| Friday, January 3 |
| Future Astro Luis Rivera is born in Cidra, P.R. |
| Tuesday, January 7 |
| Future Astro Dave Meads is born in Montclair, NJ. |
| Thursday, January 9 |
| Future Astro Stan Javier is born in San Francisco De Macoris, D.R. |
| Friday, January 17 |
| Future Astro Jeff Tabaka is born in Barberton, OH. |
| Thursday, April 2 |
| Future Astro Pete Incaviglia is born in Pebble Beach, CA. |
| Wednesday, April 8 |
| Former Astro Jim Umbricht dies in Houston, TX at the age of 34. |
| Sunday, April 12 |
| Future Astro Jerry Goff is born in San Rafael, CA. |
| Monday, April 13 |
| » Defeated Reds (0-1), 6-3 | Crosley Field (1-0) | 1-0 | |
| » Starters: Ken Johnson vs Jim Maloney | First | -- |
| » Major-league debuts: Mel Queen and Chico Ruiz (Reds) |
| Thursday, April 16 |
| » Lost to Braves (1-2), 6-5 | Colt Stadium (0-1) | 1-1 | |
| » Starters: Denny Lemaster vs Jim Owens | Third | 1 out |
| Friday, April 17 |
| » Lost to Braves (2-2), 5-2 | Colt Stadium (0-2) | 1-2 | Lost 2 |
| » Starters: Hank Fischer vs Hal Brown | Fifth | 2 out |
| Saturday, April 18 |
| » Defeated Braves (2-3), 4-2 | Colt Stadium (1-2) | 2-2 | |
| » Starters: Tony Cloninger vs Ken Johnson | Third | 1 out |
| Sunday, April 19 |
| » Lost to Cardinals (4-2), 6-1 | Colt Stadium (1-3) | 2-3 | |
| » Starters: Bob Gibson vs Don Nottebart | Fifth | 2 out |
| Monday, April 20 |
| » Defeated Cardinals (4-3), 7-1 | Colt Stadium (2-3) | 3-3 | |
| » Starters: Ray Sadecki vs Turk Farrell | Fifth | 1½ out |
| Future Astro Jimmy Jones is born in Dallas, TX. |
| Tuesday, April 21 |
| » Lost to Reds (4-3), 10-5 | Colt Stadium (2-4) | 3-4 | |
| » Starters: Jim O'Toole vs Jim Owens | Fifth | 2 out |
| » Major-league debuts: Walt Williams (Astros) Bobby Klaus (Reds) |
| Wednesday, April 22 |
| » Defeated Reds (4-4), 2-0 | Colt Stadium (3-4) | 4-4 | |
| » Starters: Joey Jay vs Bob Bruce | Fifth | 1½ out |
| Thursday, April 23 |
| » Lost to Reds (5-4), 1-0 | Colt Stadium (3-5) | 4-5 | |
| » Starters: Joe Nuxhall vs Ken Johnson | Sixth | 2½ out |
| Friday, April 24 |
| » Lost to Cardinals (6-4), 3-2 | Sportsman's Park III (0-1) | 4-6 | Lost 2 |
| » Starters: Don Nottebart vs Bob Gibson | Seventh | 3½ out |
| Saturday, April 25 |
| » Defeated Cardinals (6-5), 4-2 | Sportsman's Park III (1-1) | 5-6 | |
| » Starters: Turk Farrell vs Roger Craig | Sixth | 2½ out |
| Sunday, April 26 |
| » Defeated Cardinals (6-6), 6-4 | Sportsman's Park III (2-1) | 6-6 | Won 2 |
| » Starters: Jim Owens vs Curt Simmons | Fifth | 2½ out |
| Monday, April 27 |
| » Lost to Dodgers (4-9), 6-0 | Colt Stadium (3-6) | 6-7 | |
| » Starters: Don Drysdale vs Hal Brown | Sixth | 3 out |
| Tuesday, April 28 |
| » Lost to Dodgers (5-9), 3-1 | Colt Stadium (3-7) | 6-8 | Lost 2 |
| » Starters: Joe Moeller vs Ken Johnson | Sixth | 4 out |
| Wednesday, April 29 |
| » Lost to Dodgers (6-9), 7-2 | Colt Stadium (3-8) | 6-9 | Lost 3 |
| » Starters: Nick Willhite vs Don Nottebart | Seventh | 4½ out |
| Thursday, April 30 |
| » Defeated Dodgers (6-10), 7-3 | Colt Stadium (4-8) | 7-9 | |
| » Starters: Phil Ortega vs Turk Farrell | Seventh | 4½ out |
| Friday, May 1 |
