Stadium (3-1) | 21-16 | Won 3 |
| » Starters: Gary Bell vs Bennie Daniels | Third | 4 out |
| Monday, June 1 |
| » Defeated White Sox (24-12), 3-0 | Cleveland Stadium (9-6) | 22-16 | Won 4 |
| » Starters: Juan Pizarro vs Jack Kralick | Third | 3 out |
| Tuesday, June 2 |
| » Defeated White Sox (24-13), 3-2 | Cleveland Stadium (10-6) | 23-16 | Won 5 |
| » Starters: John Buzhardt vs Sam McDowell | Third | 3½ out |
| Wednesday, June 3 |
| » Lost to White Sox (25-13), 3-0 | Cleveland Stadium (10-7) | 23-17 | |
| » Starters: Joe Horlen vs Tommy John | Third | 4½ out |
| Thursday, June 4 |
| » Lost to White Sox (26-13), 5-1 | Cleveland Stadium (10-8) | 23-18 | Lost 2 |
| » Starters: Ray Herbert vs Dick Donovan | Third | 5 out |
| Friday, June 5 |
| » Lost to Senators (21-29), 5-3 | Cleveland Stadium (10-9) | 23-19 | Lost 3 |
| » Starters: Buster Narum vs Pedro Ramos | Fourth | 5 out |
| Saturday, June 6 |
| » Defeated Senators (21-30), 6-4 | Cleveland Stadium (11-9) | 24-19 | |
| » Starters: Bennie Daniels vs Jack Kralick | Third | 5 out |
| Sunday, June 7 |
| » Defeated Senators (21-31), 3-2 | Cleveland Stadium (12-9) | 25-19 | Won 2 |
| » Starters: Don Rudolph vs Sam McDowell | Fifth | 5 out |
| » Lost to Senators (22-31), 6-3 | Cleveland Stadium (12-10) | 25-20 | |
| » Starters: Alan Koch vs Gary Bell | Fifth | 5 out |
| Monday, June 8 |
| » Defeated Angels (20-33), 6-3 | Cleveland Stadium (13-10) | 26-20 | |
| » Starters: Barry Latman vs Sonny Siebert | Fourth | 4½ out |
| Tuesday, June 9 |
| » Lost to Angels (21-33), 5-1 | Cleveland Stadium (13-11) | 26-21 | |
| » Starters: Fred Newman vs Dick Donovan | Fourth | 5½ out |
| Wednesday, June 10 |
| » Lost to Angels (22-33), 7-4 | Cleveland Stadium (13-12) | 26-22 | Lost 2 |
| » Starters: Bo Belinsky vs Pedro Ramos | Fourth | 7 out |
| » Lost to Angels (23-33), 5-3 | Cleveland Stadium (13-13) | 26-23 | Lost 3 |
| » Starters: Don Lee vs Tommy John | Fourth | 7 out |
| Thursday, June 11 |
| » Lost to Angels (24-33), 5-4 | Cleveland Stadium (13-14) | 26-24 | Lost 4 |
| » Starters: Dean Chance vs Jack Kralick | Fifth | 7 out |
| Friday, June 12 |
| » Defeated Athletics (17-36), 3-0 | Cleveland Stadium (14-14) | 27-24 | |
| » Starters: Diego Segui vs Sam McDowell | Fifth | 5½ out |
| Saturday, June 13 |
| » Lost to Athletics (18-36), 5-4 | Cleveland Stadium (14-15) | 27-25 | |
| » Starters: Orlando Pena vs Sonny Siebert | Fifth | 5½ out |
| Sunday, June 14 |
| » Lost to Athletics (19-36), 6-5 | Cleveland Stadium (14-16) | 27-26 | Lost 2 |
| » Starters: Moe Drabowsky vs Dick Donovan | Fifth | 6½ out |
| » Lost to Athletics (20-36), 3-2 | Cleveland Stadium (14-17) | 27-27 | Lost 3 |
| » Starters: John O'Donoghue vs Tommy John | Fifth | 6½ out |
