| Friday, January 17 |
| Future Cardinal Jeff Tabaka is born in Barberton, OH. |
| Wednesday, January 29 |
| Future Cardinal John Habyan is born in Bay Shore, NY. |
| Wednesday, March 4 |
| Future Cardinal Tom Lampkin is born in Cincinnati, OH. |
| Friday, March 13 |
| Future Cardinal Will Clark is born in New Orleans, LA. |
| Saturday, March 28 |
| Future Cardinal Mike Fitzgerald is born in Savannah, GA. |
| Monday, April 13 |
| » Major-league debuts: Bobby Knoop (Angels) |
| Tuesday, April 14 |
| » Lost to Dodgers (1-0), 4-0 | Dodger Stadium (0-1) | 0-1 | |
| » Starters: Ernie Broglio vs Sandy Koufax | Second | 1 out |
| » Major-league debuts: Johnny Lewis (Cardinals) |
| Wednesday, April 15 |
| » Defeated Dodgers (1-1), 6-2 | Dodger Stadium (1-1) | 1-1 | |
| » Starters: Bob Gibson vs Don Drysdale | Third | 1 out |
| Thursday, April 16 |
| » Defeated Giants (2-1), 2-0 | Candlestick Park (1-0) | 2-1 | Won 2 |
| » Starters: Curt Simmons vs Bob Hendley | Second | ½ out |
| Friday, April 17 |
| » Lost to Giants (3-1), 5-4 | Candlestick Park (1-1) | 2-2 | |
| » Starters: Roger Craig vs Billy O'Dell | Fourth | 1½ out |
| Saturday, April 18 |
| » Defeated Giants (3-2), 3-2 | Candlestick Park (2-1) | 3-2 | |
| » Starters: Ernie Broglio vs Bobby Bolin | Second | ½ out |
| Sunday, April 19 |
| » Defeated Astros (2-3), 6-1 | Colt Stadium (1-0) | 4-2 | Won 2 |
| » Starters: Bob Gibson vs Don Nottebart | Second | ½ out |
| Monday, April 20 |
| » Lost to Astros (3-3), 7-1 | Colt Stadium (1-1) | 4-3 | |
| » Starters: Ray Sadecki vs Turk Farrell | Fourth | 1 out |
| Former Cardinal Eddie Dyer dies in Houston, TX at the age of 64. |
| Wednesday, April 22 |
| » Defeated Dodgers (1-7), 7-6 | Sportsman's Park III (1-0) | 5-3 | |
| » Starters: Sandy Koufax vs Curt Simmons | Fourth | 1½ out |
| Thursday, April 23 |
| » Lost to Dodgers (2-7), 7-5 | Sportsman's Park III (1-1) | 5-4 | |
| » Starters: Don Drysdale vs Ernie Broglio | Fourth | 1½ out |
| Friday, April 24 |
| » Defeated Astros (4-6), 3-2 | Sportsman's Park III (2-1) | 6-4 | |
| » Starters: Don Nottebart vs Bob Gibson | Fourth | 1½ out |
| Saturday, April 25 |
| » Lost to Astros (5-6), 4-2 | Sportsman's Park III (2-2) | 6-5 | |
| » Starters: Turk Farrell vs Roger Craig | Fifth | 1½ out |
| Sunday, April 26 |
| » Lost to Astros (6-6), 6-4 | Sportsman's Park III (2-3) | 6-6 | Lost 2 |
| » Starters: Jim Owens vs Curt Simmons | Fifth | 2½ out |
| Tuesday, April 28 |
| » Defeated Mets (2-9), 8-0 | Sportsman's Park III (3-3) | 7-6 | |
| » Starters: Al Jackson vs Ernie Broglio | Fourth | 2½ out |
| Wednesday, April 29 |
| » Defeated Mets (2-10), 4-3 | Sportsman's Park III (4-3) | 8-6 | Won 2 |
| » Starters: Jack Fisher vs Bob Gibson | Fourth | 2 out |
| Friday, May 1 |
| » Defeated Pirates (7-7), 6-2 | Sportsman's Park III (5-3) | 9-6 | Won 3 |
| » Starters: Vern Law vs Roger Craig | Third | 2½ out |
| Saturday, May 2 |
| » Lost to Pirates (8-7), 5-4 | Sportsman's Park III (5-4) | 9-7 | |
| » Starters: Bob Friend vs Curt Simmons | Fourth | 2½ out |
| Sunday, May 3 |
| » Lost to Pirates (9-7), 12-8 | Sportsman's Park III (5-5) | 9-8 | Lost 2 |