| » Lost to Cubs (5-7), 11-3 | Colt Stadium (4-9) | 7-10 | |
| » Starters: Larry Jackson vs Bob Bruce | Seventh | 5½ out |
| Saturday, May 2 |
| » Lost to Cubs (6-7), 9-0 | Colt Stadium (4-10) | 7-11 | Lost 2 |
| » Starters: Bob Buhl vs Jim Owens | Eighth | 5½ out |
| Sunday, May 3 |
| » Defeated Cubs (6-8), 5-3 | Colt Stadium (5-10) | 8-11 | |
| » Starters: Fred Norman vs Hal Brown | Sixth | 4½ out |
| Monday, May 4 |
| » Lost to Giants (11-4), 3-2 | Candlestick Park (0-1) | 8-12 | |
| » Starters: Ken Johnson vs Bobby Bolin | Eighth | 5½ out |
| Tuesday, May 5 |
| » Lost to Giants (12-4), 2-1 | Candlestick Park (0-2) | 8-13 | Lost 2 |
| » Starters: Don Nottebart vs Jack Sanford | Ninth | 6½ out |
| Wednesday, May 6 |
| » Lost to Dodgers (9-12), 5-2 | Dodger Stadium (0-1) | 8-14 | Lost 3 |
| » Starters: Turk Farrell vs Don Drysdale | Eighth | 6½ out |
| Thursday, May 7 |
| » Defeated Dodgers (9-13), 2-1 | Dodger Stadium (1-1) | 9-14 | |
| » Starters: Bob Bruce vs Joe Moeller | Ninth | 6½ out |
| Saturday, May 9 |
| » Lost to Cubs (8-10), 9-1 | Wrigley Field (0-1) | 9-15 | |
| » Starters: Ken Johnson vs Dick Ellsworth | Eighth | 8 out |
| Sunday, May 10 |
| » Lost to Cubs (9-10), 4-3 | Wrigley Field (0-2) | 9-16 | Lost 2 |
| » Starters: Don Nottebart vs Larry Jackson | Ninth | 7½ out |
| » Defeated Cubs (9-11), 4-1 | Wrigley Field (1-2) | 10-16 | |
| » Starters: Jim Owens vs Glen Hobbie | Ninth | 7½ out |
| Monday, May 11 |
| » Defeated Giants (15-7), 4-1 | Colt Stadium (6-10) | 11-16 | Won 2 |
| » Starters: Billy O'Dell vs Turk Farrell | Seventh | 6½ out |
| Tuesday, May 12 |
| » Lost to Giants (16-7), 6-0 | Colt Stadium (6-11) | 11-17 | |
| » Starters: Juan Marichal vs Hal Brown | Eighth | 7½ out |
| Wednesday, May 13 |
| » Defeated Giants (16-8), 2-1 | Colt Stadium (7-11) | 12-17 | |
| » Starters: Bob Hendley vs Ken Johnson | Eighth | 6½ out |
| Thursday, May 14 |
| » Defeated Giants (16-9), 4-3 | Colt Stadium (8-11) | 13-17 | Won 2 |
| » Starters: Jack Sanford vs Bob Bruce | Eighth | 5½ out |
| Friday, May 15 |
| » Lost to Phillies (16-9), 4-0 | Colt Stadium (8-12) | 13-18 | |
| » Starters: Dennis Bennett vs Don Nottebart | Seventh | 6 out |
| Saturday, May 16 |
| » Defeated Phillies (16-10), 4-3 | Colt Stadium (9-12) | 14-18 | |
| » Starters: Ray Culp vs Turk Farrell | Sixth | 5½ out |
| Sunday, May 17 |
| » Lost to Phillies (17-10), 2-0 | Colt Stadium (9-13) | 14-19 | |
| » Starters: Chris Short vs Jim Owens | Seventh | 7 out |
| Monday, May 18 |
| » Lost to Phillies (18-10), 4-0 | Colt Stadium (9-14) | 14-20 | Lost 2 |
| » Starters: Jim Bunning vs Ken Johnson | Eighth | 7 out |
| Tuesday, May 19 |
| » Defeated Pirates (17-15), 3-1 | Colt Stadium (10-14) | 15-20 | |
| » Starters: Bob Friend vs Bob Bruce | Eighth | 7 out |
| Wednesday, May 20 |
| » Lost to Pirates (18-15), 4-3 | Colt Stadium (10-15) | 15-21 | |
| » Starters: Bob Veale vs Don Nottebart | Seventh | 7 out |
| Thursday, May 21 |
| » Defeated Pirates (18-16), 3-1 | Colt Stadium (11-15) | 16-21 | |
| » Starters: Vern Law vs Turk Farrell | Eighth | 7 out |
| Friday, May 22 |
| » Lost to Mets (11-25), 2-1 | Colt Stadium (11-16) | 16-22 | |
