| Thursday, January 9 |
| Future Athletic Stan Javier is born in San Francisco De Macoris, D.R. |
| Wednesday, February 12 |
| Future Athletic Joe Bitker is born in Glendale, CA. |
| Thursday, February 13 |
| Future Athletic Dann Howitt is born in Battle Creek, MI. |
| Monday, April 13 |
| » Major-league debuts: Bobby Knoop (Angels) |
| Tuesday, April 14 |
| » Lost to Tigers (1-0), 7-3 | Tiger Stadium (0-1) | 0-1 | |
| » Starters: Orlando Pena vs Phil Regan | Third | 1 out |
| » Major-league debuts: Vern Handrahan (Athletics) |
| Wednesday, April 15 |
| » Major-league debuts: Dick Kelley and Phil Niekro (Braves) |
| Friday, April 17 |
| » Lost to Indians (1-1), 6-4 | Cleveland Stadium (0-1) | 0-2 | Lost 2 |
| » Starters: Diego Segui vs Jack Kralick | Sixth | 2½ out |
| Sunday, April 19 |
| » Defeated Senators (2-4), 5-1 | Robert F. Kennedy Stadium (1-0) | 1-2 | |
| » Starters: Orlando Pena vs Claude Osteen | Seventh | 2 out |
| Tuesday, April 21 |
| » Lost to Indians (2-1), 5-3 | Municipal Stadium (0-1) | 1-3 | |
| » Starters: Mudcat Grant vs Diego Segui | Seventh | 2½ out |
| Friday, April 24 |
| » Lost to Senators (4-5), 6-1 | Municipal Stadium (0-2) | 1-4 | Lost 2 |
| » Starters: Claude Osteen vs Orlando Pena | Tenth | 3 out |
| Saturday, April 25 |
| » Defeated Senators (4-6), 3-1 | Municipal Stadium (1-2) | 2-4 | |
| » Starters: Tom Cheney vs Moe Drabowsky | Ninth | 3 out |
| Sunday, April 26 |
| » Lost to Senators (5-6), 7-4 | Municipal Stadium (1-3) | 2-5 | |
| » Starters: Bennie Daniels vs Lew Krausse | Eighth | 3 out |
| Tuesday, April 28 |
| » Defeated Tigers (6-5), 5-1 | Municipal Stadium (2-3) | 3-5 | |
| » Starters: Frank Lary vs Diego Segui | Tenth | 2 out |
| Wednesday, April 29 |
| » Lost to Tigers (7-5), 5-4 | Municipal Stadium (2-4) | 3-6 | |
| » Starters: Hank Aguirre vs John O'Donoghue | Ninth | 2½ out |
| Thursday, April 30 |
| » Defeated Tigers (7-6), 10-3 | Municipal Stadium (3-4) | 4-6 | |
| » Starters: Mickey Lolich vs Orlando Pena | Ninth | 2½ out |
| Friday, May 1 |
| » Lost to Twins (8-6), 10-5 | Municipal Stadium (3-5) | 4-7 | |
| » Starters: Camilo Pascual vs Moe Drabowsky | Ninth | 3 out |
| Saturday, May 2 |
| » Lost to Twins (9-6), 7-3 | Municipal Stadium (3-6) | 4-8 | Lost 2 |
| » Starters: Lee Stange vs Aurelio Monteagudo | Tenth | 4 out |
| Sunday, May 3 |
| » Defeated Twins (9-7), 7-4 | Municipal Stadium (4-6) | 5-8 | |
| » Starters: Jim Kaat vs Diego Segui | Ninth | 3 out |
| » Defeated Twins (9-8), 8-7 | Municipal Stadium (5-6) | 6-8 | Won 2 |
| » Starters: Dick Stigman vs John O'Donoghue | Ninth | 3 out |
| Monday, May 4 |
| » Defeated Angels (7-10), 7-4 | Municipal Stadium (6-6) | 7-8 | Won 3 |
| » Starters: Bob Lee vs Orlando Pena | Sixth | 3 out |
| Tuesday, May 5 |
| » Lost to Angels (8-10), 8-1 | Municipal Stadium (6-7) | 7-9 | |
| » Starters: Barry Latman vs Vern Handrahan | Eighth | 3 out |
| Wednesday, May 6 |
| » Lost to White Sox (9-5), 6-4 | Comiskey Park I (0-1) | 7-10 | Lost 2 |
| » Starters: Moe Drabowsky vs Gary Peters | Seventh | 4½ out |
| » Lost to White Sox (10-5), 11-4 | Comiskey Park I (0-2) | 7-11 | Lost 3 |
| » Starters: Aurelio Monteagudo vs Ray Herbert | Seventh | 4½ out |
| Friday, May 8 |
| » Defeated Twins (10-11), 6-5 | Metropolitan Stadium (1-0) | 8-11 | |
| » Starters: Diego Segui vs Gerry Arrigo | Eighth | 4½ out |