| » Starters: Bob Veale vs Ernie Broglio | Fourth | 2½ out |
| Monday, May 4 |
| » Defeated Phillies (10-5), 9-2 | Sportsman's Park III (6-5) | 10-8 | |
| » Starters: Dennis Bennett vs Bob Gibson | Fifth | 2½ out |
| Tuesday, May 5 |
| » Defeated Phillies (10-6), 2-1 | Sportsman's Park III (7-5) | 11-8 | Won 2 |
| » Starters: Jim Bunning vs Ray Washburn | Fourth | 2½ out |
| Wednesday, May 6 |
| » Lost to Pirates (11-8), 1-0 | Forbes Field (0-1) | 11-9 | |
| » Starters: Ray Sadecki vs Bob Friend | Fifth | 2½ out |
| Thursday, May 7 |
| » Defeated Pirates (11-9), 4-2 | Forbes Field (1-1) | 12-9 | |
| » Starters: Curt Simmons vs Bob Veale | Fourth | 2½ out |
| Friday, May 8 |
| » Lost to Mets (5-16), 5-4 | Shea Stadium (0-1) | 12-10 | |
| » Starters: Ernie Broglio vs Jack Fisher | Fourth | 3½ out |
| Saturday, May 9 |
| » Defeated Mets (5-17), 5-1 | Shea Stadium (1-1) | 13-10 | |
| » Starters: Bob Gibson vs Galen Cisco | Fourth | 3½ out |
| Sunday, May 10 |
| » Lost to Mets (6-17), 4-1 | Shea Stadium (1-2) | 13-11 | |
| » Starters: Roger Craig vs Tracy Stallard | Fourth | 3 out |
| » Defeated Mets (6-18), 10-1 | Shea Stadium (2-2) | 14-11 | |
| » Starters: Ray Washburn vs Jerry Hinsley | Fourth | 3 out |
| Monday, May 11 |
| » Defeated Phillies (14-8), 3-2 | Shibe Park (1-0) | 15-11 | Won 2 |
| » Starters: Ray Sadecki vs Ray Culp | Fourth | 2 out |
| Future Cardinal Bobby Witt is born in Arlington, VA. |
| Tuesday, May 12 |
| » Defeated Phillies (14-9), 4-2 | Shibe Park (2-0) | 16-11 | Won 3 |
| » Starters: Curt Simmons vs Art Mahaffey | Fourth | 2 out |
| Thursday, May 14 |
| » Lost to Phillies (15-9), 3-2 | Shibe Park (2-1) | 16-12 | |
| » Starters: Ernie Broglio vs Jim Bunning | Third | 1½ out |
| Friday, May 15 |
| » Defeated Braves (15-13), 10-6 | Sportsman's Park III (8-5) | 17-12 | |
| » Starters: Denny Lemaster vs Bob Gibson | Third | 2 out |
| Saturday, May 16 |
| » Defeated Braves (15-14), 6-5 | Sportsman's Park III (9-5) | 18-12 | Won 2 |
| » Starters: Bob Sadowski vs Ray Sadecki | Third | 1½ out |
| Sunday, May 17 |
| » Defeated Braves (15-15), 7-3 | Sportsman's Park III (10-5) | 19-12 | Won 3 |
| » Starters: Hank Fischer vs Curt Simmons | Third | 1½ out |
| » Lost to Braves (16-15), 4-2 | Sportsman's Park III (10-6) | 19-13 | |
| » Starters: Tony Cloninger vs Ray Washburn | Third | 1½ out |
| Tuesday, May 19 |
| » Lost to Cubs (12-16), 7-4 | Sportsman's Park III (10-7) | 19-14 | Lost 2 |
| » Starters: Dick Ellsworth vs Ernie Broglio | Third | 2 out |
| Wednesday, May 20 |
| » Defeated Cubs (12-17), 1-0 | Sportsman's Park III (11-7) | 20-14 | |
| » Starters: Larry Jackson vs Bob Gibson | Third | 2 out |
| Thursday, May 21 |
| » Defeated Cubs (12-18), 10-3 | Sportsman's Park III (12-7) | 21-14 | Won 2 |
| » Starters: Glen Hobbie vs Ray Sadecki | Third | 1 out |
| Friday, May 22 |
| » Defeated Braves (18-16), 6-1 | County Stadium (1-0) | 22-14 | Won 3 |
| » Starters: Curt Simmons vs Tony Cloninger | Third | 1 out |
| Saturday, May 23 |
| » Lost to Braves (19-16), 8-4 | County Stadium (1-1) | 22-15 | |
| » Starters: Roger Craig vs Hank Fischer | Third | 2 out |
| Sunday, May 24 |