| » Starters: Al Jackson vs Hal Brown | Eighth | 8 out |
| Saturday, May 23 |
| » Defeated Mets (11-26), 8-4 | Colt Stadium (12-16) | 17-22 | |
| » Starters: Galen Cisco vs Jim Owens | Seventh | 6½ out |
| » Defeated Mets (11-27), 4-0 | Colt Stadium (13-16) | 18-22 | Won 2 |
| » Starters: Craig Anderson vs Ken Johnson | Seventh | 6½ out |
| Sunday, May 24 |
| » Defeated Mets (11-28), 5-0 | Colt Stadium (14-16) | 19-22 | Won 3 |
| » Starters: Tracy Stallard vs Bob Bruce | Seventh | 5½ out |
| Tuesday, May 26 |
| » Defeated Braves (21-17), 4-2 | County Stadium (1-0) | 20-22 | Won 4 |
| » Starters: Turk Farrell vs Tony Cloninger | Sixth | 4½ out |
| Wednesday, May 27 |
| » Lost to Braves (22-17), 2-0 | County Stadium (1-1) | 20-23 | |
| » Starters: Hal Brown vs Hank Fischer | Sixth | 5½ out |
| Thursday, May 28 |
| » Defeated Braves (22-18), 4-2 | County Stadium (2-1) | 21-23 | |
| » Starters: Ken Johnson vs Warren Spahn | Seventh | 5½ out |
| Friday, May 29 |
| » Lost to Phillies (23-15), 7-6 | Shibe Park (0-1) | 21-24 | |
| » Starters: Bob Bruce vs Jim Bunning | Sixth | 5½ out |
| Saturday, May 30 |
| » Lost to Phillies (24-15), 5-1 | Shibe Park (0-2) | 21-25 | Lost 2 |
| » Starters: Don Nottebart vs Chris Short | Seventh | 6½ out |
| Sunday, May 31 |
| » Lost to Phillies (25-15), 4-1 | Shibe Park (0-3) | 21-26 | Lost 3 |
| » Starters: Jim Owens vs Art Mahaffey | Eighth | 7½ out |
| Tuesday, June 2 |
| » Lost to Mets (15-32), 7-4 | Shea Stadium (0-1) | 21-27 | Lost 4 |
| » Starters: Ken Johnson vs Tracy Stallard | Ninth | 8½ out |
| Thursday, June 4 |
| » Defeated Mets (15-33), 7-3 | Shea Stadium (1-1) | 22-27 | |
| » Starters: Turk Farrell vs Al Jackson | Ninth | 8 out |
| Friday, June 5 |
| » Lost to Pirates (26-22), 4-3 | Forbes Field (0-1) | 22-28 | |
| » Starters: Don Nottebart vs Bob Friend | Ninth | 8 out |
| Sunday, June 7 |
| » Defeated Pirates (26-23), 6-3 | Forbes Field (1-1) | 23-28 | |
| » Starters: Ken Johnson vs Bob Veale | Ninth | 8½ out |
| » Lost to Pirates (27-23), 6-1 | Forbes Field (1-2) | 23-29 | |
| » Starters: Bob Bruce vs Vern Law | Ninth | 8½ out |
| Monday, June 8 |
| » Lost to Braves (26-25), 5-3 | Colt Stadium (14-17) | 23-30 | Lost 2 |
| » Starters: Tony Cloninger vs Hal Brown | Eighth | 9 out |
| Tuesday, June 9 |
| » Defeated Braves (26-26), 6-5 | Colt Stadium (15-17) | 24-30 | |
| » Starters: Hank Fischer vs Turk Farrell | Ninth | 7½ out |
| » Defeated Braves (26-27), 4-1 | Colt Stadium (16-17) | 25-30 | Won 2 |
| » Starters: Bob Sadowski vs Don Nottebart | Ninth | 7½ out |
| Thursday, June 11 |
| » Defeated Reds (28-24), 5-3 | Colt Stadium (17-17) | 26-30 | Won 3 |
| » Starters: John Tsitouris vs Bob Bruce | Ninth | 6½ out |
| Friday, June 12 |
| » Lost to Reds (29-24), 3-0 | Colt Stadium (17-18) | 26-31 | |
| » Starters: Joe Nuxhall vs Ken Johnson | Ninth | 6½ out |
| Saturday, June 13 |
| » Lost to Reds (30-24), 6-1 | Colt Stadium (17-19) | 26-32 | Lost 2 |
| » Starters: Jim Maloney vs Hal Brown | Eighth | 7½ out |
| Sunday, June 14 |
| » Defeated Cardinals (28-30), 4-1 | Colt Stadium (18-19) | 27-32 | |
| » Starters: Bob Gibson vs Turk Farrell | Eighth | 8 out |
| Monday, June 15 |