| Tuesday, June 16 |
| » Defeated Twins (32-27), 5-3 | Cleveland Stadium (15-17) | 28-27 | |
| » Starters: Dick Stigman vs Jack Kralick | Fifth | 5½ out |
| Wednesday, June 17 |
| » Defeated Twins (32-28), 3-2 | Cleveland Stadium (16-17) | 29-27 | Won 2 |
| » Starters: Camilo Pascual vs Sam McDowell | Fourth | 5 out |
| » Defeated Twins (32-29), 5-0 | Cleveland Stadium (17-17) | 30-27 | Won 3 |
| » Starters: Jim Roland vs Pedro Ramos | Fourth | 5 out |
| Friday, June 19 |
| » Lost to Angels (27-37), 2-1 | Dodger Stadium (3-2) | 30-28 | |
| » Starters: Dick Donovan vs Dean Chance | Fifth | 6 out |
| Saturday, June 20 |
| » Lost to Angels (28-37), 3-1 | Dodger Stadium (3-3) | 30-29 | Lost 2 |
| » Starters: Tommy John vs Fred Newman | Fifth | 7 out |
| Sunday, June 21 |
| » Lost to Angels (29-37), 4-1 | Dodger Stadium (3-4) | 30-30 | Lost 3 |
| » Starters: Jack Kralick vs Bo Belinsky | Fifth | 7 out |
| Monday, June 22 |
| » Tied Twins, 8-8 | Metropolitan Stadium (1-1) | 30-30 | |
| » Starters: Sam McDowell vs Camilo Pascual | Fifth | 7½ out |
| Tuesday, June 23 |
| » Lost to Twins (34-31), 6-2 | Metropolitan Stadium (1-2) | 30-31 | Lost 4 |
| » Starters: Pedro Ramos vs Jim Kaat | Fifth | 8 out |
| Wednesday, June 24 |
| » Defeated Twins (34-32), 12-3 | Metropolitan Stadium (2-2) | 31-31 | |
| » Starters: Dick Donovan vs Dick Stigman | Fifth | 8½ out |
| » Lost to Twins (35-32), 3-2 | Metropolitan Stadium (2-3) | 31-32 | |
| » Starters: Sam McDowell vs Jim Roland | Fifth | 8½ out |
| Thursday, June 25 |
| » Defeated Twins (35-33), 8-1 | Metropolitan Stadium (3-3) | 32-32 | |
| » Starters: Jack Kralick vs Mudcat Grant | Fifth | 8½ out |
| Friday, June 26 |
| » Lost to Red Sox (33-36), 3-2 | Fenway Park (1-2) | 32-33 | |
| » Starters: Tommy John vs Dave Morehead | Fifth | 9½ out |
| Saturday, June 27 |
| » Defeated Red Sox (33-37), 4-2 | Fenway Park (2-2) | 33-33 | |
| » Starters: Sonny Siebert vs Earl Wilson | Fifth | 9½ out |
| Sunday, June 28 |
| » Lost to Red Sox (34-37), 8-5 | Fenway Park (2-3) | 33-34 | |
| » Starters: Pedro Ramos vs Jack Lamabe | Sixth | 11 out |
| » Lost to Red Sox (35-37), 4-3 | Fenway Park (2-4) | 33-35 | Lost 2 |
| » Starters: Dick Donovan vs Bill Monbouquette | Sixth | 11 out |
| Monday, June 29 |
| » Lost to White Sox (38-29), 5-1 | Cleveland Stadium (17-18) | 33-36 | Lost 3 |
| » Starters: Gary Peters vs Sam McDowell | Sixth | 12 out |
| Tuesday, June 30 |
| » Lost to White Sox (39-29), 12-3 | Cleveland Stadium (17-19) | 33-37 | Lost 4 |
| » Starters: Juan Pizarro vs Jack Kralick | Sixth | 12 out |
| Wednesday, July 1 |
| » Lost to Tigers (33-38), 3-1 | Tiger Stadium (2-3) | 33-38 | Lost 5 |
| » Starters: Tommy John vs Hank Aguirre | Sixth | 13 out |