| » Lost to Braves (20-16), 7-4 | County Stadium (1-2) | 22-16 | Lost 2 |
| » Starters: Ray Washburn vs Warren Spahn | Fourth | 2½ out |
| » Lost to Braves (21-16), 10-0 | County Stadium (1-3) | 22-17 | Lost 3 |
| » Starters: Ernie Broglio vs Denny Lemaster | Fourth | 2½ out |
| Tuesday, May 26 |
| Future Cardinal Willie Fraser is born in New York, NY. |
| Wednesday, May 27 |
| » Lost to Giants (23-15), 2-1 | Sportsman's Park III (12-8) | 22-18 | Lost 4 |
| » Starters: Juan Marichal vs Bob Gibson | Fourth | 2 out |
| Thursday, May 28 |
| » Lost to Giants (24-15), 2-1 | Sportsman's Park III (12-9) | 22-19 | Lost 5 |
| » Starters: Bob Hendley vs Curt Simmons | Fifth | 3 out |
| Friday, May 29 |
| » Defeated Reds (20-19), 4-3 | Sportsman's Park III (13-9) | 23-19 | |
| » Starters: Jim O'Toole vs Ray Sadecki | Fourth | 2 out |
| Saturday, May 30 |
| » Defeated Reds (20-20), 7-1 | Sportsman's Park III (14-9) | 24-19 | Won 2 |
| » Starters: Sammy Ellis vs Ernie Broglio | Third | 2 out |
| Sunday, May 31 |
| » Lost to Reds (21-20), 6-0 | Sportsman's Park III (14-10) | 24-20 | |
| » Starters: Bob Purkey vs Ray Washburn | Third | 2½ out |
| » Defeated Reds (21-21), 2-1 | Sportsman's Park III (15-10) | 25-20 | |
| » Starters: John Tsitouris vs Bob Gibson | Third | 2½ out |
| Tuesday, June 2 |
| » Lost to Cubs (20-22), 5-2 | Wrigley Field (0-1) | 25-21 | |
| » Starters: Curt Simmons vs Larry Jackson | Third | 3½ out |
| Wednesday, June 3 |
| » Defeated Cubs (20-23), 7-5 | Wrigley Field (1-1) | 26-21 | |
| » Starters: Ray Sadecki vs Bob Buhl | Third | 3½ out |
| Thursday, June 4 |
| » Lost to Cubs (21-23), 2-1 | Wrigley Field (1-2) | 26-22 | |
| » Starters: Bob Gibson vs Dick Ellsworth | Third | 3½ out |
| Friday, June 5 |
| » Lost to Reds (24-22), 5-4 | Crosley Field (0-1) | 26-23 | Lost 2 |
| » Starters: Glen Hobbie vs Bob Purkey | Fourth | 3½ out |
| Saturday, June 6 |
| » Lost to Reds (25-22), 3-0 | Crosley Field (0-2) | 26-24 | Lost 3 |
| » Starters: Ray Washburn vs John Tsitouris | Fifth | 4 out |
| Sunday, June 7 |
| » Lost to Reds (26-22), 11-6 | Crosley Field (0-3) | 26-25 | Lost 4 |
| » Starters: Curt Simmons vs Joe Nuxhall | Fifth | 5 out |
| Tuesday, June 9 |
| » Defeated Giants (30-20), 1-0 | Candlestick Park (3-1) | 27-25 | |
| » Starters: Ray Sadecki vs Juan Marichal | Fifth | 4 out |
| Wednesday, June 10 |
| » Lost to Giants (31-20), 3-0 | Candlestick Park (3-2) | 27-26 | |
| » Starters: Bob Gibson vs Bob Hendley | Fifth | 4 out |
| » Defeated Giants (31-21), 2-1 | Candlestick Park (4-2) | 28-26 | |
| » Starters: Glen Hobbie vs Ron Herbel | Fifth | 4 out |
| Thursday, June 11 |
| » Lost to Dodgers (26-28), 5-0 | Dodger Stadium (1-2) | 28-27 | |
| » Starters: Ray Washburn vs Don Drysdale | Fifth | 4 out |
| Friday, June 12 |
| » Lost to Dodgers (27-28), 3-0 | Dodger Stadium (1-3) | 28-28 | Lost 2 |
| » Starters: Ernie Broglio vs Sandy Koufax | Seventh | 4 out |
| Saturday, June 13 |
| » Lost to Dodgers (28-28), 3-2 | Dodger Stadium (1-4) | 28-29 | Lost 3 |
| » Starters: Ray Sadecki vs Joe Moeller | Seventh | 5 out |
| Sunday, June 14 |
| » Lost to Astros (27-32), 4-1 | Colt Stadium (1-2) | 28-30 | Lost 4 |