| » Defeated Cardinals (28-31), 9-3 | Colt Stadium (19-19) | 28-32 | Won 2 |
| » Starters: Glen Hobbie vs Don Nottebart | Ninth | 7½ out |
| Tuesday, June 16 |
| » Lost to Cardinals (29-31), 7-1 | Colt Stadium (19-20) | 28-33 | |
| » Starters: Curt Simmons vs Bob Bruce | Ninth | 8½ out |
| Wednesday, June 17 |
| » Lost to Cardinals (30-31), 2-1 | Colt Stadium (19-21) | 28-34 | Lost 2 |
| » Starters: Ray Washburn vs Ken Johnson | Seventh | 8½ out |
| Friday, June 19 |
| » Defeated Braves (30-31), 9-7 | County Stadium (3-1) | 29-34 | |
| » Starters: Turk Farrell vs Dan Schneider | Seventh | 9½ out |
| Saturday, June 20 |
| » Defeated Braves (30-32), 3-2 | County Stadium (4-1) | 30-34 | Won 2 |
| » Starters: Don Nottebart vs Tony Cloninger | Seventh | 8½ out |
| Sunday, June 21 |
| » Defeated Braves (30-33), 5-2 | County Stadium (5-1) | 31-34 | Won 3 |
| » Starters: Bob Bruce vs Warren Spahn | Seventh | 8½ out |
| » Defeated Braves (30-34), 5-4 | County Stadium (6-1) | 32-34 | Won 4 |
| » Starters: Ken Johnson vs Denny Lemaster | Seventh | 8½ out |
| Tuesday, June 23 |
| » Lost to Cardinals (33-33), 5-4 | Sportsman's Park III (2-2) | 32-35 | |
| » Starters: Turk Farrell vs Ray Washburn | Eighth | 9 out |
| Wednesday, June 24 |
| » Defeated Cardinals (33-34), 7-5 | Sportsman's Park III (3-2) | 33-35 | |
| » Starters: Don Nottebart vs Ray Sadecki | Seventh | 9 out |
| Thursday, June 25 |
| » Lost to Cardinals (34-34), 4-2 | Sportsman's Park III (3-3) | 33-36 | |
| » Starters: Bob Bruce vs Roger Craig | Eighth | 9½ out |
| Friday, June 26 |
| » Lost to Cubs (32-32), 7-6 | Wrigley Field (1-3) | 33-37 | Lost 2 |
| » Starters: Ken Johnson vs Larry Jackson | Eighth | 10½ out |
| Saturday, June 27 |
| » Lost to Cubs (33-32), 2-1 | Wrigley Field (1-4) | 33-38 | Lost 3 |
| » Starters: Turk Farrell vs Dick Ellsworth | Eighth | 10½ out |
| Sunday, June 28 |
| » Lost to Cubs (34-32), 10-2 | Wrigley Field (1-5) | 33-39 | Lost 4 |
| » Starters: Hal Brown vs Bob Buhl | Eighth | 11 out |
| » Defeated Cubs (34-33), 4-1 | Wrigley Field (2-5) | 34-39 | |
| » Starters: Don Nottebart vs Ernie Broglio | Eighth | 11 out |
| » Major-league debuts: Vic Roznovsky (Cubs) |
| Monday, June 29 |
| » Defeated Phillies (42-27), 6-1 | Colt Stadium (20-21) | 35-39 | Won 2 |
| » Starters: Art Mahaffey vs Bob Bruce | Eighth | 10 out |
| Tuesday, June 30 |
| » Lost to Phillies (43-27), 8-1 | Colt Stadium (20-22) | 35-40 | |
| » Starters: Jim Bunning vs Ken Johnson | Ninth | 11 out |
| Wednesday, July 1 |
| » Lost to Mets (23-54), 8-6 | Colt Stadium (20-23) | 35-41 | Lost 2 |
| » Starters: Tracy Stallard vs Turk Farrell | Ninth | 12 out |
| Thursday, July 2 |
| » Defeated Mets (23-55), 7-1 | Colt Stadium (21-23) | 36-41 | |
| » Starters: Darrell Sutherland vs Ken Johnson | Ninth | 12 out |
| Friday, July 3 |
| » Lost to Pirates (39-34), 2-1 | Colt Stadium (21-24) | 36-42 | |
| » Starters: Vern Law vs Hal Brown | Ninth | 12 out |
| Saturday, July 4 |
| » Defeated Pirates (39-35), 3-1 | Colt Stadium (22-24) | 37-42 | |
| » Starters: Bob Friend vs Bob Bruce | Ninth | 11½ out |
| Sunday, July 5 |
| » Lost to Pirates (40-35), 7-1 | Colt Stadium (22-25) | 37-43 | |