| Saturday, May 9 |
| » Lost to Twins (11-11), 10-8 | Metropolitan Stadium (1-1) | 8-12 | |
| » Starters: Orlando Pena vs Lee Stange | Seventh | 4½ out |
| Sunday, May 10 |
| » Lost to Twins (12-11), 6-3 | Metropolitan Stadium (1-2) | 8-13 | Lost 2 |
| » Starters: Aurelio Monteagudo vs Camilo Pascual | Tenth | 5½ out |
| Monday, May 11 |
| » Lost to Angels (11-13), 6-5 | Dodger Stadium (0-1) | 8-14 | Lost 3 |
| » Starters: Moe Drabowsky vs Fred Newman | Tenth | 6 out |
| Future Athletic Bobby Witt is born in Arlington, VA. |
| Tuesday, May 12 |
| » Defeated Angels (11-14), 6-2 | Dodger Stadium (1-1) | 9-14 | |
| » Starters: John O'Donoghue vs Ken McBride | Tenth | 5 out |
| Wednesday, May 13 |
| » Lost to Angels (12-14), 9-0 | Dodger Stadium (1-2) | 9-15 | |
| » Starters: Aurelio Monteagudo vs Barry Latman | Ninth | 5½ out |
| » Defeated Angels (12-15), 2-0 | Dodger Stadium (2-2) | 10-15 | |
| » Starters: Orlando Pena vs Bo Belinsky | Ninth | 5½ out |
| Friday, May 15 |
| » Defeated Yankees (13-10), 11-0 | Yankee Stadium (1-0) | 11-15 | Won 2 |
| » Starters: Diego Segui vs Ralph Terry | Seventh | 5 out |
| Saturday, May 16 |
| » Lost to Yankees (14-10), 10-6 | Yankee Stadium (1-1) | 11-16 | |
| » Starters: Moe Drabowsky vs Stan Williams | Eighth | 6 out |
| Sunday, May 17 |
| » Lost to Yankees (15-10), 11-9 | Yankee Stadium (1-2) | 11-17 | Lost 2 |
| » Starters: John O'Donoghue vs Bill Stafford | Tenth | 6½ out |
| » Lost to Yankees (16-10), 8-0 | Yankee Stadium (1-3) | 11-18 | Lost 3 |
| » Starters: Orlando Pena vs Whitey Ford | Tenth | 6½ out |
| Tuesday, May 19 |
| » Lost to Orioles (18-12), 3-2 | Memorial Stadium (0-1) | 11-19 | Lost 4 |
| » Starters: Moe Drabowsky vs Robin Roberts | Tenth | 7½ out |
| Wednesday, May 20 |
| » Lost to Orioles (19-12), 8-3 | Memorial Stadium (0-2) | 11-20 | Lost 5 |
| » Starters: Diego Segui vs Milt Pappas | Ninth | 8 out |
| Thursday, May 21 |
| » Lost to Orioles (20-12), 7-6 | Memorial Stadium (0-3) | 11-21 | Lost 6 |
| » Starters: John O'Donoghue vs Wally Bunker | Eighth | 8½ out |
| Friday, May 22 |
| » Defeated Red Sox (15-18), 4-3 | Fenway Park (1-0) | 12-21 | |
| » Starters: Orlando Pena vs Earl Wilson | Eighth | 8½ out |
| Saturday, May 23 |
| » Lost to Red Sox (16-18), 5-4 | Fenway Park (1-1) | 12-22 | |
| » Starters: Aurelio Monteagudo vs Bill Monbouquette | Tenth | 9½ out |
| Sunday, May 24 |
| » Lost to Red Sox (17-18), 6-2 | Fenway Park (1-2) | 12-23 | Lost 2 |
| » Starters: Moe Drabowsky vs Jack Lamabe | Tenth | 10½ out |
| » Lost to Red Sox (18-18), 3-1 | Fenway Park (1-3) | 12-24 | Lost 3 |
| » Starters: Diego Segui vs Ed Connolly | Tenth | 10½ out |
| Monday, May 25 |
| » Lost to White Sox (20-10), 7-4 | Municipal Stadium (6-8) | 12-25 | Lost 4 |
| » Starters: Gary Peters vs John O'Donoghue | Tenth | 11½ out |
| Thursday, May 28 |
| » Defeated White Sox (20-11), 4-1 | Municipal Stadium (7-8) | 13-25 | |
| » Starters: Juan Pizarro vs Orlando Pena | Tenth | 10½ out |
| Friday, May 29 |
| » Defeated Yankees (20-15), 4-1 | Municipal Stadium (8-8) | 14-25 | Won 2 |
| » Starters: Jim Bouton vs Diego Segui | Tenth | 10½ out |
| Saturday, May 30 |
| » Lost to Yankees (21-15), 9-1 | Municipal Stadium (8-9) | 14-26 | |
| » Starters: Whitey Ford vs Moe Drabowsky | Tenth | 11½ out |
| Sunday, May 31 |