| Thursday, July 2 |
| » Lost to Tigers (34-38), 9-1 | Tiger Stadium (2-4) | 33-39 | Lost 6 |
| » Starters: Pedro Ramos vs Mickey Lolich | Eighth | 13 out |
| Friday, July 3 |
| » Defeated White Sox (41-30), 2-1 | Comiskey Park I (1-1) | 34-39 | |
| » Manager: Birdie Tebbetts |
| » Starters: Dick Donovan vs Fred Talbot | Eighth | 13 out |
| Saturday, July 4 |
| » Lost to White Sox (42-30), 4-0 | Comiskey Park I (1-2) | 34-40 | |
| » Starters: Sam McDowell vs Gary Peters | Eighth | 13½ out |
| Sunday, July 5 |
| » Lost to White Sox (43-30), 2-0 | Comiskey Park I (1-3) | 34-41 | Lost 2 |
| » Starters: Jack Kralick vs Juan Pizarro | Eighth | 14 out |
| » Lost to White Sox (44-30), 5-0 | Comiskey Park I (1-4) | 34-42 | Lost 3 |
| » Starters: Lee Stange vs Joe Horlen | Eighth | 14 out |
| Thursday, July 9 |
| » Lost to Orioles (49-28), 4-3 | Cleveland Stadium (17-20) | 34-43 | Lost 4 |
| » Starters: Wally Bunker vs Dick Donovan | Eighth | 16 out |
| » Lost to Orioles (50-28), 2-1 | Cleveland Stadium (17-21) | 34-44 | Lost 5 |
| » Starters: Milt Pappas vs Sam McDowell | Eighth | 16 out |
| Friday, July 10 |
| » Defeated Orioles (50-29), 8-0 | Cleveland Stadium (18-21) | 35-44 | |
| » Starters: Steve Barber vs Jack Kralick | Eighth | 15 out |
| Saturday, July 11 |
| » Lost to Orioles (51-29), 7-4 | Cleveland Stadium (18-22) | 35-45 | |
| » Starters: Dave McNally vs Tommy John | Eighth | 16 out |
| Sunday, July 12 |
| » Tied Yankees, 2-2 | Cleveland Stadium (18-22) | 35-45 | |
| » Starters: Stan Williams vs Pedro Ramos | Eighth | 16 out |
| Monday, July 13 |
| » Lost to Yankees (49-31), 10-4 | Cleveland Stadium (18-23) | 35-46 | Lost 2 |
| » Starters: Rollie Sheldon vs Dick Donovan | Eighth | 16 out |
| Tuesday, July 14 |
| » Defeated Athletics (32-54), 9-7 | Municipal Stadium (2-0) | 36-46 | |
| » Starters: Sam McDowell vs Diego Segui | Eighth | 15 out |
| Wednesday, July 15 |
| » Lost to Athletics (33-54), 5-3 | Municipal Stadium (2-1) | 36-47 | |
| » Starters: Jack Kralick vs Orlando Pena | Eighth | 16 out |
| » Lost to Athletics (34-54), 3-2 | Municipal Stadium (2-2) | 36-48 | Lost 2 |
| » Starters: Lee Stange vs Ted Bowsfield | Eighth | 16 out |
| Thursday, July 16 |
| » Defeated Athletics (34-55), 12-9 | Municipal Stadium (3-2) | 37-48 | |
| » Starters: Tommy John vs John O'Donoghue | Eighth | 15½ out |
| Friday, July 17 |
| » Lost to Yankees (52-32), 8-4 | Yankee Stadium (0-3) | 37-49 | |
| » Starters: Pedro Ramos vs Stan Williams | Eighth | 16½ out |
| Saturday, July 18 |
| » Defeated Yankees (52-33), 6-4 | Yankee Stadium (1-3) | 38-49 | |
| » Starters: Dick Donovan vs Al Downing | Eighth | 16 out |
| Sunday, July 19 |
| » Lost to Yankees (53-33), 6-2 | Yankee Stadium (1-4) | 38-50 | |