| » Starters: Joe Gibbon vs Turk Farrell | Ninth | 12½ out |
| Thursday, July 9 |
| » Defeated Dodgers (38-40), 6-5 | Colt Stadium (23-25) | 38-43 | |
| » Starters: Don Drysdale vs Ken Johnson | Ninth | 12½ out |
| Friday, July 10 |
| » Lost to Dodgers (39-40), 4-3 | Colt Stadium (23-26) | 38-44 | |
| » Starters: Sandy Koufax vs Turk Farrell | Ninth | 12½ out |
| Saturday, July 11 |
| » Lost to Dodgers (40-40), 11-9 | Colt Stadium (23-27) | 38-45 | Lost 2 |
| » Starters: Larry Miller vs Bob Bruce | Ninth | 12½ out |
| Sunday, July 12 |
| » Defeated Giants (51-33), 5-4 | Colt Stadium (24-27) | 39-45 | |
| » Starters: Ron Herbel vs Don Nottebart | Eighth | 12 out |
| Monday, July 13 |
| » Lost to Giants (52-33), 5-3 | Colt Stadium (24-28) | 39-46 | |
| » Starters: Bob Hendley vs Hal Brown | Ninth | 13 out |
| Tuesday, July 14 |
| » Lost to Reds (45-39), 6-5 | Crosley Field (1-1) | 39-47 | Lost 2 |
| » Starters: Larry Yellen vs John Tsitouris | Ninth | 13½ out |
| » Lost to Reds (46-39), 10-3 | Crosley Field (1-2) | 39-48 | Lost 3 |
| » Starters: Ken Johnson vs Jim Maloney | Ninth | 13½ out |
| Wednesday, July 15 |
| » Lost to Reds (47-39), 2-1 | Crosley Field (1-3) | 39-49 | Lost 4 |
| » Starters: Turk Farrell vs Jim O'Toole | Eighth | 13½ out |
| Thursday, July 16 |
| » Lost to Reds (48-39), 3-2 | Crosley Field (1-4) | 39-50 | Lost 5 |
| » Starters: Don Nottebart vs Joe Nuxhall | Ninth | 13½ out |
| Friday, July 17 |
| » Defeated Giants (52-37), 5-2 | Candlestick Park (1-2) | 40-50 | |
| » Starters: Bob Bruce vs Ron Herbel | Ninth | 13½ out |
| Saturday, July 18 |
| » Defeated Giants (52-38), 2-1 | Candlestick Park (2-2) | 41-50 | Won 2 |
| » Starters: Ken Johnson vs Billy O'Dell | Eighth | 12½ out |
| Sunday, July 19 |
| » Lost to Giants (53-38), 4-2 | Candlestick Park (2-3) | 41-51 | |
| » Starters: Turk Farrell vs Juan Marichal | Ninth | 13½ out |
| » Lost to Giants (54-38), 1-0 | Candlestick Park (2-4) | 41-52 | Lost 2 |
| » Starters: Hal Brown vs Bob Hendley | Ninth | 13½ out |
| Monday, July 20 |
| » Defeated Dodgers (45-46), 4-1 | Dodger Stadium (2-1) | 42-52 | |
| » Starters: Jim Owens vs Joe Moeller | Ninth | 12½ out |
| Tuesday, July 21 |
| » Defeated Dodgers (45-47), 1-0 | Dodger Stadium (3-1) | 43-52 | Won 2 |
| » Starters: Bob Bruce vs Don Drysdale | Ninth | 12½ out |
| Wednesday, July 22 |
| » Lost to Dodgers (46-47), 1-0 | Dodger Stadium (3-2) | 43-53 | |
| » Starters: Ken Johnson vs Sandy Koufax | Ninth | 13½ out |
| Thursday, July 23 |
| » Lost to Dodgers (47-47), 5-4 | Dodger Stadium (3-3) | 43-54 | Lost 2 |
| » Starters: Turk Farrell vs Phil Ortega | Seventh | 14½ out |
| Friday, July 24 |
| » Defeated Cubs (47-47), 1-0 | Colt Stadium (25-28) | 44-54 | |
| » Starters: Dick Ellsworth vs Hal Brown | Eighth | 14½ out |
| Saturday, July 25 |
| » Defeated Cubs (47-48), 5-3 | Colt Stadium (26-28) | 45-54 | Won 2 |
| » Starters: Bob Buhl vs Bob Bruce | Eighth | 13½ out |
| Sunday, July 26 |
| » Lost to Cubs (48-48), 3-0 | Colt Stadium (26-29) | 45-55 | |
| » Starters: Larry Jackson vs Ken Johnson | Ninth | 13 out |
| Monday, July 27 |
| » Major-league debuts: Dave Eilers (Braves) |
| Wednesday, July 29 |