| » Defeated Yankees (21-16), 4-2 | Municipal Stadium (9-9) | 15-26 | |
| » Starters: Al Downing vs John O'Donoghue | Eighth | 12 out |
| Monday, June 1 |
| » Lost to Orioles (28-15), 8-4 | Municipal Stadium (9-10) | 15-27 | |
| » Starters: Wally Bunker vs Aurelio Monteagudo | Ninth | 12 out |
| Tuesday, June 2 |
| » Lost to Orioles (29-15), 4-0 | Municipal Stadium (9-11) | 15-28 | Lost 2 |
| » Starters: Dave McNally vs Orlando Pena | Tenth | 13½ out |
| Wednesday, June 3 |
| » Lost to Orioles (30-15), 5-1 | Municipal Stadium (9-12) | 15-29 | Lost 3 |
| » Starters: Robin Roberts vs Diego Segui | Tenth | 14½ out |
| Friday, June 5 |
| » Lost to Red Sox (23-24), 14-7 | Municipal Stadium (9-13) | 15-30 | Lost 4 |
| » Starters: Earl Wilson vs Moe Drabowsky | Ninth | 14½ out |
| Saturday, June 6 |
| » Lost to Red Sox (24-24), 8-6 | Municipal Stadium (9-14) | 15-31 | Lost 5 |
| » Starters: Jack Lamabe vs John O'Donoghue | Ninth | 15½ out |
| Sunday, June 7 |
| » Lost to Red Sox (25-24), 9-5 | Municipal Stadium (9-15) | 15-32 | Lost 6 |
| » Starters: Bill Monbouquette vs Orlando Pena | Tenth | 15½ out |
| » Defeated Red Sox (25-25), 8-6 | Municipal Stadium (10-15) | 16-32 | |
| » Starters: Dave Morehead vs Diego Segui | Tenth | 15½ out |
| Monday, June 8 |
| » Defeated Senators (22-32), 5-4 | Robert F. Kennedy Stadium (2-0) | 17-32 | Won 2 |
| » Starters: Moe Drabowsky vs Claude Osteen | Tenth | 15 out |
| Tuesday, June 9 |
| » Lost to Senators (23-32), 8-4 | Robert F. Kennedy Stadium (2-1) | 17-33 | |
| » Starters: John O'Donoghue vs Buster Narum | Tenth | 16½ out |
| » Lost to Senators (24-32), 5-1 | Robert F. Kennedy Stadium (2-2) | 17-34 | Lost 2 |
| » Starters: Dan Pfister vs Tom Cheney | Tenth | 16½ out |
| Wednesday, June 10 |
| » Lost to Senators (25-32), 3-1 | Robert F. Kennedy Stadium (2-3) | 17-35 | Lost 3 |
| » Starters: Ted Bowsfield vs Bennie Daniels | Tenth | 17½ out |
| Friday, June 12 |
| » Lost to Indians (27-24), 3-0 | Cleveland Stadium (0-2) | 17-36 | Lost 4 |
| » Manager: Mel McGaha |
| » Starters: Diego Segui vs Sam McDowell | Tenth | 16½ out |
| Saturday, June 13 |
| » Defeated Indians (27-25), 5-4 | Cleveland Stadium (1-2) | 18-36 | |
| » Starters: Orlando Pena vs Sonny Siebert | Tenth | 15½ out |
| Sunday, June 14 |
| » Defeated Indians (27-26), 6-5 | Cleveland Stadium (2-2) | 19-36 | Won 2 |
| » Starters: Moe Drabowsky vs Dick Donovan | Tenth | 14½ out |
| » Defeated Indians (27-27), 3-2 | Cleveland Stadium (3-2) | 20-36 | Won 3 |
| » Starters: John O'Donoghue vs Tommy John | Tenth | 14½ out |
| Tuesday, June 16 |
| » Defeated Tigers (25-30), 7-4 | Tiger Stadium (1-1) | 21-36 | Won 4 |
| » Starters: Diego Segui vs Hank Aguirre | Tenth | 13 out |
| » Defeated Tigers (25-31), 6-0 | Tiger Stadium (2-1) | 22-36 | Won 5 |
| » Starters: Ted Bowsfield vs Phil Regan | Tenth | 13 out |
| Wednesday, June 17 |
| » Lost to Tigers (26-31), 3-2 | Tiger Stadium (2-2) | 22-37 | |
| » Starters: Orlando Pena vs Dave Wickersham | Tenth | 14 out |
| Thursday, June 18 |
| » Defeated Tigers (26-32), 3-2 | Tiger Stadium (3-2) | 23-37 | |
| » Starters: John O'Donoghue vs Ed Rakow | Tenth | 13 out |
| Friday, June 19 |
| » Defeated Senators (27-38), 5-4 | Municipal Stadium (11-15) | 24-37 | Won 2 |
| » Starters: Bennie Daniels vs Moe Drabowsky | Tenth | 13½ out |