| » Starters: Bob Gibson vs Turk Farrell | Seventh | 6½ out |
| Monday, June 15 |
| » Lost to Astros (28-32), 9-3 | Colt Stadium (1-3) | 28-31 | Lost 5 |
| » Starters: Glen Hobbie vs Don Nottebart | Eighth | 7 out |
| Tuesday, June 16 |
| » Defeated Astros (28-33), 7-1 | Colt Stadium (2-3) | 29-31 | |
| » Starters: Curt Simmons vs Bob Bruce | Eighth | 7 out |
| Wednesday, June 17 |
| » Defeated Astros (28-34), 2-1 | Colt Stadium (3-3) | 30-31 | Won 2 |
| » Starters: Ray Washburn vs Ken Johnson | Sixth | 6 out |
| Thursday, June 18 |
| » Defeated Giants (35-25), 7-6 | Sportsman's Park III (16-10) | 31-31 | Won 3 |
| » Starters: Juan Marichal vs Ray Sadecki | Sixth | 6 out |
| » Major-league debuts: Hal Lanier (Giants) |
| Friday, June 19 |
| » Defeated Giants (35-26), 3-1 | Sportsman's Park III (17-10) | 32-31 | Won 4 |
| » Starters: Ron Herbel vs Bob Gibson | Fourth | 6½ out |
| Saturday, June 20 |
| » Lost to Giants (36-26), 14-3 | Sportsman's Park III (17-11) | 32-32 | |
| » Starters: Bob Hendley vs Glen Hobbie | Fourth | 6½ out |
| Sunday, June 21 |
| » Lost to Giants (37-26), 7-3 | Sportsman's Park III (17-12) | 32-33 | Lost 2 |
| » Starters: Jack Sanford vs Curt Simmons | Sixth | 8 out |
| Tuesday, June 23 |
| » Defeated Astros (32-35), 5-4 | Sportsman's Park III (18-12) | 33-33 | |
| » Starters: Turk Farrell vs Ray Washburn | Sixth | 7½ out |
| Wednesday, June 24 |
| » Lost to Astros (33-35), 7-5 | Sportsman's Park III (18-13) | 33-34 | |
| » Starters: Don Nottebart vs Ray Sadecki | Fifth | 8½ out |
| Thursday, June 25 |
| » Defeated Astros (33-36), 4-2 | Sportsman's Park III (19-13) | 34-34 | |
| » Starters: Bob Bruce vs Roger Craig | Fifth | 8 out |
| Friday, June 26 |
| » Lost to Phillies (41-24), 6-5 | Sportsman's Park III (19-14) | 34-35 | |
| » Starters: Jim Bunning vs Bob Gibson | Sixth | 9 out |
| Saturday, June 27 |
| » Defeated Phillies (41-25), 9-4 | Sportsman's Park III (20-14) | 35-35 | |
| » Starters: Dennis Bennett vs Curt Simmons | Sixth | 8 out |
| Sunday, June 28 |
| » Lost to Phillies (42-25), 5-0 | Sportsman's Park III (20-15) | 35-36 | |
| » Starters: Chris Short vs Mike Cuellar | Sixth | 8½ out |
| » Defeated Phillies (42-26), 8-2 | Sportsman's Park III (21-15) | 36-36 | |
| » Starters: Ray Culp vs Ray Sadecki | Sixth | 8½ out |
| Monday, June 29 |
| » Lost to Braves (35-37), 7-4 | Sportsman's Park III (21-16) | 36-37 | |
| » Starters: Dan Schneider vs Ray Washburn | Sixth | 8½ out |
| Tuesday, June 30 |
| » Lost to Braves (36-37), 5-4 | Sportsman's Park III (21-17) | 36-38 | Lost 2 |
| » Starters: Wade Blasingame vs Roger Craig | Seventh | 9½ out |
| Wednesday, July 1 |
| » Defeated Braves (36-38), 6-1 | County Stadium (2-3) | 37-38 | |
| » Starters: Curt Simmons vs Hank Fischer | Sixth | 9½ out |
| Thursday, July 2 |
| » Defeated Braves (36-39), 4-3 | County Stadium (3-3) | 38-38 | Won 2 |
| » Starters: Ray Sadecki vs Warren Spahn | Fifth | 9½ out |
| Future Cardinal Ozzie Canseco is born in Havana, Cuba. Future Cardinal Joe Magrane is born in Des Moines, IA. |
| Friday, July 3 |
| » Lost to Reds (41-34), 4-1 | Crosley Field (0-4) | 38-39 | |