| » Lost to Pirates (51-44), 5-2 | Forbes Field (1-3) | 45-56 | Lost 2 |
| » Starters: Turk Farrell vs Bob Friend | Eighth | 13½ out |
| Thursday, July 30 |
| » Lost to Pirates (52-44), 1-0 | Forbes Field (1-4) | 45-57 | Lost 3 |
| » Starters: Bob Bruce vs Vern Law | Ninth | 15 out |
| » Lost to Pirates (53-44), 8-3 | Forbes Field (1-5) | 45-58 | Lost 4 |
| » Starters: Jim Owens vs Don Schwall | Ninth | 15 out |
| Friday, July 31 |
| » Lost to Mets (31-72), 3-0 | Shea Stadium (1-2) | 45-59 | Lost 5 |
| » Starters: Don Larsen vs Frank Lary | Ninth | 16½ out |
| » Lost to Mets (32-72), 6-2 | Shea Stadium (1-3) | 45-60 | Lost 6 |
| » Starters: Ken Johnson vs Jack Fisher | Ninth | 16½ out |
| Saturday, August 1 |
| » Lost to Mets (33-72), 3-2 | Shea Stadium (1-4) | 45-61 | Lost 7 |
| » Starters: Hal Brown vs Al Jackson | Ninth | 17½ out |
| Sunday, August 2 |
| » Defeated Mets (33-73), 9-7 | Shea Stadium (2-4) | 46-61 | |
| » Starters: Turk Farrell vs Darrell Sutherland | Ninth | 17 out |
| » Lost to Mets (34-73), 4-2 | Shea Stadium (2-5) | 46-62 | |
| » Starters: Jim Owens vs Ron Locke | Ninth | 17 out |
| Wednesday, August 5 |
| » Lost to Phillies (61-42), 4-1 | Shibe Park (0-4) | 46-63 | Lost 2 |
| » Starters: Bob Bruce vs Jim Bunning | Eighth | 19 out |
| » Lost to Phillies (62-42), 2-1 | Shibe Park (0-5) | 46-64 | Lost 3 |
| » Starters: Ken Johnson vs Ray Culp | Eighth | 19 out |
| Thursday, August 6 |
| » Defeated Phillies (62-43), 2-1 | Shibe Park (1-5) | 47-64 | |
| » Starters: Turk Farrell vs Chris Short | Ninth | 18 out |
| Friday, August 7 |
| » Lost to Cardinals (57-51), 4-0 | Sportsman's Park III (3-4) | 47-65 | |
| » Starters: Hal Brown vs Curt Simmons | Ninth | 19 out |
| Saturday, August 8 |
| » Defeated Cardinals (57-52), 4-3 | Sportsman's Park III (4-4) | 48-65 | |
| » Starters: Don Nottebart vs Ron Taylor | Ninth | 19 out |
| Sunday, August 9 |
| » Lost to Cardinals (58-52), 8-2 | Sportsman's Park III (4-5) | 48-66 | |
| » Starters: Bob Bruce vs Ray Sadecki | Ninth | 20 out |
| Monday, August 10 |
| Future Astro Andy Stankiewicz is born in Inglewood, CA. |
| Tuesday, August 11 |
| » Lost to Braves (57-54), 9-6 | County Stadium (6-2) | 48-67 | Lost 2 |
| » Starters: Ken Johnson vs Warren Spahn | Ninth | 21 out |
| Wednesday, August 12 |
| » Lost to Braves (58-54), 5-1 | County Stadium (6-3) | 48-68 | Lost 3 |
| » Starters: Hal Brown vs Tony Cloninger | Ninth | 22 out |
| Thursday, August 13 |
| Future Astro Gary Cooper is born in Lynwood, CA. |
| Friday, August 14 |
| » Defeated Reds (63-53), 3-2 | Colt Stadium (27-29) | 49-68 | |
| » Starters: Jim Maloney vs Bob Bruce | Ninth | 22 out |
| Saturday, August 15 |
| » Defeated Reds (63-54), 7-4 | Colt Stadium (28-29) | 50-68 | Won 2 |
| » Starters: Joe Nuxhall vs Don Nottebart | Ninth | 22 out |
| Sunday, August 16 |
| » Lost to Reds (64-54), 8-3 | Colt Stadium (28-30) | 50-69 | |
| » Starters: Joey Jay vs Ken Johnson | Ninth | 22 out |
| Monday, August 17 |
| » Lost to Cardinals (63-55), 3-1 | Colt Stadium (28-31) | 50-70 | Lost 2 |
| » Starters: Roger Craig vs Hal Brown | Ninth | 23 out |
| Tuesday, August 18 |