| » Starters: Sam McDowell vs Rollie Sheldon | Eighth | 16½ out |
| » Defeated Yankees (53-34), 3-0 | Yankee Stadium (2-4) | 39-50 | |
| » Starters: Luis Tiant vs Whitey Ford | Eighth | 16½ out |
| » Major-league debuts: Luis Tiant and Jr. (Indians) |
| Tuesday, July 21 |
| » Defeated Orioles (56-35), 4-2 | Memorial Stadium (3-1) | 40-50 | Won 2 |
| » Starters: Lee Stange vs Dave McNally | Eighth | 14½ out |
| » Defeated Orioles (56-36), 8-5 | Memorial Stadium (4-1) | 41-50 | Won 3 |
| » Starters: Pedro Ramos vs Steve Barber | Eighth | 14½ out |
| Wednesday, July 22 |
| » Defeated Orioles (56-37), 7-4 | Memorial Stadium (5-1) | 42-50 | Won 4 |
| » Starters: Dick Donovan vs Milt Pappas | Seventh | 14½ out |
| Thursday, July 23 |
| » Lost to Orioles (57-37), 7-1 | Memorial Stadium (5-2) | 42-51 | |
| » Starters: Sam McDowell vs Robin Roberts | Seventh | 14½ out |
| Friday, July 24 |
| » Defeated Red Sox (47-51), 6-1 | Cleveland Stadium (19-23) | 43-51 | |
| » Starters: Bob Heffner vs Luis Tiant | Eighth | 15 out |
| Saturday, July 25 |
| » Lost to Red Sox (48-51), 4-3 | Cleveland Stadium (19-24) | 43-52 | |
| » Starters: Bill Monbouquette vs Jack Kralick | Eighth | 16 out |
| Sunday, July 26 |
| » Lost to Red Sox (49-51), 6-1 | Cleveland Stadium (19-25) | 43-53 | Lost 2 |
| » Starters: Earl Wilson vs Lee Stange | Eighth | 17 out |
| » Lost to Red Sox (50-51), 3-1 | Cleveland Stadium (19-26) | 43-54 | Lost 3 |
| » Starters: Ed Connolly vs Pedro Ramos | Eighth | 17 out |
| Monday, July 27 |
| » Major-league debuts: Dave Eilers (Braves) |
| Tuesday, July 28 |
| » Lost to Senators (39-65), 4-3 | Robert F. Kennedy Stadium (3-2) | 43-55 | Lost 4 |
| » Starters: Luis Tiant vs Claude Osteen | Eighth | 17½ out |
| Future Indian Bob Milacki is born in Trenton, NJ. |
| Wednesday, July 29 |
| » Lost to Senators (40-65), 4-1 | Robert F. Kennedy Stadium (3-3) | 43-56 | Lost 5 |
| » Starters: Sam McDowell vs Buster Narum | Eighth | 18½ out |
| Former Indian Vean Gregg dies in Aberdeen, WA at the age of 80. |
| Thursday, July 30 |
| » Lost to Senators (41-65), 8-7 | Robert F. Kennedy Stadium (3-4) | 43-57 | Lost 6 |
| » Starters: Dick Donovan vs Alan Koch | Eighth | 19 out |
| Friday, July 31 |
| » Defeated Tigers (50-54), 12-3 | Cleveland Stadium (20-26) | 44-57 | |
| » Starters: Ed Rakow vs Jack Kralick | Eighth | 17½ out |
| » Defeated Tigers (50-55), 4-2 | Cleveland Stadium (21-26) | 45-57 | Won 2 |
| » Starters: Joe Sparma vs Pedro Ramos | Eighth | 17½ out |
| Saturday, August 1 |
| » Lost to Tigers (51-55), 2-1 | Cleveland Stadium (21-27) | 45-58 | |
| » Starters: Denny McLain vs Lee Stange | Eighth | 18½ out |
| Sunday, August 2 |