| Saturday, June 20 |
| » Defeated Senators (27-39), 8-2 | Municipal Stadium (12-15) | 25-37 | Won 3 |
| » Starters: Jim Hannan vs Diego Segui | Tenth | 13½ out |
| Sunday, June 21 |
| » Lost to Senators (28-39), 13-2 | Municipal Stadium (12-16) | 25-38 | |
| » Starters: Buster Narum vs Orlando Pena | Tenth | 14 out |
| » Lost to Senators (29-39), 5-2 | Municipal Stadium (12-17) | 25-39 | Lost 2 |
| » Starters: Alan Koch vs Ted Bowsfield | Tenth | 14 out |
| Monday, June 22 |
| Future Athletic Catfish Hunter is born in Jersey City, NJ. |
| Tuesday, June 23 |
| » Defeated Tigers (28-34), 2-1 | Municipal Stadium (13-17) | 26-39 | |
| » Starters: Joe Sparma vs John O'Donoghue | Tenth | 14½ out |
| » Lost to Tigers (29-34), 9-3 | Municipal Stadium (13-18) | 26-40 | |
| » Starters: Mickey Lolich vs Dan Pfister | Tenth | 14½ out |
| Wednesday, June 24 |
| » Lost to Tigers (30-34), 9-5 | Municipal Stadium (13-19) | 26-41 | Lost 2 |
| » Starters: Ed Rakow vs Diego Segui | Tenth | 15½ out |
| Thursday, June 25 |
| » Lost to Angels (33-37), 4-3 | Dodger Stadium (2-3) | 26-42 | Lost 3 |
| » Starters: Ted Bowsfield vs Fred Newman | Tenth | 16½ out |
| Friday, June 26 |
| » Lost to Angels (34-37), 1-0 | Dodger Stadium (2-4) | 26-43 | Lost 4 |
| » Starters: Moe Drabowsky vs Bo Belinsky | Tenth | 18 out |
| » Lost to Angels (35-37), 6-0 | Dodger Stadium (2-5) | 26-44 | Lost 5 |
| » Starters: Orlando Pena vs Bob Meyer | Tenth | 18 out |
| Saturday, June 27 |
| » Defeated Angels (35-38), 2-1 | Dodger Stadium (3-5) | 27-44 | |
| » Starters: John O'Donoghue vs Dean Chance | Tenth | 18 out |
| Sunday, June 28 |
| » Defeated Angels (35-39), 4-0 | Dodger Stadium (4-5) | 28-44 | Won 2 |
| » Starters: Diego Segui vs Barry Latman | Tenth | 18 out |
| Monday, June 29 |
| » Lost to Red Sox (36-37), 4-3 | Fenway Park (1-4) | 28-45 | |
| » Starters: Ted Bowsfield vs Earl Wilson | Tenth | 19 out |
| Tuesday, June 30 |
| » Defeated Red Sox (36-38), 2-1 | Fenway Park (2-4) | 29-45 | |
| » Starters: Moe Drabowsky vs Dave Morehead | Tenth | 18 out |
| Wednesday, July 1 |
| » Defeated Yankees (42-29), 5-4 | Yankee Stadium (2-3) | 30-45 | Won 2 |
| » Starters: John O'Donoghue vs Whitey Ford | Eighth | 18 out |
| Thursday, July 2 |
| » Lost to Yankees (43-29), 4-3 | Yankee Stadium (2-4) | 30-46 | |
| » Starters: Diego Segui vs Rollie Sheldon | Tenth | 18 out |
| Future Athletic Jose Canseco is born in Havana, Cuba. Future Athletic Ozzie Canseco is born in Havana, Cuba. |
| Friday, July 3 |
| » Lost to Orioles (48-27), 4-0 | Memorial Stadium (0-4) | 30-47 | Lost 2 |
| » Starters: Orlando Pena vs Wally Bunker | Tenth | 19 out |
| Saturday, July 4 |
| » Tied Orioles, 6-6 | Memorial Stadium (0-4) | 30-47 | |
| » Starters: Moe Drabowsky vs Robin Roberts | Tenth | 19 out |
| Sunday, July 5 |
| » Defeated Orioles (48-28), 3-1 | Memorial Stadium (1-4) | 31-47 | |
| » Starters: John O'Donoghue vs Steve Barber | Ninth | 18 out |
| Thursday, July 9 |
| » Lost to Twins (44-37), 2-1 | Municipal Stadium (13-20) | 31-48 | |
| » Starters: Jim Kaat vs Jose Santiago | Ninth | 19½ out |
| Friday, July 10 |
| » Lost to Twins (45-37), 9-3 | Municipal Stadium (13-21) | 31-49 | Lost 2 |
| » Starters: Mudcat Grant vs Diego Segui | Ninth | 19½ out |
| Saturday, July 11 |
| » Lost to Twins (46-37), 5-4 | Municipal Stadium (13-22) | 31-50 | Lost 3 |