| » Lost to Cardinals (64-55), 5-2 | Colt Stadium (28-32) | 50-71 | Lost 3 |
| » Starters: Ray Sadecki vs Don Larsen | Ninth | 23 out |
| Wednesday, August 19 |
| » Defeated Cardinals (64-56), 8-7 | Colt Stadium (29-32) | 51-71 | |
| » Starters: Bob Gibson vs Don Nottebart | Ninth | 23 out |
| Friday, August 21 |
| » Defeated Braves (62-58), 3-2 | Colt Stadium (30-32) | 52-71 | Won 2 |
| » Starters: Tony Cloninger vs Ken Johnson | Ninth | 24 out |
| Saturday, August 22 |
| » Defeated Braves (62-59), 5-4 | Colt Stadium (31-32) | 53-71 | Won 3 |
| » Starters: Denny Lemaster vs Hal Brown | Ninth | 23 out |
| Sunday, August 23 |
| » Defeated Braves (62-60), 7-1 | Colt Stadium (32-32) | 54-71 | Won 4 |
| » Starters: Warren Spahn vs Don Larsen | Eighth | 23 out |
| Monday, August 24 |
| » Defeated Cubs (57-68), 2-0 | Colt Stadium (33-32) | 55-71 | Won 5 |
| » Starters: Lew Burdette vs Bob Bruce | Ninth | 22 out |
| Future Astro Kip Gross is born in Scottsbluff, NE. |
| Tuesday, August 25 |
| » Defeated Cubs (57-69), 5-4 | Colt Stadium (34-32) | 56-71 | Won 6 |
| » Starters: John Flavin vs Ken Johnson | Ninth | 21 out |
| Wednesday, August 26 |
| » Lost to Cubs (58-69), 3-1 | Colt Stadium (34-33) | 56-72 | |
| » Starters: Larry Jackson vs Hal Brown | Ninth | 22 out |
| Saturday, August 29 |
| » Lost to Reds (71-56), 2-1 | Crosley Field (1-5) | 56-73 | Lost 2 |
| » Starters: Don Larsen vs John Tsitouris | Ninth | 23 out |
| » Lost to Reds (72-56), 8-7 | Crosley Field (1-6) | 56-74 | Lost 3 |
| » Starters: Don Nottebart vs Jim O'Toole | Ninth | 23 out |
| Sunday, August 30 |
| » Defeated Reds (72-57), 8-5 | Crosley Field (2-6) | 57-74 | |
| » Starters: Bob Bruce vs Bob Purkey | Eighth | 22½ out |
| » Lost to Reds (73-57), 7-6 | Crosley Field (2-7) | 57-75 | |
| » Starters: Ken Johnson vs Joey Jay | Eighth | 22½ out |
| Tuesday, September 1 |
| » Lost to Phillies (79-51), 4-3 | Shibe Park (1-6) | 57-76 | Lost 2 |
| » Starters: Hal Brown vs Jim Bunning | Ninth | 23½ out |
| Wednesday, September 2 |
| » Lost to Phillies (80-51), 2-1 | Shibe Park (1-7) | 57-77 | Lost 3 |
| » Starters: Don Nottebart vs Chris Short | Ninth | 24½ out |
| » Major-league debuts: Adolfo Phillips (Phillies) |
| Thursday, September 3 |
| » Defeated Phillies (80-52), 6-0 | Shibe Park (2-7) | 58-77 | |
| » Starters: Don Larsen vs Dennis Bennett | Ninth | 23½ out |
| Friday, September 4 |
| » Lost to Pirates (68-65), 10-2 | Forbes Field (1-6) | 58-78 | |
| » Starters: Bob Bruce vs Bob Veale | Ninth | 24½ out |
| Saturday, September 5 |
| » Lost to Pirates (69-65), 4-1 | Forbes Field (1-7) | 58-79 | Lost 2 |
| » Starters: Ken Johnson vs Bob Friend | Ninth | 25½ out |
| Sunday, September 6 |
| » Lost to Pirates (70-65), 1-0 | Forbes Field (1-8) | 58-80 | Lost 3 |
| » Starters: Don Nottebart vs Vern Law | Ninth | 25½ out |
| Monday, September 7 |
| » Lost to Mets (47-91), 7-5 | Shea Stadium (2-6) | 58-81 | Lost 4 |
| » Starters: Hal Brown vs Al Jackson | Eighth | 26½ out |
| » Lost to Mets (48-91), 6-4 | Shea Stadium (2-7) | 58-82 | Lost 5 |
| » Starters: Don Larsen vs Jack Fisher | Eighth | 26½ out |
| Wednesday, September 9 |
| » Lost to Cubs (63-76), 6-3 | Wrigley Field (2-6) | 58-83 | Lost 6 |