| » Starters: Bob Gibson vs John Tsitouris | Fifth | 9½ out |
| Saturday, July 4 |
| » Lost to Reds (42-34), 3-2 | Crosley Field (0-5) | 38-40 | Lost 2 |
| » Starters: Mike Cuellar vs Jim O'Toole | Seventh | 10 out |
| Sunday, July 5 |
| » Defeated Reds (42-35), 3-1 | Crosley Field (1-5) | 39-40 | |
| » Starters: Roger Craig vs Joey Jay | Sixth | 10 out |
| Thursday, July 9 |
| » Lost to Mets (24-58), 4-3 | Shea Stadium (2-3) | 39-41 | |
| » Starters: Curt Simmons vs Al Jackson | Sixth | 11 out |
| Friday, July 10 |
| » Defeated Mets (24-59), 3-1 | Shea Stadium (3-3) | 40-41 | |
| » Starters: Bob Gibson vs Jack Fisher | Sixth | 10 out |
| Saturday, July 11 |
| » Defeated Mets (24-60), 11-4 | Shea Stadium (4-3) | 41-41 | Won 2 |
| » Starters: Ray Sadecki vs Tracy Stallard | Sixth | 9 out |
| Monday, July 13 |
| » Defeated Pirates (42-38), 5-4 | Forbes Field (2-1) | 42-41 | Won 3 |
| » Starters: Roger Craig vs Steve Blass | Fifth | 8½ out |
| » Defeated Pirates (42-39), 12-5 | Forbes Field (3-1) | 43-41 | Won 4 |
| » Starters: Mike Cuellar vs Vern Law | Fifth | 8½ out |
| Tuesday, July 14 |
| » Defeated Dodgers (41-43), 8-7 | Sportsman's Park III (22-17) | 44-41 | Won 5 |
| » Starters: Sandy Koufax vs Curt Simmons | Fifth | 7½ out |
| Wednesday, July 15 |
| » Lost to Dodgers (42-43), 13-3 | Sportsman's Park III (22-18) | 44-42 | |
| » Starters: Larry Miller vs Bob Gibson | Fifth | 7½ out |
| Thursday, July 16 |
| » Lost to Dodgers (43-43), 10-2 | Sportsman's Park III (22-19) | 44-43 | Lost 2 |
| » Starters: Joe Moeller vs Ray Sadecki | Sixth | 7½ out |
| Friday, July 17 |
| » Defeated Mets (26-64), 9-8 | Sportsman's Park III (23-19) | 45-43 | |
| » Starters: Galen Cisco vs Roger Craig | Sixth | 7½ out |
| Saturday, July 18 |
| » Defeated Mets (26-65), 15-7 | Sportsman's Park III (24-19) | 46-43 | Won 2 |
| » Starters: Al Jackson vs Glen Hobbie | Fifth | 6½ out |
| Sunday, July 19 |
| » Lost to Mets (27-65), 3-2 | Sportsman's Park III (24-20) | 46-44 | |
| » Starters: Jack Fisher vs Curt Simmons | Sixth | 6½ out |
| » Defeated Mets (27-66), 7-6 | Sportsman's Park III (25-20) | 47-44 | |
| » Starters: Frank Lary vs Bob Gibson | Sixth | 6½ out |
| Tuesday, July 21 |
| » Lost to Pirates (46-42), 8-4 | Sportsman's Park III (25-21) | 47-45 | |
| » Starters: Joe Gibbon vs Ray Sadecki | Sixth | 7 out |
| Wednesday, July 22 |
| » Lost to Pirates (47-42), 13-2 | Sportsman's Park III (25-22) | 47-46 | Lost 2 |
| » Starters: Bob Veale vs Roger Craig | Sixth | 8 out |
| Thursday, July 23 |
| » Lost to Pirates (48-42), 8-5 | Sportsman's Park III (25-23) | 47-47 | Lost 3 |
| » Starters: Don Schwall vs Mike Cuellar | Sixth | 9 out |
| » Major-league debuts: Ed Spiezio (Cardinals) |
| Friday, July 24 |
| » Lost to Phillies (56-37), 9-1 | Shibe Park (2-2) | 47-48 | Lost 4 |
| » Starters: Bob Gibson vs Chris Short | Seventh | 10 out |
| Saturday, July 25 |
| » Defeated Phillies (56-38), 10-9 | Shibe Park (3-2) | 48-48 | |
| » Starters: Curt Simmons vs Dennis Bennett | Sixth | 9 out |
| » Major-league debuts: Alex Johnson (Phillies) |
| Future Cardinal Jose Bautista is born in Bani, D.R. |