| » Starters: Camilo Pascual vs Orlando Pena | Ninth | 20½ out |
| Sunday, July 12 |
| » Lost to White Sox (47-32), 3-1 | Municipal Stadium (13-23) | 31-51 | Lost 4 |
| » Starters: John Buzhardt vs John O'Donoghue | Tenth | 21½ out |
| » Lost to White Sox (48-32), 11-4 | Municipal Stadium (13-24) | 31-52 | Lost 5 |
| » Starters: Eddie Fisher vs Moe Drabowsky | Tenth | 21½ out |
| Monday, July 13 |
| » Lost to White Sox (49-32), 8-6 | Municipal Stadium (13-25) | 31-53 | Lost 6 |
| » Starters: Gary Peters vs Jose Santiago | Ninth | 21 out |
| » Defeated White Sox (49-33), 8-7 | Municipal Stadium (14-25) | 32-53 | |
| » Starters: Ray Herbert vs Dan Pfister | Ninth | 21 out |
| Tuesday, July 14 |
| » Lost to Indians (36-46), 9-7 | Municipal Stadium (14-26) | 32-54 | |
| » Starters: Sam McDowell vs Diego Segui | Tenth | 21 out |
| Wednesday, July 15 |
| » Defeated Indians (36-47), 5-3 | Municipal Stadium (15-26) | 33-54 | |
| » Starters: Jack Kralick vs Orlando Pena | Ninth | 20 out |
| » Defeated Indians (36-48), 3-2 | Municipal Stadium (16-26) | 34-54 | Won 2 |
| » Starters: Lee Stange vs Ted Bowsfield | Ninth | 20 out |
| Thursday, July 16 |
| » Lost to Indians (37-48), 12-9 | Municipal Stadium (16-27) | 34-55 | |
| » Starters: Tommy John vs John O'Donoghue | Ninth | 20½ out |
| Friday, July 17 |
| » Lost to White Sox (52-34), 6-1 | Comiskey Park I (0-3) | 34-56 | Lost 2 |
| » Starters: Moe Drabowsky vs Gary Peters | Ninth | 21½ out |
| Sunday, July 19 |
| » Lost to White Sox (53-34), 3-2 | Comiskey Park I (0-4) | 34-57 | Lost 3 |
| » Starters: Diego Segui vs Juan Pizarro | Tenth | 23 out |
| » Lost to White Sox (54-34), 4-3 | Comiskey Park I (0-5) | 34-58 | Lost 4 |
| » Starters: John O'Donoghue vs Ray Herbert | Tenth | 23 out |
| Tuesday, July 21 |
| » Defeated Twins (47-46), 5-4 | Metropolitan Stadium (2-2) | 35-58 | |
| » Starters: Jose Santiago vs Camilo Pascual | Ninth | 21½ out |
| Wednesday, July 22 |
| » Defeated Twins (47-47), 6-4 | Metropolitan Stadium (3-2) | 36-58 | Won 2 |
| » Starters: Orlando Pena vs Dick Stigman | Eighth | 21½ out |
| Thursday, July 23 |
| » Defeated Twins (47-48), 4-3 | Metropolitan Stadium (4-2) | 37-58 | Won 3 |
| » Starters: Diego Segui vs Jim Kaat | Eighth | 20½ out |
| Friday, July 24 |
| » Defeated Angels (50-50), 1-0 | Municipal Stadium (17-27) | 38-58 | Won 4 |
| » Starters: Don Lee vs John O'Donoghue | Ninth | 21 out |
| Saturday, July 25 |
| » Lost to Angels (51-50), 18-2 | Municipal Stadium (17-28) | 38-59 | |
| » Starters: Bo Belinsky vs Moe Drabowsky | Ninth | 22 out |
| Sunday, July 26 |
| » Lost to Angels (52-50), 3-0 | Municipal Stadium (17-29) | 38-60 | Lost 2 |
| » Starters: Aubrey Gatewood vs Jose Santiago | Ninth | 23 out |
| » Lost to Angels (53-50), 4-3 | Municipal Stadium (17-30) | 38-61 | Lost 3 |
| » Starters: Dan Osinski vs Ted Bowsfield | Ninth | 23 out |
| Monday, July 27 |
| » Major-league debuts: Dave Eilers (Braves) |
| Tuesday, July 28 |
| » Defeated Red Sox (50-52), 2-1 | Municipal Stadium (18-30) | 39-61 | |
| » Starters: Dave Morehead vs Orlando Pena | Ninth | 22½ out |
| Wednesday, July 29 |
| » Lost to Red Sox (51-52), 3-2 | Municipal Stadium (18-31) | 39-62 | |
| » Starters: Bob Heffner vs Diego Segui | Ninth | 23½ out |
| Friday, July 31 |