| » Starters: Bob Bruce vs Dick Ellsworth | Ninth | 26 out |
| Thursday, September 10 |
| » Lost to Cubs (64-76), 4-3 | Wrigley Field (2-7) | 58-84 | Lost 7 |
| » Starters: Ken Johnson vs Larry Jackson | Eighth | 27 out |
| Friday, September 11 |
| » Lost to Pirates (72-68), 3-0 | Colt Stadium (34-34) | 58-85 | Lost 8 |
| » Starters: Vern Law vs Don Nottebart | Ninth | 28 out |
| Saturday, September 12 |
| » Defeated Pirates (72-69), 2-1 | Colt Stadium (35-34) | 59-85 | |
| » Starters: Tom Butters vs Don Larsen | Ninth | 27 out |
| Sunday, September 13 |
| » Lost to Pirates (73-69), 3-0 | Colt Stadium (35-35) | 59-86 | |
| » Starters: Don Cardwell vs Turk Farrell | Ninth | 28 out |
| Monday, September 14 |
| » Lost to Phillies (87-57), 4-1 | Colt Stadium (35-36) | 59-87 | Lost 2 |
| » Starters: Chris Short vs Bob Bruce | Eighth | 29 out |
| Tuesday, September 15 |
| » Lost to Phillies (88-57), 1-0 | Colt Stadium (35-37) | 59-88 | Lost 3 |
| » Starters: Dennis Bennett vs Ken Johnson | Ninth | 30 out |
| Wednesday, September 16 |
| » Defeated Phillies (88-58), 6-5 | Colt Stadium (36-37) | 60-88 | |
| » Starters: Jim Bunning vs Don Nottebart | Ninth | 29 out |
| Friday, September 18 |
| » Defeated Mets (50-97), 3-2 | Colt Stadium (37-37) | 61-88 | Won 2 |
| » Starters: Al Jackson vs Don Larsen | Ninth | 28½ out |
| Saturday, September 19 |
| » Defeated Mets (50-98), 2-1 | Colt Stadium (38-37) | 62-88 | Won 3 |
| » Manager: Lum Harris |
| » Starters: Jack Fisher vs Turk Farrell | Ninth | 27½ out |
| Sunday, September 20 |
| » Defeated Mets (50-99), 1-0 | Colt Stadium (39-37) | 63-88 | Won 4 |
| » Starters: Tom Parsons vs Bob Bruce | Eighth | 27½ out |
| Monday, September 21 |
| » Defeated Giants (83-68), 3-1 | Colt Stadium (40-37) | 64-88 | Won 5 |
| » Starters: Bobby Bolin vs Ken Johnson | Ninth | 26½ out |
| Tuesday, September 22 |
| » Lost to Giants (84-68), 7-1 | Colt Stadium (40-38) | 64-89 | |
| » Starters: Dick Estelle vs Larry Dierker | Ninth | 26½ out |
| » Major-league debuts: Larry Dierker (Astros) |
| Wednesday, September 23 |
| » Lost to Giants (85-68), 4-1 | Colt Stadium (40-39) | 64-90 | Lost 2 |
| » Starters: Juan Marichal vs Don Larsen | Ninth | 26½ out |
| Friday, September 25 |
| » Lost to Dodgers (76-78), 7-2 | Colt Stadium (40-40) | 64-91 | Lost 3 |
| » Starters: Jim Brewer vs Turk Farrell | Ninth | 26 out |
| Sunday, September 27 |
| » Defeated Dodgers (76-79), 1-0 | Colt Stadium (41-40) | 65-91 | |
| » Starters: Don Drysdale vs Bob Bruce | Ninth | 25½ out |
| Tuesday, September 29 |
| » Lost to Giants (87-70), 5-4 | Candlestick Park (2-5) | 65-92 | |
| » Starters: Ken Johnson vs Dick Estelle | Eighth | 25½ out |
| Wednesday, September 30 |
| » Lost to Giants (88-70), 2-1 | Candlestick Park (2-6) | 65-93 | Lost 2 |
| » Starters: Turk Farrell vs Gaylord Perry | Ninth | 26½ out |
| Thursday, October 1 |
| » Lost to Giants (89-70), 6-3 | Candlestick Park (2-7) | 65-94 | Lost 3 |
| » Starters: Chris Zachary vs Juan Marichal | Ninth | 27 out |
| Friday, October 2 |
| » Defeated Dodgers (78-82), 6-1 | Dodger Stadium (4-3) | 66-94 | |
| » Starters: Danny Coombs vs |