| » Defeated Tigers (51-56), 6-1 | Cleveland Stadium (22-27) | 46-58 | |
| » Starters: Hank Aguirre vs Sam McDowell | Eighth | 18 out |
| » Defeated Tigers (51-57), 2-1 | Cleveland Stadium (23-27) | 47-58 | Won 2 |
| » Starters: Mickey Lolich vs Jack Kralick | Eighth | 18 out |
| Monday, August 3 |
| » Defeated Senators (41-70), 4-2 | Cleveland Stadium (24-27) | 48-58 | Won 3 |
| » Starters: Frank Kreutzer vs Dick Donovan | Eighth | 17½ out |
| Tuesday, August 4 |
| » Lost to Senators (42-70), 4-2 | Cleveland Stadium (24-28) | 48-59 | |
| » Starters: Don Rudolph vs Pedro Ramos | Eighth | 17½ out |
| Wednesday, August 5 |
| » Defeated Senators (42-71), 9-0 | Cleveland Stadium (25-28) | 49-59 | |
| » Starters: Alan Koch vs Lee Stange | Eighth | 16½ out |
| Friday, August 7 |
| » Defeated Twins (53-56), 10-4 | Cleveland Stadium (26-28) | 50-59 | Won 2 |
| » Starters: Dick Stigman vs Luis Tiant | Eighth | 16½ out |
| » Defeated Twins (53-57), 8-2 | Cleveland Stadium (27-28) | 51-59 | Won 3 |
| » Starters: Jim Kaat vs Sam McDowell | Eighth | 16½ out |
| Saturday, August 8 |
| » Defeated Twins (53-58), 16-8 | Cleveland Stadium (28-28) | 52-59 | Won 4 |
| » Starters: Mudcat Grant vs Dick Donovan | Seventh | 16½ out |
| Sunday, August 9 |
| » Defeated Twins (53-59), 7-0 | Cleveland Stadium (29-28) | 53-59 | Won 5 |
| » Starters: Camilo Pascual vs Sonny Siebert | Seventh | 16½ out |
| » Lost to Twins (54-59), 3-1 | Cleveland Stadium (29-29) | 53-60 | |
| » Starters: Jim Kaat vs Lee Stange | Seventh | 16½ out |
| Tuesday, August 11 |
| » Defeated Angels (59-57), 3-0 | Dodger Stadium (4-4) | 54-60 | |
| » Starters: Luis Tiant vs Bo Belinsky | Seventh | 16½ out |
| Wednesday, August 12 |
| » Lost to Angels (60-57), 4-2 | Dodger Stadium (4-5) | 54-61 | |
| » Starters: Sam McDowell vs Fred Newman | Seventh | 17½ out |
| Friday, August 14 |
| » Lost to Twins (57-60), 7-6 | Metropolitan Stadium (3-4) | 54-62 | Lost 2 |
| » Starters: Lee Stange vs Jim Kaat | Seventh | 19 out |
| Saturday, August 15 |
| » Lost to Twins (58-60), 9-3 | Metropolitan Stadium (3-5) | 54-63 | Lost 3 |
| » Starters: Luis Tiant vs Dick Stigman | Seventh | 19 out |
| Sunday, August 16 |
| » Lost to Twins (59-60), 13-2 | Metropolitan Stadium (3-6) | 54-64 | Lost 4 |
| » Starters: Sonny Siebert vs Mudcat Grant | Sixth | 19 out |
| Tuesday, August 18 |
| » Lost to Athletics (44-74), 13-9 | Cleveland Stadium (29-30) | 54-65 | Lost 5 |
| » Starters: Jose Santiago vs Jack Kralick | Sixth | 19½ out |
| » Defeated Athletics (44-75), 5-1 | Cleveland Stadium (30-30) | 55-65 | |
| » Starters: Orlando Pena vs Luis Tiant | Sixth | 19½ out |
| Wednesday, August 19 |
| » Defeated Athletics (44-76), 6-4 | Cleveland Stadium (31-30) | 56-65 | Won 2 |