| » Lost to Orioles (63-39), 6-1 | Municipal Stadium (18-32) | 39-63 | Lost 2 |
| » Starters: Wally Bunker vs John O'Donoghue | Ninth | 23 out |
| » Defeated Orioles (63-40), 7-6 | Municipal Stadium (19-32) | 40-63 | |
| » Starters: Dave McNally vs Ted Bowsfield | Ninth | 23 out |
| Saturday, August 1 |
| » Lost to Orioles (64-40), 5-2 | Municipal Stadium (19-33) | 40-64 | |
| » Starters: Frank Bertaina vs Orlando Pena | Ninth | 24 out |
| » Major-league debuts: Frank Bertaina (Orioles) |
| Sunday, August 2 |
| » Lost to Orioles (65-40), 8-7 | Municipal Stadium (19-34) | 40-65 | Lost 2 |
| » Starters: Robin Roberts vs Diego Segui | Ninth | 25 out |
| Tuesday, August 4 |
| » Defeated Yankees (63-39), 5-1 | Municipal Stadium (20-34) | 41-65 | |
| » Starters: Whitey Ford vs John O'Donoghue | Ninth | 24 out |
| Wednesday, August 5 |
| » Defeated Yankees (63-40), 10-1 | Municipal Stadium (21-34) | 42-65 | Won 2 |
| » Starters: Al Downing vs Orlando Pena | Ninth | 23 out |
| Thursday, August 6 |
| » Lost to Yankees (64-40), 5-3 | Municipal Stadium (21-35) | 42-66 | |
| » Starters: Ralph Terry vs Diego Segui | Ninth | 24 out |
| Friday, August 7 |
| » Lost to Tigers (55-57), 5-2 | Tiger Stadium (3-3) | 42-67 | Lost 2 |
| » Starters: Ted Bowsfield vs Phil Regan | Ninth | 25 out |
| Saturday, August 8 |
| » Lost to Tigers (56-57), 4-3 | Tiger Stadium (3-4) | 42-68 | Lost 3 |
| » Starters: John O'Donoghue vs Dave Wickersham | Eighth | 26 out |
| Sunday, August 9 |
| » Lost to Tigers (57-57), 4-2 | Tiger Stadium (3-5) | 42-69 | Lost 4 |
| » Starters: Orlando Pena vs Joe Sparma | Ninth | 27 out |
| » Lost to Tigers (58-57), 5-2 | Tiger Stadium (3-6) | 42-70 | Lost 5 |
| » Starters: Moe Drabowsky vs Denny McLain | Ninth | 27 out |
| Tuesday, August 11 |
| » Lost to Senators (45-72), 5-2 | Municipal Stadium (21-36) | 42-71 | Lost 6 |
| » Starters: Claude Osteen vs Diego Segui | Tenth | 28 out |
| Wednesday, August 12 |
| » Lost to Senators (46-72), 4-3 | Municipal Stadium (21-37) | 42-72 | Lost 7 |
| » Starters: Buster Narum vs Jose Santiago | Tenth | 29 out |
| Friday, August 14 |
| » Defeated Tigers (59-60), 5-4 | Municipal Stadium (22-37) | 43-72 | |
| » Starters: Phil Regan vs Orlando Pena | Tenth | 29½ out |
| Saturday, August 15 |
| » Lost to Tigers (60-60), 5-1 | Municipal Stadium (22-38) | 43-73 | |
| » Starters: Denny McLain vs Diego Segui | Tenth | 29½ out |
| Sunday, August 16 |
| » Lost to Tigers (61-60), 11-5 | Municipal Stadium (22-39) | 43-74 | Lost 2 |
| » Starters: Dave Wickersham vs John O'Donoghue | Ninth | 29½ out |
| Tuesday, August 18 |
| » Defeated Indians (54-65), 13-9 | Cleveland Stadium (4-2) | 44-74 | |
| » Starters: Jose Santiago vs Jack Kralick | Ninth | 30 out |
| » Lost to Indians (55-65), 5-1 | Cleveland Stadium (4-3) | 44-75 | |
| » Starters: Orlando Pena vs Luis Tiant | Ninth | 30 out |
| Wednesday, August 19 |
| » Lost to Indians (56-65), 6-4 | Cleveland Stadium (4-4) | 44-76 | Lost 2 |
| » Starters: Diego Segui vs Sam McDowell | Tenth | 30 out |
| Thursday, August 20 |
| » Defeated Indians (56-66), 7-4 | Cleveland Stadium (5-4) | 45-76 | |
| » Starters: Bob Meyer vs Lee Stange | Eighth | 29½ out |
| Friday, August 21 |
| » Defeated Senators (49-76), 3-2 | Robert F. Kennedy Stadium (3-3) | 46-76 | Won 2 |
| » Starters: John O'Donoghue vs Claude Osteen | Tenth | 29 out |