| Sunday, July 26 |
| » Defeated Phillies (56-39), 6-1 | Shibe Park (4-2) | 49-48 | Won 2 |
| » Starters: Gordie Richardson vs John Boozer | Sixth | 7 out |
| » Defeated Phillies (56-40), 4-1 | Shibe Park (5-2) | 50-48 | Won 3 |
| » Starters: Ray Sadecki vs Art Mahaffey | Sixth | 7 out |
| » Major-league debuts: Gary Kroll (Phillies) Gordie Richardson (Cardinals) |
| Tuesday, July 28 |
| » Defeated Cubs (48-49), 12-7 | Wrigley Field (2-2) | 51-48 | Won 4 |
| » Starters: Bob Gibson vs Ernie Broglio | Fifth | 7 out |
| Wednesday, July 29 |
| » Defeated Cubs (48-50), 9-1 | Wrigley Field (3-2) | 52-48 | Won 5 |
| » Starters: Curt Simmons vs Lew Burdette | Fifth | 6 out |
| Thursday, July 30 |
| » Defeated Cubs (48-51), 5-2 | Wrigley Field (4-2) | 53-48 | Won 6 |
| » Starters: Ray Sadecki vs Dick Ellsworth | Fifth | 6 out |
| Friday, July 31 |
| » Lost to Reds (56-47), 7-6 | Sportsman's Park III (25-24) | 53-49 | |
| » Starters: John Tsitouris vs Gordie Richardson | Sixth | 7 out |
| Saturday, August 1 |
| » Lost to Reds (57-47), 6-5 | Sportsman's Park III (25-25) | 53-50 | Lost 2 |
| » Starters: Joey Jay vs Bob Gibson | Sixth | 8 out |
| Sunday, August 2 |
| » Defeated Reds (57-48), 5-4 | Sportsman's Park III (26-25) | 54-50 | |
| » Starters: Jim Maloney vs Curt Simmons | Sixth | 7 out |
| Tuesday, August 4 |
| » Lost to Cubs (50-53), 4-0 | Sportsman's Park III (26-26) | 54-51 | |
| » Starters: Lew Burdette vs Ray Sadecki | Fifth | 7½ out |
| Wednesday, August 5 |
| » Defeated Cubs (50-54), 4-2 | Sportsman's Park III (27-26) | 55-51 | |
| » Starters: Bob Buhl vs Gordie Richardson | Fifth | 8 out |
| Thursday, August 6 |
| » Defeated Cubs (50-55), 5-3 | Sportsman's Park III (28-26) | 56-51 | Won 2 |
| » Starters: Dick Ellsworth vs Bob Gibson | Fifth | 7 out |
| Friday, August 7 |
| » Defeated Astros (47-65), 4-0 | Sportsman's Park III (29-26) | 57-51 | Won 3 |
| » Starters: Hal Brown vs Curt Simmons | Fifth | 7 out |
| Saturday, August 8 |
| » Lost to Astros (48-65), 4-3 | Sportsman's Park III (29-27) | 57-52 | |
| » Starters: Don Nottebart vs Ron Taylor | Fifth | 8 out |
| Sunday, August 9 |
| » Defeated Astros (48-66), 8-2 | Sportsman's Park III (30-27) | 58-52 | |
| » Starters: Bob Bruce vs Ray Sadecki | Fifth | 8 out |
| Monday, August 10 |
| » Defeated Giants (64-48), 2-1 | Sportsman's Park III (31-27) | 59-52 | Won 2 |
| » Starters: Ron Herbel vs Bob Gibson | Fifth | 7½ out |
| Tuesday, August 11 |
| » Lost to Giants (65-48), 6-3 | Sportsman's Park III (31-28) | 59-53 | |
| » Starters: Bob Hendley vs Curt Simmons | Fifth | 8½ out |
| Wednesday, August 12 |
| » Defeated Giants (65-49), 6-4 | Sportsman's Park III (32-28) | 60-53 | |
| » Starters: Gaylord Perry vs Roger Craig | Fifth | 8½ out |
| Friday, August 14 |
| » Defeated Dodgers (56-57), 4-3 | Dodger Stadium (2-4) | 61-53 | Won 2 |
| » Starters: Ray Sadecki vs Don Drysdale | Fifth | 8½ out |
| Saturday, August 15 |
| » Lost to Dodgers (57-57), 4-3 | Dodger Stadium (2-5) | 61-54 | |
| » Starters: Bob Gibson vs Joe Moeller | Fifth | 9½ out |
| Sunday, August 16 |
| » Lost to Dodgers (58-57), 3-0 | Dodger Stadium (2-6) | 61-55 | Lost 2 |