| » Starters: Diego Segui vs Sam McDowell | Seventh | 18½ out |
| Thursday, August 20 |
| » Lost to Athletics (45-76), 7-4 | Cleveland Stadium (31-31) | 56-66 | |
| » Starters: Bob Meyer vs Lee Stange | Sixth | 19 out |
| Friday, August 21 |
| Future Indian Shawn Hillegas is born in Dos Palos, CA. |
| Saturday, August 22 |
| » Defeated Angels (63-63), 1-0 | Cleveland Stadium (32-31) | 57-66 | |
| » Starters: Dean Chance vs Sonny Siebert | Seventh | 18½ out |
| » Defeated Angels (63-64), 5-1 | Cleveland Stadium (33-31) | 58-66 | Won 2 |
| » Starters: Don Lee vs Dick Donovan | Seventh | 18½ out |
| Sunday, August 23 |
| » Defeated Angels (63-65), 6-4 | Cleveland Stadium (34-31) | 59-66 | Won 3 |
| » Starters: Fred Newman vs Luis Tiant | Seventh | 17½ out |
| » Defeated Angels (63-66), 3-2 | Cleveland Stadium (35-31) | 60-66 | Won 4 |
| » Starters: Dan Osinski vs Jack Kralick | Seventh | 17½ out |
| Future Indian Jeff Manto is born in Bristol, PA. |
| Tuesday, August 25 |
| » Defeated Orioles (77-49), 5-3 | Memorial Stadium (6-2) | 61-66 | Won 5 |
| » Starters: Sam McDowell vs Milt Pappas | Seventh | 16½ out |
| Wednesday, August 26 |
| » Defeated Orioles (77-50), 3-2 | Memorial Stadium (7-2) | 62-66 | Won 6 |
| » Starters: Lee Stange vs Robin Roberts | Seventh | 15½ out |
| Friday, August 28 |
| » Defeated Athletics (48-81), 4-1 | Municipal Stadium (4-2) | 63-66 | Won 7 |
| » Starters: Sonny Siebert vs Orlando Pena | Seventh | 15 out |
| Saturday, August 29 |
| » Defeated Athletics (48-82), 4-3 | Municipal Stadium (5-2) | 64-66 | Won 8 |
| » Starters: Luis Tiant vs Moe Drabowsky | Sixth | 15 out |
| Sunday, August 30 |
| » Lost to Athletics (49-82), 9-3 | Municipal Stadium (5-3) | 64-67 | |
| » Starters: Jack Kralick vs John O'Donoghue | Seventh | 14½ out |
| » Defeated Athletics (49-83), 6-5 | Municipal Stadium (6-3) | 65-67 | |
| » Starters: Dick Donovan vs Bob Meyer | Seventh | 14½ out |
| Tuesday, September 1 |
| » Defeated Senators (53-82), 3-0 | Robert F. Kennedy Stadium (4-4) | 66-67 | Won 2 |
| » Starters: Sam McDowell vs Frank Kreutzer | Sixth | 13½ out |
| Future Indian Luis Lopez is born in Brooklyn, NY. |
| Wednesday, September 2 |
| » Defeated Senators (53-83), 9-0 | Robert F. Kennedy Stadium (5-4) | 67-67 | Won 3 |
| » Starters: Lee Stange vs Don Rudolph | Fifth | 13½ out |
| Friday, September 4 |
| » Lost to White Sox (82-55), 6-5 | Comiskey Park I (1-5) | 67-68 | |
| » Starters: Luis Tiant vs Juan Pizarro | Seventh | 14 out |
| Saturday, September 5 |
| » Lost to White Sox (83-55), 8-2 | Comiskey Park I (1-6) | 67-69 | Lost 2 |
| » Starters: Sonny Siebert vs Joe Horlen | Seventh | 15 out |
| » Major-league debuts: Vern Fuller (Indians) |
| Sunday, September 6 |