| Future Athletic Shawn Hillegas is born in Dos Palos, CA. |
| Saturday, August 22 |
| » Defeated Senators (49-77), 6-2 | Robert F. Kennedy Stadium (4-3) | 47-76 | Won 3 |
| » Starters: Orlando Pena vs Buster Narum | Tenth | 29 out |
| Sunday, August 23 |
| » Defeated Senators (49-78), 3-1 | Robert F. Kennedy Stadium (5-3) | 48-76 | Won 4 |
| » Starters: Diego Segui vs Bennie Daniels | Tenth | 29 out |
| » Lost to Senators (50-78), 8-5 | Robert F. Kennedy Stadium (5-4) | 48-77 | |
| » Starters: Jose Santiago vs Frank Kreutzer | Tenth | 29 out |
| Tuesday, August 25 |
| » Lost to Angels (64-66), 5-3 | Municipal Stadium (22-40) | 48-78 | Lost 2 |
| » Starters: Dean Chance vs Bob Meyer | Tenth | 29 out |
| Wednesday, August 26 |
| » Lost to Angels (65-66), 5-2 | Municipal Stadium (22-41) | 48-79 | Lost 3 |
| » Starters: Aubrey Gatewood vs John O'Donoghue | Tenth | 29 out |
| Thursday, August 27 |
| » Lost to Angels (66-66), 7-1 | Municipal Stadium (22-42) | 48-80 | Lost 4 |
| » Starters: George Brunet vs Diego Segui | Tenth | 29½ out |
| Friday, August 28 |
| » Lost to Indians (63-66), 4-1 | Municipal Stadium (22-43) | 48-81 | Lost 5 |
| » Starters: Sonny Siebert vs Orlando Pena | Tenth | 30 out |
| Saturday, August 29 |
| » Lost to Indians (64-66), 4-3 | Municipal Stadium (22-44) | 48-82 | Lost 6 |
| » Starters: Luis Tiant vs Moe Drabowsky | Ninth | 31 out |
| Sunday, August 30 |
| » Defeated Indians (64-67), 9-3 | Municipal Stadium (23-44) | 49-82 | |
| » Starters: Jack Kralick vs John O'Donoghue | Tenth | 30½ out |
| » Lost to Indians (65-67), 6-5 | Municipal Stadium (23-45) | 49-83 | |
| » Starters: Dick Donovan vs Bob Meyer | Tenth | 30½ out |
| Tuesday, September 1 |
| » Lost to Red Sox (60-74), 3-2 | Municipal Stadium (23-46) | 49-84 | Lost 2 |
| » Starters: Jack Lamabe vs Diego Segui | Tenth | 30½ out |
| Wednesday, September 2 |
| » Defeated Red Sox (60-75), 9-5 | Municipal Stadium (24-46) | 50-84 | |
| » Starters: Bill Monbouquette vs Orlando Pena | Ninth | 30½ out |
| Thursday, September 3 |
| » Lost to Red Sox (61-75), 7-5 | Municipal Stadium (24-47) | 50-85 | |
| » Starters: Earl Wilson vs Moe Drabowsky | Tenth | 31½ out |
| Friday, September 4 |
| » Lost to Yankees (77-56), 9-7 | Municipal Stadium (24-48) | 50-86 | Lost 2 |
| » Starters: Whitey Ford vs John O'Donoghue | Tenth | 31½ out |
| Saturday, September 5 |
| » Lost to Yankees (78-56), 9-7 | Municipal Stadium (24-49) | 50-87 | Lost 3 |
| » Starters: Al Downing vs Blue Moon Odom | Tenth | 32½ out |
| Sunday, September 6 |
| » Lost to Yankees (79-56), 3-2 | Municipal Stadium (24-50) | 50-88 | Lost 4 |
| » Starters: Rollie Sheldon vs Diego Segui | Tenth | 33 out |
| Monday, September 7 |
| » Lost to Orioles (83-55), 6-1 | Municipal Stadium (24-51) | 50-89 | Lost 5 |
| » Starters: Wally Bunker vs Orlando Pena | Tenth | 32½ out |
| » Defeated Orioles (83-56), 6-1 | Municipal Stadium (25-51) | 51-89 | |
| » Starters: Dave McNally vs Bob Meyer | Tenth | 32½ out |
| Friday, September 11 |
| » Lost to Orioles (86-57), 5-2 | Memorial Stadium (1-5) | 51-90 | |
| » Starters: John O'Donoghue vs Wally Bunker | Tenth | 33 out |
| » Defeated Orioles (86-58), 8-0 | Memorial Stadium (2-5) | 52-90 | |
| » Starters: Blue Moon Odom vs Dave Vineyard | Tenth | 33 out |
| Saturday, September 12 |