| » Starters: Gordie Richardson vs Sandy Koufax | Fifth | 9 out |
| » Defeated Dodgers (58-58), 4-0 | Dodger Stadium (3-6) | 62-55 | |
| » Starters: Curt Simmons vs Larry Miller | Fifth | 9 out |
| Monday, August 17 |
| » Defeated Astros (50-70), 3-1 | Colt Stadium (4-3) | 63-55 | Won 2 |
| » Starters: Roger Craig vs Hal Brown | Fifth | 9 out |
| Tuesday, August 18 |
| » Defeated Astros (50-71), 5-2 | Colt Stadium (5-3) | 64-55 | Won 3 |
| » Starters: Ray Sadecki vs Don Larsen | Fourth | 8 out |
| Wednesday, August 19 |
| » Lost to Astros (51-71), 8-7 | Colt Stadium (5-4) | 64-56 | |
| » Starters: Bob Gibson vs Don Nottebart | Fourth | 9 out |
| Friday, August 21 |
| » Defeated Giants (67-55), 6-5 | Candlestick Park (5-2) | 65-56 | |
| » Starters: Curt Simmons vs Bob Hendley | Fourth | 10 out |
| Saturday, August 22 |
| » Lost to Giants (68-55), 4-2 | Candlestick Park (5-3) | 65-57 | |
| » Starters: Roger Craig vs Bobby Bolin | Fourth | 10 out |
| Sunday, August 23 |
| » Lost to Giants (69-55), 3-2 | Candlestick Park (5-4) | 65-58 | Lost 2 |
| » Starters: Ray Sadecki vs Gaylord Perry | Third | 11 out |
| Monday, August 24 |
| » Defeated Pirates (64-61), 5-1 | Sportsman's Park III (33-28) | 66-58 | |
| » Starters: Bob Friend vs Bob Gibson | Fourth | 10 out |
| Tuesday, August 25 |
| » Defeated Pirates (64-62), 7-6 | Sportsman's Park III (34-28) | 67-58 | Won 2 |
| » Starters: Bob Veale vs Curt Simmons | Fourth | 9 out |
| Wednesday, August 26 |
| » Defeated Pirates (64-63), 4-2 | Sportsman's Park III (35-28) | 68-58 | Won 3 |
| » Starters: Frank Bork vs Mike Cuellar | Fourth | 9 out |
| Friday, August 28 |
| » Defeated Dodgers (62-64), 5-3 | Sportsman's Park III (36-28) | 69-58 | Won 4 |
| » Starters: Phil Ortega vs Ray Sadecki | Fourth | 8 out |
| Saturday, August 29 |
| » Defeated Dodgers (62-65), 4-1 | Sportsman's Park III (37-28) | 70-58 | Won 5 |
| » Starters: Howie Reed vs Bob Gibson | Fourth | 8 out |
| Sunday, August 30 |
| » Defeated Dodgers (62-66), 5-1 | Sportsman's Park III (38-28) | 71-58 | Won 6 |
| » Starters: Larry Miller vs Curt Simmons | Fourth | 7 out |
| Monday, August 31 |
| » Lost to Dodgers (63-66), 12-3 | Sportsman's Park III (38-29) | 71-59 | |
| » Starters: Don Drysdale vs Mike Cuellar | Fourth | 7½ out |
| Tuesday, September 1 |
| » Defeated Braves (66-65), 5-4 | Sportsman's Park III (39-29) | 72-59 | |
| » Starters: Denny Lemaster vs Ray Sadecki | Third | 7½ out |
| Wednesday, September 2 |
| » Defeated Braves (66-66), 6-2 | Sportsman's Park III (40-29) | 73-59 | Won 2 |
| » Starters: Hank Fischer vs Bob Gibson | Third | 7½ out |
| » Major-league debuts: Clay Carroll (Braves) |
| Thursday, September 3 |
| » Lost to Braves (67-66), 7-0 | Sportsman's Park III (40-30) | 73-60 | |
| » Starters: Wade Blasingame vs Roger Craig | Fourth | 7½ out |
| Friday, September 4 |
| » Defeated Cubs (61-73), 8-5 | Sportsman's Park III (41-30) | 74-60 | |
| » Starters: Dick Ellsworth vs Curt Simmons | Third | 7½ out |
| Saturday, September 5 |
| » Lost to Cubs (62-73), 8-5 | Sportsman's Park III (41-31) | 74-61 | |
| » Starters: Larry Jackson vs Mike Cuellar | Third | 8½ out |