| » Defeated White Sox (83-56), 2-0 | Comiskey Park I (2-6) | 68-69 | |
| » Starters: Jack Kralick vs Gary Peters | Seventh | 15 out |
| » Lost to White Sox (84-56), 3-2 | Comiskey Park I (2-7) | 68-70 | |
| » Starters: Dick Donovan vs John Buzhardt | Seventh | 15 out |
| Monday, September 7 |
| » Defeated Tigers (74-67), 7-2 | Cleveland Stadium (36-31) | 69-70 | |
| » Starters: Denny McLain vs Sam McDowell | Seventh | 14 out |
| Future Indian Sergio Valdez is born in Elias Pina, D.R. |
| Wednesday, September 9 |
| » Lost to Red Sox (62-80), 6-5 | Cleveland Stadium (36-32) | 69-71 | |
| » Starters: Earl Wilson vs Luis Tiant | Seventh | 14½ out |
| Thursday, September 10 |
| » Defeated Red Sox (62-81), 5-4 | Cleveland Stadium (37-32) | 70-71 | |
| » Starters: Jack Lamabe vs Sonny Siebert | Seventh | 14½ out |
| Friday, September 11 |
| » Lost to White Sox (86-59), 7-3 | Cleveland Stadium (37-33) | 70-72 | |
| » Starters: Gary Peters vs Jack Kralick | Seventh | 15 out |
| Future Indian Ellis Burks is born in Vicksburg, MS. |
| Saturday, September 12 |
| » Defeated White Sox (86-60), 11-10 | Cleveland Stadium (38-33) | 71-72 | |
| » Starters: Ray Herbert vs Sam McDowell | Seventh | 15 out |
| Sunday, September 13 |
| » Defeated White Sox (86-61), 5-4 | Cleveland Stadium (39-33) | 72-72 | Won 2 |
| » Starters: Juan Pizarro vs Luis Tiant | Sixth | 14 out |
| Wednesday, September 16 |
| » Defeated Senators (57-91), 3-1 | Cleveland Stadium (40-33) | 73-72 | Won 3 |
| » Starters: Buster Narum vs Sonny Siebert | Fifth | 12½ out |
| » Defeated Senators (57-92), 3-2 | Cleveland Stadium (41-33) | 74-72 | Won 4 |
| » Starters: Frank Kreutzer vs Sam McDowell | Fifth | 12½ out |
| Friday, September 18 |
| » Defeated Tigers (77-72), 3-1 | Tiger Stadium (3-4) | 75-72 | Won 5 |
| » Starters: Jack Kralick vs Hank Aguirre | Fifth | 12½ out |
| Sunday, September 20 |
| » Lost to Tigers (78-72), 6-5 | Tiger Stadium (3-5) | 75-73 | |
| » Starters: Lee Stange vs Mickey Lolich | Fifth | 13½ out |
| » Defeated Tigers (78-73), 7-2 | Tiger Stadium (4-5) | 76-73 | |
| » Starters: Luis Tiant vs Dave Wickersham | Fifth | 13½ out |
| Tuesday, September 22 |
| » Lost to Yankees (90-59), 5-3 | Cleveland Stadium (41-34) | 76-74 | |
| » Starters: Mel Stottlemyre vs Sonny Siebert | Sixth | 15½ out |
| » Lost to Yankees (91-59), 8-1 | Cleveland Stadium (41-35) | 76-75 | Lost 2 |
| » Starters: Whitey Ford vs Dick Donovan | Sixth | 15½ out |
| » Major-league debuts: Duke Sims (Indians) |
| Wednesday, September 23 |
| » Lost to Yankees (92-59), 4-3 | Cleveland Stadium (41-36) | 76-76 | Lost 3 |
| » Starters: Al Downing vs Sam McDowell | Fifth | 17½ out |
| » Lost to Yankees (93-59), 6-4 | Cleveland Stadium (41-37) |