| » Lost to Orioles (87-58), 1-0 | Memorial Stadium (2-6) | 52-91 | |
| » Starters: Bob Meyer vs Frank Bertaina | Tenth | 34 out |
| Sunday, September 13 |
| » Defeated Orioles (87-59), 7-5 | Memorial Stadium (3-6) | 53-91 | |
| » Starters: Diego Segui vs Steve Barber | Tenth | 33 out |
| Monday, September 14 |
| » Defeated Red Sox (64-83), 7-6 | Fenway Park (3-4) | 54-91 | Won 2 |
| » Starters: Orlando Pena vs Dave Gray | Tenth | 33 out |
| Tuesday, September 15 |
| » Lost to Red Sox (65-83), 8-0 | Fenway Park (3-5) | 54-92 | |
| » Starters: John O'Donoghue vs Ed Connolly | Tenth | 33 out |
| Wednesday, September 16 |
| » Lost to Red Sox (66-83), 10-1 | Fenway Park (3-6) | 54-93 | Lost 2 |
| » Starters: Blue Moon Odom vs Bill Monbouquette | Ninth | 33 out |
| Friday, September 18 |
| » Lost to Yankees (87-59), 6-0 | Yankee Stadium (2-5) | 54-94 | Lost 3 |
| » Starters: Bob Meyer vs Whitey Ford | Tenth | 34 out |
| Saturday, September 19 |
| » Lost to Yankees (88-59), 8-3 | Yankee Stadium (2-6) | 54-95 | Lost 4 |
| » Starters: Diego Segui vs Al Downing | Tenth | 35 out |
| Sunday, September 20 |
| » Lost to Yankees (89-59), 4-0 | Yankee Stadium (2-7) | 54-96 | Lost 5 |
| » Starters: John O'Donoghue vs Jim Bouton | Tenth | 36 out |
| Tuesday, September 22 |
| » Defeated Twins (75-77), 10-9 | Municipal Stadium (26-51) | 55-96 | |
| » Starters: Camilo Pascual vs Blue Moon Odom | Tenth | 36½ out |
| Wednesday, September 23 |
| » Lost to Twins (76-77), 2-1 | Municipal Stadium (26-52) | 55-97 | |
| » Starters: Dave Boswell vs Lew Krausse | Eighth | 38 out |
| Friday, September 25 |
| » Lost to White Sox (91-64), 11-3 | Municipal Stadium (26-53) | 55-98 | Lost 2 |
| » Starters: Juan Pizarro vs John O'Donoghue | Eighth | 39 out |
| Saturday, September 26 |
| » Lost to White Sox (92-64), 5-2 | Municipal Stadium (26-54) | 55-99 | Lost 3 |
| » Starters: Gary Peters vs Bob Meyer | Eighth | 40 out |
| Sunday, September 27 |
| » Lost to White Sox (93-64), 5-3 | Municipal Stadium (26-55) | 55-100 | Lost 4 |
| » Starters: Joe Horlen vs Blue Moon Odom | Ninth | 40 out |
| Tuesday, September 29 |
| » Defeated Twins (77-80), 7-6 | Metropolitan Stadium (5-2) | 56-100 | |
| » Starters: Lew Krausse vs Dave Boswell | Tenth | 39½ out |
| Wednesday, September 30 |
| » Lost to Twins (78-80), 6-1 | Metropolitan Stadium (5-3) | 56-101 | |
| » Starters: Diego Segui vs Mudcat Grant | Ninth | 41 out |
| Future Athletic Doug Jennings is born in Atlanta, GA. |
| Thursday, October 1 |
| » Defeated Twins (78-81), 5-4 | Metropolitan Stadium (6-3) | 57-101 | |
| » Starters: Orlando Pena vs Camilo Pascual | Ninth | 39½ out |
| Friday, October 2 |
| » Lost to White Sox (95-64), 3-2 | Comiskey Park I (0-6) | 57-102 | |
| » Starters: Jose Santiago vs Juan Pizarro | Ninth | 41 out |
| » Lost to White Sox (96-64), 5-4 | Comiskey Park I (0-7) | 57-103 | Lost 2 |
| » Starters: Lew Krausse vs Gary Peters | Ninth | 41 out |
| Saturday, October 3 |
| » Lost to White Sox (97-64), 7-0 | Comiskey Park I (0-8) | 57-104 | Lost 3 |
| » Starters: John O'Donoghue vs Joe Horlen | Tenth | 42 out |
| Sunday, October 4 |
| » Lost to White Sox (98-64), 6-0 | Comiskey Park I (0-9) | 57-105 | Lost 4 |
| » Starters: Diego Segui vs Bruce Howard | Ninth | 42 out |
| Friday, October 9 |
| Former Athletic Al Wingo dies in Detroit, MI at the age of 67. |