| Sunday, September 6 |
| » Defeated Cubs (62-74), 5-4 | Sportsman's Park III (42-31) | 75-61 | |
| » Starters: Ernie Broglio vs Ray Sadecki | Fourth | 7½ out |
| Monday, September 7 |
| » Defeated Reds (77-60), 3-2 | Sportsman's Park III (43-31) | 76-61 | Won 2 |
| » Starters: Jim O'Toole vs Bob Gibson | Second | 6½ out |
| » Defeated Reds (77-61), 3-2 | Sportsman's Park III (44-31) | 77-61 | Won 3 |
| » Starters: John Tsitouris vs Roger Craig | Second | 6½ out |
| Wednesday, September 9 |
| » Defeated Phillies (83-56), 10-5 | Shibe Park (6-2) | 78-61 | Won 4 |
| » Starters: Curt Simmons vs Jim Bunning | Second | 5 out |
| Thursday, September 10 |
| » Lost to Phillies (84-56), 5-1 | Shibe Park (6-3) | 78-62 | |
| » Starters: Ray Sadecki vs Chris Short | Second | 6 out |
| Friday, September 11 |
| » Defeated Cubs (64-77), 5-0 | Wrigley Field (5-2) | 79-62 | |
| » Starters: Bob Gibson vs Ernie Broglio | Second | 6 out |
| Saturday, September 12 |
| » Lost to Cubs (65-77), 3-2 | Wrigley Field (5-3) | 79-63 | |
| » Starters: Roger Craig vs Bob Buhl | Third | 6 out |
| Sunday, September 13 |
| » Defeated Cubs (65-78), 15-2 | Wrigley Field (6-3) | 80-63 | |
| » Starters: Curt Simmons vs Dick Ellsworth | Second | 6 out |
| Tuesday, September 15 |
| » Defeated Braves (74-70), 11-6 | County Stadium (4-3) | 81-63 | Won 2 |
| » Starters: Ray Sadecki vs Tony Cloninger | Second | 6 out |
| » Defeated Braves (74-71), 3-1 | County Stadium (5-3) | 82-63 | Won 3 |
| » Starters: Bob Gibson vs Wade Blasingame | Second | 6 out |
| Wednesday, September 16 |
| » Lost to Braves (75-71), 3-2 | County Stadium (5-4) | 82-64 | |
| » Starters: Ron Taylor vs Denny Lemaster | Second | 6 out |
| Saturday, September 19 |
| » Lost to Reds (82-65), 7-5 | Crosley Field (1-6) | 82-65 | Lost 2 |
| » Starters: Bob Gibson vs Bob Purkey | Second | 5½ out |
| » Defeated Reds (82-66), 2-0 | Crosley Field (2-6) | 83-65 | |
| » Starters: Ray Sadecki vs Billy McCool | Second | 5½ out |
| Sunday, September 20 |
| » Lost to Reds (83-66), 9-6 | Crosley Field (2-7) | 83-66 | |
| » Starters: Gordie Richardson vs Joe Nuxhall | Second | 6½ out |
| Tuesday, September 22 |
| » Defeated Mets (50-100), 2-1 | Shea Stadium (5-3) | 84-66 | |
| » Starters: Curt Simmons vs Tracy Stallard | Third | 5 out |
| Wednesday, September 23 |
| » Lost to Mets (51-100), 2-1 | Shea Stadium (5-4) | 84-67 | |
| » Starters: Roger Craig vs Galen Cisco | Fourth | 5 out |
| Thursday, September 24 |
| » Defeated Pirates (77-74), 4-2 | Forbes Field (4-1) | 85-67 | |
| » Starters: Bob Gibson vs Wilbur Wood | Third | 3½ out |
| » Defeated Pirates (77-75), 4-0 | Forbes Field (5-1) | 86-67 | Won 2 |
| » Starters: Ray Sadecki vs Tom Butters | Third | 3½ out |
| Friday, September 25 |
| » Defeated Pirates (77-76), 5-3 | Forbes Field (6-1) | 87-67 | Won 3 |
| » Starters: Gordie Richardson vs Don Cardwell | Third | 2½ out |
| Saturday, September 26 |
| » Defeated Pirates (77-77), 6-3 | Forbes Field (7-1) | 88-67 | Won 4 |
| » Starters: Curt Simmons vs Bob Veale | Third | 1½ out |
| Sunday, September 27 |
| » Defeated Pirates (77-78), 5-0 | Forbes Field (8-1) |
